CN205964214U - Mould device is made to obstructive sleep apnea hypopnea syndrome mouse model - Google Patents
Mould device is made to obstructive sleep apnea hypopnea syndrome mouse model Download PDFInfo
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- CN205964214U CN205964214U CN201620372091.6U CN201620372091U CN205964214U CN 205964214 U CN205964214 U CN 205964214U CN 201620372091 U CN201620372091 U CN 201620372091U CN 205964214 U CN205964214 U CN 205964214U
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Abstract
The utility model discloses a mould device is made to obstructive sleep apnea hypopnea syndrome mouse model, including mouse body container, a head section of thick bamboo, closing mechanism, gasbag, mouse body container is used for holding the mouse health, a head section of thick bamboo is used for holding the mouse head, mouse body container with head section of thick bamboo intercommunication, the gasbag is located mouse body container with the position department that a head section of thick bamboo is linked together, the gasbag has the through -hole that supplies the mouse head to pass, works as when the gasbag is aerifyd, the gasbag can and cut off mouse neck location mouse body container with circulation of air between the head section of thick bamboo, the one end of a head section of thick bamboo has the air vent, closing mechanism with the air vent cooperation is used for control the switching of air vent. The utility model discloses a pathology physiology course of obstructive sleep apnea hypopnea syndrome can be planned than the face mould that makes perfect to the device to basic research for the obstructive sleep apnea hypopnea syndrome provides good animal models.
Description
Technical field
This utility model is related to a kind of obstruction sleep apnea-hypopnea syndrome (obstructive sleep
Apnea hypopnea syndrome, OSAHS) laboratory animal mouse model modeling device, be particularly suited for using rat or little
The basic research of Mus Studies On Blocking Sleep Apnea-hypopnea Syndrome.
Background technology
Obstruction sleep apnea-hypopnea syndrome (OSAHS) sickness rate is high, harm is big, with whole body multiple system disease
Disease is as all closely related in hypertension, coronary heart disease, diabetes, apoplexy etc..Research is had to think, anti-during the patient sleeps of OSAHS
Multiple anoxia, microarousal and sleep deprivation are to cause the key factor of body damage, but its specific pathogenesis still ten is not distinguished
Chu.For this reason, people's constantly various animal model of research and probe, to the pathophysiological process of analog sleeping apnea patient
As above Airway Collapse, interval anoxia etc., thus furtheing investigate this sick pathogenesis, finds effective medicine and other treatment handss
Section.In past more than 20 year, for the Pathophysiology of a certain of OSAHS or certain several respect, people have been developed over various types of
The OSAHS mouse model of type.
1st, natural obstructive sleep apnea animal model
Fat New Zealand mice (NZO) is done with MRI measure, its internal organs and neck fat increase, tongue, soft palate and lateral wall of pharynx
Plump.Observe that during mice sleep, inspiratory airflow lowers.Although but mice has airway constriction, do not occur genioglossus fortune
Dynamic enhancing, and sleep period (or even in REM phase) its epithelium healing also keeps stable.Whether this model can cause functional air-flow
Block or limited not clear, and non-obese OSAHS can not be simulated.
2nd, through the obstructive sleep apnea animal model of experiment induction
No matter which kind of laboratory animal, all cannot show the idiopathic obstruction asphyxia consistent with the mankind completely.Domestic
Outer scholar invented many OSAHS experimental animal models come to study mankind's obstruction sleep apnea-hypopnea syndrome and its
Impact to cardiovascular, metabolism, psychology and other health problems.
2.1 utilize anoxia storehouse to manufacture animal model
The anoxia storehouse being set by distinct program, intermittent hypoxia and reoxygenation repeatedly under simulation OSAHS patient sleeps' state
This feature, to inquire into pathogenesis, pathophysiological process and medicament research and development of OSAHS etc..This modeling method is the most commonly used
And relatively stable, reliable, simultaneously little to injury of laboratory animal, simple and easy to do.
