CN101732492A - Adinandra nitida leaf flavone oral tablet and preparation method - Google Patents
Adinandra nitida leaf flavone oral tablet and preparation method Download PDFInfo
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- CN101732492A CN101732492A CN200910214128A CN200910214128A CN101732492A CN 101732492 A CN101732492 A CN 101732492A CN 200910214128 A CN200910214128 A CN 200910214128A CN 200910214128 A CN200910214128 A CN 200910214128A CN 101732492 A CN101732492 A CN 101732492A
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- adinandra nitida
- adinandra
- oral tablet
- nitida leaf
- flavone
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Abstract
The invention discloses an adinandra nitida leaf flavone oral tablet and a preparation method which belong to the technical field of the processing of health-care products. The adinandra nitida leaf flavone oral tablet takes flavonoid extracted from adinandra nitida leaves as a main raw material, comprises the following components according to the weight ratio in a formula: 100-500g of adinandra nitida leaf, 10-150g of sweetening agent, 1-25g of citric acid, 1-50g of dextrin, 0-25g of acacia and 0.3-2.5g of magnesium stearate, and is prepared by tabletting. A product is in a slight green-yellow colour and has sweet mouth feel. The adinandra nitida flavone oral tablet does not need to be taken with water, can be quickly dissolved when encountering saliva in the oral cavity, is convenient to take, is quick to absorb and can give full play to the preventing and treating function of a flavone compound contained in the adinandra nitida leaves to the health care of a human body and diseases.
Description
Technical field
The invention belongs to the health product processing technique field, being specifically related to the flavone compound that is contained in the Adinandra nitida leaf is the oral buccal tablet and the preparation method of primary raw material.
Background technology
Adinandra nitida (Adinandra nitida Merr.ex H.L.Li) is that Theaceae (Theaceae) Yang Tong belongs to (Adinandra) plant, mainly is distributed in the provinces and regions such as Guangxi, Guangdong, Guizhou of China, aboundresources.Among the peoplely utilize this young leaf of plant to make health tea to be used to prevent and treat diseases such as various inflammation, nameless gall and wound, all receive satisfactory effect and have no side effect.Recent studies show that the major physiological active component in the Adinandra nitida leaf is a flavone compound, and general flavone content surpasses 20%.Flavone compound is one of nutrient of needed by human, can not synthesize in the human body, can only absorb from food.Pharmaceutical research shows, flavone compound has living radical superfluous in tangible antioxidation, blood fat reducing, the removing body and prevents and treats coronary heart disease, hypertension, effect such as antibiotic.China's Ministry of Public Health this flavonoids of official approval is a effective component in the health food.
At " food research and development " 2007 the 3rd phases 118～120 pages of flavonoidss that disclose in the LC-MS evaluation Adinandra nitida leaf, in " chemistry of forest product and industry " the 1st phase in 2008 6～10 pages of evaluation and antioxidant activity researchs thereof that disclose Adinandra nitida leaf flavonoid extract, show that the flavone compound that is contained in the Adinandra nitida leaf is mainly camellin A, next contains a spot of camellin B and apigenin.At present still very low to the development and use degree of Adinandra nitida leaf, be mainly elementary Tea Processing.Research prepares the flavonoid product of high added value from Adinandra nitida leaf cheap and easy to get, have higher realistic meaning.
Summary of the invention
The objective of the invention is with the flavone compound that is contained in the Adinandra nitida leaf is primary raw material, a kind of taking convenience is provided, do not need water delivery service, meeting saliva in the oral cavity can dissolve rapidly, the crowd who is fit to dysphagias such as old man, child uses, absorb soon flavone oral buccal tablet and preparation method that bioavailability is high.
The present invention is achieved like this; its prescription comprises following component and weight ratio: 100～500g Adinandra nitida leaf; 10～150g sweeting agent; 1～25g citric acid; 1～50g dextrin; 0～25g arabic gum; 0.3～2.5g magnesium stearate; its preparation method is: take by weighing Adinandra nitida leaf 100～500g by recipe ratio; adding 10～50 times of water gaging heating decocts; seethed with excitement 30～60 minutes; vacuum filtration while hot; filtering residue adds 10～50 times of water gaging ebuillition of heated after 30～60 minutes again; sucking filtration while hot; twice filtrate merging is cooled to room temperature; can find has partially crystallizable to separate out at chamber wall and container bottom; filtrate changed in 0～4 ℃ of refrigerator placed 5～10 hours, place 1000～5000rpm to isolate the pistac precipitate in centrifugal 10～30 minutes, precipitate was placed 85～100 ℃ of baking oven inner dryings 1 hour; add 10～150g sweeting agent again; 1～25g citric acid, 1～50g dextrin, 0～25g arabic gum mix homogeneously; water spray places the pelletize of sulfuration bed comminutor for binding agent; particulate size is to be advisable by 16 mesh sieves, and the granule that makes is processed into oral with difformity and pattern with rotary tablet machine after adding magnesium stearate 0.3～2.5g.
