KR101716005B1 - A method for preparing the powder preparation of Kyung-ok-go containing abundant active-ingredient - Google Patents

Abstract

The present invention relates to a process for producing a mushroom powder containing a large amount of an active ingredient.

Description

[0001] The present invention relates to a method for preparing a mushroom powder containing a large amount of an active ingredient,

The present invention relates to a process for producing a mushroom powder containing a large amount of an active ingredient.

[Literature 1] Metaphorical Information Extension, Young Lim, p440-443, 1998

[Literature 2] Information Supervision, Shin Min-gyo, Metaphorical Contest of Daehae, Yeonglim, pp906-909, 1998

[Literature 3] Information Supervision, Shin Min-gyo, Metaphorical Context of the Context, Young Lim, pp41-43, 1998

The present invention relates to a process for producing a mushroom powder containing a large amount of an active ingredient.

Gyeongok-gyo (고 膏) is recorded in Dong-bok-gong (东 醫 寶 鑑) and 약 합 합 합 합 방 (藥) . It is not exaggerated to say that Kyong-Okgok itself is a feature of Korean oriental medicine, considering that the Oriental medicine of ubiquitous medicine is vast, but considering that it is settled on the basis of the weight of the weight of diagnosis and treatment in Oriental medicine .

As for the efficacy of Kyeongokgyo, In other words, it replenishes all the 虛 失 证 (the Horseshoe) by filling the 精 (regular chung) and 髓 (marrow), helping the ch'i 气 and helping the nurturing, And heals all sorts of diseases. It is said to fill the jeans, to see the number, to blacken the hair, to make the teeth bloom, and to have the manshin to get rid of the white pox, and the mind is getting better and the five is faithful, the gray hair is again blackened, The pace of the pacemaker is as fast as a horse, and the efficacy of this medicine can not be said to be such that it does not become hungry or thirsty all day if it eats two or three times a day.

Therefore, our ancestors constantly pursued life extension, longevity and disease - free prescription as one of the curing methods, and utilized Kio - Ok, which is made of the most noble medicines.

Therefore, it recharges the vestibuli, that is, the vagina, and also controls the cerebrospinal fluid and bone marrow, regulates the theoretical matrix of the 阴气 and the ovary, nourishes the natural sex, rejuvenates and rejuvenates, (100 loss), and it is said that it will remove the hundred disease.

The present invention relates to a process for producing gyeongokgyo powder, which is an invention relating to a process for producing gyeongokgok by an acid treatment so as to preserve the pharmacological action of the gyeongokgyo and enjoy without any sense of resistance.

The prescription composition of Gyeongokgyo consists of ginseng, which is the representative medicinal material of Korea, and the medicine and honey, which are extracted from the roots of pine tree, which is a symbol of Korea, and ginseng. These four medicines work together to balance the efficacy of each medication.

Panax ginseng CA Meyer) is a perennial herbaceous plant belonging to the genus Ginseng (Araliaceae). It is one of the representative medicinal crops mainly used in oriental medicine. After 4 to 6 years of harvesting according to the post-harvest processing method, the unprocessed raw ginseng is peeled off from fresh ginseng and 4-6 years old ginseng, dried naturally in the sun or dried by hot air at 60 ° C or less, Ginseng, steamed with steam for 4-6 years, without peel, is classified into red ginseng.

Ginseng is Korean ginseng (Panax ginseng), Firewood (Panax quinquefoliaHowever,Panax notoginseng), VietnamPanax vietnamensis),Panax japonicus), Panax Elegantor (Panax elegatior), Panax Wanian (Panax wangianus), Panax bisfinatipus (Panax bipinnatifidus), Or Panax shudoPanax pseudoginseng) Is known.

Ginseng (Ginsneg Radix) is a perennial herb ginseng ( Panax ginseng ), which contains ginsenoside Rb1, Rc, Rg1, and many other ginsenoside components, and is known to have pharmacological actions such as anticancer, tonic action, hematopoietic action, and blood pressure control action. (Proceedings of Information and Communication, pp. 440-443, 1998).

Rehmania glutinosa is a rhizome belonging to the genus Scrophulariaceae and its components include sitosterol, mannitol, stigmasterol, campesterol, rehmanin, etc. And the antimicrobial effect (Kwang-Sup, Shin-min-gyo, Dae-hae-shi, and Yeonglim, pp. 906-909, 1998).

