CN105853545A - 一种用于治疗牛皮癣外用膏药的制备方法 - Google Patents

一种用于治疗牛皮癣外用膏药的制备方法 Download PDF

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CN105853545A
CN105853545A CN201610276469.7A CN201610276469A CN105853545A CN 105853545 A CN105853545 A CN 105853545A CN 201610276469 A CN201610276469 A CN 201610276469A CN 105853545 A CN105853545 A CN 105853545A
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李建华
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Abstract

本发明公开了一种用于治疗牛皮癣外用膏药的制备方法。先按重量份组成称取各原料,然后粉碎研磨制成药粉,混合搅拌,加入芝麻油泡制;然后用小火加热熬制,得熬制物,滤除熬制物中的药渣,得药液;往药液中添加红丹,搅拌均匀,熬制成半成品药膏;最后将上步半成品药膏凉水浸泡7‑10天去火毒,然后敷于帆布上,制成膏药。本发明方法制得膏药对于治疗牛皮癣病症具有吸收快、奏效迅速、药源充足、疗效高、无不良反应、疗效显著持久等优点。同时本制备方法工艺独到,方法简单,成本低,节能环保,同时能显著缩短生产周期,降低生产成本及能耗,具有显著的竞争优势和广泛的应用前景。

Description

一种用于治疗牛皮癣外用膏药的制备方法
技术领域
本发明涉及一种外用中药,尤其涉及一种用于治疗牛皮癣外用膏药的制备方法。
背景技术
牛皮癣即银屑病(psoriasis),是一种常见的慢性复发性炎症性皮肤病,特征性损害为红色丘疹或斑块上覆有多层银白色鳞屑,好发于四肢伸侧、头皮和背部,严重皮损可泛发全身,并可出现高热、脓疱、红皮病样改变以及全身大小关节病变。本病与祖国医学文献中记载的“白疕”、“风”、“蛇虱”相类似。如。《医宗金鉴》记载:“此证俗名蛇虱,生于皮肤,形如疹疥,色白而痒,搔起白皮。”又如。外科证治全书〃白疕(一名风)记载:“皮肤燥痒起如疹疥而色白,搔之屑起,渐至肢体枯燥,坼裂血出痛楚”。此病顽固,久治不愈,愈后极易复发。对于牛皮癣的治疗包括外涂药物和内服药物,内服药物往往存在较多的药物副作用,而现有的外涂药物通常选用糖皮质激素制剂、0.1%~2%蒽林软膏、焦油制剂(包括2%~10%煤焦油、松焦油、黑豆馏油和糠馏油)、0.05%~0.1-顺维甲酸霜、0.005%卡泊三醇(钙泊三醇)软膏、0.005%~0.01%芥子气软膏、5%氟尿嘧啶(5-Fu)软膏,以及光疗,生物抑制剂等,虽然取得了一定成果,但并不理想,有的起效慢,有的副作用大,会对皮肤产生一些伤害,愈后易复发。而中医传统的外科膏药是运用中药归经原则,运用药物互相协调为用的效能,组成多味药物的大复方,以发挥药物的良好效果。由于膏药用于肌表薄贴,所以膏药中取气味具厚的药物,并加以引药率领群药,开结行滞直达病所。药物在患处通过皮肤渗透达皮下组织,在局部产生药物浓度的相对优势,从而发挥较强的药理作用。此外,因膏药中有些刺激性强的药物,强刺激通过神经反射,可以调节肌体功能促进抗体形成,提高人体免疫力。药物穿通皮肤及黏膜后,经过血管或淋巴管进入体循环,也可产生全身性药物作用。因此,越来越多科研人员开始研究通过中医膏药治疗牛皮癣病症。
发明内容
本发明的目的在于提供一种用于治疗牛皮癣外用膏药的制备方法,本发明药物所选药材配伍相宜,符合中医药学和现代医药学理论,对治疗牛皮癣引起的各种症状具有显著的效果,疗程短,见效快,疗效可靠,无任何毒副作用,能够达到标本兼治的目的。
为了实现上述目的,本发明提供了一种用于治疗牛皮癣外用膏药的制备方法,包括以下步骤:先按重量份组成称取下述各原料:丹皮10-20份、白鲜皮15-25份、草乌10-16份、防风15-25份、苦楝子8-15份、乳香15-25份、僵蚕7-10份、蜈蚣4-5份、山梭7-10份、没药10-20份、忍冬藤10-30份、麻油500-600份,然后将除了红丹和麻油以外的原料进行粉碎研磨制成药粉,混合搅拌,加入麻油泡制5-7天; 然后用小火加热熬制,得熬制物,滤除熬制物中的药渣,得药液;往药液中添加红丹,搅拌均匀,熬制成半成品药膏; 最后将上步半成品药膏凉水浸泡7-10天去火毒,然后敷于帆布上,制成膏药。
