CN105796782B - A kind of Chinese medicine composition for preventing and/or treating Stein-Leventhal syndrome and its preparation method and application - Google Patents
A kind of Chinese medicine composition for preventing and/or treating Stein-Leventhal syndrome and its preparation method and application Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The present invention relates to a kind of timely preparation methods of Chinese medicine composition and purposes prevented and/or treat Stein-Leventhal syndrome, it is adhered to based on invigorating kidney, promoting blood circulation, it is aided with the therapy of soothing the liver resolving sputum, radix bupleuri, Semen Cuscutae, tortoise-shell glue, Herba Cistanches, safflower, cuttlebone, dried human placenta, frankincense, honey-fried licorice root efficient combination, effect with significant prevention and/or treatment Stein-Leventhal syndrome, can regulating menstruation and assisting pregnancy, tocolysis help and educate.
Description
Technical field
The invention belongs to the field of Chinese medicines, are specifically related to a kind of Chinese medicine group prevented and/or treat Stein-Leventhal syndrome
Close object and its preparation method and application.
Background technology
Stein-Leventhal syndrome (polyeystie ovary syndrome, PCOS), also known as Stein-leventhal are comprehensive
Simulator sickness is a kind of reproductive dysfunction and abnormal carbohydrate metabolism and the chronic endocrine disturbance syndrome deposited, by more inherent causes, more
The disorder of Hypothalamus-Pituitary-Ovaries functional shaft caused by gene and multi-environment factor, menstrual disorder (oligomenorrhea closes hair),
What chronic anovulation, infertile, insulin resistance, hyperinsulinemia, hyperandrogenism and ovary polycystic change were characterized
Different substantiality disease, incidence has more than 5% in the women of child-bearing age.
Doctor trained in Western medicine is for point treated mostly promoting ovulation drug to be used to increase follicular stimulating hormone of Stein-Leventhal syndrome at present
It secretes, promotes the development of ovarian follicle, blood androgen levels are reduced using antiandrogen drug, lutropin is reduced using contraceptive
(LH) it is horizontal, to adjust the menstrual cycle, using gonadotropin releasing hormone drug, the synthesis of androgen is reduced, thickens endometrium,
So as to be conducive to implantation, using Remedies for diabetes, such as melbine, improve glycometabolism etc..
In traditional Chinese medicine and there is no with the accurate corresponding disease name of Stein-Leventhal syndrome, according to Stein-Leventhal syndrome
Clinical signs, should in traditional Chinese medicine " amenorrhoea ", " menstrual disorder ", " infertile " it is corresponding, for this sick interpretation of the cause, onset and process of an illness, in
Medicine thinks it, and with kidney,spleen,liver, the heart etc., functional disturbances and phlegm wet, blood stasis are in close relations, and the specific interpretation of the cause, onset and process of an illness includes kidney deficiency, phlegm wet, blood
The stasis of blood, yin deficiency, the deficiency of yang, deficiency of vital energy etc..
The traditional Chinese medical science thinks kidney storing essence, main growth, development and reproduction, is the congenital foundation, essence in kidney be divided into kidney yang and kidney yin it
Point, the necessary requirement that kidney yang is normally discharged for ovum has the benefits of promoting, is warm, if kidney deficiency, uterus if essence loses blood less
It cannot effectively nourish, so as to cause infrequent menstruation or amenorrhoea, infertile, the stasis of blood is caused due to void, ovum be made to be difficult to discharge, ovary increases
Greatly, it can be seen that, one of kidney deficiency or the basic reason for ovulation failure.Traditional Chinese medicine is for the therapy of Stein-Leventhal syndrome at present
Including：Invigorating kidney, promoting blood circulation qi-promoting method, kidney tonifying is soothing the liver Circulation Resolving Phlegm adjust kidney clearing lung-heat method, change turbid disintoxication, warm kidney Circulation Resolving Phlegm etc., thus
It can be seen that the importance that kidney is treated for Stein-Leventhal syndrome.What the traditional Chinese medical science was also known as " The liver and the kidney have a common source " refers to that " woman is with liver
To be congenital " say, liver storing blood, liver blood is mutually grown with kidney essense, collectively forms the source of Follicular growth, and by liver, master dredges
The work(let out, can fluent punching appoint, the promoting flow of qi and blood is conducive to unimpeded and ovulate on time through row.It is supported if kidney deficiency liver arteries and veins loses, hepatic depression
Knot, catharsis is not normal, phlegm wet, stagnation of blood stasis, and amenorrhoea, ovarian follicle is caused to be difficult to increase and smoothly discharge, it is difficult into pregnant and cause infertile.
