CN104288604B - 一种治疗脑梗死的中药组合物 - Google Patents

一种治疗脑梗死的中药组合物 Download PDF

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CN104288604B
CN104288604B CN201410519637.1A CN201410519637A CN104288604B CN 104288604 B CN104288604 B CN 104288604B CN 201410519637 A CN201410519637 A CN 201410519637A CN 104288604 B CN104288604 B CN 104288604B
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cerebral infarction
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rhizoma
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陈涛
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China Three Gorges University CTGU
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Abstract

本发明提供一种治疗脑梗死的中药组合物。脑梗死属祖国医学“中风”范畴。本病病机复杂,多数医家认为本病的基本病机为“本虚标实”,并指出中风初期以“痰、火、风、瘀”为主,后期以“虚、瘀”为主。治疗应以清热熄风,益气通络,活血化瘀为治则。为此,选择桃仁,红花,菊花,石决明,荷叶,柴胡,天麻,薏苡仁,炒白术,川芎,钩藤,夏枯草,胆南星,赤芍,地龙,石菖蒲,丹参,制成汤剂,供患者服用。经临床观察,总有效率达到100%,且安全有效、成本低廉、便于掌握,值得临床推广应用。

Description

一种治疗脑梗死的中药组合物
技术领域
本发明涉及一种中药组合物,尤其涉及一种治疗脑梗死的中药组合物的应用。
背景技术
脑梗死是脑血液供应障碍引起的脑部病变。脑梗死主要是由于脑动脉出现粥样硬化和血栓形成,使管腔狭窄甚至闭塞,导致局灶性的脑供血不足。也有因异常物体(固体、液体、气体)沿血液循环进入脑动脉或供应脑血液循环的颈部动脉,造成血流阻断或血流量骤减而产生相应支配区域脑组织软化坏死。前者称为动脉硬化性血栓形成性脑梗死,占本病的40%~60%,后者称为脑栓塞占本病的15%~20%。此外,尚有一种腔隙性脑梗死,系高血压小动脉硬化引起的脑部动脉深穿支闭塞形成的微梗死。脑梗死是脑血管病中最常见者,约占75%,病死率平均10%~15%,致残率极高,且极易复发,一直是脑血管病领域的研究热点。目前还没有针对脑血栓形成的所有病人都能采用的统一的、规范化的西医治疗方案,只能实行根据每个病人的具体情况和病期,选用某种或某些治疗的个体化原则。
发明内容
本发明的目的是提供一种治疗脑梗死的中药组合物。脑梗死属祖国医学“中风”范畴。本病病机复杂,多数医家认为本虚标实为本病的基本病机,并指出中风初期以“痰、火、风、瘀”为主,后期以“虚、瘀”为主。应以清热熄风,益气通络,活血化瘀为治则。
本发明的目的是通过以下方案实现的。该治疗脑梗死的中药组合物由以下重量份的中药组成:桃仁8-15份、红花8-12份、菊花9-15份、石决明9-15份、荷叶9-12份、柴胡9-12份、天麻9-12份、薏苡仁25-35份、炒白术9-12份、川芎6-12份、钩藤12-20份、夏枯草10-15份、胆南星9-12份、赤芍1020份、地龙9-15份、石菖蒲10-20份、丹参25-35份。
优选的,该治疗脑梗死的中药组合物由以下重量份的中药制成:桃仁10份、红花10份、菊花10份、石决明10份、荷叶10份、柴胡10份、天麻10份、薏苡仁30份、炒白术10份、川芎10份、钩藤15份、夏枯草12份、胆南星10份、赤芍15份、地龙10份、石菖蒲15份、丹参30份。