It is a dried sclerot of polyporus cocos and copepods belonging to Polyporaceae. Its components are pachyman, pachymic acid, tumulosic acid, chitinol, , And the efficacy of diuretic action, antibacterial action, and anti-ulcer action is known (Lee, Seong-min, Shin, Min-gyo, Dae-eung, Jonglim, pp41-43, 1998).

Gyeongokgo, which is currently commercialized, weighs raw materials of raw materials such as raw ginseng, gyeongryeong, raw persimmon juice, and honey, and the raw juice is added to the aged period of the middle part in the order of berry juice, honey, ginseng powder and gyeongryeol. After mixing, the mixture was aged at 105 ± 5 ° C for 72 hours while steam was applied to the double portion. The mixture was allowed to cool to room temperature while stirring continuously, and then sterilized for 24 hours while maintaining 105 ± 5 ° C. Followed by quenching and cooling to room temperature.

However, the excellent moxibustion with excellent drug efficacy has a drawback in that consumers and children who do not like Chinese medicine have a problem of avoiding the general Chinese medicine, especially, pediatric and female patients, . In order to solve such problems, the present invention relates to a process for producing a manganese dioxide powder, which is produced in an acid form such as Rumona (K Pharmaceutical) to remove the bitter taste and increase the texture.

However, none of the above documents teaches or discloses any method of manufacturing a gypsum gypsum powder obtained by using the raw materials of Gyeongokgok as 100% and preserving the efficacy of gyeongokgok while applying the legal process.

Accordingly, the present inventors have developed a process for producing a gypsum gypsum acid powder containing a large amount of the active ingredient of the present invention, thereby eliminating the bitter conventional taste, being convenient to carry and being easy to ingest, The present invention has been accomplished by confirming that it is useful for the development of Kyeongokgosangju which is similar to that of a commercial product and can be easily carried and can be easily and conveniently used for various health benefits.

In order to accomplish the above object, the present invention provides a method for preparing ginseng, ginseng, and ginseng, comprising the steps of: A second step of putting the dry herbal medicine in the first step into an extractor, adding honey and purified water into an extractor and extracting it to obtain an extract; A third step of filtering the extracted liquid of the second step, and then concentrating and vacuum-drying the filtered filtrate to obtain a crude herbal composition; A fourth step of pulverizing the herbal medicine dried product in the third step using a pulverizer to produce a dried extract; A fifth step of adding the excipient to the pulverized dried extract of the fourth step and mixing the mixture with a mixer to obtain a first mixture; A method for producing a second mixture by mixing at least one additive selected from the group consisting of sweeteners, acidifiers, binders, lubricants, disintegrants, colorants, preservatives, sweeteners, flavors, stabilizers or diluents to the first mixture of the fifth step Step 6; A seventh step of adding purified water to the mixture of the sixth step and using a mixer; An eighth step of granulating the combined gypsum gypsum in the seventh step using a granulating machine to obtain granules; Drying the granules to obtain granules in a dry state; And a tenth step of preparing an acid product by grinding the granules of the ninth step with a pulverizer.

In the first step of the above method, the "carrot" is Ginseng (Panax ginseng , Panax quinquefolia , Panax notoginseng , Panax vietnamensis , Panax japonicus , Panax elegatior , Panax wangianus , Ginseng or white gins selected from Panax bipinnatifidus or Panax pseudoginseng; Processed ginseng such as red ginseng and black ginseng or a concentrated liquid thereof.

In the first step of the production process, " rhizome "

In the first step of the above-described manufacturing method, " Bokryeong "

In the first step of the above-described method, the dry herbal medicine has a blending ratio by weight of ginseng: raw persimmon: bokboksul of 0.1 to 10: 1 to 100: 1 to 50 (w / w), preferably 1:10 to 50: 30 (w / w).

In the second step of the method, honey is added in an amount of 1 to 30 parts by weight, preferably 5 to 20 parts by weight to 100 parts by weight of the dry weight of the herbal medicine, v / w), preferably 5 to 20 times volume (v / w).

