CN1175893C - Medicine for treating child multiacting disease and its preparation method - Google Patents
Medicine for treating child multiacting disease and its preparation method Download PDFInfo
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- CN1175893C CN1175893C CNB031182550A CN03118255A CN1175893C CN 1175893 C CN1175893 C CN 1175893C CN B031182550 A CNB031182550 A CN B031182550A CN 03118255 A CN03118255 A CN 03118255A CN 1175893 C CN1175893 C CN 1175893C
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- hyperkinetic syndrome
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Abstract
The present invention discloses a medicine for treating childhood hyperkinetic syndrome, which is prepared from ginseng, astragalus root, grassleaf sweetflag rhizome, thinleaf milkwort root, tuckahoe and liquorice root as raw materials. According to different characteristics of each Chinese medicine, the raw materials are proportionally prepared by pulverization, infiltration, decoction, drying and filling. The present invention is a medicine for treating childhood hyperkinetic syndrome, which is prepared from natural Chinese medicinal materials and has the advantages of good and obvious therapeutic efficacy, no toxic and side effect, simple preparation, low cost and unique preparing method.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of childhood hyperkinetic syndrome, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
Background technology
Hyperkinetic syndrome; it is one of modal nervous system disease of Childhood; refer to the normal or approaching normal child of intelligence; cause by multiple factor; show the disproportionate hyperkinesia of its level of intelligence clinically; attention laxes, emotional instability and wilful impulsion, and learning difficulty is in various degree arranged, the time a kind of comprehensive obstacle of central nervous system function slightly misaligned (sensory perception, speech, memory notion form, motor control) arranged.According to investigations, sickness rate is about 5%, and in this ratio, the patient of hyperkinetic syndrome suffers from about 20,000,000 in China.Hyperkinetic syndrome patient nearly 100,000,000 is estimated in the whole world.
Doctor trained in Western medicine is complicated to the pathogeny of childhood hyperkinetic syndrome, and clarification fully as yet so far current consistently thinks that hyperkinetic syndrome is that multiple factor causes, and 1, the brain frontal cortex hypoevolutism; 2, heredity; 3, the neurotransmitter deficiency in the neurocyte synaptic space; 4, Xiao Jiliang lead poisoning; 5, nervous etc.; The traditional Chinese medical science thinks that the etiology and pathogenesis of childhood hyperkinetic syndrome is an imbalance of YIN and YANG, and the visceral dysfunction theory also has the Fructus Alpiniae Oxyphyllae therapy of allaying excitement, and the therapy of intending nourishing the kidney for subduing the hyperactivity of liver-YANG is also arranged, and therapy that endogenous wind stopping composes oneself etc. is also arranged.The clinical treatment that is used for hyperkinetic syndrome at present all is a Western medicine, and its Western medicine kind has amfetamine, methylphenidate, pemoline, and there is the defective of two aspects in these medicines, and one is that side effect is big, and the clinicist is difficult to grasp, and the patient is difficult to accept; Two is that these medicines are the medicine that belongs to the psychosis aspect a bit, there is clear and definite regulation in country in management, the Bureau of Drugs Supervision of hospital that must will have anesthesia, psychotropic substances could ratify and can buy, therefore, County Hospital and following hospital at county level all can not buy, and that has just had no way of talking the treatment hyperkinetic syndrome, therefore, the hyperkinetic syndrome of China's treatment at present also is a blind area, can't carry out.
Summary of the invention
Technical problem to be solved by this invention provide a kind of with natural Chinese medicines material preparation, therapeutic effect is good, without any toxic and side effects and prepare the medicine of treatment childhood hyperkinetic syndrome simple, with low cost.
Another technical problem to be solved by this invention provides the preparation method of this medicine.
The mechanism that the technical solution used in the present invention is based on childhood hyperkinetic syndrome is by the understanding due to deficiency of both QI and blood and the deficiency of both the heart and spleen, from motherland's medicine treasure-house, filter out strengthening by means of tonics, help gas to strengthen muscle, spleen reinforcing nourishing the stomach, the body resistance strengthening and constitution consolidating, the homologous natural edible plant amedica of medicated diet, by the theory of Chinese medical science prescription, make its performance QI invigorating enrich blood, improve patient's body constitution, the effect of treatment childhood hyperkinetic syndrome.