所述药粉的细度为100-150目。
所述草乌粉碎研磨前经过预处理,预处理方法如下:将的草乌用水浸泡4-6小时,取出;再用水煮1.5-3个小时,取出,晒20-24小时后切薄片,干燥。
所述乳香粉碎研磨前经过预处理,预处理方法如下:将洗净的乳香放入锅内用文火炒至表面稍见融化时,取出放凉备用。
1.所述没药粉碎研磨前经过预处理,预处理方法如下:将洗净的没药放入锅内炒至表面熔化时,喷洒米醋,继续炒至外层明亮光透,取出放凉备用。
有益效果:本发明方法制得膏药对于治疗牛皮癣病症具有吸收快、奏效迅速、药源充足、疗效高、无不良反应、疗效显著持久等优点。同时本制备方法工艺独到,方法简单,成本低,节能环保,同时能显著缩短生产周期,降低生产成本及能耗,具有显著的竞争优势和广泛的应用前景。
具体实施方式
实施例1
一种用于治疗牛皮癣外用膏药的制备方法,包括以下步骤:先按重量份组成称取下述各原料:丹皮10份、白鲜皮15份、草乌10份、防风15份、苦楝子8份、乳香15份、僵蚕7份、蜈蚣4份、山梭7份、没药10份、忍冬藤10份、麻油500份,然后将除了红丹和麻油以外的原料进行粉碎研磨制成药粉,混合搅拌,加入麻油泡制5-7天; 然后用小火加热熬制,得熬制物,滤除熬制物中的药渣,得药液;往药液中添加红丹,搅拌均匀,熬制成半成品药膏; 最后将上步半成品药膏凉水浸泡7-10天去火毒,然后敷于帆布上,制成膏药。
其中药粉的细度为100-150目。草乌粉碎研磨前经过预处理,预处理方法如下:将的草乌用水浸泡4-6小时,取出;再用水煮1.5-3个小时,取出,晒20-24小时后切薄片,干燥。乳香粉碎研磨前经过预处理,预处理方法如下:将洗净的乳香放入锅内用文火炒至表面稍见融化时,取出放凉备用。没药粉碎研磨前经过预处理,预处理方法如下:将洗净的没药放入锅内炒至表面熔化时,喷洒米醋,继续炒至外层明亮光透,取出放凉备用。
实施例2
一种用于治疗牛皮癣外用膏药的制备方法,包括以下步骤:先按重量份组成称取下述各原料:丹皮20份、白鲜皮25份、草乌16份、防风25份、苦楝子15份、乳香25份、僵蚕10份、蜈蚣5份、山梭10份、没药20份、忍冬藤30份、麻油600份,然后将除了红丹和麻油以外的原料进行粉碎研磨制成药粉,混合搅拌,加入麻油泡制5-7天; 然后用小火加热熬制,得熬制物,滤除熬制物中的药渣,得药液;往药液中添加红丹,搅拌均匀,熬制成半成品药膏; 最后将上步半成品药膏凉水浸泡7-10天去火毒,然后敷于帆布上,制成膏药。
其中药粉的细度为100-150目。草乌粉碎研磨前经过预处理,预处理方法如下:将的草乌用水浸泡4-6小时,取出;再用水煮1.5-3个小时,取出,晒20-24小时后切薄片,干燥。乳香粉碎研磨前经过预处理,预处理方法如下:将洗净的乳香放入锅内用文火炒至表面稍见融化时,取出放凉备用。没药粉碎研磨前经过预处理,预处理方法如下:将洗净的没药放入锅内炒至表面熔化时,喷洒米醋,继续炒至外层明亮光透,取出放凉备用。
实施例3
临床资料:作为治疗牛皮癣的膏药,选择确诊的牛皮癣患者70例临床观察,其中男性40例,女性30例,年龄50-73岁,病程1-6年;将患处洗净擦干,将膏药敷于患处,每日1副,12天为1个疗程,连续使用2-3个疗程。疗效判定:(1)治愈:症状全部消失,身体恢复正常。(2)显效:症状明显减轻,身体明显好转。(3)有效:症状有所减轻,身体有所好转。(4)无效:通过治疗后症状无减轻或加重。由上述临床验证结果可知,用本发明外敷损伤患处,治疗牛皮癣患者70例,取得了较好的临床疗效,治愈64例,显效和有效共6例,有效率达到100%,用药期间未发现局部及全身过敏现象,用药安全。典型病例举例:1、吴某,女,51岁,浙江义乌人。患者面部及上肢大小不一淡白色斑点,上覆有少量鳞屑,轻度瘙痒。 外用其他癣药、口服中药等治疗,病情反复发作,患者及家人很苦恼。后来我院就诊,使用本发明膏药1个疗程后,上述症状明显好转,继续使用本发明膏药1个疗程后,上述症状消失,1年后随访无复发。
2、陈某,男,58岁,辽宁丹东人。患者见前胸、后背、两腿多处呈不规则点状病灶,发红,边沿清楚,有鳞屑,伴有瘙痒,阴雨天明显。使用1个疗程后,患者身体恢复良好,使用本发明膏药2个疗程后,患者自述原症状早已完全消失,日常生活、工作与患病前无异。