Therefore, this disease also has substantial connection with liver catharsis function.
At present it is existing treatment Stein-Leventhal syndrome treatment Chinese medicine include open palace ball, by the tuber of pinellia processed, rhizoma atractylodis, rhizoma cyperi,
The drugs such as Poria cocos, Divine Comedy, dried orange peel, Rhizoma Chuanxiong form；The female ball of benefit, by grass-leaved sweetflag, rhizoma pinellinae praeparata, Divine Comedy, Poria cocos, Divine Comedy, Poria cocos, old
Skin, Semen Cuscutae, HERBA EPIMEDII, the fruit of Chinese wolfberry, motherwort, Herba Lycopi, cattail pollen, Caulis Spatholobi, rhizoma cyperi etc.；Ginseng and astragalus combination, by Radix Astragali,
Radix Codonopsis, radix bupleuri, Radix Glycyrrhizae, Rhizoma Atractylodis Macrocephalae, cimicifugae foetidae, Poria cocos, dried orange peel, the tuber of pinellia, Radix Angelicae Sinensis are made；Longdan Xiegan Tang：By Radix Angelicae Sinensis, radix rehmanniae recen, bavin
Recklessly, felwort, mountain Cape jasmine, radix scutellariae, akebi, rhizoma alismatis, Chinese herbaceous peony etc. are made.
After for Stein-Leventhal syndrome current treatment status fully investigate to traditional Chinese medicine, present inventor is according to more
The interpretation of the cause, onset and process of an illness of capsule Ovary Syndrome kidney deficiency, phlegm wet, blood stasis, yin deficiency, the deficiency of yang, the deficiency of vital energy etc. is combed, drafted using invigorating kidney, promoting blood circulation as
It is main, it is aided with the therapy of soothing the liver resolving sputum, and a kind of Chinese medicine composition of new treatment Stein-Leventhal syndrome is obtained, through testing
Card has significant therapeutic effect, prevention and/or treatment available for Stein-Leventhal syndrome.
The content of the invention
The present invention provides a kind of Chinese medicine composition prevented and/or treat Stein-Leventhal syndrome, by radix bupleuri 8-10
Part, 5-8 parts of Semen Cuscutae, 5-8 parts of tortoise-shell glue, 5-8 parts of Herba Cistanches, 3-5 parts of safflower, 3-5 parts of cuttlebone, 1-3 parts of dried human placenta, breast
1-3 parts fragrant, 1-3 parts of compositions of honey-fried licorice root.
Preferred prevention and/or the Chinese medicine composition for the treatment of Stein-Leventhal syndrome, by 10 parts of radix bupleuri, 8 parts of Semen Cuscutae,
3 parts of 6 parts of tortoise-shell glue, 6 parts of Herba Cistanches, 5 parts of safflower, 5 parts of cuttlebone, 2 parts of dried human placenta, 2 parts of frankincense, honey-fried licorice root compositions.
In another aspect, the invention further relates to above-mentioned Chinese medicine compositions to prepare prevention and/or treatment Stein-Leventhal syndrome
Drug in purposes.
