CN105796780A

CN105796780A - Traditional Chinese medicine for treating fibromyalgia syndrome and preparation method thereof

Info

Publication number: CN105796780A
Application number: CN201610289267.6A
Authority: CN
Inventors: 周鑫
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-05-04
Filing date: 2016-05-04
Publication date: 2016-07-27

Abstract

The invention provides a traditional Chinese medicine for treating fibromyalgia syndrome and a preparation method thereof. The traditional Chinese medicine comprises the following raw materials: fourleaf peperomia herb, broomjute sida herb, neocinnamomum hainanianum allen, euonymus aculeatus hemsl, goldhair hedyotis herb, euonymus laxiflorus, tupistra fimbriata, Chinese milkvetch herb, primula forrestii, starry saussurea herb, common mappianthus stem, drosera peltata, coniogramme intermedia, and common christia herb. The traditional Chinese medicine provided by the invention has the beneficial effects of being capable of treating fibromyalgia syndrome in combination with conventional Western medicines, being high in curative effect, having no toxic or side effects, and being lower in adverse reaction rate, and simple in preparation process.

Description

A kind of Chinese medicine treating fibromyalgia syndrome and preparation method

Technical field

The present invention relates to containing the medicinal preparation deriving from plant, animal or mineral component, particularly relate to a kind of Chinese medicine treating fibromyalgia syndrome and preparation method.

Background technology

Fibromyalgia syndrome is a kind of non-specific rheumatism, stiff for feature with chronic popularity musculoskeletal pain, and with fatigue, anxiety, sleep disorder, irritable bowel disease etc., has pressure pain point at privileged sites.The nineties is beautiful, Jia Deng state scholar has worked out international rheumatism association fibrillar muscle pain criteria for classification, names this disease into fibromyalgia syndrome.

Fibromyalgia syndrome is more common in women, and modal age of onset is 25～45 years old.Its clinical manifestation is varied, but mainly has following 4 groups of symptoms.1. cardinal symptom: whole body generalized plain and the pressure pain point being widely present are the symptoms that all fibres muscle pain syndrome patient has.Pain spreads all over whole body everywhere, especially with Axial sketelon (neck, thoracic vertebra, lower back portion) and pectoral girdle, pelvic girdle etc. for common.Other common site are followed successively by knee joint, hands, elbow, ankle, foot, the upper back of the body, the middle back of the body, wrist, buttocks, thigh and shank.This pain is depicted as twinge by most patients, and pain must make one nervous meaning disorderly.Patient's Chang Zishu arthralgia, but make detailed inquiries, answer title joint, muscle even skin all pains.The symptom that another all patients have is the pressure pain point being widely present, and these pressure pain points are present in tendon, muscle and hetero-organization thereof, often symmetrically property distribution.At pressure pain point position, patient is different to the reaction of " pressing " from normal person, but at other positions then indistinction.Measure with dolorimeter, lower than the pressure of normal person, tenderness can be drawn.2. characteristic symptom: it is stiff that this group symptom includes sleep disorder, fatigue and morning.The patient of about 90% has sleep disorder, shows as insomnia, Yi Xing, dreaminess, lassitude.The patient of 50%～90% has feeling of fatigue, and about half patient fatigue symptom is more serious, and morning, deadlock saw the patient of 76%～91%, and its order of severity is relevant with sleep and Disease Activity.3. common sympton: be most commonly that numbness and swelling in this group symptom.Patient often tells joint, periarticular swelling, but without objective sign.Secondly for headache, irritable bowel syndrome.Headache can divide migraine or non-migraine headache, and the latter is a kind of repressive dull pain in occipital region or whole head.Psychological abnormality includes depressed and anxiety is also relatively common.Additionally, patient's work capacity declines, the patient of about 1/3 need to change work post, and a minority can not adhere to routine work.Above symptom often because weather is damp and cold, psychentonia, overworked and increase the weight of.4. mixing symptom: Primary fibromyalgia syndrome rarely found major part fibromyalgia syndrome patient suffers from certain rheumatism simultaneously.At this moment clinical symptoms is the intertexture of both symptoms with overlapping.

Fibromyalgia syndrome belongs to Chinese medicine " arthromyodynia " category.This onset of disease mostly is overwork, multiple because nursing accidentally, or because feelings will is smooth, depression of liver-QI, and it is smooth to cause whole body QI-blood circulation, then by exopathogen, the heresy causing cold-damp is strongly fragrant in the flesh natural fibre line of meat, causes vim and vigour to lose and causes stagnated QI in Xuan Tonger and break out, therefore its disease is based on the flesh natural fibre line of meat.

