CN105832832A - 一种牛皮癣膏药的制备方法 - Google Patents
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Abstract
本发明公开了一种牛皮癣膏药的制备方法。先称取原料，然后将上述原料用流通蒸气加热杀灭微生物的方法，灭菌干燥后研成药粉、拌匀、清除杂质；然后放入锅内微火炒黄，待冷却后置于容器内，加入麻油密封浸泡；然后用小火加热熬制，得熬制物，滤除熬制物中的药渣，得药液；药液中添加红丹，熬制成半成品药膏；最后去火毒，然后敷于帆布上，制成膏药。本发明方法制得膏药对于治疗牛皮癣病症具有杀菌止痒、去腐生肌、温中止痛药效，加快体癣斑片消失和新牛皮癣肌面重生，来快速有效治愈各类牛皮癣。同时本制备方法工艺独到，方法简单，成本低，节能环保，同时能显著缩短生产周期，降低生产成本及能耗，具有显著的竞争优势和广泛的应用前景。
Description
技术领域
本发明涉及一种外用中药，尤其涉及一种牛皮癣膏药的制备方法。
背景技术
牛皮癣即银屑病(psoriasis)，是一种常见的慢性复发性炎症性皮肤病，特征性损害为红色丘疹或斑块上覆有多层银白色鳞屑，好发于四肢伸侧、头皮和背部，严重皮损可泛发全身，并可出现高热、脓疱、红皮病样改变以及全身大小关节病变。本病与祖国医学文献中记载的“白疕”、“风”、“蛇虱”相类似。如。《医宗金鉴》记载：“此证俗名蛇虱，生于皮肤，形如疹疥，色白而痒，搔起白皮。”又如。外科证治全书〃白疕(一名风)记载：“皮肤燥痒起如疹疥而色白，搔之屑起，渐至肢体枯燥，坼裂血出痛楚”。此病顽固，久治不愈，愈后极易复发。对于牛皮癣的治疗包括外涂药物和内服药物，内服药物往往存在较多的药物副作用，而现有的外涂药物通常选用糖皮质激素制剂、0.1%～2%蒽林软膏、焦油制剂(包括2%～10%煤焦油、松焦油、黑豆馏油和糠馏油)、0.05%～0.1-顺维甲酸霜、0.005%卡泊三醇(钙泊三醇)软膏、0.005%～0.01%芥子气软膏、5%氟尿嘧啶(5-Fu)软膏，以及光疗，生物抑制剂等，虽然取得了一定成果，但并不理想，有的起效慢，有的副作用大，会对皮肤产生一些伤害，愈后易复发。而中医传统的外科膏药是运用中药归经原则，运用药物互相协调为用的效能，组成多味药物的大复方，以发挥药物的良好效果。由于膏药用于肌表薄贴，所以膏药中取气味具厚的药物，并加以引药率领群药，开结行滞直达病所。药物在患处通过皮肤渗透达皮下组织，在局部产生药物浓度的相对优势，从而发挥较强的药理作用。此外，因膏药中有些刺激性强的药物，强刺激通过神经反射，可以调节肌体功能促进抗体形成，提高人体免疫力。药物穿通皮肤及黏膜后，经过血管或淋巴管进入体循环，也可产生全身性药物作用。因此，越来越多科研人员开始研究通过中医膏药治疗牛皮癣病症。
发明内容
本发明的目的在于提供一种牛皮癣膏药的制备方法，本发明药物所选药材配伍相宜，符合中医药学和现代医药学理论，对治疗牛皮癣引起的各种症状具有显著的效果，疗程短，见效快，疗效可靠，无任何毒副作用，能够达到标本兼治的目的。
为了实现上述目的，本发明提供了一种牛皮癣膏药的制备方法，包括以下步骤：
步骤1、按以下重量份配比称取原料：菊花8-15份、蝉蜕8-15份、丹皮10-20份、蜂蜜15-25份、肉桂10-20份、斑蝥10-20份、肉苁蓉12-14份、瓜络6-12份、大黄6-12份、没药24-28份、草乌13-17份、红丹50-60份、麻油500-600份；
步骤2、将除了红丹和麻油以外的其它原料用100摄氏度流通蒸气加热杀灭微生物的方法，灭菌时间通常为30-60分钟，灭菌干燥后研成100-180目药粉、拌匀、清除杂质；然后放入锅内微火炒黄，待冷却后置于容器内，加入麻油密封浸泡5-7天；
步骤3、将上一步制得物料用小火加热熬制，得熬制物，滤除熬制物中的药渣，得药液；
步骤4、药液中添加红丹，搅拌均匀，熬制成半成品药膏；
步骤5、将上步半成品药膏凉水浸泡1-3天去火毒，然后敷于帆布上，制成膏药。
