CN105853962A

CN105853962A - Traditional Chinese medicinal preparation for treating leakage of cerebrospinal fluid and preparation method thereof

Info

Publication number: CN105853962A
Application number: CN201610246733.2A
Authority: CN
Inventors: 徐惠
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-04-20
Filing date: 2016-04-20
Publication date: 2016-08-17

Abstract

The invention discloses a traditional Chinese medicinal preparation for treating the leakage of cerebrospinal fluid. The traditional Chinese medicinal preparation for treating the leakage of the cerebrospinal fluid is prepared from semen pharbitidis, semen lepidii, radix lithospermi, rhizoma zingiberis, radix aconiti lateralis praeparata, prince's-feather fruit, semen coicis recens, fried rhizoma atractylodis macrocephalae, poria cocos, grifola, rhizoma alismatis, radix stephaniae tetrandrae, rhizoma imperatae, radix astragali seu hedysari, radix pseudostellariae, herba leonuri, radix cyathulae, radix rhapontici, beautiful sweetgum fruit, thinleaf adina fruit, caulis akebiae, fructus jujubae, rhizoma zingiberis recens and raw liquorice root according to certain proportions by weight. The traditional Chinese medicinal preparation for treating the leakage of the cerebrospinal fluid has the effects of warming the middle warmer for dispelling cold, strengthening the spleen, regulating vital energy, clearing damp, promoting diuresis and clearing away heat and toxic materials, and is obvious in treatment effect.

Description

A kind of Chinese medicine preparation treating cerebrospinal leak and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation treating cerebrospinal leak, the invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

Cerebrospinal leak has torn cerebral dura mater and arachnoidea while being because fracture of skull, so that cerebrospinal fluid is flowed out by fracture seam breach via intranasal application, external auditory meatus or open wound, make cranial cavity and extraneous traffic, form small opening.Often involve caused by tympanum for fracture of middle fossa.Cerebrospinal rhinorrhea is more common in the recessed fracture of front cranium.Often there is bloody fluid to combine film bleed bottom from nasal cavity spilling, eye socket ecchymoma (being commonly called as panda eye), eye after acute patient wound, can the most also injure optic nerve or oculomotorius person with anosmia or go down.The period that retardance cerebrospinal rhinorrhea is often the most different in size after fracture of anterior fossa, during owing to coughing suddenly, firmly causing intracranial pressure suddenly to increase, making meninges holes ftracture, spilling liquid is limpid cerebrospinal fluid.The general leakage increase when patient plays seat, hangs one's head, stops when putting down sleeping, because liquid flows to choana and swallows during dorsal position, or amasss in sphenoid sinus and other Paranasal sinus intracavity, therefore when this kind of patient gets up early morning, discharge is more.

If cerebrospinal leak is treated not in time, can cause a lot of complication, if 1 cerebrospinal fluid is flowed out by open wound, make cranial cavity and extraneous traffic, form small opening, meanwhile, air also can drive in the wrong direction for escaping into and cause pneumoencephalos.If often leading to serious meningitis and encephalitis when 2 cerebrospinal leak are directly from ventricles of the brain penetrating wound.

The most clinically to cerebrospinal leak mainly by non-operative treatment and operative treatment, the overwhelming majority is by non-operative treatment, but if continues also have cerebrospinal leak phenomenon typically can consider operative treatment in 3-4 week more than.Head is raised in non-operative treatment mainly employing, makes cerebral tissue sink at small opening, in order to attaching healing, and puts into the medicine reducing cerebrospinal fluid secretion to reduce oozing out of cerebrospinal fluid.Operation the most usually carries out repairing operation, and the treatment of these treatment meanss is long for the course for the treatment of, and the actual bodily harm to patient is big, and some patient even faces second operation, patient body and go up at heart all to enjoy and decoct, and also brings no small economic pressures to family.

Summary of the invention

It is an object of the invention to provide a kind of Chinese medicine preparation treating cerebrospinal leak, this Chinese medicine preparation has evident in efficacy for cerebrospinal leak, cheap, has no side effect, and is difficult to the feature of recurrence.

It is a further object of the present invention to provide the preparation method of the Chinese medicine preparation of this treatment cerebrospinal leak.

Inventor is in clinical treatment for many years is put into practice, law of development according to this disease, and the combination principle of Chinese medicine, and by substantial amounts of clinical verification, Exploration and conclusion goes out the new formula of a kind of Chinese medicine preparation treating cerebrospinal leak repeatedly, the present invention selects Semen Pharbitidis, Semen Lepidii (Semen Descurainiae), Radix Arnebiae (Radix Lithospermi), Rhizoma Zingiberis, Radix Aconiti Lateralis Preparata, Fructus Polygoni Orientalis, Semen Coicis, Rhizoma Atractylodis Macrocephalae (parched), Poria, Polyporus, Rhizoma Alismatis, Radix Stephaniae Tetrandrae, Rhizoma Imperatae, the Radix Astragali, Radix Pseudostellariae, Herba Leonuri, Radix Cyathulae, Radix Rhapontici, Fructus Liquidambaris, Fructus Adinae, Caulis Akebiae, Fructus Jujubae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae is combined, these drug regimens make each efficacy of drugs produce synergism, it is allowed to that there is warming spleen and stomach for dispelling cold, spleen invigorating is regulated the flow of vital energy, promoting diuresis to eliminate damp pathogen, effect of heat-clearing and toxic substances removing, it is thus possible to the most effectively treat cerebrospinal leak.

