CN105796782A - Traditional Chinese medicine composition for preventing and/or treating polycystic ovarian syndrome and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for preventing and/or treating polycystic ovarian syndrome and preparation method and application thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention relates to a traditional Chinese medicine composition for preventing and/or treating polycystic ovarian syndrome and a preparation method and an application thereof.The traditional Chinese medicine composition adheres to the method of treatment that the major function is nourishing kidney and promoting blood circulation, supplemented by smoothing liver and eliminating phlegm.Root of Chinese thorowax, seed of Chinese dodder, glue of tortoise plastron, desertliving cistanche, saffron crocus, cuttle-bone, human placenta, frankincense and honey-fried licorice root are combined effectively, thus the traditional Chinese medicine composition has remarkable effects of preventing and/or treating polycystic ovarian syndrome, and can be used for regulating menstruation, helping pregnancy and preventing miscarriage.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to Chinese medicine composition of a kind of prevention and/or treatment polycystic ovarian syndrome and its production and use.
Background technology
Polycystic ovarian syndrome (polyeystieovarysyndrome, PCOS), also known as Stein-leventhal syndrome, it is a kind of reproductive dysfunction and abnormal carbohydrate metabolism the chronic endocrine regulation syndrome deposited, by many inherited genetic factorss, the disorder of the hypothalamic-pituitary-ovarian functional shaft that polygenes and multi-environment factor cause, menoxenia (hypomenorrhea or close send out), chronic anovulation, infertile, insulin resistant, hyperinsulinemia, hyperandrogenism and ovary polycystic change are the different substantiality disease of feature, in the women of child-bearing age, sickness rate has more than 5%.
Current doctor trained in Western medicine is for the many secretions to use promoting ovulation drug to increase follicule-stimulating hormone (FSH) for the treatment of of polycystic ovarian syndrome, promote the growth of follicle, use androgen antagonist medicine to reduce blood androgen levels, use contraceptive to reduce lutropin (LH) level, to regulate menstrual cycle, use gonadotropin releasing hormone medicine, reduce androgenic synthesis, thicken endometrium, thus being conducive to implantation, use Remedies for diabetes, such as metformin, improve carbohydrate metabolism etc..
In Chinese medicine and be absent from the disease name accurately corresponding with polycystic ovarian syndrome, Clinical signs according to polycystic ovarian syndrome, it should be corresponding with " amenorrhea ", " menoxenia ", " infertile " in Chinese medicine, pathogenesis for this disease, Chinese medicine thinks that it is in close relations with phlegm-damp, blood stasis with the functional disorder such as kidney,spleen,liver, the heart, and concrete pathogenesis includes suffering from a deficiency of the kidney, phlegm-damp, blood stasis, yin deficiency, yang deficiency, the deficiency of vital energy etc..
The traditional Chinese medical science thinks kidney storing essence, and main growth, growth and reproduction, for the congenital foundation, essence in kidney be divided into kidney yang and kidney yin point, kidney yang is the necessary requirement that ovum is normally discharged, and has promotion, warm effect, if deficiency of kidney-YIN, damage of essence insufficiency of blood then uterus can not get effective nourishing, thus cause infrequent menstruation or amenorrhea, infertile, cause the stasis of blood because of empty, make ovum be difficult to discharge, ovary increases, as can be seen here, suffer from a deficiency of the kidney or for one of the basic reason of ovulation failure.Current Chinese medicine includes for the method for the treatment of of polycystic ovarian syndrome: invigorating kidney, promoting blood circulation qi-promoting method, the kidney invigorating is soothing the liver Circulation Resolving Phlegm, adjusts kidney lung heat clearing method, change turbid disintoxication, the kidney warming Circulation Resolving Phlegm etc., thus it is also seen that the importance treated for polycystic ovarian syndrome of kidney.The traditional Chinese medical science also have saying of touch upon " the woman is based on the liver " of " The liver and the kidney have a common source ", liver storing blood, and liver blood and kidney essense are grown mutually, collectively form the source of Follicular growth, by the merit of liver controlling conveyance and dispersion, can fluent punching appoint, promoting flow of QI and blood, is conducive to unimpeded through row and ovulates on time.If suffered from a deficiency of the kidney the liver pulse lose support, depression of liver-QI, catharsis is not normal, phlegm-damp, stagnation of blood stasis, and cause amenorrhea, follicle is difficult to increase and discharge smoothly, it is difficult to become pregnant and cause infertile.Therefore, primary disease and liver catharsis function also have substantial connection.
