CN109419996A - A kind of Chinese medicine that treating bacterial vaginitis and preparation method - Google Patents
A kind of Chinese medicine that treating bacterial vaginitis and preparation method Download PDFInfo
- Publication number
- CN109419996A CN109419996A CN201710746210.9A CN201710746210A CN109419996A CN 109419996 A CN109419996 A CN 109419996A CN 201710746210 A CN201710746210 A CN 201710746210A CN 109419996 A CN109419996 A CN 109419996A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- root
- powder
- mixed powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 title claims abstract description 52
- 208000004926 Bacterial Vaginosis Diseases 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 244000025254 Cannabis sativa Species 0.000 claims abstract description 39
- 241000195974 Selaginella Species 0.000 claims abstract description 31
- 239000000463 material Substances 0.000 claims abstract description 25
- 244000130592 Hibiscus syriacus Species 0.000 claims abstract description 18
- 235000018081 Hibiscus syriacus Nutrition 0.000 claims abstract description 18
- 240000000178 Monochoria vaginalis Species 0.000 claims abstract description 18
- 241000208720 Nepenthes Species 0.000 claims abstract description 18
- 241000096270 Swertia leducii Species 0.000 claims abstract description 18
- 241001075517 Abelmoschus Species 0.000 claims abstract description 17
- 241000432824 Asparagus densiflorus Species 0.000 claims abstract description 17
- 241000287828 Gallus gallus Species 0.000 claims abstract description 17
- 241000421432 Glochidion Species 0.000 claims abstract description 17
- 241000906682 Hemsleya Species 0.000 claims abstract description 17
- 241000718543 Ormosia krugii Species 0.000 claims abstract description 17
- 235000018907 Tylosema fassoglense Nutrition 0.000 claims abstract description 17
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 17
- 241000317854 Uncinata Species 0.000 claims abstract description 14
- 244000016281 Cymbalaria muralis Species 0.000 claims abstract description 13
- 235000015916 Hydrocotyle vulgaris Nutrition 0.000 claims abstract description 13
- 241000330755 Tylosema fassoglense Species 0.000 claims abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 44
- 239000011812 mixed powder Substances 0.000 claims description 38
- 239000000843 powder Substances 0.000 claims description 28
- 239000002245 particle Substances 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 238000010438 heat treatment Methods 0.000 claims description 21
- 235000019441 ethanol Nutrition 0.000 claims description 19
- 239000000706 filtrate Substances 0.000 claims description 15
- 239000011159 matrix material Substances 0.000 claims description 15
- 241000196324 Embryophyta Species 0.000 claims description 13
- 239000000829 suppository Substances 0.000 claims description 13
- 238000001816 cooling Methods 0.000 claims description 11
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 10
- 229960000502 poloxamer Drugs 0.000 claims description 10
- 229920001983 poloxamer Polymers 0.000 claims description 10
- 239000002105 nanoparticle Substances 0.000 claims description 9
- 239000002552 dosage form Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 229920000742 Cotton Polymers 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 125000005456 glyceride group Chemical group 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 239000006210 lotion Substances 0.000 claims description 5
- 238000002844 melting Methods 0.000 claims description 5
- 230000008018 melting Effects 0.000 claims description 5
- 238000000643 oven drying Methods 0.000 claims description 5
- 239000004033 plastic Substances 0.000 claims description 5
- 229920003023 plastic Polymers 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 238000007493 shaping process Methods 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- 239000004166 Lanolin Substances 0.000 claims description 4
- 229940039717 lanolin Drugs 0.000 claims description 4
- 235000019388 lanolin Nutrition 0.000 claims description 4
- 238000005325 percolation Methods 0.000 claims description 4
- NNBFNNNWANBMTI-UHFFFAOYSA-M brilliant green Chemical compound OS([O-])(=O)=O.C1=CC(N(CC)CC)=CC=C1C(C=1C=CC=CC=1)=C1C=CC(=[N+](CC)CC)C=C1 NNBFNNNWANBMTI-UHFFFAOYSA-M 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 244000301850 Cupressus sempervirens Species 0.000 claims 2
- 238000007792 addition Methods 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 13
- 231100000331 toxic Toxicity 0.000 abstract description 6
- 230000002588 toxic effect Effects 0.000 abstract description 6
- 239000000796 flavoring agent Substances 0.000 description 20
- 235000019634 flavors Nutrition 0.000 description 20
- 241000220487 Bauhinia Species 0.000 description 13
- 239000008280 blood Substances 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 13
- 210000004072 lung Anatomy 0.000 description 13
- 208000004880 Polyuria Diseases 0.000 description 11
- 230000035619 diuresis Effects 0.000 description 11
- 208000001848 dysentery Diseases 0.000 description 10
- 230000010415 tropism Effects 0.000 description 10
- 206010011224 Cough Diseases 0.000 description 9
- 210000004185 liver Anatomy 0.000 description 9
- 230000001737 promoting effect Effects 0.000 description 9
- 206010007247 Carbuncle Diseases 0.000 description 7
- 208000000616 Hemoptysis Diseases 0.000 description 7
- 206010023126 Jaundice Diseases 0.000 description 7
- 235000009508 confectionery Nutrition 0.000 description 7
- 210000001215 vagina Anatomy 0.000 description 7
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 206010000269 abscess Diseases 0.000 description 5
- 231100000614 poison Toxicity 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 231100000419 toxicity Toxicity 0.000 description 5
- 230000001988 toxicity Effects 0.000 description 5
- 241000218208 Caltha Species 0.000 description 4
- 235000008749 Caltha palustris Nutrition 0.000 description 4
- 201000004624 Dermatitis Diseases 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 208000003251 Pruritus Diseases 0.000 description 4
- 208000004078 Snake Bites Diseases 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 4
- 208000010668 atopic eczema Diseases 0.000 description 4
- 208000014617 hemorrhoid Diseases 0.000 description 4
- 206010022000 influenza Diseases 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 210000002429 large intestine Anatomy 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 241000219071 Malvaceae Species 0.000 description 3
- 206010053615 Thermal burn Diseases 0.000 description 3
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 210000000232 gallbladder Anatomy 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 208000035861 hematochezia Diseases 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 230000027939 micturition Effects 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 206010010741 Conjunctivitis Diseases 0.000 description 2
- 208000034656 Contusions Diseases 0.000 description 2
- 208000004232 Enteritis Diseases 0.000 description 2
- 208000007882 Gastritis Diseases 0.000 description 2
- 206010018612 Gonorrhoea Diseases 0.000 description 2
- 201000005702 Pertussis Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 206010044565 Tremor Diseases 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 208000034526 bruise Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000002242 deionisation method Methods 0.000 description 2
