CN104770717A - Healthcare product composition for soothing nerves and preparation method thereof - Google Patents
Healthcare product composition for soothing nerves and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a healthcare product composition for soothing nerves and a preparation method thereof, and the present invention belongs to the field of healthcare products. The healthcare product composition for soothing nerves is prepared from the following materials in parts by weight: 20 to 30 parts of ginseng fruit saponins, 80 to 100 parts of white peony roots, 80 to 100 parts of angelica, 80 to 100 parts of spina date seeds and 140 to 160 parts of calcined oyster. According to diagnosis and treatment of insomnia based on syndrome differentiation and the traditional theories of healthcare, the healthcare product composition starts from nourishing blood, soothing nerves, tonifying heart and calming the nerves; chooses authentic medicine resources of the ginseng fruit saponins in Jilin province, combined with four Chinese herbal medicines (i.e. the peony root, the angelica, the spina date seeds and the calcined oyster) which can be used for healthcare food; and then uses a new method to prepare capsules or other dosage forms. The healthcare product composition has stable quality and very low toxic side effects; can be used to improve sleep; has effects of nourishing the blood, soothing the nerves, tonifying the heart and calming the nerves; can be used by people who have symptoms of palpitation, insomnia, dreaminess and tiredness and lack strength.
Description
Technical field
The invention belongs to field of health care products, refer in particular to a kind of for sedative health-care product.
Background technology
Modern medicine is roughly thought: sleep is a kind of active process, and sleep is the necessary rest that regains one's vigor, and has special maincenter management of sleep and awakening, and when sleeping, human brain has just changed a working method, enablely measures storage, is conducive to the recovery of spirit and muscle power; And suitable sleep is best rest, being the basis of maintaining healthy and muscle power, is also the guarantee obtaining height production capacity.And insomnia refers to fall asleep and maybe cannot keep sleep state, cause not having enough sleep, malaise, also known as DIMS.Along with socio-economic development and competition, sleep-disorder patient is in rising trend every year, an investigation of China's sleep study meeting shows, the insomnia rate of current domestic adult is up to 57%, work crowd has the people of 65% to there is sleep-disorder, and this ratio is considerably beyond developed countries such as America and Europes.Insomnia has been broken the rest of brain and health, has been revised and restore balance, increase the weight of spiritual pressure, and the generation of various diseases can be caused: insomnia makes cerebration receive impact, the power of arousing attention can not be concentrated, easily cause forgetful, make body be in sub-health state, chronic insomnia also easily causes aging, obesity, increase the occurrence risk of heart disease, hypertension, senile dementia, menopausal syndrome and the disease such as depression, anxiety disorder most serious of all, even can bring out palsy.
One of effective methods for the treatment of for insomnia is exactly Western medicine, and it has the advantages such as rapid-action, definite effect.At present, the Western medicine being used for the treatment of insomnia mainly contains benzodiazepine, Non-benzodiazepine medicine, melatonin class medicine and antidepressant etc.(1) benzodiazepine is current most popular somnifacient clinically.Benzodiazepine is mainly through selective antagonism 7-aminobutyric acid Benzodiazepine (GABA-BZDA) coreceptor, performance is calm, flesh is loose and anticonvulsant action, the effect that there is improving water flood structure, extend total sleep time, shorten Sleep latency, but this type of medicine easily has side effects, long-term taking benzodiazepine easily causes that psychomotor damages, memory disorders, the bad reaction such as rebound insomnia after drug addiction and withdrawal.(2) non-benzodiazepine sedative hypnotic drugs thing plays syngignoscism mainly through optionally bind receptor, structurally different from Benzodiazepines, both compare, sedative-hypnotic effect is close, but the side effects such as non-benzodiazepine agents produce insomnia bounce-back, abstinence syndrome, memory impairment are relatively little.(3) melatonin medicine is a kind of indole hormone of pineal body secretion, there is the effects such as hypnosis, calmness, adjustment sleep-wake cycle, be mainly used in sleep rhythm obstacle, comprise the caused sleep-disorder such as delayed sleep phase syndrome, jet lag, shift work, to senile insomnia, patient outcome is better.But there are some researchs to think the hypnotic effect of melatonin medicine imprecise, and the secretion of endogenous melatonin can be suppressed when exceeding physiological dose, have and increase the weight of depressed effect.Some antidepressant such as amitriptyline, doxepin, nefazodone and Mirtazapine etc. also have improving water flood effect, but long-term taking easily produces the bad reactions such as tired, dizzy, sleepy.
