CN105852130A - Preparation method of ginseng health care product and product of preparation method - Google Patents
Preparation method of ginseng health care product and product of preparation method Download PDFInfo
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- CN105852130A CN105852130A CN201610353626.XA CN201610353626A CN105852130A CN 105852130 A CN105852130 A CN 105852130A CN 201610353626 A CN201610353626 A CN 201610353626A CN 105852130 A CN105852130 A CN 105852130A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the field of health care food, in particular to a preparation method of a ginseng health care product and the product of the preparation method. The preparation method comprises the steps that ginseng stems and leaves and ginseng roots are separated, and ginsenoside is extracted from the ginseng stems and leaves and the ginseng roots separately; the ginseng roots are soaked with an ethanol solution and then extracted by adopting a percolation method to obtain ginseng root percolation liquid; the ginseng stems and leaves are decocted, adsorbed by a resin column and subjected to column washing and decoloring to obtain ginseng stem and leaf percolation liquid. By limiting various key parameters in the process, the ginseng utilization rate is increased, and the variety of ginsenoside is enriched. In addition, a new decoloring process and a new drying process are preferably selected, and therefore not only is the cost reduced, but also the ginsenoside loss is decreased.
Description
Technical field
The present invention relates to field of health care food, in particular to the preparation side of a kind of ginseng health product
Method and products thereof.
Background technology
Radix Ginseng is the dry root of Araliaceae Radix Ginseng (Panax ginseng C.A.Mey), is tradition name
Your Chinese medicine, begins to be loaded in first monograph on materia medica Shennong's Herbal of China.Its grower is referred to as " garden
Ginseng ", wild survivor is referred to as " SHANSHEN ".Radix Ginseng has that strongly invigorating primordial QI, multiple arteries and veins be admittedly de-, invigorating the spleen to benefit the lung, life
Tianjin, the function calmed the nerves, for weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, Tianjin is hindered
Thirsty, interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb, heart failure, heart source property not
The treatment of gram grade.Radix Ginseng is also extremely praised highly in Compendium of Material Medica by Li Shizhen (1518-1593 A.D.), it is believed that it can control " man
All deficient syndromes of woman ".For thousands of years, in Chinese herbal medicine, Radix Ginseng is all listed in " top grade ".After Radix Ginseng is usually used in more
Recover, regulate hormone, reduce blood glucose, physical strength reinforcing, control liver index regulating liver-QI functional health etc..
The chemical composition of Radix Ginseng is the most complicated, has saponin, volatile oil, saccharide and vitamin etc..Through the modern times
Medical science and pharmacological research prove, ginsenoside is the principle active component of Radix Ginseng, and it has the master of Radix Ginseng
Want physiologically active.
Ginsenoside (Ginsenoside, GS) is the principle active component of Radix Ginseng, the clearest and the most definite GS
Monomer there are about more than 40 kinds；Content in Radix Ginseng is about 4%.Numerous researchs show, it has relatively
High anti-tumor activity, to not normal cells side effect, joins with other chemotherapeutics (such as cisplatin)
Close application and have synergism.Ginsenoside is by modulate tumor cell generation cycle, Cell differentiation inducing activity
Antitumor action is played with apoptosis.Tumor cell induction is divided into normal cell be conducive to controlling to swell
Tumour development, inducing apoptosis of tumour cell forms apoptotic body after making cytoclasis, does not cause surrounding tissue
Inflammatory reaction.The research such as Popovich is thought, ginsenoside can promote withering of human leukemia cell
Dying, its approach is known each other with dexamethasone, is receptor-independent.
At present China to the extraction separation method of ginsenoside, preparation process, Anticancer Effect and Mechanism with
And the aspect such as clinical practice done numerous studies, and the new product of ginsenoside has been had to push city to
?.But in Ginseng Products in the market when extracting ginsenoside to the utilization rate of Radix Ginseng the most very
Low, and the content of ginsenoside is the highest.
In view of this, the special proposition present invention.
Summary of the invention
It is an object of the invention to provide the preparation method of a kind of ginseng health product, described preparation method
There is processing ease grasp, and ginsenoside is lost little, the technique effect that extraction efficiency is high.
