CN105832697A - Preparation method and application of vitamin D3 calcium soft capsule - Google Patents
Preparation method and application of vitamin D3 calcium soft capsule Download PDFInfo
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- CN105832697A CN105832697A CN201610242151.7A CN201610242151A CN105832697A CN 105832697 A CN105832697 A CN 105832697A CN 201610242151 A CN201610242151 A CN 201610242151A CN 105832697 A CN105832697 A CN 105832697A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
Abstract
The invention discloses a preparation method and an application of a vitamin D3 calcium soft capsule. The preparation method for the vitamin D3 calcium soft capsule comprises the following steps: raw material pre-treatment, primary treatment, squeezing, leaching and purifying, filler preparation, glue solution preparation and pelleting. The vitamin D3 calcium soft capsule provided by the invention contains rich trace elements and active substances, can be used for safely and effectively treating diseases such as arthralgia and night sweat, has calcium supplementing effect, has relatively good healthcare effect, and has a good application prospect.
Description
Technical field
The present invention relates to field of medicaments, particularly relate to a kind of vitamin D3The preparation method and applications of calcium soft capsule.
Background technology
Calcium is the pith constituting human body, and in the various physiological activities and biochemical process of body, plays an important role to sustaining life.The 2% of the calcium about percentage of liveweight of the total amount in human body, but 1% is present in blood, soft tissue sick participation maintenance heart and the normal activity of muscle, neural normal regulating and conduction, the solidification overall process of blood and the multiple enzymatic activity of human body.The minor variations of blood calcium can directly affect the distribution of intraor extracellular calcium concentration so that causing a series of physiology and pathological change.Such as there will be the diseases such as hypoimmunity, cramp, arthralgia, insomnia and dreamful sleep, weak asthenia, loss of appetite, night sweat during people's calcium deficiency.
Human body can be by obtaining in food to the demand of calcium, but the absorption process that calcium is in vivo is affected by total rudder factor, even if containing substantial amounts of calcareous in food, also there will be the situation that absorbance is the highest, such as oxalic acid in plant food is easily and calcium is combined into the salt of slightly solubility, thus reduces the absorption of calcium.Vitamin D3Human body is the necessary nutrient that sustains life, is one of the Chinese medicine regulatory factor of alcium and phosphor metabolization, maintains calcium and the normal level of phosphorus, the human body absorption to calcium can be promoted, be the supplementation product that current utilization is the highest.
Calcium supplement health care product in the market is of a great variety, such as vitamin D3Calcium soft capsule is easier to absorb than general dosage form calcium, its biological utilisation is made to substantially exceed other calcium preparation in fluid form, its content of this type of compound soft capsule preparation is the oil suspension with soybean oil as disperse medium, calcareous material is typically chosen calcium carbonate, and function singleness, it is impossible to the disease that comprehensive solution calcium deficiency causes.
Summary of the invention
In view of this, the invention provides a kind of vitamin D3The preparation method and applications of calcium soft capsule.
The technological means that the present invention uses is as follows:
First aspect, the invention provides a kind of vitamin D3The preparation method of calcium soft capsule, comprises the following steps:
Pretreatment of raw material: by Misgurni anguillicaudati, the Hypophthalmichthys molitrix bone section of breaking into respectively, be cooled to room temperature after baking, grinds, and prepares Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I；
Just process: described Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I, water, alkaline protease and flavor protease mixing, 5h～7h is hydrolyzed at 50 DEG C～65 DEG C, add Radix Rehmanniae Preparata, the Radix Astragali, Poria and Fructus Lycii, stir, at a temperature of 65 DEG C～80 DEG C, heating 20min～30min, then be dried, i.e. prepare Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal II；
Squeezing: sunflower seed and described Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal II being mixed, cold press prepares the first fluid；
Extraction purifies: described first fluid is heated in pot for solvent extraction 60 DEG C～80 DEG C, adds activated carbon stirring, heated and stirred 30min～60min, stands, separates, take upper strata fluid and prepare the second fluid；
Prepared by implant: described second fluid, vitamin D3With Cera Flava mix and blend, it is heated to 60 DEG C～70 DEG C, after stirring, crosses colloid mill, after sieve, prepare implant；
Prepared by glue: add purified water, glycerol in glue tank, be heated to 70 DEG C～80 DEG C, adds titanium dioxide and sticks with paste liquid and gelatin, prepares glue after stirring；
Pill: described implant and described glue are carried out pelleting in pellet press, shape after pelleting, be dried i.e. prepare vitamin D3Calcium soft capsule.