2.1.1 interval hypoxia model
In the last few years, with the development of technology, interval hypoxia storehouse constantly improve and improvement, highly developed and easy,
As long as rat or mice are put in warehouse, by the concentration of Computer Design hypoxia, the time of hypoxia and cycle-index etc.
, it has also become the main method of OSAHS animal model.Experimental mouse is placed in cabin, is replaced thereto with the frequency setting
The gas simulation interval hypoxia of injection low oxygen concentration and normal oxygen concentration, the persistent period is depending on research needs.Application is intermittent
Anoxia storehouse setting up OSAHS model, due to giving intervening measure by casing, then for the animal putting into casing,
There is no particular/special requirement to its apneic degree and type.
It should be noted that due to the objective feature of chronic intermittent hypoxia equipment, dense in setting anoxia frequency, hypoxia
On degree and duration, each research is different.These differences are possible to occur the difference of pathophysiological process.It is true that people
Class OSAHS is a multi-factor disease, also variant in the degree of hypoxemia and the frequency of hypoxia.So although chronic
Disconnected property anoxia model can represent OSAHS segment pathology physiological process, but must set up a standardization, repeatable chronic
Disconnected property anoxia model.
2.1.2 interval hypoxia is with high CO2Model
, in Upper airway obstruction, not only hypoxia, simultaneously also with hypercapnia for OSAHS patient.Therefore, set up interval
The animal model of anoxia companion's hypercapnia more meets the pathophysiological conditions of OSAHS.Interval hypoxia is with high CO2Warehouse is set up
It is similar with single batch anoxia storehouse, simply many CO2Interface, high pressure CO can be connected2Gas cylinder, and pass through computer
Setting CO2Concentration and air inflow.
2.1.3 according to sleep state oxygen-supplying model
Above-mentioned anoxia storehouse does not consider the sleep state of laboratory animal.In view of the hypoxia of OSAHS patient occurs all in sleep,
Therefore the sleep state having scholar to develop by computer monitoring, judge animal, only supply hypoxia in sleep period, in microarousal with clearly
The anoxia storehouse of normal concentration oxygen is supplied under awake state.
Although there is a fixed limit closer to clinical OSAHS patient's states, this device to single modeling quantity in this model
System.And the modeling persistent period is by can the sleep analysis monitor signal of stable existence determine.So, for the long-term exposure of needs
For chronic intermittent hypoxia environment to study the research of OSAHS pathological change, lichen simplex intermittent hypoxia model is still
Existing modeling method the most simple and practical.
The narrow animal model of 2.2 artificial epithelium healing
Another important feature of OSAHS be epithelium healing subside obstruction and thoracic cavity in negative pressure increase.Therefore, to pharyngeal
The intervention of (including oropharynx and glossopharyngeum) becomes another main method setting up OSAHS model and selection.
2.2.1 simulation epithelium healing subsides-reopens the modeling method put
Almendros et al. is built into 2 intubations in experimental rat trachea, and 1 pipe is placed in trachea hypomere, enables animal
General breathing, another Guan Ze is placed in epithelium healing, through a three-way valve respectively with-a 40cmH2The negative pressure air-suction device of O
With a 4cmH2The positive airway pressure device of O is connected, and installs one simultaneously and communicate with air through electric valve on the nose of rat
Conformal face mask, by closing nasal mask valve and opening negative pressure valve and so that epithelium healing negative pressure is subsided, by opening nasal surface simultaneously
Cover valve and malleation valve make epithelium healing reopening put, so that epithelium healing is in the mode playback that periodically subsides-reopen.To upper gas
Road pressure and nasal mask pressure carry out real-time monitoring, and record air flue flow.When airway pressure is higher than the pressure making Airway Collapse
(critical pressure, this is tested as -15cmH2O), nasal pressure is consistent with tracheal pressure, shows airway open；Face when airway pressure is less than
During boundary's pressure, nasal pressure does not decline with airway pressure, because air flue now subsides.But this model can not simulate long-term OSAHS
Pathophysiological change.