- 230000035617 depilation Effects 0.000 description 2
- 230000002951 depilatory effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 208000001786 gonorrhea Diseases 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 208000021760 high fever Diseases 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 201000005630 leukorrhea Diseases 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 2
- 208000019206 urinary tract infection Diseases 0.000 description 2
- 206010046901 vaginal discharge Diseases 0.000 description 2
- 231100000611 venom Toxicity 0.000 description 2
- 210000003905 vulva Anatomy 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 244000144619 Abrus precatorius Species 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 241000208173 Apiaceae Species 0.000 description 1
- 206010003399 Arthropod bite Diseases 0.000 description 1
- 241000432767 Asparagus setaceus Species 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000003910 Baronia <angiosperm> Species 0.000 description 1
- 235000009759 Bauhinia variegata Nutrition 0.000 description 1
- 206010006002 Bone pain Diseases 0.000 description 1
- 241000208828 Caprifoliaceae Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 206010012434 Dermatitis allergic Diseases 0.000 description 1
- 235000007901 Diospyros malabarica Nutrition 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 244000063515 Erythrina indica Species 0.000 description 1
- 241000221079 Euphorbia <genus> Species 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 241001071804 Gentianaceae Species 0.000 description 1
- 241000785778 Glochidion puberum Species 0.000 description 1
- 206010019345 Heat stroke Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 241000229537 Moxostoma Species 0.000 description 1
- 208000001907 Mushroom Poisoning Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 241000208719 Nepenthaceae Species 0.000 description 1
- 241000123069 Ocyurus chrysurus Species 0.000 description 1
- 206010034038 Parotitis Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 241000757039 Pontederiaceae Species 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 241000593989 Scardinius erythrophthalmus Species 0.000 description 1
- 241000967218 Selaginella tamariscina Species 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 241001530209 Swertia Species 0.000 description 1
- 235000004869 Tussilago farfara Nutrition 0.000 description 1
- 208000037009 Vaginitis bacterial Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 201000004484 acute conjunctivitis Diseases 0.000 description 1
- 201000004427 acute laryngopharyngitis Diseases 0.000 description 1
- 206010001093 acute tonsillitis Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000028659 discharge Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethanethiol Chemical compound CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000003118 histopathologic effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 201000007094 prostatitis Diseases 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of Chinese medicine for treating bacterial vaginitis and preparation method, each raw medicinal material of Chinese medicine includes: moellendorf spikemoss herb, common nepenthes, Herba Malvastri Coromandeliani, puberulous glochidion branchlet and leaf, swertia mileensis, setose abelmoschus root, Canton love-pea vine, Uncinata Spikemoss Herb, hupeh bauhinia root, nepal pennywort herb, mountain Radix Glycyrrhizae, shrub althea flower, fourth last of the ten Heavenly stems grass, Monochoria vaginalis, henry hemsleya root, Toxin-Vanquishing grass, chicken bone bavin and asparagus fern.Chinese medicine of the present invention has definite curative effect to bacterial vaginitis, and toxic side effect is small, uneasy to recur.
Description
Technical field
The present invention relates to containing from plant, the medicinal preparation of animal or mineral component more particularly to a kind for the treatment of
The Chinese medicine and preparation method of bacterial vaginitis.
Background technique
Bacterial vaginitis (BV) is common one of gynaecological imflammation, is mixed bacterial infection, is mainly shown as vagina
Secretion increases, stench.Can there are slight pruritus vulvue or burn feeling, it is easy to recur, there is infectiousness, 10-40% patient is without clinic
Symptom seriously affects patients ' life quality.
The feature of BV is the change of vaginal environment, i.e., advantage Bacillus acidi lactici is replaced a large amount of pathogenic anaerobic bacterias, therefore faces
Bed is mostly to treat anaerobic bacteria effective first nitre file.Most effective treatment is preferred oral first nitre file, but due to oral
First nitre file gastrointestinal reaction is big, and patient should not receive or cannot adhere to treating, and tend to vagina local application in recent years, it is believed that medicine
Object directly applies to pathogen, equally there is preferable effect, can also reduce side reaction, but still still has certain side effect.
Bacterial vaginitis belongs to traditional Chinese medicine " leukorrhagia " scope.Mainly dampness-heat of liver channel or stagnation of liver-QI with deficiency of the spleen, damp invasion of lower energizer are strongly fragrant
It ties caused by external genitals.Principle of reatment is removing damp-heat, removing pattogenic heat from the blood and toxic material from the body, sterilizing and itch-relieving.
Summary of the invention
Technical problem to be solved by the present invention lies in provide a kind of Chinese medicine for treating bacterial vaginitis and preparation side
Method, Chinese medicine of the present invention have definite curative effect to bacterial vaginitis, and toxic side effect is small, uneasy to recur.
In order to solve the above-mentioned technical problems, the present invention provides a kind of Chinese medicine for treating bacterial vaginitis, bulk pharmaceutical chemicals
Material includes: moellendorf spikemoss herb, common nepenthes, Herba Malvastri Coromandeliani, puberulous glochidion branchlet and leaf, swertia mileensis, setose abelmoschus root, Canton love-pea vine, Uncinata Spikemoss Herb, hupeh bauhinia root, red horse
Hoof grass, mountain Radix Glycyrrhizae, shrub althea flower, fourth last of the ten Heavenly stems grass, Monochoria vaginalis, henry hemsleya root, Toxin-Vanquishing grass, chicken bone bavin and asparagus fern.
The weight fraction ratio of each raw medicinal material is as follows in the Chinese medicine: 20~30 parts of moellendorf spikemoss herb, 15~25 parts of common nepenthes, and match
15~25 parts of certain herbaceous plants with big flowers, 5~15 parts of puberulous glochidion branchlet and leaf, 10~20 parts of swertia mileensis, 35~45 parts of setose abelmoschus root, 5~15 parts of Canton love-pea vine, emerald green cloud
35~45 parts of grass, 20~30 parts of hupeh bauhinia root, 10~20 parts of nepal pennywort herb, 10~20 parts of mountain Radix Glycyrrhizae, 20~30 parts of shrub althea flower, the fourth last of the ten Heavenly stems
15~25 parts of grass, 15~25 parts of Monochoria vaginalis, 5~15 parts of henry hemsleya root, 10~20 parts of Toxin-Vanquishing grass, 5~15 parts of chicken bone bavin and asparagus fern 10
~20 parts.