Sweeting agent of the present invention can be one or more in Sorbitol, xylitol, sucrose, the glucose.
The present invention is to be primary raw material with the Adinandra nitida leaf, and contained flavone compound is mainly camellin A, a small amount of camellin B and apigenin.
The present invention is an oral buccal tablet, and its composition is natural product, and is harmless, can take for a long time, has treatment oral ulcer, stomachache, relieves the effect of alcohol physiological functions such as blood pressure lowering.
The specific embodiment
Be elaborated below in conjunction with embodiment:
Embodiment 1:
Take by weighing Adinandra nitida leaf 100g; adding 10 times of water gaging heating decocts; seethed with excitement 30 minutes; vacuum filtration while hot; filtering residue adds 10 times of water gaging ebuillition of heated after 30 minutes again; sucking filtration while hot; twice filtrate merging is cooled to room temperature; can find has partially crystallizable to separate out at chamber wall and container bottom; filtrate changed in 0 ℃ of refrigerator placed 5 hours, place 1000rpm to isolate the pistac precipitate in centrifugal 30 minutes, precipitate was placed 85 ℃ of baking oven inner dryings 1 hour; the sucrose that adds 10g again; the citric acid of 1g, the dextrin mix homogeneously of 1g is sprayed water and is vulcanized the pelletize of bed comminutor for binding agent places; particulate size is to be advisable by 16 mesh sieves; after the granule that makes adds magnesium stearate 0.3g, be processed into oral with circle with rotary tablet machine, every Weight control is about 0.3g; the buccal tablet sieve that presses removes fine powder, is finished product in the damp-prrof packing of packing into.
Embodiment 2:
Take by weighing Adinandra nitida leaf 100g; adding 30 times of water gaging heating decocts; seethed with excitement 30 minutes; vacuum filtration while hot; filtering residue adds 30 times of water gaging ebuillition of heated after 30 minutes again; sucking filtration while hot; twice filtrate merging is cooled to room temperature; can find has partially crystallizable to separate out at chamber wall and container bottom, filtrate is changed in 4 ℃ of refrigerators placed 8 hours, places 5000rpm to isolate the pistac precipitate in centrifugal 10 minutes; precipitate was placed 100 ℃ of baking oven inner dryings 1 hour; the sucrose that adds 30g again, the citric acid of 2g, the dextrin of 5g; the arabic gum mix homogeneously of 3g; water spray places the pelletize of sulfuration bed comminutor for binding agent, and particulate size is to be advisable by 16 mesh sieves, after the granule that makes adds magnesium stearate 0.3g; be processed into oral with rotary tablet machine with circle and Adinandra nitida plant pattern; every Weight control is about 0.3g, and the buccal tablet sieve that presses removes fine powder, is finished product in the damp-prrof packing of packing into.
Embodiment 3:
Take by weighing Adinandra nitida leaf 0.5kg; adding 50 times of water gaging heating decocts; seethed with excitement 60 minutes; vacuum filtration while hot; filtering residue adds 50 times of water gaging ebuillition of heated after 60 minutes again; sucking filtration while hot; twice filtrate merging is cooled to room temperature, and can find has partially crystallizable to separate out at chamber wall and container bottom, filtrate is changed in 4 ℃ of refrigerators placed 10 hours; place 5000rpm to isolate the pistac precipitate in centrifugal 30 minutes; precipitate was placed 100 ℃ of baking oven inner dryings 1 hour, add Sorbitol 100g again, glucose 50g; citric acid 25g; dextrin 50g, arabic gum 25g mix homogeneously is sprayed water and is vulcanized the pelletize of bed comminutor for binding agent places; particulate size is to be advisable by 16 mesh sieves; the granule that makes is processed into oral with circle and plant flavone printed words with rotary tablet machine after adding magnesium stearate 2.5g, and every Weight control is about 0.3g; the buccal tablet sieve that presses removes fine powder, is finished product in the damp-prrof packing of packing into.
The above record only for using the embodiment of the technology of the present invention content, anyly is familiar with modification that this operator uses the present invention to do, variation, all belonged to the claim that the present invention advocates, and be not limited to cited embodiment.
