CN104706914A - Traditional Chinese medicine for treating bacterial vaginitis and preparation method - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating bacterial vaginitis and a preparation method. The traditional Chinese medicine comprises the following raw materials: moellendorfspikemoss herbs, nepenthes, coromandel coast falsemallow, puberulousglochidionbranchlet and leaves, mile swertia herbs, setoseabelmoschus roots, abruscantoniensis, selaginellauncinata spring, Hupeh bauhinia roots, hydrocotylenepalensis, twigs and leaves of Buddha's lamp, shrubalthea flowers, twinleaf zornia herbs, sheathed monochoria herbs, entireleafneoalsomitra, Lythrumy, lsholtziafruticosa and asparagus. The traditional Chinese medicine disclosed by the invention has an exactcurative effect on treating the bacterial vaginitis, has small toxic and side effects, and is not easy to recur.

Description

A kind of Chinese medicine and preparation method for the treatment of bacterial vaginitis

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of bacterial vaginitis.

Background technology

Bacterial vaginitis (BV) is one of common gynecological inflammation, and be mixed bacterial infection, main manifestations is that vaginal secretions increases, stench.Can have slight pruritus vulvae or burn feeling, easily recur, have infectiousness, 10-40% patient, without clinical symptoms, has a strong impact on patients ' life quality.

The feature of BV is the change of vaginal environment, namely advantage lactobacillus replace by a large amount of pathogenic anaerobic bacteria, therefore clinically to treat mainly with to anaerobe effective first nitre file.The most effectively treatment is first-selected oral first nitre file, but because oral first nitre file gastrointestinal reaction is large, patient should not accept maybe to adhere to treatment, tend to vagina local application in recent years, think that medicine directly applies to pathogen, there is good effect equally, can also side reaction be reduced, but still still have certain side effect.

Bacterial vaginitis belongs to Chinese medicine " leukorrhagia " category.Mainly dampness-heat of the liver or stagnation of liver-QI with deficiency of the spleen, damp invasion of lower energizer, caused by pent-up external genitals.Therapeutic Principle is removing damp-heat, removing pathogenic heat from blood and toxic substance from the body, sterilizing and itch-relieving.

