CN1058162C - Pearl oral liquor capable of clearing away heart-fire - Google Patents
Pearl oral liquor capable of clearing away heart-fire Download PDFInfo
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- CN1058162C CN1058162C CN95103108A CN95103108A CN1058162C CN 1058162 C CN1058162 C CN 1058162C CN 95103108 A CN95103108 A CN 95103108A CN 95103108 A CN95103108 A CN 95103108A CN 1058162 C CN1058162 C CN 1058162C
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- oral liquor
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- sweating
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Abstract
The present invention discloses a pearl oral liquor capable of clearing away heart fire, and the pearl oral liquor can be used for treating sweat syndromes caused by endogenous heat due to yin deficiency of children. The pearl oral liquor is prepared from cape jasmine fruit, lotus plumule, nacre, oyster shell, cicada slough, fermented soybean, mulberry leaf, dried longan pulp, tuckahoe, lotus seed, glycyrrhiza, sucrose, sodium benzoate and water, and has the efficacy for clearing the heart, eliminating vexation, constraining yin and arresting sweating. Results of clinical tests show that the pearl oral liquor has good therapeutic effect on sweat syndromes caused by endogenous heat due to yin deficiency of children, and can be used for treating syndromes of night sweating, spontaneous sweating, vexation, reduced sleep, xerostomia, heat in the heart of the palms and soles, etc. of children.
Description
What the present invention relates to is to be used for the treatment of children's's interior-heat caused by deficiency of YIN, fidgetyly to sleep the Chinese medicine preparation of spontaneous perspiration, night sweat less.
Motherland's medical science is thought: children's's antiperspirant disease has the branch of spontaneous perspiration, night sweat, the middle diaphoresis of sleeping, and the perspiration stopped person is called " night sweat " when waking up, and is regardless of awake and sleeps, and sweating person claims " spontaneous perspiration " without reason.Night sweat mostly is the deficiency of YIN, and spontaneous perspiration mostly is yang deficiency.Therefore spontaneous perspiration, night sweat are all because of due to the void.Because interior-heat caused by deficiency of YIN, make children's's Sleep hyperhidrosis, fidgetyly sleep less, xerostomia lack of appetite, emaciated physique.To these diseases, doctor trained in Western medicine thinks due to the calcium deficiency that treatment is many to be aided with vitamin A, D to replenish the calcium, and to help the absorption of calcium, this Therapeutic Method produces little effect clinically.The traditional Chinese medical science all is to take the relieving restlessness that clears away heart-fire, the method for astringing YIN to stop sweating when this type of disease of treatment.Be to select the medicine of heat clearing away YIN nourishing, the relieving restlessness of calming the nerves to face the disease plus-minus clinically with treatment.Find no the patent medicine easy to use of the above-mentioned disease of treatment clinically, this is a kind of really sorry.
Purpose of the present invention is screened some effective medicines exactly, becomes to be fit to child administration by suitable prepared, can treat effectively children's's interior-heat caused by deficiency of YIN, less sleep fidgety, the pharmaceutical preparation of symptoms such as Sleep hyperhidrosis or spontaneous perspiration.
For achieving the above object, the measure that the present invention takes is: pearl oral liquor capable of clearing away heart-fire, go out Fructus Gardeniae, Plumula Nelumbinis, Concha Margaritifera, Concha Ostreae, Periostracum Cicadae, Semen Sojae Preparatum, Folium Mori, Arillus Longan, Poria, Semen Nelumbinis, Radix Glycyrrhizae, sugar, sodium benzoate and water are formed, when the present invention is 1000 milliliters, contain Fructus Gardeniae 50～100g, Plumula Nelumbinis 10～50g, Concha Margaritifera 80～160g, Concha Ostreae 80～160g, Periostracum Cicadae 30～90g, Semen Sojae Preparatum 60～100g, Folium Mori 120～180g, Arillus Longan 20～80g, Poria 80～120g, Semen Nelumbinis 80～160g, Radix Glycyrrhizae 20～60g, sugar 180g, sodium benzoate 3g, surplus is a water.