本发明所用桃仁是蔷薇科植物桃或山桃的成熟种子。桃仁具有活血祛瘀,润肠通便,止咳平喘的功效。
本发明所用红花是菊科植物红花的筒状花冠。红花具有活血通经,祛瘀止痛的功效。
本发明所用菊花是菊科植物菊的干燥头状花序。菊花具有疏散风热,平抑肝阳,清肝明目,清热解毒的功效。
本发明所用石决明是鲍科动物杂色鲍、皱纹盘鲍(毛底石决明)、羊鲍、澳洲鲍、耳鲍或白鲍的贝壳。石决明具有平肝潜阳,清肝明目的功效。
本发明所用荷叶是睡莲科植物莲的叶片。荷叶具有清暑利湿,升阳止血的功效。
本发明所用柴胡是伞形科植物柴胡或狭叶柴胡的干燥根。柴胡具有解表退热,疏肝解郁,升举阳气的功效。
本发明所用天麻是兰科植物天麻的干燥块茎。天麻具有息风止痉,平抑肝阳,祛风通络的功效。
本发明所用薏苡仁是乔本科植物薏苡的干燥成熟种子。薏苡仁具有利水消肿,渗湿,健脾,除痹,清热排脓的功效。
本发明所用炒白术是将白术片用麸炒至浅黄色。白术具有健脾益气,燥湿利水的功效。
本发明所用川芎是伞形科植物川芎的根茎。川芎具有活血行气,祛风止痛的功效。
本发明所用钩藤是茜草科植物钩藤、大叶钩藤、毛钩藤、华钩藤或无柄果钩藤的干燥带钩茎枝。钩藤具有清热平肝,息风定惊的功效。
本发明所用夏枯草是唇形科植物夏枯草的干燥果穗。夏枯草具有清热泻火,明目,散结消肿的功效。
本发明所用胆南星是天南星用牛胆汁拌制而成。胆南星具有清热化痰,息风定惊的功效。
本发明所用赤芍是毛茛科植物赤芍或川赤芍的干燥根。赤芍具有清热凉血,散瘀止痛的功效。
本发明所用地龙是钜蚓科动物参环毛蚓、通俗环毛蚓、威廉环毛蚓或栉盲环毛蚓的干燥体。地龙具有清热定惊,通络,平喘,利尿。
本发明所用石菖蒲是天南星科植物石菖蒲的干燥根茎。石菖蒲具有开窍醒神,化湿和胃,宁神益志的功效。
本发明所用丹参是唇形科植物丹参的根。丹参具有活血调经,祛瘀止痛,凉血消痈,除烦安神的功效。
具体而言,本发明采用的技术方案是,提供了一种治疗脑梗死的中药组合物,由桃仁,红花,菊花,石决明,荷叶,柴胡,天麻,薏苡仁,炒白术,川芎,钩藤,夏枯草,胆南星,赤芍,地龙,石菖蒲,丹参组成。
上述治疗脑梗死的中药组合物,其特征在于该中药组合物是由桃仁8-15份、红花8-12份、菊花9-15份、石决明9-15份、荷叶9-12份、柴胡9-12份、天麻9-12份、薏苡仁25-35份、炒白术9-12份、川芎6-12份、钩藤12-20份、夏枯草10-15份、胆南星9-12份、赤芍10-20份、地龙9-15份、石菖蒲10-20份、丹参25-35份组成。
上述治疗脑梗死的中药组合物,其特征在于该中药组合物是由桃仁10份、红花10份、菊花10份、石决明10份、荷叶10份、柴胡10份、天麻10份、薏苡仁30份、炒白术10份、川芎10份、钩藤15份、夏枯草12份、胆南星10份、赤芍15份、地龙10份、石菖蒲15份、丹参30份组成。
本发明进一步采用的技术方案是,提供一种治疗脑梗死的中药组合物,该中药组合物可以支撑临床常用剂型。
本发明进一步采用的技术方案是,将桃仁,红花,菊花,石决明,荷叶,柴胡,天麻,薏苡仁,炒白术,川芎,钩藤,夏枯草,胆南星,赤芍,地龙,石菖蒲,丹参混合,加水没过药材,然后慢火煎煮至水沸后再煮20分钟,过滤后得到药汁,重复上述过程两次,将所得药汁混合即得汤剂。
另外,本发明的中药组合物成本低廉,所用中药都是常见中药,给药方式简便,因此适合于基层医院,特别是不发达地区的推广应用。
临床资料
1、一般资料 病例均为宜昌市中心医院门诊及住院病人。21例中,男13例,女8例,年龄53-69岁,平均年龄62岁,病程3个月到10年,平均2年。
2、诊断标准 (1)可有动脉硬化、高血压、糖尿病、心房颤动等病史。(2)头痛、头昏、头晕、眩晕、恶心呕吐、运动性和(或)感觉性失语甚至昏迷。(3)双眼向病灶侧凝视中枢性面瘫及舌瘫、假性延髓性麻痹如饮水呛咳和吞咽困难。(4)肢体偏瘫或轻度偏瘫、偏身感觉减退、步态不稳、肢体无力、大小便失禁。(5)脑部CT、MRI检查可显示梗死部位和范围,并可排除脑出血、瘤卒中和炎症性疾病。(6)常有T1A中风病史。
3治疗方法采用中药组合物。桃仁10g、红花10g、菊花10g、石决明10g、荷叶10g、柴胡10g、天麻10g、薏苡仁30g、炒白术10g、川芎10g、钩藤15g、夏枯草12g、胆南星10g、赤芍15g、地龙10g、石菖蒲15g、丹参30g。两日一剂,水煎,每日3次内服。
