CN1250267C - Health-care product for improving sleep and increasing bone density - Google Patents
Health-care product for improving sleep and increasing bone density Download PDFInfo
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- CN1250267C CN1250267C CNB011390603A CN01139060A CN1250267C CN 1250267 C CN1250267 C CN 1250267C CN B011390603 A CNB011390603 A CN B011390603A CN 01139060 A CN01139060 A CN 01139060A CN 1250267 C CN1250267 C CN 1250267C
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a health product for improving sleep and increasing bone density, which belongs to the technical field of health products. The health product of the present invention is composed of the following traditional Chinese drugs: fried jujube kernel, rehmannia root, fresh oyster shell, Radix Paeoniae Alba, wolfberry fruit, Chinese angelica, Radix Ophiopogonis, lily bulb, schizandra sinensis and lotus plumule as the active ingredients and other pharmaceutic adjuvants. In addition, the present invention also provides a preparation method.
Description
Technical field
The present invention relates to health product technology field.Be specifically related to a kind of health product that are used to improve sleep and bone density improving.
Background technology
People need sleep just as needs food and water, and insomnia is the formidable enemy of sleep.Cause the reason of insomnia a lot, environmental factors, medicine factor, Nervous and Mental Factors and bad life habits etc. are not only arranged, and insomnia also usually is the complication of numerous disease.Serious insomnia is usually tired, dizzy with spirit, headache, memory weaken, have palpitation, perspiration, emotional and depressed, flimsiness, a series of stiff reactions such as unsociable and eccentric.Neural functional disease---neurasthenia can occur year in and year out, directly influence insomniac's physical and mental health, therefore insomnia is subjected to people's attention and attention day by day.
At present, the medicine commonly used that is used for the treatment of the insomnia is stable, easily causes dependency, occur after the drug withdrawal perspiring tremble, insomnia, loss of appetite, symptom such as feel sick, other sleeping pill also have certain side effect.Chinese medicine adopts sedative more, is used for improving sleep.
Osteoporosis is a kind of disease that has a strong impact on quality of life.The sickness rate of osteoporosis accounts for 60% of aging population.It is an important indicator of osteoporosis that bone density reduces, and the main method that is used for bone density improving at present is to replenish the calcium, but has the problem that is difficult for absorption.
Summary of the invention
The objective of the invention is to adopt Chinese medicine, design a kind of health product that improve sleep and bone density improving.
The invention provides a kind of Chinese medicine health care product, these health product are made up of active ingredient and pharmaceutic adjuvant that Semen Ziziphi Spinosae (parched) 50-150 part, Radix Rehmanniae 50-150 part, Concha Ostreae 50-150 part, Radix Paeoniae Alba 50-150 part, Fructus Lycii 50-150 part, Radix Angelicae Sinensis 25-75 part, Radix Ophiopogonis, 25-75 part, Bulbus Lilii 20-60 part, Radix Schisandrae Bicoloris 20-60 part, Plumula Nelumbinis 10-30 part were made.
Can be made into oral formulations commonly used as oral liquid, capsule, tablet, pill etc.
The effect of main Chinese medicine is as follows in the composition of the present invention:
(1) Semen Ziziphi Spinosae (parched): health care with calm sleeping.Its main calm sleeping composition is a Semen Ziziphi Spinosae saponin;
(2) Radix Rehmanniae: it has the health care of calm sleeping, and the collaborative effect that improves class estrogen level in the body;
(3) Concha Ostreae: have functions such as the excitement of the nervous system of inhibition, enhancing immunity and bone density improving value, raising calcium phosphorus content.Composition: contain 80-95% calcium carbonate and trace element etc.;
(4) Radix Paeoniae Alba: have calm and immune system effect.Main component (functional component): peoniflorin;
(5) Fructus Lycii: have functions such as the recovery of enhancing immunity, defying age and promotion hemopoietic function and growth stimulation;
(6) Radix Angelicae Sinensis: have the hemoglobin of promotion, erythrocytic generation, brain is had calmness and improves the estrogen level effect;
(7) Radix Ophiopogonis: have functions such as enhancing immunity;
(8) Bulbus Lilii: have tranquilizing soporific, enhance immunity, resisting fatigue, anti-stress, cough-relieving, remove expectorant and function such as relieving asthma.
