CN105853016A - Modeling device for mouse with OSAHS (obstructive sleep apnea hypopnea syndrome) - Google Patents
Modeling device for mouse with OSAHS (obstructive sleep apnea hypopnea syndrome) Download PDFInfo
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- CN105853016A CN105853016A CN201610273840.4A CN201610273840A CN105853016A CN 105853016 A CN105853016 A CN 105853016A CN 201610273840 A CN201610273840 A CN 201610273840A CN 105853016 A CN105853016 A CN 105853016A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
- A61D2003/003—Appliances for supporting or fettering animals for operative purposes with head or neck restraining means
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Abstract
The invention discloses a modeling device for a mouse with an OSAHS (obstructive sleep apnea hypopnea syndrome). The modeling device comprises a mouse body container, a head cylinder, an opening and closing mechanism and an air bag, wherein the mouse body container is used for accommodating a mouse body; the head cylinder is used for accommodating the mouse head, and the mouse body container is communicated with the head cylinder; the air bag is located in a position where the mouse body container and the head cylinder are communicated, a through hole allowing penetration of the mouse head is formed in the air bag, and the air bag can locate the mouse neck and block air ventilation between the mouse body container and the head cylinder during inflation; an air hole is formed in one end of the head cylinder, and the opening and closing mechanism is matched with the air hole and used for controlling opening and closing of the air hole. The device can comprehensively stimulate a pathophysiological process of the OSAHS, thereby providing a good animal model for basic research of the OSAHS.
Description
Technical field
The present invention relates to a kind of obstruction sleep apnea-hypopnea syndrome (obstructive sleep
Apnea hypopnea syndrome, OSAHS) laboratory animal mouse model modeling device, the suitableeest
For utilizing rat or the basic research of mice study obstruction sleep apnea-hypopnea syndrome.
Background technology
Obstruction sleep apnea-hypopnea syndrome (OSAHS) sickness rate is high, harm is big, and entirely
The multiple systemic disease of body such as hypertension, coronary heart disease, diabetes, apoplexy etc. is the most closely related.Grind
Studying carefully and think, during the patient sleeps of OSAHS, anoxia, microarousal and sleep deprivation are to cause machine repeatedly
The key factor of body infringement, but its concrete pathogenesis is still not very clear.To this end, people are continuous
Ground the various animal model of research and probe, to analog sleeping apnea patient pathophysiological process such as
Epithelium healing subsides, intermittently anoxia etc., thus furthers investigate the pathogenesis of this disease, finds effective medicine
Thing and other treatment means.In more than 20 year of past, for a certain of OSAHS or certain several respect
Pathophysiology, people have been developed over various types of OSAHS mouse model.
1, natural obstructive sleep apnea animal model
Fat New Zealand mice (NZO) being MRI measure, its internal organs and neck fat increase,
Tongue, soft palate and lateral wall of pharynx are plump.When observing mice sleep, inspiratory airflow lowers.Although but mice is deposited
At airway constriction, but do not occur that genioglossus motion strengthens, and sleep period is (even at REM
Phase) its epithelium healing also keeps stable.This model whether can cause functional airflow obstruction or limited also
Unclear, and non-obese OSAHS can not be simulated.
2, through the obstructive sleep apnea animal model of experiment induction
No matter which kind of laboratory animal, all cannot show the idiopathic obstruction consistent with the mankind completely and breathe
Suspend.Chinese scholars has been invented many OSAHS experimental animal models and has been slept to study mankind's obstructive
Dormancy apnea low syndrome and its shadow to cardiovascular, metabolism, psychology and other health problems
Ring.
2.1 utilize anoxia storehouse to manufacture animal model
The anoxia storehouse set by distinct program, is interrupted under simulation OSAHS patient sleeps's state repeatedly
Property anoxia and this feature of reoxygenation, with inquire into the pathogenesis of OSAHS, pathophysiological process and
Medicament research and development etc..This modeling method is the most commonly used and the most stable, reliable, damages laboratory animal simultaneously
Hinder little, simple and easy to do.
2.1.1 interval hypoxia model
In the last few years, along with the development of technology, interval hypoxia storehouse was constantly improved, the most very
Ripe and easy, as long as rat or mice are put into warehouse, by the concentration of Computer Design hypoxia,
The time of hypoxia and cycle-index etc., it has also become the main method of OSAHS animal model.