In the second step of the production method, the extraction is carried out by hot water extraction, reflux extraction, or ultrasonic extraction at a temperature of 10 to 120 ° C for 30 minutes to 1 week, preferably at a temperature of 50 to 110 ° C for 1 hour to More preferably at a temperature of 80 to 100 DEG C for 1 to 72 hours.

In the third step of the production process, the filtration is characterized by filtration with a mesh size of 50 to 400 mesh, preferably 100 to 300 mesh, more preferably 150 to 200 mesh do.

In the third step of the method, the vacuum concentration is carried out at an internal temperature of 50 to 70 DEG C, preferably 55 to 60 DEG C and a vacuum degree of 600 to 800 mmHg, preferably 650 to 700 mmHg, (Brix), preferably 50 to 80 Brix.

In the third step of the method, the vacuum drying is carried out at an internal temperature of 50 ° C to 80 ° C, preferably 60 ° C to 65 ° C and a vacuum degree of 600 to 800 mmHg, preferably 700 to 750 mmHg, .

In the fourth step of the above production method, the pulverization is characterized by pulverizing to 10 to 100 meshes, preferably 15 to 60 meshes, more preferably 20 to 40 meshes do.

In a fifth step of the method, the excipient is characterized by being lactose, lactose, corn starch, potato starch, or glutinous rice starch, or dextrin.

In the fifth step of the above production method, the mixing is performed in a high speed mixer, preferably 1,000 to 2,000 rpm for Chopper rpm, 20 to 80 rpm for Agitator rpm, and 1,700 to 1,800 for Chopper rpm, rpm and Agitator rpm are mixed at a speed of 50 to 60 rpm for 1 minute to 100 minutes, preferably 5 minutes to 30 minutes.

In a sixth step of the method, the additive preferably comprises at least one sweetening ingredient selected from anhydrous crystalline glucose, trehalose, xylitol, aspartame, and stevioside, and a honey powder; Citric acid, malic acid, lemon powder, vitamin C, aronia, tartaric acid; Polyvinylpyrrolidone, hydroxypropylcellulose, microcrystalline cellulose, hydroxypropylmethylcellulose, dextrin, gelatin, methylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, polyvinyl alcohol, pregelatinized starch, , At least one binder component selected from gum arabic; Sodium starch glycolate, crospovidone, cross-linked sodium carboxymethyl cellulose, low-substituted hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, hydroxypropylmethylcellulose, Starch, carboxymethylcellulose calcium, and combinations thereof; At least one lubricant component selected from the group consisting of magnesium stearate, talc, stearic acid, and anhydrous hard silicic acid; At least one colorant component selected from the group consisting of titanium dioxide, iron oxide, magnesium carbonate, calcium sulfate, magnesium oxide, magnesium hydroxide, and aluminum lake; At least one preservative ingredient selected from the group consisting of benzoic acid, benzoic acid, methylparaben, ethylparaben and propylparaben, preferably at least one additive selected from the group consisting of sweeteners and acidifiers.

In the sixth step of the manufacturing method, in addition to the additive component, one or more additives selected from the group consisting of flavorings, stabilizers, and diluents may additionally be added.

In the seventh step of the production method, the association is carried out in a high speed mixer, preferably 1,000 to 2,000 rpm for Chopper rpm, 20 to 80 rpm for Agitator rpm, and 1,600 to 1,700 for Chopper rpm, rpm and agitator rpm are fed at a speed of 45 to 50 rpm for 10 minutes to 120 minutes, preferably 40 minutes to 50 minutes.

In the eighth step of the above manufacturing method, the granulation is characterized by granulating the granulated product in a size of 10 to 200 meshes, preferably 15 to 60 meshes, more preferably 20 to 40 meshes .

In the ninth step of the above production method, the drying is carried out at an intake temperature of 94 to 125 캜, an exhausting temperature of 40 to 85 캜, and a drying temperature of 40 to 85 캜, preferably by a drying method selected from hot air drying, vacuum drying, freeze drying, , It is characterized in that it is dried at an intake temperature of 104 ° C to 105 ° C and an exhaust temperature of 60 ° C to 65 ° C.

In the tenth step of the above production method, the acid agent is characterized by having a particle diameter of 355 mu m to 37 mu m, and preferably 150 mu m to 74 mu m.

