CN101444583A - Medicament for curing neurasthenia - Google Patents
Medicament for curing neurasthenia Download PDFInfo
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- CN101444583A CN101444583A CNA2008100798730A CN200810079873A CN101444583A CN 101444583 A CN101444583 A CN 101444583A CN A2008100798730 A CNA2008100798730 A CN A2008100798730A CN 200810079873 A CN200810079873 A CN 200810079873A CN 101444583 A CN101444583 A CN 101444583A
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Abstract
The invention relates to a medicament for curing neurasthenia. The medicament is prepared by taking glossy ganoderma, Chinese angelica, manyprickle acanto-panax root, spina date seed, Chinese wolfberry, and the like, as bulk drugs, adding water, carrying out decoction and concentrating the boiled liquid into thick paste which is crushed and then packed into capsules. The medicament has the functions of tonifying the liver and kidney, calming the heart and tranquilizing the mind and filling the marrow and strengthening the brain, is used for the symptoms, such as dizziness, tiredness, cardiopalmus, morbid forgetfulness, insomnia, dreaminess and sored waist and knee, and the like, which are caused by liver and kidney damage, can relieve various symptoms caused by the neurasthenia, achieves the cure rate of 36 percent and the total efficiency of 95 percent according to the statistics of 100 clinical neurasthenia cases.
Description
Technical field
The present invention relates to a kind of medicine, being specifically related to a kind of is the neurasthenic medicine of treatment of feedstock production with the Chinese crude drug, the invention still further relates to the preparation method of this medicine.
Background technology
The neurasthenia mainly shows as the imbalance of brain higher nervous activity, and be characterized in normal sensation mentality and be short of physical strength, fatiguability, work efficiency is low, exists but there is organic disease.Various incompatibility symptoms can appear clinically, as dizzy, feel dizzy, sore waist and aching in the waist and the back, fidgetyly easily pardon, difficulty falling asleep, dreaming often and waking easily, forgetful, premature ejaculation sexual impotence, can be with slight depression or anxiety.Data shows that work, study hypertonicity are acted hurriedly in a messy situation, and it is irregular to have a rest and sleep, and operating pressure is big, and health is in subhealth state, and feels to have burden and offending emotion etc., is to cause neurasthenic principal element.
The western medical treatment neurasthenia mainly relies on to stabilize and waits the tranquilizer symptomatic treatment of sleeping peacefully, but there is defective in these medicines aspect safety and the dependency, and side effect is bigger, forms addiction, drug resistance easily, so should not take for a long time.
Summary of the invention
The purpose of this invention is to provide a kind of neurasthenic Chinese Traditional Medicines that are used for the treatment of, but this medicine liver and kidney tonifying, mind tranquilizing and the heart calming is used for diseases such as the dizzy asthenia of Liver and kidney side due to decreasing, palpitation and amnesia, insomnia and dreamful sleep, soreness of the waist and knees.
Motherland's Traditional Chinese medical theory thinks, heart governing blood and vessels and house mind, and liver is that the sea of blood is hidden soul, and kidney spermatogenesis marrow and hide will has only the essence and blood abundance, and the two things diametrically opposed to each other heart is foster to some extent, and soul is hidden will benefit to some extent to some extent, can make refreshing Anginin, and brain is good for will acute hearing.Brain overwork is considered sad spleen, or exhaustion due to sexual indulgence hinders essence and blood consumption is hindered, and the heart is lost blood foster, and liver-fire blood is hidden, and deficiency of kidney-essence can not be supplemented nutrition in brain, neurasthenia then, and all diseases are from life.So liver and kidney tonifying, mind tranquilizing and the heart calming, fill the marrow brain-strengthening for the treatment neurasthenic main aim.