Summary of the invention

Technical problem to be solved by this invention is, provide a kind of Chinese medicine and preparation method for the treatment of bacterial vaginitis, Chinese medicine of the present invention has definite curative effect to bacterial vaginitis, and toxic and side effects is little, not easily recurs.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of bacterial vaginitis, its raw medicinal material comprises: Herba Selaginellae Moellendorfii, Herba nepenthis, Herba Malvastri Coromandeliani, Folium glochidionis puberi, Herba Swertiae Mileensis, Radix abelmoschi pungentis, Herba Abri, CUIYUNCAO, Radix Bauhiniae Hupehanae, Herba Hydrocotylis Nepalensis, Ramulus et Folium Mussaendae Pubescentis, Flos Hibisci, Herba Zornia Diphyllae, Herba monochoriae vaginalis, Neoalsomitra integrifoliola (Cogn.) Hucth., relieve internal heat grass, Os Gallus domesticus bavin and Herba Asparagi Setacei.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Selaginellae Moellendorfii 20 ~ 30 parts, Herba nepenthis 15 ~ 25 parts, Herba Malvastri Coromandeliani 15 ~ 25 parts, Folium glochidionis puberi 5 ~ 15 parts, Herba Swertiae Mileensis 10 ~ 20 parts, Radix abelmoschi pungentis 35 ~ 45 parts, Herba Abri 5 ~ 15 parts, CUIYUNCAO 35 ~ 45 parts, Radix Bauhiniae Hupehanae 20 ~ 30 parts, Herba Hydrocotylis Nepalensis 10 ~ 20 parts, Ramulus et Folium Mussaendae Pubescentis 10 ~ 20 parts, Flos Hibisci 20 ~ 30 parts, Herba Zornia Diphyllae 15 ~ 25 parts, Herba monochoriae vaginalis 15 ~ 25 parts, Neoalsomitra integrifoliola (Cogn.) Hucth. 5 ~ 15 parts, relieve internal heat grass 10 ~ 20 parts, Os Gallus domesticus bavin 5 ~ 15 parts and Herba Asparagi Setacei 10 ~ 20 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Selaginellae Moellendorfii 20 ~ 25 parts, Herba nepenthis 15 ~ 20 parts, Herba Malvastri Coromandeliani 15 ~ 20 parts, Folium glochidionis puberi 5 ~ 10 parts, Herba Swertiae Mileensis 10 ~ 15 parts, Radix abelmoschi pungentis 35 ~ 40 parts, Herba Abri 5 ~ 10 parts, CUIYUNCAO 35 ~ 40 parts, Radix Bauhiniae Hupehanae 20 ~ 25 parts, Herba Hydrocotylis Nepalensis 10 ~ 15 parts, Ramulus et Folium Mussaendae Pubescentis 10 ~ 15 parts, Flos Hibisci 20 ~ 25 parts, Herba Zornia Diphyllae 15 ~ 20 parts, Herba monochoriae vaginalis 15 ~ 20 parts, Neoalsomitra integrifoliola (Cogn.) Hucth. 5 ~ 10 parts, relieve internal heat grass 10 ~ 15 parts, Os Gallus domesticus bavin 5 ~ 10 parts and Herba Asparagi Setacei 10 ~ 15 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Selaginellae Moellendorfii 23 parts, Herba nepenthis 18 parts, Herba Malvastri Coromandeliani 16 parts, Folium glochidionis puberi 8 parts, Herba Swertiae Mileensis 12 parts, Radix abelmoschi pungentis 37 parts, Herba Abri 6 parts, CUIYUNCAO 39 parts, Radix Bauhiniae Hupehanae 24 parts, Herba Hydrocotylis Nepalensis 13 parts, Ramulus et Folium Mussaendae Pubescentis 14 parts, Flos Hibisci 23 parts, Herba Zornia Diphyllae 19 parts, Herba monochoriae vaginalis 16 parts, Neoalsomitra integrifoliola (Cogn.) Hucth. 7 parts, relieve internal heat grass 12 parts, Os Gallus domesticus bavin 6 parts and Herba Asparagi Setacei 14 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Selaginellae Moellendorfii 25 parts, Herba nepenthis 16 parts, Herba Malvastri Coromandeliani 19 parts, Folium glochidionis puberi 6 parts, Herba Swertiae Mileensis 14 parts, Radix abelmoschi pungentis 40 parts, Herba Abri 8 parts, CUIYUNCAO 36 parts, Radix Bauhiniae Hupehanae 22 parts, Herba Hydrocotylis Nepalensis 11 parts, Ramulus et Folium Mussaendae Pubescentis 12 parts, Flos Hibisci 24 parts, Herba Zornia Diphyllae 17 parts, Herba monochoriae vaginalis 18 parts, Neoalsomitra integrifoliola (Cogn.) Hucth. 8 parts, relieve internal heat grass 15 parts, Os Gallus domesticus bavin 8 parts and Herba Asparagi Setacei 13 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is suppository, and its preparation method comprises the following steps:

The first step: described raw material is soaked 30 minutes to 1 hour, heated and boiled 50 ~ 60 minutes, filter, filtrate is for subsequent use; The second time that adds water filtering residue heats, and boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 20 ~ 30 minutes, filters; Three filtrates be combined, heating is concentrated into pasty state, puts into after 70 DEG C, baking oven is dried and cools, grind to form fine powder.

Second step: to get in semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol and poloxamer poloxamer one or more as substrate; By described substrate heating and melting under DEG C condition of temperature 60 C ~ 70, add first step gained fine powder, stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described fine powder and substrate is 1: 3 ~ 1: 5; Described tampon is the tampon of afterbody with cotton thread.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is washing liquid, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 97%;

Second step: adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 70% ~ 80%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 30 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 97%,

3rd step: add the deionized water relative to mixed powder quality 5 ~ 7 times in the mixed powder that second step obtains, decoct 1 ~ 3 hour, filter, obtain medicine juice.

Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to bacterial vaginitis, and toxic and side effects is little, not easily recurs.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of bacterial vaginitis, its raw medicinal material comprises: Herba Selaginellae Moellendorfii, Herba nepenthis, Herba Malvastri Coromandeliani, Folium glochidionis puberi, Herba Swertiae Mileensis, Radix abelmoschi pungentis, Herba Abri, CUIYUNCAO, Radix Bauhiniae Hupehanae, Herba Hydrocotylis Nepalensis, Ramulus et Folium Mussaendae Pubescentis, Flos Hibisci, Herba Zornia Diphyllae, Herba monochoriae vaginalis, Neoalsomitra integrifoliola (Cogn.) Hucth., relieve internal heat grass, Os Gallus domesticus bavin and Herba Asparagi Setacei.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Herba Selaginellae Moellendorfii: [source] is the herb of Spikemoss plant Herba Selaginellae Involventis.[nature and flavor] are sweet, pungent, flat.[return through] returns liver, gallbladder, lung meridian.[function cures mainly] clearing away heat-damp and promoting diuresis, hemostasis.Main lung-heat spitting of blood, spit blood, epistaxis, has blood in stool, bleeding hemorrhoids, traumatic hemorrhage, heating, infantile convulsion, jaundice due to damp-heat, gonorrhea, edema, burn due to hot liquid or fire.

Herba nepenthis: [source] is the stem and leaf of Nepenthaceae plant Herba nepenthis.[nature and flavor] are sweet, light, cool.[return through] returns lung, gallbladder, stomach warp.[function cures mainly] nourishing the lung to arrest cough, clearing away heat-damp and promoting diuresis calculus, removing toxic substances and promoting subsidence of swelling.Main dryness of the lung hemoptysis, cold cough, pertussis, jaundice, dysentery, lithangiuria, also can be used for gastric and duodenal ulcers, hypertension, diabetes, skin infection carbuncle.

Herba Malvastri Coromandeliani: [source] is the herb of Malvaceae plant Herba Malvastri Coromandeliani.[nature and flavor] are micro-sweet, cool.[return through] returns lung, liver, large intestine channel.[function cures mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Main damp-heat dysentery, jaundice, cough due to lung-heat, laryngopharynx swelling and pain, hemorrhoid, carbuncle sore tumefacting virus, traumatic injury, prostatitis.

Folium glochidionis puberi: [source] is the leaf of euphorbia plant Fructus glochidionis puberi(Herba Glochidii Puberi).[nature and flavor] bitter in the mouth is puckery, cool in nature.[return through] returns large intestine channel.[function cures mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Main damp-heat dysentery, jaundice, stranguria with turbid discharge, leukorrhagia, heating, laryngopharynx swelling and pain, carbuncle furuncle swells, dermatitis rhus, eczema, snake bite and insect sting.

Herba Swertiae Mileensis: [source] is the herb of gentianaceae plant Herba Swertiae Mileensis, Herba Swertiae yunnanensis and Herba Swertiae bimaculatae.[nature and flavor] are bitter, cold in nature.[return through] returns liver, gallbladder, urinary bladder channel.[function cures mainly] heat-clearing and toxic substances removing, dampness removing jaundice eliminating.Main jaundice due to damp-heat, the puckery pain of pyretic stranguria, damp-heat dysentery, leucorrhea with red and white discharge, influenza, malaria is generated heat, acute gastritis, acute pharyngolaryngitis, acute tonsillitis.External can control acute conjunctivitis, allergic dermatitis.

Radix abelmoschi pungentis: [source] is the root of Malvaceae plant bristle Abelmoschus esculentus.[nature and flavor] are bitter, cold.[function cures mainly] clearing away heat-damp and promoting diuresis.Harness the river swollen, urinary tract infection.

Herba Abri: [source] is the herb of leguminous plant Guangdong Semen Abri Precatorii.[nature and flavor] are sweet, bitter, cool.[return through] GUIXIN, lung, liver, stomach, kidney channel.[function cures mainly] clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain.Main icterohepatitis, stomachache, rheumatic ostalgia, traumatic injury stasis of blood pain, acute mastitis.

CUIYUNCAO: [source] is the herb of Spikemoss plant CUIYUNCAO.[nature and flavor] are light, micro-hardship, cool.[function cures mainly] clearing away heat-damp and promoting diuresis, removing toxic substances, hemostasis.Main jaundice, dysentery, has loose bowels, edema, gonorrhea, myalgia, and spit blood, hemoptysis, has blood in stool, traumatic hemorrhage, hemorrhoid complicated by anal fistula, burn and scald, venom.

Radix Bauhiniae Hupehanae: the root that [source] is leguminous plant Hubei Province Bauhinia purpurea or stem and leaf.[nature and flavor] are bitter, puckery, flat.[return through] returns kidney, large intestine channel.[function cures mainly] restrains astringent or styptic treatment for spontaneous sweating, removing toxic substances dehumidifying.Main cough spitting of blood, spit blood, have blood in stool, the enuresis, frequent micturition, leucorrhea, uterine prolapse, dysentery, arthralgia pain, hernia, painful and swollen testis, eczema, furuncle swells and ache.