所述药粉的细度为150目。
所述草乌粉碎研磨前经过预处理，预处理方法如下：将的草乌用水浸泡4-6小时，取出；再用水煮1.5-3个小时，取出，晒20-24小时后切薄片，干燥。
所述蜂蜜粉碎研磨前经过预处理，预处理方法如下：先用武火熬炼蜂蜜20-25分钟后，改为文火缓熬，继续熬制60-70分钟，成条状即可。
所述大黄粉碎研磨前经过预处理，预处理方法如下：将大黄用五十度的白酒侵两小时后，捞出晒干备用。
有益效果：本发明方法制得膏药对于治疗牛皮癣病症具有杀菌止痒、去腐生肌、温中止痛 药效，加快体癣斑片消失和新牛皮癣肌面重生，来快速有效治愈各类牛皮癣。同时本制备方法工艺独到，方法简单，成本低，节能环保，同时能显著缩短生产周期，降低生产成本及能耗，具有显著的竞争优势和广泛的应用前景。
具体实施方式
实施例1
一种牛皮癣膏药的制备方法，包括以下步骤：
步骤1、按以下重量份配比称取原料：菊花8份、蝉蜕8份、丹皮10份、蜂蜜15份、肉桂10份、斑蝥10份、肉苁蓉12份、瓜络6份、大黄6份、没药24份、草乌13份、红丹50份、麻油500份；
步骤2、将除了红丹和麻油以外的其它原料用100摄氏度流通蒸气加热杀灭微生物的方法，灭菌时间通常为30分钟，灭菌干燥后研成100目药粉、拌匀、清除杂质；然后放入锅内微火炒黄，待冷却后置于容器内，加入麻油密封浸泡5-7天；
步骤3、将上一步制得物料用小火加热熬制，得熬制物，滤除熬制物中的药渣，得药液；
步骤4、药液中添加红丹，搅拌均匀，熬制成半成品药膏；
步骤5、将上步半成品药膏凉水浸泡1-3天去火毒，然后敷于帆布上，制成膏药。
其中，步骤2中的药粉的细度为150目。草乌粉碎研磨前经过预处理，预处理方法如下：将的草乌用水浸泡4-6小时，取出；再用水煮1.5-3个小时，取出，晒20-24小时后切薄片，干燥。蜂蜜粉碎研磨前经过预处理，预处理方法如下：先用武火熬炼蜂蜜20-25分钟后，改为文火缓熬，继续熬制60-70分钟，成条状即可。大黄粉碎研磨前经过预处理，预处理方法如下：将大黄用五十度的白酒侵两小时后，捞出晒干备用。
实施例2
一种牛皮癣膏药的制备方法，包括以下步骤：
步骤1、按以下重量份配比称取原料：菊花15份、蝉蜕15份、丹皮20份、蜂蜜25份、肉桂20份、斑蝥20份、肉苁蓉14份、瓜络12份、大黄12份、没药28份、草乌17份、红丹60份、麻油600份；
步骤2、将除了红丹和麻油以外的其它原料用100摄氏度流通蒸气加热杀灭微生物的方法，灭菌时间通常为60分钟，灭菌干燥后研成180目药粉、拌匀、清除杂质；然后放入锅内微火炒黄，待冷却后置于容器内，加入麻油密封浸泡5-7天；
步骤3、将上一步制得物料用小火加热熬制，得熬制物，滤除熬制物中的药渣，得药液；
步骤4、药液中添加红丹，搅拌均匀，熬制成半成品药膏；
步骤5、将上步半成品药膏凉水浸泡1-3天去火毒，然后敷于帆布上，制成膏药。
其中，步骤2中的药粉的细度为150目。草乌粉碎研磨前经过预处理，预处理方法如下：将的草乌用水浸泡4-6小时，取出；再用水煮1.5-3个小时，取出，晒20-24小时后切薄片，干燥。蜂蜜粉碎研磨前经过预处理，预处理方法如下：先用武火熬炼蜂蜜20-25分钟后，改为文火缓熬，继续熬制60-70分钟，成条状即可。大黄粉碎研磨前经过预处理，预处理方法如下：将大黄用五十度的白酒侵两小时后，捞出晒干备用。
实施例3
临床资料：作为治疗牛皮癣的膏药，选择确诊的牛皮癣患者70例临床观察，其中男性40例，女性30例，年龄50-73岁，病程1-6年；将患处洗净擦干，将膏药敷于患处，每日1副，12天为1个疗程，连续使用2-3个疗程。疗效判定：（1）治愈：症状全部消失，身体恢复正常。（2）显效：症状明显减轻，身体明显好转。（3）有效：症状有所减轻，身体有所好转。（4）无效：通过治疗后症状无减轻或加重。由上述临床验证结果可知，用本发明外敷损伤患处，治疗牛皮癣患者70例，取得了较好的临床疗效，治愈64例，显效和有效共6例，有效率达到100%，用药期间未发现局部及全身过敏现象，用药安全。典型病例举例：1、冯某，男，53岁，陕西延安人。患者患有牛皮癣多年，服用药物治疗，服用一段时间后未见任何好转，经朋友介绍来我院就诊，使用本发明膏药1个疗程后，症状明显好转，使用本发明膏药2个疗程后，症状消失，身体恢复正常，一年后随访无复发。
