CN201366050Y - Animal experiment device for providing intermittent hypoxia environment - Google Patents
Animal experiment device for providing intermittent hypoxia environment Download PDFInfo
- Publication number
- CN201366050Y CN201366050Y CNU2009201063708U CN200920106370U CN201366050Y CN 201366050 Y CN201366050 Y CN 201366050Y CN U2009201063708 U CNU2009201063708 U CN U2009201063708U CN 200920106370 U CN200920106370 U CN 200920106370U CN 201366050 Y CN201366050 Y CN 201366050Y
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- China
- Prior art keywords
- oxygen
- nitrogen
- control
- electromagnetic valve
- control unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 241001465754 Metazoa Species 0.000 title claims abstract description 23
- 206010021143 Hypoxia Diseases 0.000 title abstract description 7
- 230000007954 hypoxia Effects 0.000 title abstract description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 146
- 239000001301 oxygen Substances 0.000 claims abstract description 105
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 105
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 82
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 75
- 239000007789 gas Substances 0.000 claims abstract description 36
- 239000011229 interlayer Substances 0.000 claims description 5
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 5
- 239000000523 sample Substances 0.000 claims description 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 3
- 229920005479 Lucite® Polymers 0.000 claims description 2
- 201000002859 sleep apnea Diseases 0.000 abstract description 3
- 238000004172 nitrogen cycle Methods 0.000 abstract 1
- 238000004088 simulation Methods 0.000 abstract 1
- 238000010171 animal model Methods 0.000 description 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Abstract
The utility model provides an animal experiment device for providing the intermittent hypoxia environment, which comprises a gas control unit and a feeding cabin, wherein an oxygen control solenoid valve (1), an exhaust control solenoid valve (2) and a nitrogen control solenoid valve (3) of the gas control unit are respectively provided with gas inlets and gas outlets; the oxygen control solenoid valve (1) is electrically connected with an oxygen cycle control timer (4) to form an oxygen control unit; the nitrogen control solenoid valve (3) is electrically connected with a nitrogen cycle control timer (7) to form a nitrogen control unit; the oxygen control unit and the nitrogen control unit are connected in parallel with a DC power supply (15); the exhaust control solenoid valve (2) is respectively connected with a rectifier diode and then is connected with the oxygen control unit and the nitrogen control unit; the feeding cabin is provided with an oxygen inlet, a nitrogen inlet and an exhaust port; the oxygen inlet is communicated with the gas outlet of the oxygen control solenoid valve (1); the nitrogen inlet is communicated with the gas outlet of the nitrogen control solenoid valve (3); and the exhaust port is communicated with the gas inlet of the exhaust control valve. The animal experiment device can be better applicable to simulation experiments of sleep apnea.
Description
Technical field
This utility model relates to a kind of animal experiment device capable that intermittence low-oxygen environment is provided.
Background technology
The research of sleep apnea disease need provide the animal experiment device capable that intermittence low-oxygen environment can be provided for laboratory animal, simulates sleep apnea hypoxia and reoxygenation repeatedly.Described reoxygenation is a meaning of recovering oxygen concentration.Existing this type of device just simple substitution is supplied with oxygen and nitrogen and is reached repeatedly hypoxia and reoxygenation, can not guarantee that feeding cabin is in atmospheric pressure state, can not realize the accurate control of oxygen concentration and cycle rate, can overcome above-mentioned defective so be necessary to provide a kind of, preferably the animal experiment device capable that intermittence low-oxygen environment is provided of lower, simple in structure, the easy operating of cost.
The utility model content
This utility model provides a kind of animal experiment device capable that intermittence low-oxygen environment is provided that can satisfy above-mentioned needs.
The animal experiment device capable that intermittence low-oxygen environment is provided of the present utility model, comprise gas control equipment and feeding cabin, it is characterized in that: described gas control equipment comprises oxygen control electromagnetic valve, aerofluxus control electromagnetic valve, nitrogen control electromagnetic valve, oxygen loop control intervalometer, nitrogen circulation control timer and dc source, oxygen control electromagnetic valve, aerofluxus control electromagnetic valve, nitrogen control electromagnetic valve has air inlet and gas outlet respectively, oxygen control electromagnetic valve and the oxygen loop control intervalometer oxygen control unit that is electrically connected to form, nitrogen control electromagnetic valve and the nitrogen circulation control timer nitrogen control unit that is electrically connected to form, described oxygen control unit and described nitrogen control unit access in parallel dc source; After connecting a commutation diode respectively, aerofluxus control electromagnetic valve inserts described oxygen control unit and described nitrogen control unit; Described feeding cabin has oxygen intake, nitrogen inlet and air vent; Oxygen intake is communicated with the gas outlet of oxygen control electromagnetic valve, and nitrogen inlet is communicated with the gas outlet of nitrogen control electromagnetic valve, and air vent is communicated with the air inlet of gas exhausting valve.
