CN101491477A - Animal experiment device capable of providing intermittence low-oxygen environment - Google Patents
Animal experiment device capable of providing intermittence low-oxygen environment Download PDFInfo
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- CN101491477A CN101491477A CNA2009100795794A CN200910079579A CN101491477A CN 101491477 A CN101491477 A CN 101491477A CN A2009100795794 A CNA2009100795794 A CN A2009100795794A CN 200910079579 A CN200910079579 A CN 200910079579A CN 101491477 A CN101491477 A CN 101491477A
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Abstract
The invention provides an animal experimental device used for providing an intermittent hypoxia environment. The device comprises an air controlling device and a breeding cabin, wherein an oxygen controlling electromagnetic valve (1), an air exhaust controlling electromagnetic valve (2) and a nitrogen controlling electromagnetic valve (3) of the air controlling device are provided with an air inlet and an air outlet respectively; the oxygen controlling electromagnetic valve (1) is electrically connected with an oxygen circulation control timer (4) to form an oxygen controlling unit; the nitrogen controlling electromagnetic valve (3) is electrically connected with a nitrogen circulation control timer (7) to form a nitrogen controlling unit; the oxygen controlling unit and the nitrogen controlling unit are connected in parallel and connected to a DC power supply (15); the air exhaust controlling electromagnetic valve (2) is connected with a rectifying diode and then connected to the oxygen controlling unit and the nitrogen controlling unit respectively; the breeding cabin is provided with an oxygen inlet, a nitrogen inlet and an air vent; the oxygen inlet is communicated with the air outlet of the oxygen controlling electromagnetic valve (1); the nitrogen inlet is communicated with the air outlet of the nitrogen controlling electromagnetic valve (3); and the air vent is communicated with the air inlet of the an air exhaust controlling electromagnetic valve. The device can be well applied to simulative experiments of sleep apnea.
Description
Technical field
The present invention relates to a kind of animal experiment device capable that intermittence low-oxygen environment is provided.
Background technology
The research of sleep apnea disease need provide the animal experiment device capable that intermittence low-oxygen environment can be provided for laboratory animal, simulates sleep apnea hypoxia and reoxygenation repeatedly.Described reoxygenation is a meaning of recovering oxygen concentration.Existing this type of device just simple substitution is supplied with oxygen and nitrogen and is reached repeatedly hypoxia and reoxygenation, can not guarantee that feeding cabin is in atmospheric pressure state, can not realize the accurate control of oxygen concentration and cycle rate, can overcome above-mentioned defective so be necessary to provide a kind of, preferably the animal experiment device capable that intermittence low-oxygen environment is provided of lower, simple in structure, the easy operating of cost.
Summary of the invention
The invention provides a kind of animal experiment device capable that intermittence low-oxygen environment is provided that can satisfy above-mentioned needs.
The animal experiment device capable that intermittence low-oxygen environment is provided of the present invention, comprise gas control equipment and feeding cabin, it is characterized in that: described gas control equipment comprises oxygen control electromagnetic valve, aerofluxus control electromagnetic valve, nitrogen control electromagnetic valve, oxygen loop control intervalometer, nitrogen circulation control timer and dc source, oxygen control electromagnetic valve, aerofluxus control electromagnetic valve, nitrogen control electromagnetic valve has air inlet and gas outlet respectively, oxygen control electromagnetic valve and the oxygen loop control intervalometer oxygen control unit that is electrically connected to form, nitrogen control electromagnetic valve and the nitrogen circulation control timer nitrogen control unit that is electrically connected to form, described oxygen control unit and described nitrogen control unit access in parallel dc source; After connecting a commutation diode respectively, aerofluxus control electromagnetic valve inserts described oxygen control unit and described nitrogen control unit; Described feeding cabin has oxygen intake, nitrogen inlet and air vent; Oxygen intake is communicated with the gas outlet of oxygen control electromagnetic valve, and nitrogen inlet is communicated with the gas outlet of nitrogen control electromagnetic valve, and air vent is communicated with the air inlet of gas exhausting valve.
Described oxygen control unit and described nitrogen control unit and feeding cabin can be many groups.