Medicine of the present invention is prepared by following component: (consumption is 1000 meters of preparation)
Radix Ginseng 295～325g Radix Astragali 450～550g
Rhizoma Acori Graminei 100～150g Radix Polygalae 100～150g
Poria 700～800g Radix Glycyrrhizae 32～45g
The preferred weight of medicine of the present invention (part) ratio range is:
Radix Ginseng 300～318g Radix Astragali 480～520g
Rhizoma Acori Graminei 110～135g Radix Polygalae 110～135g
Poria 720～780g Radix Glycyrrhizae 35～40g
The optimum weight of medicine of the present invention (part) proportioning is:
Radix Ginseng 312.5g Radix Astragali 500g
Rhizoma Acori Graminei 125g Radix Polygalae 125g
Poria 750g Radix Glycyrrhizae 37.5g
Childhood hyperkinetic syndrome claims hyperkinetic syndrome, child's minimal brain dysfunction (MBD) again, belongs to that the traditional Chinese medical science " is become deaf ", category such as " forgetful ", " wind card ", " agitation "." element is asked the vital QI of the body connecting with natural QI opinion " said: " YIN and YANG in a relative equilibrium, life activities being normally maintained." heart storing spirit, idea stored in the spleen, liver storing soul, kidney storing will.Children's's life is flourishing, and blastoprolepsis so is the body of " the young sun of young the moon ", and heart kidney essense gas does not fill, the spleen tending to insufficiency usually, the liver being liable to excess.If a little less than the natural endowment element, or the day after tomorrow intemperance of taking food, take good care of not normally, involve internal organs so that the heart, spleen deficiency, imbalance between YIN and YANG.Then mind imbalance of heart spleen vital essence deficiency, and god is not peaceful, the soul uneasiness, it is inconsiderate to anticipate, and will is not hard, clinically sees that then attention laxes, and learning difficulty is said all diseases.Cloudy essence is not filled, and yang-energy is prosperous partially, then sees hyperactivity, the wilful all diseases of getting excited.Deficiency of spleen-QI and stomach-QI, fortuneization mistake department, no resource of generating and transforming QI and blood, the body of can not supplementing nutrition, then visible anorexia loose stool, diseases such as emaciation and sallow complexion, it controls suitable invigorating the heart and spleen, allays excitement and keeps will.Chinese patent medicine of the present invention adopts " water, induce " therapy, just a small amount of intermittent administration method; Radix Ginseng among the present invention, sweet, the little hardship of nature and flavor, flat; Return spleen, lung, heart channel; The function strongly invigorating primordial QI, supplementing blood and promoting the production of body fluid, the spleen invigorating of nourishing heart, mind tranquilizing, monarch drug.The Radix Astragali, nature and flavor are sweet, tepor; Return spleen, lung meridian; The function invigorating the spleen and benefiting QI, strengthening superficial resistance to stop perspiration.Poria, nature and flavor are sweet, light, and are flat; GUIXIN, spleen, lung, kidney, stomach warp; Function spleen invigorating invigorating middle warmer, mind tranquilizing and the heart calming.The auxiliary monarch drug of two medicines is to strengthen invigorating the heart and spleen, and the power of tranquilizing the mind is all ministerial drug.Rhizoma Acori Graminei, Radix Polygalae assistant help the happy key of monarch-minister drug, mind calming god in the side, are adjuvant drug.The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, and the usefulness that strengthens the spleen and stomach is arranged, so make it medicine for helping.All medicines and closing are played the sedate that nourishes heart altogether, and the merit of invigorating the spleen and benefiting QI is coincide with the etiology and pathogenesis of childhood hyperkinetic syndrome deficiency of both the heart and spleen, when proving effective.
Above-mentioned each component is made medicine production method of the present invention is:
1, medical material pretreatment: Radix Ginseng, the Radix Astragali, Rhizoma Acori Graminei, Radix Polygalae, Poria, Radix Glycyrrhizae are chosen respectively, clean oven dry, wherein the Radix Ginseng powder directly is used as medicine after being broken into fine powder;
2, soak into, decoct: the Radix Astragali, Rhizoma Acori Graminei, Radix Polygalae, Poria, Radix Glycyrrhizae are added 10 times of amounts of water, soak into after 20 minutes, be heated to and boil, keep little and boiled 2 hours, collect medicinal liquid; Above-mentioned medical material is added 8 times of water gagings for the second time, decocted 2 hours, merge medicinal liquid twice, filter, filtrate is concentrated into the thick paste of relative density 1.3～1.35 (60～65 ℃), puts cold, stand-by;
3, drying:, pulverize with Radix Ginseng medicated powder and thick paste drying;
4, fill: the medicated powder fill in capsule, is adorned 0.42g for every.