The effect of Chinese medicine of the present invention:

Wherein:

Semen Pharbitidis: for convolvulaceous plant pharbitis nilChoisy Pharbitis nil (L.) Choisy Or the dry mature seed of Pharbitis purpurea Pharbitis purpurea (L.) Voigt, surface grey black, become Semen Pharbitidis.Nature and flavor: bitter, cold；Poisonous.Return lung, kidney, large intestine channel.Effect: removing water retention by purgation relieving constipation, expectorant washs drink, and parasite killing is attacked long-pending.For edema distension, constipation and anuresis, phlegm retention gathers, and QI rising in reverse order is breathed with cough, abdominal pain due to worm stagnation, ascarid, taeniasis.The stagnation of QI, cough with dyspnea dyspnea with fullness of the chest, the normal and fit applications such as Semen Lepidii (Semen Descurainiae), Semen Armeniacae Amarum is stopped up for expectorant.

Semen Lepidii (Semen Descurainiae): for crucifer Lepidium sativum L. Lepidium apetalum Willd. or descurainia sophia (l.) webb ex prantl Descurainia The dry mature seed of sophia (L.) Webb ex prantl.Nature and flavor: pungent, bitter, Great Cold.Return lung, bladder warp.Effect: eliminating pathogen from the lung for relieving asthma, line water detumescence.Stop up lung, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium for sputum, must not put down sleeping, chest and abdomen edema, dysuria；Pulmonary heart disease edema." Bencao Jingshu ": Semen Lepidii, for the positive medicine of meridian of Hand-TAI YIN, therefore Zhong Jing eliminating the pathogens from the lung soup with it, bright, the meridian of Foot-TAI YANG of sun of also starting with.The lung belonging to metal, main fur, bladder belongs to water, hides body fluid, and obstruction of lung-QI then bladder is with here, and the upper orifices of example closes that then lower orifices are obstructed, and lower orifices are obstructed, then water is wet overflows for dyspnea with fullness of the chest, for swelling, for accumulation, all diease occurrences.Pungent energy dissipates, and hardship can be let out, and Great Cold, heavy the moon can descending be relieved oedema or abdominal distension through diuresis or purgation, therefore can treat " herbal classic " and be led all diseases.

Radix Arnebiae (Radix Lithospermi): for the root of comfrey Radix Arnebiae (Radix Lithospermi) (gromwell root) (Lithosper-mum erythorhizon sieb. et zucc.) and lithospermum euchromum Royle (Radix Arnebiae) [Arnebia euchroma(Royle) Johnst.].Nature and flavor: cold, sweet, salty.Gui Jing: GUIXIN, Liver Channel.Function: removing heat from blood, invigorates blood circulation, rash of detoxifying.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood, for measles, calentura skin eruption, eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, constipation with heat retention.

Rhizoma Zingiberis: for the dry rhizome of zingiber Zingiber officinale Rosc..Nature and flavor: pungent, hot.Return spleen, stomach, the heart, lung meridian.Effect: warming spleen and stomach for dispelling cold, recuperating depleted YANG promotes blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.For coldness and pain in the epigastrium, vomiting is had loose bowels, cold extremities faint pulse, and phlegm retention is breathed with cough.Rhizoma Zingiberis external curing wound pyogenic infection.This product hot dry strong, main enter taste warp, be longer than warm middle burnt spleen sun and cold expelling, therefore all middle burnt cold syndrome, the excess-cold syndrome no matter invaded in exogenous cold, or the deficiency-cold syndrome of YANG QI deficiency, be key medicine, often join Rhizoma Alpiniae Officinarum treatment coldness and pain in the epigastrium, have loose bowels.

Radix Aconiti Lateralis Preparata: for the dry tuber of aroid Herba Typhonii gigantei Typhonium giganteum Engl..Nature and flavor: pungent, warm, poisonous.Return stomach, Liver Channel.Effect: dispel the wind expectorant, arresting convulsion is jerked, detoxicating and resolving stagnation of pathogens pain relieving.Stopping up for middle wind-phlegm, facial hemiparalysis, language is puckery stuttering, and syncope due to accumulation of phlegm is had a headache, migraine and general headache, sore throat pharyngalgia, tetanus；External treatment scrofula sucutaneous nodule, venom, tetanus, carbuncle.

Fructus Polygoni Orientalis: for polygonaceae plant smartweed Polygonum The dry mature fruit of orientale L..Nature and flavor: salty, cold.Return liver, stomach, spleen three warp.Function: repercussive removing mass, invigorating spleen to remove dampness.Controlling flank disease to amass, dropsy, have a stomach-ache, lack of appetite abdominal distention, acute catarrhal conjunctivitis, skin ulcer swells, scrofula.

