CN105831365A - Coffee containing ginkgo leaf extract product - Google Patents

Abstract

The invention discloses a coffee containing ginkgo leaf extract, which is composed of the following raw materials in parts by weight: 0.5-1 part of solid dispersion of ginkgo leaf extract, 10-20 parts of instant coffee powder; the ginkgo leaf extract The solid dispersion is prepared from ginkgo biloba extract and edible collagen hydrolyzate at a mass ratio of 1:10‑16. The coffee containing ginkgo biloba extract of the present invention uses instant coffee as a base, while maintaining the flavor and effect of coffee, uses edible collagen hydrolyzate as a carrier material, and prepares a solid dispersion of ginkgo biloba extract from ginkgo biloba extract. Improve the bioavailability of Ginkgo biloba extract, which has the advantages of instant dissolution and easy absorption, and has a synergistic effect with Ginkgo biloba extract, which has the effects of improving blood circulation, softening blood vessels, lowering blood fat, lowering blood pressure, protecting gastric mucosa and anti-ulcer , is a healthy coffee that integrates leisure and health care.

Description

A coffee with ginkgo biloba extract

technical field

The invention belongs to the field of health drinks, in particular to coffee containing ginkgo biloba extract.

Background technique

Ginkgo biloba is the dried leaf of Ginkgo biloba L., a plant of the family Ginkgoaceae. It is sweet, bitter, astringent, flat, and has the effects of astringing the lungs, relieving asthma, promoting blood circulation, removing blood stasis, and relieving pain. It is used clinically to improve Microcirculation, prevention and treatment of cardiovascular and cerebrovascular diseases, etc. Domestic research on the chemical constituents and pharmacological effects of Ginkgo biloba began in the 1960s, and the preparations developed successively were used clinically and achieved good results.

The chemical composition of Ginkgo biloba is very complex. So far, more than 160 compounds have been found in Ginkgo biloba, but the most important active ingredients are flavonoids and ginkgolides; Ginkgo flavonoids can resist free radicals and inhibit lipid peroxidation , expand blood vessels, improve cerebral arteries, and have preventive effects on diseases such as senile dementia, hypertension, coronary heart disease, arteriosclerosis, and brain dysfunction; ginkgolides are platelet activating factor antagonists, and have a certain degree of anti-inflammatory and neuroprotective effects , has potential application value in the treatment of asthma, endotoxin shock, organ transplant rejection, cardiovascular and cerebrovascular diseases; in addition, there are organic acids, phenols, polyprenols, proanthocyanidins and nutritional ingredients. Ginkgo biloba extract has various functions such as reducing capillary permeability, dilating coronary vessels, increasing coronary and cerebrovascular flow, lowering blood lipids, scavenging free radicals, and anti-oxidation. It is widely used as pharmaceutical raw materials and food additives.

As a refreshing drink, coffee is becoming more and more popular among Chinese people. It has the functions of stimulating the cerebral cortex, relieving fatigue, and improving mental state. However, coffee can stimulate the central nervous system and blood circulation system. Palpitations, arrhythmia, elevated blood pressure, gastrointestinal discomfort and other allergic reactions. With the improvement of living standards and the acceleration of the pace of work, coffee drinking is becoming more and more popular, and there are more and more requirements for the functionalization and diversification of coffee.

Contents of the invention

The invention provides a kind of coffee containing Ginkgo biloba extract. While maintaining the flavor and function of coffee, edible collagen hydrolyzate is used as carrier material, and Ginkgo biloba extract is used to prepare Ginkgo biloba extract solid dispersion, which significantly improves the quality of Ginkgo biloba. The bioavailability of the leaf extract, which has the characteristics of instant dissolution and easy absorption

The purpose of the present invention is achieved through the following technical solutions:

A coffee containing ginkgo leaf extract is composed of the following raw materials in parts by weight: 0.5-1 part of solid dispersion of ginkgo leaf extract, 10-20 parts of instant coffee powder;

The solid dispersion of Ginkgo biloba extract is prepared from Ginkgo biloba extract and edible collagen hydrolyzate at a mass ratio of 1:10-16.

The molecular weight of the edible collagen hydrolyzate is 5000-13000.

The solid dispersion of the ginkgo leaf extract is prepared by a solvent-spray drying method.

The solvent-spray drying method is as follows: the ginkgo biloba extract and the edible collagen hydrolyzate are co-dissolved in the solvent under stirring, the density is adjusted to 1.2-1.3, and the air flow rate is 0.4-1.3m/min, the pressure is 0.4-0.6MPa 1. Spray-drying at an air inlet temperature of 160-180°C until the water content is ≤5.0%, to obtain a solid dispersion of ginkgo biloba extract.

The solvent is water or ethanol.

Beneficial effects of the present invention:

1. the present invention contains the coffee of ginkgo biloba extract, with instant coffee as matrix, while keeping coffee local flavor and effect, with edible collagen protein hydrolyzate as carrier material, ginkgo leaf extract is prepared ginkgo biloba extract solid dispersion , significantly improves the bioavailability of Ginkgo biloba extract, has the advantages of instant dissolution and easy absorption, and plays a synergistic effect with Ginkgo biloba extract, which can improve blood circulation, soften blood vessels, lower blood fat, lower blood pressure, protect gastric mucosa and resist ulcers It is a healthy coffee that integrates leisure and health care.