Further the present invention also provides a kind of systems for the Chinese medicine composition for preventing and/or treating Stein-Leventhal syndrome
Preparation Method comprises the following steps：
(1) crush：Tortoise-shell glue, Herba Cistanches, dried human placenta, frankincense are crushed to 80-100 mesh, obtain mixed-powder one, radix bupleuri, Tu
Silk, safflower, cuttlebone, honey-fried licorice root are crushed to 20-50 mesh, obtain mixed-powder two；
(2) extract：The purified water that mixed-powder two adds in 8-15 times of its weight decocts 1-2 times, and mixed extract is obtained and slightly carried
Object；
(3) concentrate：Relative density is the condensed cream of 1.03-1.06 when crude extract is dried under vacuum to room temperature；
(4) stirred evenly after condensed cream addition mixed-powder one, crushed after being dried is to get present invention prevention and/or prevention
The Chinese medicine composition of Stein-Leventhal syndrome.
In bulk pharmaceutical chemicals used in the present invention：
Radix bupleuri：In Return liver, courage, lung channel and inducing diaphoresis, soothing liver-qi stagnation, yang invigorating, preventing malaria of bringing down a fever, for cat fever, cold
Heat contact, distending pain in the chest and hypochondrium, irregular menstruation, the prolapse of uterus, rectal prolapse etc.；
Semen Cuscutae：Kidney,liver,spleen is returned to pass through, nourishing liver and kidney, astringent sperm contracting urine, tocolysis, improving eyesight, antidiarrheal, for lumbago due to the kidney deficiency, sun
Impotence seminal emission, frequent micturition, uterus cold infertile, the dark loose stool of mesh etc.；
Tortoise-shell glue：Return lung, liver and kidney channel, nourishing and suppressing Yang, replenishing kidney and strengthening bone are tonified the blood and arrest bleeding, for hectic fever due to yin caused by the deficiency of the kidney yin
Hectic fever, night sweat, dysphoria with smothery sensation palpitation with fear, lumbago due to the kidney deficiency, flaccidity of feet and knees；
Herba Cistanches：Return kidney, large intestine channel, kidney-replenishing, ease constipation road improve immunity, anti-aging, improve impotence and premature ejaculation, is anti-tired
Labor, protection liver, protection cardiovascular and cerebrovascular, runchang detoxification；
Safflower：Converge to heart and liver channels, dysmenorrhoea promoting blood circulation and removing blood stasis, removing pattogenic heat from the blood and toxic material from the body, for Amenorrhea, postpartum stasis, febrile virulent maculae, sorrow
Strongly fragrant ruffian is bored, palpitation with fear is gone mad；
Cuttlebone：Returns spleen, kidney channel, for hematemesis and epistaxis, blood leakage have blood in stool, emission and spermatorrhea, leukorrhea with reddish discharge, stomachache acid regurgitation etc.；
Dried human placenta：Return lung, the heart, kidney channel, tonifying kidney and benefiting sperm, nourishing qi and blood, for deficient, thin thin, hemoptysis asthma, the hot hectic fever due to yin of labor
Deng；
Frankincense：The thoughts of returning home, liver, the spleen channel, promoting qi circulation and relieving pain, detumescence and promoting granulation, for chest impediment and cardialgia, gastral cavity pain, dysmenorrhoea Amenorrhea, production
Stasis blocking, abdominal mass abdominal pain, arthralgia pain due to rheumatism, traumatic injury etc. afterwards；
Honey-fried licorice root：The thoughts of returning home, lung, spleen, stomach and middle emergency, moistening lung, removing toxic substances, coordinating the drug actions of a prescription, for it is weakness of the spleen and the stomach, burnout is weary
Power etc..
Beneficial effects of the present invention：
The present invention is adhered to based on invigorating kidney, promoting blood circulation, the therapy supplemented by soothing the liver resolving sputum, by radix bupleuri, Semen Cuscutae, tortoise-shell glue,
Herba Cistanches, safflower, cuttlebone, dried human placenta, the efficient combination of frankincense and honey-fried licorice root monarch, have significant prevention and/
Or the effect for the treatment of Stein-Leventhal syndrome, can regulating menstruation and assisting pregnancy, tocolysis help and educate.