2、陈某，男，58岁，辽宁丹东人。患者自述二十年前患牛皮癣，前期较轻，后发展至俩小腿及头部，多处求医效不显，最近半年来发现鳞屑增多，每天洗头也解决不了鳞屑问题，常见满头鳞屑，稍不注意就会飘落在有颜色的上衣上面，很自卑，羞于见人，多次躲避于该出现的公众场合，尤其是晚上痒的厉害，难以入睡，以期刀割解以痒。使用1个疗程后，患者身体恢复良好，使用本发明膏药2个疗程后，患者自述原症状早已完全消失，日常生活、工作与患病前无异。
Claims (5)
1.一种牛皮癣膏药的制备方法，其特征在于，包括以下步骤：
步骤1、按以下重量份配比称取原料：菊花8-15份、蝉蜕8-15份、丹皮10-20份、蜂蜜15-25份、肉桂10-20份、斑蝥10-20份、肉苁蓉12-14份、瓜络6-12份、大黄6-12份、没药24-28份、草乌13-17份、红丹50-60份、麻油500-600份；
步骤2、将除了红丹和麻油以外的其它原料用100摄氏度流通蒸气加热杀灭微生物的方法，灭菌时间通常为30-60分钟，灭菌干燥后研成100-180目药粉、拌匀、清除杂质；然后放入锅内微火炒黄，待冷却后置于容器内，加入麻油密封浸泡5-7天；
步骤3、将上一步制得物料用小火加热熬制，得熬制物，滤除熬制物中的药渣，得药液；
步骤4、药液中添加红丹，搅拌均匀，熬制成半成品药膏；
步骤5、将上步半成品药膏凉水浸泡1-3天去火毒，然后敷于帆布上，制成膏药。
2.根据权利要求 1所述的一种牛皮癣膏药的制备方法，其特征在于 ：所述药粉的细度为150目。
3.根据权利要求1所述的一种牛皮癣膏药的制备方法，其特征在于 ：所述草乌粉碎研磨前经过预处理，预处理方法如下：将的草乌用水浸泡4-6小时，取出；再用水煮1.5-3个小时，取出，晒20-24小时后切薄片，干燥。
4.根据权利要求1所述的一种牛皮癣膏药的制备方法，其特征在于 ：所述蜂蜜粉碎研磨前经过预处理，预处理方法如下：先用武火熬炼蜂蜜20-25分钟后，改为文火缓熬，继续熬制60-70分钟，成条状即可。
5.根据权利要求1所述的一种牛皮癣膏药的制备方法，其特征在于 ：所述大黄粉碎研磨前经过预处理，预处理方法如下：将大黄用五十度的白酒侵两小时后，捞出晒干备用。
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| CN105853545A (zh) * | 2016-04-29 | 2016-08-17 | 苏州市天灵中药饮片有限公司 | 一种用于治疗牛皮癣外用膏药的制备方法 |
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| CN105832884A (zh) * | 2016-04-29 | 2016-08-10 | 苏州市天灵中药饮片有限公司 | 一种治疗牛皮癣中医膏药的制备方法 |
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| CN105832884A (zh) * | 2016-04-29 | 2016-08-10 | 苏州市天灵中药饮片有限公司 | 一种治疗牛皮癣中医膏药的制备方法 |
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| CN105853545A (zh) * | 2016-04-29 | 2016-08-17 | 苏州市天灵中药饮片有限公司 | 一种用于治疗牛皮癣外用膏药的制备方法 |
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