Semen Coicis: for the dry mature kernal of grass Semen Coicis Coix lacryma-jobi L. var. ma-yuen (Roman.) Stapf.Nature and flavor: sweet, light, cool.Return spleen, stomach, lung meridian.Effect: spleen invigorating eliminating dampness by diuresis, eliminating impediment pain relieving, clearing away heat and discharging pus.For edema, tinea pedis, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, acute appendicitis；Verruca plana.For the disease of retention of damp-heat in the interior, to oliguria with reddish urine, use can be equal to Talcum, Medulla Tetrapanacis；To hygropyrexia pathogenic factor at edema caused by disorder of QI, the inclined victor of damp, use can be equal to Semen Armeniacae Amarum, KOUREN, Folium Bambusae, Caulis Akebiae.This product has again the merit of spleen invigorating, and in order to control edema due to deficiency of the spleen, tinea pedis swells and ache, and compatibility Poria, white, Fructus Chaenomelis, Fructus Evodiae equivalent are used.For insufficiency of the spleen have wet have loose bowels, leukorrhagia, can be with compatibilities such as white, Poria.The arthralgia pain contracture caused for humidity hysteresis flesh tendon, often and Ramulus Cinnamomi, the fit applications such as grey.Control lung abscess chest pain, coughing up vomiting pus expectorant can be with compatibilities such as fresh Rhizoma Phragmitis, Semen Benincasae, Semen Persicae, Herba Houttuyniae.

Rhizoma Atractylodis Macrocephalae (parched): for the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Rhizoma Atractylodis Macrocephalae (parched), for be sprinkled in hot pot by processed with honey wheat bran, adds Rhizoma Atractylodis Macrocephalae sheet in time smoldering, and fries to coke yellow, effusion burnt odor gas, takes out, and sieve removes processed with honey wheat bran.Every 100kg Rhizoma Atractylodis Macrocephalae sheet, with processed with honey wheat bran 10kg.Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, the Rhizoma Atractylodis Macrocephalae can air making-up and spleen enlivening, again can dampness diuretic, for the key medicine of the spleen strengthening and damp drying.In the sweet temperature compensation of the Rhizoma Atractylodis Macrocephalae, can air making-up and spleen enlivening, also can strengthening superficial resistance to stop perspiration, and the Radix Astragali, Radix Pseudostellariae compatibility, play the merit of spleen reinforcing lung altogether.Rule together asthenia, the weak person of overstrain.Rhizoma Atractylodis Macrocephalae antibacterial action is obvious: infusion in vitro has inhibitory action to acrothesium floccosum, star nocardia.Decoct also has inhibitory action to meningococcus.

Poria: for the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Sweet the providing additional supplies of this product is oozed, and not only mends but also sharp, and effect is gentle, and property is flat and partially without cold and heat, for the key medicine of promoting diuresis to eliminate damp pathogen.When treating the edema of the wet expert of water, often join Rhizoma Alismatis, Polyporus.Poria decoct has obvious sedation." modality ": " curing mainly and throb with fear and meat muscle is cautious, it is irritated that dizziness is controlled on side.” This product is tranquilizing mind by heart-spleen boosting.It is used for deficiency of both the heart and spleen, the irritability of insufficiency of vital energy and blood.

Polyporus: for the dry sclerotia of On Polyporaceae Polyporus Polyporus umbellatus (Pers.) Fries.Nature and flavor: sweet, light, flat.Return kidney, bladder warp.Effect: promoting diuresis to eliminate damp pathogen.Polyporus and Poria compatibility, Polyporus specializes in promoting diuresis to eliminate damp pathogen, and diuretic effect is strong in Poria, and Poria is not only mended but also sharp, and holding concurrently can spleen invigorating mind calming.

Rhizoma Alismatis: for the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..Nature and flavor: sweet, cold.Return kidney, bladder warp.Effect: diuresis, clearing away damp-heat.Edema, dysuria for retention of water-damp in the body.Rhizoma Alismatis and the same use of the Rhizoma Atractylodis Macrocephalae, can be used for the dizziness caused by damp-phlegm drink of harnessing the river.This product enters kidney, bladder warp, kind clear damp-heat in lower-JIAO cold in nature.In addition to staphylococcus aureus, Diplococcus pneumoniae, tubercule bacillus has inhibitory action.

Radix Stephaniae Tetrandrae: for the dry root of menispermaceous plants Radix stephaniae tetrandrae Stephania tetrandra S. Moore.Nature and flavor: bitter, cold.Return bladder, lung meridian.Effect: inducing diuresis to remove edema, wind-expelling pain-stopping.For edema tinea pedis, dysuria, eczema sore, rheumatic arthralgia；Hypertension.For rheumatic arthralgia, many compatibilities Semen Coicis, Talcum, bite the product of the removing damp-heats such as sand.To same use of medicine such as arthralgia due to cold-dampnes, the Cortex Cinnamomi of palpus antalgic, Radix Aconiti Lateralis Preparatas.For the disease such as edema, dysuria, can be with the same use of compatibility such as Semen zanthoxyli, Semen Lepidii (Semen Descurainiae), Fructus Jujubae, if belonging to deficiency syndrome, often with Radix Astragali, Poria, the compatibility such as in vain.