Herba Hydrocotylis Nepalensis: [source] is the herb of samphire Herba Hydrocotylis Nepalensis.[nature and flavor] bitter in the mouth, cold in nature.[function cures mainly] clearing away heat-damp and promoting diuresis, removing stasis to stop bleeding, removing toxic substances.Main flu, cough, sputum mixed with blood, dysentery, has loose bowels, dysmenorrhea, menoxenia, and traumatic injury wound is swollen, traumatic hemorrhage, carbuncle pyogenic infections from tumour or sore.

Ramulus et Folium Mussaendae Pubescentis: [source] is the stem and leaf of Maguireothamnus speciosus hair Radix Mussaendae.[nature and flavor] are sweet, micro-hardship, cool.[return through] returns bladder, lung, large intestine channel.[function cures mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Main flu, heatstroke, heating, cough, laryngopharynx swelling and pain, has loose bowels, dysentery, oedema due to nephritis, damp and hot dysuria, skin infection abscess, venom.

Flos Hibisci: [source] is the flower of Malvaceae plant Hibiscus syriacus L..[nature and flavor] are sweet, bitter, cool.[return through] lung, spleen, Liver Channel [function cures mainly] clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Main hemorrhoidal hamorrhage rushes down blood, red white dysentery, bleeding hemorrhoids, cough due to lung-heat, hemoptysis, leucorrhea, furuncle carbuncle, scalds.

Herba Zornia Diphyllae: [source] is the herb of leguminous plant Herba Zornia Diphyllae.[nature and flavor] sweet in the mouth, cool in nature.[return through] returns spleen, Liver Channel.[function cures mainly] clearing away heat and expelling pathogen in the exterior, removing pathogenic heat from blood and toxic substance from the body, dehumidifying diuresis.Main anemopyretic cold, pharyngalgia, conjunctival congestion, acute mastitis, sore swollen toxin, venom, jaundice, has loose bowels, dysentery, infantile malnutrition.

Herba monochoriae vaginalis: [source] is the herb of Pontederiaceae plant Herba monochoriae vaginalis.[nature and flavor] are bitter, cool.[function cures mainly] clearing away heat and cooling blood, diuresis is detoxified.The high heat of main flu, lung-heat cough with asthma, pertussis, hemoptysis, spits blood, metrorrhagia, hematuria, pyretic stranguria, dysentery, enteritis, acute appendicitis, erysipelas, and skin ulcer swells, and laryngopharynx swelling and pain, gingival swelling and pain, wind-fire acute conjunctivitis, venom, malicious mushroom is poisoning.

Neoalsomitra integrifoliola (Cogn.) Hucth.: [source] is the tuber of cucurbitaceous plant rod hammer melon.[nature and flavor] bitter in the mouth is puckery, cold in nature.[function cures mainly] heat-clearing and toxic substances removing, pain relieving.Main bacillary dysentery, enteritis, gastritis, pharyngolaryngitis, parotitis, periodontitis, epidemic hemorrhagic conjunctivitis, tonsillitis, high heat, urinary tract infection.

Relieve internal heat grass: the rhizome that [source] is Hemionitidaceae plant Er Yejinmao psilophyton or herb.[nature and flavor] are bitter, cold.[function cures mainly] detoxifies, dampness removing to stop itchin.Main air skin infection infections, eczema, leukorrhagia.

Os Gallus domesticus bavin: [source] removes the root of the two shield wood in south for caprifoliaceae plant.[nature and flavor] bitter in the mouth, property is put down.[function cures mainly] delivers rash, detoxifying and relieving itching.Djumah rash pox poison, damp and hot itching over the body, wears naked wind.