Described oxygen control unit and described nitrogen control unit and feeding cabin can be many groups.
Oxygen control electromagnetic valve, aerofluxus control electromagnetic valve and the air inlet of nitrogen control electromagnetic valve and oxygen intake, nitrogen inlet and the air vent of gas outlet and described feeding cabin preferably all have identical aperture.
Preferably, described feeding cabin is provided with the oxygen concentration alarm probe, and oxygen intake and nitrogen inlet are provided with acoustic filter.
Preferably, the rectangular box body of described feeding cabin for being made of poly (methyl methacrylate) plate is provided with end box, action pane and porous interlayer board in the described feeding cabin.The thickness of described lucite is preferably 0.5-2 centimetre.
Described gas control equipment can also comprise the oxygen delivery display lamp that inserts described oxygen control unit, nitrogen conveying display lamp and the on and off switch that inserts described nitrogen control unit.
The animal experiment device capable that intermittence low-oxygen environment is provided of the present utility model, supply with by the circulation of oxygen loop control intervalometer and nitrogen circulation control timer control oxygen and nitrogen respectively, realize altofrequency hypoxia and the living environment of reoxygenation laboratory repeatedly, the aerofluxus control electromagnetic valve that inserts makes the air pressure in the feeding cabin be in atmospheric pressure state under the control of oxygen loop control intervalometer and nitrogen circulation control timer always, the animal experiment device capable that intermittence low-oxygen environment is provided of the present utility model simple in structure is convenient to experimental implementation.
Description of drawings
Fig. 1 is the structural representation of the gas control equipment of the animal experiment device capable that intermittence low-oxygen environment is provided of the present utility model;
Fig. 2 is the structural representation of the feeding cabin of the animal experiment device capable that intermittence low-oxygen environment is provided of the present utility model;
Fig. 3 is the circuit diagram of the gas control equipment of the animal experiment device capable that intermittence low-oxygen environment is provided of the present utility model.
Among the figure: 1-oxygen control electromagnetic valve, 2-aerofluxus control electromagnetic valve, 3-nitrogen control electromagnetic valve, 4-oxygen loop control intervalometer, 5-oxygen delivery display lamp, 6-on and off switch, 7-nitrogen circulation control timer, 8-nitrogen is carried display lamp, 9-oxygen intake, the 10-nitrogen inlet, the 11-air vent, box at the bottom of the 12-, 13-action pane, 14-porous interlayer board, the 15-dc source.
The specific embodiment
Below by the specific embodiment this utility model is described further.
The animal experiment device capable of intermittence low-oxygen environment that provides of the present utility model comprises gas control equipment and feeding cabin.As shown in Figure 1, described gas control equipment comprises oxygen control electromagnetic valve 1, aerofluxus control electromagnetic valve 2, nitrogen control electromagnetic valve 3, oxygen loop control intervalometer 4, nitrogen circulation control timer 7, and oxygen control electromagnetic valve 1, aerofluxus control electromagnetic valve 2, nitrogen control electromagnetic valve 3 have air inlet and gas outlet respectively.Described gas control equipment also comprises the oxygen delivery display lamp 5 that inserts described oxygen control unit, nitrogen conveying display lamp 8 and the on and off switch 6 that inserts described nitrogen control unit.
As shown in Figure 3, oxygen control electromagnetic valve 1 and the oxygen loop control intervalometer 4 oxygen control unit that is electrically connected to form, nitrogen control electromagnetic valve 3 and the nitrogen circulation control timer 7 nitrogen control unit that is electrically connected to form, described oxygen control unit and the described nitrogen control unit dc source 15 that inserts in parallel; Insert described oxygen control unit and described nitrogen control unit after aerofluxus control electromagnetic valve 2 connects a commutation diode respectively, be subjected to oxygen loop control intervalometer 4 and 7 controls of nitrogen circulation control timer.
The described feeding cabin rectangular box body that the poly (methyl methacrylate) plate of about 1 cm thick constitutes of serving as reasons, as shown in Figure 2, described feeding cabin has oxygen intake 9, nitrogen inlet 10 and air vent 11, is provided with end box 12, action pane 13 and porous interlayer board 14 in the described feeding cabin.