Summary of the invention

The technical problem to be solved is in that, it is provided that a kind of Chinese medicine treating fibromyalgia syndrome and preparation method, and fibromyalgia syndrome is had definite curative effect by Chinese medicine of the present invention, has no side effect.

In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine treating fibromyalgia syndrome, its raw medicinal material includes: Herba Seu Radix Peperomiae Tetraphyllae, Herba Sidae Rhombifoliae, Mu Dali king, little a thousand pieces of gold, Herba Hedyotidis Chrysotrichae, the mountain Cortex Eucommiae, Yunnan Rohdea japonica, Herba Astragali Sinici, Radix Primulae forrestii, Herba saussureae stellae, Caulis Mappianthi Iodoidis, Herba Droserae Lunatae, black brave seven and Herba Christiae.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Seu Radix Peperomiae Tetraphyllae 10～20 parts, Herba Sidae Rhombifoliae 30～40 parts, Mu Dali king 5～15 parts, little a thousand pieces of gold 15～25 parts, Herba Hedyotidis Chrysotrichae 5～15 parts, the mountain Cortex Eucommiae 45～55 parts, Yunnan Rohdea japonica 10～20 parts, Herba Astragali Sinici 30～40 parts, Radix Primulae forrestii 15～25 parts, Herba saussureae stellae 10～20 parts, Caulis Mappianthi Iodoidis 5～15 parts, Herba Droserae Lunatae 5～15 parts, black brave 7 45～55 parts and Herba Christiae 10～20 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Seu Radix Peperomiae Tetraphyllae 10～15 parts, Herba Sidae Rhombifoliae 30～35 parts, Mu Dali king 5～10 parts, little a thousand pieces of gold 15～20 parts, Herba Hedyotidis Chrysotrichae 5～10 parts, the mountain Cortex Eucommiae 45～50 parts, Yunnan Rohdea japonica 10～15 parts, Herba Astragali Sinici 30～35 parts, Radix Primulae forrestii 15～20 parts, Herba saussureae stellae 10～15 parts, Caulis Mappianthi Iodoidis 5～10 parts, Herba Droserae Lunatae 5～10 parts, black brave 7 45～50 parts and Herba Christiae 10～15 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Herba Seu Radix Peperomiae Tetraphyllae 14 parts, Herba Sidae Rhombifoliae 33 parts, Mu Dali king 9 parts, little a thousand pieces of gold 18 parts, Herba Hedyotidis Chrysotrichae 7 parts, the mountain Cortex Eucommiae 46 parts, Yunnan Rohdea japonica 11 parts, Herba Astragali Sinici 31 parts, Radix Primulae forrestii 16 parts, Herba saussureae stellae 12 parts, Caulis Mappianthi Iodoidis 6 parts, Herba Droserae Lunatae 8 parts, black brave 7 49 parts and Herba Christiae 13 parts.

The preparation method that present invention also offers above-mentioned Chinese medicine, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step: be mixed in proportion by the described each raw medicinal material of Chinese medicine preparation preparation, adds the ethanol that determining alcohol is 80～90% relative to mixture quality 3～5 times, is heated to reflux 1～2 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80～90% relative to medicinal residues quality 2～4 times, be heated to reflux 30～50 minutes, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；

Second step: be placed in super micron mill by the dry cream that the first step obtains and pulverize 1～2 hour, pulverizes and sieves the micropowders of acquisition 100～200 order；

3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.2～0.4 times, the starch of 0.2～0.4 times, the magnesium stearate of 0.002～0.02 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is loaded in capsule housing, namely obtains capsule finished product.

The preparation method that present invention also offers above-mentioned Chinese medicine, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step: be mixed in proportion by each for described Chinese medicine raw medicinal material, adds the ethanol that determining alcohol is 70～80% relative to mixture quality 2～4 times, is heated to reflux 2～3 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 70～80% relative to described medicinal residues quality 1～3 times, be heated to reflux 1～2 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；

Second step: be placed in super micron mill by the dry cream that the first step obtains and pulverize 1～2 hour, pulverizes, sieves, it is thus achieved that the micropowders of 100 order～200 orders；

3rd step: add the starch relative to its quality 3～5 times in the micropowders obtained by second step, mixing, it is thus achieved that powder.

