CN105853598A - Application of Weichang Anwan in combination with artemether in treating gastrointestinal form of malaria - Google Patents
Application of Weichang Anwan in combination with artemether in treating gastrointestinal form of malaria Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention discloses the application of Weichang Anwan in combination with artemether in treating the gastrointestinal form of malaria. According to improved gastrointestinal symptoms, the Weichang Anwan shortens the disease course of gastrointestinal symptoms, and especially improves the symptoms of the gastrointestinal form of malaria, such as nausea, vomit, stomachache, diarrhoea and the like. Experimental results show that, in the malaria preventing field, the treatment regimen of Weichang Anwan in combination with artemether in the intramuscular injection manner improves the plasmodium kill rate, simultaneously improves the gastrointestinal symptoms significantly, shortens the disease course and plays a secondary efficacy in preventing malaria. The mechanisms of the application are might composed of sterilization, aromatic spasmolysis, relieving pain, shielding and protecting the gastrointestinal mucous membrane, and the like.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, relate to the Chinese medicine system treating the gastroenteropathys such as diarrhoea, dyspepsia, dysentery
The new application of agent Weichangan, is Weichangan application in terms for the treatment of the Congo cloth gastrointestinal type malaria in particular.
Background technology
Gastrointestinal disease treating pill be Lerentang Traditional Chinese Medicine Factory, Tianjin produce without competition for treating the gastrointestinals such as diarrhoea, dyspepsia, dysentery
The conventional famous medicine of tract disease, country's medical insurance medicine, it is loaded into National essential drugs list, is the fine work patent medicine of country's Chinese medicine protection.
Selecting Chinese famous and precious genuine medicinal materials, reasonable recipe, medication is agile, reinforcing and reducing dual-purpose, the cold and heat people having the same aspiration and interest, giving consideration to both the incidental and fundamental, and compatibility is precise and appropriate, work
Skill is reasonable, quality controllable, and refined making forms the fine work patent medicine treating the gastroenteropathys such as diarrhoea, dysentery.
Gastrointestinal disease treating pill has eliminating turbid pathogen with aromatics, regulating QI to relieve pain, effect of stomach invigorating intestinal stasis relieving, does not change institute for turbid damp obstructing in middle-JIAO, dyspepsia
The diarrhoea of cause, Nausea and vomiting, abdomen account, stomachache；Dyspepsia, enteritis, bacillary dysentery is shown in above-mentioned card marquis person.Clinical practice is in infectivity
Diarrhoea: enteritis, bacillary dysentery, rotavirus enteritis, turista etc.；Noninfectious diarrhea: food stagnation of child, infantile dyspepsia, dyspepsia, air-conditioning
Disease, after drinking diarrhoea, gastrointestinal upset etc.；Functional gastrointestinal disorder: functional dyspepsia, irritable bowel syndrome, functional diarrhea etc..
Clinical study results shows: gastrointestinal disease treating pill can obviously relieve the clinical symptoms of non-constipation type IBS patient, is particularly improving abdomen
Bitterly, abdominal distention, nausea and vomiting aspect evident in efficacy, safety is good, can not only alleviate rapidly clinical symptoms, and can significantly improve trouble
The quality of life of person, is to treat the ideal clinical recommendation medicine of non-constipation type IBS at present.