Experimental mouse is placed in cabin, alternately injects low oxygen concentration and normal oxygen concentration wherein with the frequency that sets
Gas simulation interval hypoxia, the persistent period is depending on research needs.Application interval hypoxia storehouse is built
Vertical OSAHS model, owing to giving intervening measure by casing, then move putting into casing
For thing, its apneic degree and type do not had particular/special requirement.
It should be noted that the objective feature due to chronic intermittent hypoxia equipment, set anoxia frequency
In rate, minimum oxygen concentration and duration, each research is different.These differences likely there will be disease
The difference of reason physiological process.It is true that mankind OSAHS is a multi-factor disease, at hypoxemia
The degree of disease and the frequency of hypoxia are the most variant.So, although chronic intermittent hypoxia model can generation
Table OSAHS segment pathology physiological process, but must set up a standardization, the chronicest
Disconnected property anoxia model.
2.1.2 interval hypoxia accompanies high CO2Model
OSAHS patient is when Upper airway obstruction, and the most only hypoxia, the most also with hypercapnia.
Therefore, the animal model setting up interval anoxia companion's hypercapnia more meets the Pathophysiology of OSAHS
Situation.Interval hypoxia accompanies high CO2It is similar that warehouse is set up with single batch anoxia storehouse, simply
Many CO2Interface, high pressure CO can be connected2Gas cylinder, and by computer installation CO2Dense
Degree and air inflow.
2.1.3 according to sleep state oxygen-supplying model
Above-mentioned anoxia storehouse does not considers the sleep state of laboratory animal.In view of the hypoxia of OSAHS patient is equal
Sleep occurs, therefore has scholar to develop by computer monitoring, the sleep state that judges animal, only
Supply hypoxia in sleep period, under microarousal and waking state, supply the anoxia storehouse of normal concentration oxygen.
Although this model is closer to clinical OSAHS patient's states, but this device is to single modeling number
There is a definite limitation in amount.And the modeling persistent period by can stable existence sleep analysis monitor signal come
Determine.So, needs are exposed to for a long time to chronic intermittent hypoxia environment sick to study OSAHS
For the research that reason changes, lichen simplex intermittent hypoxia model or the most simple and practical existing modeling
Method.
2.2 the artificial narrow animal model of epithelium healing
Another important feature of OSAHS be epithelium healing subside obstruction and thoracic cavity in negative pressure increase.Therefore,
The intervention of pharyngeal (including oropharynx and glossopharyngeum) is become another the main side setting up OSAHS model
Method and selection.
2.2.1 simulation epithelium healing subsides-reopens the modeling method put
Almendros et al. inserts 2 in experimental rat tracheal strips and intubates, and 1 pipe is placed under trachea
Section, enables animal general breathing, and another Guan Ze is placed in epithelium healing, through a three-way valve respectively
With-a 40cmH2The negative pressure air-suction device of O and a 4cmH2The positive airway pressure device of O is connected,
One conformal face mask communicated with air through electric valve is installed on the nose of rat simultaneously, by closing
Nasal mask valve is also opened negative pressure valve and is made epithelium healing negative pressure subside, by opening nasal mask valve simultaneously
Make epithelium healing reopen with malleation valve to put, so that epithelium healing is in the mode playback that periodically subsides-reopen.
Epithelium healing pressure and nasal mask pressure are monitored in real time, and records air flue flow.When airway pressure is high
In time making the pressure of Airway Collapse, (critical pressure, this experiment is-15cmH2O), nasal pressure and trachea
Pressure is consistent, shows airway open；When airway pressure is less than critical pressure, nasal pressure is not with air flue
Pressure declines, because air flue now subsides.But this model can not simulate long-term OSAHS Pathophysiology
Change.
2.2.2 connect three-way valve by tracheal intubation and make model
Yu-ki Iwasaki et al. is to SD rat circulation of qi promoting every day cannula and connects threeway in tracheal intubation
Pipe, is passed through the isoflurane anesthesia (respirator: tidal volume 2.5ml, respiratory frequency 72 beats/min) of 2%.
Air flue is closed 40 seconds by end-tidal, open airway 80 seconds subsequently, simulate OSAHS 20 times every day.