In order to show the therapeutic effect of medicine of the present invention to childhood hyperkinetic syndrome, the present invention has carried out following clinical experiment.
The childhood hyperkinetic syndrome diagnostic criteria was put research association in order 1986 with reference to All-China Association of Traditional Chinese Medicine is theoretical " academic conference of national childhood hyperkinetic syndrome special topic " formulation behavior rating scale and diagnostic criteria (Leng Fangnan, etc.The childhood hyperkinetic syndrome clinical therapeutics.Beijing: Chinese Medicine science and technology publishing house.1990，23)。
The diagnostic criteria of deficiency of both the heart and spleen disease is with reference to " the dialectical heart temper of child's Cerebral function slight maladjustment clinical diagnosis blood deficiency, empty sun float " (chief editor such as Chen Guiyan.Practical combination of Chinese and Western medicine diagnoses and treatment.Beijing: the scientific and technological publishing house of Chinese Chinese medicine, 1998,1135).
Observe 80 examples altogether, each 40 example of wherein treatment group and matched group.
Treatment group: medicine of the present invention.7～10 years old, one time 4; 11～14 years old, one time 5.Homogeneous day once, 7 o'clock of morning warm water delivery service.Matched group: methylphenidate.One time 10, once-a-day, 7 o'clock of morning warm water delivery service.Two groups is a course of treatment with 4 weeks all, and in the observation process, the experimenter must not take with observed disease and be the Chinese and western drugs of principal indication and adopt other treatment method at above-mentioned disease.
This Drug therapy of table 1 childhood hyperkinetic syndrome curative effect
| The example number | Recovery from illness | Produce effects | Effectively | Invalid | Total produce effects (%) | Total effectively (%) | |
| The treatment group | 40 | 3 | 23 | 12 | 2 | 26(65.0) | 38(95.0) |
| Matched group | 38 | 2 | 22 | 12 | 2 | 24(63.2) | 34(94.7) |
Treatment group and matched group be (Ridit check) relatively: P＞0.05
Evaluation result before and after the treatment of table 2 observation case behavior rating scale total points (X ± SD)
| The example number | Before the treatment | After the treatment | Difference before and after the treatment | |
| The treatment group | 40 | 29.4±8.3 | 11.6±9.1 | 17.8±6.9 |
| Matched group | 38 | 28.7±7.2 | 12.3±10.3 | 15.4±7.7 |
1. each is organized and compares (t check) in the group of treatment front and back: treatment group, P＜0.01; Matched group, P＜0.01.2. compare between difference before and after treatment group and the treatment of control group (t check): P＞0.05
This medicine of table 3 is laxed the doing well,improving situation to childhood hyperkinetic syndrome patient active attention power
| The example number | Produce effects | Effectively | Invalid | Produce effects (%) | Total effectively (%) | |
| The treatment group | 40 | 26 | 13 | 1 | 26(65.0) | 39(97.5) |
| Matched group | 38 | 24 | 12 | 2 | 24(6 3.2) | 36(94.7) |
Treatment group and matched group be (Ridit check) relatively: P＞0.05
This medicine of table 4 is to childhood hyperkinetic syndrome patient hyperactivity doing well,improving situation
| The example number | Produce effects | Effectively | Invalid | Produce effects (%) | Total effectively (%) | |
| The treatment group | 37 | 24 | 11 | 2 | 24(64.9) | 35(94.6) |
| Matched group | 35 | 23 | 11 | 1 | 2 3(65.7) | 34(97.1) |
Treatment group and matched group be (Ridit check) relatively: P＞0.05
This medicine of table 5 is to childhood hyperkinetic syndrome patient learning difficulty doing well,improving situation
| The example number | Produce effects | Effectively | Invalid | Produce effects (%) | Total effectively (%) | |
| The treatment group | 36 | 20 | 2 | 4 | 20(5 5.6) | 32(88.9) |
| Matched group | 35 | 19 | 3 | 2 | 19(54.3) | 32(91.4) |
Treatment group and matched group be (Ridit check) relatively: P＞0.05
As can be known from Table 1, total obvious effective rate that the present invention treats childhood hyperkinetic syndrome is 90.0%, and total effective rate is 95.5%, compares there was no significant difference (P＞0.05) with the matched group curative effect, illustrates that two curative effect of medication are suitable.
As can be known from Table 2, two groups of behavior rating scale total points all have the decline of utmost point significance meaning after the medication, and behavior rating scale decline diversity ratios are than not statistically significant (P＞0.05) before and after two groups of treatments.