Malaria is the infectious disease that plasmodium parasitizes caused by human body.Through malaria mosquito bite or the blood of input tape plasmodium person
And infect.Different plasmodiums causes tertian malaria, quartan malaria, subtertian malaria and oval malaria respectively.Gastrointestinal type malaria belongs to acute heavy
The one of disease malaria, patient assessment is all with symptom of digestive tract as cardinal symptom, and is partly coated with patient without heating.Mainly show as
Poor appetite, Nausea and vomiting, hematemesis, suffer from abdominal pain, suffer from diarrhoea and have blood in stool, most of gastrointestinal type slow recurrent exerbation of the malaria course of disease, can the several months
Keep recurrence situation.Owing to its clinical manifestation lacks specificity, it is difficult to acute gastroenteritis, Peptic Ulcers, Chronic gastrointestinal diseases
Differentiate mutually, journey of often causing a disease delay and Misdiagnosis.Gastrointestinal endoscopy inspection shows with Stomach duodenum, intestinal mucosa multiple
Property oozing of blood stove (accompanying rotten to the corn and shallow table ulcer) be main, in gastrointestinal mucosa lower floor seen from pathologic finding and ileum fine hair thin vessels be full of
Substantial amounts of plasmodium malaria pigment and phagocyte.Clinical treatment, based on malaria, gives gastral suiting the medicine to the illness in conjunction with patient profiles
Treatment, but often the gastrointestinal symptom persistent period is long after malaria control, and impact is digested and assimilated, patient's body constitution degradation, labor
Power lowers significantly.
Summary of the invention
The invention discloses Weichangan and merge Artemether application in terms of preparation treatment preventing the attack (or recurrence) of malaria improves gastrointestinal symptom, institute
The improvement gastrointestinal symptom stated refers to: Weichangan shortens the course of disease of gastrointestinal symptom, particularly the Congo's cloth gastrointestinal type malaria.
Particularly gastrointestinal disease treating pill improves gastrointestinal type malaria Nausea and vomiting, stomachache, symptom of diarrhea.Preventing the attack (or recurrence) of malaria of the present invention refers to: stomach
Intestinal is positioned on the application in terms of raising plasmodium killing rate.Wherein Weichangan merges Artemether and refers to Artemether: the weight of Weichangan
Amount portion rate is: 1:1.75.
More detailed description of the present invention is as follows:
Weichangan has selected Lignum Aquilariae Resinatum, Lignum Santali Albi, Radix Aucklandiae removing dampness by means of aromatics, regulating QI to relieve pain, sending down the abnormal ascending QI non-return, strong for the pathogeny having loose bowels
Spleen antidiarrheal.Wherein Lignum Aquilariae Resinatum sending down the abnormal ascending QI, Lignum Santali Albi liter gas, the Radix Aucklandiae are longer than the stagnant gas of row the intestines and stomach.Three medicine mutual reinforcements between are for can function of spleen and stomach regulating effectively
The stasis of intestine and small intestine, promoting the circulation of QI to relieve pain, reason spleen antidiarrheal, removing dampness by means of aromatics, expelling cold to relieve vomiting.Be aided with Fructus Aurantii, Cortex Magnoliae Officinalis, regulate the flow of vital energy disappear painful abdominal mass removing dampness dissipate
Long-pending, intestinal stasis relieving helps digestion, and is equipped with the gas medicine in Rhizoma Chuanxiong fortune blood with blood-activating and qi-promoting.The six hollow viscera must keep its unobstructed, also the disease having loose bowels itself be also
A kind of function of human body self-protection.When there being pathogenic factor to invade, when dyspepsia is stagnated, blindly antidiarrheal is closed door and is stayed Kou Zhiyu, therefore we select
With Radix Et Rhizoma Rhei, Semen Crotonis Pulveratum with stasis removing, Radix Et Rhizoma Rhei bitter cold, Semen Crotonis Pulveratum are hot, two medicine fit applications, i.e. avoid excessively cold and heat it
Numbness, enhancing again stasis removing, to remove the evil poison delaied at enteral stagnant.This treating incontinent symptoms (pseudomorph) by dredging method reach toxin expelling antidiarrheal from method for the treatment of
Do not stay the purpose of poison.It is equipped with Fructus Jujubae spleen reinforcing, relaxes the property of medicine.All medicines share, to reach eliminating turbid pathogen with aromatics, regulating QI to relieve pain, stomach invigorating intestinal stasis relieving
Effect, to treat turbid damp obstructing in middle-JIAO, dyspepsia does not change caused diarrhoea, poor appetite, the heart, vomiting, abdominal distention, stomachache, dyspepsia, intestinal
The diseases such as inflammation, bacillary dysentery, viral diarrhea, but Weichangan merges Artemether in Treatment gastrointestinal type malaria and has no report.