The air inlet and the gas outlet of oxygen control electromagnetic valve 1, aerofluxus control electromagnetic valve 2, nitrogen control electromagnetic valve 3, and the oxygen intake 9 of described feeding cabin, nitrogen inlet 10 and air vent 11 all have identical aperture.Oxygen intake 9 is communicated with the gas outlet of oxygen control electromagnetic valve 1, and nitrogen inlet 10 is communicated with the gas outlet of nitrogen control electromagnetic valve 3, and air vent 11 is communicated with the air inlet of gas exhausting valve.Described feeding cabin is provided with the oxygen concentration alarm probe, and oxygen intake 9 and nitrogen inlet 10 are provided with acoustic filter, and installation also is equipped with small fan in the cabin, and foregoing is readily appreciated that, does not therefore represent with accompanying drawing.
Below by concrete mode of operation this utility model is described further.
At first regulate the working time of cycle timer, oxygen loop control intervalometer 4 and nitrogen circulation control timer 7 all are the two setting-up time timers of ZN86 intelligence, regulate the intermittent time 50s of oxygen loop control intervalometer 4, and the working time is 10s; The working time of regulating nitrogen circulation control timer 7 is 20s, and the intermittent time is 40s; Aerofluxus control electromagnetic valve 2 is opened when oxygen control electromagnetic valve 1 is opened, and aerofluxus control electromagnetic valve 2 was also opened when nitrogen control electromagnetic valve 3 was opened.The back powered-down is set more than the affirmation.
Experimental mouse is put into feeding cabin, open oxygen and nitrogen current scale (SH-2 type) respectively, regulate flow, turn on the power switch 6, this moment, nitrogen control electromagnetic valve 3 and aerofluxus control electromagnetic valve 2 were opened, and input nitrogen makes oxygen concentration decline in the cabin in the cabin; Nitrogen control electromagnetic valve 3 and aerofluxus control electromagnetic valve 2 are closed automatically behind the 40s, keep low-oxygen environment 10s in the cabin; Then oxygen control electromagnetic valve 1 and aerofluxus control electromagnetic valve 2 are opened automatically, and input oxygen makes that oxygen concentration returns to normal level in the cabin in the cabin, closes automatically behind the 10s.So automatically switch, reach in the cabin hypoxia and reoxygenation environment repeatedly.The deafener of oxygen intake 9 and nitrogen inlet setting can reduce the gas quick high-pressure and enter sound in the cabin.Small fan is installed in the cabin, can be made the quick mixing of the gas that enters in the cabin, experimental mouse is in the oxygen concentration environment of homogeneous in the assurance cabin.
The feeding cabin sidewall has an aperture, and oxygen concentration alarm probe (DYB-7200 type hypoxia alarm) is installed, and the oxygen concentration alarm threshold value is set, when oxygen concentration in the cabin is crossed when low or too high, the warning of can blowing a whistle, the scientific research personnel is reaction treatment in time, prevents that experimental mouse from meeting accident.
The purpose of porous interlayer board 14 is to keep the laboratory animal environment with the excretory urine of experimental mouse and feces every omitting in printing in chassis 12 in the cabin; Also can deposit desiccant and sodica calx in the chassis 12, absorb the water vapour and the CO2 that discharge, chassis 12 can be extracted out, is convenient to clean and change medicine.For guaranteeing the seal of feeding cabin, airtight good hatch door has been installed in action pane 13 outsides.
Should be understood that, more than describe only to be in and illustrate purpose, can also carry out many changes and improvements, for example: described oxygen control unit and described nitrogen control unit also can be many groups, thereby connect a plurality of feeding cabins, the concrete structure of gas control equipment and feeding cabin also can be done suitable improvement.These changes and improvements are all within protection domain of the present utility model.
Claims (6)
1, a kind of animal experiment device capable that intermittence low-oxygen environment is provided, comprise gas control equipment and feeding cabin, it is characterized in that: described gas control equipment comprises oxygen control electromagnetic valve (1), aerofluxus control electromagnetic valve (2), nitrogen control electromagnetic valve (3), oxygen loop control intervalometer (4), nitrogen circulation control timer (7) and dc source (15), oxygen control electromagnetic valve (1), aerofluxus control electromagnetic valve (2), nitrogen control electromagnetic valve (3) has air inlet and gas outlet respectively, oxygen control electromagnetic valve (1) and oxygen loop control intervalometer (4) the oxygen control unit that is electrically connected to form, nitrogen control electromagnetic valve (3) and nitrogen circulation control timer (7) the nitrogen control unit that is electrically connected to form, described oxygen control unit and the described nitrogen control unit dc source (15) that inserts in parallel; Aerofluxus control electromagnetic valve (2) inserts described oxygen control unit and described nitrogen control unit after connecting a commutation diode respectively; Described feeding cabin has oxygen intake (9), nitrogen inlet (10) and air vent (11); Oxygen intake (9) is communicated with the gas outlet of oxygen control electromagnetic valve (1), and nitrogen inlet (10) is communicated with the gas outlet of nitrogen control electromagnetic valve (3), and air vent (11) is communicated with the air inlet of gas exhausting valve.