The Chinese medicine of current existing treatment polycystic ovarian syndrome treatment includes opening palace ball, is made up of medicines such as Rhizoma Pinelliae Preparata, Rhizoma Atractylodis, Rhizoma Cyperi, Poria, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, Rhizoma Chuanxiongs；The female ball of benefit, by Rhizoma Acori Graminei, Rhizoma Pinelliae Preparatum, Massa Medicata Fermentata, Poria, Massa Medicata Fermentata, Poria, Pericarpium Citri Reticulatae, Semen Cuscutae, Herba Epimedii, Fructus Lycii, Herba Leonuri, Herba Lycopi, Pollen Typhae, Caulis Spatholobi, Rhizoma Cyperi etc.；Ginseng and astragalus combination, is made up of the Radix Astragali, Radix Codonopsis, Radix Bupleuri, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Cimicifugae, Poria, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Radix Angelicae Sinensis；Decoction of Gentiana for Purging the Liver-fire: be made up of Radix Angelicae Sinensis, Radix Rehmanniae, Radix Bupleuri, Radix Gentianae, Fructus Gardeniae, Radix Scutellariae, Caulis Akebiae, Rhizoma Alismatis, Herba Plantaginis etc..
After Chinese medicine is carried out fully investigation for polycystic ovarian syndrome current treatment status, present inventor suffers from a deficiency of the kidney according to polycystic ovarian syndrome, the pathogenesis of phlegm-damp, blood stasis, yin deficiency, yang deficiency, the deficiency of vital energy etc. carries out combing, draft based on invigorating kidney, promoting blood circulation, it is aided with the soothing the liver method for the treatment of reduced phlegm, and obtain the Chinese medicine composition of a kind of new treatment polycystic ovarian syndrome, experiment proves that there is significant therapeutic effect, can be used for the prevention of polycystic ovarian syndrome and/or treatment.
Summary of the invention
The invention provides a kind of prevention and/or the Chinese medicine composition for the treatment of polycystic ovarian syndrome, it is made up of Radix Bupleuri 8-10 part, Semen Cuscutae 5-8 part, Colla Plastri Testudinis 5-8 part, Herba Cistanches 5-8 part, Stigma Croci 3-5 part, Endoconcha Sepiae 3-5 part, Placenta Hominis 1-3 part, Olibanum 1-3 part, Radix Glycyrrhizae Preparata 1-3 part.
The Chinese medicine composition of preferred prevention and/or treatment polycystic ovarian syndrome, it is made up of Radix Bupleuri 10 parts, Semen Cuscutae 8 parts, Colla Plastri Testudinis 6 parts, Herba Cistanches 6 parts, Stigma Croci 5 parts, Endoconcha Sepiae 5 parts, Placenta Hominis 2 parts, Olibanum 2 parts, Radix Glycyrrhizae Preparata 3 parts.
Another further aspect, the invention still further relates to above-mentioned Chinese medicine composition purposes in the medicine of preparation prevention and/or treatment polycystic ovarian syndrome.
The preparation method that further present invention also offers the Chinese medicine composition of a kind of prevention and/or treatment polycystic ovarian syndrome, it comprises the following steps:
(1) pulverize: Colla Plastri Testudinis, Herba Cistanches, Placenta Hominis, frankincense powder are broken to 80-100 order, obtain mixed-powder one, and Radix Bupleuri, Semen Cuscutae, Stigma Croci, Endoconcha Sepiae, Radix Glycyrrhizae Preparata are crushed to 20-50 order, obtain mixed-powder two；
(2) extracting: mixed-powder two adds its purified water of weight 8-15 times and decocts 1-2 time, mixed extract obtains crude extract；
(3) concentration: when crude extract vacuum drying is to room temperature, relative density is the condensed cream of 1.03-1.06；
(4) condensed cream stirs after adding mixed-powder one, crushed after being dried, obtains present invention prevention and/or the Chinese medicine composition of prevention polycystic ovarian syndrome.
