CN102526243A - Traditional Chinese medicine combination for clearing heat and tonifying qi and preparation method thereof - Google Patents
Traditional Chinese medicine combination for clearing heat and tonifying qi and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine combination for clearing heat and tonifying qi and a preparation method thereof, which belong to the field of traditional Chinese medicine modernization. The traditional Chinese medicine combination for clearing heat and tonifying qi is characterized in that the active constitutions are composed of raw materials by parts of weight: 103 parts of coptis chinensis, 154 parts of astragalus mongholicus and 618 parts of honeysuckle. The traditional Chinese medicine combination has the advantages of being stable and controllable in quality, remarkably high in curative effect compared with existing drugs sold in markets, and obvious in economic and social benefits.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and method for preparing of heat clearing away QI invigorating, belong to modern Chinese traditional medicine field.
Background technology
Diabetes (Diabetes) are divided IDDM and type 2 diabetes mellitus.In diabetics, the shared ratio of type 2 diabetes mellitus is about 95%.Wherein the IDDM pilosity is born in teenager, because of insulin secretion lacks, relies on exogenous insulin and replenishes to earn a bare living.During type 2 diabetes mellitus is more common in, the old people, its secretion of insulin amount is not low, even also higher, it is responsive inadequately to insulin that clinical manifestation is a body, promptly insulin resistant (Insulin Resistance, IR).The clinical observation insulin resistant is prevalent in the type 2 diabetes mellitus, up to about 90%.
Diabetes can cause infection, heart change, cerebrovascular disease, renal failure, lose the sight of both eyes, lower limb gangrene etc. and become deadly major cause of morbidity.The diabetes height oozes the serious acute complication that syndrome is diabetes; Starting stage can show as polyuria, polydipsia, fatigue and weakness, bradykinesia etc.; Along with the increase state of an illness of body fluid loss sharply develops; Drowsiness, disorientation appears, epileptic is twitched, the symptom of similar apoplexy such as hemiplegia, even stupor.
Just put down in writing " diabetes " this name of disease in China's medical book Plain Questions of Huangdi's Internal Classic and Miraculous Pivot the earliest.The piece of writing of quenching one's thirst of Han dynasty well-known doctor's Zhang Zhongjing " Medical Treasures of the Golden Chamber " is also on the books to " more than three " symptom.
JINQI JIANGTANG PIAN is present commercially available a kind of Chinese medicine of treating diabetes, and its heat clearing away QI invigorating is used for heat syndrome in the diabetes deficiency of vital energy, and disease is seen thirst and liking drink, is prone to hungry polyphagia, shortness of breath and fatigue.Gently, moderate type non-insulin-dependent diabetes mellitus is seen above-mentioned patient.Pharmacological evaluation shows that JINQI JIANGTANG PIAN has the carbohydrate metabolism of improvement, but blood sugar lowering.Improve carbohydrate tolerance, promote hepatic glycogen synthetic, alleviate the symptom more than three that hyperglycemia causes.To the insulin resistance of laboratory animal, the effect of having clear improvement, enhancing body is to sensitivity endogenous, the exogenous insulin effect.Can correct abnormalities of sugar/lipid metabolism, reduce serum triglycerides and alleviate fatty liver.In addition, these article have the enhancing human body immunity function of (comprising humoral immunization and cellular immunization).
The present invention has improved technology on the basis of existing technology, in the hope of further improving curative effect of medication.
Summary of the invention
First technical problem that the present invention will solve provides a kind of Chinese medicine composition of heat clearing away QI invigorating.
Another technical problem that the present invention will solve provides manufacturing method for above mentioned medicine.
For realizing above-mentioned purpose, the present invention adopts following technical scheme:
A kind of Chinese medicine composition of heat clearing away QI invigorating, its active component is processed by the raw material of following parts by weight: 618 parts of 154 portions of Flos Loniceraes of 103 parts of Radixs Astragali of Rhizoma Coptidis.