Purpose: present invention gastrointestinal disease treating pill merges Artemether injection for treating the Congo cloth gastrointestinal type malaria 253 example.Method:
130 example treatment groups are given oral gastrointestinal disease treating pill and are merged Artemether intramuscular injection, and 123 example matched groups give Artemether intramuscular injection and merge mouth
Take Vitamin B6 Tablets, leukocyte, the change of erythrocyte number and thick film method detection malaria in observe the symptoms improvement degree, just routine
The change of protozoon quantity.
Result: the 5th day symptom of the treatment group patient of 1.100% all disappears, and matched group only has 72%(p < 0.05)；2 control
Treatment group, compared with matched group, can substantially reduce just erythrocyte, the quantity (p < 0.05) of leukocyte in routine；3 treatment group and comparisons
Group is compared and can significantly be killed plasmodium (P < 0.05).
Conclusion: gastrointestinal disease treating pill merges Artemether injection for treating gastrointestinal type malaria not only can significantly improve gastrointestinal symptom,
Shorten the course of disease, moreover it is possible to play the effect of auxiliary malaria.
Gastrointestinal type malaria clinical manifestation based on Nausea and vomiting, suffer from abdominal pain, suffer from diarrhoea and heating, accidental digestive tract hemorrhage, clinical
On easily obscure mutually with acute gastrointestinal disease, rate of missed diagnosis is high, but cure rate is high.The author-2015 years in June, 2,013 6 participating nations
Medical team of family, during helping the Congo's cloth, trial gastrointestinal disease treating pill merges Artemether injection for treating gastrointestinal type malaria, existing by result
It is reported as follows:
Material and method
Object of study
Choose in July, 2013 in December ,-2014 and go to gastrointestinal type malaria patients 253 example that in the Congo's cloth, the most friendly hospital just controls,
Random digits table is used to be randomly divided into treatment group and matched group, treatment group 130 example, matched group 123 example.Treatment group male 120
Example, women 10 example, age 24-53 year；Matched group male 110 example, women 13 example.Two groups of patients at sex, age, be in a bad way
The equal no difference of science of statistics of the indexs such as degree (p < 0.05).
Research medication
5 days courses for the treatment of of treatment group Artemether injection (80mg/ props up, intramuscular injection, India).1st day, the 2nd day each 240mg,
3rd day, the 4th day, the 5th day each 160mg, oral gastrointestinal disease treating pill (Lerentang Traditional Chinese Medicine Factory, Tianjin.) 4 tablets/time, 3 times/day, totally 7 days；
Matched group, 5 days courses for the treatment of (with treatment group) of Artemether intramuscular injection, Vitamin B6 Tablets (Beijing Shuan He pharmaceutical factory) 20mg/ days, altogether clothes
7 days.
The method of inspection
Patient enters to organize first day, the 7th day thick film method detection plasmodium, routine blood test, just routine.Plasmodium number before and after comparison therapy
The change of amount, the just improvement degree of conventional white cell, the change of erythrocyte number and patients symptomatic.