After OSAHS circulates, blowing air, make rat recover from anesthesia.Recover tube drawing after autonomous respiration.
The method embodies negative pressure in the chronic intermittent hypoxia of OSAHS and thoracic cavity simultaneously, and can continue mould
Intend a period of time, but animal repeatedly intubates and easily causes Accessory injury, need technology that operator is higher and steady
Qualitative.
The pathogenesis of sleep disordered breathing is complicated, and the most still not setting up one can sleep with comprehensive simulated
The animal model of disordered breathing pathophysiological process.From the foregoing, it can be seen that natural obstructive is slept
Dormancy asphyxia animal model can not simulate non-obese OSAHS；Interval hypoxia model only represents
OSAHS segment pathology physiological process, and equipment cost height, order cycle time length, maintenance difficult,
Need to use the relatively hazardous gases such as oxygen；Animal need to be anaesthetized by the artificial narrow animal model of epithelium healing repeatedly,
Can not simulate morbid state for a long time, operation can easily cause Accessory injury, needs the technology that operator is higher
And stability.Therefore, these models have certain limitation.
OSAHS animal model there is no generally acknowledged evaluation criterion at present, mainly sees the animal model of making
Whether it is consistent with mankind's OSAHS genius morbi.Evaluate emphasis specifically includes that the most whether have epithelium healing
Block the sleep apnea and low ventilation caused；The most whether when asphyxia or low ventilation with low
Negative pressure in oxygen mass formed by blood stasis and thoracic cavity；3. can observing and nursing sleep quality analyze obstructing event in sleep and send out
Raw and that brain is electric change；The most whether reproducible OSAHS clinical symptoms.
Summary of the invention
(1) to solve the technical problem that
In view of modeling method of the prior art or its device used in operation or action effect all
There is many defects, it is an object of the invention to provide a kind of brand-new obstructive sleep apnea low pass
Gas syndrome mouse model modeling device, utilizes this device that rat or mice are carried out modeling, it is possible to comprehensively
The pathophysiological process of simulation obstruction sleep apnea-hypopnea syndrome, thus sleep for obstructive
The basic research of dormancy apnea low syndrome provides good animal model.
(2) technical scheme
For solving above-mentioned technical problem, the present invention provides following technical proposals:
A kind of obstruction sleep apnea-hypopnea syndrome mouse model modeling device, holds including Mus body
Device, head cylinder, switching mechanism, air bag；
Described Mus body container is used for accommodating Mus health；
Described head cylinder is used for accommodating Mus head, and described Mus body container connects with described head cylinder；
Described air bag is positioned at the position that described Mus body container is connected with described head cylinder, and described air bag has
Having the through hole passed for Mus head, when described airbag aeration, Mus cervical region can be positioned also by described air bag
Cut off the air circulation between described Mus body container and described head cylinder；
One end of described head cylinder has passage, and described switching mechanism coordinates with described passage, is used for
Control the opening and closing of described passage.
Wherein, described air bag preferably can be fixed on the inside of described Mus body container and be positioned at described Mus
Body container is near one end of described head cylinder.Described air bag is preferably an annular air-pocket, has one in the middle of it
It is available for the through hole that Mus head passes.Described air bag is preferably by outside air delivery device and a breather
Realizing the inflatable and deflatable of air bag, wherein, described breather is placed through described Mus body container near institute
Described air bag and described outside air delivery device are realized connecting by the ventilation pore of the one end stating head cylinder.
Described Mus body container preferably cylindrical shape；Described Mus body container is near one end of described head cylinder relatively
There is ventilation pore goodly.
Described head cylinder is preferably wedge shape tubular, with the head of Mus of preferably fitting.
CO the most also can be installed in described head cylinder2Or O2Concentration detection device, to coordinate experiment to need
Want, CO in detecting head cylinder2Or O2Concentration.
Described head cylinder can be to be flexibly connected with described Mus body container, it is also possible to is one-body molded connection.
When described head cylinder is connected with described Mus body container activities, preferably can connect ring by one and realize institute
State flexible connection.