Herba Asparagi Setacei: the tuber that [source] is liliaceous plant Herba Asparagi Setacei or Herb.[nature and flavor] sweet in the mouth, micro-hardship, cold in nature.[function cures mainly] nourishing the lung to arrest cough, reducing heat in the blood and treating stranguria.Main lung-dryness syndrome due to deficiency of YIN, cough, spitting of blood, dribbling urination.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Selaginellae Moellendorfii 20 ~ 30 parts, Herba nepenthis 15 ~ 25 parts, Herba Malvastri Coromandeliani 15 ~ 25 parts, Folium glochidionis puberi 5 ~ 15 parts, Herba Swertiae Mileensis 10 ~ 20 parts, Radix abelmoschi pungentis 35 ~ 45 parts, Herba Abri 5 ~ 15 parts, CUIYUNCAO 35 ~ 45 parts, Radix Bauhiniae Hupehanae 20 ~ 30 parts, Herba Hydrocotylis Nepalensis 10 ~ 20 parts, Ramulus et Folium Mussaendae Pubescentis 10 ~ 20 parts, Flos Hibisci 20 ~ 30 parts, Herba Zornia Diphyllae 15 ~ 25 parts, Herba monochoriae vaginalis 15 ~ 25 parts, Neoalsomitra integrifoliola (Cogn.) Hucth. 5 ~ 15 parts, relieve internal heat grass 10 ~ 20 parts, Os Gallus domesticus bavin 5 ~ 15 parts and Herba Asparagi Setacei 10 ~ 20 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Selaginellae Moellendorfii 20 ~ 25 parts, Herba nepenthis 15 ~ 20 parts, Herba Malvastri Coromandeliani 15 ~ 20 parts, Folium glochidionis puberi 5 ~ 10 parts, Herba Swertiae Mileensis 10 ~ 15 parts, Radix abelmoschi pungentis 35 ~ 40 parts, Herba Abri 5 ~ 10 parts, CUIYUNCAO 35 ~ 40 parts, Radix Bauhiniae Hupehanae 20 ~ 25 parts, Herba Hydrocotylis Nepalensis 10 ~ 15 parts, Ramulus et Folium Mussaendae Pubescentis 10 ~ 15 parts, Flos Hibisci 20 ~ 25 parts, Herba Zornia Diphyllae 15 ~ 20 parts, Herba monochoriae vaginalis 15 ~ 20 parts, Neoalsomitra integrifoliola (Cogn.) Hucth. 5 ~ 10 parts, relieve internal heat grass 10 ~ 15 parts, Os Gallus domesticus bavin 5 ~ 10 parts and Herba Asparagi Setacei 10 ~ 15 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Selaginellae Moellendorfii 23 parts, Herba nepenthis 18 parts, Herba Malvastri Coromandeliani 16 parts, Folium glochidionis puberi 8 parts, Herba Swertiae Mileensis 12 parts, Radix abelmoschi pungentis 37 parts, Herba Abri 6 parts, CUIYUNCAO 39 parts, Radix Bauhiniae Hupehanae 24 parts, Herba Hydrocotylis Nepalensis 13 parts, Ramulus et Folium Mussaendae Pubescentis 14 parts, Flos Hibisci 23 parts, Herba Zornia Diphyllae 19 parts, Herba monochoriae vaginalis 16 parts, Neoalsomitra integrifoliola (Cogn.) Hucth. 7 parts, relieve internal heat grass 12 parts, Os Gallus domesticus bavin 6 parts and Herba Asparagi Setacei 14 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Selaginellae Moellendorfii 25 parts, Herba nepenthis 16 parts, Herba Malvastri Coromandeliani 19 parts, Folium glochidionis puberi 6 parts, Herba Swertiae Mileensis 14 parts, Radix abelmoschi pungentis 40 parts, Herba Abri 8 parts, CUIYUNCAO 36 parts, Radix Bauhiniae Hupehanae 22 parts, Herba Hydrocotylis Nepalensis 11 parts, Ramulus et Folium Mussaendae Pubescentis 12 parts, Flos Hibisci 24 parts, Herba Zornia Diphyllae 17 parts, Herba monochoriae vaginalis 18 parts, Neoalsomitra integrifoliola (Cogn.) Hucth. 8 parts, relieve internal heat grass 15 parts, Os Gallus domesticus bavin 8 parts and Herba Asparagi Setacei 13 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is suppository, and its preparation method comprises the following steps:

The first step: described raw material is soaked 30 minutes to 1 hour, heated and boiled 50 ~ 60 minutes, filter, filtrate is for subsequent use; The second time that adds water filtering residue heats, and boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 20 ~ 30 minutes, filters; Three filtrates be combined, heating is concentrated into pasty state, puts into after 70 DEG C, baking oven is dried and cools, grind to form fine powder.