Result
Table 1 Weichangan merges the impact on gastrointestinal type malaria gastrointestinal symptoms of the Artemether injection
Table 2 Weichangan merges the impact that Artemether injection is just conventional on gastrointestinal type malaria
Compare with matched group the 1st day erythrocyte, quantity of leucocyte, p > 0.05；The 7th day RBC number for the treatment of group,
Leukocyte count compares with matched group, p < 0.05；Treatment group the 7th day RBC number, leukocyte count and within the 1st day, compare, p < 0.05
Table 3 Weichangan merges the impact on gastrointestinal type malarial Protozoa quantity of the Artemether injection
Within 1st day, compare with matched group, p > 0.05；Treatment group, matched group compare for the 1st day and the 7th day, p < 0.05；
Treatment group compares with matched group on the 7th day, p < 0.05
3 conclusions
Table 1 result shows: the first day enters to organize patients symptomatic similar, and within the 2nd day, treatment group has 8%(11 example) patients symptomatic's disappearance, and compare
Group only 0.8%(1 example) patients symptomatic's disappearance；Within 3rd day, 28% patients symptomatic disappears, and matched group only has 0.48%；Treatment in 4th day
The patients symptomatic of group 86% disappears, and matched group only has 15%；The patients symptomatic of the 5th day treatment group 100% disappears, and matched group is only
The patients symptomatic having 27% disappears.The even only 72%(87 example by the 7th day) patients symptomatic disappear, after residue patient's symptomatic treatment
2 weeks (14 days) fully recover.Show that gastrointestinal disease treating pill can be obviously improved gastrointestinal type malaria Nausea and vomiting, stomachache, symptom of diarrhea.
Table 2 result shows: enter first day treatment group of group and matched group patient just routine all has leukocyte and erythrocyte, both
Between have no notable difference；After treatment, within the 7th day, treatment group just conventional erythrocyte, leukocyte count all substantially reduce, p < 0.05,
But matched group has no notable difference.
Table 3 result shows: enter first day treatment group of group and matched group patient's plasmodium quantity has no significant change, it was demonstrated that suffer from
Person's malaria coincident with severity degree of condition no significant difference.After antimalarial treatments, treatment group and matched group the 1st day and the 7th day ratio, plasmodium
Quantity all significantly reduces, p < 0.05.But plasmodium killing rate significantly improves, compared with matched group after treatment group adds Weichangan
There are notable difference, p < 0.05.
Discuss
Gastrointestinal type malaria belongs to the one of acute severe malaria, and patient assessment is all with symptom of digestive tract as cardinal symptom, and half applies
Above patient is without heating.Mainly show as poor appetite, Nausea and vomiting, hematemesis, suffer from abdominal pain, suffer from diarrhoea and have blood in stool, most of gastrointestinal type malarias
The slow recurrent exerbation of disease journey, can keep the several months recurring situation.Owing to its clinical manifestation lacks specificity, it is difficult to acute gastrointestinal
Inflammation, Peptic Ulcers, Chronic gastrointestinal diseases differentiate mutually, journey of often causing a disease delay and Misdiagnosis.Gastrointestinal endoscopy inspection show with
Stomach duodenum, intestinal mucosa multiple oozing of blood stove (accompanying rotten to the corn and shallow table ulcer) is main, under gastrointestinal mucosa seen from pathologic finding
Layer and ileum fine hair thin vessels are full of substantial amounts of plasmodium malaria pigment and phagocyte.Clinical treatment based on malaria, in conjunction with
Patient profiles gives gastral symptomatic treatment, but often the gastrointestinal symptom persistent period is long after malaria control, impact digestion
Absorbing, patient's body constitution degradation, labour force is lowered significantly.
Malaria is early recognized by traditional medicine, "Nei Jing" cloud " being attacked by pathogenic heat in summer, autumn must malaria ", and Dan Xi says that " malaria of wind summer-heat is many
Because the moon in summer has a rest at cool place ".Jing-Yue Complete Works " subtertian malaria one demonstrate,proves the ground of only south of the Five Ridges malarial region it " the Congo's cloth is positioned at western central Africa, ground
Around equator, place, have a humid climate sweltering heat, and mosquito wreaks havoc, similar with China torrid areas weather conditions." Standards of Diagnosis and Treatment " " subtertian malaria
Person, the gas holding haze miasma small stream source steaming poison under the arm causes so, malicious bitter inflammation on the south ridge, and seldom, people is many, and this is sick for dampness ... " divide by determining the pathogenesis of ZANG-FU disease based on the differentiation of symptoms and signs
Type sees that gastrointestinal type malaria belongs to " spleen-malaria " category of the traditional Chinese medical science, and disease sees that " alternate attacks of chills and fever, suffers from abdominal pain with time cold, and borborygmus during heat, ring antiperspirant
Go out." method for the treatment of is with removing dampness by means of aromatics, spleen invigorating preventing the attack (or recurrence) of malaria is main.