The weight fraction ratio of each raw medicinal material can be preferred in the Chinese medicine are as follows: and 20~25 parts of moellendorf spikemoss herb, common nepenthes 15~
20 parts, 15~20 parts of Herba Malvastri Coromandeliani, 5~10 parts of puberulous glochidion branchlet and leaf, 10~15 parts of swertia mileensis, 35~40 parts of setose abelmoschus root, Canton love-pea vine 5~10
Part, 35~40 parts of Uncinata Spikemoss Herb, 20~25 parts of hupeh bauhinia root, 10~15 parts of nepal pennywort herb, 10~15 parts of mountain Radix Glycyrrhizae, shrub althea flower 20~25
Part, 15~20 parts of fourth last of the ten Heavenly stems grass, 15~20 parts of Monochoria vaginalis, 5~10 parts of henry hemsleya root, 10~15 parts of Toxin-Vanquishing grass, 5~10 parts of chicken bone bavin and
10~15 parts of asparagus fern.
The weight fraction ratio of each raw medicinal material can also be preferred in the Chinese medicine are as follows: and 23 parts of moellendorf spikemoss herb, 18 parts of common nepenthes, match
It is 16 parts of certain herbaceous plants with big flowers, 8 parts of puberulous glochidion branchlet and leaf, 12 parts of swertia mileensis, 37 parts of setose abelmoschus root, 6 parts of Canton love-pea vine, 39 parts of Uncinata Spikemoss Herb, 24 parts of hupeh bauhinia root, red
13 parts of membranaceous marshmarigold herb, 14 parts of mountain Radix Glycyrrhizae, 23 parts of shrub althea flower, 19 parts of fourth last of the ten Heavenly stems grass, 16 parts of Monochoria vaginalis, 7 parts of henry hemsleya root, 12 parts of Toxin-Vanquishing grass,
6 parts and 14 parts of asparagus fern of chicken bone bavin.
The weight fraction ratio of each raw medicinal material can also be preferred in the Chinese medicine are as follows: and 25 parts of moellendorf spikemoss herb, 16 parts of common nepenthes, match
It is 19 parts of certain herbaceous plants with big flowers, 6 parts of puberulous glochidion branchlet and leaf, 14 parts of swertia mileensis, 40 parts of setose abelmoschus root, 8 parts of Canton love-pea vine, 36 parts of Uncinata Spikemoss Herb, 22 parts of hupeh bauhinia root, red
11 parts of membranaceous marshmarigold herb, 12 parts of mountain Radix Glycyrrhizae, 24 parts of shrub althea flower, 17 parts of fourth last of the ten Heavenly stems grass, 18 parts of Monochoria vaginalis, 8 parts of henry hemsleya root, 15 parts of Toxin-Vanquishing grass,
8 parts and 13 parts of asparagus fern of chicken bone bavin.
The present invention also provides the preparation method of above-mentioned Chinese medicine, the dosage form of the Chinese medicine is suppository, and preparation method includes
Following steps:
Step 1: the raw material is soaked in water 30 minutes to 1 hour, heating is boiled 50~60 minutes, is filtered, and filtrate is standby
With；Filter residue, which adds second of water, to be heated, and is boiled 30~40 minutes, is filtered, filtrate is spare；Filter residue adds water, and third time heating is boiled
20~30 minutes, filtering；It filtrate will be combined three times, heating is concentrated into paste, is put into cooling, grinding after 70 DEG C of baking oven drying
At fine powder.
Step 2: taking a kind of in semi-synthetic fatty glyceride, lanolin, polyethylene glycol and poloxamer poloxamer
Or it is a variety of as matrix；By the matrix under the conditions of temperature 60 C~70 DEG C heating and melting, be added the first step obtained by fine powder, water
Bath stirs evenly, and is mixed into sticky liquid, is poured in plastic shape-forming pipe, is inserted into tampon, and bullet-shaped is made in cooling and shaping
Suppository；The proportion of the fine powder and matrix is 1: 3~1: 5；The tampon is the tampon that tail portion has cotton thread.
The present invention also provides the preparation method of above-mentioned Chinese medicine, the dosage form of the Chinese medicine is washing lotion, and preparation method includes
Following steps:
Step 1: the raw medicinal material is mixed in proportion, it is put into micronizer that be ground into 0.1~10 μm of volume flat
The micron particles and partial size of equal partial size are described less than the mixed powder that the nano-scale particle of 0.1 μm of volume average particle size forms
The powder rate that obtains of mixed powder is at least 97%；
Step 2: 3~5 times of quality of the alcohol relative to the mixed powder is added in the mixed powder that the first step obtains
The ethyl alcohol that concentration is 70%~80%, stirring and dissolving obtain ethanol solution, ethanol solution are stood under conditions of 5 DEG C~10 DEG C
24~36 hours, using percolation with the speed of 1~2ml per minute, slowly diacolation, collection percolate were concentrated and dried, and
This is put into micronizer and crushes 30~60 minutes, obtains the micron particles and partial size of 0.1~10 μm of volume average particle size
Less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of the mixed powder is at least
97%；
Step 3: the deionization relative to 5~7 times of mixed powder quality is added in the mixed powder that second step obtains
Water decocts 1~3 hour, and filtering obtains decoction.
Beneficial effects of the present invention: Chinese medicine of the present invention has definite curative effect to bacterial vaginitis, and toxic side effect is small, is not easy multiple
Hair.
Specific embodiment
The present invention provides a kind of Chinese medicine for treating bacterial vaginitis, raw medicinal material includes: moellendorf spikemoss herb, common nepenthes,
Herba Malvastri Coromandeliani, puberulous glochidion branchlet and leaf, swertia mileensis, setose abelmoschus root, Canton love-pea vine, Uncinata Spikemoss Herb, hupeh bauhinia root, nepal pennywort herb, mountain Radix Glycyrrhizae, shrub althea flower, fourth
Last of the ten Heavenly stems grass, Monochoria vaginalis, henry hemsleya root, Toxin-Vanquishing grass, chicken bone bavin and asparagus fern.
The pharmacology of each raw medicinal material is as follows in the Chinese medicine:
Moellendorf spikemoss herb: [source] is the herb of Spikemoss plant selaginella tamariscina.[nature and flavor] are sweet, pungent, put down.[channel tropism] returns liver, gallbladder,
Lung channel.[major function] clearing heat and promoting diuresis, hemostasis.Main lung heat hemoptysis, spits blood, bleeding from five sense organs or subcutaneous tissue, hematochezia, hemorrhoid hemorrhage, traumatic hemorrhage, hair
Heat, child convulsion, jaundice with damp-heat pathogen, stranguria syndrome, oedema, scald.
Common nepenthes: [source] is the cauline leaf of Nepenthaceae plant common nepenthes.[nature and flavor] are sweet, light, cool.[channel tropism] return lung, gallbladder,
Stomach meridian.[major function] moistening lung to arrest cough, clearing heat and promoting diuresis arrange stone, removing toxicity for detumescence.Main dryness of the lung hemoptysis, cold cough, pertussis are yellow
Subcutaneous ulcer, dysentery, lithangiuria also can be used for gastric and duodenal ulcer, high blood pressure, diabetes, sore carbuncle swells.