Preferably, described Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I is 1:8～12 with the mass ratio of water, and the enzyme activity of described alkaline protease is 0.8IU/g～8IU/g, and the enzyme activity of described flavor protease is 13IU/g～65IU/g.
Preferably, described Radix Rehmanniae Preparata with described Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I mass ratio is: 0.25～1:1, the described Radix Astragali and described Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I mass ratio are 0.1～0.5:1, described Poria and described Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I mass ratio are 0.15～0.25:1, and described Fructus Lycii and described Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I mass ratio are 0.15～0.25:1.
Second aspect, the invention provides a kind of vitamin D3Calcium soft capsule, for using a kind of vitamin D as described in relation to the first aspect3Prepared by the preparation method of calcium soft capsule.
The third aspect, present invention also offers vitamin D as described in relation to the first aspect3Vitamin D prepared by the preparation method of calcium soft capsule3Calcium soft capsule application in the medicine of preventing and treating night sweat.
Fourth aspect, present invention also offers vitamin D as described in relation to the first aspect3Vitamin D prepared by the preparation method of calcium soft capsule3Calcium soft capsule application in the medicine preventing and treating arthralgia.
Detailed description of the invention
The following is the principle to the present invention and feature is described, example is served only for explaining the present invention, is not intended to limit the scope of the present invention.
Embodiment 1
A kind of vitamin D3The preparation method of calcium soft capsule, comprises the following steps:
Raw material has: 100g Misgurni anguillicaudati, 100g Hypophthalmichthys molitrix bone, and 0.8IU/g alkaline protease (adds alkaline protease with every 1g Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I, until enzymatic activity is 0.8IU/g), 13IU/g flavor protease (adds alkaline protease with every 1g Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I, until enzymatic activity is 13IU/g), 50g Radix Rehmanniae Preparata, the 20g Radix Astragali, 30g Poria, 30g Fructus Lycii, 150g sunflower seed, 210g Oleum Helianthi, 0.62mg vitamin D3, 2g Cera Flava, 300g gelatin, 135g glycerol, 3g titanium dioxide.
Pretreatment of raw material: by Misgurni anguillicaudati, the Hypophthalmichthys molitrix bone section of breaking into respectively, toasts at 80 DEG C, is cooled to room temperature, then grinds to form Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I after baking；
Just process: add water, alkaline protease and flavor protease at described Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I, mixture is 1:8 with the mass ratio of water, 5h is hydrolyzed at 50 DEG C, add Radix Rehmanniae Preparata, the Radix Astragali, Poria and Fructus Lycii, stir, at a temperature of 65 DEG C, heat 20min, it is dried again, i.e. prepares Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal II；
Squeezing: sunflower seed and Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal II being mixed, cold press prepares the first fluid at 10 DEG C；
Extraction purifies: the first fluid is heated in pot for solvent extraction 60 DEG C, adds activated carbon (with the Mass Calculation of the first fluid) stirring of 4%, heated and stirred 30min, stands, separate, take upper strata fluid and prepare the second fluid；
Prepared by implant: the second fluid, Oleum Helianthi and vitamin D3In water-bath type warm ingredients tank, stir 10min, add Cera Flava, be heated to 60 DEG C, cross colloid mill (JM80 type, Langfang Tongyong Machinery Manufacturing Co., Ltd. produces) after stirring 10min, be stirred for 2h, cross 100 mesh sieves, prepare implant；
Prepared by glue: pre-transconversion into heat glue tank (RJHA-200L type, Wenzhou Rongji Capsule Medicinal Chemical Equipment Co., Ltd. produces), 300g purified water, glycerol is added in glue tank, it is heated to 70 DEG C of dissolvings, add ground titanium dioxide and stick with paste liquid, add gelatin, after stirring 25min, during when the temperature to 70 DEG C, open vacuum pump, under the conditions of vacuum is 0.08mpa, glue is carried out evacuation 30min, bubble is eliminated to liquid level stabilizing, after crossing 100 mesh sieves, banishes 60 DEG C of insulations in glue bucket, prepare glue；