Based on above-mentioned Therapeutic Principle, medicine of the present invention is that the Chinese medicine by following ratio of weight and number is that crude drug prepares:
Ganoderma 5～20 Radix Angelicae Sinensis 5～20
Radix Et Caulis Acanthopanacis Senticosi 5～20 Semen Ziziphi Spinosaes 20～40
Fructus Lycii 5～20 Radix Polygalaes 5～20
Radix Polygoni Multiflori 5～20 Herba Epimedii 5～20
Rhizoma Dioscoreae 10～30.
The medicine of above-mentioned each component can be made said dosage form on any pharmaceuticss such as tablet, pill, granule, capsule, and the preferred dosage form of the present invention is a capsule.
The concrete preparation method of above-mentioned each component being made medicine of the present invention is:
With above-mentioned various medicines according to described parts by weight mix homogeneously, decoct with water 3 times, each 0.5～1 hour, merge 3 times decocting liquid, filter, being condensed into relative density is the thick paste of 1.25～1.3 (60 ℃), after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, sterilization makes the capsule product in incapsulating.
Mostly Chinese medicine is compound preparation, is particular about monarch.The monarch and his subjects' the gas of building up one's health by taking tonic nourishes blood, YIN nourishing and the production of body fluid promoting, and adjuvant drug is soothing the liver, spleen invigorating, the kidney invigorating, strengthens liver spleen renal function, just can obtain the curative effect of fair marrow brain-strengthening.In the medicament composing prescription of the present invention, select Ganoderma for use and work as the monarch drug that is classified as benefiting qi and nourishing blood.Ganoderma is the king in the bacterium, have the good reputation of " Herba mesonae chinensis ", is had an inhibition tumor by universally acknowledged, strengthens body immunity, effects such as slow down aging.The glycoside in the Ganoderma and the KD factor can strengthen function of human body, prevent insomnia, and ganoderan can promote the human body diploid cell and DNA is synthetic and the brain cell metabolism, improves the cardiac and cerebral blood-supply circulation, regulates the organism endocrine effect.The Radix Angelicae Sinensis benefiting qi and nourishing blood protects the liver tonification.Medicament composing prescription of the present invention is with Radix Et Caulis Acanthopanacis Senticosi, Semen Ziziphi Spinosae, Fructus Lycii, Radix Polygalae vital energy benefiting and the kidney invigorating, YIN nourishing and the production of body fluid promoting, and heart tonifying is a ministerial drug, wherein Radix Et Caulis Acanthopanacis Senticosi has vital energy benefiting and the kidney invigorating, bone and muscle strengthening, resisting fatigue, resisting oxygen lack; The Semen Ziziphi Spinosae tranquilizing and blood nourishing, be used for restless, insomnia and dreamful sleep, the palpitation with fear etc.; The Fructus Lycii nourishing liver and kidney has the function that strengthens the T lymphocyte, can antitumor, and slow down aging improves body immunity; Radix Polygalae has calmness, calms the nerves, and promotes the effect of muscle power and intelligence, and stronger anticonvulsant action is arranged.Medicament composing prescription of the present invention is also with Radix Polygoni Multiflori, Herba Epimedii enriching yin and nourishing kidney, strengthening yang and invigorating kidney, and soothing liver and strengthening spleen is an adjuvant drug, the Radix Polygoni Multiflori enriching yin and nourishing kidney, strengthening bone and muscle is used for soreness of the waist and knees, dizzy asthenia etc.; Herba Epimedii has strengthening yang and invigorating kidney, bone and muscle strengthening, the effect of soothing liver and strengthening spleen.Rhizoma Dioscoreae can beneficial essence be reinforced the kidney, and assists all medicines to coordinate with the negative and positive of kidney, is used for the treatment of the neurasthenia, removes brain fag, and building body is used as messenger drug in medicament composing prescription of the present invention.
Medicine of the present invention include multiplely calm the nerves, calm specially good effect composition and brain healthy, the nutrient substance that regains one's strength of body, can significantly regulate metabolic disorder of cranial nerve, remove brain fag, regain one's strength of body fast, have the double effects of treatment and health care.