Employed active ingredient is kind of being recorded of Chinese Pharmacopoeia nineteen ninety version among the present invention, and nonactive composition sodium benzoate, steaming sugar are two kinds of recording of Chinese Pharmacopoeia nineteen ninety version.Through pharmacodynamics test and clinical verification, proof the present invention has the relieving restlessness of clearing away heart-fire, the effect of astringing YIN to stop sweating, clinical symptom such as the night sweat that the children's's antiperspirant disease due to the interior-heat caused by deficiency of YIN is occurred, spontaneous perspiration, fidgety poor, xerostomia polydipsia feverish sensation in the palms and soles of sleeping has significant improvement effect, and aggregate efficiency reaches 96.7%.Through Guangxi Chinese medicine institute pharmacodynamics test, the result is as follows:
A, tranquilizing effect
A, to the influence of normal white mice spontaneous activity.Select 40 of healthy mices, divide four groups at random, establish matched group, positive controls, two dosage of administration component size, equal gastric infusions, walking about with white mice in 2 minutes, upwards to praise number of times be index for time and two forelegs.The result shows that gastric infusion 30 gram crude drug/kg of the present invention and positive controls can obviously suppress the white mice spontaneous activity.
B, to the influence of pentobarbital sodium mouse sleep time.Select 40 of healthy mices, divide four groups at random, if matched group, positive controls, two dosage of administration component, gastric infusion is after 60 minutes, lumbar injection threshold dose pentobarbital sodium 50mg/kg, with righting reflex loss to recovery time be sleep time, with matched group relatively, the result shows: gastric infusion 30g crude drug/kg of the present invention, 15g crude drug/kg and positive controls, all can obviously prolong pentobarbital sodium length of one's sleep, show that the present invention has the effect of collaborative penta crust through appropriate sodium.
C, to the influence of HD under the pentobarbital sodium valves.Select 40 of healthy mices, divide four groups at random, gastric infusion is after 1 hour, by HD 30mg/kg under the lumbar injection pentobarbital sodium valves, observes in 15 minutes the animal righting reflex loss and reaches and be sleeping index more than 1 minute.The result shows: gastric infusion 30g crude drug/kg of the present invention, 15g crude drug/kg and all can increase the sleeping number of animals of HD under the pentobarbital sodium valves to positive controls.
More than experimental results show that: the present invention has tranquilizing effect.
B, anti-frightened fault effect
With pentetrazole for causing frightened agent, observing the present invention causes convulsions amount (CD50) to the mice half influence.Select 100 of mices for use, divide two to organize greatly at random, every big group is further divided into five groups, two big groups gavage 20g/kg of the present invention and normal saline 0.2ml/10g body weight respectively, administration respectively organizes the pentetrazole of lumbar injection various dose respectively after 60 minutes, be index with the mice against seizure overturning, the half that calculates matched group and administration group by the Guan Shi method respectively causes convulsions amount (CD50).The result shows: gastric infusion 20g/kg of the present invention, can improve mice pentetrazole CD50 ratio 19.3%, and prompting this product has certain anticonvulsant action.
C, sweating test.Utilize iodine and starch to meet the mechanism that perspiration produces purple color reaction, observe the influence of the present invention rat foot sole of the foot sweat secretion.Select 32 of healthy white rats, divide four groups at random, establish positive controls, matched group, administration group 30g crude drug/kg and administration group 15g crude drug/kg, behind the gastric infusion, observe rat foot sole of the foot portion antiperspirant respectively and point out between now, color and quantity were observed 30 minutes continuously.The result shows: rat gastric infusion 30g crude drug/kg of the present invention, and 15g crude drug/kg, antiperspirant point all are less than matched group, prove that the present invention can reduce the secretion of perspiration under doses, and prompting has anti-hidropoiesis.
The art of facing through the People's Hospital, Guangxi district and Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi verifies that the result is as follows:
The tcm diagnosis standard: sweating syndrome is meant a kind of disease of undesired perspiration.Promptly under rest state, or nothing is so whole body or local excessive sweating, very then dripping sweat.Sweating disease in children has the branch of spontaneous perspiration, night sweat, all belongs to " void ", and assertive evidence refers to the sweating that causes because of empty.It is the object of observation that the syndrome of endogenous heat due to yin deficiency person is selected in clinical verification, and its pattern of syndrome standard is: based on night sweat, or companion's spontaneous perspiration, and emaciated physique, god withers depressed, vexedly sleeps less, the back hyperhidrosis of sleeping, or accompany low grade fever, xerostomia, brothers' Heartburn, tongue is few or see exfoliative fur, thready and rapid pulse or through number.