Pill: (be shaped as ellipse, loading amount 500mg/ grain, glue bucket (glue) insulation degree 55-65 DEG C by processing parameter, temperature of charge is room temperature, controls loading amount at 500mg ± 37.5mg), implant and glue are operated in pellet press (RGY6-20 type, Changzheng Tianmin High Science & Technology Co., Ltd., Beijing produces) the upper standard operating procedure pressing pelleting；After pelleting, semi-finished product enter rotating cage industry type by conveyer belt, and setting temperature is 20～25 DEG C, relative humidity less than 40%, time 2h；By having gone up the soft gelatin capsule of dish after sizing, push drying shed and be dried, the temperature of drying shed, humidity, it is ensured that temperature 24-28 DEG C, relative humidity 20-25%, in drying shed, it is dried soft gelatin capsule, is dried 22～24h, i.e. prepares vitamin D3Calcium soft capsule.
Embodiment 2
A kind of vitamin D3The preparation method of calcium soft capsule, comprises the following steps:
Raw material has: 100g Misgurni anguillicaudati, 100g Hypophthalmichthys molitrix bone, and (every 1g Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I adds alkaline protease to 4IU/g alkaline protease, until enzymatic activity is 4IU/g), 40IU/g flavor protease (every 1g Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I adds alkaline protease, until enzymatic activity is 40IU/g), 100g Radix Rehmanniae Preparata, the 50g Radix Astragali, 40g Poria, 40g Fructus Lycii, 150g sunflower seed, 210g Oleum Helianthi, 0.62mg vitamin D3, 2g Cera Flava, 300g gelatin, 135g glycerol, 3g titanium dioxide.
Pretreatment of raw material: by Misgurni anguillicaudati, the Hypophthalmichthys molitrix bone section of breaking into respectively, toasts at 90 DEG C, is cooled to room temperature, then grinds to form Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I after baking,；
Just pretreatment: add water, alkaline protease and flavor protease in Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I, mixture is 1:10 with the solid-to-liquid ratio of water, 6h is hydrolyzed at 55 DEG C, add Radix Rehmanniae Preparata, the Radix Astragali, Poria and Fructus Lycii, stir, at a temperature of 70 DEG C, heat 25min, it is dried again, i.e. prepares Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal II；
Squeezing: sunflower seed and Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal II being mixed, cold press prepares the first fluid at 5 DEG C；
Extraction purifies: the first fluid is heated in pot for solvent extraction 70 DEG C, adds activated carbon (with the Mass Calculation of the first fluid) stirring of 5%, heated and stirred 45min, stands, separate, take upper strata fluid and prepare the second fluid；
Prepared by implant: the second fluid, Oleum Helianthi and vitamin D3In water-bath type warm ingredients tank, stir 10min, add Cera Flava, be heated to 65 DEG C, cross colloid mill (JM80 type, Langfang Tongyong Machinery Manufacturing Co., Ltd. produces) after stirring 10min, be stirred for 2h, cross 100 mesh sieves, prepare implant；
Prepared by glue: pre-transconversion into heat glue tank (RJHA-200L type, Wenzhou Rongji Capsule Medicinal Chemical Equipment Co., Ltd. produces), 300g purified water, glycerol is added in glue tank, it is heated to 75 DEG C of dissolvings, add ground titanium dioxide and stick with paste liquid, add gelatin, after stirring 25min, during when the temperature to 70 DEG C, open vacuum pump, under the conditions of vacuum is 0.08mpa, glue is carried out evacuation 30min, bubble is eliminated to liquid level stabilizing, after crossing 100 mesh sieves, banishes 60 DEG C of insulations in glue bucket, prepare glue；