In crude drug used in the present invention:
Radix Bupleuri: return liver, gallbladder, lung meridian, reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang, preventing the attack (or recurrence) of malaria of bringing down a fever, for cat fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis etc.；
Semen Cuscutae: return kidney,liver,spleen warp, nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal, for lumbago due to renal deficiency, impotence and seminal emission, frequent micturition, infertile, the dark loose stool of order of cold womb etc.；
Colla Plastri Testudinis: return lung, liver, kidney channel, nourishing YIN for suppressing the hyperactive YANG, replenishing kidney and strengthening bone, tonifying blood and arresting bleeding, the osteopyrexia and fever caused for deficiency of kidney yin, night sweat, dysphoria with smothery sensation palpitation with fear, lumbago due to renal deficiency, flaccidity of feet and knees；
Herba Cistanches: return kidney, large intestine channel, kidney-replenishing, intestine moistening road, improve immunity, defying age, improve impotence and premature ejaculation, resisting fatigue, the liver protecting, protection cardiovascular and cerebrovascular vessel, intestine moistening toxin expelling；
Stigma Croci: GUIXIN, Liver Channel, blood circulation promoting and blood stasis dispelling dysmenorrhea, removing pathogenic heat from blood and toxic substance from the body, palpitation with fear vexed for amenorrhea, postpartum stagnation, maculae caused by violent heat pathogen, melancholy painful abdominal mass is gone mad；
Endoconcha Sepiae: return spleen, kidney channel, have blood in stool for hematemesis and epistaxis, blood leakage, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation etc.；
Placenta Hominis: returning lung, the heart, kidney channel, the kidney invigorating and essence nourishing, benefiting QI and nourishing blood, for deficient, weakness and emaciation, hemoptysis asthma, consumptive fever hectic fever due to YIN-deficiency etc.；
Olibanum: GUIXIN, liver, spleen channel, promoting the circulation of QI to relieve pain, detumescence and promoting granulation, for obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, postpartum stagnation, lump in the abdomen stomachache, rheumatic arthralgia, traumatic injury etc.；
Radix Glycyrrhizae Preparata: GUIXIN, lung, spleen, stomach, and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription, for weakness of the spleen and stomach, fatigue and weakness etc..
Beneficial effects of the present invention:
The present invention acts on based on invigorating kidney, promoting blood circulation, reduce phlegm as auxiliary method for the treatment of with soothing the liver, efficient combination by Radix Bupleuri, Semen Cuscutae, Colla Plastri Testudinis, Herba Cistanches, Stigma Croci, Endoconcha Sepiae, Placenta Hominis, Olibanum and Radix Glycyrrhizae Preparata monarch, there is significant prevention and/or the effect for the treatment of polycystic ovarian syndrome, can regulating menstruation and assisting pregnancy, antiabortive helping educate.
Detailed description of the invention
Following example are intended to illustrate the present invention rather than the present invention further limits, and the present invention can implement by the either type described in summary of the invention.
Embodiment 1: the Chinese medicine composition of a kind of prevention and/or treatment polycystic ovarian syndrome
It is made up of Radix Bupleuri 10 parts, Semen Cuscutae 8 parts, Colla Plastri Testudinis 6 parts, Herba Cistanches 6 parts, Stigma Croci 5 parts, Endoconcha Sepiae 5 parts, Placenta Hominis 2 parts, Olibanum 2 parts, Radix Glycyrrhizae Preparata 3 parts, and its preparation method is as follows:
(1) pulverize: Colla Plastri Testudinis, Herba Cistanches, Placenta Hominis, frankincense powder are broken to 100 orders, obtain mixed-powder one, and Radix Bupleuri, Semen Cuscutae, Stigma Croci, Endoconcha Sepiae, Radix Glycyrrhizae Preparata are crushed to 40 orders, obtain mixed-powder two；
(2) extracting: mixed-powder two adds the purified water of its weight 10 times and decocts 2 times, mixed extract obtains crude extract；
(3) concentration: when crude extract vacuum drying is to room temperature, relative density is the condensed cream of 1.03-1.06；
(4) condensed cream stirs after adding mixed-powder one, and namely crushed after being dried obtains present invention prevention and/or the Chinese medicine composition of prevention polycystic ovarian syndrome.