Oxygen control electromagnetic valve, aerofluxus control electromagnetic valve and the air inlet of nitrogen control electromagnetic valve and oxygen intake, nitrogen inlet and the air vent of gas outlet and described feeding cabin preferably all have identical aperture.
Preferably, described feeding cabin is provided with the oxygen concentration alarm probe, and oxygen intake and nitrogen inlet are provided with acoustic filter.
Preferably, the rectangular box body of described feeding cabin for being made of poly (methyl methacrylate) plate is provided with end box, action pane and porous interlayer board in the described feeding cabin.The thickness of described lucite is preferably 0.5-2 centimetre.
Described gas control equipment can also comprise the oxygen delivery display lamp that inserts described oxygen control unit, nitrogen conveying display lamp and the on and off switch that inserts described nitrogen control unit.
The animal experiment device capable that intermittence low-oxygen environment is provided of the present invention, supply with by the circulation of oxygen loop control intervalometer and nitrogen circulation control timer control oxygen and nitrogen respectively, realize altofrequency hypoxia and the living environment of reoxygenation laboratory repeatedly, the aerofluxus control electromagnetic valve that inserts makes the air pressure in the feeding cabin be in atmospheric pressure state under the control of oxygen loop control intervalometer and nitrogen circulation control timer always, the animal experiment device capable that intermittence low-oxygen environment is provided of the present invention simple in structure is convenient to experimental implementation.
Description of drawings
Fig. 1 is the structural representation of the gas control equipment of the animal experiment device capable that intermittence low-oxygen environment is provided of the present invention;
Fig. 2 is the structural representation of the feeding cabin of the animal experiment device capable that intermittence low-oxygen environment is provided of the present invention;
Fig. 3 is the circuit diagram of the gas control equipment of the animal experiment device capable that intermittence low-oxygen environment is provided of the present invention.
Among the figure: 1-oxygen control electromagnetic valve, 2-aerofluxus control electromagnetic valve, 3-nitrogen control electromagnetic valve, 4-oxygen loop control intervalometer, 5-oxygen delivery display lamp, 6-on and off switch, 7-nitrogen circulation control timer, 8-nitrogen is carried display lamp, 9-oxygen intake, the 10-nitrogen inlet, the 11-air vent, box at the bottom of the 12-, 13-action pane, 14-porous interlayer board, the 15-dc source.
The specific embodiment
Below by the specific embodiment the present invention is described further.
The animal experiment device capable of intermittence low-oxygen environment that provides of the present invention comprises gas control equipment and feeding cabin.As shown in Figure 1, described gas control equipment comprises oxygen control electromagnetic valve 1, aerofluxus control electromagnetic valve 2, nitrogen control electromagnetic valve 3, oxygen loop control intervalometer 4, nitrogen circulation control timer 7, and oxygen control electromagnetic valve 1, aerofluxus control electromagnetic valve 2, nitrogen control electromagnetic valve 3 have air inlet and gas outlet respectively.Described gas control equipment also comprises the oxygen delivery display lamp 5 that inserts described oxygen control unit, nitrogen conveying display lamp 8 and the on and off switch 6 that inserts described nitrogen control unit.
As shown in Figure 3, oxygen control electromagnetic valve 1 and the oxygen loop control intervalometer 4 oxygen control unit that is electrically connected to form, nitrogen control electromagnetic valve 3 and the nitrogen circulation control timer 7 nitrogen control unit that is electrically connected to form, described oxygen control unit and the described nitrogen control unit dc source 15 that inserts in parallel; Insert described oxygen control unit and described nitrogen control unit after aerofluxus control electromagnetic valve 2 connects a commutation diode respectively, be subjected to oxygen loop control intervalometer 4 and 7 controls of nitrogen circulation control timer.
The described feeding cabin rectangular box body that the poly (methyl methacrylate) plate of about 1 cm thick constitutes of serving as reasons, as shown in Figure 2, described feeding cabin has oxygen intake 9, nitrogen inlet 10 and air vent 11, is provided with end box 12, action pane 13 and porous interlayer board 14 in the described feeding cabin.