Herba Malvastri Coromandeliani: [source] is the herb of malvaceae plant Herba Malvastri Coromandeliani.[nature and flavor] micro-sweet, it is cool.[channel tropism] return lung, liver, large intestine channel.
[major function] clearing heat and promoting diuresis, removing toxicity for detumescence.Main damp-heat dysentery, jaundice, cough with lung heat, abscess of throat, hemorrhoid, carbuncle sore tumefacting virus,
Traumatic injury, prostatitis.
Puberulous glochidion branchlet and leaf: [source] is the leaf of euphorbia plant Glochidion puberum.[nature and flavor] bitter, it is puckery, it is cool in nature.[channel tropism] returns large intestine
Through.[major function] clearing heat and promoting diuresis, removing toxicity for detumescence.Main damp-heat dysentery, jaundice, stranguria with turbid discharge, leukorrhagia, fever, abscess of throat, ulcerative carbuncle furuncle
It is swollen, dermatitis rhus, eczema, snakebite and bugbite.
Swertia mileensis: [source] is the herb of gentianaceae plant swertia mileensis, yunnan swertia herb and Herba Swertiae bimaculatae.[nature and flavor] are bitter,
It is cold in nature.[channel tropism] returns liver, gallbladder, bladder meridian.[major function] is clearing heat and detoxicating, removing dampness through diuresis and removing jaundice.Main jaundice with damp-heat pathogen, puckery pain of heat gonorrhea are wet
Hot dysentery, leukorrhea with reddish discharge, influenza, malaria fever, acute gastritis, acute laryngopharyngitis, acute tonsillitis.External application can be controlled
Acute conjunctivitis, allergic dermatitis.
Setose abelmoschus root: [source] is the root of malvaceae plant bristle okra.[nature and flavor] are bitter, tremble with fear.[major function] heat-clearing
Dampness removing.It harnesses the river swollen, urinary tract infections.
Canton love-pea vine: [source] is the herb of leguminous plant Guangdong jequirity.[nature and flavor] are sweet, bitter, cool.[channel tropism] return heart, lung,
Liver, stomach, kidney channel.[major function] clearing heat and promoting diuresis, removing blood stasis and acesodyne.Main icteric hepatitis, stomachache, treating rheumatic ostealgia, bruise stasis caused pain, cream
Carbuncle.
Uncinata Spikemoss Herb: [source] is the herb of Spikemoss plant Uncinata Spikemoss Herb.[nature and flavor] are light, and slight bitter is cool.[major function] heat-clearing
Dampness removing detoxifies, hemostasis.Main jaundice, dysentery, diarrhea, oedema, stranguria syndrome, myalgia are spitted blood, hemoptysis, hematochezia, traumatic hemorrhage, hemorrhoid
Fistula, burn and scald, snake bite.
Hupeh bauhinia root: [source] is the root or cauline leaf of leguminous plant Hubei Province mountain ebony.[nature and flavor] are bitter, puckery, put down.[channel tropism] returns kidney,
Large intestine channel.[major function] astringency inducing, removing toxic substances dehumidifying.Main cough hemoptysis, spits blood, hematochezia, the enuresis, frequent micturition, leukorrhea, and uterus is de-
It hangs down, dysentery, numbness pain, hernia, testiclar gall, eczema, boil swelling and pain.
Nepal pennywort herb: [source] is the herb of umbelliferae nepal pennywort herb.[nature and flavor] bitter, it is cold in nature.[major function]
Clearing heat and promoting diuresis, removing blood stasis and hemostasis, removing toxic substances.Main flu, cough, blood-stained sputum, dysentery, diarrhea, dysmenorrhea, irregular menstruation, bruise wound is swollen,
Traumatic hemorrhage, ulcerative carbuncle pyogenic infections.
Mountain Radix Glycyrrhizae: [source] is the cauline leaf of madder wort hair Radix Mussaendae.[nature and flavor] are sweet, and slight bitter is cool.[channel tropism] returns wing
Guang, lung, large intestine channel.[major function] clearing heat and promoting diuresis, removing toxicity for detumescence.Main flu, heatstroke are generated heat, cough, abscess of throat, diarrhea,
Dysentery, nephritic dropsy, damp and hot difficult urination, sore abscess, venomous snake bite.
Shrub althea flower: [source] is the flower of the malvaceae plant rose of Sharon.[nature and flavor] are sweet, bitter, cool.[channel tropism] lung, spleen, Liver Channel
[major function] clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body.Main intestines wind rushes down blood, red white diarrhea, hemorrhoid hemorrhage, cough with lung heat, and hemoptysis is white
Band, boil carbuncle swells, scald.
Fourth last of the ten Heavenly stems grass: [source] is the herb of leguminous plant fourth last of the ten Heavenly stems grass.[nature and flavor] are sweet in flavor, cool in nature.[channel tropism] returns spleen, Liver Channel.
[major function] relieving superficies by cooling, removing pattogenic heat from the blood and toxic material from the body, dehumidify diuresis.Main anemopyretic cold, pharyngalgia, hot eyes, acute mastitis, sore swollen toxin, poisonous snake
It bites, jaundice, diarrhea, dysentery, infantile malnutrition.
Monochoria vaginalis: [source] is the herb of Pontederiaceae plant Monochoria vaginalis.[nature and flavor] are bitter, cool.[major function] heat-clearing is cool
Blood, diuresis removing toxic substances.Main flu high fever, lung heat cough and asthma, pertussis, hemoptysis are spitted blood, metrorrhagia and metrostaxis, hematuria, heat gonorrhea, dysentery, enteritis, intestines
Carbuncle, erysipelas, sore swells, abscess of throat, swelling and aching of gum, wind-fire red eye, venomous snake bite, malicious mushroom poisoning.
Henry hemsleya root: [source] is the root tuber that cucurbitaceous plant stick hammers melon into shape.[nature and flavor] bitter, it is puckery, it is cold in nature.[major function] is clear
Thermal detoxification, analgesic.Main bacillary dysentery, enteritis, gastritis, sphagitis, parotitis, periodontitis, epidemic conjunctivitis, tonsillitis, high fever, urinary tract
Infection.
Toxin-Vanquishing grass: [source] is the rhizome or herb of Hemionitidaceae plant Er Yejinmao psilophyton.[nature and flavor] are bitter, tremble with fear.[function
Cure mainly] to detoxify, eliminating dampness is antipruritic.Main wind toxin sore, eczema, leukorrhagia.
Chicken bone bavin: [source] is the root that caprifoliaceae plant removes southern double shield wood.[nature and flavor] bitter, it is mild-natured.[major function] hair
Table promoting eruption, detoxifying and relieving itching.Djumah rash acne poison, damp and hot body are itched, and naked wind is worn.