Beneficial effects of the present invention: Chinese medicine of the present invention can combine conventional western medicine treatment fibromyalgia syndrome, and curative effect is higher, has no side effect, and untoward reaction rate is lower, and preparation technology is simple.

Detailed description of the invention

The invention provides a kind of Chinese medicine treating fibromyalgia syndrome, its raw medicinal material includes: Herba Seu Radix Peperomiae Tetraphyllae, Herba Sidae Rhombifoliae, Mu Dali king, little a thousand pieces of gold, Herba Hedyotidis Chrysotrichae, the mountain Cortex Eucommiae, Yunnan Rohdea japonica, Herba Astragali Sinici, Radix Primulae forrestii, Herba saussureae stellae, Caulis Mappianthi Iodoidis, Herba Droserae Lunatae, black brave seven and Herba Christiae.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Herba Seu Radix Peperomiae Tetraphyllae: [another name] Semen Sojae Preparatum Herba Pyrolae, rock muscle grass, Semen Sojae Preparatum Viola arcuata, Semen Benincasae deer rank, Semen Benincasae Herba Asari, Herba Sedi tetractini, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Moghania fluminalis(C. B. Clarke) Li lobe, Semen Sojae Preparatum grass, roundleaf Semen Benincasae dish, stone is revived after death, rock is spent, stone on watt slurry, Herba Anotis ingratae, 3 years grass.[source] comes from " Zhiwu Mingshi Tukao ".[source] medical material Ji Yuan: for the herb of Piperaceae plant Herba Seu Radix Peperomiae Tetraphyllae or hair YEDOU lobe.Gather and store: Xia Qiu gathers, cleaning, dry or using fresh herb.[nature and flavor] are pungent；Bitter；Tepor.[return through] lung；Liver；Spleen channel.[function cures mainly] relaxing muscles and tendons to promote blood circulation；Expelling wind and removing dampness；Preventing phlegm from forming and stopping coughing.Main bones and muscles pain due to rheumatism；Traumatic injury；Furuncle toxic swelling；Pharyngolaryngitis；Stomatitis；Dysentery；Watery diarrhea；Dyspepsia does not disappear；Infantile malnutrition；Epersalgia cough；Asthma；Pertussis.[extracts] " China's book on Chinese herbal medicine "

Herba Sidae Rhombifoliae: [another name] big Herba Violae, Hemerocallis citrina Baroni paddy pull out, draw out the pus disappear, gluing, Hemerocallis citrina Baroni is violent, very heavy then, Folium seu radix sidae mysorensis, weak grass, small capital Herba Malvastri Coromandeliani, thin fan's hitching post, Hemerocallis citrina Baroni ground cross-stitch work, Folium sidae alnifoliae, Hemerocallis citrina Baroni are violent, Herba Gnaphalii Adnati, Radix sidae acutae, Catalpa, grass of sucking blood, raw pull, furuncle medicine, plum pulp branch Folium seu radix sidae mysorensis careless, hard, Huang Zaicao, gift rice grass, large size hemoptysis son Radix Salicis Babylonicae careless, terrible, the young grass of tree, Hemerocallis citrina Baroni Gu medicated porridge, fiber crops pen, pool Luo Da, the numb head of decomposite leaf snow, slope numb.[source] comes from " mountain of papers Chinese herbal medicine ".[source] medical material Ji Yuan: carry on the back the herb of Radix sidae acutae for Malvaceae plant in vain.Gathering and store: autumn gathers, cleaning, removing impurity, using fresh herb is dried, dries.[nature and flavor] sweet in the mouth；Pungent；Cool.[return through] heart；Liver；Lung；Large intestine；Small intestine meridian.[function cures mainly] clearing away heat-damp and promoting diuresis；Removing toxic substances and promoting subsidence of swelling.The high heat of main flu；Laryngopharynx swelling and pain；Damp-heat dysentery；Jaundice；Leukorrhagia；Stranguria；Rheumatism flaccidity is weak；Dizzy；Labor volume is weak；Hemorrhoidal bleeding；Carbuncle furuncle.[each discussion] 1. " Guangxi Chinese medicinal herbal ": refrigerant draw out pus by applying a plaster to the affected part, detumescence and apocenosis.Leaf: apply furuncle, furuncle.2. " Quanzhou book on Chinese herbal medicine ": heat clearing away dissipating blood stasis, cooling blood for hemostasis, control perianal abscess obstinate disease, hematochezia.3. Guang Wai army " conventional Chinese herbal medicine handbook ": dispelling wind to relieve the exterior syndrome, dissipating blood stasis report poison.Control influenza, flu, tonsillitis, enteritis, bacillary dysentery, panaris furuncle.4. Guangzhou air force " conventional Chinese herbal medicine handbook ": clearing away heat-damp and promoting diuresis, evacuation of pus granulation promoting.Harness the Yellow River subcutaneous ulcer, malaria, purulent inflammation.[extracts] " China's book on Chinese herbal medicine "