2. The coffee containing Ginkgo biloba extract of the present invention adopts the solvent-spray drying method to prepare the solid dispersion of Ginkgo biloba extract, which can minimize the decomposition of the effective components of Ginkgo biloba extract in the processing process, and has no harmful solvent residue, and has broad application prospects.

detailed description

The technical scheme of the present invention will be described below with specific examples, but the scope of protection of the present invention is not limited thereto, and any amendments, equivalent replacements, quantitative changes and improvements etc. made within the spirit and principles of the present invention should be Included within the protection scope of the present invention.

The edible collagen hydrolyzate used in the following examples was produced by a chemical manufacturing company in Hubei.

The ginkgo leaf extract used in the following examples was purchased from a pharmaceutical company in Shandong, containing 24.8% flavonol glycosides and 6.2% ginkgo lactone.

Example 1

A coffee containing ginkgo leaf extract is composed of the following raw materials in parts by weight: 0.5 parts of solid dispersion of ginkgo leaf extract, 20 parts of instant coffee powder;

The solid dispersion of Ginkgo biloba extract is prepared from Ginkgo biloba extract and edible collagen hydrolyzate at a mass ratio of 1:10.

The molecular weight of the edible collagen hydrolyzate is 5000-6000.

The solid dispersion of the ginkgo leaf extract is prepared by a solvent-spray drying method.

The solvent-spray drying method is as follows: Ginkgo biloba extract and edible collagen hydrolyzate are co-dissolved in the solvent under stirring, and the density is adjusted to 1.2. Spray drying is carried out under the conditions until the water content is less than or equal to 5.0%, and the solid dispersion of the ginkgo leaf extract is obtained.

The solvent is water.

Preparation method: mix the solid dispersion of ginkgo biloba extract and instant coffee powder in proportion, sterilize, and pack in 15g/bag.

Example 2

A coffee containing ginkgo leaf extract is composed of the following raw materials in parts by weight: 0.6 parts of solid dispersion of ginkgo leaf extract, 18 parts of instant coffee powder;

The solid dispersion of Ginkgo biloba extract is prepared from Ginkgo biloba extract and edible collagen hydrolyzate at a mass ratio of 1:12.

The molecular weight of the edible collagen hydrolyzate is 6000-7000.

The solid dispersion of the ginkgo leaf extract is prepared by a solvent-spray drying method.

The solvent-spray drying method is as follows: Ginkgo biloba extract and edible collagen hydrolyzate are co-dissolved in the solvent under stirring, and the density is adjusted to 1.3. Spray drying is carried out under the conditions until the water content is less than or equal to 5.0%, and the solid dispersion of the ginkgo leaf extract is obtained.

The solvent is ethanol.

The preparation method is the same as in Example 1.

Example 3

A coffee containing ginkgo leaf extract is composed of the following raw materials in parts by weight: 0.8 parts of solid dispersion of ginkgo leaf extract, 15 parts of instant coffee powder;

The solid dispersion of Ginkgo biloba extract is prepared from Ginkgo biloba extract and edible collagen hydrolyzate at a mass ratio of 1:14.

The molecular weight of the edible collagen hydrolyzate is 7000-9000.

The solid dispersion of the ginkgo leaf extract is prepared by a solvent-spray drying method.

The solvent-spray drying method is as follows: Ginkgo biloba extract and edible collagen hydrolyzate are co-dissolved in the solvent under stirring, and the density is adjusted to 1.2. Spray drying is carried out under the conditions until the water content is less than or equal to 5.0%, and the solid dispersion of the ginkgo leaf extract is obtained.

The solvent is water.

The preparation method is the same as in Example 1.

Example 4

A coffee containing ginkgo leaf extract is composed of the following raw materials in parts by weight: 0.9 parts of solid dispersion of ginkgo leaf extract, 13 parts of instant coffee powder;

The solid dispersion of Ginkgo biloba extract is prepared from Ginkgo biloba extract and edible collagen hydrolyzate at a mass ratio of 1:12.

The molecular weight of the edible collagen hydrolyzate is 9000-11000.

The solid dispersion of the ginkgo leaf extract is prepared by a solvent-spray drying method.

The solvent-spray-drying method is as follows: Ginkgo biloba extract and edible collagen hydrolyzate are co-dissolved in the solvent under stirring, and the density is adjusted to 1.3. Spray drying is carried out under the conditions until the water content is less than or equal to 5.0%, and the solid dispersion of the ginkgo leaf extract is obtained.

The solvent is ethanol.

The preparation method is the same as in Example 1.

Example 5

A coffee containing ginkgo leaf extract is composed of the following raw materials in parts by weight: 1 part of solid dispersion of ginkgo leaf extract, 10 parts of instant coffee powder;

The solid dispersion of Ginkgo biloba extract is prepared from Ginkgo biloba extract and edible collagen hydrolyzate at a mass ratio of 1:16.