In China's " food industry " 12 " development plan ", first " nutrition and health care food manufacturing " is listed in national development planning.According to this planning, developing direction and emphasis for nutrition and health care food manufacturing: " greatly developing natural, green, environmental protection, safely and effectively food, health food and special diet food "; " to keep healthy theory in conjunction with traditional methods to keep in good health, make full use of the health food that the peculiar animal and plant resource of China and technological development have national characters and New function ".In Chinese health product raw material, mainly contain plant, animal class, Mycophyta, prebiotic mushroom, bioactivator class are several, health products kind relative abundance, but the health care distribution that product is declared is concentrated, there is simple plagiarism and low-level repetition phenomenon, this will make health food enterprise operation be absorbed in homogeneity harmful competition, and then affect the sound development of Health-care Foods Industry.Enterprise how is guided to use new technology, new technology, strengthens the research to health food active ingredient, and research and development have the functional product of local characteristic, strengthen exploitation to New function, new raw material, new product, advance health food to enter the research and development of deep layer etc. urgently to be resolved hurrily.
Summary of the invention
The invention provides a kind of Halth-care composition for calming the nerves and preparation method thereof, for improving water flood function.
The technical scheme that the present invention takes is: be made up of the raw material of following weight portion:
Herba Herminii saponin 20 ~ 30 parts, the root of herbaceous peony 80 ~ 100 parts, Radix Angelicae Sinensis 80 ~ 100 parts, spina date seed 80 ~ 100 parts, calcined oyster shell 140 ~ 160 parts.
Preferred:
Herba Herminii saponin 25 parts, the root of herbaceous peony 90 parts, Radix Angelicae Sinensis 90 parts, spina date seed 90 parts, calcined oyster shell 150 parts.
The preparation method of inventive compound comprises the following steps:
(1) get the spina date seed in formula, calcined oyster shell two taste pulverizing medicinal materials becomes fine powder;
(2) root of herbaceous peony, Radix Angelicae Sinensis two taste first time add the water soaking 1 ~ 2 hour of 6 ~ 8 volume times amount, decoct 2 ~ 3 hours, filtration, second time adds the soak by water 1 ~ 2 hour of 4 ~ 6 volume times amount, filter, merging filtrate, surveying relative density when filtrate is concentrated into 80 DEG C is the thick paste of 1.30 ~ 1.32;
(3) thick paste is added above-mentioned spina date seed, calcined oyster shell fine powder, mixing, dry, pulverize into fine powder, sieves;
(4) in above-mentioned fine powder, add Herba Herminii saponin's mixing.
The present invention can be prepared into various formulation according to a conventional method, preferred capsule, and method is mixed with appropriate amount of starch auxiliary material by active constituents of medicine, granulates, dry, and whole grain is encapsulated, every dress 0.3g.
According to theory of traditional Chinese medical science, the present invention has selected the five tastes such as Herba Herminii saponin, the root of herbaceous peony, Radix Angelicae Sinensis, spina date seed, calcined oyster shell to can be used for the Chinese medicine of health food, wherein Herba Herminii saponin has tonifying five zang organs, pacifies spiritual, to determine soul, only palpitation with fear, the happy intelligence development of improving eyesight effect, the root of herbaceous peony has nourishing blood and liver, pain relieving in slow, astringe yin receives sweat effect, and Radix Angelicae Sinensis has the effect of enriching blood and invigorating blood circulation, the root of herbaceous peony is auxiliary panax ginseng fruit conditioning human body normal circulation of qi and blood together with Radix Angelicae Sinensis, strengthens nourishing blood and tranquilization, the calm function of the peaceful heart; Spina date seed has nourishing the liver, Ning Xin, calms the nerves, sweat restrain action, and calcined oyster shell has tranquilizing and allaying excitement, checking exuberance of yang tonifying yin, and softening and resolving hard mass restrains astringent or styptic treatment for spontaneous sweating function, and spina date seed and calcined oyster shell have the effect of tranquilizing and allaying excitement, assists panax ginseng fruit, the root of herbaceous peony and Radix Angelicae Sinensis to strengthen health care.