Mu Dali king: [source] medical material Ji Yuan: for the Herb of canella Folium Neocinnamomi Lecomtei.Gather and store: the four seasons can adopt, and is preferred with winter, using fresh herb or dry.[nature and flavor] are pungent；Temperature；Slightly poisonous.[return through] Liver Channel.[function cures mainly] expelling wind and removing dampness；Relaxing muscles and tendons to promote blood circulation；Promoting the circulation of QI to relieve pain.Main air pain of dampness syndrome；Lumbago；Puerperal bones and muscles pain；Stomachache；Diarrhoea；Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Little a thousand pieces of gold: [another name] hard muscle rattan.[source] medical material Ji Yuan: sting the root of winged euonymus for Celastraceae plant purple.Gathering and store: gathering after autumn, clean section is dried.[nature and flavor] are pungent；Micro-hardship；Temperature.[return through] Liver Channel.[function cures mainly] expelling wind and removing dampness；Relaxing muscles and tendons and activating QI and blood in the collateral.Main air pain of dampness syndrome；Osteopatia sprain.[extracts] " China's book on Chinese herbal medicine "

Herba Hedyotidis Chrysotrichae: [another name] apply ground Paspalum conjugatum, sill wind, Rhizoma et radix panici repentis, mountain Scolopendra, to leaf cun knotweed, white red sorrel, DIWUGONG, land Scolopendra, diarrhoea grass, wadding by grass, gold pin spoon, thin flowers and plants, boil on the nape opposite the mouth grass, Semen Benincasae grass, Semen arachidis hypogaeae grass, celestial being's Lysimachia christinae Hance, top flag, Caulis et Folium Pothi Repentis, Herba Alternantherae sessilis, turn over stone grass, cloth dish grass, wound grass, Herba Centipedae, Herba Hedyotidis Diffusae.[source] comes from " Zhejiang traditional herbal medicine ".[source] medical material Ji Yuan: for the herb of dicotyledon medicine Maguireothamnus speciosus Herba Hedyotidis Chrysotrichae.Gather and store: summer, autumn gather, drying or using fresh herb.[nature and flavor] bitter in the mouth；Cool in nature.[return through] liver；Gallbladder；Bladder；Large intestine channel.[function cures mainly] clearing away heat-damp and promoting diuresis；Subduing swelling and detoxicating.Main jaundice due to damp-heat；Have loose bowels；Dysentery；Herpes zoster；Oedema due to nephritis, chyluria；Treating swelling and pain by traumatic injury；Venom；Furuncle toxic swelling；Metrorrhagia；Leucorrhea；Traumatic hemorrhage.[each discussion] 1. " will planted by middle traditional Chinese medicines ": infusing drugs in wine or pan-fried water clothes, control impairment caused by overstrain hemorrhage, and have the function of relaxing muscles and tendons and activating QI and blood in the collateral；Mash deposited affected part, control innominate toxic swelling and sprain.2. " Zhejiang traditional herbal medicine ": scattered blood controls internal injury.3. " Hunan medicine will ": circulation of qi promoting dissipating blood stasis, heat-clearing and toxic substances removing, removing heat from blood, teeth consolidating, improving eyesight.4. " Zhejiang conventional medical herbs among the people ": heat clearing away, diuresis, suppressing the hyperactive liver.[extracts] " China's book on Chinese herbal medicine "

The mountain Cortex Eucommiae: [another name] flying apsaras is refuted.[source] medical material Ji Yuan: for root and the bark of the Celastraceae plant flower thinning Cortex Eucommiae.Gather and store: winter gathers, cutting into slices, dry.[nature and flavor] are sweet；Pungent；Tepor.[return through] liver；Kidney；Spleen channel.[function cures mainly] wind-damp dispelling；Bone and muscle strengthening；Promoting blood circulation and detoxication；Diuretic.Main air pain of dampness syndrome；Soreness of the waist and knees；Injury and bone fracture；Sore swollen toxin；Chronic hepatitis；Chronic nephritis；Edema.[extracts] " China's book on Chinese herbal medicine "