Claims (5)

1.一种用于治疗牛皮癣外用膏药的制备方法,其特征在于,包括以下步骤:先按重量份组成称取下述各原料:丹皮10-20份、白鲜皮15-25份、草乌10-16份、防风15-25份、苦楝子8-15份、乳香15-25份、僵蚕7-10份、蜈蚣4-5份、山梭7-10份、没药10-20份、忍冬藤10-30份、麻油500-600份,然后将除了红丹和麻油以外的原料进行粉碎研磨制成药粉,混合搅拌,加入麻油泡制5-7天; 然后用小火加热熬制,得熬制物,滤除熬制物中的药渣,得药液;往药液中添加红丹,搅拌均匀,熬制成半成品药膏; 最后将上步半成品药膏凉水浸泡7-10天去火毒,然后敷于帆布上,制成膏药。
2.根据权利要求 1所述的一种用于治疗牛皮癣外用膏药的制备方法,其特征在于 :所述药粉的细度为100-150目。
3.根据权利要求1所述的一种用于治疗牛皮癣外用膏药的制备方法,其特征在于 :所述草乌粉碎研磨前经过预处理,预处理方法如下:将的草乌用水浸泡4-6小时,取出;再用水煮1.5-3个小时,取出,晒20-24小时后切薄片,干燥。
4.根据权利要求1所述的一种用于治疗牛皮癣外用膏药的制备方法,其特征在于 :所述乳香粉碎研磨前经过预处理,预处理方法如下:将洗净的乳香放入锅内用文火炒至表面稍见融化时,取出放凉备用。
5.根据权利要求1所述的一种用于治疗牛皮癣外用膏药的制备方法,其特征在于 :所述没药粉碎研磨前经过预处理,预处理方法如下:将洗净的没药放入锅内炒至表面熔化时,喷洒米醋,继续炒至外层明亮光透,取出放凉备用。
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CN105832832A (zh) * 2016-04-29 2016-08-10 苏州市天灵中药饮片有限公司 一种牛皮癣膏药的制备方法

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CN105832884A (zh) * 2016-04-29 2016-08-10 苏州市天灵中药饮片有限公司 一种治疗牛皮癣中医膏药的制备方法
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