Asparagus fern: [source] is root tuber or the complete stool of liliaceous plant asparagus fern.[nature and flavor] are sweet in flavor, and slight bitter is cold in nature.[function master
Control] moistening lung to arrest cough, cool blood is treating stranguria.Main the lung-dryness syndrome due to yin deficiency is coughed, hemoptysis, dribbling urination.
The weight fraction ratio of each raw medicinal material is as follows in the Chinese medicine: 20~30 parts of moellendorf spikemoss herb, 15~25 parts of common nepenthes, and match
15~25 parts of certain herbaceous plants with big flowers, 5~15 parts of puberulous glochidion branchlet and leaf, 10~20 parts of swertia mileensis, 35~45 parts of setose abelmoschus root, 5~15 parts of Canton love-pea vine, emerald green cloud
35~45 parts of grass, 20~30 parts of hupeh bauhinia root, 10~20 parts of nepal pennywort herb, 10~20 parts of mountain Radix Glycyrrhizae, 20~30 parts of shrub althea flower, the fourth last of the ten Heavenly stems
15~25 parts of grass, 15~25 parts of Monochoria vaginalis, 5~15 parts of henry hemsleya root, 10~20 parts of Toxin-Vanquishing grass, 5~15 parts of chicken bone bavin and asparagus fern 10
~20 parts.
The weight fraction ratio of each raw medicinal material can be preferred in the Chinese medicine are as follows: and 20~25 parts of moellendorf spikemoss herb, common nepenthes 15~
20 parts, 15~20 parts of Herba Malvastri Coromandeliani, 5~10 parts of puberulous glochidion branchlet and leaf, 10~15 parts of swertia mileensis, 35~40 parts of setose abelmoschus root, Canton love-pea vine 5~10
Part, 35~40 parts of Uncinata Spikemoss Herb, 20~25 parts of hupeh bauhinia root, 10~15 parts of nepal pennywort herb, 10~15 parts of mountain Radix Glycyrrhizae, shrub althea flower 20~25
Part, 15~20 parts of fourth last of the ten Heavenly stems grass, 15~20 parts of Monochoria vaginalis, 5~10 parts of henry hemsleya root, 10~15 parts of Toxin-Vanquishing grass, 5~10 parts of chicken bone bavin and
10~15 parts of asparagus fern.
The weight fraction ratio of each raw medicinal material can also be preferred in the Chinese medicine are as follows: and 23 parts of moellendorf spikemoss herb, 18 parts of common nepenthes, match
It is 16 parts of certain herbaceous plants with big flowers, 8 parts of puberulous glochidion branchlet and leaf, 12 parts of swertia mileensis, 37 parts of setose abelmoschus root, 6 parts of Canton love-pea vine, 39 parts of Uncinata Spikemoss Herb, 24 parts of hupeh bauhinia root, red
13 parts of membranaceous marshmarigold herb, 14 parts of mountain Radix Glycyrrhizae, 23 parts of shrub althea flower, 19 parts of fourth last of the ten Heavenly stems grass, 16 parts of Monochoria vaginalis, 7 parts of henry hemsleya root, 12 parts of Toxin-Vanquishing grass,
6 parts and 14 parts of asparagus fern of chicken bone bavin.
The weight fraction ratio of each raw medicinal material can also be preferred in the Chinese medicine are as follows: and 25 parts of moellendorf spikemoss herb, 16 parts of common nepenthes, match
It is 19 parts of certain herbaceous plants with big flowers, 6 parts of puberulous glochidion branchlet and leaf, 14 parts of swertia mileensis, 40 parts of setose abelmoschus root, 8 parts of Canton love-pea vine, 36 parts of Uncinata Spikemoss Herb, 22 parts of hupeh bauhinia root, red
11 parts of membranaceous marshmarigold herb, 12 parts of mountain Radix Glycyrrhizae, 24 parts of shrub althea flower, 17 parts of fourth last of the ten Heavenly stems grass, 18 parts of Monochoria vaginalis, 8 parts of henry hemsleya root, 15 parts of Toxin-Vanquishing grass,
8 parts and 13 parts of asparagus fern of chicken bone bavin.
The present invention also provides the preparation method of above-mentioned Chinese medicine, the dosage form of the Chinese medicine is suppository, and preparation method includes
Following steps:
Step 1: the raw material is soaked in water 30 minutes to 1 hour, heating is boiled 50~60 minutes, is filtered, and filtrate is standby
With；Filter residue, which adds second of water, to be heated, and is boiled 30~40 minutes, is filtered, filtrate is spare；Filter residue adds water, and third time heating is boiled
20~30 minutes, filtering；It filtrate will be combined three times, heating is concentrated into paste, is put into cooling, grinding after 70 DEG C of baking oven drying
At fine powder.
Step 2: taking a kind of in semi-synthetic fatty glyceride, lanolin, polyethylene glycol and poloxamer poloxamer
Or it is a variety of as matrix；By the matrix under the conditions of temperature 60 C~70 DEG C heating and melting, be added the first step obtained by fine powder, water
Bath stirs evenly, and is mixed into sticky liquid, is poured in plastic shape-forming pipe, is inserted into tampon, and bullet-shaped is made in cooling and shaping
Suppository；The proportion of the fine powder and matrix is 1: 3~1: 5；The tampon is the tampon that tail portion has cotton thread.
The present invention also provides the preparation method of above-mentioned Chinese medicine, the dosage form of the Chinese medicine is washing lotion, and preparation method includes
Following steps:
Step 1: the raw medicinal material is mixed in proportion, it is put into micronizer that be ground into 0.1~10 μm of volume flat
The micron particles and partial size of equal partial size are described less than the mixed powder that the nano-scale particle of 0.1 μm of volume average particle size forms
The powder rate that obtains of mixed powder is at least 97%；
Step 2: 3~5 times of quality of the alcohol relative to the mixed powder is added in the mixed powder that the first step obtains
The ethyl alcohol that concentration is 70%~80%, stirring and dissolving obtain ethanol solution, ethanol solution are stood under conditions of 5 DEG C~10 DEG C
24~36 hours, using percolation with the speed of 1~2ml per minute, slowly diacolation, collection percolate were concentrated and dried, and
This is put into micronizer and crushes 30~60 minutes, obtains the micron particles and partial size of 0.1~10 μm of volume average particle size
Less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of the mixed powder is at least
97%；
Step 3: the deionization relative to 5~7 times of mixed powder quality is added in the mixed powder that second step obtains
Water decocts 1~3 hour, and filtering obtains decoction.
The present invention will be described in detail below with reference to the drawings of preferred embodiments, fully understands the present invention how using skill whereby
Art means solve technical problem, reach technical effect and implement accordingly.