Rhizoma Imperatae: for the rhizome of grass perennial herb Herba Imperatae Imperata cylindrica.Nature and flavor: sweet, cold.Return lung, stomach, bladder warp.Effect: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria；Acute nephritis edema." Bencao Jingshu " is recorded: impairment caused by overstrain void is won, must interior-heat, Rhizoma Imperatae sweet can spleen reinforcing, sweet, do not violate stomach though cold.Gan Hanneng removes interior-heat, therefore main impairment caused by overstrain void is won.Strengthening the spleen so invigorating middle warmer, heat extraction so QI invigorating, sweet can benefit blood, the heat in blood then stasis of blood, the stasis of blood is then closed, and closes then cold and heat and makees, cold and cool blood, sweet benefit blood, heat go then blood and, and then stagnation resolvation and close logical, general rule cold and heat are from the most also.Dysuria, due to interior-heat also, pyrolysis the most just diarrhea.Pouring person, caused by blood system deficiency-heat also, removing heat from blood benefit blood, then drench spontaneous recovery, and the exopathogenic heat of the intestines and stomach explained by oneself, body fluid raw and thirsty the most only.Blood stored in the liver and main muscle, cool liver of enriching blood, then muscle is hard.Heat in blood then collapses, removing heat from blood and blood, then collapse spontaneous recovery.The most absurd row of heat in blood, overflows upper orifices for telling, for coughing up, for epistaxis, bleeding from the gum, removing heat from blood and blood, the most all cards oneself remove.Strengthening the spleen invigorating middle warmer, diuresis, therefore swollen jaundice of also harnessing the river, and hold concurrently reason typhoid fever hiccup also.

The Radix Astragali: for leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus The dry root of membranaceus (Fisch.) Bge..Nature and flavor: sweet, tepor.Return lung, spleen, liver, kidney channel.Effect: tonifying Qi and lifting yang, consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, torr skin ulcer evacuation of pus, regulating fluid apssage.This product all has inhibitory action to dysentery bacterium, anthrax bacillus, α-hemolytic streptococcus, beta hemolytic streptococcus, diphtheria corynebacterium, bacillus pseudodiphthericus, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus citreus, bacillus subtilis etc. in vitro.Invigorating the spleen and replenishing QI is good at by the Radix Astragali, for the key medicine of tonifying Qi and lifting yang, and QI invigorating diuresis, with detumescence.

Radix Pseudostellariae: belong to the dry root of (Pseudostellaria) plant Radix Pseudostellariae for Caryophyllaceae Radix Pseudostellariae.Nature and flavor: sweet, micro-hardship, tepor.Return lung, spleen channel.Effect: mend strengthening spleen and lung, supplementing QI for promoting the production of body fluid.Control cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus, palpitation with a distress feeling, edema, quench one's thirst, metal fatigue.Tcm clinical practice uses widely.The patient typically have the deficiency of both QI and YIN symptoms such as xerostomia, agitation, cardiopalmus, insomnia, weak, lack of appetite, feverish sensation in the palms and soles all can use.The Radix Pseudostellariae property of medicine is very steady, and applicable chronic patient is taken the most in a large number, and for those bodies are empty, to be unable to bear nourishing medicine high benefit people be optimal selection, and will not cause elevation of the blood pressure, the symptom such as get angry.

Herba Leonuri: or the herb of two year raw herbaceous plant Herba Leonuri Leonurus heterophyllus Sweet. annual for Labiatae.Nature and flavor: bitter, pungent, are slightly cold.Return liver, pericardium channel.Effect: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria；Acute nephritis edema.This product hardship lets out pungent dissipating, and master enters blood system, is good at blood circulation promoting and blood stasis dispelling regulating menstruation, flaccidity gynecological multiparity key medicine.

Radix Cyathulae: for the dry root of amaranthaceous plant Radix Cyathulae Cyathula officinalis Kuan.Nature and flavor: hardship sweet, micro-, flat.Return liver, kidney channel.Effect: eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.For amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.

Radix Rhapontici: for the dry root of feverfew centaurea monanthos Georgi Rhaponticum uniflorum (L.) DC..Nature and flavor: bitter, cold.Return stomach warp.Effect: heat-clearing and toxic substances removing, eliminating carbuncle, stimulating milk secretion, relaxing muscles and tendons is promoted blood circulation.Swell and ache for acute mastitis, carbuncle carbuncle on the back, scrofula sore, galactostasis, arthralgia chiefly caused by damp pathogen contracture.For carbuncle sore from the beginning of red and swollen heat pain, the normal and fit applications such as Fructus Forsythiae, Radix Et Rhizoma Rhei；Carbuncle person to be become for breast congestion and swelling pain, often and the fit applications such as Fructus Trichosanthis, Herba Taraxaci, Bulbus Fritillariae Uninbracteatae.