Described switching mechanism is preferably a cylinder Air-tight piston head, described head cylinder Air-tight piston head and institute
State passage to coordinate, when described head cylinder Air-tight piston head and described passage are fitted, described head cylinder in
Air-tight state, when described head cylinder Air-tight piston head separates with described passage, described head cylinder is ventilation
State；
Described head cylinder Air-tight piston head is preferably controlled mobile by a controller, close to realize described head cylinder
Close the laminating of piston head and described passage and separate.
Described obstruction sleep apnea-hypopnea syndrome mouse model modeling device the most also wraps
Include the thermostat controlling described Mus body container local environment temperature, the preferred tank of described thermostat,
When device works, the water of uniform temperature can be poured in tank, to keep ring residing for Mus body container
The temperature constant state in border.
Described obstruction sleep apnea-hypopnea syndrome mouse model modeling device the most also wraps
Including a base, described base is for installing the Each part of described modeling device.
On the basis of meeting common sense in the field, above-mentioned each optimum condition can combination in any, i.e. get Ben Fa
Bright each preferred embodiments.
(3) beneficial effect
The present invention achieves following beneficial effect:
1, in the present invention, the OSAHS state of simulation can contain chronic intermittent hypoxia and intrathoracic pressure increases
Height, this modeling device being conventional cannot be accomplished；
2, the present invention can monitor OSAHS modeling Mus blood oxygen situation of change at any time, reflects the effective of modeling
Property；
3, the present invention is to modeling experimental mouse without operation Accessory injury, it will not be caused physiological limit bar
Compressing under part, it is not necessary to anesthesia or only calm analog sleeping modeling, persistent period are long, and it is right to be more beneficial for
The research of this kind of chronic disease of OSAHS；
4, the present invention is easy and simple to handle, and equipment volume is little, without the relevant risk such as inflammable and explosive, low cost.
Accompanying drawing explanation
Fig. 1 is the planar structure schematic diagram of modeling device in the embodiment of the present invention 1.
Fig. 2 is the perspective view of modeling device in the embodiment of the present invention 1.
Fig. 3 is that the modeling device setting often circulation of the application present invention causes asphyxia 60 seconds in 90 seconds
Blood oxygen change (A) and the mankind OSAHS patient sleeps of OSAHS model monitor blood oxygen change (B)
Comparison diagram.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearer, below in conjunction with concrete real
Execute example, and referring to the drawings, the present invention is described in further detail.
The present invention provides a kind of obstruction sleep apnea-hypopnea syndrome mouse model modeling device,
Including Mus body container, head cylinder, switching mechanism, air bag；
Described Mus body container is used for accommodating Mus health；
Described head cylinder is used for accommodating Mus head, and described Mus body container connects with described head cylinder；
Described air bag is positioned at the position that described Mus body container is connected with described head cylinder, and described air bag has
Having the through hole passed for Mus head, when described airbag aeration, Mus cervical region can be positioned also by described air bag
Cut off the air circulation between described Mus body container and described head cylinder；
One end of described head cylinder has passage, and described switching mechanism coordinates with described passage, is used for
Control the opening and closing of described passage.
The present invention one preferred embodiment in, described air bag is the air bag of an endless belt through hole, its
It is fixed on the inside of described Mus body container and is positioned at described Mus body container near one end of described head cylinder, should
Air bag is available for Mus head and passes, and when airbag aeration, is positioned by Mus cervical region and cut off described Mus body and hold
Air circulation between device and described head cylinder.Described air bag is by outside air delivery device and a breather
Realizing the inflatable and deflatable of air bag, wherein, described breather is placed through described Mus body container near institute
Described air bag and described outside air delivery device are realized connecting by the ventilation pore of the one end stating head cylinder.
Described Mus body container is placed in a tank, and this tank can pour into warm water and keep the perseverance of Mus body container
Temperature.The Each part of device is installed on a base, to be convenient for carrying and to manipulate.
In another preferred implementation of the present invention, described switching mechanism is a cylinder Air-tight piston head,
Described head cylinder Air-tight piston head coordinates with described passage, when described head cylinder Air-tight piston head is logical with described
During pore laminating, described head cylinder is air-tight state, when described head cylinder Air-tight piston head and described passage
Time separately, described head cylinder is aeration status.Described head cylinder Air-tight piston head is controlled mobile by a controller,
To realize the laminating of described head cylinder Air-tight piston head and described passage and to separate.Described controller includes
One control panel, it connects power supply by power line, described control panel can set head cylinder airtight
Piston head and head cylinder Guan Bi and open time cyclic program, the unit of time that can set includes: the second,
0.1 minute, minute and hour, experimenter can be the most specifically chosen.