Specific embodiment
Following embodiment is intended to illustrate invention rather than the further restriction of the present invention, and the present invention can be by the content of the invention
The either type is implemented.
Embodiment 1：A kind of Chinese medicine composition prevented and/or treat Stein-Leventhal syndrome
It is by 10 parts of radix bupleuri, 8 parts of Semen Cuscutae, 6 parts of tortoise-shell glue, 6 parts of Herba Cistanches, 5 parts of safflower, 5 parts of cuttlebone, dried human placenta
2 parts, 2 parts of frankincense, 3 parts of honey-fried licorice root composition, its preparation method is as follows：
(1) crush：Tortoise-shell glue, Herba Cistanches, dried human placenta, frankincense are crushed to 100 mesh, obtain mixed-powder one, radix bupleuri, Tu thread
Son, safflower, cuttlebone, honey-fried licorice root are crushed to 40 mesh, obtain mixed-powder two；
(2) extract：The purified water that mixed-powder two adds in 10 times of its weight decocts 2 times, and mixed extract obtains crude extract；
(3) concentrate：Relative density is the condensed cream of 1.03-1.06 when crude extract is dried under vacuum to room temperature；
(4) stirred evenly after condensed cream addition mixed-powder one, crushed after being dried is more up to present invention prevention and/or prevention
The Chinese medicine composition of capsule Ovary Syndrome.
Embodiment 2：A kind of Chinese medicine composition prevented and/or treat Stein-Leventhal syndrome
It is by radix bupleuri 8：Part, 5 parts of Semen Cuscutae, 5 parts of tortoise-shell glue, 5 parts of Herba Cistanches, 3 parts of safflower, 3 parts of cuttlebone, dried human placenta
1 part, 1 part of frankincense, 1 part of honey-fried licorice root composition, its preparation method is the same as embodiment 1.
Embodiment 3：A kind of Chinese medicine composition prevented and/or treat Stein-Leventhal syndrome
It is by 9 parts of radix bupleuri, 6 parts of Semen Cuscutae, 8 parts of tortoise-shell glue, 8 parts of Herba Cistanches, 4 parts of safflower, 4 parts of cuttlebone, dried human placenta 3
2 parts of part, 3 parts of frankincense, honey-fried licorice root compositions, its preparation method is the same as embodiment 1.
Effect example：Chinese medicine composition of the present invention is to the therapeutic effect of protona induction Polycystic ovary syndrome mouse
1st, experimental animal：
20 age in days SD female rats 60；
2nd, modeling method：
SD subcutaneous rats are embedded to the glue stick of the every levonorgestrel oxime containing 75mg, the skin 2 times a day since 27 ages in days
Lower injection 1.5IU HCG, co-injection 9d to 36 ages in days are randomly divided into three groups：Negative control group, 1 group of embodiment and palace ball group is opened,
Wherein 1 group of embodiment is 12.5g (raw medicinal herbs)/Kg/day with the dosage for opening palace ball group, and negative control group is equivalent pure water,
Oral gavage, gavage volume 20mL/Kg, once a day, after successive administration 30d, last gavage 60min, the neck that breaks is put to death, and measurement is big
Mouse weight, ovary weight and Ovarian Volume.
3rd, experimental result
Influence of 1 Chinese medicine composition of the present invention of table to Polycystic ovary syndrome mouse weight, ovary weight and Ovarian Volume
Note：Compared with negative control group, * P ＜ 0.05, * * P ＜ 0.01.