The air inlet and the gas outlet of oxygen control electromagnetic valve 1, aerofluxus control electromagnetic valve 2, nitrogen control electromagnetic valve 3, and the oxygen intake 9 of described feeding cabin, nitrogen inlet 10 and air vent 11 all have identical aperture.Oxygen intake 9 is communicated with the gas outlet of oxygen control electromagnetic valve 1, and nitrogen inlet 10 is communicated with the gas outlet of nitrogen control electromagnetic valve 3, and air vent 11 is communicated with the air inlet of gas exhausting valve.Described feeding cabin is provided with the oxygen concentration alarm probe, and oxygen intake 9 and nitrogen inlet 10 are provided with acoustic filter, and installation also is equipped with small fan in the cabin, and foregoing is readily appreciated that, does not therefore represent with accompanying drawing.
Below by concrete mode of operation the present invention is described further.
At first regulate the working time of cycle timer, oxygen loop control intervalometer 4 and nitrogen circulation control timer 7 all are the two setting-up time timers of ZN86 intelligence, regulate the intermittent time 50s of oxygen loop control intervalometer 4, and the working time is 10s; The working time of regulating nitrogen circulation control timer 7 is 20s, and the intermittent time is 40s; Aerofluxus control electromagnetic valve 2 is opened when oxygen control electromagnetic valve 1 is opened, and aerofluxus control electromagnetic valve 2 was also opened when nitrogen control electromagnetic valve 3 was opened.The back powered-down is set more than the affirmation.
Experimental mouse is put into feeding cabin, open oxygen and nitrogen current scale (SH-2 type) respectively, regulate flow, turn on the power switch 6, this moment, nitrogen control electromagnetic valve 3 and aerofluxus control electromagnetic valve 2 were opened, and input nitrogen makes oxygen concentration decline in the cabin in the cabin; Nitrogen control electromagnetic valve 3 and aerofluxus control electromagnetic valve 2 are closed automatically behind the 40s, keep low-oxygen environment 10s in the cabin; Then oxygen control electromagnetic valve 1 and aerofluxus control electromagnetic valve 2 are opened automatically, and input oxygen makes that oxygen concentration returns to normal level in the cabin in the cabin, closes automatically behind the 10s.So automatically switch, reach in the cabin hypoxia and reoxygenation environment repeatedly.The deafener of oxygen intake 9 and nitrogen inlet setting can reduce the gas quick high-pressure and enter sound in the cabin.Small fan is installed in the cabin, can be made the quick mixing of the gas that enters in the cabin, experimental mouse is in the oxygen concentration environment of homogeneous in the assurance cabin.
The feeding cabin sidewall has an aperture, and oxygen concentration alarm probe (DYB-7200 type hypoxia alarm) is installed, and the oxygen concentration alarm threshold value is set, when oxygen concentration in the cabin is crossed when low or too high, the warning of can blowing a whistle, the scientific research personnel is reaction treatment in time, prevents that experimental mouse from meeting accident.
The purpose of porous interlayer board 14 is to keep the laboratory animal environment with the excretory urine of experimental mouse and feces every omitting in printing in chassis 12 in the cabin; Also can deposit desiccant and sodica calx in the chassis 12, absorb the water vapour and the CO2 that discharge, chassis 12 can be extracted out, is convenient to clean and change medicine.For guaranteeing the seal of feeding cabin, airtight good hatch door has been installed in action pane 13 outsides.
Should be understood that, more than describe only to be in and illustrate purpose, can also carry out many changes and improvements, for example: described oxygen control unit and described nitrogen control unit also can be many groups, thereby connect a plurality of feeding cabins, the concrete structure of gas control equipment and feeding cabin also can be done suitable improvement.These changes and improvements are all within protection scope of the present invention.