Gastrointestinal disease treating pill is the common medicine for the treatment of diarrhoea, and it is by the Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii (parched with bran), Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis
11 taste Chinese medicine composition such as (processed with Rhizoma Zingiberis Recens), Moschus, Semen Crotonis Pulveratum, Fructus Jujubae (enucleation), Rhizoma Chuanxiong, its gas fragrance, sweet in the mouth, pungent, bitter, there is fragrance
Change turbid, regulating QI to relieve pain, the effect of stomach invigorating intestinal stasis relieving, reinforcing and reducing dual-purpose, the cold and heat people having the same aspiration and interest, giving consideration to both the incidental and fundamental.For turbid damp obstructing in middle-JIAO, accumulation of food in the stomach and intes tine due to indigestion
The above-mentioned disease persons such as caused diarrhoea, Nausea and vomiting, abdominal distention, stomachache and dyspepsia, enteritis, bacillary dysentery, can improve gastrointestinal merit
Energy, spasmolytic, antidiarrheal, pathogenic entero becteria multiple to escherichia coli, dysentery bacterium etc. has bacteriostasis.Zoopery confirms Weichangan
Ball has therapeutical effect to by the mice irritable bowel syndrome of this bright induction in ground new；Induced by endotoxin causes mice shock death has intestinal to stick
Film shielding protection effect.
Test result indicate that gastrointestinal disease treating pill merges the therapeutic scheme of Artemether intramuscular injection, significantly improve while preventing the attack (or recurrence) of malaria
Gastrointestinal symptom, shortens the course of disease, and plays auxiliary effect of malaria.Its mechanism is probably because it has sterilization, fragrance solution
Caused by convulsion pain relieving, gastrointestinal mucosa barrier protection function.
Detailed description of the invention:
The present invention is described below by specific embodiment.Unless stated otherwise, technological means used in the present invention is
Method known in those skilled in the art.It addition, embodiment is interpreted as illustrative, and the model of the unrestricted present invention
Enclosing, the spirit and scope of the invention are limited only by the claims that follow.To those skilled in the art, without departing substantially from this
On the premise of bright spirit and scope, the various changes or the change that carry out the material component in these embodiments and consumption also belong to
In protection scope of the present invention.
Embodiment 1
[prescription]
Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g,
Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g.
Ten tastes more than [preparation method], Semen Crotonis Pulveratum, Moschus are respectively crushed into fine powder；Eight tastes such as remaining Lignum Aquilariae Resinatum are ground into fine powder, with
Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, sieve, then be mixed with acceptable adjuvant on any one or more of pharmaceutics
Oral formulations.
Claims (3)
1. Weichangan merges Artemether application in terms of preparation treatment preventing the attack (or recurrence) of malaria improves gastrointestinal symptom, described improvement gastrointestinal tract
Symptom refers to: Weichangan shortens the course of disease of gastrointestinal symptom.
2. Weichangan merges Artemether application in terms of preparation treatment preventing the attack (or recurrence) of malaria improves gastrointestinal symptom, described improvement gastrointestinal tract
Symptom refers to: gastrointestinal disease treating pill improves gastrointestinal type malaria Nausea and vomiting, stomachache, symptom of diarrhea.
3. Weichangan merges Artemether application in terms of preparation treatment preventing the attack (or recurrence) of malaria improves gastrointestinal symptom, and described preventing the attack (or recurrence) of malaria refers to
It is: Weichangan application in terms of improving plasmodium killing rate.
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