The present invention is according to traditional Health preserving theory, to the diagnosis and treatment of insomnia, from nourishing blood and tranquilization, peaceful heart calmness is started with, the genunie medicinal materials resource Herba Herminii saponin in first-selection Jilin Province, the compatibility root of herbaceous peony, Radix Angelicae Sinensis, spina date seed, calcined oyster shell four taste can be used for the Chinese medicine of health food, use new method, are prepared into capsule or other formulation, steady quality, toxic and side effect is very little, can be used for improving water flood, have nourishing blood and tranquilization, the health care of peaceful heart calmness, for palpitation and insomnia, then dreaminess of sleeping, the crowds such as lassitude hypodynamia use.
Detailed description of the invention
The preparation of embodiment 1 capsule
Herba Herminii saponin 20g, root of herbaceous peony 80g, Radix Angelicae Sinensis 80g, spina date seed 80g, calcined oyster shell 140g;
(1) get the spina date seed in formula, calcined oyster shell two taste pulverizing medicinal materials becomes fine powder;
(2) root of herbaceous peony, Radix Angelicae Sinensis two taste first time add the water soaking 1 hour of 6 volume times amount, decoct 2 hours, filter, and second time adds the soak by water 1 hour of 4 volume times amount, filters, merging filtrate, and when filtrate is concentrated into 80 DEG C, survey relative density is the thick paste of 1.30;
(3) thick paste is added above-mentioned spina date seed, calcined oyster shell fine powder, mixing, dry, pulverize into fine powder, sieves;
(4) in above-mentioned fine powder, add Herba Herminii saponin's mixing;
(5) said medicine active component is mixed with appropriate amount of starch auxiliary material, granulate, dry, whole grain, encapsulated, every dress 0.3g.
The preparation of embodiment 2 capsule
Herba Herminii saponin 25g, root of herbaceous peony 90g, Radix Angelicae Sinensis 90g, spina date seed 90g, calcined oyster shell 150g;
(1) get the spina date seed in formula, calcined oyster shell two taste pulverizing medicinal materials becomes fine powder;
(2) root of herbaceous peony, Radix Angelicae Sinensis two taste first time add the water soaking 1 hour of 8 volume times amount, decoct 3 hours, filter, and second time adds the soak by water 2 hours of 6 volume times amount, filters, merging filtrate, and when filtrate is concentrated into 80 DEG C, survey relative density is the thick paste of 1.31;
(3) thick paste is added above-mentioned spina date seed, calcined oyster shell fine powder, mixing, dry, pulverize into fine powder, sieves;
(4) in above-mentioned fine powder, add Herba Herminii saponin's mixing;
(5) said medicine active component is mixed with appropriate amount of starch auxiliary material, granulate, dry, whole grain, encapsulated, every dress 0.3g.
The preparation of embodiment 3 capsule
Herba Herminii saponin 30g, root of herbaceous peony 100g, Radix Angelicae Sinensis 100g, spina date seed 100g, calcined oyster shell 160g;
(1) get the spina date seed in formula, calcined oyster shell two taste pulverizing medicinal materials becomes fine powder;
(2) root of herbaceous peony, Radix Angelicae Sinensis two taste first time add the water soaking 2 hours of 7 volume times amount, decoct 2.5 hours, filter, and second time adds the soak by water 1.5 hours of 5 volume times amount, filters, merging filtrate, and when filtrate is concentrated into 80 DEG C, survey relative density is the thick paste of 1.32;
(3) thick paste is added above-mentioned spina date seed, calcined oyster shell fine powder, mixing, dry, pulverize into fine powder, sieves;
(4) in above-mentioned fine powder, add Herba Herminii saponin's mixing;
(5) said medicine active component is mixed with appropriate amount of starch auxiliary material, granulate, dry, whole grain, encapsulated, every dress 0.3g.
The preparation of embodiment 4 tablet
Herba Herminii saponin 20g, root of herbaceous peony 80g, Radix Angelicae Sinensis 80g, spina date seed 80g, calcined oyster shell 140g;
(1) get the spina date seed in formula, calcined oyster shell two taste pulverizing medicinal materials becomes fine powder;
(2) root of herbaceous peony, Radix Angelicae Sinensis two taste first time add the water soaking 2 hours of 6 volume times amount, decoct 2 hours, filter, and second time adds the soak by water 1 hour of 4 volume times amount, filters, merging filtrate, and when filtrate is concentrated into 80 DEG C, survey relative density is the thick paste of 1.30;
(3) thick paste is added above-mentioned spina date seed, calcined oyster shell fine powder, mixing, dry, pulverize into fine powder, sieves;
(4) in above-mentioned fine powder, add Herba Herminii saponin's mixing;
(5) said medicine active component is mixed with appropriate amount of starch auxiliary material, granulate, dry, whole grain, compressing tablet, the heavy 0.3g of every sheet.