Claims (6)
1, a kind of animal experiment device capable that intermittence low-oxygen environment is provided, comprise gas control equipment and feeding cabin, it is characterized in that: described gas control equipment comprises oxygen control electromagnetic valve (1), aerofluxus control electromagnetic valve (2), nitrogen control electromagnetic valve (3), oxygen loop control intervalometer (4), nitrogen circulation control timer (7) and dc source (15), oxygen control electromagnetic valve (1), aerofluxus control electromagnetic valve (2), nitrogen control electromagnetic valve (3) has air inlet and gas outlet respectively, oxygen control electromagnetic valve (1) and oxygen loop control intervalometer (4) the oxygen control unit that is electrically connected to form, nitrogen control electromagnetic valve (3) and nitrogen circulation control timer (7) the nitrogen control unit that is electrically connected to form, described oxygen control unit and the described nitrogen control unit dc source (15) that inserts in parallel; Aerofluxus control electromagnetic valve (2) inserts described oxygen control unit and described nitrogen control unit after connecting a commutation diode respectively; Described feeding cabin has oxygen intake (9), nitrogen inlet (10) and air vent (11); Oxygen intake (9) is communicated with the gas outlet of oxygen control electromagnetic valve (1), and nitrogen inlet (10) is communicated with the gas outlet of nitrogen control electromagnetic valve (3), and air vent (11) is communicated with the air inlet of gas exhausting valve.
2, the animal experiment device capable that intermittence low-oxygen environment is provided according to claim 1 is characterized in that: oxygen control electromagnetic valve (1), aerofluxus control electromagnetic valve (2) all have identical aperture with the air inlet of nitrogen control electromagnetic valve (3) and oxygen intake (9), nitrogen inlet (10) and the air vent (11) of gas outlet and described feeding cabin.
3, the animal experiment device capable that intermittence low-oxygen environment is provided according to claim 1, it is characterized in that: described feeding cabin is provided with the oxygen concentration alarm probe, and oxygen intake (9) and nitrogen inlet (10) are provided with acoustic filter.
4, the animal experiment device capable that intermittence low-oxygen environment is provided according to claim 1, it is characterized in that: the rectangular box body of described feeding cabin for being made of poly (methyl methacrylate) plate is provided with end box (12), action pane (13) and porous interlayer board (14) in the described feeding cabin.
5, the animal experiment device capable that intermittence low-oxygen environment is provided according to claim 1 is characterized in that: the thickness of described lucite is 0.5-2 centimetre.
6, the animal experiment device capable that intermittence low-oxygen environment is provided according to claim 1 is characterized in that: described gas control equipment also comprises the oxygen delivery display lamp (5) that inserts described oxygen control unit, nitrogen conveying display lamp (8) and the on and off switch (6) that inserts described nitrogen control unit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNA2009100795794A CN101491477A (en) | 2009-03-10 | 2009-03-10 | Animal experiment device capable of providing intermittence low-oxygen environment |
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| CNA2009100795794A CN101491477A (en) | 2009-03-10 | 2009-03-10 | Animal experiment device capable of providing intermittence low-oxygen environment |
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| CN101491477A true CN101491477A (en) | 2009-07-29 |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198321A (en) * | 2011-03-17 | 2011-09-28 | 中国人民解放军空军航空医学研究所 | Normal-pressure hypoxic cabin for interval hypoxic training and method for regulating oxygen concentration in hypoxic cabin |
| CN102217552A (en) * | 2011-04-26 | 2011-10-19 | 广州医学院第一附属医院 | Full-automatic hypoxic animal model breeding box |
| CN102484982A (en) * | 2010-12-06 | 2012-06-06 | 西安市第一医院 | Oxygen concentration controllable mouse rearing box |