(9) Radix Schisandrae Bicoloris: have to functions such as central nervous system's inhibition and enhancing body adaptive capacitys.The traditional methods to keep in good health learns and to think the function of Radix Schisandrae Bicoloris tool supplementing QI for promoting the production of body fluid, kidney calming;
(10) Plumula Nelumbinis: have the effect of tranquilizing by nourishing the heart, main component is a liensinine.
The traditional methods to keep in good health studies the science to discuss and thinks: the effect modern pharmacology of the hard muscles and bones of tool kidney tonifying such as contained Fructus Lycii, Radix Schisandrae Bicoloris, Radix Rehmanniae, Radix Angelicae Sinensis, Concha Ostreae studies have shown that among the we: above all flavor material combination, have enhancing human body immunity power, regulate nervus centralis and hormonal system, reach the equilibrated effect of homergy that improves estrogen level, increase osteocyte activity, keeps human body osteogenesis and loss; Play the adjusting human body physiological function, improve the effect of sleep, bone density improving.
The present invention is safe, nontoxic through the toxicological test proof
To SD kind healthy white rat give 12.5,25.0 every day, 50.0ml.kg B.W dose product (be equivalent to recommended amounts 25,50,100 times), test period totally 30 days, final result is:
1. all physiology signs of rat, behavior, defecation, fur etc. are all no abnormal;
2. body weight and food utilization index are normal;
3. the blood routine index is normal;
4. biochemical indicator is normal;
5. each organ coefficient index is normal;
6. the outward appearance and the pathological examination of organs such as the heart, liver,spleen,kidney, small intestinal, testis, the no abnormal situation of result.
The present invention has the effect that improves sleep, bone density improving through effect experimentation proof.
With 5.0,10.0, this product continuous irrigation stomach mice of 15.0ml.kg B.W dosage 30 days, the result shows: each dosage group does not have obvious influence to the mice body weight, each dosage group can obviously shorten the inductive mice sleep of barbital sodium incubation period (P＜0.01), can spin out the inductive mouse sleep time of pentobarbital sodium (P＜0.01), can increase the inductive mice sleep incidence rate of sub-threshold dose barbital sodium (P＜0.01), this shows that this product has collaborative sleep effect with pentobarbital sodium, barbital sodium.
This product testing result that per os gives various dose shows, there were significant differences (P＜0.05) with the negative control group ratio for this product low dose group rat femur weight in wet base, dry weight, bone density and calcium content of bone, illustrates that this product of low dose group has the effect of bone density improving.
Therefore, the present invention has the sleep of improvement and bone density improving effect, has no adverse reaction and side effect.
Another object of the present invention has provided the above-mentioned preparation method that is used to improve the health product of sleep and bone density improving, and this method is that the medical material with formula ratio decocts with water twice, merges extracted twice liquid, and is centrifugal, concentrated, makes oral formulations according to a conventional method.
A further object of the present invention provides the application of above-mentioned health product in improving sleep and bone density improving.
Dosage every day that Chinese medicine health care product of the present invention is used to improve sleep and bone density improving is the oral dosage that is equivalent to crude drug 10.5-31.5g, divides and takes for 2-3 time.
The specific embodiment
Embodiment 1
Semen Ziziphi Spinosae (parched) 100kg, Radix Rehmanniae 100kg, Concha Ostreae 100kg, Radix Paeoniae Alba 100kg, Fructus Lycii 100kg, Radix Angelicae Sinensis 50kg, Radix Ophiopogonis, 50kg, Bulbus Lilii 40kg, Radix Schisandrae Bicoloris 40kg Plumula Nelumbinis 20kg added water 2800L, decocted, keep little and boiled 2 hours, filter, medicinal residues add water 2100L, decocted 1.5 hours, merging filtrate concentrates, centrifugal, dosing adds Mel, steviosin, regulate PH to 7.0-7.7, relative density is 1.09-1.12.Leaving standstill fill is that 15ml/ props up, moist heat sterilization, promptly.Instructions of taking, each 1, twice of every day.