Fructus Liquidambaris: for the drying and ripening infructescence of Hamamelidaceae Plants Chinese sweet gum Liquidambar formosana Hance.Nature and flavor: bitter are flat.Return liver, kidney channel.Effect: dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast." Chinese medicinal herbal ": stimulate the menstrual flow diuretic, dehumidifying pyretic arthralgia pain.Controlling menoxenia, all over the body arthralgia pain, dysuria, edema distension etc. is demonstrate,proved.

Fructus Adinae: for Rubiaceae avens Fructus Adinae Adina rubella Hance, stem and leaf or flowers and fruits sequence.Nature and flavor: bitter, puckery are cool.Effect: heat-clearing and toxic substances removing, eliminating stasis to stop pain.Pharmacological action: water logging agent and decoct tube dilution method, 1:100 is to golden yellow staphylococcus, Hemolytic streptococcus and trichomonas vaginitis, and 1:10 all has inhibitory action to various dysentery bacteriums etc..Separate from Fructus Adinae and raise 2 active component, for its ellagic acid compounds of first, staphylococcus aureus and bacillus pyocyaneus are had inhibitory action.

Caulis Akebiae: for the rattan of Aristolochiaceae liana northeast Fructus Aristolochiae.Nature and flavor: bitter, cold, poisonous.GUIXIN, small intestinal, bladder warp.Effect: pure and fresh diuresis, stimulating milk secretion of stimulating the menstrual flow.This product can go up clearing away heart-fire, lower diuresis, makes damp and hot heresy descending from urine discharge.Caulis Akebiae property is apt to tonneau, stimulating milk secretion of can stimulating the menstrual flow, again can easing joint movement blood vessels, with controlling damp and hot arthralgia pain, many with Semen Coicis with use.

Fructus Jujubae: for the dry mature fruit of Rhamnaceae jujube Fructus Jujubae Ziziphus jujuba Mill. var. inermis (Bunge) Rehd..Nature and flavor: sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.For tracheitis, enteritis, dysentery, metrorrhagia；Traumatic hemorrhage is controlled in external." herbal classic ": main trusted subordinate's pathogen, regulating the spleen and stomach is supported spleen, is helped 12 warps.Flat gastric qi, logical nine orifices, mend few gas, few body fluid, not enough in body, frightened, heaviness of limbs, and hundred medicines." book on Chinese herbal medicine is the newest ": invigorating the spleen and replenishing QI, nourishing kidney warming the stomach, control the deficiency of YIN.

Rhizoma Zingiberis Recens: for the fresh rhizome of zingiber Zingiber officinale Rosc..Nature and flavor: pungent, tepor.Return lung, spleen, stomach warp.Effect: relieving the exterior syndrome by diaphoresis, warming middle-JIAO to arrest vomiting, warming the lung to relieve cough, solving toxin of fish and crab, solve poison of drug.Especially for fish Eriocheir sinensis poison, the drug intoxication such as the Rhizoma Pinelliae, Rhizoma Arisaematis has Detoxication.Rhizoma Zingiberis Recens may act on sympathetic nerve and vagal system, has suppression stomach function and the effect of the most excited pipe smooth muscle, and Rhizoma Zingiberis Recens has inhibitory action to central nervous system.

Radix Glycyrrhizae: for glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or the dry root and rhizome of Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Radix Glycyrrhizae Preparata is that processed goods baked by the honey of Radix Glycyrrhizae.Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mending five kinds of strain and seven kinds of impairment, all are deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, benefit intensive culture gas, strengthening bone and muscle, solve cold and hot.

The square solution of the present invention is: in Fang, drink, Semen Lepidii (Semen Descurainiae) eliminating pathogen from the lung for relieving asthma, line water detumescence are washed in Semen Pharbitidis expectorant, Radix Arnebiae (Radix Lithospermi) removing heat from blood and promoting blood circulation, Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG promote blood circulation, and Radix Aconiti Lateralis Preparata dispels the wind and determines convulsion, the above five tastes are monarch drug altogether, can promote the healing of the outer wound of patient, reduce cerebral dura mater and arachnoid again rupture, Rhizoma Zingiberis, Radix Arnebiae (Radix Lithospermi) etc. fundamentally nurse one's health the health of patient, internal organs can be got into smooth normally, QI and blood essence body fluid is sufficient, could accelerate the recovery of patient, releases the slight illness of patient.Fructus Polygoni Orientalis, Semen Coicis invigorating spleen to remove dampness, Rhizoma Atractylodis Macrocephalae (parched) spleen invigorating is regulated the flow of vital energy, Poria, Polyporus, Rhizoma Alismatis promoting diuresis to eliminate damp pathogen, Radix Stephaniae Tetrandrae inducing diuresis to remove edema, wind-expelling pain-stopping, Rhizoma Imperatae cooling blood for hemostasis, above eight tastes are ministerial drug altogether, ministerial drug is started with in focus, and promoting diuresis to eliminate damp pathogen, spleen invigorating are regulated the flow of vital energy, the spleen being the foundation of acquired constitution, source of generating QI and blood, The spleen has the function to transport and transform nutrients, blood of uniting, and plays an important role in human liquid's metabolic process, and deficiency of spleen-QI then visceroptosis, body fluid is not solid, and overflows in external, and invigorating the spleen and benefiting QI then symptom is from disappearing, ministerial drug is started with through row from focus, promotes the recovery from illness of patient.Radix Astragali tonifying Qi and lifting yang, consolidating superficial resistance arresting sweating, Radix Pseudostellariae supplementing QI for promoting the production of body fluid, Herba Leonuri promoting blood flow to regulate menstruation, Radix Cyathulae easing joint movement, Radix Rhapontici, Fructus Adinae heat-clearing and toxic substances removing, Fructus Liquidambaris expelling wind and activating blood circulation, Caulis Akebiae clears away heart-fire diuresis, Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, Rhizoma Zingiberis Recens warming the meridian and promoting blood circulation, the most several tastes are adjuvant drug altogether, Radix Rhapontici, Fructus Adinae etc. have heat-clearing and toxic substances removing, the effect of the army's of rectifying antiinflammatory more, can treat the situation because of the meningitis caused by cerebrospinal leak and encephalitis, and the scholar such as the Radix Astragali, Radix Pseudostellariae, Radix Cyathulae, Fructus Jujubae supports the health of patient, strengthen the body constitution of patient, accelerate the improvement of the state of an illness.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes the most auxiliary, have warming spleen and stomach for dispelling cold, spleen invigorating is regulated the flow of vital energy, effect of promoting diuresis to eliminate damp pathogen, heat-clearing and toxic substances removing, it is possible to effectively treat cerebrospinal leak.