Said active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; Rhizoma Coptidis, the Radix Astragali use 6-10 doubly to measure concentration of volume percent to be the ethanol extraction of 50%-90% 2-3 time, and each 1-3 hour, merge extractive liquid, was concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 8-14 times of water gaging warm macerating 2-3 time under 50-90 ℃ of condition, and each 0.5-3 hour, merge warm macerating liquid, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I.Dry thing I is active component of the present invention.
Said active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; Rhizoma Coptidis, the Radix Astragali use 8-10 doubly to measure concentration of volume percent to be the ethanol extraction of 60%-80% 2-3 time, and each 2-3 hour, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 10-12 times of water gaging warm macerating 2-3 time under 50-90 ℃ of condition, and each 1-2 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I.
Said active component adopts following method to prepare: it is 80% ethanol extraction 2 times that Rhizoma Coptidis, the Radix Astragali are used 8 times of amount concentration of volume percent, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 10 times of water gagings warm macerating 2 times under 50-90 ℃ of condition, and each 1 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I.
Said pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
Said pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
The dosage form of said Chinese medicine composition is a peroral dosage form, includes but not limited to pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
A kind of method for preparing of Chinese medicine composition of heat clearing away QI invigorating takes by weighing 618 parts of 154 portions of Flos Loniceraes of 103 parts of Radixs Astragali of Rhizoma Coptidis; Rhizoma Coptidis, the Radix Astragali use 6-10 doubly to measure concentration of volume percent to be the ethanol extraction of 50%-90% 2-3 time, and each 1-3 hour, merge extractive liquid, was concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 8-14 times of water gaging warm macerating 2-3 time under 50-90 ℃ of condition, and each 0.5-3 hour, merge warm macerating liquid, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I.Dry thing I is active component of the present invention.
Preferred manufacturing procedure is: take by weighing each raw material by proportioning raw materials; Rhizoma Coptidis, the Radix Astragali use 8-10 doubly to measure concentration of volume percent to be the ethanol extraction of 60%-80% 2-3 time, and each 2-3 hour, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 10-12 times of water gaging warm macerating 2-3 time under 50-90 ℃ of condition, and each 1-2 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I.
Most preferred method for preparing is: it is 80% ethanol extraction 2 times that Rhizoma Coptidis, the Radix Astragali are used 8 times of amount concentration of volume percent, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 10 times of water gagings warm macerating 2 times under 50-90 ℃ of condition, and each 1 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I.
Chinese medicine composition that technical scheme of the present invention is related and preparation thereof all have good heat clearing away QI invigorating, improve carbohydrate metabolism, but blood sugar lowering.Improve carbohydrate tolerance, promote hepatic glycogen synthetic, alleviate the symptom more than three that hyperglycemia causes.Through zoopery, we find that unexpectedly the pharmaceutical composition of prepared of the present invention is compared with former dosage form, have excellent blood sugar reducing function.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property and the Pharmacological action study result of each flavour of a drug ingredient, research has obtained the new method for preparing of reasonable, stable active component.Adopt technical scheme of the present invention, prepared stable and controllable for quality, curative effect and compared with existing commercially available dosage form and significantly improve, have remarkable economical and social benefit.
Below specify technical scheme of the present invention through embodiment, do not limit practical range of the present invention with this.
The specific embodiment
Embodiment 1: the preparation Chinese medicine extract
One. prescription: Rhizoma Coptidis 103g Radix Astragali 154g Flos Lonicerae 618g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; It is 80% ethanol extraction 2 times that Rhizoma Coptidis, the Radix Astragali are used 8 times of amount concentration of volume percent, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 10 times of water gagings warm macerating 2 times under 60 ℃ of conditions, and each 1 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I and is active component 175 grams of the present invention.
Embodiment 2: the preparation Chinese medicine extract
One. prescription: Rhizoma Coptidis 1030g Radix Astragali 1540g Flos Lonicerae 6180g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; It is 60% ethanol extraction 2 times that Rhizoma Coptidis, the Radix Astragali are used concentration of volume percent; Measure 60% ethanol extractions 3 hours with 8 times for the first time, measured 60% ethanol extractions 2 hours, merge extractive liquid, with 6 times for the second time; Be concentrated into that relative density is 1.08 under the 50-60 ℃ of condition, obtain concentrated solution A; Flos Lonicerae is with 12 times of water gagings warm macerating 2 times under 80 ℃ of conditions, and each 1 hour, merge warm macerating liquid, be concentrated into that relative density is 1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I and is active component 1150 grams of the present invention.