The preparation of embodiment 5 tablet
Herba Herminii saponin 25g, root of herbaceous peony 90g, Radix Angelicae Sinensis 90g, spina date seed 90g, calcined oyster shell 150g;
(1) get the spina date seed in formula, calcined oyster shell two taste pulverizing medicinal materials becomes fine powder;
(2) root of herbaceous peony, Radix Angelicae Sinensis two taste first time add the water soaking 2 hours of 8 volume times amount, decoct 3 hours, filter, and second time adds the soak by water 2 hours of 6 volume times amount, filters, merging filtrate, and when filtrate is concentrated into 80 DEG C, survey relative density is the thick paste of 1.31;
(3) thick paste is added above-mentioned spina date seed, calcined oyster shell fine powder, mixing, dry, pulverize into fine powder, sieves;
(4) in above-mentioned fine powder, add Herba Herminii saponin's mixing;
(5) said medicine active component is mixed with appropriate amount of starch auxiliary material, granulate, dry, whole grain, compressing tablet, the heavy 0.3g of every sheet.
The preparation of embodiment 6 tablet
Herba Herminii saponin 30g, root of herbaceous peony 100g, Radix Angelicae Sinensis 100g, spina date seed 100g, calcined oyster shell 160g;
(1) get the spina date seed in formula, calcined oyster shell two taste pulverizing medicinal materials becomes fine powder;
(2) root of herbaceous peony, Radix Angelicae Sinensis two taste first time add the water soaking 1.5 hours of 6 volume times amount, decoct 2.5 hours, filtration, second time adds the soak by water 1.5 hours of 5 volume times amount, filter, merging filtrate, surveying relative density when filtrate is concentrated into 80 DEG C is the thick paste of 1.32;
(3) thick paste is added above-mentioned spina date seed, calcined oyster shell fine powder, mixing, dry, pulverize into fine powder, sieves;
(4) in above-mentioned fine powder, add Herba Herminii saponin's mixing;
(5) said medicine active component is mixed with appropriate amount of starch auxiliary material, granulate, dry, whole grain, compressing tablet, the heavy 0.3g of every sheet.
Further illustrate effect of the present invention by pharmacodynamic experiment below, the present invention is hereinafter referred to as ginseng fruit claming capsule.
1, test material
Animal used as test: ICR small white mouse, body weight 18-21g male and female half and half; SD big white mouse body weight 180-220g male and female half and half.All rats, small white mouse are all purchased from the high-new medical experiment Animal Research Center in Changchun.
Trial drug: ginseng fruit claming capsule, Jilin Grinds Medicine Job Ltd.in The Province provides, lot number: 130601, patent medicine specification: 0.3g/ grain, and every, containing raw medicinal herbs 0.445g, is made into desired concn with distilled water during test for oral administration.Sedative jujube kernel capsule, Guizhou Tongjitang Pharmaceutical Co., Ltd produces, lot number: 130108.Scopolamine hydrobromide injection, Shanghai Hefeng Pharmaceutical Co., Ltd. produces, lot number 130210.
2, method and result
2.1 impacts on spontaneous activity in mice: mouse 50, random point 5 groups, gastric infusion or isometric(al) physiological saline 0.2ml/10g1 time.After 1 hour, in observed and recorded 2min, mouse walking time and two forelimb upwards praise number of times, the results are shown in Table 1.
Table 1 joins fruit claming capsule to the impact (X ± S) of spontaneous activity in mice
* P < 0.05, * * P < 0.01 is compared with control group
Result shows, ginseng fruit claming capsule can reduce on mouse walking time and forelimb lifts number of times,
2.2 hypnosis test
2.2.1 sleep laboratory: mouse 50, random point 5 groups, gastric infusion or isometric(al) physiological saline 0.2ml/10g2 time, 4 hours, interval, behave with mouse more than righting reflex loss 1min and to sleep index, each group sleep number of mice in 2 hours after the administration of record last, after the administration of result ginseng fruit claming capsule each dosage group mouse, righting reflex all exists.
2.2.2 on the impact of threshold dose yellow Jackets syngignoscism: mouse 50 points 5 groups at random, gastric infusion or isometric(al) physiological saline 0.2ml/10g1 time.Injection yellow Jackets 50mg/kg in each mouse peritoneal after 1 hour, is Sleep latency from injection yellow Jackets righting reflex loss required time, is sleep time, the results are shown in Table 2 from righting reflex loss to the time that it recovers.