The preparation method of a kind of ginseng health product, comprises the steps:
1), the leaves and stems of Radix Ginseng is separated with root, clean after drying stand-by respectively；
2) use percolation to carry out extraction after, Radix Ginseng ethanol solution infiltration being processed and obtain Radix Ginseng
Filter liquid；
3), Stem and leaf of Radix Ginseng is adsorbed by resin column after decocting, after washing post and decolouring, obtain people
Ginseng stem and leaf is filtered liquid；
4), combining step 2) and 3) obtain first filter liquid through filtration, concentrate, vacuum microwave drying
After obtain the total saponins that is dried；
5), described dry total saponins pulverized, sieve, obtain described ginseng health product after preparation.
Stem and leaf of Radix Ginseng portion is separated with root and extracts ginsenoside respectively by the application, improves Radix Ginseng
Utilization rate；And due to leaves and stems and ginsenoside's kind of root, various types of distribution the most difference,
Thus also improve content and the kind of ginsenoside.
Preferably, the preparation method of ginseng health product as above, in step 2) in, described second
Alcoholic solution infiltration particularly as follows:
It is 2～3mm that Radix Ginseng is crushed to particle diameter, with the ethanol solution that percentage by volume is 39～41%
Infiltration Radix Ginseng root 20～28 hours.
Preferably, the preparation method of ginseng health product as above, in step 2) in, described percolation
The operation of method specifically includes:
Ginseng raw material after infiltration is uniformly put into percolator and is compacted, is 37～39% by percentage by volume
Alcohol solution dipping 60～80 hours；Open bottom liquid outlet after immersion, be 37～39% by percentage by volume
Ethanol solution carry out percolation, flow velocity is 4～6mL/min kg, after going out to filter 12～13 hours will collect
To Radix Ginseng at the beginning of liquid of filtering individually deposit；
Flow velocity is adjusted to 3～5mL/min kg to effective ingredient fully leach percolation complete, by institute
Must continue to merge with liquid of filtering at the beginning of described Radix Ginseng after liquid of filtering concentrates and again be concentrated to give Radix Ginseng and filter liquid.
Preferably, the preparation method of ginseng health product as above, in step 3) in, described decoction
Process particularly as follows:
Heat with the clean water of quality 14～16 times after in advance Stem and leaf of Radix Ginseng is crushed to the fragment of 4～6mm
To 60～80 DEG C, put into Stem and leaf of Radix Ginseng, keep micro-state of rising after boiling, decoct 70～110 minutes, mistake
Filter, obtains the first decoction liquor and the first filtering residue；
In advance the clean water of Stem and leaf of Radix Ginseng quality 9～11 times is heated to 60～80 DEG C, puts into the first filtering residue,
Keep micro-state of rising after boiling, decoct 50～70 minutes, filter, obtain the second decoction liquor and the second filter
Slag；
In advance the clean water of Stem and leaf of Radix Ginseng quality 9～11 times is heated to 60～80 DEG C, puts into the first filtering residue,
Keep micro-state of rising after boiling, decoct 25～35 minutes, filter, obtain the 3rd decoction liquor and the 3rd filter
Slag；
Described first decoction liquor, the second decoction liquor and the 3rd decoction liquor are closed.
Preferably, the preparation method of ginseng health product as above, in step 3) in, described resin
Post absorption process particularly as follows:
The decoction liquor obtained after decocting crosses resin column, every 100kg Stem and leaf of Radix Ginseng corresponding 250～350kg
Resin；
The decoction liquor flow velocity that the resin of every 300kg is corresponding is 16～20kg/min.
Preferably, the preparation method of ginseng health product as above, in step 3) in, described in wash post
Operation particularly as follows:
After decoction liquor has crossed resin, successively with the distilled water and 2.5～3.5 times of resins with weight such as resins
Quality and percentage by volume be 58～62% ethanol solution wash post；The distillation that often resin of 300kg is corresponding
The flow velocity of water and ethanol solution is 7～10kg/min；Start when effluent occurs ethanol to collect eluting
Liquid；
In ejecting post with distilled water again after ethanol no longer flows out, ethanol is to the volume hundred of ethanol in eluent
Mark is reduced to stop collecting when 7～10%.
Preferably, the preparation method of ginseng health product as above, in step 3) in, described decolouring
Operation particularly as follows:
In the eluent dislocation return tank obtained during washing post, under agitation add and account for Stem and leaf of Radix Ginseng
Weight 8～the magnesium oxide of 12%, first 60～65 DEG C are heated to reflux 8～12 minutes, then 45～50 DEG C are heated back
Flow 15～25 minutes, cooling-sedimentation, take out clear liquid, filter and obtain Stem and leaf of Radix Ginseng and filter liquid.