Unlike granules which are difficult to ingest without water, Gyeongokgosangju obtained from the above can easily be consumed without water, like a commercial product (Lemon); In order to minimize the bitter taste of Kyeongok-gok, it is recommended to add acidic agent and sweetener to the existing Kyeongokgyo extract to enhance the taste of the product by enhancing the taste of the product. In addition, It is a new concept of gyeongokgosangju which has the advantages of having the same effective ingredient content as existing gyeongokgyo by manufacturing the acid form of gyeongokgok based on the Gyeongokgokgol prescription based on the Dongbokgoppyeon solution. We confirmed the efficacy.

Gyeongokgogo, which is listed in Donguibogam, is a process of legislative process during the manufacturing process, whereby catalpol content of ginseng, ginsenoside Rg3 content of red ginseng, and pachymic acid content of gyeongryong are changed The gyeongokgyo acid product of the present invention was found to have almost the same or similar contents of catalopol content of ginseng, ginsenoside Rg3 content of red ginseng, and pachymic acid content of gyeonghyeol, I confirmed that it is a powder.

Accordingly, the present invention provides a mushroom powder product containing a large amount of the active ingredient prepared by the above production method.

Hereinafter, the specific configuration of the present invention will be described in detail with reference to examples. However, the scope of the present invention is not limited to the description of these embodiments.

The method of producing a mushroom powder containing a large amount of the active ingredient of the present invention is advantageous in that it removes a bitter taste, is convenient to carry, is easy to ingest, and maintains the pharmacological effect of the existing mushroom. (REMONA), which makes it easy to drink without water; In order to minimize the bitter taste of Kyeongok Ok, it is useful for the development of simple food, nutritious food, etc. with various advantages such as adding acidic agents and sweeteners to the existing Kyeongokgyo extract to enhance flavor and taste.

Fig. 1 is a photograph of the final mushroom powder prepared in Example; Fig.
FIG. 2 is a photograph of a mildew paste prepared in Example; FIG.
FIG. 3 shows the results of comparative analysis of the production of Rg3 (HPLC data) of red ginseng contained in ginseng (pre-treatment), which is a raw material of Gyeongokgok, and red ginseng contained in Wonkwang Pharmaceutical Co., Ltd.
FIG. 4 shows the results of comparative analysis (HPLC data) for the production of Rg3 in red ginseng contained in ginseng (pre-treatment) raw material of Kyunghee Kogyo and gyeongokgogosan (post-treatment);
FIG. 5 is a graph showing the results of comparative analysis of catalpol reduction (HPLC data) of sulfur contained in catalpol contained in the raw material of gyeongokgyo (pre-treatment) and in the case of bohwa gyeongokgogo (treated) of Wonkwang Pharmaceutical Co., Ltd.;
FIG. 6 shows the results of comparative analysis (HPLC data) of reduction of catalpol in guinea pig contained in catalpol and gypsum ginkgo acid (after legal treatment) contained in ginseng (raw)
FIG. 7 shows the results of comparative analysis (HPLC data) of pachymic acid contained in pachymic acid and Wonkwang Pharmaceutical Co., Ltd.
8 is a comparative analysis (HPLC data) of the reduction of pachymic acid contained in pachymic acid and gyeonghokgosanju (after the legal treatment) contained in the gyeongokgyo raw material (pre-treatment).

Hereinafter, the present invention will be described in detail with reference to the following examples and experimental examples.

However, the following Examples and Experimental Examples are merely illustrative of the present invention, and the contents of the present invention are not limited by the following Examples, Reference Examples and Experimental Examples.

Reference example  1. Wonkwang Pharmaceutical Co., Ltd. Kyunghee University  Produce

The ginseng raw material, ginseng, bamboo juice, and honey were weighed and placed in the middle aged period in the order of bamboo juice juice, honey, ginseng powder, and gyeongryeong powder, followed by stirring for 1 hour.

After mixing, the mixture was aged at 105 ± 5 ° C for 72 hours while steam was applied to the double portion. The mixture was allowed to cool to room temperature while stirring continuously, and then sterilized for 24 hours while maintaining 105 ± 5 ° C. Quenched and cooled to room temperature.