Through clinical verification, medicine of the present invention has liver and kidney tonifying, mind tranquilizing and the heart calming, fills the function of marrow brain-strengthening, be used for diseases such as the dizzy asthenia of Liver and kidney side due to decreasing, palpitation and amnesia, insomnia and dreamful sleep, soreness of the waist and knees, can effectively alleviate the various symptoms that caused by the neurasthenia, be the ideal medicament that the treatment neurasthenia waits disease.
Drug administration of the present invention is convenient, and is without any side effects.
By medicine of the present invention is carried out pharmacology, toxicologic study, obtain as drawing a conclusion:
1, study, memory function experiment: give mice continuous oral 0.6～1.5g/kg medicine of the present invention, can make animal due to the scopolamine be subjected to diving tower/lost training study, memory acquisition disturbance be improved significantly, and present output-effect relationship, point out medicine of the present invention to have the intelligence development functions that improves memory.
2, collaborative pentobarbital sodium syngignoscism experiment: irritate the medicine of the present invention that dosage is stated on the Weishang to its mouse oral continuously, obviously prolonged the length of one's sleep of pentobarbital sodium, the amount of having-effect relationship points out medicine of the present invention to have stable, sedation that more collaborative maincenter suppresses simultaneously.
3, antagonism strychnine induced mice acute poisoning causes death and tests: the medicine of the present invention of dosage is stated on the continuous irrigation Weishang, can obviously prolong animal to the acute lethal time-to-live of antagonism strychnine, and dose dependent is arranged, point out medicine of the present invention to have stronger antagonism central stimulants action function.
4, mice swimming test and normal pressure anoxia enduring experiment: medicine of the present invention can make mice swimming with a load attached to the body time and normobaric hypoxia time-to-live obviously prolong, and the amount of having-effect relationship, points out medicine of the present invention to have antistress function.
5, antagonism mice chemical anoxia experiment: give the medicine of the present invention of above-mentioned each dosage continuously, can make NaNO
2The time-to-live of poisoning animal obviously prolongs, and shows that the damage that medicine of the present invention causes chemical hypoxia has stronger antagonism.
6, mtd test: most during the amount of receiving greatly 48g/kg (quite crude drug in whole 345.6g/kg), any toxic reaction do not occur, the most amount of receiving greatly that shows drug oral administration of the present invention is 48g/kg (is equivalent to the clinical consumption of people 1920 times).
7, long term toxicity test: dosage was respectively 3g/kg, 4.5g/kg continuous irrigation stomach 90 days (be equivalent to people's consumption 120 times, 180 times), general situation, body weight, blood routine and the biochemistry of animal, the equal no significant difference of each main organs histopathology point out medicine prolonged application of the present invention not produce tissue and functional lesion as a result.
Henan Province's Chinese medicine institute, Henan Prov. People's Hospital use medicament capsule of the present invention the neurasthenia have been carried out clinical treatment, 100 routine clinical cases added up, and cure rate 36%, total effective rate 95% proves that curative effect of medication of the present invention is definite.
One, case is selected
Neurasthenic diagnostic criteria is as follows:
1, dizzy, the murky or dizzy uncomfortable person of typical case is arranged; 2, hypomnesis or forgetful; 3, the classical symptom that has insomnia: difficulty falling asleep, awakening often, sleep and unstable or wake up after can not sleep again, wake up morning too early, can not fall asleep night, lethargy on daytime was not had enough sleep 5 hours; 4, cardiopalmus or vexed uneasiness, sore waist and aching in the waist and the back, anorexia.
Get rid of insomnia, the dizzy patient have organ lesion and disease to cause, allly meet above diagnostic criteria person and can include the test case in.Select 130 examples altogether for use, male 54 examples, women 76 examples, the mean age is 38 years old, all case all meets diagnostic criteria.Be divided into two groups at random, 100 examples are organized in treatment, matched group 30 examples.
Table 1 treatment group and matched group clinical data are relatively
Two, Therapeutic Method
Treatment is organized 100 examples and is taken medicament capsule of the present invention, and each 2, every day 3 times, 30 days courses of treatment.