Plant pigment is distributed widely in plant roots, stem, leaf, flower, fruit, can according to polarity difference
Being divided into fat-soluble pigment and water colo(u)r, fat-soluble pigment has chlorophyll, phylloxanthin, carotene
Deng, water colo(u)r has anthocyanidin.In plant extract production process, desolventing technology is the heaviest
The step wanted, otherwise will have a strong impact on outward appearance and the quality of product.
Magnesium oxide because having stronger shock-absorbing capacity, higher activity and absorbability, and process make
Not having the special performances such as corrosivity with safe and reliable, be very suitable for the decolouring of Radix Ginseng, it is former that it decolours
Reason is to utilize redox reaction, is broken by electrophilic effect and nucleation in acidity or alkaline medium
Bad chromophoric group.
Two steps are heated to reflux to increase on the basis of the retention rate increasing ginsenoside to greatest extent and take off
Color rate.
Preferably, the preparation method of ginseng health product as above, in step 3) in, described vacuum
The condition of microwave drying is:
60～80 DEG C, vacuum is not less than-0.085mPa, is dried to constant weight.
Traditional dry required time is the longest, speed is very slow, energy consumption is big, processing charges is high.Use
Microwave heating, can save the substantial amounts of energy, raising heating and the speed being dried, arid cycle significantly
Shortening, energy consumption reduces, and can improve work efficiency more than four times compared with conventional drying technique.
In addition, micro-wave vacuum equipment quality is good, and micro-wave vacuum equipment is extending food
Shelf-life, preserve the original local flavor of food and nutritional labeling, the physiologically active of reservation raw material, enhancing
Health food functional, improve the aspect such as added value of agricultural product.Compared with conventional method, added
The product quality of work has raising by a relatively large margin.Micro-wave vacuum equipment microwave also has sterilization, kills
Effect of bacterium, product safety health.Long shelf-life.For the application, faster drying time
Baking temperature evenly is remarkably improved effective content and the kind of ginsenoside.
Ginseng health product prepared by the preparation method of ginseng health product as above.
Preferably, the dosage form of described ginseng health product is granule or tablet.
Compared with prior art, the invention have the benefit that
1), the application Stem and leaf of Radix Ginseng portion is separated with root and extracts ginsenoside respectively, improve people
The utilization rate of ginseng, enriches the kind of ginsenoside.
2), by limiting Stem and leaf of Radix Ginseng portion and the different parameters in root extraction, it is greatly improved Radix Ginseng
The extraction efficiency of saponin.
3), use two step heating reflux methods to carry out desolventing technology, not only increase the percent of decolourization of Radix Ginseng,
And reduce the loss of ginsenoside.
4), use vacuum microwave drying to be dried process, not only reduce cost, add dry
Efficiency, and significantly increase effective content and the kind of ginsenoside.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but this area skill
Art personnel are it will be appreciated that the following example is merely to illustrate the present invention, and are not construed as limiting the present invention
Scope.Unreceipted actual conditions person in embodiment, the condition advised according to normal condition or manufacturer
Carry out.Agents useful for same or instrument unreceipted production firm person, being can be by commercially available purchase acquisition
Conventional products.
Embodiment 1
The preparation method of a kind of ginseng health product, comprises the steps:
1), the leaves and stems of Radix Ginseng is separated with root, clean after drying stand-by respectively；
2) use percolation to carry out extraction after, Radix Ginseng ethanol solution infiltration being processed and obtain Radix Ginseng
Filter liquid；
3), Stem and leaf of Radix Ginseng is adsorbed by resin column after decocting, after washing post and decolouring, obtain people
Ginseng stem and leaf is filtered liquid；
4), combining step 2) and 3) obtain first filter liquid through filtration, concentrate, vacuum microwave drying
After obtain the total saponins that is dried；
5), described dry total saponins pulverized, sieve, obtain described ginseng health product after preparation.