Second step: to get in semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol and poloxamer poloxamer one or more as substrate; By described substrate heating and melting under DEG C condition of temperature 60 C ~ 70, add first step gained fine powder, stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described fine powder and substrate is 1: 3 ~ 1: 5; Described tampon is the tampon of afterbody with cotton thread.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is washing liquid, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 97%;

Second step: adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 70% ~ 80%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 30 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 97%,

3rd step: add the deionized water relative to mixed powder quality 5 ~ 7 times in the mixed powder that second step obtains, decoct 1 ~ 3 hour, filter, obtain medicine juice.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1 suppository

The ratio of weight and number getting each raw medicinal material in described Chinese medicine also can be preferably: Herba Selaginellae Moellendorfii 230g, Herba nepenthis 180g, Herba Malvastri Coromandeliani 160g, Folium glochidionis puberi 80g, Herba Swertiae Mileensis 120g, Radix abelmoschi pungentis 370g, Herba Abri 60g, CUIYUNCAO 390g, Radix Bauhiniae Hupehanae 240g, Herba Hydrocotylis Nepalensis 130g, Ramulus et Folium Mussaendae Pubescentis 140g, Flos Hibisci 230g, Herba Zornia Diphyllae 190g, Herba monochoriae vaginalis 160g, Neoalsomitra integrifoliola (Cogn.) Hucth. 70g, relieve internal heat careless 120g, Os Gallus domesticus bavin 60g and Herba Asparagi Setacei 140g;

Prepare according to the following steps:

The first step: described raw material is soaked 1 hour, heated and boiled 60 minutes, filter, filtrate is for subsequent use; The second time that adds water filtering residue heats, and boils 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 minutes, filters; Three filtrates be combined, heating is concentrated into pasty state, puts into after 70 DEG C, baking oven is dried and cools, grind to form fine powder.

Second step: get semi-synthetic fatty acid glyceride, Polyethylene Glycol and poloxamer poloxamer, by 1:1:2 mixing, as substrate; By described substrate heating and melting under temperature 70 C condition, add first step gained fine powder, stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described fine powder and substrate is 1: 3; Described tampon is the tampon of afterbody with cotton thread.

Embodiment 2 washing liquid

Get Herba Selaginellae Moellendorfii 250g, Herba nepenthis 160g, Herba Malvastri Coromandeliani 190g, Folium glochidionis puberi 60g, Herba Swertiae Mileensis 140g, Radix abelmoschi pungentis 400g, Herba Abri 80g, CUIYUNCAO 360g, Radix Bauhiniae Hupehanae 220g, Herba Hydrocotylis Nepalensis 110g, Ramulus et Folium Mussaendae Pubescentis 120g, Flos Hibisci 240g, Herba Zornia Diphyllae 170g, Herba monochoriae vaginalis 180g, Neoalsomitra integrifoliola (Cogn.) Hucth. 80g, relieve internal heat careless 150g, Os Gallus domesticus bavin 80g and Herba Asparagi Setacei 130g.

Prepare according to the following steps:

The first step: described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 5 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 97%;

Second step: adding relative to the determining alcohol of the quality 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 36 hours under the condition of 10 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 60 minutes at this, the micron particles of acquisition 2 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 97%,

3rd step: add the deionized water relative to mixed powder quality 5 times in the mixed powder that second step obtains, decoct 2 hours, filter, obtain medicine juice.

Toxicity test:

1, experimental technique: depilatory is evenly coated by guinea pig back spinal column both sides, makes unhairing scope about 40 square centimeters.Clean depilatory returns cage to observe 24 hours, often organize distilled water diluting liquid 0.3,0.5 and 0.8ml that Cavia porcellus is coated with Chinese medicine preparation suppository of the present invention respectively, respectively containing crude drug 110mg, 183mg and 293mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous one week, after experiment terminates, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin do pathological examination.

2, result: above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity are movable, histopathologic examination, the administration group heart, liver, kidney and depilation skin with contrast word more also no significant difference.

Result is pointed out, and Chinese medicine for external application of the present invention, without local irritant effect, also has no general toxicity performance.Show Chinese medicine for external application use safety of the present invention.