Pill: (be shaped as ellipse, loading amount 500mg/ grain, glue bucket (glue) guarantor's temperature 60 C by processing parameter, temperature of charge is room temperature, controls loading amount at 500mg ± 37.5mg), implant and glue are operated in pellet press (RGY6-20 type, Changzheng Tianmin High Science & Technology Co., Ltd., Beijing produces) the upper standard operating procedure pressing pelleting；After pelleting, semi-finished product enter rotating cage industry type by conveyer belt, and setting temperature is 25 DEG C, relative humidity less than 40%, time 2h；By having gone up the soft gelatin capsule of dish after sizing, push drying shed and be dried, the temperature of drying shed, humidity, it is ensured that temperature 25 DEG C, relative humidity 25%, in drying shed, it is dried soft gelatin capsule, is dried 24h, i.e. prepares vitamin D3Calcium soft capsule.
Embodiment 3
A kind of vitamin D3The preparation method of calcium soft capsule, comprises the following steps:
Raw material has: 100g Misgurni anguillicaudati, 100g Hypophthalmichthys molitrix bone, and (every 1g Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I adds alkaline protease to 8IU/g alkaline protease, until enzymatic activity is 8IU/g), 65IU/g flavor protease (every 1g Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I adds alkaline protease, until enzymatic activity is 65IU/g), 200g Radix Rehmanniae Preparata, the 100g Radix Astragali, 50g Poria, 50g Fructus Lycii, 150g sunflower seed, 210g Oleum Helianthi, 0.62mg vitamin D3, 2g Cera Flava, 300g gelatin, 135g glycerol, 3g titanium dioxide.
Pretreatment of raw material: by Misgurni anguillicaudati, the Hypophthalmichthys molitrix bone section of breaking into respectively, toasts at 100 DEG C, is cooled to room temperature, then grinds to form Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I after baking；
Hypophthalmichthys molitrix bone pretreatment: add water, alkaline protease and flavor protease in Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I, mixture is 1:12 with the solid-to-liquid ratio of water, 7h is hydrolyzed at 65 DEG C, add Radix Rehmanniae Preparata, the Radix Astragali, Poria and Fructus Lycii, stir, at a temperature of 80 DEG C, heat 30min, it is dried again, i.e. prepares Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal II；
Squeezing: sunflower seed and Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal II being mixed, cold press prepares the first fluid at 0 DEG C；
Extraction purifies: the first fluid is heated in pot for solvent extraction 80 DEG C, adds activated carbon (with the Mass Calculation of the first fluid) stirring of 6%, heated and stirred 60min, stands, separate, take upper strata fluid and prepare the second fluid；
Prepared by implant: the second fluid, Oleum Helianthi and vitamin D3In water-bath type warm ingredients tank, stir 10min, add Cera Flava, be heated to 70 DEG C, cross colloid mill (JM80 type, Langfang Tongyong Machinery Manufacturing Co., Ltd. produces) after stirring 10min, be stirred for 2h, cross 100 mesh sieves, prepare implant；
Prepared by glue: pre-transconversion into heat glue tank (RJHA-200L type, Wenzhou Rongji Capsule Medicinal Chemical Equipment Co., Ltd. produces), 300g purified water, glycerol is added in glue tank, it is heated to 80 DEG C of dissolvings, add ground titanium dioxide and stick with paste liquid, add gelatin, after stirring 25min, during when the temperature to 70 DEG C, open vacuum pump, under the conditions of vacuum is 0.08mpa, glue is carried out evacuation 30min, bubble is eliminated to liquid level stabilizing, after crossing 100 mesh sieves, banishes 60 DEG C of insulations in glue bucket, prepare glue；
Pill: (be shaped as ellipse, loading amount 500mg/ grain, glue bucket (glue) guarantor's temperature 60 C by processing parameter, temperature of charge is room temperature, controls loading amount at 500mg ± 37.5mg), implant and glue are operated in pellet press (RGY6-20 type, Changzheng Tianmin High Science & Technology Co., Ltd., Beijing produces) the upper standard operating procedure pressing pelleting；After pelleting, semi-finished product enter rotating cage industry type by conveyer belt, and setting temperature is 25 DEG C, relative humidity less than 40%, time 2h；By having gone up the soft gelatin capsule of dish after sizing, push drying shed and be dried, the temperature of drying shed, humidity, it is ensured that temperature 25 DEG C, relative humidity 25%, in drying shed, it is dried soft gelatin capsule, is dried 24h, i.e. prepares vitamin D3Calcium soft capsule.