nullMedicine material consumption of the present invention is groped to sum up to draw through inventor in a large number，Each raw material dosage is for all having a preferable curative effect in following weight parts scope: Semen Pharbitidis 4-14g、Semen Lepidii (Semen Descurainiae) 4-14g、Radix Arnebiae (Radix Lithospermi) 10-20g、Rhizoma Zingiberis 10-20g、Radix Aconiti Lateralis Preparata 7-17g、Fructus Polygoni Orientalis 10-20g、Semen Coicis 19-29g、Rhizoma Atractylodis Macrocephalae (parched) 25-35g、Poria 19-29g、Polyporus 19-29g、Rhizoma Alismatis 15-25g、Radix Stephaniae Tetrandrae 7-17g、Rhizoma Imperatae 25-35g、Radix Astragali 25-35g、Radix Pseudostellariae 7-17g、Herba Leonuri 15-25g、Radix Cyathulae 10-20g、Radix Rhapontici 10-20g、Fructus Liquidambaris 10-20g、Fructus Adinae 10-20g、Caulis Akebiae 4-14g、Fructus Jujubae 5-15g、Rhizoma Zingiberis Recens 4-14g、Radix Glycyrrhizae 1-5g.

Wherein it is preferably: Semen Pharbitidis 9g, Semen Lepidii (Semen Descurainiae) 9g, Radix Arnebiae (Radix Lithospermi) 15g, Rhizoma Zingiberis 15g, Radix Aconiti Lateralis Preparata 12g, Fructus Polygoni Orientalis 15g, Semen Coicis 24g, Rhizoma Atractylodis Macrocephalae (parched) 30g, Poria 24g, Polyporus 24g, Rhizoma Alismatis 20g, Radix Stephaniae Tetrandrae 12g, Rhizoma Imperatae 30g, Radix Astragali 30g, Radix Pseudostellariae 12g, Herba Leonuri 20g, Radix Cyathulae 15g, Radix Rhapontici 15g, Fructus Liquidambaris 15g, Fructus Adinae 15g, Caulis Akebiae 9g, Fructus Jujubae 10g, Rhizoma Zingiberis Recens 9g, Radix Glycyrrhizae 3g.

Medicine of the present invention can use the conventional method of Chinese medicine preparation to be prepared as any conventional oral preparations, such as pill, powder, tablet, oral liquid etc..These crude drug such as can be ground into powder mix homogeneously make powder and take after mixing it with water；Decocting can be used, through filtering to get filtrate, add preservative and make oral liquid；Can also directly take decoction if desired.

Currently preferred preparation method is decoction, and its preparation method is as follows:

Step one: by weight proportion of the present invention, is first placed in cold water immersion 15-25 minute by Semen Pharbitidis, Semen Lepidii (Semen Descurainiae), Fructus Polygoni Orientalis, Semen Coicis, Fructus Liquidambaris, Fructus Jujubae, standby；

Step 2: by weight proportion of the present invention, weigh Radix Arnebiae (Radix Lithospermi), Rhizoma Zingiberis, Rhizoma Atractylodis Macrocephalae (parched), Radix Stephaniae Tetrandrae, Rhizoma Imperatae, the Radix Astragali, Radix Pseudostellariae, Radix Cyathulae, Radix Rhapontici, Rhizoma Zingiberis Recens is put in marmite, add remaining cold water after step one is soaked, smeared medical material 3-5 centimetre, first boil with high heat, 30-40 minute is decocted again with slow fire, filter, obtain filtrate, the water of 2-3 centimetre is added in residue medicinal residues, it is subsequently adding Radix Aconiti Lateralis Preparata, Rhizoma Alismatis, Poria, Polyporus, Herba Leonuri, Fructus Adinae, Caulis Akebiae, medicated bag in Radix Glycyrrhizae and step one continues to decoct 20 minutes, filter, obtain filtrate, merge twice filtrate, waste, standby；

Step 3: the medicinal liquid in step 2 is mixed uniformly, both the Chinese medicine decoction for the treatment of cerebrospinal leak of the present invention.