2.2.2 three-way valve is connect by tracheal intubation and make model
Yu-ki Iwasaki et al. to SD rat daily circulation of qi promoting cannula and connects tee T in tracheal intubation, is passed through 2%
Isoflurane anesthesia (respirator：72 beats/min of tidal volume 2.5ml, respiratory frequency).Air flue is closed 40 seconds by end-tidal, subsequently
Open airway 80 seconds, daily 20 times simulating OSAHS.After OSAHS circulation, blowing air, so that rat is recovered from anesthesia.Recover
Tube drawing after autonomous respiration.The method embodies negative pressure in the chronic intermittent hypoxia of OSAHS and thoracic cavity simultaneously, and can persistently simulate
For a period of time, but the multiple intubation of animal easily causes Accessory injury, need the higher technology of operator and stability.
The pathogenesis of sleep disordered breathing are complicated, and still not setting up one at present can be with comprehensive simulated sleep disordered breathing disease
The animal model of reason physiological process.From the foregoing, it can be seen that natural obstructive sleep apnea animal model is unable to mould
Intend non-obese OSAHS；Interval hypoxia model only represents OSAHS segment pathology physiological process, and equipment cost is high, it is all to order goods
Phase length, maintenance difficult, need using the relatively hazardous gas such as oxygen；The artificial narrow animal model of epithelium healing need to be repeatedly numb by animal
Liquor-saturated, morbid state can not be simulated for a long time, operation can easily cause Accessory injury, needs the higher technology of operator and stability.Cause
This, these models have certain limitation.
OSAHS animal model there is no generally acknowledged evaluation criterion at present, mainly sees animal model and mankind's OSAHS disease of making
Whether sick feature is consistent.Evaluate emphasis mainly to include：1. whether there are the sleep apnea that Upper airway obstruction causes and low pass gas；
2. whether in asphyxia or low pass gas with negative pressure in hypoxemia and thoracic cavity；3. can observing and nursing sleep quality and point
The change that in analysis sleep, obstructing event occurs and brain is electric；4. whether reproducible OSAHS clinical symptoms.
Utility model content
(1) technical problem to be solved
In view of all there is many lacking in operation or action effect in the device of modeling method of the prior art or its use
Fall into, the purpose of this utility model is to provide a kind of brand-new obstruction sleep apnea-hypopnea syndrome mouse model modeling dress
Put, using this device, modeling is carried out to rat or mice, being capable of comprehensive simulated obstruction sleep apnea-hypopnea syndrome
Pathophysiological process, thus providing good animal mould for the basic research of obstruction sleep apnea-hypopnea syndrome
Type.
(2) technical scheme
For solving above-mentioned technical problem, this utility model provides following technical proposals：
A kind of obstruction sleep apnea-hypopnea syndrome mouse model modeling device, including Mus body container, head cylinder, opens
Close mechanism, air bag；
Described Mus body container is used for accommodating Mus body；
Described head cylinder is used for accommodating Mus head, and described Mus body container is connected with described head cylinder；
At the position that described Mus body container is connected with described head cylinder, described air bag has for Mus head described air bag
The through hole passing through, when described airbag aeration, Mus cervical region can be positioned and separate described Mus body container and described head by described air bag
Air circulation between cylinder；
One end of described head cylinder has passage, and described switching mechanism is coordinated with described passage, described logical for controlling
The opening and closing of pore.
Wherein, described air bag preferably can be fixed on described Mus body container inside and be located at described Mus body container close
One end of described head cylinder.Described air bag is preferably an annular air-pocket, has one and be available for the through hole that Mus head passes through in the middle of it.Described
Air bag realizes the inflatable and deflatable of air bag preferably by an outside air delivery device and a breather, and wherein, described breather is worn
The ventilation pore crossed positioned at described Mus body container one end near described head cylinder will described air bag and described outside air delivery device reality
Now connect.