Table 2 joins fruit claming capsule to the impact (X ± S) of threshold dose yellow Jackets syngignoscism
* P < 0.05, * * P < 0.01 is compared with control group
Result shows, ginseng fruit claming capsule shortens the mice sleep incubation period of threshold dose yellow Jackets induction, and extend the length of one's sleep, sedative jujube kernel capsule also can extend the mouse sleep time of yellow Jackets induction, but has no significant effect Sleep latency.
2.2.3 on the impact of sub-threshold dose yellow Jackets effect: mouse 50 points 5 groups at random, gastric infusion or isometric(al) physiological saline 0.2ml/10g1 time.Injection yellow Jackets 28mg/kg in each mouse peritoneal after 1 hour, to behave index of sleeping with mouse more than righting reflex loss 1min, records each group of sleep number of mice, calculate sleep percentage, the results are shown in Table 3.
Table 3 joins fruit claming capsule to the impact (X ± S) of sub-threshold dose yellow Jackets syngignoscism
* P < 0.05, * * P < 0.01 is compared with control group
Result shows, ginseng fruit claming capsule can strengthen sub-threshold dose yellow Jackets syngignoscism, and sedative jujube kernel capsule also can strengthen sub-threshold dose yellow Jackets syngignoscism.
2.3 Improving memory power test (darkness avoidance test)
Mouse 50, random point 5 groups, gastric infusion or isometric(al) physiological saline, every day 1 time, continuous 10 days.Start training the 9th day morning, before training, 20min respectively organizes injection scopolamine hydrobromide injection 2mg/kg in mouse peritoneal and causes impaired memory model, then mouse is put into camera-lucida training 5min.Mouse, after 1 hour, is put into camera-lucida by last gastric infusion again, and record mouse to enter incubation period and the 5min errors number of camera bellows to getting into the cave Zi putting into camera-lucida, the results are shown in Table 4.
Table 4 is joined fruit claming capsule and is caused the acquired amnemonic impact (X ± S) of mouse to hyoscine
* P < 0.05, * * P < 0.01 is compared with control group
From table 4, ginseng fruit claming capsule can extend mouse and get into the cave and enter the incubation period of camera bellows, reduces errors number, illustrates ginseng really claming capsule the acquired memory disorders of mouse caused to hyoscine be improved effect.Sedative jujube kernel capsule causes the acquired memory disorders of mouse to hyoscine and is also improved effect.
3, results of pharmacodynamic test shows, ginseng fruit claming capsule shortens the incubation period of threshold dose yellow Jackets inducing mouse, extends the length of one's sleep, strengthens the sleep effect of sub-threshold dose yellow Jackets; The acquired memory disorders of mouse are caused to hyoscine and is improved effect.Result of the test illustrates that ginseng fruit claming capsule has calmness, calms the nerves, the effect of Improving memory power.
Claims (3)
1. the Halth-care composition for calming the nerves, is characterized in that: be made up of the raw material of following weight portion:
Herba Herminii saponin 20 ~ 30 parts, the root of herbaceous peony 80 ~ 100 parts, Radix Angelicae Sinensis 80 ~ 100 parts, spina date seed 80 ~ 100 parts, calcined oyster shell 140 ~ 160 parts.
2. a kind of Halth-care composition for calming the nerves according to claim 1, is characterized in that: be made up of the raw material of following weight portion:
Herba Herminii saponin 25 parts, the root of herbaceous peony 90 parts, Radix Angelicae Sinensis 90 parts, spina date seed 90 parts, calcined oyster shell 150 parts.
3. the preparation method of a kind of Halth-care composition for calming the nerves as claimed in claim 1 or 2, is characterized in that comprising the following steps:
(1) get the spina date seed in formula, calcined oyster shell two taste pulverizing medicinal materials becomes fine powder;
(2) root of herbaceous peony, Radix Angelicae Sinensis two taste first time add the water soaking 1 ~ 2 hour of 6 ~ 8 volume times amount, decoct 2 ~ 3 hours, filtration, second time adds the soak by water 1 ~ 2 hour of 4 ~ 6 volume times amount, filter, merging filtrate, surveying relative density when filtrate is concentrated into 80 DEG C is the thick paste of 1.30 ~ 1.32;
(3) thick paste is added above-mentioned spina date seed, calcined oyster shell fine powder, mixing, dry, pulverize into fine powder, sieves;
(4) in above-mentioned fine powder, add Herba Herminii saponin's mixing.
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