1 suppository of embodiment
Take the weight fraction ratio of each raw medicinal material in the Chinese medicine can also be preferred are as follows: moellendorf spikemoss herb 230g, common nepenthes 180g,
Herba Malvastri Coromandeliani 160g, puberulous glochidion branchlet and leaf 80g, swertia mileensis 120g, setose abelmoschus root 370g, Canton love-pea vine 60g, Uncinata Spikemoss Herb 390g, hupeh bauhinia root 240g,
Nepal pennywort herb 130g, mountain Radix Glycyrrhizae 140g, shrub althea flower 230g, fourth last of the ten Heavenly stems grass 190g, Monochoria vaginalis 160g, henry hemsleya root 70g, Toxin-Vanquishing grass
120g, chicken bone bavin 60g and asparagus fern 140g；
It prepares according to the following steps:
Step 1: the raw material is soaked in water 1 hour, heating is boiled 60 minutes, is filtered, and filtrate is spare；Filter residue adds water
Second of heating, boils 40 minutes, filters, and filtrate is spare；Filter residue adds water, and third time heating is boiled 30 minutes, filters；By three
Secondary filtrate is combined, and heating is concentrated into paste, is put into cooling after 70 DEG C of baking oven drying, is ground into fine powder.
Step 2: taking semi-synthetic fatty glyceride, polyethylene glycol and poloxamer poloxamer, mixed by 1:1:2,
As matrix；By the matrix under the conditions of temperature 70 C heating and melting, be added the first step obtained by fine powder, stirring in water bath is uniform,
It is mixed into sticky liquid, is poured in plastic shape-forming pipe, tampon is inserted into, bullet-shaped suppository is made in cooling and shaping；It is described thin
The proportion of powder and matrix is 1: 3；The tampon is the tampon that tail portion has cotton thread.
2 washing lotion of embodiment
Moellendorf spikemoss herb 250g, common nepenthes 160g, Herba Malvastri Coromandeliani 190g, puberulous glochidion branchlet and leaf 60g, swertia mileensis 140g, setose abelmoschus root 400g are taken,
Canton love-pea vine 80g, Uncinata Spikemoss Herb 360g, hupeh bauhinia root 220g, nepal pennywort herb 110g, mountain Radix Glycyrrhizae 120g, shrub althea flower 240g, fourth last of the ten Heavenly stems grass
170g, Monochoria vaginalis 180g, henry hemsleya root 80g, Toxin-Vanquishing grass 150g, chicken bone bavin 80g and asparagus fern 130g.
It prepares according to the following steps:
Step 1: the raw medicinal material is mixed in proportion, it is put into micronizer and is ground into 5 μm of volume average particle sizes
Micron particles and partial size less than the mixed powder that the nano-scale particle of 0.1 μm of volume average particle size forms, the mixed powder
The powder rate that obtains of material is at least 97%；
Step 2: being added in the mixed powder that the first step obtains pure and strong relative to 5 times of quality of the mixed powder
The ethyl alcohol that degree is 80%, stirring and dissolving obtain ethanol solution, ethanol solution are stood 36 hours under conditions of 10 DEG C, using infiltration
With the speed of 2ml per minute, slowly diacolation, collection percolate are concentrated and dried, and be put into powder in micronizer herein method of filtering
Broken 60 minutes, obtain 2 μm of volume average particle sizes micron particles and partial size less than 0.1 μm of volume average particle size nanoscale
The powder rate that obtains of the mixed powder of grain composition, the mixed powder is at least 97%；
Step 3: the deionized water relative to 5 times of mixed powder quality is added in the mixed powder that second step obtains, decoct
It boils 2 hours, filters, obtain decoction.
Toxicity test:
1, experimental method: depilatory agent is uniformly coated with by guinea pig back backbone two sides, makes about 40 square centimeters of unhairing range.It washes
Net depilatory agent returns cage to observe 24 hours, and every group of cavy applies the distillation water diluent 0.3,0.5 of Chinese materia medica preparation suppository of the present invention respectively
And 0.8ml, 110mg containing crude drug, 183mg and 293mg, another group of painting solvent 0.8ml twice a day, continuous one week, are tested respectively
After, cavy is put to death, the heart, liver, kidney and depilation skin do pathological examination.
2, result: above-mentioned three groups of medications cavy trunk hair removal section has no that local skin has oedema, hyperemia, erythema, blutpunkte
And ulcer.Medication group cavy chroma of hair is ingested, the control groups no significant difference such as four limbs activity, histopathologic examination, administration
The group heart, liver, kidney and depilation the skin also no significant difference compared with compareing word.
As a result it prompts, traditional Chinese medicine for external application of the present invention also has no that general toxicity shows without local irritant effect.Show this hair
Bright traditional Chinese medicine for external application uses safe.
Clinical data:
Case selection: all 122 cases are in December, 2010~2013 year our hospital in November out-patient.By patient with
Machine is divided into treatment group and control group, wherein 62 people for the treatment of group, the age 15~50 years old, average (32.5 ± 3.8) year, nullipara 14
Example, multipara 48.60 people of control group, the age 16~52 years old, average (33.4 ± 4.3) year, nullipara 10, multipara 50
Example.Two groups the age, the course of disease, symptom, coincident with severity degree of condition and in terms of through statistical analysis without significant
Sex differernce (p > 0.05).
BV diagnostic criteria: (1) vaginal fluid homogeneous lean；(2) experiment of vaginal fluid amine is positive；(3) vagina pH >
4.5；(4) discover a clue cell.Have 2 in first 3, while to account for 10% or more i.e. diagnosable for clues cell.
Treatment method:
Control group: before sleeping after cleaning vulva, first nitre file bolt 500mg is set in vagina depths, one time a day, is used in conjunction 20 days and treats for 1
Journey.
Treatment group: before sleeping after cleaning vulva, 1 suppository of Chinese medicine embodiment of the present invention is set in vagina depths, one time a day, is used in conjunction
20 days are 1 course for the treatment of.
Curative effect judging standard: two group objects check vaginal secretion after 2 weeks and next clean period after treating 1 course for the treatment of
Object.Recovery from illness: 4 negative, clinical symptoms disappearances in BV diagnostic criteria.It is effective: only 1 positive in BV diagnostic criteria, clinical condition
Shape disappears.Effective: only 2 positives, clinical symptoms are obviously improved in BV diagnostic criteria.It is invalid: 3 positives in BV diagnostic criteria,
Clinical symptoms are without improvement.
Treatment results: it is shown in Table 1.
