CN202153926U - Rat model for pediatric obstructive sleep apnea-hypopnea syndrome (OSAHS) intermittent hypoxia - Google Patents
Rat model for pediatric obstructive sleep apnea-hypopnea syndrome (OSAHS) intermittent hypoxia Download PDFInfo
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- CN202153926U CN202153926U CN2011202593380U CN201120259338U CN202153926U CN 202153926 U CN202153926 U CN 202153926U CN 2011202593380 U CN2011202593380 U CN 2011202593380U CN 201120259338 U CN201120259338 U CN 201120259338U CN 202153926 U CN202153926 U CN 202153926U
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Abstract
The utility model discloses a rat model for pediatric obstructive sleep apnea-hypopnea syndrome (OSAHS) intermittent hypoxia, which belongs to an experimental device in the field of medical experiments and solves the defect of the lack of the rat model for the pediatric OSAHS intermittent hypoxia in the prior art. The rat model mainly comprises a box body, wherein the box body is internally provided with a partition A, a partition B, a door A and a door B, an inner chamber of the box body is divided into a hypoxia cabin, a transitional cabin and an animal cabin, the animal cabin is communicated with atmosphere, the door A and the door B can be opened through vertical movement, the box body is internally provided with an animal feed box which can move left and right in the boxy body, and the hypoxia cabin is provided with a nitrogen gas valve and an oxygen concentration sensing device. The rat model is mainly used in animal experiments in the field of medical science.
Description
Technical field
The utility model belongs to a kind of experimental provision in medical experiment field, specifically, relates in particular to intermittently Hypoxic Rats model of a kind of children's obstructive sleep apnea low syndrome.
Background technology
(this disease incidence of disease is higher for obstructive sleep apnea hypopnea syndrome, comparatively common disease childhood of OSAHS) being, potential serious harm children's health and growing for children's obstructive sleep apnea low syndrome.The characteristics of children OSAHS are frequent part or all of upward airway obstructions that take place in the sleep procedure, cause that low ventilation or ventilation temporarily stop, thereby upset children's normal ventilation and Sleep architecture cause a series of pathophysiological change.The change that sleep apnea possibly cause the sluggishness of growing, feeblemindedness, psychological abnormal behavior, conduction deafness and the face developmental deformity of infant with low ventilation even cardiac function occur appears for a long time.Yet the domestic and international at present research for children OSAHS still stays in clinical experimental stage; Because the restriction of case source, number and clinical diagnosis level; Can't accomplish in the research comprehensively with objective; Can't study the influence of this disease for each system of whole body exactly more, but not see the report of children OSAHS animal model both at home and abroad up to now, therefore setting up children OSAHS anoxic animal model at intermittence as early as possible has profound significance.Owing to the caused numerous harm of children OSAHS mostly are because due to the long-term discontinuity hypoxemia, so cause the blood oxygen saturation of discontinuity to reduce the key that becomes children OSAHS animal model.And how simulate hypoxemia at intermittence in various degree through oxygen concentration in accurately controling environment and open-assembly time, make that to reach the clinical diagnosis standard be to set up the difficult point of model.
Summary of the invention
The purpose of the utility model provides intermittently Hypoxic Rats model of a kind of children's obstructive sleep apnea low syndrome, to solve the defective that lacks children OSAHS animal model in the prior art.
The utility model is to adopt following technical scheme to realize: a kind of children's obstructive sleep apnea low syndrome is the Hypoxic Rats model intermittently; Comprise casing; Be provided with in the casing and cut off A, partition B, door A and door B and cabinets cavity is divided into hypoxemia cabin, transfer chamber and animal capsule; Animal capsule and atmosphere, door A can move up and down unlatching with door; Be provided with the animal feeding case in the casing, the animal feeding case can be in casing move left and right; The hypoxemia cabin is provided with nitrogen valve, oxygen concentration sensing appearance.
Said children's obstructive sleep apnea low syndrome intermittently Hypoxic Rats model can be provided with electromotor A and electromotor B; Casing is provided with two apertures; Door A) be respectively equipped with suspender belt A and suspender belt B with B, suspender belt A is connected with the power take-off of electromotor B with electromotor A through aperture respectively with suspender belt B;
Can be provided with one or more than one sidewall handle hole on the casing;
Preferably be provided with two sidewall handle holes on the casing;
The below of casing can be provided with leading screw, and the bottom of animal feeding case is provided with screw, and screw is spun on the leading screw, and the base plate of casing is provided with lip shape band;
Preferably be provided with bearing between leading screw and the casing;
Funnel structure is preferably adopted down at the top in hypoxemia cabin, and the bottom of casing preferably is provided with the case leg.
Compared with prior art; The beneficial effect of the utility model is: use the utility model children obstructive sleep apnea low syndrome intermittently the Hypoxic Rats model to childhood rat experimentize; Can truly reflect the following intermittently anaerobic condition of clinical middle children sleeping state; Change the concentration and the open-assembly time of hypoxemia through repetition test, finally make degree of oxygen deficiency, the time that anoxic event takes place and frequency meet all that children OSAHS is light, the severe standard.