The molecular weight of the edible collagen hydrolyzate is 1100-13000.

The solid dispersion of the ginkgo leaf extract is prepared by a solvent-spray drying method.

The solvent-spray-drying method is as follows: Ginkgo biloba extract and edible collagen hydrolyzate are co-dissolved in the solvent under stirring, and the density is adjusted to 1.2. Spray drying is carried out under the conditions until the water content is less than or equal to 5.0%, and the solid dispersion of the ginkgo leaf extract is obtained.

The solvent is ethanol.

The preparation method is the same as in Example 1.

Comparative example 1

A coffee is composed of the following raw materials in parts by weight: 0.8 part of ginkgo biloba extract and 15 parts of instant coffee powder.

Preparation method: mix ginkgo biloba extract and instant coffee powder in proportion, sterilize, and pack in 15g/bag.

Comparative example 2

A kind of coffee is made up of the following raw materials by weight: 0.8 parts of edible collagen protein hydrolyzate, 15 parts of instant coffee powder;

The molecular weight of the edible collagen hydrolyzate is 7000-9000.

Preparation method: Mix edible collagen hydrolyzate and instant coffee powder in proportion, sterilize, and pack in 15g/bag.

sensory evaluation

Randomly select the test crowd of 5 age stages respectively within the whole city, each age group respectively 240, be divided into 8 groups at random, every group of 30, to the coffee that the embodiment of the present invention 1-5 prepares, The coffee prepared in Comparative Example 1-2 and the coffee in Comparative Example 3 (15g/bag of pure instant coffee powder) were evaluated for flavor function. The evaluation criteria for flavor function are shown in Table 1, and the results of flavor function evaluation are shown in Table 2.

Table 1 Flavor sensory evaluation criteria

Table 2 Flavor sensory evaluation results

clinical information

General information: 270 patients with stable angina pectoris with coronary heart disease and hyperlipidemia and hypertension were selected. The patients were treated with Ginkgo Leaf Dispersible Tablets for a long time. They were randomly divided into 1-5 experimental groups and 1-4 control groups. The general information of the patients was compared and the difference No statistical significance (P>0.05), comparable.

Therapeutic method: experimental group 1-5 drinks the coffee that contains ginkgo leaf extract that embodiment 1-5 prepares, and control group 1-2 drinks the coffee that comparative example 1-2 prepares, and control group 3 drinks the pure instant coffee of 15g/bag powder, the control group 4 took ginkgo leaves (equivalent to 19.2 mg of ginkgo flavonol glycosides and 4.8 mg of ginkgo lactone) according to the prescribed dose, once a day in the morning and once in the evening, and the cycle was one month.

During the experiment, all the people in each group stopped taking other drugs and nutrients.

Efficacy evaluation criteria:

Significantly effective: increased physical fitness, full of energy, no symptoms of chest pain and heartache, blood lipids and blood pressure decreased;

Effective: Physical fitness has increased, mental status has improved significantly, no chest obstruction, heartaches have decreased, blood lipids and blood pressure have stabilized;

Ineffective: no improvement.

Treatment results: The treatment results are shown in Table 3.

Table 3 Treatment Results

It can be known from Table 3 that the number of effective cases, effective cases and effective rate of the coffee containing ginkgo biloba extract prepared in Examples 1-5 of the present invention are significantly higher than those of the control group 1-4.

The coffee containing ginkgo biloba extract of the present invention uses instant coffee as a substrate, while maintaining the coffee flavor and effect, uses edible collagen hydrolyzate as a carrier material, and prepares a solid dispersion of ginkgo biloba extract from ginkgo biloba extract. Improve the bioavailability of Ginkgo biloba extract, which has the advantages of instant dissolution and easy absorption, and has a synergistic effect with Ginkgo biloba extract, which has the effects of improving blood circulation, softening blood vessels, lowering blood fat, lowering blood pressure, protecting gastric mucosa and anti-ulcer , is a healthy coffee that integrates leisure and health care.

Claims (5)

1. A kind of coffee containing Ginkgo biloba extract, is characterized in that, is made up of the raw material of following weight portion: Ginkgo biloba extract solid dispersion 0.5-1 part, instant coffee powder 10-20 part; The solid dispersion of Ginkgo biloba extract is prepared from Ginkgo biloba extract and edible collagen hydrolyzate at a mass ratio of 1:10-16. 2. The coffee according to claim 1, characterized in that the molecular weight of the edible collagen hydrolyzate is 5000-13000. 3. The coffee according to claim 1, characterized in that, the solid dispersion of Ginkgo biloba extract is prepared by a solvent-spray drying method. 4. The coffee according to claim 3, characterized in that, the solvent-spray drying method is: the Ginkgo biloba extract and the edible collagen hydrolyzate are stirred and co-dissolved in the solvent, and the density is adjusted to 1.2-1.3, Under the conditions of air velocity 0.4-1.3m/min, pressure 0.4-0.6MPa, and air inlet temperature 160-180°C, carry out spray drying until the water content is ≤5.0%, to obtain the solid dispersion of Ginkgo biloba extract. 5. The coffee according to claim 4, wherein the solvent is water or ethanol.