In the further embodiment of the present invention, described Mus body container is with described head cylinder by one even
T-Ring realizes connecting, and described Mus body container has bayonet socket near one end of described head cylinder, by by screw
Through connecting ring described in the further clamping of described bayonet socket, it is achieved described Mus body container and the jail of described head cylinder
It is solidly connected.
Specific embodiment is presented herein below, special for further describing the structure of apparatus of the present invention in detail
Point, operation principle and technique effect.
Embodiment 1
As depicted in figs. 1 and 2, the obstruction sleep apnea-hypopnea syndrome Mus of the present embodiment
Model modeling device, including Mus body container 3, head cylinder 9, connect ring 7, switching mechanism, air bag 4,
Controller 15；
Described Mus body container 3 is used for accommodating Mus health；
Described head cylinder 9 is used for accommodating Mus head, and described Mus body container 3 is by connecting ring 7 and described head
Cylinder 9 connection；Described Mus body container 3 has bayonet socket 6 near one end of described head cylinder 9, by by spiral shell
Follow closely through connection ring 7 described in the described further clamping of bayonet socket 6, it is achieved described Mus body container 3 and described
The firm connection of head cylinder 9.
Described air bag 4 is positioned at the position that described Mus body container 3 is connected with described head cylinder 9, described
Air bag 4 has the through hole passed for Mus head, and when described air bag 4 is inflated, described air bag 4 can be by
The air circulation that Mus cervical region positions and cuts off between described Mus body container 3 and described head cylinder 9；Described gas
Capsule 4 realizes the inflatable and deflatable of air bag 4 by an inflating ball 8 and a breather 5, wherein, described
Breather 5 is placed through the described Mus body container 3 ventilation pore near one end of described head cylinder 9 by institute
State air bag 4 and described inflating ball 8 realizes connecting.
One end of described head cylinder 9 has passage, and described switching mechanism coordinates with described passage, uses
In the opening and closing controlling described passage.
Described switching mechanism is a cylinder Air-tight piston head 10, described head cylinder Air-tight piston head 10 and institute
State passage to coordinate, when described head cylinder Air-tight piston head 10 is fitted with described passage, described head
Cylinder 9 is in air-tight state, when described head cylinder Air-tight piston head 10 separates with described passage, described
Head cylinder 9 is in aeration status.Described head cylinder Air-tight piston head 10 is controlled mobile by a controller 15, with
Realize the laminating of described head cylinder Air-tight piston head 10 and described passage and separate.
When practical operation, in the control panel 21 of controller 15, first set described head cylinder airtight
Piston head 10 airtight head cylinder 9 and the time cyclic program of open head cylinder 9, unit of time includes: the second,
0.1 minute, minute and hour.Mus body container 3, connection ring 7, air bag 4, head cylinder 9 are connected,
It is placed in a tank 2, is then put on the Mus body container draw-in groove of base 1, Mus is held as Mus body
Device 3 rear portion, Mus will pierce in Mus body container 3 voluntarily, and Mus head enters head cylinder 9, extrude inflating ball 8,
By breather 5 to air bag 4 gas injection, Mus head is fixed in head cylinder 9 and with Mus body container 3 air
Isolation, front and back adjusts head cylinder 9 position and fits with Mus head.Tank 2 injects preference temperature water.Pass through
Data wire 14 connects controller 15 and head cylinder Air-tight piston head 10, and power line 16 connects power supply, electricity
The plug 17 that source line 16 band switches on power.Opening switch 19 can be logical according to the cyclic program set
Cross data line interface 13 and receive program singal, complete piston impeller-hub 12 and drive piston rod 11 reciprocal
Motion, make head cylinder Air-tight piston head 10 and the blow vent on head cylinder 9 complete to close by cyclic program and
Opening Ventilation hole, completes to simulate the model that Mus cogwheel breathing repeatedly suspends.The display screen of controller 15
20 can show the real-time time in circulation every time, can suspend cyclic program at any time by Pause key 18.