Observe treatment and organize 120 examples, use the present invention, oral, 1-2 year 5ml, a twice-daily; 3-4 year 5ml, three times on the one; 5-6 year 10ml, a twice-daily serve on 7 days.Clinical results shows that the present invention has therapeutical effect preferably to the sweating syndrome infant of syndrome of endogenous heat due to yin deficiency.Treatment back infant night sweat or spontaneous perspiration, fidgetyly sleep less, cards such as xerostomia, feverish sensation in the palms and soles all have clear improvement (P＜0.01), announcement the present invention has the effect of the relieving restlessness of clearing away heart-fire, astringing YIN to stop sweating.Safe and reliable, no obvious adverse reaction and toxic and side effects.
Describe the present invention in detail below in conjunction with embodiment.
Fructus Gardeniae 50g Plumula Nelumbinis 10g Folium Mori 120g Arillus Longan 20g
Concha Margaritifera 80g Concha Ostreae 80g Poria 80g Semen Nelumbinis 80g
Periostracum Cicadae 30g Semen Sojae Preparatum 50g Radix Glycyrrhizae 20g sucrose 180g
Sodium benzoate 3g water is an amount of
By following prepared, get Six-element medicine pulverize separately such as Fructus Gardeniae, Concha Margaritifera, Concha Ostreae, Semen Nelumbinis, Radix Glycyrrhizae, Poria and become coarse powder, add five kinds of Chinese medicine mixings such as Plumula Nelumbinis, Semen Sojae Preparatum, Arillus Longan, Folium Mori, Periostracum Cicadae, use water boiling and extraction, extracting liquid filtering, it is 1.02～1.15 (60～70 ℃) that filtrate is concentrated into relative density, adding ethanol is 40～80% to carry out precipitate with ethanol to containing the alcohol amount, filter, filtrate is concentrated into relative density 1.05～1.26 (65～70 ℃), add suitable quantity of water and sucrose, sodium benzoate, accent total amount to 1000ml, filter packing promptly.
Embodiment 2
Fructus Gardeniae 75g Plumula Nelumbinis 30g
Concha Margaritifera 120g Concha Ostreae 120g
Periostracum Cicadae 60g Semen Sojae Preparatum 75g
Folium Mori 150g Arillus Longan 60g
Poria 100g Semen Nelumbinis 120g
Radix Glycyrrhizae 40g sucrose 180g
Sodium benzoate 3g water is an amount of
Press the processing step preparation of embodiment 1.
Embodiment 3
Fructus Gardeniae 100g Plumula Nelumbinis 50g
Concha Margaritifera 160g Concha Ostreae 160g
Periostracum Cicadae 90g Semen Sojae Preparatum 100g
Folium Mori 180g Arillus Longan 80g
Poria 120g Semen Nelumbinis 160g
Radix Glycyrrhizae 60g sucrose 180g
Sodium benzoate 3g water is an amount of
Press the processing step preparation of embodiment 1
Claims (1)
1. pearl oral liquor capable of clearing away heart-fire, it is characterized in that when described oral liquid is 1000 milliliters it is that the raw material of water is made by Fructus Gardeniae 50-100g, Plumula Nelumbinis 10-50g, Concha Margaritifera 80-160g, Concha Ostreae 80-160g, Periostracum Cicadae 30-90g Semen Sojae Preparatum 50-100g, Arillus Longan 20-80g, Folium Mori 120-180g, Poria 80-120g, Semen Nelumbinis 80-160g, Radix Glycyrrhizae 20-60g, sucrose 180g, sodium benzoate 3g, surplus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95103108A CN1058162C (en) | 1995-03-17 | 1995-03-17 | Pearl oral liquor capable of clearing away heart-fire |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95103108A CN1058162C (en) | 1995-03-17 | 1995-03-17 | Pearl oral liquor capable of clearing away heart-fire |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1131550A CN1131550A (en) | 1996-09-25 |
| CN1058162C true CN1058162C (en) | 2000-11-08 |
Family
ID=5074595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95103108A Expired - Fee Related CN1058162C (en) | 1995-03-17 | 1995-03-17 | Pearl oral liquor capable of clearing away heart-fire |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1058162C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101278981B (en) * | 2007-04-02 | 2011-09-07 | 上海市儿童医院 | Medicament for treating upper respiratory tract infection in children and preparation method thereof |
| CN103478842B (en) * | 2013-10-08 | 2015-10-14 | 重庆百农网投资有限公司 | Micro-bitter type beverage and preparation method thereof |
-
1995
- 1995-03-17 CN CN95103108A patent/CN1058162C/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 《陕西中医》1991年第12卷第12期 1991.12.1 杨福盛，茵陈牡蛎汤治疗小儿盗汗140例 * |
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| Publication number | Publication date |
|---|---|
| CN1131550A (en) | 1996-09-25 |
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