2, the animal experiment device capable that intermittence low-oxygen environment is provided according to claim 1 is characterized in that: oxygen control electromagnetic valve (1), aerofluxus control electromagnetic valve (2) all have identical aperture with the air inlet of nitrogen control electromagnetic valve (3) and oxygen intake (9), nitrogen inlet (10) and the air vent (11) of gas outlet and described feeding cabin.
3, the animal experiment device capable that intermittence low-oxygen environment is provided according to claim 1, it is characterized in that: described feeding cabin is provided with the oxygen concentration alarm probe, and oxygen intake (9) and nitrogen inlet (10) are provided with acoustic filter.
4, the animal experiment device capable that intermittence low-oxygen environment is provided according to claim 1, it is characterized in that: the rectangular box body of described feeding cabin for being made of poly (methyl methacrylate) plate is provided with end box (12), action pane (13) and porous interlayer board (14) in the described feeding cabin.
5, the animal experiment device capable that intermittence low-oxygen environment is provided according to claim 1 is characterized in that: the thickness of described lucite is 0.5-2 centimetre.
6, the animal experiment device capable that intermittence low-oxygen environment is provided according to claim 1 is characterized in that: described gas control equipment also comprises the oxygen delivery display lamp (5) that inserts described oxygen control unit, nitrogen conveying display lamp (8) and the on and off switch (6) that inserts described nitrogen control unit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2009201063708U CN201366050Y (en) | 2009-03-10 | 2009-03-10 | Animal experiment device for providing intermittent hypoxia environment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2009201063708U CN201366050Y (en) | 2009-03-10 | 2009-03-10 | Animal experiment device for providing intermittent hypoxia environment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201366050Y true CN201366050Y (en) | 2009-12-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2009201063708U Expired - Fee Related CN201366050Y (en) | 2009-03-10 | 2009-03-10 | Animal experiment device for providing intermittent hypoxia environment |
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| Country | Link |
|---|---|
| CN (1) | CN201366050Y (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102007871A (en) * | 2010-02-26 | 2011-04-13 | 范维林 | Atmospheric anaerobic environment simulation experiment device |
| CN102008353A (en) * | 2010-06-13 | 2011-04-13 | 黄俊明 | Device for low-oxygen partial-pressure animal breathing effect experiments |
| CN107691246A (en) * | 2017-10-31 | 2018-02-16 | 河北医科大学第医院 | Chronic intermittent hypoxia experimental animal system and its control method |
| CN114080360A (en) * | 2019-07-10 | 2022-02-22 | 大金工业株式会社 | Interior air conditioning device |
-
2009
- 2009-03-10 CN CNU2009201063708U patent/CN201366050Y/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102007871A (en) * | 2010-02-26 | 2011-04-13 | 范维林 | Atmospheric anaerobic environment simulation experiment device |
| CN102008353A (en) * | 2010-06-13 | 2011-04-13 | 黄俊明 | Device for low-oxygen partial-pressure animal breathing effect experiments |
| CN107691246A (en) * | 2017-10-31 | 2018-02-16 | 河北医科大学第医院 | Chronic intermittent hypoxia experimental animal system and its control method |
| CN114080360A (en) * | 2019-07-10 | 2022-02-22 | 大金工业株式会社 | Interior air conditioning device |
| CN114080360B (en) * | 2019-07-10 | 2023-06-27 | 大金工业株式会社 | Internal air conditioning device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Luo Qin Inventor after: Liu Zhihong Inventor after: Zhao Zhihui Inventor after: Zhang Hongliang Inventor after: Wang Yong Inventor after: Zhao Qing Inventor after: An Ruiming Inventor before: Luo Qin Inventor before: Liu Zhihong Inventor before: Zhang Hongliang Inventor before: Wang Yong Inventor before: An Ruiming |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: LUO QIN LIU ZHIHONG ZHANG HONGLIANG WANG YONG AN RUIMING TO: LUO QIN LIU ZHIHONG ZHAO ZHIHUI ZHANG HONGLIANG WANG YONG ZHAO QING AN RUIMING |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20091223 Termination date: 20130310 |