As it is shown on figure 3, the modeling device that it is the application present invention sets often circulation within 90 seconds, causes breathing
Blood oxygen change (A) of the OSAHS model suspending 60 seconds is monitored with mankind OSAHS patient sleeps
The comparison diagram of blood oxygen change (B).It can be seen that this modeling device can replicate OSAHS completely
The blood oxygen change that asphyxia repeatedly under state causes.Meanwhile, by the chest and abdomen of Mus during asphyxia
Dyskinesis, it is achieved that intrathoracic pressure repeatedly under OSAHS state.After noinvasive modeling, Mus is healthy
In order, it is not caused the compressing under the conditions of any physiological limit by whole process.
Particular embodiments described above, is carried out the purpose of the present invention, technical scheme and beneficial effect
Further describe it should be understood that the foregoing is only the specific embodiment of the present invention,
Be not limited to the present invention, all within the spirit and principles in the present invention, any amendment of being made,
Equivalent, improvement etc., should be included within the scope of the present invention.
Claims (12)
1. an obstruction sleep apnea-hypopnea syndrome mouse model modeling device, its feature
It is, including Mus body container, head cylinder, switching mechanism, air bag；
Described Mus body container is used for accommodating Mus health；
Described head cylinder is used for accommodating Mus head, and described Mus body container connects with described head cylinder；
Described air bag is positioned at the position that described Mus body container is connected with described head cylinder, and described air bag has
Having the through hole passed for Mus head, when described airbag aeration, Mus cervical region can be positioned also by described air bag
Cut off the air circulation between described Mus body container and described head cylinder；
One end of described head cylinder has passage, and described switching mechanism coordinates with described passage, is used for
Control the opening and closing of described passage.
Obstruction sleep apnea-hypopnea syndrome mouse model the most according to claim 1
Modeling device, it is characterised in that described air bag is fixed on the inside of described Mus body container and is positioned at described
Mus body container is near one end of described head cylinder.
Obstruction sleep apnea-hypopnea syndrome mouse model the most according to claim 1
Modeling device, it is characterised in that described air bag is an annular air-pocket, has one for Mus head in the middle of it
The through hole passed.
Obstruction sleep apnea-hypopnea syndrome mouse model the most according to claim 1
Modeling device, it is characterised in that described air bag is connected by the outside air delivery device of a breather and,
To realize the inflatable and deflatable of air bag, wherein, to be placed through described Mus body container close for described breather
The ventilation pore of one end of described head cylinder.
Obstruction sleep apnea-hypopnea syndrome mouse model the most according to claim 1
Modeling device, it is characterised in that described Mus body container is cylindric.
Obstruction sleep apnea-hypopnea syndrome mouse model the most according to claim 1
Modeling device, it is characterised in that described head cylinder is wedge shape tubular.
Obstruction sleep apnea-hypopnea syndrome mouse model the most according to claim 1
Modeling device, it is characterised in that install CO in described head cylinder2Or O2Concentration detection device.
Obstruction sleep apnea-hypopnea syndrome mouse model the most according to claim 1
Modeling device, it is characterised in that described head cylinder is connected or one-body molded company with described Mus body container activities
Connect.
Obstruction sleep apnea-hypopnea syndrome mouse model the most according to claim 8
Modeling device, it is characterised in that when described head cylinder is connected with described Mus body container activities, by one
Connect ring and realize described flexible connection.
Obstruction sleep apnea-hypopnea syndrome mouse model the most according to claim 1
Modeling device, it is characterised in that described switching mechanism is a cylinder Air-tight piston head, and described head cylinder is close
Close piston head to coordinate with described passage, when described head cylinder Air-tight piston head is fitted with described passage,
Described head cylinder is air-tight state, when described head cylinder Air-tight piston head separates with described passage, described
Head cylinder is aeration status；
Described head cylinder Air-tight piston head is controlled mobile, to realize described head cylinder Air-tight piston by a controller
Head and the laminating of described passage with separate.
11. obstruction sleep apnea-hypopnea syndrome mouse models according to claim 1
Modeling device, it is characterised in that also include the constant temperature dress controlling described Mus body container local environment temperature
Putting, the preferred tank of described thermostat, described tank is around described Mus body container.
12. obstruction sleep apnea-hypopnea syndrome mouse models according to claim 1
Modeling device, it is characterised in that also include that a base, described base are used for installing described modeling device
Each part.
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