Embodiment 4
1, clinical trial
Clinical symptoms crowd: this group crowd totally 50 example, 18 years old age～70 years old, male 25 examples, female 25 example, equal clinical diagnosis is calcium deficiency the symptom having arthralgia, insomnia and dreamful sleep, inappetence, night sweat, and this group crowd divides 4 groups at random, and packet situation is shown in Table 1.
Further, corresponding respectively the vitamin D prepared by embodiment 1～3 is taken for 1～3 group3Calcium soft capsule, takes each 1, every day 1 time, one after each meal, avoid pungent, avoid edible Herba Spinaciae, beans etc., take continuously 8 months, advise life, diet, daily life regular.
Further, gummy shark board vitamin D is taken for 4 groups3Soft capsule, takes each 1, every day 1 time, one after each meal, avoid pungent, avoid edible Herba Spinaciae, beans etc., take continuously 8 months, advise life, diet, daily life regular.
Further, do not take any medicine for 5 groups, advise life, diet, daily life regular.
Table 1
2, curative effect determinate standard:
1) clinical effective: arthralgia disappears, total sleep time 8h～10h, and appetite is normal, without night sweat；
2) clinical effective: arthralgia alleviates, total sleep time 6h～8h, and appetite has taken a turn for the better, occur that inappetence, night sweat number of times and amount of sweat reduce once in a while；
3) clinical invalid: arthralgia does not alleviates, < 6h, inappetence continue night sweat to total sleep time.
2, Comparison of therapeutic table: be shown in Table 2
Table 2
| Group | Number of cases | Effective | Effectively | Invalid |
| 1 group | 10 | 6 | 3 | 1 |
| 2 groups | 10 | 8 | 2 | 0 |
| 3 groups | 10 | 7 | 2 | 1 |
| 4 groups | 10 | 0 | 0 | 10 |
For further illustrating beneficial effects of the present invention, the invention provides following model case:
A, Xing, man, 50 years old, the course of disease 2 years.Without any inducement sense right carpal joint pain before 2 years, and there is night sweat in nighttime sleep, and amount of sweat is more, falls asleep relatively slow, and number of times of getting up in the night to urinate is more.Start with the above-mentioned embodiment of the present invention 2 preparation capsule, each 1, every day 1 time, one after each meal.Taking effect after taking 5 months, after 10 months, symptom substantially alleviates, and after 14 months, symptom is wholly absent.Follow up a case by regular visits to 1 year have no above-mentioned symptom resume combustion.
B, Deng, female, 26 years old, build was become thin, poor sleeping quality and have night sweat phenomenon, and length of one's sleep every day is less than 4 hours, and swelling band tingle occurs in leg joint, the course of disease 1 year.Starting the capsule with the embodiment of the present invention 2 preparation, each 1, every day 1 time, take 3 months symptoms and alleviated, be clearly better after 6 months, after 8 months, symptom is wholly absent.Follow up a case by regular visits to 1 year have no above-mentioned symptom resume combustion.