Embodiment 2
The preparation method of a kind of ginseng health product, comprises the steps:
1), the leaves and stems of Radix Ginseng is separated with root, clean after drying stand-by respectively；
2), by Radix Ginseng being crushed to particle diameter is 2mm, according to volume percent, uses percentage by volume
It it is the ethanol solution infiltration Radix Ginseng root 28 hours of 39%；
Ginseng raw material after infiltration is uniformly put into percolator and is compacted, is 37% by percentage by volume
Alcohol solution dipping 80 hours；Open bottom liquid outlet after immersion, be the ethanol of 37% by percentage by volume
Solution carries out percolation, and flow velocity is 4mL/min kg, at the beginning of the Radix Ginseng will collected after going out to filter 13 hours
Liquid of filtering individually is deposited；
Flow velocity is adjusted to 3mL/min kg to effective ingredient fully leach percolation complete, by gained
Continuous liquid of filtering merges with liquid of filtering at the beginning of described Radix Ginseng after concentrating and is again concentrated to give Radix Ginseng and filters liquid；
3) heat with the clean water of quality 14 times after, in advance Stem and leaf of Radix Ginseng is crushed to the fragment of 4mm
To 60 DEG C, put into Stem and leaf of Radix Ginseng, keep micro-state of rising after boiling, decoct 110 minutes, filter,
To the first decoction liquor and the first filtering residue；
In advance the clean water of Stem and leaf of Radix Ginseng quality 9 times is heated to 80 DEG C, puts into the first filtering residue, boiling
The micro-state of rising of rear holding, decocts 50 minutes, filters, obtains the second decoction liquor and the second filtering residue；
In advance the clean water of Stem and leaf of Radix Ginseng quality 9 times is heated to 80 DEG C, puts into the first filtering residue, boiling
The micro-state of rising of rear holding, decocts 25 minutes, filters, obtains the 3rd decoction liquor and the 3rd filtering residue；
Described first decoction liquor, the second decoction liquor and the 3rd decoction liquor are merged, after coarse filtration, carries out resin
Post adsorbs；
The decoction liquor (decoction liquor after merging) obtained after decocting crosses resin column, every 100kg Radix Ginseng
Stem and leaf correspondence 250kg resin；The decoction liquor flow velocity that the resin of every 300kg is corresponding is 16kg/min；
After having crossed resin, successively with the distilled water and the volume of 2.5 times of resin qualities with weight such as resins
Percent be 58% ethanol solution wash post；Distilled water that the resin of every 300kg is corresponding and ethanol solution
Flow velocity be 7kg/min；Start when effluent occurs ethanol to collect eluent；Treat that ethanol no longer flows
In ejecting post with distilled water again after going out, ethanol stops when reducing to 7% to the percentage by volume of ethanol in eluent
Only collect；
In the eluent dislocation return tank obtained during washing post, under agitation add and account for Stem and leaf of Radix Ginseng
The magnesium oxide of weight 8%, first 65 DEG C are heated to reflux 8 minutes, then 45 DEG C are heated to reflux 15 minutes, cold
But settle, take out clear liquid filter and filter and obtain Stem and leaf of Radix Ginseng and filter liquid；
4), combining step 2) and 3) liquid of filtering that obtains (Stem and leaf of Radix Ginseng filters liquid and Radix Ginseng is filtered liquid),
It is dried to constant weight under conditions of filtration, concentration and 80 DEG C of vacuums are not less than-0.085mPa
To the total saponins being dried；
5), described dry total saponins is pulverized, sieve, make granule after to obtain described people insured
Strong product.
Embodiment 3
The preparation method of a kind of ginseng health product, comprises the steps:
1), the leaves and stems of Radix Ginseng is separated with root, clean after drying stand-by respectively；
2), by Radix Ginseng being crushed to particle diameter is 3mm, with the ethanol solution leaching that percentage by volume is 41%
Profit Radix Ginseng root 20 hours；
Ginseng raw material's percolator after infiltration is uniformly put into percolator and is compacted, by percentage by volume is
The alcohol solution dipping of 39% 60 hours；Open bottom liquid outlet after immersion, be 39% by percentage by volume
Ethanol solution carry out percolation, flow velocity is 6mL/min kg, the people that will collect after going out to filter 12 hours
Liquid of filtering at the beginning of ginseng root is individually deposited；Flow velocity is adjusted to 5mL/min kg fully leach to effective ingredient and ooze
Till having filtered, merge with liquid of filtering at the beginning of described Radix Ginseng after continuous for gained liquid of filtering is concentrated and be again concentrated to give people
Ginseng root is filtered liquid；
3) heat with the clean water of quality 16 times after, in advance Stem and leaf of Radix Ginseng is crushed to the fragment of 6mm
To 80 DEG C, put into Stem and leaf of Radix Ginseng, keep micro-state of rising after boiling, decoct 70 minutes, filter, obtain
First decoction liquor and the first filtering residue；
In advance the clean water of Stem and leaf of Radix Ginseng quality 11 times is heated to 60 DEG C, puts into the first filtering residue, boiling
The micro-state of rising of rear holding, decocts 70 minutes, filters, obtains the second decoction liquor and the second filtering residue；
In advance the clean water of Stem and leaf of Radix Ginseng quality 11 times is heated to 60 DEG C, puts into the first filtering residue, boiling