Yunnan Rohdea japonica: [another name] big Tupistra aurantiaca Wall et Backer, tupistra fimbriata.[source] medical material Ji Yuan: for herb or the rhizome of liliaceous plant tooth lobe Tupistra chinensis Bak..Gather and store: the whole year all can gather, cleaning, using fresh herb or dry.[nature and flavor] are pungent；Micro-hardship；Cool；Slightly poisonous.[function cures mainly] wind-damp dispelling；Heart tonifying diuresis；Antidote against snake bite.Main air pain of dampness syndrome；Cardiac edema；Venom.[extracts] " China's book on Chinese herbal medicine "

Herba Astragali Sinici: [another name] rice cloth bag, Hairy Bittercress, Astragalus sinicus, stick up flower, Bombyx mandarina Moore bean, Flos Nelumbinis youth, Flos Nelumbinis grass, flowers and plants, Eriocheir sinensis flower, Chinese enkianthus, rice umbrella flower, tealgrass, Strepopelia orientalis flower, Herba Astragali Sinici, rice huller screen flowers and plants, Semen astragali sinici, Herba Astragali Sinici, Flos Carthami youth, grass seed.[source] comes from " Zhiwu Mingshi Tukao ".[source] medical material Ji Yuan: for the herb of leguminous plant Herba Astragali Melilotoidis (Herba Astragali Sinici).Gather and store: spring, summer gather, cleaning, using fresh herb or dry.[nature and flavor] Gan Xin；Flat.[return through] heart；Liver；Lung meridian.[function cures mainly] heat-clearing and toxic substances removing, dispelling pathogenic wind for improving eyesight, cooling blood for hemostasis.Main throat pain, wind-phlegm is coughed, conjunctival congestion and swelling pain, furuncle, herpes zoster, scabies, hemorrhoid, bleeding from the gum, traumatic hemorrhage, menoxenia, leukorrhagia, thrombocytopenic purpura.[each discussion] 1. " Guizhou folk medicine ": Qinghuo Jiedu.Control furuncle, laryngalgia, hemorrhoid.2. " Shaanxi Chinese herbal medicine ": heat-clearing and toxic substances removing, detumescence of dispeling the wind.Control herpes zoster, furuncle.3. Jiangxi " medical herbs handbook ": dispelling pathogenic wind for improving eyesight, antipyretic diuresis.Control wind-phlegm cough, malaria, acute catarrhal conjunctivitis, traumatic hemorrhage.4. Soviet Union doctor " Chinese herbal medicine handbook ": control eye part disease, neuralgia.[extracts] " China's book on Chinese herbal medicine "

Radix Primulae forrestii: [another name] Cornu Cervi seven, the sincere popped rice of rock, pigtail seven, stone consumptive disease are joined.[source] medical material Ji Yuan: for the root and rhizome of Ofthe Primulaceae Primula forrestii Balf. f.Gather and store: autumn excavates, cleaning, dry or using fresh herb.[nature and flavor] are bitter；Pungent；Property is put down.[function cures mainly] wind-damp dispelling；Promoting blood circulation and hemostasis.Main air pain of dampness syndrome；Osteopatia sprain；Interior traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Herba saussureae stellae: [another name] Saussurea stella.[source] comes from " plateau Chinese herbal treatment handbook ".[source] medical material Ji Yuan: for the herb of feverfew Saussurea stella.Gather and store: JIUYUE is gathered, cleaning, dry.[nature and flavor] acrid in the mouth；Bitter；Property is put down.[function cures mainly] expelling wind and removing dampness；Tongluo Shujin.Main air temperature arthralgia pain；Muscle arteries and veins contracture.[extracts] " China's book on Chinese herbal medicine "

Caulis Mappianthi Iodoidis: [another name] rattan Radix Picriae felterrae, wind medicine, freeze GUFENG (" register planted by Guangxi medicine "), Caulis Mappianthi Iodoidis (" choosing of Simao, Yunnan Chinese herbal medicine "), Deng he rare (Dai Nationality's name).[source] " register planted by Guangxi medicine ".Herb that [source] is Icacinaceae plant hesperidium rattan or rattan.The whole year can adopt.Section is dried.[nature and flavor] " choosing of Simao, Yunnan Chinese herbal medicine ": " bitter, cool ".[function cures mainly] regulating menstruation and activating blood, expelling wind and removing dampness.Control menoxenia, dysmenorrhea, amenorrhea, rheumatic arthralgia.1. " register planted by Guangxi medicine ": " Herb: dispel the wind.Treating snakebite, infirmities and diseases ".2. " choosing of Simao, Yunnan Chinese herbal medicine ": " regulating menstruation and activating blood, hemostasis, pain relieving, centering, dehumidifying.Control menoxenia, dysmenorrhea, amenorrhea, puerperal blood deficiency, uterine contraction pain.Nervous cardiopalmus, rheumatic arthralgia, rheumatoid arthritis, the cruel arthralgia pain of waist, traumatic hemorrhage ".[extracts] " Chinese medicine voluminous dictionary "