Claims (4)
1. Adinandra nitida leaf flavone oral tablet is characterized in that it is made by the raw material of following weight ratio: 100～500g Adinandra nitida leaf, 10～150g sweeting agent, 1～25g citric acid, 1～50g dextrin, 0～25g arabic gum, 0.3～2.5g magnesium stearate.
2. described a kind of Adinandra nitida leaf flavone oral tablet preparation method of claim 1; it is characterized in that processing step is: take by weighing the Adinandra nitida leaf by recipe ratio; adding 10～50 times of water gaging heating decocts; seethed with excitement 30～60 minutes; vacuum filtration while hot; filtering residue adds 10～50 times of water gaging ebuillition of heated after 30～60 minutes again; sucking filtration while hot; twice filtrate merging is cooled to room temperature; can find has partially crystallizable to separate out at chamber wall and container bottom; filtrate changed in 0～4 ℃ of refrigerator placed 5～10 hours, place 1000～5000rpm to isolate the pistac precipitate in centrifugal 10～30 minutes, precipitate was placed 85～100 ℃ of baking oven inner dryings 1 hour; add sweeting agent by recipe ratio; citric acid, dextrin, arabic gum mix homogeneously; water spray places the pelletize of sulfuration bed comminutor for binding agent; particulate size is to be advisable by 16 mesh sieves, and the granule that makes is processed into oral with difformity and pattern with rotary tablet machine after adding magnesium stearate by recipe ratio.
3. a kind of Adinandra nitida leaf flavone oral tablet as claimed in claim 1 is characterized in that described sweeting agent is one or more in Sorbitol, xylitol, sucrose, the glucose.
4. a kind of Adinandra nitida leaf flavone oral tablet as claimed in claim 1 is characterized in that it is that the flavone compound that obtains with extraction in the Adinandra nitida leaf is a primary raw material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102141287A CN101732492B (en) | 2009-12-24 | 2009-12-24 | Adinandra nitida leaf flavone oral tablet and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102141287A CN101732492B (en) | 2009-12-24 | 2009-12-24 | Adinandra nitida leaf flavone oral tablet and preparation method |
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| Publication Number | Publication Date |
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| CN101732492A true CN101732492A (en) | 2010-06-16 |
| CN101732492B CN101732492B (en) | 2011-11-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2009102141287A Expired - Fee Related CN101732492B (en) | 2009-12-24 | 2009-12-24 | Adinandra nitida leaf flavone oral tablet and preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102218103A (en) * | 2011-06-16 | 2011-10-19 | 广西壮族自治区中医药研究院 | Application of extractive of adinandra nitida leaves to preparation of anti-inflammatory analgesia medicament |
| CN103191308A (en) * | 2013-01-18 | 2013-07-10 | 六安同济生生物科技有限公司 | Compound Dendrobium huoshanense-cistanche-glossy ganoderma buccal tablet and production process thereof |
| CN108690027A (en) * | 2018-06-15 | 2018-10-23 | 广州大学 | A kind of 2- difluoro methylenes substituted pyrimidines and [1,2-a]Benzimidazole compound and its preparation and application |
| CN111484473A (en) * | 2020-06-16 | 2020-08-04 | 青岛科技大学 | Apigenin extraction method and apigenin buccal tablet |
-
2009
- 2009-12-24 CN CN2009102141287A patent/CN101732492B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102218103A (en) * | 2011-06-16 | 2011-10-19 | 广西壮族自治区中医药研究院 | Application of extractive of adinandra nitida leaves to preparation of anti-inflammatory analgesia medicament |
| CN102218103B (en) * | 2011-06-16 | 2013-07-17 | 广西壮族自治区中医药研究院 | Application of extractive of adinandra nitida leaves in preparation of anti-inflammatory analgesia medicament |
| CN103191308A (en) * | 2013-01-18 | 2013-07-10 | 六安同济生生物科技有限公司 | Compound Dendrobium huoshanense-cistanche-glossy ganoderma buccal tablet and production process thereof |
| CN108690027A (en) * | 2018-06-15 | 2018-10-23 | 广州大学 | A kind of 2- difluoro methylenes substituted pyrimidines and [1,2-a]Benzimidazole compound and its preparation and application |
| CN108690027B (en) * | 2018-06-15 | 2019-09-27 | 广州大学 | A kind of 2- difluoro methylene substituted pyrimidines simultaneously [1,2-a] benzimidazole compound and its preparation and application |
| CN111484473A (en) * | 2020-06-16 | 2020-08-04 | 青岛科技大学 | Apigenin extraction method and apigenin buccal tablet |
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| Publication number | Publication date |
|---|---|
| CN101732492B (en) | 2011-11-02 |
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Granted publication date: 20111102 Termination date: 20131224 |