Described Mus body container is preferably cylindrical shape；Described Mus body container preferably has logical near one end of described head cylinder
Tracheal orifice.
Described head cylinder is preferably wedge shape tubular, with the head of Mus of preferably fitting.
CO preferably also can be installed in described head cylinder2Or O2Concentration detection device, to coordinate experiment needs, in detecting head cylinder
CO2Or O2Concentration.
Described head cylinder can be to be flexibly connected or be integrally formed to be connected with described Mus body container.When described head cylinder
When being connected with described Mus body container activities, preferably can realize described flexible connection by a connection ring.
Described switching mechanism is preferably a cylinder Air-tight piston head, and described head cylinder Air-tight piston head is joined with described passage
Close, when described head cylinder Air-tight piston head is fitted with described passage, described head cylinder is in air-tight state, when the airtight work of described head cylinder
When chock plug is separated with described passage, described head cylinder is in aeration status；
Described head cylinder Air-tight piston head preferably by one controller control move, with realize described head cylinder Air-tight piston head with
The laminating of described passage with separate.
It is described that described obstruction sleep apnea-hypopnea syndrome mouse model modeling device preferably also includes control
The thermostat of Mus body container local environment temperature, the preferred tank of described thermostat, when device works, can be in tank
Pour into the water of uniform temperature, to keep the temperature constant state of Mus body container local environment.
Described obstruction sleep apnea-hypopnea syndrome mouse model modeling device preferably also includes a base, institute
State base for installing the Each part of described modeling device.
On the basis of meeting common sense in the field, above-mentioned each optimum condition can combination in any, obtain final product this utility model each relatively
Good example.
(3) beneficial effect
This utility model achieves following beneficial effects：
1st, in this utility model, the OSAHS state of simulation can cover chronic intermittent hypoxia and intrathoracic pressure increases, and this is
Conventional modeling device cannot be accomplished；
2nd, this utility model can monitor OSAHS modeling Mus blood oxygen situation of change, the effectiveness of reflection modeling at any time；
3rd, this utility model is no performed the operation to modeling experimental mouse Accessory injury, and it will not be caused with the pressure under the conditions of physiological limit
Compel, need not anaesthetize or only calmness analog sleeping modeling, the persistent period is long, be more beneficial for the research to this kind of chronic disease of OSAHS；
4th, this utility model is easy and simple to handle, and equipment volume is little, the relevant risk such as no inflammable and explosive, low cost.
Brief description
Fig. 1 is the planar structure schematic diagram of modeling device in this utility model embodiment 1.
Fig. 2 is the perspective view of modeling device in this utility model embodiment 1.
Fig. 3 is that often circulation causes the asphyxia OSAHS mould of 60 seconds for 90 seconds for application modeling device of the present utility model setting
Blood oxygen change (A) of type and mankind OSAHS patient sleeps monitor the comparison diagram of blood oxygen change (B).
Specific embodiment
For making the purpose of this utility model, technical scheme and advantage become more apparent, below in conjunction with specific embodiment, and
Referring to the drawings, the utility model is described in further detail.
This utility model provides a kind of obstruction sleep apnea-hypopnea syndrome mouse model modeling device, including Mus
Body container, head cylinder, switching mechanism, air bag；
Described Mus body container is used for accommodating Mus body；
Described head cylinder is used for accommodating Mus head, and described Mus body container is connected with described head cylinder；
At the position that described Mus body container is connected with described head cylinder, described air bag has for Mus head described air bag
The through hole passing through, when described airbag aeration, Mus cervical region can be positioned and separate described Mus body container and described head by described air bag
Air circulation between cylinder；
One end of described head cylinder has passage, and described switching mechanism is coordinated with described passage, described logical for controlling
The opening and closing of pore.