Herba Droserae Lunatae: [another name] SHILONG wheatgrass, Fructus Linderae Glaucae, peppergrass, the summer without track, spend leaf, gold silk in vain, cannot not drip dryly, mountain region skin, catchfly, shichongcao, squid grass, Radix Indigoferae hancockii, Venus's-flytrap, fly net, Herba Phyllanthi Urinariae, enchanter's nightshade, calm automatic grass, underground jewel.[source] comes from supplementary Amplifications of the Compendium of Materia Medica.[source] medical material Ji Yuan: for the herb of Droseraceae plant Herba Droserae Lunatae or light calyx Herba Droserae Lunatae.Gather and store: the 5-6 month adopts, using fresh herb or dry.[nature and flavor] are sweet；Pungent；Flat；Nontoxic.[return through] spleen；Stomach；Lung meridian.[function cures mainly] wind-expelling pain-stopping；Invigorate blood circulation；Removing toxic substances.Main traumatic injury；Lumbar muscle strain；Stomachache；Flu；Laryngopharynx swelling and pain；Dysentery；Malaria；Infantile malnutrition；Corneal nebula；Scrofula；Eczema；Scabies.[extracts] " China's book on Chinese herbal medicine "

Black brave seven: [another name] Rhizoma Tupistrae ensifoliae, horsepower across, Cortex Ampelopsis Aconitifoliae Radicis, iron seven, black imperial seven, great Ye Canis familiaris L. tooth seven.[source] medical material Ji Yuan: for the rhizome of Hemionitidaceae plant Coniogramme intermedia Hieron..Gather and store: excavating rhizome autumn, removing fibrous root and earth, dry.[nature and flavor] are sweet；Light；Flat.[return through] bladder；Large intestine channel.[function cures mainly] eliminating damp-heat；Expelling wind and activating blood circulation.Main urine leaching is puckery；Dysentery；Have loose bowels；Leukorrhagia；Rheumatic arthralgia；Sore；Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Herba Christiae: [another name] HUDIECAO, sparrow hawk grass, butterfly wind.[source] comes from " Guangxi Chinese medicinal herbal ".[source] medical material Ji Yuan: for the herb of leguminous plant Vespertilio grass.Gather and store: herb of gathering in summer, autumn, cleaning, using fresh herb, or being beaten up and dry.[nature and flavor] Gan Weixin；Flat；Nontoxic.[return through] Liver Channel.[function cures mainly] promoting blood circulation by removing wind, removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome, traumatic injury, throat moth, cough due to lung-heat, carbuncle sore tumefacting virus, venom.[each discussion] 1. " Nanning City's medicine will ": relaxing muscles and tendons and activating QI and blood in the collateral, regulating menstruation blood stasis removing.Infusing drugs in wine clothes can strong muscles and bones；Decoct water clothes and control vicarious menstruation.Leaf: traumatic injury, synthetism are controlled in external application.2. " Guangxi Chinese medicinal herbal ": promoting blood circulation by removing wind, dissipating blood stasis for subsidence of swelling, pain relieving, antidote against snake bite.Control traumatic injury, rheumatic ostalgia, snake venom, ulcerative carbuncle.[extracts] " China's book on Chinese herbal medicine "

Hereinafter adopt embodiment to describe embodiments of the present invention in detail, fully understand that how application technology means are to solve technical problem for the present invention, reach technique effect and implement according to this whereby.