3, composition detection:
Take a vitamin D prepared by embodiment 23Calcium soft capsule (500g/ grain), detects following data, is shown in Table 3
Table 3
| Components Name | Content | Components Name | Content |
| Calcium | 239.0mg | TCA soluble nitrogen | 61.1mg/mL |
| Vitamin E | 80.5mg | Riboflavin | 30.3mg |
| Vitamin A | 70.1mg | Phosphorus | 110.7mg |
| Vitamin C | 35.9mg | Zinc | 2.8mg |
| Potassium | 211.7mg | Selenium | 51.4mg |
In sum, vitamin D provided by the present invention is used3Calcium soft capsule contains abundant trace element and active substance, can safely and effectively treat the disease such as arthralgia, night sweat, not only has effect of supplement calcium, also has preferable health-care effect, have a good application prospect.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. done, within should be included in the scope of protection of the invention.
Claims (6)
1. a vitamin D3The preparation method of calcium soft capsule, it is characterised in that comprise the following steps:
Pretreatment of raw material: by Misgurni anguillicaudati, the Hypophthalmichthys molitrix bone section of breaking into respectively, be cooled to room temperature after baking, grinds, system
Obtain Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I；
Just process: described Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I, water, alkaline protease and flavor protease mixing, at 50 DEG C
～at 65 DEG C, hydrolyze 5h～7h, add Radix Rehmanniae Preparata, the Radix Astragali, Poria and Fructus Lycii, stir, at 65 DEG C
～at a temperature of 80 DEG C, heat 20min～30min, then be dried, i.e. prepare Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal II；
Squeezing: sunflower seed and described Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal II being mixed, cold press prepares the first fluid；
Extraction purifies: described first fluid is heated in pot for solvent extraction 60 DEG C～80 DEG C, adds activated carbon stirring,
Heated and stirred 30min～60min, stand, and separates, takes upper strata fluid and prepare the second fluid；
Prepared by implant: described second fluid, vitamin D3With Cera Flava mix and blend, it is heated to 60 DEG C～70 DEG C,
Cross colloid mill after stirring, after sieve, prepare implant；
Prepared by glue: add purified water, glycerol in glue tank, be heated to 70 DEG C～80 DEG C, add titanium dioxide
Titanium sticks with paste liquid and gelatin, prepares glue after stirring；
Pill: described implant and described glue are carried out in pellet press pelleting, shapes after pelleting, is dried
I.e. prepare vitamin D3Calcium soft capsule.
2. vitamin D as claimed in claim 13The preparation method of calcium soft capsule, it is characterised in that described
Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I is 1:8～12 with the mass ratio of water, and the enzyme activity of described alkaline protease is 0.8IU/g～8
IU/g, the enzyme activity of described flavor protease is 13IU/g～65IU/g.
3. vitamin D as claimed in claim 13The preparation method of calcium soft capsule, it is characterised in that described
Radix Rehmanniae Preparata with described Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I mass ratio is: 0.25～1:1, the described Radix Astragali and described Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal
I mass ratio is 0.1～0.5:1, and described Poria and described Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I mass ratio are 0.15～0.25:1,
Described Fructus Lycii and described Misgurni anguillicaudati Hypophthalmichthys molitrix bone meal I mass ratio are 0.15～0.25:1.
4. a vitamin D3Calcium soft capsule, it is characterised in that for use such as claims 1 to 3 any one
Vitamin D3Prepared by the preparation method of calcium soft capsule.
5. vitamin D as described in claims 1 to 33Vitamin D prepared by the preparation method of calcium soft capsule3
Calcium soft capsule application in the medicine of preventing and treating night sweat.
6. vitamin D as described in claims 1 to 33Vitamin D prepared by the preparation method of calcium soft capsule3
Calcium soft capsule application in the medicine preventing and treating arthralgia.
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Application publication date: 20160810 |