This utility model one preferred embodiment in, described air bag is the air bag of an endless belt through hole, and it is fixed on
The inside of described Mus body container and be located at described Mus body container near one end of described head cylinder, this air bag is available for Mus head and passes through,
And in airbag aeration, Mus cervical region is positioned and separates the air circulation between described Mus body container and described head cylinder.Described gas
Capsule realizes the inflatable and deflatable of air bag by an outside air delivery device and a breather, and wherein, described breather is placed through institute
Described air bag and described outside air delivery device are realized connecting by the ventilation pore stating Mus body container one end near described head cylinder.
Described Mus body container is placed in a tank, and this tank can pour into the constant temperature that warm water keeps Mus body container.Device
Each part is installed on a base, to be convenient for carrying and to manipulate.
In another preferred implementation of the present utility model, described switching mechanism is a cylinder Air-tight piston head, described
Head cylinder Air-tight piston head and described passage cooperation, when described head cylinder Air-tight piston head is fitted with described passage, described head
Cylinder is in air-tight state, and when described head cylinder Air-tight piston head is separated with described passage, described head cylinder is in aeration status.Described head
Cylinder Air-tight piston head is controlled by a controller and moves, to realize fitting and dividing of described head cylinder Air-tight piston head and described passage
Open.Described controller includes a control panel, and it connects power supply by power line, described control panel can set head cylinder close
Close piston head with head cylinder closure and open time cyclic program, the unit of time that can set includes：Second, 0.1 minute, minute and
Hour, experimenter can be optionally specifically chosen according to actual needs.
In further embodiment of the present utility model, it is real that described Mus body container and described head cylinder pass through a connection ring
Now connect, described Mus body container has bayonet socket near one end of described head cylinder, by blocking screw further through described bayonet socket
Tightly described connection ring, realizes the firm connection of described Mus body container and described head cylinder.
Specific embodiment is presented herein below, for further describing construction featuress, the work of this utility model device in detail
Make principle and technique effect.
Embodiment 1
As depicted in figs. 1 and 2, the obstruction sleep apnea-hypopnea syndrome mouse model modeling dress of the present embodiment
Put, including Mus body container 3, head cylinder 9, connection ring 7, switching mechanism, air bag 4, controller 15；
Described Mus body container 3 is used for accommodating Mus body；
Described head cylinder 9 is used for accommodating Mus head, and described Mus body container 3 is connected with described head cylinder 9 by connection ring 7；Described
Mus body container 3 has bayonet socket 6 near one end of described head cylinder 9, is connected described in the further clamping of described bayonet socket 6 by passing through screw
Connect ring 7, realize the firm connection of described Mus body container 3 and described head cylinder 9.
At the position that described Mus body container 3 is connected with described head cylinder 9, described air bag 4 has and supplies Mus described air bag 4
The through hole that head passes through, when described air bag 4 is inflated, described air bag 4 Mus cervical region can be positioned and separate described Mus body container 3 with
Air circulation between described head cylinder 9；Described air bag 4 passes through an inflating ball 8 and a breather 5 is realized the inflation of air bag 4 and put
Gas, wherein, described breather 5 is placed through the ventilation pore of described Mus body container 3 one end near described head cylinder 9 by described gas
Capsule 4 and described inflating ball 8 are realized connecting.
One end of described head cylinder 9 has passage, and described switching mechanism is coordinated with described passage, described logical for controlling
The opening and closing of pore.
Described switching mechanism is a cylinder Air-tight piston head 10, and described head cylinder Air-tight piston head 10 is joined with described passage
Close, when described head cylinder Air-tight piston head 10 is fitted with described passage, described head cylinder 9 is in air-tight state, when described head cylinder is close
When closing piston head 10 and separating with described passage, described head cylinder 9 is in aeration status.Described head cylinder Air-tight piston head 10 is controlled by one
Device 15 controls and moves, to realize fitting and separating of described head cylinder Air-tight piston head 10 and described passage.