Example  One. Kyunghee University Sanje  Produce

The ginseng (900 g), raw persimmon (9,600 g) and Baekbokryeong (1,800 g) were thoroughly washed with water according to the prescription standard described in Dong-bo-gyogam, and the water was removed and put into an extractor. Further, honey (1,300 g) and purified water (150 liters) (HY2 Han Yeon ENC) and extracted at 90 to 95 DEG C for 36 hours.

After extraction, it was filtered with a 180 mesh filter net Vacuum drying ((LVO-2050, Laptech Co., Ltd.) vacuum degree of 700-750 mmHg, internal temperature of 55-60 ° C, vacuum degree of 650-700 mmHg) using a vacuum concentrator (HY2 Han Ye ENC) 60 占 폚 to 65 占 폚) and then pulverized using a grinder (Anpung Machinery Co.) at 100 mesh.

(3,536 g) and the excipient (lactose or lactose) (1,415 g) were mixed for 10 minutes using a High Speed Mixer (Chopper rpm 1,700-1,800, Agitator rpm 50-60 by HLSG-120P Ilshin Co.) Respectively.

1,000 ml of purified water was added to the mixture, and a high speed mixer ((HLSG-120P Ilshin Sha) Chopper rpm 1,600 ~ 5,000) was added to the mixture, and the resulting mixture was further mixed with a sweetener (495 g of a honey powder) and an acidifier (15 mg of citric acid and 163 g of lemon powder) 1,700, agitator rpm 45-50) for 45 to 50 minutes.

The Joint-Venture Joint-Stock Company was granulated using a granulator (Stainless 30 mesh mesh instead of DS-2). The granules were dried in a hot-air dryer (DM-136LU Duritek FA) at an intake temperature of 104 ° C to 105 ° C and an exhaust temperature of 60 ° C to 65 ° C).

The dried granules were ground with a crusher (Anpung Machinery Co.) to obtain 4,350 g of Kyoikoku Kosan (90-100 m). (See Figs. 1 and 2)

Experimental Example  One. Kyunghee University  Comparison of composition analysis of extract

In order to confirm whether or not the active ingredient of kiyokokgojo jelly jelly jelly in the above-mentioned example was transferred, extracts of ginseng, bamboo shoots, and raw persimmon were added to an extractor for extraction at 90 to 95 ° C for 36 hours, and after concentrating for 24 hours, a concentrate was obtained and dried. The extracts were prepared by mixing the excipients with dry excipients and using a squid mixer. The samples were subjected to the legal procedures such as Rg3 production of red ginseng, reduction of catalpol of ginseng and reduction of pachymic acid in the ginseng. HPLC was carried out under the same conditions.

1-1. HPLC  Condition

1-1-1. Zygotic component HPLC  Condition

The HPLC conditions were as follows: ACE (250 × 4.6 mm, ACE) column was used, flow rate was 1.0 mL / min, column temperature was 40 ° C. and sample injection amount was 20 μL. The experimental conditions are shown in Table 1 below.

LC-Waters e2695 (Waters U.S.A) was used for analytical HPLC, and Waters 2489 (Waters U.S.A) was used as a detector. All of the analytical reagents such as AcCN and MeOH were measured using HPLC reagents, and all of the extraction and fractionation solvents used were special grade reagents.

HPLC condition for analysiss Instrument LC LC-Waters e2695 (Waters U.S.A) Detector Waters 2489 (Waters U.S.A) Column ACE column (250 x 4.6 mm, discoverysciences) Operating condition UV Absorbance 206 nm Column temp. 40 ℃ Injection Vol. 20 μl Mobile phase 1% Acetonitrile

1-1-2. Red ginseng ingredient HPLC  Condition

HPLC conditions were as follows: Apollo (250 × 4.6 mm, discoverysciences) was used, the flow rate was 1.0 mL / min, the column temperature was 40 ° C., and the sample injection amount was 20 μL. The experimental conditions are shown in Table 2 below.

LC-Waters e2695 (Waters U.S.A) was used for analytical HPLC, and Waters 2489 (Waters U.S.A) was used as a detector. All of the analytical reagents such as AcCN and MeOH were measured using HPLC reagents, and all of the extraction and fractionation solvents used were special grade reagents.