1 two groups of patient's total effects of table compare
| Group | n | Recovery from illness | It is effective | Effectively | In vain | It is total effective |
| Treatment group | 62 | 36 | 18 | 6 | 2 | 60 (96.77%) |
| Control group | 60 | 22 | 20 | 14 | 12 | 48 (80.00%) |
Note: two groups of total effective rates compare p < 0.05, and treatment group's curative effect is better than control group.
Two groups of recurrence rates compare:
It chooses treatment group and control group recovery from illness case carries out relapse rate, control group has 4 people recurrence, and recurrence rate is
18.18% (4/22)；There is 1 people recurrence in treatment group, and recurrence rate is 2.78% (1/36).Difference is statistically significant (p < 0.05),
Treatment group's recurrence rate is lower than control group.
Specific case: Sun, women, 35 years old, multipara.On March 25th, 2013 is medical because of pruritus of vagina.It checks: vagina
Secretion homogeneous lean, vaginal fluid amine test positive vaginal pH 5.0, and discover a clue cell.It is diagnosed as bacterial vaginosis
It is scorching.Give 1 suppository of Chinese medicine embodiment of the present invention one time a day, continuous 15 days, recovery from illness, follow-up half a year did not recurred.
The above described is only a preferred embodiment of the present invention, being not that the invention has other forms of limitations, appoint
What those skilled in the art changed or be modified as possibly also with the technology contents of the disclosure above equivalent variations etc.
Imitate embodiment.But without departing from the technical solutions of the present invention, according to the technical essence of the invention to above embodiments institute
Any simple modification, equivalent variations and the remodeling made, still fall within the protection scope of technical solution of the present invention.
Claims (7)
1. a kind of Chinese medicine for treating bacterial vaginitis, which is characterized in that the parts by weight of each raw medicinal material of Chinese medicine are such as
Under: 20~30 parts of moellendorf spikemoss herb, 15~25 parts of common nepenthes, 15~25 parts of Herba Malvastri Coromandeliani, 5~15 parts of puberulous glochidion branchlet and leaf, 10~20 parts of swertia mileensis,
35~45 parts of setose abelmoschus root, 5~15 parts of Canton love-pea vine, 35~45 parts of Uncinata Spikemoss Herb, 20~30 parts of hupeh bauhinia root, nepal pennywort herb 10~20
Part, 10~20 parts of mountain Radix Glycyrrhizae, 20~30 parts of shrub althea flower, 15~25 parts of fourth last of the ten Heavenly stems grass, 15~25 parts of Monochoria vaginalis, 5~15 parts of henry hemsleya root,
10~20 parts of Toxin-Vanquishing grass, 5~15 parts and 10~20 parts of asparagus fern of chicken bone bavin.
2. Chinese medicine as described in claim 1, which is characterized in that the weight fraction ratio of each raw medicinal material of Chinese medicine is as follows: ground
20~25 parts of cypress branch, 15~20 parts of common nepenthes, 15~20 parts of Herba Malvastri Coromandeliani, 5~10 parts of puberulous glochidion branchlet and leaf, 10~15 parts of swertia mileensis, Huang Qiu
35~40 parts of certain herbaceous plants with big flowers root, 5~10 parts of Canton love-pea vine, 35~40 parts of Uncinata Spikemoss Herb, 20~25 parts of hupeh bauhinia root, 10~15 parts of nepal pennywort herb, mountain
10~15 parts of Radix Glycyrrhizae, 20~25 parts of shrub althea flower, 15~20 parts of fourth last of the ten Heavenly stems grass, 15~20 parts of Monochoria vaginalis, 5~10 parts of henry hemsleya root, Toxin-Vanquishing
10~15 parts of grass, 5~10 parts and 10~15 parts of asparagus fern of chicken bone bavin.
3. Chinese medicine as described in claim 1, which is characterized in that the weight fraction ratio of each raw medicinal material of Chinese medicine is as follows: ground
It is 23 parts of cypress branch, 18 parts of common nepenthes, 16 parts of Herba Malvastri Coromandeliani, 8 parts of puberulous glochidion branchlet and leaf, 12 parts of swertia mileensis, 37 parts of setose abelmoschus root, 6 parts of Canton love-pea vine, emerald green
39 parts of cloud grass, 24 parts of hupeh bauhinia root, 13 parts of nepal pennywort herb, 14 parts of mountain Radix Glycyrrhizae, 23 parts of shrub althea flower, 19 parts of fourth last of the ten Heavenly stems grass, 16 parts of Monochoria vaginalis,
7 parts of henry hemsleya root, 12 parts of Toxin-Vanquishing grass, 6 parts and 14 parts of asparagus fern of chicken bone bavin.
4. the Chinese medicine as described in claims 1 to 3 any one, which is characterized in that the dosage form of the Chinese medicine is suppository, preparation
Method the following steps are included:
Step 1: the raw material is soaked in water 30 minutes to 1 hour, heating is boiled 50~60 minutes, is filtered, and filtrate is spare；
Filter residue, which adds second of water, to be heated, and is boiled 30~40 minutes, is filtered, filtrate is spare；Filter residue adds water, and third time heating boils 20~
30 minutes, filtering；It filtrate will be combined three times, heating is concentrated into paste, is put into cooling after 70 DEG C of baking oven drying, is ground into thin
Powder.
Step 2: taking a kind of or more in semi-synthetic fatty glyceride, lanolin, polyethylene glycol and poloxamer poloxamer
Kind is used as matrix；By the matrix, heating and melting, addition first step gained fine powder, water-bath are stirred under the conditions of temperature 60 C~70 DEG C
It mixes uniformly, is mixed into sticky liquid, is poured in plastic shape-forming pipe, be inserted into tampon, bullet-shaped suppository is made in cooling and shaping；
The proportion of the fine powder and matrix is 1: 3~1: 5；The tampon is the tampon that tail portion has cotton thread.
5. the Chinese medicine as described in claims 1 to 3 any one, which is characterized in that the dosage form of the Chinese medicine is washing lotion, preparation
Method the following steps are included:
Step 1: the raw medicinal material is mixed in proportion, it is put into micronizer and is ground into 0.1~10 μm of volume and is averaged grain
Mixed powder of the micron particles and partial size of diameter less than the nano-scale particle composition of 0.1 μm of volume average particle size, the mixing
The powder rate that obtains of powder is at least 97%；
Step 2: 3~5 times of quality of the determining alcohol relative to the mixed powder is added in the mixed powder that the first step obtains
For 70%~80% ethyl alcohol, stirring and dissolving obtains ethanol solution, ethanol solution stands to 24 under conditions of 5 DEG C~10 DEG C~
36 hours, using percolation with the speed of 1~2ml per minute, slowly diacolation, collection percolate were concentrated and dried, and put herein
Enter in micronizer and crush 30~60 minutes, the micron particles and partial size for obtaining 0.1~10 μm of volume average particle size are less than
The powder rate that obtains of the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the mixed powder is at least 97%；
Step 3: the deionized water relative to 5~7 times of mixed powder quality is added in the mixed powder that second step obtains, decoct
It boils 1~3 hour, filters, obtain decoction.