In practical operation, set described head cylinder Air-tight piston head 10 first in the control panel 21 of controller 15 airtight
Head cylinder 9 and the time cyclic program of open head cylinder 9, unit of time includes：Second, 0.1 minute, minute and hour.By Mus body container
3rd, connection ring 7, air bag 4, head cylinder 9 connect, on the Mus body container draw-in groove being placed in then be put in a tank 2 base 1, by Mus
As for Mus body container 3 rear portion, Mus will voluntarily pierce in Mus body container 3, and Mus head enters head cylinder 9, extrude inflating ball 8, by ventilation
Pipe 5 to air bag 4 gas injection, Mus head is fixed in head cylinder 9 and with Mus body container 3 air exclusion, adjustment head cylinder 9 position and Mus in front and back
Head laminating.Preference temperature water is injected in tank 2.Controller 15 and head cylinder Air-tight piston head 10, power supply are connected by data wire 14
Line 16 connects power supply, the plug 17 that power line 16 band switches on power.Open switch 19 to pass through according to the cyclic program setting
Data line interface 13 receives program singal, completes piston impeller-hub 12 and drives piston rod 11 to move back and forth, makes head cylinder Air-tight piston
10 are completed to close and Opening Ventilation hole by cyclic program with the blow vent on head cylinder 9, and cogwheel breathing is temporary repeatedly to complete simulation Mus
The model stopping.The display screen 20 of controller 15 can show the real-time time in each circulation, can be suspended at any time by Pause key 18
Cyclic program.
As shown in figure 3, it is that often circulation causes asphyxia 60 seconds in 90 seconds for application modeling device of the present utility model setting
Blood oxygen change (A) and mankind OSAHS patient sleeps of OSAHS model monitor the comparison diagram of blood oxygen change (B).Permissible from figure
Find out, this modeling device can replicate the blood oxygen change that the asphyxia repeatedly under OSAHS state causes completely.Meanwhile, by exhaling
Inhale the chest and abdomen dyskinesis of Mus when suspending it is achieved that intrathoracic pressure repeatedly under OSAHS state.After noinvasive modeling, Mus health shape
Condition is good, and whole process does not cause the compressing under the conditions of any physiological limit to it.
Particular embodiments described above, has carried out entering one to the purpose of this utility model, technical scheme and beneficial effect
Step describes in detail it should be understood that the foregoing is only specific embodiment of the utility model, is not limited to this reality
With new, all within spirit of the present utility model and principle, any modification, equivalent substitution and improvement done etc., all should comprise
Within protection domain of the present utility model.
Claims (13)
1. a kind of obstruction sleep apnea-hypopnea syndrome mouse model modeling device holds it is characterised in that including Mus body
Device, head cylinder, switching mechanism, air bag；
Described Mus body container is used for accommodating Mus body；
Described head cylinder is used for accommodating Mus head, and described Mus body container is connected with described head cylinder；
At the position that described Mus body container is connected with described head cylinder, described air bag has and passes through for Mus head described air bag
Through hole, when described airbag aeration, described air bag Mus cervical region can be positioned and separate described Mus body container and described head cylinder it
Between air circulation；
One end of described head cylinder has passage, and described switching mechanism is coordinated with described passage, for controlling described passage
Opening and closing.
2. obstruction sleep apnea-hypopnea syndrome mouse model modeling device according to claim 1, its feature
It is, described air bag is fixed on the inside of described Mus body container and is located at described Mus body container near one end of described head cylinder.
3. obstruction sleep apnea-hypopnea syndrome mouse model modeling device according to claim 1, its feature
It is, described air bag is an annular air-pocket, has a through hole passing through for Mus head in the middle of it.
4. obstruction sleep apnea-hypopnea syndrome mouse model modeling device according to claim 1, its feature
It is, described air bag is passed through a breather and connected with an outside air delivery device, to realize the inflatable and deflatable of air bag, wherein, institute
State the ventilation pore that breather is placed through described Mus body container one end near described head cylinder.
5. obstruction sleep apnea-hypopnea syndrome mouse model modeling device according to claim 1, its feature
It is, described Mus body container is cylindrical shape.
6. obstruction sleep apnea-hypopnea syndrome mouse model modeling device according to claim 1, its feature
It is, described head cylinder is wedge shape tubular.