Embodiment 2: the Chinese medicine composition of a kind of prevention and/or treatment polycystic ovarian syndrome
It is by Radix Bupleuri 8: part, Semen Cuscutae 5 parts, Colla Plastri Testudinis 5 parts, Herba Cistanches 5 parts, Stigma Croci 3 parts, Endoconcha Sepiae 3 parts, Placenta Hominis 1 part, Olibanum 1 part, Radix Glycyrrhizae Preparata 1 part form, and its preparation method is with embodiment 1.
Embodiment 3: the Chinese medicine composition of a kind of prevention and/or treatment polycystic ovarian syndrome
It is made up of Radix Bupleuri 9 parts, Semen Cuscutae 6 parts, Colla Plastri Testudinis 8 parts, Herba Cistanches 8 parts, Stigma Croci 4 parts, Endoconcha Sepiae 4 parts, Placenta Hominis 3 parts, Olibanum 3 parts, Radix Glycyrrhizae Preparata 2 parts, its preparation method is with embodiment 1.
Effect example: dihydrotestosterone is induced the therapeutic effect of Polycystic ovary syndrome mouse by Chinese medicine composition of the present invention
1, laboratory animal:
20 age in days SD female rats 60；
2, modeling method:
SD subcutaneous rat imbeds the every glue stick containing 75mg levonorgestrel oxime, 2 subcutaneous injection 1.5IUHCG every day are started from 27 ages in days, injection 9d to 36 age in days altogether, it is randomly divided into three groups: negative control group, embodiment 1 group and open palace ball group, wherein embodiment 1 group and to open the dosage of palace ball group be 12.5g (raw medicinal herbs)/Kg/day, negative control group is equivalent pure water, per os gavage, gavage volume 20mL/Kg, once a day, successive administration 30d, after last gavage 60min, disconnected neck is put to death, and measures rat body weight, ovary weight and Ovarian Volume.
3, experimental result
The impact on Polycystic ovary syndrome mouse body weight, ovary weight and Ovarian Volume of table 1 Chinese medicine composition of the present invention
Note: compared with negative control group, * P < 0.05, * * P < 0.01.
nullThe experimental result of table 1 shows that the body weight of negative control group rat substantially overweights the body weight of 60 age in days left and right SD female on average about 250g，It is consistent with fat sign of polycystic ovarian syndrome，The ovary weight of SD rat substantially increases，Ovarian Volume enlarges markedly，Also it is consistent with the sign of polycystic ovarian syndrome，Indicate polycystic ovarian syndrome modeling of the present invention success，And take the body weight opened after the ball of palace SD rat、The increase of ovary weight and Ovarian Volume has certain mitigation，Show that opening palace ball has certain therapeutic effect for polycystic ovarian syndrome，After taking the Chinese medicine composition of the embodiment of the present invention 1, the body weight of rat increases substantially suppressed，Its body weight is close to the average weight of 60 age in days normal female rats，Ovary weight and Ovarian Volume are also significantly less than negative control group，Also it is significantly less than simultaneously and opens palace ball group，Indicate the Chinese medicine composition of the present invention ovary weight of polycystic ovarian syndrome to be increased and Ovarian Volume increase has obvious inhibitory action，Show the present composition significant therapeutic effect for polycystic ovarian syndrome，And its therapeutic effect is substantially better than and opens palace ball group，Therefore，Can be used for the prevention of polycystic ovarian syndrome and/or treatment.
Above example is only enumerating of the present invention, each falls within protection scope of the present invention with the technical scheme of Chinese medicine composition of the present invention prevention and/or treatment polycystic ovarian syndrome and relevant disease thereof.