Matched group 30 examples are taken the JIANNAOLING PIAN that the effluent south Kaifeng pharmaceutical factory of traditional Chinese medicine produces, each 5, every day 3 times, 30 days courses of treatment.
Three, curative effect determinate standard
Cure: transference cures such as dizzy asthenia, hypomnesis, cardiopalmus, inappetence, recover the length of one's sleep normal or the nighttime sleep time more than 6 hours, sleep is dull, the back of waking up is hale and hearty;
Produce effects: dizzy asthenia, hypomnesis, cardio palmus shape obviously alleviate, and sleep takes a turn for the better, and increase the length of one's sleep more than 3 hours, and Depth of sleep increases;
Effectively: dizzy asthenia, hypomnesis, cardiopalmus alleviate, treat preceding less than 3 hours that increase the length of one's sleep;
Invalid: symptoms such as dizzy asthenia, hypomnesis, insomnia, cardiopalmus, the tired power of body do not have improvement or increase the weight of.
Four, therapeutic outcome
1, the dull-witted table of paddy long river (HDS) mensuration changes before and after the treatment
By the dull-witted table of paddy long river medicine of the present invention is measured with the therapeutic effect of JIANNAOLING PIAN treatment front and back and to be kept the score.The result shows that relatively there were significant differences (p＜0.01) before and after the treatment of treatment group, and more also there were significant differences for treatment group and matched group (p＜0.05).
The dull-witted table mensuration of paddy long river variation before and after table 2 is treated (X ± SD)
* compare P＜0.05 with matched group
2, immediate memory is measured variation before and after the treatment
Therapeutic effect before and after the treatment of medicine of the present invention and JIANNAOLING PIAN is measured kept the score by establishing block-regulations, the result shows that there were significant differences (P＜0.01) before and after the treatment of treatment group, and more also there were significant differences for treatment group and matched group (P＜0.05).
Immediate memory mensuration variation before and after table 3 treatment (XS ± D)
* compare p＜0.05 with matched group
3, the total effects before and after the treatment relatively
Treatment is organized in 100 examples, clinical cure 36 examples (accounting for 36%), produce effects 32 examples (accounting for 32%), effective 27 examples (accounting for 27 examples), invalid 5 examples (accounting for 5%), total effective rate 95%; In matched group 30 examples, clinical cure 4 examples (accounting for 13%), produce effects 9 examples (accounting for 30%), effective 13 examples (accounting for 43%), invalid 4 examples (accounting for 13%), total effective rate 87%.The treatment group is better than matched group, and there were significant differences in both statistical dispositions (p＜0.05).
Table 4 liang group total effects relatively
Five, clinical conclusion
1, confirms that through clinical observation medicine of the present invention has the neurasthenic effect of good curing.
2, safety detects and confirms that Department of Pharmacy of the present invention safe drugs is not found toxic and side effects before and after treatment.
3, during taking medicine of the present invention, any untoward reaction does not appear.
The specific embodiment
Embodiment 1
Take by weighing Ganoderma 150g, Radix Angelicae Sinensis 150g, Radix Et Caulis Acanthopanacis Senticosi 150g, Semen Ziziphi Spinosae 300g, Fructus Lycii 150g, Radix Polygalae 150g, Radix Polygoni Multiflori 150g, Herba Epimedii 150g, Rhizoma Dioscoreae 150g joins in the 3L water and decocts, medicinal residues add same water gaging again and decoct 2 times, the each decoction 1 hour, merge 3 times decocting liquid, filter, be condensed into the thick paste of relative density 1.25 (60 ℃), after 50 ℃ of dryings, be ground into 120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.