7. obstruction sleep apnea-hypopnea syndrome mouse model modeling device according to claim 1, its feature
It is, CO is installed in described head cylinder2Or O2Concentration detection device.
8. obstruction sleep apnea-hypopnea syndrome mouse model modeling device according to claim 1, its feature
It is, described head cylinder is connected with described Mus body container activities or is integrally formed connection.
9. obstruction sleep apnea-hypopnea syndrome mouse model modeling device according to claim 8, its feature
It is, when described head cylinder is connected with described Mus body container activities, realize described flexible connection by a connection ring.
10. obstruction sleep apnea-hypopnea syndrome mouse model modeling device according to claim 1, its feature
It is, described switching mechanism is a cylinder Air-tight piston head, and described head cylinder Air-tight piston head is coordinated with described passage, when described
When head cylinder Air-tight piston head is fitted with described passage, described head cylinder is in air-tight state, when described head cylinder Air-tight piston head and institute
State passage separately when, described head cylinder is in aeration status；
Described head cylinder Air-tight piston head controls movement by a controller, to realize described head cylinder Air-tight piston head and described passage
Laminating with separate.
11. obstruction sleep apnea-hypopnea syndrome mouse model modeling devices according to claim 1, its feature
It is, also include controlling the thermostat of described Mus body container local environment temperature.
12. obstruction sleep apnea-hypopnea syndrome mouse model modeling devices according to claim 11, it is special
Levy and be, described thermostat is tank, and described tank is around described Mus body container.
13. obstruction sleep apnea-hypopnea syndrome mouse model modeling devices according to claim 1, its feature
It is, also includes a base, described base is used for installing the Each part of described modeling device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620372091.6U CN205964214U (en) | 2016-04-28 | 2016-04-28 | Mould device is made to obstructive sleep apnea hypopnea syndrome mouse model |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620372091.6U CN205964214U (en) | 2016-04-28 | 2016-04-28 | Mould device is made to obstructive sleep apnea hypopnea syndrome mouse model |
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| CN205964214U true CN205964214U (en) | 2017-02-22 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853016A (en) * | 2016-04-28 | 2016-08-17 | 首都医科大学附属北京安贞医院 | Modeling device for mouse with OSAHS (obstructive sleep apnea hypopnea syndrome) |
| CN109350298A (en) * | 2018-12-20 | 2019-02-19 | 天津市胸科医院 | Realize the ventilation adjusting device of intermittent airway obstruction |
| CN110882086A (en) * | 2018-09-11 | 2020-03-17 | 首都医科大学附属北京安贞医院 | Model making device for obstructive sleep apnea hypopnea syndrome animal model |
-
2016
- 2016-04-28 CN CN201620372091.6U patent/CN205964214U/en not_active Withdrawn - After Issue
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853016A (en) * | 2016-04-28 | 2016-08-17 | 首都医科大学附属北京安贞医院 | Modeling device for mouse with OSAHS (obstructive sleep apnea hypopnea syndrome) |
| CN105853016B (en) * | 2016-04-28 | 2017-06-27 | 首都医科大学附属北京安贞医院 | Obstruction sleep apnea-hypopnea syndrome mouse model modeling device |
| CN110882086A (en) * | 2018-09-11 | 2020-03-17 | 首都医科大学附属北京安贞医院 | Model making device for obstructive sleep apnea hypopnea syndrome animal model |
| CN110882086B (en) * | 2018-09-11 | 2022-07-15 | 首都医科大学附属北京安贞医院 | Obstructive sleep apnea hypopnea syndrome animal model making device |
| CN109350298A (en) * | 2018-12-20 | 2019-02-19 | 天津市胸科医院 | Realize the ventilation adjusting device of intermittent airway obstruction |
| CN109350298B (en) * | 2018-12-20 | 2020-12-22 | 天津市胸科医院 | Ventilation regulating and controlling equipment for realizing intermittent airway obstruction |
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