Medicine of the present invention has warming spleen and stomach for dispelling cold, spleen invigorating is regulated the flow of vital energy, effect of promoting diuresis to eliminate damp pathogen, heat-clearing and toxic substances removing, and treat evident in efficacy, cheap, having no side effect, be difficult to recurrence, the mode that this Chinese medicine preparation uses treats cerebrospinal leak and its complication, alleviate the slight illness of patient, according to clinical 100 example patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 80%, two the course for the treatment of total effective rate 93%.

Detailed description of the invention

Embodiment one, Semen Pharbitidis 4g, Semen Lepidii (Semen Descurainiae) 4g, Radix Arnebiae (Radix Lithospermi) 10g, Rhizoma Zingiberis 10g, Radix Aconiti Lateralis Preparata 7g, Fructus Polygoni Orientalis 10g, Semen Coicis 19g, Rhizoma Atractylodis Macrocephalae (parched) 25g, Poria 19g, Polyporus 19g, Rhizoma Alismatis 15g, Radix Stephaniae Tetrandrae 7g, Rhizoma Imperatae 25g, Radix Astragali 25g, Radix Pseudostellariae 7g, Herba Leonuri 15g, Radix Cyathulae 10g, Radix Rhapontici 10g, Fructus Liquidambaris 10g, Fructus Adinae 10g, Caulis Akebiae 4g, Fructus Jujubae 5g, Rhizoma Zingiberis Recens 4g, Radix Glycyrrhizae 1g.

Embodiment two, Semen Pharbitidis 9g, Semen Lepidii (Semen Descurainiae) 9g, Radix Arnebiae (Radix Lithospermi) 15g, Rhizoma Zingiberis 15g, Radix Aconiti Lateralis Preparata 12g, Fructus Polygoni Orientalis 15g, Semen Coicis 24g, Rhizoma Atractylodis Macrocephalae (parched) 30g, Poria 24g, Polyporus 24g, Rhizoma Alismatis 20g, Radix Stephaniae Tetrandrae 12g, Rhizoma Imperatae 30g, Radix Astragali 30g, Radix Pseudostellariae 12g, Herba Leonuri 20g, Radix Cyathulae 15g, Radix Rhapontici 15g, Fructus Liquidambaris 15g, Fructus Adinae 15g, Caulis Akebiae 9g, Fructus Jujubae 10g, Rhizoma Zingiberis Recens 9g, Radix Glycyrrhizae 3g.

Embodiment three, Semen Pharbitidis 14g, Semen Lepidii (Semen Descurainiae) 14g, Radix Arnebiae (Radix Lithospermi) 20g, Rhizoma Zingiberis 20g, Radix Aconiti Lateralis Preparata 17g, Fructus Polygoni Orientalis 20g, Semen Coicis 29g, Rhizoma Atractylodis Macrocephalae (parched) 35g, Poria 29g, Polyporus 29g, Rhizoma Alismatis 25g, Radix Stephaniae Tetrandrae 17g, Rhizoma Imperatae 35g, Radix Astragali 35g, Radix Pseudostellariae 17g, Herba Leonuri 25g, Radix Cyathulae 20g, Radix Rhapontici 20g, Fructus Liquidambaris 20g, Fructus Adinae 20g, Caulis Akebiae 14g, Fructus Jujubae 15g, Rhizoma Zingiberis Recens 14g, Radix Glycyrrhizae 5g.

Patient is presented herein below and uses the clinical statistics data of medicine of the present invention:

One, physical data

Accept out-patient 100 example, wherein male 48 example, women 52 example, M-F 1:1.08, age 40-72 year for medical treatment.

Two, Therapeutic Method:

According to Medications Example two of the present invention, and the decoction that preferably preparation method is made, sooner or later service once, one day twice, 10 days be a course for the treatment of.

Three, efficacy assessment standard:

1, cure: cerebrospinal leak phenomenon disappears, the clinical headache occurred, feel sick and wait transference cure；

2, effective: cerebrospinal leak substantially alleviates, there is slight paraesthesia, clinical symptoms is eased；

3, invalid: cerebrospinal leak is without improving.

Four, therapeutic outcome statistics

Wherein: total effective rate=cure rate+improvement rate

Being shown by the statistics of therapeutic outcome, Chinese medicine of the present invention has good clinical effectiveness in treatment cerebrospinal leak, can be effectively improved the cure rate for the treatment of, is worth in clinical practice promoting.