Embodiment 1: capsule

Take Herba Seu Radix Peperomiae Tetraphyllae 140g, Herba Sidae Rhombifoliae 330g, Mu Dali king 90g, little a thousand pieces of gold 180g, Herba Hedyotidis Chrysotrichae 70g, mountain Cortex Eucommiae 460g, Yunnan Rohdea japonica 110g, Herba Astragali Sinici 310g, Radix Primulae forrestii 160g, Herba saussureae stellae 120g, Caulis Mappianthi Iodoidis 60g, Herba Droserae Lunatae 80g, black brave seven 490g and Herba Christiae 130g；

Prepare according to the following steps:

The first step: be mixed in proportion by the described each raw medicinal material of Chinese medicine preparation preparation, adds the ethanol that determining alcohol is 90% relative to mixture quality 4 times, is heated to reflux 2 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80% relative to medicinal residues quality 3 times, be heated to reflux 50 minutes, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；

Second step: by the first step obtain dry cream be placed in super micron mill pulverize 1 hour, pulverize and sieve obtain 200 orders micropowders；

3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.3 times, the starch of 0.3 times, the magnesium stearate of 0.01 times, carry out mixing process, namely obtain capsule 's content, described Capsule content is loaded in capsule housing, namely obtains capsule finished product.

Embodiment 2: powder

Take Herba Seu Radix Peperomiae Tetraphyllae 110g, Herba Sidae Rhombifoliae 350g, Mu Dali king 60g, little a thousand pieces of gold 170g, Herba Hedyotidis Chrysotrichae 90g, mountain Cortex Eucommiae 490g, Yunnan Rohdea japonica 130g, Herba Astragali Sinici 330g, Radix Primulae forrestii 180g, Herba saussureae stellae 150g, Caulis Mappianthi Iodoidis 90g, Herba Droserae Lunatae 50g, black brave seven 470g and Herba Christiae 150g；

Prepare according to the following steps:

The first step: be mixed in proportion by each for described Chinese medicine raw medicinal material, adds the ethanol that determining alcohol is 70% relative to mixture quality 4 times, is heated to reflux 3 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 70% relative to described medicinal residues quality 3 times, be heated to reflux 2 hours, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；

Second step: be placed in super micron mill by the dry cream that the first step obtains and pulverize 2 hours, pulverizes, sieves, it is thus achieved that the micropowders of 200 orders；

3rd step: add the starch relative to its quality 4.3 times in the micropowders obtained by second step, mixing, it is thus achieved that powder.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 25～35g, carries out acute toxicity test.Mice is randomly divided into two groups, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 1, (concentration is 8.48g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.4 crude drugs/kg), and matched group gives normal saline, within one day, it is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Test result indicate that: compare with matched group, after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Capsule LD50 > 42.4 crude drugs/the kg of the Mouse oral gavage present invention, every day, maximum dosage-feeding was 84.8 crude drugs/kg/ day.The Chinese medicine clinical application amount of the present invention be 8.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.14g crude drug/kg/ day.By weighing machine: 606 times that the dosis tolerata of the Chinese medicine of mice (average weight with 30g) the oral administration gavage present invention is quantity.Therefore the Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 capsule of the present invention to three groups of mices (often group 20) by 13.88,22.32 and 43.56g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 3 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by Chinese medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 15 weeks and drug withdrawal 3 weeks, Organs of Mice is all without substantially changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety.

Clinical data:

Case selection: whole 90 example cases are my Out-patient Department patient.Patient is randomly divided into treatment group and matched group.Wherein treatment group 45 example, male 19 example, women 26 example, 21～62 years old age, the course of disease: 3 months～12 years.Matched group 45 example, male 20 example, women 25 example, 20～60 years old age, the course of disease: 3 months～11 years.Two groups there was no significant difference through statistical analysis in age, sex, the course of disease and coincident with severity degree of condition etc., have comparability.

Diagnostic criteria:

With reference to nineteen ninety Americanism damp disease association (ACR) about FMS classification diagnosis standard: (1) whole body diffusivity pain medical history, including the position pain simultaneously such as health both sides pectoral girdle and pelvic girdle, the top and the bottom of waist, Axial sketelon (cervical vertebra or shirtfront or thoracic vertebra or lower back), medical history is at least more than 3 months.(2) it is 4KG with thumb pressure, press and 18 pressure pain points have at least 11 or has tenderness above, such as occipitalia (under bilateral occipital bone muscle attachment place), lower cervical region (on front side of transverse process gap, bilateral C5～7), trapezius muscle portion (bilateral trapezius muscle upper limb midpoint), supraspinatus portion (double, two spine of scapula inner edges supraspinatus starting point), second rib portion (bilateral second rib and costicartilage connecting portion), condylus lateralis humeri portion (bilateral condylus lateralis humeri lower edge 2CM place), buttocks (the outside upper quadrant of bilateral buttocks, gluteus anterior fold place), greater trochanter portion (trailing edge of bilateral greater trochanter projection), knee (above bilateral knee joint space the nearside of joint, fat pad place, inner side fold line) etc..Meet above-mentioned two condition person simultaneously, and get rid of other rheumatism pain that such as Other diseases such as rheumatoid disease, polymyositis, dermatomyositis and hypothyroidism cause, namely diagnosable.