From table 3～5 explanation, treatment group and matched group have in various degree the effect of improving to the main clinic symptoms of childhood hyperkinetic syndrome, and the former is similar to the latter in effect.
Treatment group case is not found obvious adverse reaction, and have a blood test before and after the treatment, urine, stool routine examination and electrocardiogram, ALT, Cr do not note abnormalities variation, it is safer pointing out medicine of the present invention.And matched group has 4 example appearance n or V in various degree, inappetence appears in 4 examples, and slight headache, dizziness appear in 2 examples, and untoward reaction such as xerostomia appear in 2 examples, with bibliographical information is consistent, illustrates that from another angle medicine of the present invention has certain advantage aspect the drug safety simultaneously.
Description of drawings
Accompanying drawing is technological process of production figure of the present invention.
The specific embodiment
Take by weighing raw material by following proportioning:
Radix Ginseng 312.5g Radix Astragali 500g
Rhizoma Acori Graminei 125g Radix Polygalae 125g
Poria 750g Radix Glycyrrhizae 37.5g
Referring to accompanying drawing, production method is as follows: Radix Ginseng is dried and crushed into fine powder, and is standby; All the other five kinds of Chinese medicine add 10 times of water gagings and soak after about 20 minutes and to decoct 2 hours, filter, adding 8 times of water gagings again decocted 2 hours with method, collecting decoction filters, and filtrate is concentrated into the thick paste that relative density is 1.3～1.35 (60～65 ℃), with thick paste and Radix Ginseng powder's mixing drying, be ground into fine powder, incapsulate, make 1000.
Claims (6)
1, a kind of medicine for the treatment of childhood hyperkinetic syndrome is characterized in that it is to make 1000 medicaments of making of meter materials of weight proportions by following
Radix Ginseng 295～325g Radix Astragali 450～550g
Rhizoma Acori Graminei 100～150g Radix Polygalae 100～150g
Poria 700～800g Radix Glycyrrhizae 32～45g
2, a kind of medicine for the treatment of childhood hyperkinetic syndrome according to claim 1, it is characterized in that each raw material of described medicament make 1000 the meter weight proportions be
Radix Ginseng 300～318g Radix Astragali 480～520g
Rhizoma Acori Graminei 110～135g Radix Polygalae 110～135g
Poria 720～780g Radix Glycyrrhizae 35～40g
3, a kind of medicine for the treatment of childhood hyperkinetic syndrome according to claim 1, it is characterized in that each raw material of described medicament make 1000 the meter weight proportions be
Radix Ginseng 312.5g Radix Astragali 500g
Rhizoma Acori Graminei 125g Radix Polygalae 125g
Poria 750g Radix Glycyrrhizae 37.5g
4,, it is characterized in that described medicament is the above a dosage form of any pharmaceutics according to claim 1,2 or 3 described a kind of medicines for the treatment of childhood hyperkinetic syndrome.
5, a kind of medicine for the treatment of childhood hyperkinetic syndrome according to claim 4 is characterized in that described medicament is a capsule.
6, a kind of method for preparing the medicine of claim 1, it is characterized in that: Radix Ginseng is dried and crushed into fine powder, and is standby; All the other five kinds of Chinese medicine add 10 times of water gagings and soak after about 20 minutes and to decoct 2 hours, filter, adding 8 times of water gagings again decocted 2 hours with method, collecting decoction, filter, being concentrated into relative density 60～65 ℃ of following filtrates is 1.3～1.35 thick paste, with thick paste and Radix Ginseng powder's mixing drying, be ground into fine powder, make capsule.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100344312C (en) * | 2004-11-10 | 2007-10-24 | 赵振伟 | Prepn process of granule for treating children's hyperkinesia and its quality control method |
| CN101129649B (en) * | 2007-08-31 | 2010-05-26 | 浙江大学 | Traditional Chinese medicine compound formulation preparation method and uses |
| CN102205032B (en) * | 2011-05-31 | 2012-07-25 | 山东省农业科学院农产品研究所 | Golden mushroom oral liquid for treating hyperactivity disease |
| CN102319355B (en) * | 2011-10-15 | 2013-04-03 | 尹振中 | Chinese medicinal formula for treating hyperactivity and preparation method for pills thereof |
| CN104524245B (en) * | 2014-12-28 | 2017-08-01 | 重庆第二师范学院 | Chinese medicine composition and its preparation for treating children ADHD |
| CN109620932A (en) * | 2017-10-09 | 2019-04-16 | 范国华 | A kind of Chinese traditional treatment new method of children's hyperkinetic syndrome |
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