Model case and curative effect:

Case one, patient poplar, female, 53 years old, patient is slight fracture of skull because traffic accident causes, hospital is gone to give treatment to, patient's wound is cured substantially, leave hospital, but the phenomenon of cerebrospinal leak occurs, due to financial difficulties in family, patient is unwilling to be treated surgically, just the most medical in here, use made preparation in the embodiment of the present invention two, and selected preparation method, take after decoction treats a period of time, the state of an illness is taken a turn for the better, the phenomenon of leakage significantly reduces, continue to take decoction to two courses for the treatment of, thoroughly cure, examination in hospital cerebrospinal leak phenomenon disappears, through following up a case by regular visits to of half a year, do not recur.Cure.

Case two, grandson patient, man, 60 years old, there is the phenomenon of cerebrospinal leak because of wound in patient, goes to hospital to take corresponding antibacterials in case infecting, and takes other treatment measure, poor effect, just the most medical in here, use made preparation in the embodiment of the present invention two, and selected preparation method, after taking a course for the treatment of, the phenomenon of cerebrospinal leak is controlled, but still has cerebrospinal fluid when of firmly and ooze out, and with the phenomenon of dizziness headache, cure by the thorough treatment of two courses for the treatment of, through following up a case by regular visits to of half a year, do not recur, cure.

Claims

null1. the Chinese medicine preparation treating cerebrospinal leak，It is characterized in that，This Chinese medicine preparation is made up of the medicine of following weight portion: Semen Pharbitidis 4-14g、Semen Lepidii (Semen Descurainiae) 4-14g、Radix Arnebiae (Radix Lithospermi) 10-20g、Rhizoma Zingiberis 10-20g、Radix Aconiti Lateralis Preparata 7-17g、Fructus Polygoni Orientalis 10-20g、Semen Coicis 19-29g、Rhizoma Atractylodis Macrocephalae (parched) 25-35g、Poria 19-29g、Polyporus 19-29g、Rhizoma Alismatis 15-25g、Radix Stephaniae Tetrandrae 7-17g、Rhizoma Imperatae 25-35g、Radix Astragali 25-35g、Radix Pseudostellariae 7-17g、Herba Leonuri 15-25g、Radix Cyathulae 10-20g、Radix Rhapontici 10-20g、Fructus Liquidambaris 10-20g、Fructus Adinae 10-20g、Caulis Akebiae 4-14g、Fructus Jujubae 5-15g、Rhizoma Zingiberis Recens 4-14g、Radix Glycyrrhizae 1-5g.
The Chinese medicine preparation for the treatment of cerebrospinal leak the most according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Semen Pharbitidis 9g, Semen Lepidii (Semen Descurainiae) 9g, Radix Arnebiae (Radix Lithospermi) 15g, Rhizoma Zingiberis 15g, Radix Aconiti Lateralis Preparata 12g, Fructus Polygoni Orientalis 15g, Semen Coicis 24g, Rhizoma Atractylodis Macrocephalae (parched) 30g, Poria 24g, Polyporus 24g, Rhizoma Alismatis 20g, Radix Stephaniae Tetrandrae 12g, Rhizoma Imperatae 30g, Radix Astragali 30g, Radix Pseudostellariae 12g, Herba Leonuri 20g, Radix Cyathulae 15g, Radix Rhapontici 15g, Fructus Liquidambaris 15g, Fructus Adinae 15g, Caulis Akebiae 9g, Fructus Jujubae 10g, Rhizoma Zingiberis Recens 9g, Radix Glycyrrhizae 3g.
The Chinese medicine preparation for the treatment of cerebrospinal leak the most according to claim 1 and 2, it is characterised in that: described Chinese medicine preparation is decoction.
4. the preparation method of the Chinese medicine preparation treating cerebrospinal leak, it is characterised in that preparation method is as follows:

Step one: by weight proportion of the present invention, is first placed in cold water immersion 15-25 minute by Semen Pharbitidis, Semen Lepidii (Semen Descurainiae), Fructus Polygoni Orientalis, Semen Coicis, Fructus Liquidambaris, Fructus Jujubae, standby；

Step 2: by weight proportion of the present invention, weigh Radix Arnebiae (Radix Lithospermi), Rhizoma Zingiberis, Rhizoma Atractylodis Macrocephalae (parched), Radix Stephaniae Tetrandrae, Rhizoma Imperatae, the Radix Astragali, Radix Pseudostellariae, Radix Cyathulae, Radix Rhapontici, Rhizoma Zingiberis Recens is put in marmite, add remaining cold water after step one is soaked, smeared medical material 3-5 centimetre, first boil with high heat, 30-40 minute is decocted again with slow fire, filter, obtain filtrate, the water of 2-3 centimetre is added in residue medicinal residues, it is subsequently adding Radix Aconiti Lateralis Preparata, Rhizoma Alismatis, Poria, Polyporus, Herba Leonuri, Fructus Adinae, Caulis Akebiae, medicated bag in Radix Glycyrrhizae and step one continues to decoct 20 minutes, filter, obtain filtrate, merge twice filtrate, waste, standby；

Step 3: the medicinal liquid in step 2 is mixed uniformly, both the Chinese medicine decoction for the treatment of cerebrospinal leak of the present invention.