Embodiment 3: the preparation Chinese medicine extract
One. prescription: Rhizoma Coptidis 103g Radix Astragali 154g Flos Lonicerae 618g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; It is 50% ethanol extraction 3 times that Rhizoma Coptidis, the Radix Astragali are used 6 times of amount concentration of volume percent, and each 1 hour, merge extractive liquid, was concentrated into that relative density is 1.03 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 8 times of water gagings warm macerating 3 times under 50 ℃ of conditions, and each 3 hours, merge warm macerating liquid, be concentrated into that relative density is 1.03 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I and is active component 183 grams of the present invention.
Embodiment 4: the preparation Chinese medicine extract
One. prescription: Rhizoma Coptidis 103g Radix Astragali 154g Flos Lonicerae 618g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; It is 90% ethanol extraction 2 times that Rhizoma Coptidis, the Radix Astragali are used 10 times of amount concentration of volume percent, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.10 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 14 times of water gagings warm macerating 2 times under 90 ℃ of conditions, and each 0.5 hour, merge warm macerating liquid, be concentrated into that relative density is 1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I and is active component 169 grams of the present invention.
Embodiment 5: the preparation Chinese medicine extract
One. prescription: Rhizoma Coptidis 103g Radix Astragali 154g Flos Lonicerae 618g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; It is 80 ethanol extraction 2-3 time that Rhizoma Coptidis, the Radix Astragali are used 8 times of amount concentration of volume percent, and each 1.5 hours, merge extractive liquid, was concentrated into that relative density is 1.06 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 12 times of water gagings warm macerating 2 times under 60 ℃ of conditions, and each 1.5 hours, merge warm macerating liquid, be concentrated into that relative density is 1.06 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I and is active component 169 grams of the present invention.
Embodiment 6: the preparation Chinese medicine extract
One. prescription: Rhizoma Coptidis 103g Radix Astragali 154g Flos Lonicerae 618g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; It is 70% ethanol extraction 2 times that Rhizoma Coptidis, the Radix Astragali are used 8 times of amount concentration of volume percent, and each 2.5 hours, merge extractive liquid, was concentrated into that relative density is 1.08 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 10 times of water gagings warm macerating 2 times under 70 ℃ of conditions, and each 0.5-3 hour, merge warm macerating liquid, be concentrated into that relative density is 1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I and is active component 187 grams of the present invention.
Embodiment 7: the preparation Chinese medicine extract
One. prescription: Rhizoma Coptidis 103g Radix Astragali 154g Flos Lonicerae 618g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; It is 80% ethanol extraction 3 times that Rhizoma Coptidis, the Radix Astragali are used 10 times of amount concentration of volume percent, and each 1 hour, merge extractive liquid, was concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 10 times of water gagings warm macerating 3 times under 60 ℃ of conditions, and each 1 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I and is active component 168 grams of the present invention.
Embodiment 8: the preparation tablet
The active component 50g that embodiment 1 obtains adds dextrin 10g, lactose 10g, and sodium carboxymethyl cellulose 5g, tabletting gets tablet, and every is 0.25g.
Embodiment 9: the preparation capsule
Active component 1150 grams that embodiment 2 obtains.
Get this active component 1000g, add starch 200g, micropowder silica gel 10g, the encapsulating capsule, every is 0.30g.
Embodiment 10: zoopery
One. material
1. test material
1.1 laboratory animal:
The ICR mice, body weight 18～22g, male and female half and half, the pregnant Mus of Wiatar provides by Beijing Vital River Experimental Animals Technology Co., Ltd., the quality certification number: SCXK (capital) 2007-0001.