Embodiment 2
Take by weighing Ganoderma 100g, Radix Angelicae Sinensis 100g, Radix Et Caulis Acanthopanacis Senticosi 100g, Semen Ziziphi Spinosae 300g, Fructus Lycii 100g, Radix Polygalae 100g, Radix Polygoni Multiflori 100g, Herba Epimedii 100g, Rhizoma Dioscoreae 150g joins in the 3L water and decocts, medicinal residues add same water gaging again and decoct 2 times, the each decoction 1 hour, merge 3 times decocting liquid, filter, be condensed into the thick paste of relative density 1.3 (60 ℃), after 60 ℃ of dryings, be ground into 120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.
Embodiment 3
Take by weighing Ganoderma 120g, Radix Angelicae Sinensis 120g, Radix Et Caulis Acanthopanacis Senticosi 120g, Semen Ziziphi Spinosae 250g, Fructus Lycii 120g, Radix Polygalae 120g, Radix Polygoni Multiflori 120g, Herba Epimedii 120g, Rhizoma Dioscoreae 250g joins in the 3L water and decocts, medicinal residues add same water gaging again and decoct 2 times, the each decoction 0.5 hour, merge 3 times decocting liquid, filter, be condensed into the thick paste of relative density 1.3 (50 ℃), after 50 ℃ of dryings, be ground into 100 purpose medicated powder, in incapsulating, sterilization makes the capsule product.
Claims (3)
1, a kind ofly being used for the treatment of neurasthenic medicine, is to be that crude drug prepares by following parts by weight of traditional Chinese medicines:
Ganoderma 5～20 Radix Angelicae Sinensis 5～20
Radix Et Caulis Acanthopanacis Senticosi 5～20 Semen Ziziphi Spinosaes 20～40
Fructus Lycii 5～20 Radix Polygalaes 5～20
Radix Polygoni Multiflori 5～20 Herba Epimedii 5～20
Rhizoma Dioscoreae 10～30.
2, according to claim 1ly be used for the treatment of neurasthenic medicine, it is characterized in that described medicine is a capsule.
3, the described preparation method that is used for the treatment of neurasthenic medicine of claim 2, be according to described parts by weight mix homogeneously with above-mentioned various medicines, decoct with water 3 times, each 0.5～1 hour, merge 3 times decocting liquid, filter, be condensed into 60 ℃ of relative densities and be 1.25～1.3 thick paste, after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, sterilization makes the capsule product in incapsulating.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100798730A CN101444583A (en) | 2008-11-18 | 2008-11-18 | Medicament for curing neurasthenia |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101919962B (en) * | 2009-06-10 | 2012-01-25 | 河北以岭医药研究院有限公司 | Medicine for curing insomnia and preparation method thereof |
| CN103239607A (en) * | 2013-05-27 | 2013-08-14 | 郑爱惜 | Chinese medicine preparation for treating amnesia caused by neurasthenia |
| CN103621893A (en) * | 2013-11-26 | 2014-03-12 | 青岛嘉瑞生物技术有限公司 | Health-care noodle for refreshing, tonifying brain, and improving learning and memory capacities and production method thereof |
| CN108670894A (en) * | 2018-06-12 | 2018-10-19 | 漳州龙文琪睿生物科技有限公司 | A kind of preparation method of safety-type tranquilizing the mind perfume |
-
2008
- 2008-11-18 CN CNA2008100798730A patent/CN101444583A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101919962B (en) * | 2009-06-10 | 2012-01-25 | 河北以岭医药研究院有限公司 | Medicine for curing insomnia and preparation method thereof |
| CN103239607A (en) * | 2013-05-27 | 2013-08-14 | 郑爱惜 | Chinese medicine preparation for treating amnesia caused by neurasthenia |
| CN103621893A (en) * | 2013-11-26 | 2014-03-12 | 青岛嘉瑞生物技术有限公司 | Health-care noodle for refreshing, tonifying brain, and improving learning and memory capacities and production method thereof |
| CN108670894A (en) * | 2018-06-12 | 2018-10-19 | 漳州龙文琪睿生物科技有限公司 | A kind of preparation method of safety-type tranquilizing the mind perfume |
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Open date: 20090603 |