The micro-state of rising of rear holding, decocts 35 minutes, filters, obtains the 3rd decoction liquor and the 3rd filtering residue；
Described first decoction liquor, the second decoction liquor and the 3rd decoction liquor are merged, after coarse filtration, carries out resin
Post adsorbs；
The decoction liquor (decoction liquor after merging) obtained after decocting crosses resin column, every 100kg Radix Ginseng
Stem and leaf correspondence 350kg resin；The decoction liquor flow velocity that the resin of every 300kg is corresponding is 20kg/min；
After having crossed resin, successively with the distilled water and the volume of 3.5 times of resin qualities with weight such as resins
Percent be 62% ethanol solution wash post；Distilled water that the resin of every 300kg is corresponding and ethanol solution
Flow velocity be 10kg/min；Start when effluent occurs ethanol to collect eluent；Treat that ethanol is no longer
In ejecting post with distilled water again after outflow, ethanol is to when in eluent, the percentage by volume of ethanol reduces to 10%
Stop collecting；
In the eluent dislocation return tank obtained during washing post, under agitation add and account for Stem and leaf of Radix Ginseng
The magnesium oxide of weight 12%, first 60 DEG C are heated to reflux 12 minutes, then 50 DEG C are heated to reflux 25 minutes,
Cooling-sedimentation, takes out clear liquid filter and filters and obtain Stem and leaf of Radix Ginseng and filter liquid；
4), combining step 2) and 3) liquid of filtering that obtains (Stem and leaf of Radix Ginseng filters liquid and Radix Ginseng is filtered liquid),
It is dried to constant weight under conditions of filtration, concentration and 60 DEG C of vacuums are not less than-0.085mPa
To the total saponins being dried；
5), described dry total saponins is pulverized, sieve, make tablet after obtain described Jinseng health-care
Product.
Embodiment 4
The preparation method of a kind of ginseng health product, comprises the steps:
1), the leaves and stems of Radix Ginseng is separated with root, clean after drying stand-by respectively；
2), by Radix Ginseng being crushed to particle diameter is 2.5mm, is the ethanol solution of 40% by percentage by volume
Infiltration Radix Ginseng root 24 hours；
Ginseng raw material's percolator after infiltration is uniformly put into percolator and is compacted, by percentage by volume is
The alcohol solution dipping of 38% 70 hours；Open bottom liquid outlet after immersion, be 38% by percentage by volume
Ethanol solution carry out percolation, flow velocity is 5mL/min kg, will collect after going out to filter 12.5 hours
Liquid of filtering at the beginning of Radix Ginseng is individually deposited；
Flow velocity is adjusted to 4mL/min kg to effective ingredient fully leach percolation complete, by gained
Continuous liquid of filtering merges with liquid of filtering at the beginning of described Radix Ginseng after concentrating and is again concentrated to give Radix Ginseng and filters liquid；
3) heat with the clean water of quality 15 times after, in advance Stem and leaf of Radix Ginseng is crushed to the fragment of 5mm
To 70 DEG C, put into Stem and leaf of Radix Ginseng, keep micro-state of rising after boiling, decoct 90 minutes, filter, obtain
First decoction liquor and the first filtering residue；
In advance the clean water of Stem and leaf of Radix Ginseng quality 10 times is heated to 70 DEG C, puts into the first filtering residue, boiling
The micro-state of rising of rear holding, decocts 60 minutes, filters, obtains the second decoction liquor and the second filtering residue；
In advance the clean water of Stem and leaf of Radix Ginseng quality 10 times is heated to 70 DEG C, puts into the first filtering residue, boiling
The micro-state of rising of rear holding, decocts 30 minutes, filters, obtains the 3rd decoction liquor and the 3rd filtering residue；
Described first decoction liquor, the second decoction liquor and the 3rd decoction liquor are merged, after coarse filtration, carries out resin
Post adsorbs；
The decoction liquor (decoction liquor after merging) obtained after decocting crosses resin column, every 100kg Radix Ginseng
Stem and leaf correspondence 300kg resin；The decoction liquor flow velocity that the resin of every 300kg is corresponding is 18kg/min；
After having crossed resin, successively with the distilled water and the volume of 3 times of resin qualities with weight such as resins
Percent be 60% ethanol solution wash post；Distilled water that the resin of every 300kg is corresponding and ethanol solution
Flow velocity be 8.5kg/min；Start when effluent occurs ethanol to collect eluent；Treat that ethanol is no longer
In ejecting post with distilled water again after outflow, ethanol is to when in eluent, the percentage by volume of ethanol reduces to 8.5%
Stop collecting；
In the eluent dislocation return tank obtained during washing post, under agitation add and account for Stem and leaf of Radix Ginseng
The magnesium oxide of weight 10%, first 63 DEG C are heated to reflux 10 minutes, then 47 DEG C are heated to reflux 20 minutes,
Cooling-sedimentation, takes out clear liquid filter and filters and obtain Stem and leaf of Radix Ginseng and filter liquid；
4), combining step 2) and 3) liquid of filtering that obtains (Stem and leaf of Radix Ginseng filters liquid and Radix Ginseng is filtered liquid),
It is dried to constant weight under conditions of filtration, concentration and 70 DEG C of vacuums are not less than-0.085mPa
To the total saponins being dried；
5), described dry total saponins is pulverized, sieve, make granule after to obtain described people insured
Strong product.