6. a kind of preparation method of Chinese medicine described in claims 1 to 3 any one, which is characterized in that the dosage form of the Chinese medicine is
Suppository, preparation method includes the following steps:
Step 1: the raw material is soaked in water 30 minutes to 1 hour, heating is boiled 50~60 minutes, is filtered, and filtrate is spare；
Filter residue, which adds second of water, to be heated, and is boiled 30~40 minutes, is filtered, filtrate is spare；Filter residue adds water, and third time heating boils 20~
30 minutes, filtering；It filtrate will be combined three times, heating is concentrated into paste, is put into cooling after 70 DEG C of baking oven drying, is ground into thin
Powder.
Step 2: taking a kind of or more in semi-synthetic fatty glyceride, lanolin, polyethylene glycol and poloxamer poloxamer
Kind is used as matrix；By the matrix, heating and melting, addition first step gained fine powder, water-bath are stirred under the conditions of temperature 60 C~70 DEG C
It mixes uniformly, is mixed into sticky liquid, is poured in plastic shape-forming pipe, be inserted into tampon, bullet-shaped suppository is made in cooling and shaping；
The proportion of the fine powder and matrix is 1: 3~1: 5；The tampon is the tampon that tail portion has cotton thread.
7. a kind of preparation method of Chinese medicine described in claims 1 to 3 any one, which is characterized in that the dosage form of the Chinese medicine is
Washing lotion, preparation method includes the following steps:
Step 1: the raw medicinal material is mixed in proportion, it is put into micronizer and is ground into 0.1~10 μm of volume and is averaged grain
Mixed powder of the micron particles and partial size of diameter less than the nano-scale particle composition of 0.1 μm of volume average particle size, the mixing
The powder rate that obtains of powder is at least 97%；
Step 2: 3~5 times of quality of the determining alcohol relative to the mixed powder is added in the mixed powder that the first step obtains
For 70%~80% ethyl alcohol, stirring and dissolving obtains ethanol solution, ethanol solution stands to 24 under conditions of 5 DEG C~10 DEG C~
36 hours, using percolation with the speed of 1~2ml per minute, slowly diacolation, collection percolate were concentrated and dried, and put herein
Enter in micronizer and crush 30~60 minutes, the micron particles and partial size for obtaining 0.1~10 μm of volume average particle size are less than
The powder rate that obtains of the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the mixed powder is at least 97%；
Step 3: the deionized water relative to 5~7 times of mixed powder quality is added in the mixed powder that second step obtains, decoct
It boils 1~3 hour, filters, obtain decoction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710746210.9A CN109419996A (en) | 2017-08-26 | 2017-08-26 | A kind of Chinese medicine that treating bacterial vaginitis and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710746210.9A CN109419996A (en) | 2017-08-26 | 2017-08-26 | A kind of Chinese medicine that treating bacterial vaginitis and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109419996A true CN109419996A (en) | 2019-03-05 |
Family
ID=65499668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710746210.9A Withdrawn CN109419996A (en) | 2017-08-26 | 2017-08-26 | A kind of Chinese medicine that treating bacterial vaginitis and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109419996A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104013738A (en) * | 2014-06-15 | 2014-09-03 | 张晓燕 | Traditional Chinese medicine for treating bacterial vaginosis and preparation method of traditional Chinese medicine |
| CN104706914A (en) * | 2015-02-28 | 2015-06-17 | 魏霞 | Traditional Chinese medicine for treating bacterial vaginitis and preparation method |
-
2017
- 2017-08-26 CN CN201710746210.9A patent/CN109419996A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104013738A (en) * | 2014-06-15 | 2014-09-03 | 张晓燕 | Traditional Chinese medicine for treating bacterial vaginosis and preparation method of traditional Chinese medicine |
| CN104706914A (en) * | 2015-02-28 | 2015-06-17 | 魏霞 | Traditional Chinese medicine for treating bacterial vaginitis and preparation method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102091203B (en) | External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof | |
| CN101804166B (en) | Traditional Chinese medicine composition for treating dermatitis and eczema of infants | |
| CN103751633B (en) | A kind of Chinese medicine composition and its preparation method treating Varicose veins of lower extremity | |
| CN104351563A (en) | Functional feed used for preventing pig malignant edema and preparation method of functional feed | |
| CN105662996A (en) | Traditional Chinese medicine mask for treating menstruation-associated acne | |
| CN105028315B (en) | A kind of testudinate hatching material and preparation method thereof | |
| CN109419996A (en) | A kind of Chinese medicine that treating bacterial vaginitis and preparation method | |
| CN102579818A (en) | Traditional Tibetan medicine composition, preparation method thereof and application | |
| CN105797112A (en) | Feed additive with release effect and capable of treating sow metritis | |
| CN110201128A (en) | A kind of Chinese materia medica preparation and preparation method thereof for treating intermingled phlegm and blood stasis type acne | |
| CN105055622B (en) | A kind of Chinese medicine film-forming gel agent treating either shallow bed sore at ulcerative stage | |
| CN104922449A (en) | Traditional Chinese medicine disinfection solution and preparation method thereof | |
| CN104706914B (en) | A kind of Chinese medicine and preparation method for the treatment of bacterial vaginitis | |
| CN103656323A (en) | Traditional Chinese medicine for treating erythroderma-type psoriasis | |
| CN104606501B (en) | A kind of Chinese medicine for the treatment of damp-heat type abdominal postoperative urine retention | |
| CN103181964B (en) | Traditional Chinese medicine composition for treating animal body surface injuries and preparation method thereof | |
| CN105287775A (en) | Method for preparing traditional Chinese medicine preparation capable of treating suppurative otitis media through external application | |
| CN105343211A (en) | Traditional Chinese medicine preparation for treating otitis media suppurative through external application | |
| CN106880758A (en) | It is a kind of for pruritus vulvue and the Chinese medicine preparation and preparation method of eczema stubborn dermatitis | |
| CN105661053A (en) | Plant sheep feed additive | |
| CN105919884A (en) | Anti-dandruff traditional Chinese medicine composition containing Adiantum leaf and for cosmetics | |
| CN105944049A (en) | Feed additive capable of treating sow metritis and preparation method of feed additive | |
| CN103933515A (en) | Traditional Chinese medicine for treating prostatitis and preparation method thereof | |
| CN105125781A (en) | Traditional Chinese medicine gel for treating stage-III pressure sore and preparing method of traditional Chinese medicine gel | |
| CN108339044A (en) | Treat the pharmaceutical composition and preparation method thereof of cervical erosion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190305 |