Clinical data:

Case selection: whole 122 routine cases are my Out-patient Department patient of in December, 2010 ~ 2013 year November.Patient is divided into treatment group and matched group at random, wherein treatment group 62 people, 15 ~ 50 years old age, average (32.5 ± 3.8) year, nullipara 14 example, multipara 48 example.Matched group 60 people, 16 ~ 52 years old age, average (33.4 ± 4.3) year, nullipara 10 example, multipara 50 example.Two groups in age, the course of disease, symptom, coincident with severity degree of condition and laboratory checking index etc. through statistical analysis there was no significant difference (p>0.05).

BV diagnostic criteria: (1) vaginal secretions homogeneous lean; (2) experiment of vaginal secretions amine is positive; (3) vagina pH>4.5; (4) discover a clue cell.Possess 2 in first 3, isochrone funicular cell accounts for more than 10% namely diagnosable.

Therapeutic Method:

Matched group: after cleaning pudendum before sleeping, put first nitre file bolt 500mg in vagina depths, every day 1 time, being used in conjunction 20 days was 1 course for the treatment of.

Treatment group: after cleaning pudendum before sleeping, put Chinese medicine embodiment 1 suppository of the present invention in vagina depths, every day 1 time, being used in conjunction 20 days was 1 course for the treatment of.

Curative effect judging standard: two group objects all check vaginal secretions after 2 weeks and next clean period after treatment 1 course for the treatment of.Recovery from illness: 4 equal feminine genders in BV diagnostic criteria, clinical symptom disappearance.Effective: only 1 positive in BV diagnostic criteria, clinical symptom disappearance.Effective: only 2 positives in BV diagnostic criteria, clinical symptoms is obviously improved.Invalid: 3 positives in BV diagnostic criteria, clinical symptoms is without improvement.

Therapeutic outcome: in table 1.

A table 1 liang group patient total effects compares

Group	n	Recovery from illness	Effective	Effectively	Invalid	Effectively total
							Treatment group	62	36	18	6	2	60(96.77％)
Matched group	60	22	20	14	12	48(80.00％)

Note: two groups of total effective rates compare p<0.05, and treatment group curative effect is better than matched group.

Two groups of relapse rates compare:

Choose treatment group and matched group case of fully recovering and carry out relapse rate, matched group has 4 people's recurrences, and relapse rate is 18.18% (4/22); Treatment group has 1 people's recurrence, and relapse rate is 2.78% (1/36).Difference has statistical significance (p<0.05), and treatment group relapse rate is lower than matched group.