Embodiment 5
The preparation method of a kind of ginseng health product, comprises the steps:
1), the leaves and stems of Radix Ginseng is separated with root, clean after drying stand-by respectively；
2), by Radix Ginseng being crushed to particle diameter is 2.5mm, is the ethanol solution of 40% by percentage by volume
Moistening, wait raw materials used the most moistening after put into container, airtight placement 24 hours, wait medical material abundant
Absorb ethanol, without hard-core time, can load in percolator.
When ginseng raw material after infiltration loads percolator should uniformly, put in batches, every batch put into after all use
The uniform tabletting of waddy；Also Radix Ginseng can be loaded in cloth bag, then direct plunge in percolator, after input
Balance compacting, do not interspace, after finishing, with weight, Radix Ginseng is compressed.It is subsequently added and is equivalent to Radix Ginseng
Measure 4 times 38% ethanol, ethanol add before first the valve of percolator bottom liquid outlet is opened half,
Then add ethanol from percolator top, when ethanol flows out from head piece, close valve, by flow out
Ethanol is poured in percolator from top again, and the ethanol of addition should be higher than that Radix Ginseng top layer 50cm, airtight immersion
72 hours.
Ginseng raw material can start percolator after 72 hours soak, and can open bottom liquid outlet, flow velocity control
System, in 1 kilogram of medical material, outflow 5mL per minute, (going out to filter about 12～13 hours), prepares simultaneously
One tank suitable Radix Ginseng input amount 4～38% ethanol of 5 times, need at any time from supplementing above during percolation
Leaching solvent, makes solvent remain higher than Radix Ginseng top layer more than 20cm, when that collects 85% first filters
During liquid, liquid of this just being filtered individually is deposited；Liquid of just filtering should be the clear liquor of reddish brown, the continuous flow velocity oozed
Also should control within every kilogram of medical material 5mL per minute, be 3mL per minute if desired, in Herba Lycianthis Biflorae material
Effective ingredient fully leach percolation complete till, residue discards.
The continuous liquid of filtering collected is heated filtration, then squeezes in concentration tank, cryoconcentration, steam pressure
It is maintained at below 1.5kg, after ethanol reclaims, uses vacuum drawn moisture content so that it is become flowing soaking paste,
Being subsequently adding the first liquid of filtering of initially preservation, again concentrate, the standard of concentrated solution is that water content is left 50%
The right side, finger stretches into wherein sticky sense, and when finger is taken out, liquid becomes wire, but has certain flowing
Property.
3) heat with the clean water of quality 15 times after, in advance Stem and leaf of Radix Ginseng is crushed to the fragment of 5mm
To 70 DEG C, put into Stem and leaf of Radix Ginseng, keep micro-state of rising after boiling, decoct 90 minutes, filter, obtain
First decoction liquor and the first filtering residue；
In advance the clean water of Stem and leaf of Radix Ginseng quality 10 times is heated to 70 DEG C, puts into the first filtering residue, boiling
The micro-state of rising of rear holding, decocts 60 minutes, filters, obtains the second decoction liquor and the second filtering residue；
In advance the clean water of Stem and leaf of Radix Ginseng quality 10 times is heated to 70 DEG C, puts into the first filtering residue, boiling
The micro-state of rising of rear holding, decocts 30 minutes, filters, obtains the 3rd decoction liquor and the 3rd filtering residue；
Described first decoction liquor, the second decoction liquor and the 3rd decoction liquor are merged, after coarse filtration, carries out resin
Post adsorbs；
The decoction liquor obtained after decocting crosses resin column, every 100kg Stem and leaf of Radix Ginseng correspondence 300kg resin；
The decoction liquor flow velocity that the resin of every 300kg is corresponding is 18kg/min；
After having crossed resin, successively with the distilled water and the volume of 3 times of resin qualities with weight such as resins
Percent be 60% ethanol solution wash post；Distilled water that the resin of every 300kg is corresponding and ethanol solution
Flow velocity be 8.5kg/min；Start to collect effluent when eluent occurs ethanol taste；Again with distillation
Water eject ethanol to concentration of alcohol in eluent in post be 10% (percentage by volume) below, wash post complete
Finish immediately with warm water backwash to washing liquid without alcohol taste and clear colorless.Water in post is not
Drain.