Description of drawings
Fig. 1 is the front view of the utility model;
Fig. 2 is the upward view of the utility model;
Fig. 3 is the partial enlarged drawing A of Fig. 1.
Among the figure: 1, nitrogen valve; 2, oxygen concentration sensing appearance; 3, hypoxemia cabin; 4, electromotor B; 5, transfer chamber; 6, electromotor A; 7, animal capsule; 8, animal feeding case; 9, casing; 10, bearing; 11, leading screw; 12, case leg; 13, screw; 14, lip shape band; 15, door A; 16, suspender belt A; 17, cut off A; 18, sidewall handle hole; 19, door B; 20, suspender belt B; 21, cut off B; 22, aperture; 23, base plate.
Embodiment
Below in conjunction with accompanying drawing the utility model is described further.
Children's obstructive sleep apnea low syndrome intermittently Hypoxic Rats model comprises casing (9); The inner chamber of casing (9) is separated into three cavitys by door A15, door B19, partition A17 and partition B21; That is: hypoxemia cabin 3, transfer chamber 5 and 7, three cavitys of animal capsule are airtight relatively; Door A15, door are respectively equipped with suspender belt A16 and suspender belt B20 above the B19; Suspender belt A16 is connected with the power take-off of electromotor B4 with electromotor A6 respectively with suspender belt B20; Electromotor A6 and electromotor B4 can just change or reverse; Thereby can drive an A15, door B19 rises or fall, the place that door A15, door B19 both sides contact with casing also can be provided with gathering sill; The bottom of casing (9) is provided with leading screw 11, lip shape band 14; The bottom of animal feeding case 8 is fixed with screw 13, and screw 13 cooperatively interacts with leading screw 11, and leading screw 11 is fixed on the casing 9 through bearing 10; When leading screw 11 rotations; Animal feeding case 8 can hypoxemia cabin 3, move horizontally between transfer chamber 5 and the animal capsule 7, and lip shape band 14 plays sealing function, automatic airtight after screw 13 streaks.
When using the utility model, the bottleneck of high-purity nitrogen gas cylinder is connected with nitrogen valve 1 through pipeline, nitrogen valve 1 passes through lead and is connected with oxygen concentration sensing appearance 2, and the power intake of leading screw 11 is connected with the motor power axle, and connects automatic control system; Rubber gloves oppositely are installed on two sidewall handle holes 18, and rubber gloves both can play the effect of sealing sidewall handle hole 18, again can be so that hand is inserted gloves in casing (9), operate.
The application principle of the utility model is:
In order to make constructed animal model can truly reflect the following intermittently anaerobic condition of clinical middle children sleeping state; The utility model has been chosen childhood rat discontinuity and has been exposed to low-oxygen environment; Change the concentration and the open-assembly time of hypoxemia through repetition test, finally make degree of oxygen deficiency, the time that anoxic event takes place and frequency meet all that children OSAHS is light, the severe standard.Specific as follows:
Model is selected 25 ages in days-60 age in days rat for use, because should the stage rat growthing development the rapidest, gets into sexual maturing period behind 60 ages in days, but this simulating human children stage in stage.Rat model is raised in intermittence hypoxia test case.Adopt folder to refer to the blood oxygen saturation of the blood oxygen saturation appearance mensuration rat of type probe; When rat breaks away from low-oxygen environment, immediately with probe clip in rat root of the tail portion, measure immediately and record; Be minimum blood oxygen saturation this moment; When rat will get into low-oxygen environment once more, measure blood oxygen saturation and record immediately, be the intermittent phase blood oxygen saturation this moment.Oxygen concentration maintains 6%-8% in the low-oxygen environment., the temperature maintenance of low-oxygen environment is at 19-21 ℃, and humidity is 30%-50%, carbonic acid gas volume fraction＜0.03.Slight group stops 6s in anaerobic environment, and atmospheric exposure 600s is one-period, continues circulation 8 hours, minimum blood oxygen saturation average out to 85.25% every day.The severe group stops 6s in the anoxic cabin; Atmospheric exposure 150s is one-period, continues 8 hours minimum blood oxygen saturation average out to 77.625% every day; Blood oxygen saturation after laboratory animal returns atmospheric environment is light, the severe group is 98%-100%, can realize intermittently anoxic.The hypoxemia incident per hour takes place 6 times in slight group anoxic 6s, and promptly sleep apnea/(apnea-hypopnea index AHI) is 6 times/h to low ventilation index; The hypoxemia incident per hour takes place 24 times in severe group anoxic 6s, and promptly AHI is 24 times/h.Test all needed to carry out daytime in 8 hours, made animal be in sleep state.Use the constructed children OSAHS of this method model, animal origin is extensive, and feeding cost is lower, and is non-invasive operation, and the animal maintenance cost is also lower, is easy to realize.It is accurate that this animal model all meets children OSAHS weight scale in degree of oxygen deficiency, the time that anoxic event takes place and frequency; Can react the sleep period anaerobic condition at intermittence of children OSHS preferably, the influence to each system of whole body has great significance for this disease of research.