Concrete case: grandson, women, 35 years old, multipara.On March 25th, 2013 because of pruritus of vagina go to a doctor.Check: vaginal secretions homogeneous lean, vaginal secretions amine tests positive vaginal pH 5.0, and discover a clue cell.Be diagnosed as bacterial vaginitis.Give Chinese medicine embodiment 1 suppository of the present invention every day 1 time, continuous 15 days, recovery from illness, followed up a case by regular visits to and does not recur half a year.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. treat a Chinese medicine for bacterial vaginitis, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Herba Selaginellae Moellendorfii, Herba nepenthis, Herba Malvastri Coromandeliani, Folium glochidionis puberi, Herba Swertiae Mileensis, Radix abelmoschi pungentis, Herba Abri, CUIYUNCAO, Radix Bauhiniae Hupehanae, Herba Hydrocotylis Nepalensis, Ramulus et Folium Mussaendae Pubescentis, Flos Hibisci, Herba Zornia Diphyllae, Herba monochoriae vaginalis, Neoalsomitra integrifoliola (Cogn.) Hucth., relieve internal heat grass, Os Gallus domesticus bavin and Herba Asparagi Setacei.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Selaginellae Moellendorfii 20 ~ 30 parts, Herba nepenthis 15 ~ 25 parts, Herba Malvastri Coromandeliani 15 ~ 25 parts, Folium glochidionis puberi 5 ~ 15 parts, Herba Swertiae Mileensis 10 ~ 20 parts, Radix abelmoschi pungentis 35 ~ 45 parts, Herba Abri 5 ~ 15 parts, CUIYUNCAO 35 ~ 45 parts, Radix Bauhiniae Hupehanae 20 ~ 30 parts, Herba Hydrocotylis Nepalensis 10 ~ 20 parts, Ramulus et Folium Mussaendae Pubescentis 10 ~ 20 parts, Flos Hibisci 20 ~ 30 parts, Herba Zornia Diphyllae 15 ~ 25 parts, Herba monochoriae vaginalis 15 ~ 25 parts, Neoalsomitra integrifoliola (Cogn.) Hucth. 5 ~ 15 parts, relieve internal heat grass 10 ~ 20 parts, Os Gallus domesticus bavin 5 ~ 15 parts and Herba Asparagi Setacei 10 ~ 20 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Selaginellae Moellendorfii 20 ~ 25 parts, Herba nepenthis 15 ~ 20 parts, Herba Malvastri Coromandeliani 15 ~ 20 parts, Folium glochidionis puberi 5 ~ 10 parts, Herba Swertiae Mileensis 10 ~ 15 parts, Radix abelmoschi pungentis 35 ~ 40 parts, Herba Abri 5 ~ 10 parts, CUIYUNCAO 35 ~ 40 parts, Radix Bauhiniae Hupehanae 20 ~ 25 parts, Herba Hydrocotylis Nepalensis 10 ~ 15 parts, Ramulus et Folium Mussaendae Pubescentis 10 ~ 15 parts, Flos Hibisci 20 ~ 25 parts, Herba Zornia Diphyllae 15 ~ 20 parts, Herba monochoriae vaginalis 15 ~ 20 parts, Neoalsomitra integrifoliola (Cogn.) Hucth. 5 ~ 10 parts, relieve internal heat grass 10 ~ 15 parts, Os Gallus domesticus bavin 5 ~ 10 parts and Herba Asparagi Setacei 10 ~ 15 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Selaginellae Moellendorfii 23 parts, Herba nepenthis 18 parts, Herba Malvastri Coromandeliani 16 parts, Folium glochidionis puberi 8 parts, Herba Swertiae Mileensis 12 parts, Radix abelmoschi pungentis 37 parts, Herba Abri 6 parts, CUIYUNCAO 39 parts, Radix Bauhiniae Hupehanae 24 parts, Herba Hydrocotylis Nepalensis 13 parts, Ramulus et Folium Mussaendae Pubescentis 14 parts, Flos Hibisci 23 parts, Herba Zornia Diphyllae 19 parts, Herba monochoriae vaginalis 16 parts, Neoalsomitra integrifoliola (Cogn.) Hucth. 7 parts, relieve internal heat grass 12 parts, Os Gallus domesticus bavin 6 parts and Herba Asparagi Setacei 14 parts.

5. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is suppository, and its preparation method comprises the following steps:

The first step: described raw material is soaked 30 minutes to 1 hour, heated and boiled 50 ~ 60 minutes, filter, filtrate is for subsequent use; The second time that adds water filtering residue heats, and boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 20 ~ 30 minutes, filters; Three filtrates be combined, heating is concentrated into pasty state, puts into after 70 DEG C, baking oven is dried and cools, grind to form fine powder.

Second step: to get in semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol and poloxamer poloxamer one or more as substrate; By described substrate heating and melting under DEG C condition of temperature 60 C ~ 70, add first step gained fine powder, stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described fine powder and substrate is 1: 3 ~ 1: 5; Described tampon is the tampon of afterbody with cotton thread.

6. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is washing liquid, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 97%;

Second step: adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 70% ~ 80%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 30 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 97%,

3rd step: add the deionized water relative to mixed powder quality 5 ~ 7 times in the mixed powder that second step obtains, decoct 1 ~ 3 hour, filter, obtain medicine juice.

7. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is suppository, and its preparation method comprises the following steps:

The first step: described raw material is soaked 30 minutes to 1 hour, heated and boiled 50 ~ 60 minutes, filter, filtrate is for subsequent use; The second time that adds water filtering residue heats, and boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 20 ~ 30 minutes, filters; Three filtrates be combined, heating is concentrated into pasty state, puts into after 70 DEG C, baking oven is dried and cools, grind to form fine powder.

Second step: to get in semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol and poloxamer poloxamer one or more as substrate; By described substrate heating and melting under DEG C condition of temperature 60 C ~ 70, add first step gained fine powder, stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described fine powder and substrate is 1: 3 ~ 1: 5; Described tampon is the tampon of afterbody with cotton thread.

8. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is washing liquid, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 97%;

Second step: adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 70% ~ 80%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 30 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 97%,

3rd step: add the deionized water relative to mixed powder quality 5 ~ 7 times in the mixed powder that second step obtains, decoct 1 ~ 3 hour, filter, obtain medicine juice.