In the eluent dislocation return tank obtained during washing post, under agitation add and account for Stem and leaf of Radix Ginseng
The magnesium oxide of amount 10%, first 63 DEG C are heated to reflux 10 minutes, then 47 DEG C are heated to reflux 20 minutes, cold
But settle, take out clear liquid filter and filter and obtain Stem and leaf of Radix Ginseng and filter liquid；
4), combining step 2) and 3) liquid of filtering that obtains (Stem and leaf of Radix Ginseng filters liquid and Radix Ginseng is filtered liquid),
It is dried to constant weight under conditions of filtration, concentration and 70 DEG C of vacuums are not less than-0.085mPa
To the total saponins being dried；
5), described dry total saponins is pulverized, cross 100 mesh sieves, make tablet after obtain described people
Ginseng health product.
Experimental example 1
Two-step bleaching method compares with a step decoloring method.
Discoloration method in embodiment 5 is changed into: the eluent dislocation backflow obtained during post being washed
In tank, under agitation adding the magnesium oxide accounting for Stem and leaf of Radix Ginseng amount 10%, 60 DEG C are refluxed 30 minutes, cooling
Sedimentation, takes out clear liquid filter and filters and obtain Stem and leaf of Radix Ginseng and filter liquid；In this, as comparative example and embodiment 5
The Stem and leaf of Radix Ginseng obtained liquid of filtering compares.
Table 1 two-step bleaching method compares with a step decoloring method
| Sample ID | Percent of decolourization (%) | Ginsenoside Re's retention rate (%) |
| Embodiment 5 Stem and leaf of Radix Ginseng is filtered liquid | 69% | 88.9% |
| Comparative example | 46% | 80.2% |
Note:
Absorbance × 100% before percent of decolourization=(absorbance after absorbance-decolouring before decolouring)/decolouring；
Ginsenoside Re's content before ginsenoside Re's content/decolouring after ginsenoside Re's retention rate=decolouring
× 100%
As known from Table 1, by the decoloration process improved, the application obtains higher percent of decolourization and people
Ginseng saponin Re retention rate.
Experimental example 2
Drying means compares.
After vacuum microwave drying method in embodiment 5 replaces with the first baking of routine respectively, dry in the sun is done
Dry, and natural drying seasoning, other parameters are with embodiment 5；Concrete parameter and effect such as table 2 institute
Show:
Table 2 different dry drying method compares
| Sample | Embodiment 5 | First dry in the sun after baking | Natural drying |
| Baking temperature (DEG C) | 70 | 70,20～30 | 20～30 |
| Drying time (h) | 1 | 98 | 150 |
| Moisture (%) | 7.6 | 11.8 | 11.6 |
| Rh2 content (%) | 18.4 | 9.16 | 9.22 |
Experimental example 3
By the finished product obtained in the application difference embodiment and according to Publication No. CN103783387A
Ginseng Products prepared by method (embodiment 1) compares as a comparison case, and result is as shown in table 3:
Table 3 Ginseng Products parameter compares
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that and do not carrying on the back
May be made that in the case of the spirit and scope of the present invention many other change and amendment.Therefore,
This means all these changes including belonging in the scope of the invention in the following claims and repair
Change.
Claims (10)
1. the preparation method of a ginseng health product, it is characterised in that comprise the steps:
1), the leaves and stems of Radix Ginseng is separated with root, clean after drying stand-by respectively；
2) use percolation to carry out extraction after, Radix Ginseng ethanol solution infiltration being processed and obtain Radix Ginseng
Filter liquid；
3), Stem and leaf of Radix Ginseng is adsorbed by resin column after decocting, after washing post and decolouring, obtain people
Ginseng stem and leaf is filtered liquid；
4), combining step 2) and 3) obtain first filter liquid through filtration, concentrate, vacuum microwave drying
After obtain the total saponins that is dried；
5), described dry total saponins pulverized, sieve, obtain described ginseng health product after preparation.