| CN103263301A (en) * | 2013-06-21 | 2013-08-28 | 天津开发区合普工贸有限公司 | Controllable microenvironment flowing gas animal experiment cabin |
| CN105662753A (en) * | 2016-01-12 | 2016-06-15 | 中国人民解放军军事医学科学院基础医学研究所 | Intermittent hypoxia method and application thereof in aspect of improving cognitive function |
| CN105853016A (en) * | 2016-04-28 | 2016-08-17 | 首都医科大学附属北京安贞医院 | Modeling device for mouse with OSAHS (obstructive sleep apnea hypopnea syndrome) |
| CN106137643A (en) * | 2016-08-11 | 2016-11-23 | 北京众实迪创科技发展有限责任公司 | Zoopery high-low pressure oxygen storehouse |
| GB2547022A (en) * | 2016-02-05 | 2017-08-09 | Univ Of Zargreb School Of Medicine | An automated system for inducing hypoxia |
| CN107811262A (en) * | 2017-12-06 | 2018-03-20 | 宁夏红山河食品股份有限公司 | A kind of preparation method and application of bioactivity barbecue sauce |
| CN107822079A (en) * | 2017-12-06 | 2018-03-23 | 宁夏红山河食品股份有限公司 | A kind of preparation method and application of small peptide barbecue sauce |
| CN107865377A (en) * | 2017-12-06 | 2018-04-03 | 宁夏红山河食品股份有限公司 | A kind of microcapsules barbecue sauce and preparation method and application |
| CN113040971A (en) * | 2021-05-10 | 2021-06-29 | 深圳市鑫试科技有限公司 | Animal modeling system for obstructive sleep apnea syndrome |
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102484982A (en) * | 2010-12-06 | 2012-06-06 | 西安市第一医院 | Oxygen concentration controllable mouse rearing box |
| CN102198321A (en) * | 2011-03-17 | 2011-09-28 | 中国人民解放军空军航空医学研究所 | Normal-pressure hypoxic cabin for interval hypoxic training and method for regulating oxygen concentration in hypoxic cabin |
| CN102198321B (en) * | 2011-03-17 | 2013-07-31 | 中国人民解放军空军航空医学研究所 | Normal-pressure hypoxic cabin for interval hypoxic training and method for regulating oxygen concentration in hypoxic cabin |
| CN102217552A (en) * | 2011-04-26 | 2011-10-19 | 广州医学院第一附属医院 | Full-automatic hypoxic animal model breeding box |
| CN103263301A (en) * | 2013-06-21 | 2013-08-28 | 天津开发区合普工贸有限公司 | Controllable microenvironment flowing gas animal experiment cabin |
| CN105662753A (en) * | 2016-01-12 | 2016-06-15 | 中国人民解放军军事医学科学院基础医学研究所 | Intermittent hypoxia method and application thereof in aspect of improving cognitive function |
| GB2547022A (en) * | 2016-02-05 | 2017-08-09 | Univ Of Zargreb School Of Medicine | An automated system for inducing hypoxia |
| GB2547022B (en) * | 2016-02-05 | 2019-10-02 | Univ Of Zagreb | An automated system for inducing hypoxia |
| CN105853016B (en) * | 2016-04-28 | 2017-06-27 | 首都医科大学附属北京安贞医院 | Obstruction sleep apnea-hypopnea syndrome mouse model modeling device |
| CN105853016A (en) * | 2016-04-28 | 2016-08-17 | 首都医科大学附属北京安贞医院 | Modeling device for mouse with OSAHS (obstructive sleep apnea hypopnea syndrome) |
| CN106137643A (en) * | 2016-08-11 | 2016-11-23 | 北京众实迪创科技发展有限责任公司 | Zoopery high-low pressure oxygen storehouse |
| CN107811262A (en) * | 2017-12-06 | 2018-03-20 | 宁夏红山河食品股份有限公司 | A kind of preparation method and application of bioactivity barbecue sauce |
| CN107822079A (en) * | 2017-12-06 | 2018-03-23 | 宁夏红山河食品股份有限公司 | A kind of preparation method and application of small peptide barbecue sauce |
| CN107865377A (en) * | 2017-12-06 | 2018-04-03 | 宁夏红山河食品股份有限公司 | A kind of microcapsules barbecue sauce and preparation method and application |
| CN113040971A (en) * | 2021-05-10 | 2021-06-29 | 深圳市鑫试科技有限公司 | Animal modeling system for obstructive sleep apnea syndrome |
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| C06 | Publication | ||
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| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Luo Qin Inventor after: Liu Zhihong Inventor after: Zhao Zhihui Inventor after: Zhang Hongliang Inventor after: Wang Yong Inventor after: Zhao Qing Inventor after: An Ruiming Inventor before: Luo Qin Inventor before: Liu Zhihong Inventor before: Zhang Hongliang Inventor before: Wang Yong Inventor before: An Ruiming |
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Free format text: CORRECT: INVENTOR; FROM: LUO QIN LIU ZHIHONG ZHANG HONGLIANG WANG YONG AN RUIMING TO: LUO QIN LIU ZHIHONG ZHAO ZHIHUI ZHANG HONGLIANG WANG YONG ZHAO QING AN RUIMING |
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Application publication date: 20090729 |