HPLC condition for analysiss Instrument LC LC-Waters e2695 (Waters U.S.A) Detector Waters 2489 (Waters U.S.A) Column ACE column (250 x 4.6 mm, discoverysciences) Operating condition UV Absorbance 203 nm Column temp. 40 ℃ Injection Vol. 20 μl Mobile phase A Water Mobile phase B Acetonitrile Gradient profile Time (min) % A % B Flow (mL / min) 0 80 20 1.0 5 80 20 1.0 20 66 34 1.0 25 63 37 1.0 30 55 45 1.0 35 50 50 1.0 60 15 85 1.0 62 15 85 1.0 65 80 20 1.0 70 80 20 1.0

1-1-3. HPLC

The HPLC conditions were as follows: ACE (250 × 4.6 mm, ACE) was used for the HPLC. The flow rate was 1.0 mL / min, the column temperature was 40 ° C., and the sample injection amount was 20 μL. The experimental conditions are shown in Table 3 below.

LC-Waters e2695 (Waters USA) was used for analytical HPLC, and Waters 2489 (Waters USA) was used as a detector. All analytical reagents such as AcCN, MeOH and EtOH were measured using HPLC reagents, and all reagents for extraction and fractionation were all of the special reagents.

HPLC condition for analysiss Instrument LC LC-Waters e2695 (Waters U.S.A) Detector Waters 2489 (Waters U.S.A) Column ACE (250 x 4.6 mm, ACE) Operating condition UV Absorbance 210 nm Column temp. 40 ℃ Injection Vol. 20 μl Mobile phase 88% Acetonitrile

1-2. Standard solution and Of the test solution  Produce

1-2-1. Comparison

For the comparative analysis of the catalpol content of guinea pigs and the catalpol content of gypsum gypsum powder in Woong Kwang Pharmaceutical Co., the standard solution was 100 μg / mL of catalopol standard (wako) After dissolving in MeOH and filtration with 0.45 μM membrane filter (Whatman Inc., Florham Park, NJ), 2 g of the sample is dissolved in 50 mL of 30% MeOH and sonicated for 2 hours. After filtration and centrifugation (2,000 rpm, 10 min) (Vision Science), the supernatant was analyzed by filtration through a 0.45 μM membrane filter (Whatman Inc., Florham Park, NJ).

1-2-2. Comparison of red ginseng ingredients

For the comparative analysis of the ginsenoside Rg3 content of red ginseng and the Rg3 content of ginseng ginseng ginseng root in Woong Kwang Pharmaceutical Co., the standard solution was 100 g / mL, and then filtered through a 0.45 μM membrane filter (Whatman Inc., Florham Park, NJ). Take 2 g of the sample and dissolve in 50 mL of water for 1 hour. And analyzed by filtration with 0.45 μM membrane filter.

1-2-3. Comparison of ingredients

For the comparative analysis of the content of pachymic acid in the Bokwha japonica and the content of pachymic acid in the gyeongokgok spa, the standard solution was pachymic acid standard (chengdu) The resulting solution was filtered through a 0.45 μM membrane filter (Whatman Inc., Florham Park, NJ), and the filtrate was subjected to reflux extraction for 3 hours with 100 ml of EtOH after taking 15 g of the obtained sample. mu] M membrane filter.

1-3. HPLC Component analysis using

As a result of this experiment, the contents of catalpol and the contents of catalopol of zeolite were found to be 0.23 mg / g and 0.38 mg / g, respectively, in Bohwa kyokoko Co., Ltd. , 6); The ginsenoside Rg3 content of red ginseng and the red ginseng content of ginseng herb ginseng were 0.06 mg / g and 0.17 mg / g, respectively, in Woong Kagaku Co., Ltd. (Figs. The content of pachymic acid in the bamboo shoots contained in Wonkwang Pharmaceutical Co., Ltd. and the content of pachymic acid in the bamboo shoots of Gyeongokgok Sanju were 0.09 mg / g and 0.02 mg / g, respectively (Figs. ). As a result, it was confirmed that the Kyoeokgosan powder of the present invention contained a large amount of kiyokokogo component and was similar to the component of Woonghwa kyokoko.