2. the preparation method of ginseng health product as claimed in claim 1, it is characterised in that in step
2) in, described ethanol solution infiltration particularly as follows:
It is 2～3mm that Radix Ginseng is crushed to particle diameter, with the ethanol solution that percentage by volume is 39～41%
Infiltration Radix Ginseng root 20～28 hours.
3. the preparation method of ginseng health product as claimed in claim 1, it is characterised in that in step
2), in, the operation of described percolation specifically includes:
Ginseng raw material after infiltration is uniformly put into percolator and is compacted, is 37～39% by percentage by volume
Alcohol solution dipping 60～80 hours；Open bottom liquid outlet after immersion, be 37～39% by percentage by volume
Ethanol solution carry out percolation, flow velocity is 4～6mL/min kg, after going out to filter 12～13 hours will collect
To Radix Ginseng at the beginning of liquid of filtering individually deposit；
Flow velocity is adjusted to 3～5mL/min kg to effective ingredient fully leach percolation complete, by institute
Must continue to merge with liquid of filtering at the beginning of described Radix Ginseng after liquid of filtering concentrates and again be concentrated to give Radix Ginseng and filter liquid.
4. the preparation method of ginseng health product as claimed in claim 1, it is characterised in that in step
3) in, described decoction process particularly as follows:
Heat with the clean water of quality 14～16 times after in advance Stem and leaf of Radix Ginseng is crushed to the fragment of 4～6mm
To 60～80 DEG C, put into Stem and leaf of Radix Ginseng, keep micro-state of rising after boiling, decoct 70～110 minutes, mistake
Filter, obtains the first decoction liquor and the first filtering residue；
In advance the clean water of Stem and leaf of Radix Ginseng quality 9～11 times is heated to 60～80 DEG C, puts into the first filtering residue,
Keep micro-state of rising after boiling, decoct 50～70 minutes, filter, obtain the second decoction liquor and the second filter
Slag；
In advance the clean water of Stem and leaf of Radix Ginseng quality 9～11 times is heated to 60～80 DEG C, puts into the first filtering residue,
Keep micro-state of rising after boiling, decoct 25～35 minutes, filter, obtain the 3rd decoction liquor and the 3rd filter
Slag；
Described first decoction liquor, the second decoction liquor and the 3rd decoction liquor are closed.
5. the preparation method of ginseng health product as claimed in claim 1, it is characterised in that in step
3) in, described resin column absorption process particularly as follows:
The decoction liquor obtained after decocting crosses resin column, every 100kg Stem and leaf of Radix Ginseng corresponding 250～350kg
Resin；
The decoction liquor flow velocity that the resin of every 300kg is corresponding is 16～20kg/min.
6. the preparation method of ginseng health product as claimed in claim 1, it is characterised in that in step
3) in, described in wash post operation particularly as follows:
After decoction liquor has crossed resin, successively with the distilled water and 2.5～3.5 times of resins with weight such as resins
Quality and percentage by volume be 58～62% ethanol solution wash post；The distillation that often resin of 300kg is corresponding
The flow velocity of water and ethanol solution is 7～10kg/min；Start when effluent occurs ethanol to collect eluting
Liquid；
In ejecting post with distilled water again after ethanol no longer flows out, ethanol is to the volume hundred of ethanol in eluent
Mark is reduced to stop collecting when 7～10%.
7. the preparation method of ginseng health product as claimed in claim 1, it is characterised in that in step
3) in, the operation of described decolouring particularly as follows:
In the eluent dislocation return tank obtained during washing post, under agitation add and account for Stem and leaf of Radix Ginseng
Weight 8～the magnesium oxide of 12%, first 60～65 DEG C are heated to reflux 8～12 minutes, then 45～50 DEG C are heated back
Flow 15～25 minutes, cooling-sedimentation, take out clear liquid, filter and obtain Stem and leaf of Radix Ginseng and filter liquid.
8. the preparation method of ginseng health product as claimed in claim 1, it is characterised in that in step
3), in, the condition of described vacuum microwave drying is:
60～80 DEG C, vacuum is not less than-0.085mPa, is dried to constant weight.
9. the ginseng health product that prepared by preparation method described in any one of claim 1～8.
10. ginseng health product as claimed in claim 9, it is characterised in that described ginseng health product
Dosage form be granule or tablet.
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Application publication date: 20160817 |