1.2 medicine and reagent:
JINQI JIANGTANG PIAN (commercially available article) and golden stilbene blood sugar lowering extract (preparation of embodiment 1 method) provide by Longshunrong Pharmaceutical Factory, Tianjin Zhongxin Pharmaceutical Group Co., Ltd.
Gold stilbene Jiangtang capsule, Jilin Aodong Yanbian Medicine Industry Co., Ltd
Gold stilbene hypoglycemic granule, the Henan Province Wanxi Pharmacy Stock Co., Ltd
Alloxan, Sigma company
Metformin hydrochloride tablet, Tianjin Pacific Pharmaceutical Co., Ltd.
Salt acid ratio lattice row ketone, Tianjin Pacific Pharmaceutical Co., Ltd.
The north, glucose Tianjin day medical chemistry chemical reagent work
L-sodium glutamate Beijing fragrant grass R&D firm
Give birth to control bio tech ltd in north in the glucose kit
1.3 instrument:
AA-800 type full automatic biochemical apparatus, Beijing Ai Erma medical electronic apparatus company limited
Two. method
2.1 influence to the diabetic mice of model induced by alloxan
2.1.1 the foundation of model
Get healthy nothing and hinder mice, fasting 24 hours, normal drinking-water, the tail vein once injects alloxan (40mg/kg) modeling respectively, and the administration volume is 0.1ml/10g.After (inject back 4 hours drink 5% sucrose solution to 32 hours) modeling 7 days to mice, fasting 16 hours, normal drinking-water, mice eyeground vein clump is got blood, uses determination of glucose oxidase blood glucose.Blood glucose value is higher than 200mg/dl and is regarded as the modeling success.
2.2.2 Drug therapy
Select 70 mices that blood glucose value is concentrated relatively among the above-mentioned modeling winner for use; Be divided into 7 groups at random: model control group, positive control metformin group (200mg/kg), JINQI JIANGTANG PIAN group, golden stilbene blood sugar lowering extract are low, high dose group, golden stilbene Jiangtang capsule group; Gold stilbene hypoglycemic granule group; Every group 10, give pure water, JINQI JIANGTANG PIAN (3.6g crude drug/kg), golden stilbene blood sugar lowering extract (1.8g crude drug/kg, 3.6 crude drugs/kg), golden astragalus capsules (3.6g crude drug/kg) respectively; (the 3.6g crude drug/kg), the administration volume is 0.2ml/10g to gold stilbene hypoglycemic granule.Successive administration 14 days, in the 7th, 14 day, the same method was measured blood glucose.Adopt the SPSS11.0 statistics, the result sees table 1.
2.2 influence to fat MSG rat carbohydrate tolerance
2.2.1 the foundation of model
Newborn rat is in being born subcutaneous injection L-sodium glutamate (4g/kg), blank group injection equivalent normal saline, continuous 7 days, ablactation after 21 days, periodic logging body weight, the variation of observation build, Cheng Mo after 3 months second day.
2.2.2 Drug therapy
Except that 10 of blank groups; 70 mices selecting for use blood glucose value among the above-mentioned modeling winner (determination of glucose oxidase blood glucose) to concentrate relatively; Be divided into 7 groups at random: model control group, positive control are lower than lattice row ketone group (20mg/kg), JINQI JIANGTANG PIAN group, golden stilbene blood sugar lowering extract, high dose group, golden stilbene Jiangtang capsule group, golden stilbene hypoglycemic granule group, 10 every group; Give pure water, JINQI JIANGTANG PIAN (3.6g crude drug/kg), golden stilbene blood sugar lowering extract (1.8g crude drug/kg, 3.6 crude drugs/kg) respectively; (the 3.6g crude drug/kg), (the 3.6g crude drug/kg), the administration volume is 0.2ml/10g to golden stilbene hypoglycemic granule to the gold astragalus capsules.Continuous 14 days, fasting was 16 hours before the last administration, normal drinking-water; Blood glucose when getting hematometry 0, the same administration, 1 as a child; The glucose (2.5g/kg) that gives with the filling stomach, measure the blood glucose value of giving sugar back 0.5h, 1h, 2h respectively; Calculate area under the blood glucose curve, adopt the SPSS11.0 statistics, the result sees table 2.