The experimental result of table 1 shows that the weight of negative control group rat substantially overweights 60 ages in days or so SD female averagely about
The weight of 250g is consistent with the fat characterization of Stein-Leventhal syndrome, and the ovary weight of SD rats substantially increases, and Ovarian Volume is shown
Increase is write, is also consistent with the characterization of Stein-Leventhal syndrome, shows Stein-Leventhal syndrome modeling success of the present invention, and is taken
There is certain mitigation to the increase of the weight of SD rats, ovary weight and Ovarian Volume after opening palace ball, it is shown that Qi Gong
Ball has certain therapeutic effect for Stein-Leventhal syndrome, takes rat after the Chinese medicine composition of the embodiment of the present invention 1
Weight gain is substantially suppressed, and weight is close to the average weight of 60 age in days normal female rats, ovary weight and ovary body
Product is also significantly less than negative control group, while is also significantly less than and opens palace ball group, shows the Chinese medicine composition of the present invention for more
The ovary weight of capsule Ovary Syndrome increases and Ovarian Volume increases with apparent inhibitory action, it is shown that the present composition
For the significant therapeutic effect of Stein-Leventhal syndrome, and its therapeutic effect is substantially better than and opens palace ball group, therefore, available for more
The prevention and/or treatment of capsule Ovary Syndrome.
Above example is only enumerating for the present invention, is prevented with Chinese medicine composition of the present invention and/or treatment polycystic ovary is comprehensive
The technical solution of simulator sickness and its relevant disease is each fallen in protection scope of the present invention.
Present invention merely illustrates some claimed specific embodiments, one of them or more skill
Recorded technical characteristic can be combined with arbitrary one or more technical solutions in art scheme, these are combined and obtain
Technical solution also in the application protection domain, technical solution is disclosed in the present invention just as obtained from these are combined
It is specifically recorded in content the same.
Claims (4)
1. a kind of Chinese medicine composition prevented and/or treat Stein-Leventhal syndrome, it is characterized in that being made of following bulk pharmaceutical chemicals：Bavin
8-10 parts of Hu, 5-8 parts of Semen Cuscutae, 5-8 parts of tortoise-shell glue, 5-8 parts of Herba Cistanches, 3-5 parts of safflower, 3-5 parts of cuttlebone, dried human placenta 1-
3 parts, 1-3 parts of frankincense, 1-3 parts of honey-fried licorice root.
2. prevention according to claim 1 and/or the Chinese medicine composition for the treatment of Stein-Leventhal syndrome, it is characterised in that by
Following bulk pharmaceutical chemicals are made：10 parts of radix bupleuri, 8 parts of Semen Cuscutae, 6 parts of tortoise-shell glue, 6 parts of Herba Cistanches, 5 parts of safflower, 5 parts of cuttlebone, purple
2 parts of river vehicle, 2 parts of frankincense, 3 parts of honey-fried licorice root.
3. the Chinese medicine composition described in claim 1 or 2 is in the drug for preparing prevention and/or treatment Stein-Leventhal syndrome
Purposes.
4. the preparation method of the Chinese medicine composition of prevention and/or the anti-Stein-Leventhal syndrome for the treatment of described in claim 1 or 2,
It is characterized by comprising following steps：
(1) crush：Tortoise-shell glue, Herba Cistanches, dried human placenta, frankincense are crushed to 80-100 mesh, obtain mixed-powder one, radix bupleuri, Semen Cuscutae,
Safflower, cuttlebone, honey-fried licorice root are crushed to 20-50 mesh, obtain mixed-powder two；
(2) extract：The purified water that mixed-powder two adds in 8-15 times of its weight decocts 1-2 times, and mixed extract obtains crude extract；
(3) concentrate：Relative density is the condensed cream of 1.03-1.06 when crude extract is dried under vacuum to room temperature；
(4) stirred evenly after condensed cream addition mixed-powder one, crushed after being dried is comprehensive to get preventing and/or preventing polycystic ovary
The Chinese medicine composition of simulator sickness.
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| CN114949060B (en) * | 2022-06-10 | 2023-04-07 | 广东罗浮山国药股份有限公司 | Composition for conditioning polycystic ovarian syndrome and preparation method thereof |
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| CN101167850A (en) * | 2007-10-20 | 2008-04-30 | 徐究竟 | Medicine for treating polycystic ovary syndrome and preparation technology thereof |
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| Title |
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| 补肾活血调周法治疗多囊卵巢综合征疗效观察;徐莲薇等;《上海中医药杂志》;20081210(第12期);第38页第1.5节、第39页右栏第2段 * |
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