Claims (7)
1. children's obstructive sleep apnea low syndrome Hypoxic Rats model intermittently; Comprise casing (9); It is characterized in that: be provided with in the casing (9) and cut off A (17), partition B (21), door A (15) and door B (19) and cabinets cavity is divided into hypoxemia cabin (3), transfer chamber (5) and animal capsule (7); Animal capsule (7) and atmosphere, door A (15) and door (19) can move up and down unlatching; Be provided with animal feeding case (8) in the casing (9), animal feeding case (8) can be in casing move left and right; Hypoxemia cabin (3) is provided with nitrogen valve (1), oxygen concentration sensing appearance (2).
2. children's obstructive sleep apnea low syndrome according to claim 1 is the Hypoxic Rats model intermittently; It is characterized in that: be provided with electromotor A (6) and electromotor B (4); Casing (9) is provided with two apertures (22); Door A (15) and door B (19) are respectively equipped with suspender belt A (16) and suspender belt B (20), and suspender belt A (16) is connected with the power take-off of electromotor B (4) with electromotor A (6) through aperture (22) respectively with suspender belt B (20).
3. children's obstructive sleep apnea low syndrome according to claim 1 is the Hypoxic Rats model intermittently, it is characterized in that: casing (9) is provided with one or more than one sidewall handle hole (18).
4. children's obstructive sleep apnea low syndrome according to claim 3 is the Hypoxic Rats model intermittently, and it is characterized in that: casing (9) is provided with two sidewall handle holes (18).
5. children's obstructive sleep apnea low syndrome according to claim 1 is the Hypoxic Rats model intermittently; It is characterized in that: the below of casing (9) is provided with leading screw (11); The bottom of animal feeding case (8) is provided with screw (13); Screw (13) is spun on the leading screw (11), and the base plate (23) of casing (9) is provided with lip shape band (14).
6. children's obstructive sleep apnea low syndrome according to claim 5 is the Hypoxic Rats model intermittently, it is characterized in that: be provided with bearing (10) between leading screw (11) and the casing (9).
7. according to claim 1 or 2 or 4 or 6 described children's obstructive sleep apnea low syndromes Hypoxic Rats models at intermittence, it is characterized in that: funnel structure is adopted in the top of hypoxemia cabin (3), and the bottom of casing (9) is provided with case leg (12).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011202593380U CN202153926U (en) | 2011-07-21 | 2011-07-21 | Rat model for pediatric obstructive sleep apnea-hypopnea syndrome (OSAHS) intermittent hypoxia |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011202593380U CN202153926U (en) | 2011-07-21 | 2011-07-21 | Rat model for pediatric obstructive sleep apnea-hypopnea syndrome (OSAHS) intermittent hypoxia |
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| CN202153926U true CN202153926U (en) | 2012-03-07 |
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| CN2011202593380U Expired - Fee Related CN202153926U (en) | 2011-07-21 | 2011-07-21 | Rat model for pediatric obstructive sleep apnea-hypopnea syndrome (OSAHS) intermittent hypoxia |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102388810A (en) * | 2011-07-21 | 2012-03-28 | 西安交通大学医学院第二附属医院 | Intermittent hypoxia rat model for children obstructive sleep apnea hypopnea syndrome |
| CN103330603A (en) * | 2013-06-28 | 2013-10-02 | 温州医科大学 | Vertical lifting intermittent hypoxia rat and mouse feeding cabin |
| CN105853016A (en) * | 2016-04-28 | 2016-08-17 | 首都医科大学附属北京安贞医院 | Modeling device for mouse with OSAHS (obstructive sleep apnea hypopnea syndrome) |
-
2011
- 2011-07-21 CN CN2011202593380U patent/CN202153926U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102388810A (en) * | 2011-07-21 | 2012-03-28 | 西安交通大学医学院第二附属医院 | Intermittent hypoxia rat model for children obstructive sleep apnea hypopnea syndrome |
| CN103330603A (en) * | 2013-06-28 | 2013-10-02 | 温州医科大学 | Vertical lifting intermittent hypoxia rat and mouse feeding cabin |
| CN103330603B (en) * | 2013-06-28 | 2015-09-30 | 温州医科大学 | Vertical lift type intermittent hypoxia big and small mice feeding cabin |
| CN105853016A (en) * | 2016-04-28 | 2016-08-17 | 首都医科大学附属北京安贞医院 | Modeling device for mouse with OSAHS (obstructive sleep apnea hypopnea syndrome) |
| CN105853016B (en) * | 2016-04-28 | 2017-06-27 | 首都医科大学附属北京安贞医院 | Obstruction sleep apnea-hypopnea syndrome mouse model modeling device |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120307 Termination date: 20130721 |