Three. the result
1. to the influence of the diabetic mice of model induced by alloxan
The influence of the diabetic mice of table 1. pair model induced by alloxan
Compare * P＜0.05 * * P＜0.01 with model control group
The result shows: JINQI JIANGTANG PIAN, golden stilbene blood sugar lowering extract, golden stilbene Jiangtang capsule and the administration of golden stilbene hypoglycemic granule all had effect (P＜0.05 of the blood glucose of the diabetic mice that reduces model induced by alloxan in 7 days and 14 days; P＜0.01); Under the same dose (the 3.6g crude drug/kg); The effect of gold stilbene blood sugar lowering extract slightly is superior to JINQI JIANGTANG PIAN, golden stilbene Jiangtang capsule and golden stilbene hypoglycemic granule, and is certain dose-effect relationship between low, the high dose.Prompting new technology gold stilbene blood sugar lowering extract multiple dosing has the effect that reduces experimental hyperglycemia.
2. to the influence of fat MSG rat carbohydrate tolerance
The influence of table 2. pair fat MSG rat carbohydrate tolerance
Compare △ △ P＜0.01 with the blank group; Compare * P＜0.05, * * P＜0.01 with model control group
Compare #P＜0.05 with JINQI JIANGTANG PIAN; Compare ※ P＜0.05 with golden stilbene hypoglycemic granule
The result shows: JINQI JIANGTANG PIAN, golden stilbene blood sugar lowering extract, golden stilbene Jiangtang capsule and 14 days equal prodigiosins of golden stilbene hypoglycemic granule administration obviously improve the impaired glucose tolerance of fat MSG rat; Make TG-AUC obviously reduce (P＜0.05; P＜0.01), (the 3.6g crude drug/kg), the effect of golden stilbene blood sugar lowering extract obviously is superior to JINQI JIANGTANG PIAN and golden stilbene hypoglycemic granule (P＜0.05) under the same dose; Slightly be superior to golden stilbene Jiangtang capsule, and be certain dose-effect relationship between low, the high dose.Prompting new technology gold stilbene blood sugar lowering extract multiple dosing has the effect that reduces experimental hyperglycemia, and drug effect is better than commercially available article JINQI JIANGTANG PIAN and golden stilbene hypoglycemic granule.
Claims (10)
1. the Chinese medicine composition of a heat clearing away QI invigorating, it is characterized in that: its active component is processed by the raw material of following parts by weight: 618 parts of 154 portions of Flos Loniceraes of 103 parts of Radixs Astragali of Rhizoma Coptidis.
2. the Chinese medicine composition of a kind of heat clearing away QI invigorating according to claim 1 is characterized in that said active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; Rhizoma Coptidis, the Radix Astragali use 6-10 doubly to measure concentration of volume percent to be the ethanol extraction of 50%-90% 2-3 time, and each 1-3 hour, merge extractive liquid, was concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 8-14 times of water gaging warm macerating 2-3 time under 50-90 ℃ of condition, and each 0.5-3 hour, merge warm macerating liquid, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I.
3. the Chinese medicine composition of a kind of heat clearing away QI invigorating according to claim 2 is characterized in that: said active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; Rhizoma Coptidis, the Radix Astragali use 8-10 doubly to measure concentration of volume percent to be the ethanol extraction of 60%-80% 2-3 time, and each 2-3 hour, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 10-12 times of water gaging warm macerating 2-3 time under 50-90 ℃ of condition, and each 1-2 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I.
4. the Chinese medicine composition of a kind of heat clearing away QI invigorating according to claim 3; It is characterized in that: said active component adopts following method to prepare: it is 80% ethanol extraction 2 times that Rhizoma Coptidis, the Radix Astragali are used 8 times of amount concentration of volume percent; Each 2 hours; Merge extractive liquid, is concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 10 times of water gagings warm macerating 2 times under 50-90 ℃ of condition, and each 1 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I.