Embodiment 2
Semen Ziziphi Spinosae (parched) 80kg, Radix Rehmanniae 110kg, Concha Ostreae 120kg, Radix Paeoniae Alba 80kg, Fructus Lycii 90kg, Radix Angelicae Sinensis 70kg, Radix Ophiopogonis, 70kg, Bulbus Lilii 40kg, Radix Schisandrae Bicoloris 60kg, Plumula Nelumbinis 20kg added water 2800L, decocted, keep little and boiled 2 hours, filter, medicinal residues add water 2100L, decocted 1.5 hours, merging filtrate concentrates, spray drying adds starch, mixes, granulate, vacuum drying, tabletting, promptly.
Embodiment 3
After 53 people took this product, sleep obviously improved, and soreness of waist and knee joint has improvement.Wherein: 36 people sleep and obviously improve, and no longer insomnia is easily sleeping, seldom wakes up with a start in the sleep; The 16 people improvement of sleeping, easily sleeping, to sleep to such an extent that the time is taken preceding length, number of times was few before the number of times of waking up in the sleep was taken; After taking together before 1 people takes, no significant difference; After 46 people reflection was taken, soreness of waist and knee joint had clear improvement.
Claims (4)
1. health product that are used to improve sleep and bone density improving, it is characterized in that these health product are made up of active ingredient and pharmaceutic adjuvant, wherein active component is to be made by the raw material of following weight ratio: Semen Ziziphi Spinosae (parched) 50-150 part, Radix Rehmanniae 50-150 part, Concha Ostreae 50-150 part, Radix Paeoniae Alba 50-150 part, Fructus Lycii 50-150 part, Radix Angelicae Sinensis 25-75 part, Radix Ophiopogonis 25-75 part, Bulbus Lilii 20-60 part, Radix Schisandrae Bicoloris 20-60 part, Plumula Nelumbinis 10-30 part.
2, a kind of health product that are used to improve sleep and bone density improving as claimed in claim 1 is characterized in that the weight ratio of wherein said active ingredient raw material is: 100 parts of Semen Ziziphi Spinosae (parched)s, 100 parts of Radix Rehmanniae, 100 parts of Concha Ostreae, 100 parts of the Radix Paeoniae Albas, 100 parts of Fructus Lycii, 50 parts of Radix Angelicae Sinensis, 50 parts of Radix Ophiopogonis, 40 parts of Bulbus Liliies, 20 parts of 40 parts of Plumula Nelumbiniss of Radix Schisandrae Bicoloris.
3. preparation method that is used to improve the health product of sleep and bone density improving as claimed in claim 1, it is characterized in that this method is that medical material with described weight proportion decocts with water twice, merge extracted twice liquid, centrifugal, concentrated, make oral formulations according to a conventional method.
4, the application of health product as claimed in claim 1 in improving sleep and bone density improving.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011390603A CN1250267C (en) | 2001-12-06 | 2001-12-06 | Health-care product for improving sleep and increasing bone density |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011390603A CN1250267C (en) | 2001-12-06 | 2001-12-06 | Health-care product for improving sleep and increasing bone density |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1422637A CN1422637A (en) | 2003-06-11 |
| CN1250267C true CN1250267C (en) | 2006-04-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011390603A Expired - Lifetime CN1250267C (en) | 2001-12-06 | 2001-12-06 | Health-care product for improving sleep and increasing bone density |
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| Country | Link |
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| CN (1) | CN1250267C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104770717A (en) * | 2015-04-13 | 2015-07-15 | 吉林省中研药业有限公司 | Healthcare product composition for soothing nerves and preparation method thereof |
| CN116059294A (en) * | 2023-02-07 | 2023-05-05 | 深圳太太药业有限公司 | Traditional Chinese medicine composition for improving sleep and increasing bone mineral density and product and preparation method thereof |
-
2001
- 2001-12-06 CN CNB011390603A patent/CN1250267C/en not_active Expired - Lifetime
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| Publication number | Publication date |
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| CN1422637A (en) | 2003-06-11 |
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