Experimental Example 2. Simplified Clinical Experiment

A comparative experiment was conducted to examine the taste, flavor, ease of use, and the like of 100 applicants of 10 to 60 year old male and female applicants in Kyeongokgosangju and Kyeongokgyo in Jeonbuk Iksan. Point, good 3 point, average 2 point, bad 1 point, very bad 0 point)

As a result of the above-mentioned experiment, as shown in the following Table 1, the gypsum gypsum gypsum of the present invention has 15 points, whereas the existing gypsum gypsum gypsum has 8 points, which shows that the gypsum gypsum gypsum of the present invention is superior in terms of preference.

product Rating index flavor incense convenience preference Total point Kyeongokgyo powder 4 3 4 4 15 Wonkwanghwa Hwaokgyo 2 2 2 2 8

Claims (13)

Panax ginseng ( Panax ginseng ), Panax quinquefolia , Panax notoginseng , Panax vietnamensis , Panax japonicus , Panax elegatior , Panax wanianus a blending ratio of 1 to 50 (w / w): Panax wangianus), Panax non pinna typhus (Panax bipinnatifidus), or Panax pseudo ginseng (Panax 0.1 to 10 selected fresh ginseng or white ginseng, saengjihwang and baekbokryeong from pseudoginseng): 1 to 100 A first step of mixing, washing, and drying to prepare a dried herbal medicine; The dried herbal medicine in the first step is added to the extractor and the honey and the purified water are added in an amount of 1 to 30 parts by weight to 100 parts by weight of the dried herbal medicine, and the purified water is mixed with 1 to 30 times volume (v / w) And a second step of extracting the extract by hot water extraction at a temperature of 80 to 100 DEG C for 1 to 72 hours; The filtrate of the second step is filtered through 50 to 400 mesh and the filtered filtrate is subjected to an internal temperature of 50 to 70 DEG C and a degree of vacuum of 600 to 800 mmHg to be concentrated in vacuo at 10 to 100 Brix Vacuum drying at an internal temperature of 50 ° C to 80 ° C and a vacuum degree of 600 to 800 mmHg to obtain a crude herbal composition; A fourth step of pulverizing the herbal medicine dried product in the third step using a pulverizer to produce a dried extract; The excipient selected from lactose or granulated lactose is added to the pulverized dried extract of the fourth step, the chopper rpm is 1,000 to 2,000 rpm, the agitator rpm is 1 to 20 minutes, Mixing the mixture with a high-speed mixer for 100 minutes to obtain a first mixture; A sweetener selected from anhydrous crystalline glucose or powdered honey in the first mixture of step 5; Citric acid, malic acid, lemon powder, vitamin C, aronia, tartaric acid; Polyvinylpyrrolidone, hydroxypropylcellulose, microcrystalline cellulose, hydroxypropylmethylcellulose, dextrin, gelatin, methylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, polyvinyl alcohol, pregelatinized starch, , At least one binder component selected from gum arabic; Sodium starch glycolate, crospovidone, cross-linked sodium carboxymethyl cellulose, low-substituted hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, Starch, carboxymethylcellulose calcium, and combinations thereof; At least one lubricant component selected from the group consisting of magnesium stearate, talc, stearic acid, and anhydrous hard silicic acid; At least one colorant component selected from the group consisting of titanium dioxide, iron oxide, magnesium carbonate, calcium sulfate, magnesium oxide, magnesium hydroxide, and aluminum lake; A sixth step of preparing a second mixture by mixing at least one additive selected from the group consisting of benzoic acid, methylparaben, ethylparaben, propylparaben, at least one preservative ingredient selected from the group consisting of sweeteners, flavors, stabilizers, ; The purified water is added to the mixture of the sixth step and the chopper rpm is 1,000 to 2,000 rpm and the agitator rpm is a high speed mixer for 10 to 120 minutes at a speed of 20 to 80 rpm, A seventh step of associating using the first step; An eighth step of granulating the Kyoikoku Kyoons combined in the seventh step with 20 to 40 mesh using a granulator to obtain granules; Drying the granules at an inlet temperature of 94 ° C to 125 ° C and an outlet temperature of 40 ° C to 85 ° C by hot air drying to obtain dried granules; And a tenth step of grinding the granules of the ninth step with a pulverizer to prepare powders having a size ranging from 150 mu m to 74 mu m. delete delete delete delete delete delete delete delete delete delete delete delete

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