5. according to the Chinese medicine composition of any one described a kind of heat clearing away QI invigorating in the claim 1 to 4, it is characterized in that: said pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
6. the Chinese medicine composition of a kind of heat clearing away QI invigorating according to claim 5 is characterized in that: said pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
7. the Chinese medicine composition of a kind of heat clearing away QI invigorating according to claim 5 is characterized in that: the dosage form of said Chinese medicine composition is a peroral dosage form, comprises pill, tablet, capsule or oral liquid.
8. the method for preparing of the Chinese medicine composition of a heat clearing away QI invigorating is characterized in that: take by weighing 618 parts of 154 portions of Flos Loniceraes of 103 parts of Radixs Astragali of Rhizoma Coptidis; Rhizoma Coptidis, the Radix Astragali use 6-10 doubly to measure concentration of volume percent to be the ethanol extraction of 50%-90% 2-3 time, and each 1-3 hour, merge extractive liquid, was concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 8-14 times of water gaging warm macerating 2-3 time under 50-90 ℃ of condition, and each 0.5-3 hour, merge warm macerating liquid, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I.
9. the method for preparing of the Chinese medicine composition of a kind of heat clearing away QI invigorating according to claim 8 is characterized in that: saidly take by weighing each raw material by proportioning raw materials; Rhizoma Coptidis, the Radix Astragali use 8-10 doubly to measure concentration of volume percent to be the ethanol extraction of 60%-80% 2-3 time, and each 2-3 hour, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 10-12 times of water gaging warm macerating 2-3 time under 50-90 ℃ of condition, and each 1-2 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I.
10. the method for preparing of the Chinese medicine composition of a kind of heat clearing away QI invigorating according to claim 8 is characterized in that: saidly take by weighing each raw material by proportioning raw materials; It is 80% ethanol extraction 2 times that Rhizoma Coptidis, the Radix Astragali are used 8 times of amount concentration of volume percent, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution A; Flos Lonicerae is with 10 times of water gagings warm macerating 2 times under 50-90 ℃ of condition, and each 1 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A and concentrated solution B are merged, and drying obtains dry thing I.
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Cited By (2)
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| CN105707896A (en) * | 2016-02-02 | 2016-06-29 | 武汉万德瑞生物技术有限公司 | Blood sugar lowering probiotic composition and preparation method and application thereof |
| WO2020187003A1 (en) * | 2019-03-21 | 2020-09-24 | 广东药科大学 | Use of oral preparation of jinqi jiangtang in preparation of drug for ulcerative colitis |
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| CN1965929A (en) * | 2006-11-01 | 2007-05-23 | 天津中新药业集团股份有限公司隆顺榕制药厂 | Preparation method of medicament for treating diabetes |
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| CN101695520A (en) * | 2008-12-30 | 2010-04-21 | 天津医科大学 | Preparation method of medicament for treating diabetes |
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| CN1559549A (en) * | 2004-03-12 | 2005-01-05 | 天津中新药业集团股份有限公司隆顺榕 | Medicine for treating diabetes and its preparation method |
| CN1923236A (en) * | 2005-09-01 | 2007-03-07 | 叶宏裕 | Jinqi antihypelipidemic drops and its preparation method |
| CN101172130A (en) * | 2006-10-31 | 2008-05-07 | 河南省宛西制药股份有限公司 | Jinqi sugar lowering condensed pill and preparation method thereof |
| CN1965929A (en) * | 2006-11-01 | 2007-05-23 | 天津中新药业集团股份有限公司隆顺榕制药厂 | Preparation method of medicament for treating diabetes |
| CN101695520A (en) * | 2008-12-30 | 2010-04-21 | 天津医科大学 | Preparation method of medicament for treating diabetes |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105707896A (en) * | 2016-02-02 | 2016-06-29 | 武汉万德瑞生物技术有限公司 | Blood sugar lowering probiotic composition and preparation method and application thereof |
| WO2020187003A1 (en) * | 2019-03-21 | 2020-09-24 | 广东药科大学 | Use of oral preparation of jinqi jiangtang in preparation of drug for ulcerative colitis |
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Application publication date: 20120704 |