Present invention merely illustrates some claimed specific embodiments; technical characteristic described in one of them or more technical scheme can be combined with arbitrary one or more technical schemes; the technical scheme that these are combined and obtain is also in the application protection domain, technical scheme that is combined just as these and that obtain specifically has been recorded in the disclosure of invention.
Claims (4)
1. a Chinese medicine composition for prevention and/or treatment polycystic ovarian syndrome, is characterized by be made up of following crude drug: Radix Bupleuri 8-10 part, Semen Cuscutae 5-8 part, Colla Plastri Testudinis 5-8 part, Herba Cistanches 5-8 part, Stigma Croci 3-5 part, Endoconcha Sepiae 3-5 part, Placenta Hominis 1-3 part, Olibanum 1-3 part, Radix Glycyrrhizae Preparata 1-3 part.
2. the Chinese medicine composition of prevention according to claim 1 and/or treatment polycystic ovarian syndrome, it is characterised in that be made up of following crude drug: Radix Bupleuri 10 parts, Semen Cuscutae 8 parts, Colla Plastri Testudinis 6 parts, Herba Cistanches 6 parts, Stigma Croci 5 parts, Endoconcha Sepiae 5 parts, Placenta Hominis 2 parts, Olibanum 2 parts, Radix Glycyrrhizae Preparata 3 parts.
3. the purposes in the medicine of preparation prevention and/or treatment polycystic ovarian syndrome of the Chinese medicine composition described in claim 1 or 2.
4. prevention described in claim 1 or 2 and/or treat the preparation method of Chinese medicine composition of anti-polycystic ovarian syndrome, it is characterised in that comprise the following steps:
(1) pulverize: Colla Plastri Testudinis, Herba Cistanches, Placenta Hominis, frankincense powder are broken to 80-100 order, obtain mixed-powder one, and Radix Bupleuri, Semen Cuscutae, Stigma Croci, Endoconcha Sepiae, Radix Glycyrrhizae Preparata are crushed to 20-50 order, obtain mixed-powder two；
(2) extracting: mixed-powder two adds its purified water of weight 8-15 times and decocts 1-2 time, mixed extract obtains crude extract；
(3) concentration: when crude extract vacuum drying is to room temperature, relative density is the condensed cream of 1.03-1.06；
(4) condensed cream stirs after adding mixed-powder one, crushed after being dried, obtains present invention prevention and/or the Chinese medicine composition of prevention polycystic ovarian syndrome.
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| CN201610378886.2A CN105796782B (en) | 2016-05-31 | 2016-05-31 | A kind of Chinese medicine composition for preventing and/or treating Stein-Leventhal syndrome and its preparation method and application |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106237027A (en) * | 2016-08-08 | 2016-12-21 | 周艳丽 | A kind of pharmaceutical composition treating gynaecopathia and preparation method thereof |
| CN114949060A (en) * | 2022-06-10 | 2022-08-30 | 广东罗浮山国药股份有限公司 | Composition for conditioning polycystic ovarian syndrome and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167850A (en) * | 2007-10-20 | 2008-04-30 | 徐究竟 | Medicine for treating polycystic ovary syndrome and preparation technology thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167850A (en) * | 2007-10-20 | 2008-04-30 | 徐究竟 | Medicine for treating polycystic ovary syndrome and preparation technology thereof |
Non-Patent Citations (1)
| Title |
|---|
| 徐莲薇等: "补肾活血调周法治疗多囊卵巢综合征疗效观察", 《上海中医药杂志》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106237027A (en) * | 2016-08-08 | 2016-12-21 | 周艳丽 | A kind of pharmaceutical composition treating gynaecopathia and preparation method thereof |
| CN106237027B (en) * | 2016-08-08 | 2017-07-14 | 周艳丽 | It is a kind of to treat pharmaceutical composition of gynecological disease and preparation method thereof |
| CN114949060A (en) * | 2022-06-10 | 2022-08-30 | 广东罗浮山国药股份有限公司 | Composition for conditioning polycystic ovarian syndrome and preparation method thereof |
| CN114949060B (en) * | 2022-06-10 | 2023-04-07 | 广东罗浮山国药股份有限公司 | Composition for conditioning polycystic ovarian syndrome and preparation method thereof |
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