患者在治疗期间注意养成良好的生活习惯,均避免高脂饮食,戒烟酒,忌过劳,避免精神紧张,消除顾虑。7天为一个疗程,2到3个疗程后观察疗效。
疗效版定标准根据治疗前后症状总分,按公式求出疗效指数以判定疗效。疗效指数(治疗前症状总分-治疗后症状总分)/治疗前症状总分×100%。疗效指数<25%为无效;26%-50%为好转;51%-85%为显效;>86%为临床治愈
治疗结果治疗后统计疗效,治愈6例(28.6%),显效7例(33.3%),好转8例(38.1%)。该中药组合总有效率达100%。
具体实施例
以下是本发明的典型病例
病例一:周某,男,50岁,患者头痛,头昏,头皮发麻,四肢偶感麻木,舌体发胖,色暗。临床诊断患有轻微脑梗(痰瘀交阻)。服用本发明的中药水煎液,每日3次,1次250ml,服用7天后,头昏、头皮发麻症状缓解;继续服用30天后,头昏,四肢麻木症状明显改善,精神转佳。
病例二:袁某,女,67岁,患者劲椎痛,颈后血管疼痛,可见明显静脉曲张,咳嗽;舌质淡紫有瘀斑。临床诊断患有脑梗(痰瘀交阻)。服用本发明的中药水煎液,每日3次,1次250ml,服用10天后,颈椎疼痛明显减轻。
病例三:王某,男,51岁,患者头痛头昏,四肢困重,口干口苦但不欲饮,纳呆,尿黄,大便不爽,舌苔黄腻;既往有高血压。临床诊断患者有脑梗(湿热中阻)。服用本发明的中药水煎液,每日3次,一次250ml,服用7天后,头昏头痛缓解,自觉浑身轻松,大小便基本正常,饮食转佳。
病例四:李某,女,68岁,患者头痛,头晕,头胀,胸部疼痛,偶感剧痛,颈椎不适。临床诊断有脑梗(痰瘀闭阻)。服用本发明的中药水煎液,每日3次,1次250ml,服用12天后,头痛头昏改善,剧痛感次数减少,头胀好转;继续服用24天后,头痛头昏明显好转,剧痛感消失,颈椎改善,精神转佳。
病例五:司某,女,55岁,,患者头昏,头胀,耳鸣,全身乏力,多处骨骼异常,四肢发麻,下肢尤甚。临床诊断患者有脑梗(肝肾亏虚)。服用本发明的中药水煎液,每日3次,1次250ml,服用7天后,头昏头胀好转,四肢发麻改善,自觉体力增强,精神转佳。
病例六:杨某,女,59岁,患者经常头晕,作呕,头闷,低头便感头晕,长期睡眠不好,便秘,常感乏力。临床诊断有脑梗(气血亏虚)。服用本发明的中药水煎液,每日3次,1次250ml,服用7天后,头晕头闷改善,睡眠好转,体力增强,精神好转。
病例七:吴某,女,53岁,患者头昏头晕,颈椎不适,四肢麻木,全身乏力,睡眠不好,舌质紫暗,有瘀斑。临床诊断有脑梗(气滞血瘀)。服用本发明的中药水煎液,每日3次,1次250ml,服用7天后,头昏头晕改善,四肢麻木好转;继续服用30天后,颈椎不适好转,头昏头晕明显改善,四肢麻木基本消失,睡眠明天好转;连续服用60天后,症状痊愈。
病例八:周某,男,65岁,患者头昏头疼,上肢麻木,口干,医学影像学检查结果示:基地动脉起始部血管腔轻度狭窄,右侧椎动脉较左侧略细。临床诊断有脑梗(气血痰阻)。服用本发明的中药水煎液,每日3次,1次250ml,服用10天后,头疼缓解;继续服用30天后,头昏头疼明显好转,上肢麻木感基本消失,身体状况基本恢复正常。

Claims (2)

1.一种治疗脑梗死的中药组合物,其特征在于该中药组合物由以下重量份的中药制成:桃仁8-15份、红花8-12份、菊花9-15份、石决明9-15份、荷叶9-12份、柴胡9-12份、天麻9-12份、薏苡仁25-35份、炒白术9-12份、川芎6-12份、钩藤12-20份、夏枯草10-15份、胆南星9-12份、赤芍10-20份、地龙9-15份、石菖蒲10-20份、丹参25-35份。
2.根据权利要求1所述的一种治疗脑梗死的中药组合物,其特征在于该中药组合物由以下重量份的中药制成:桃仁10份、红花10份、菊花10份、石决明10份、荷叶10份、柴胡10份、天麻10份、薏苡仁30份、炒白术10份、川芎10份、钩藤15份、夏枯草12份、胆南星10份、赤芍15份、地龙10份、石菖蒲15份、丹参30份。
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