CN105859709A - 二氢嘧啶衍生物的复合物及其在药物中的应用 - Google Patents
二氢嘧啶衍生物的复合物及其在药物中的应用 Download PDFInfo
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- CN105859709A CN105859709A CN201610071071.XA CN201610071071A CN105859709A CN 105859709 A CN105859709 A CN 105859709A CN 201610071071 A CN201610071071 A CN 201610071071A CN 105859709 A CN105859709 A CN 105859709A
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (10)
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CN201510068258X | 2015-02-07 | ||
CN201510068258 | 2015-02-07 |
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CN105859709B CN105859709B (zh) | 2018-12-04 |
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CN201610071071.XA Active CN105859709B (zh) | 2015-02-07 | 2016-02-01 | 二氢嘧啶衍生物的复合物及其在药物中的应用 |
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EP (1) | EP3253751B1 (zh) |
JP (1) | JP2018504414A (zh) |
CN (2) | CN105859708B (zh) |
AU (1) | AU2016214799A1 (zh) |
CA (1) | CA2970838A1 (zh) |
RU (1) | RU2017127611A (zh) |
TW (1) | TW201629054A (zh) |
WO (1) | WO2016124126A1 (zh) |
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JP2019526562A (ja) * | 2016-08-24 | 2019-09-19 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Hbvキャプシドアセンブリ阻害剤とヌクレオシ(チ)ド類似体の併用療法 |
RU2647576C1 (ru) * | 2017-02-28 | 2018-03-16 | Васильевич Иващенко Александр | Циклобутил (S)-2-[[[(R)-2-(6-аминопурин-9-ил)-1-метил-этокси]метил-фенокси-фосфорил]амино]-пропаноаты, способ их получения и применения |
WO2021009509A1 (en) * | 2019-07-15 | 2021-01-21 | Johnson Matthey Public Limited Company | Amorphous umbralisib monotosylate |
CN110615797A (zh) * | 2019-10-11 | 2019-12-27 | 李丽丽 | 用于治疗乙型肝炎的化合物及其用途 |
CN112876493B (zh) * | 2019-11-29 | 2023-05-09 | 广东东阳光药业有限公司 | 含氮三环化合物的盐及其用途 |
JP2023505116A (ja) * | 2019-11-29 | 2023-02-08 | ▲広▼▲東▼▲東▼▲陽▼光▲薬▼▲業▼有限公司 | 三環式含窒素化合物の結晶形及びその用途 |
TW202320764A (zh) * | 2021-08-27 | 2023-06-01 | 日商科研製藥股份有限公司 | 2-(4-乙基苯氧基)-4’-甲氧基-3,3’-聯吡啶的結晶及其製造方法 |
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- 2016-02-01 CA CA2970838A patent/CA2970838A1/en not_active Abandoned
- 2016-02-01 AU AU2016214799A patent/AU2016214799A1/en not_active Abandoned
- 2016-02-01 US US15/539,147 patent/US10098889B2/en active Active
- 2016-02-01 CN CN201610069626.7A patent/CN105859708B/zh active Active
- 2016-02-01 CN CN201610071071.XA patent/CN105859709B/zh active Active
- 2016-02-01 TW TW105103178A patent/TW201629054A/zh unknown
- 2016-02-01 RU RU2017127611A patent/RU2017127611A/ru unknown
- 2016-02-01 JP JP2017538954A patent/JP2018504414A/ja active Pending
- 2016-02-01 WO PCT/CN2016/073105 patent/WO2016124126A1/en active Application Filing
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CN101328168A (zh) * | 2007-06-18 | 2008-12-24 | 张中能 | 一种乙氧碳酰基-取代噻唑二氢嘧啶 |
CN103626752A (zh) * | 2012-08-24 | 2014-03-12 | 广东东阳光药业有限公司 | 二氢嘧啶类化合物及其在药物中的应用 |
CN103664897A (zh) * | 2012-09-01 | 2014-03-26 | 广东东阳光药业有限公司 | 二氢嘧啶类化合物及其在药物中的应用 |
CN103664925A (zh) * | 2012-09-07 | 2014-03-26 | 广东东阳光药业有限公司 | 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用 |
WO2014037480A1 (en) * | 2012-09-10 | 2014-03-13 | F. Hoffmann-La Roche Ag | 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
CN103664899A (zh) * | 2012-09-11 | 2014-03-26 | 广东东阳光药业有限公司 | 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用 |
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JP2018504414A (ja) | 2018-02-15 |
WO2016124126A1 (en) | 2016-08-11 |
EP3253751A4 (en) | 2018-06-20 |
CN105859709B (zh) | 2018-12-04 |
RU2017127611A (ru) | 2019-03-07 |
US20180263991A1 (en) | 2018-09-20 |
CN105859708B (zh) | 2020-01-21 |
EP3253751A1 (en) | 2017-12-13 |
CA2970838A1 (en) | 2016-08-11 |
CN105859708A (zh) | 2016-08-17 |
AU2016214799A1 (en) | 2017-06-15 |
US10098889B2 (en) | 2018-10-16 |
EP3253751B1 (en) | 2020-12-09 |
TW201629054A (zh) | 2016-08-16 |
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