Therapeutic Method:

Matched group: give amitriptyline hydrochloride 25mg, take once before sleeping every night；Give ibuprofen modified release capsule (ibuprofen), one time 1,2 times on the one (sooner or later each once)；7 days courses for the treatment of, take 4 courses for the treatment of.

Treatment group: give amitriptyline hydrochloride 25mg, take once before sleeping every night；Oral Chinese medicine embodiment 1 capsule of the present invention, each 3, every day 3 times.One after each meal, 7 days courses for the treatment of, takes 4 courses for the treatment of.

Curative effect judging standard: cure: conscious pain disappears, without pain time movable, pressure pain point disappears.Effective: pain or tenderness alleviate, function is improved.Invalid: symptom, sign are all without improving.

Therapeutic outcome:

Group	n	Cure	Effectively	Invalid	Total effective
						Treatment group	45	21	22	2	43 (95.55%)
Matched group	45	13	24	8	37 (82.22%)

Treatment group compares with matched group, and treatment group curative effect is better than matched group, two groups of differences statistically significant (P < 0.05).

Untoward reaction: matched group 45 example, during treatment, there is hyperhidrosis in 3 examples, and xerostomia occur in 5 examples, and blurred vision occurs in 1 example, and 2 examples occur drowsiness, hepatic and renal function injure or other obvious adverse reaction all do not occur.Treatment group 45 example, during treatment, there is xerostomia in 2 examples, and 1 example occurs drowsiness, hepatic and renal function injure or other obvious adverse reaction does not all occur.

Concrete case: Cao, women, 36 years old.Whole body diffusivity pain medical history, including health both sides pectoral girdle and pelvic girdle, the top and the bottom of waist, Axial sketelon etc., simultaneously pain 2 years, position, are 4KG with thumb pressure, and pressing in 18 pressure pain points 13 has tenderness.Get rid of other rheumatism pain that such as Other diseases such as rheumatoid disease, polymyositis, dermatomyositis and hypothyroidism cause.Diagnosis is fibromyalgia syndrome.Give amitriptyline hydrochloride 25mg, take once before sleeping every night；Give Chinese medicine embodiment 1 capsule of the present invention, each 3, every day 3 times；After treating 2 weeks, conscious pain disappears, and without pain time movable, pressure pain point disappears, and cures.Follow up a case by regular visits to and do not recur half a year.

The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, and any those skilled in the art are changed or be modified as the Equivalent embodiments of equivalent variations possibly also with the technology contents of the disclosure above.But every without departing from technical solution of the present invention content, according to any simple modification, equivalent variations and remodeling that above example is made by the technical spirit of the present invention, still fall within the protection domain of technical solution of the present invention.

Claims

1. the Chinese medicine treating fibromyalgia syndrome, it is characterised in that each raw medicinal material of described Chinese medicine includes: Herba Seu Radix Peperomiae Tetraphyllae, Herba Sidae Rhombifoliae, Mu Dali king, little a thousand pieces of gold, Herba Hedyotidis Chrysotrichae, the mountain Cortex Eucommiae, Yunnan Rohdea japonica, Herba Astragali Sinici, Radix Primulae forrestii, Herba saussureae stellae, Caulis Mappianthi Iodoidis, Herba Droserae Lunatae, black brave seven and Herba Christiae.

2. Chinese medicine as claimed in claim 1, it is characterised in that the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Seu Radix Peperomiae Tetraphyllae 10～20 parts, Herba Sidae Rhombifoliae 30～40 parts, Mu Dali king 5～15 parts, little a thousand pieces of gold 15～25 parts, Herba Hedyotidis Chrysotrichae 5～15 parts, the mountain Cortex Eucommiae 45～55 parts, Yunnan Rohdea japonica 10～20 parts, Herba Astragali Sinici 30～40 parts, Radix Primulae forrestii 15～25 parts, Herba saussureae stellae 10～20 parts, Caulis Mappianthi Iodoidis 5～15 parts, Herba Droserae Lunatae 5～15 parts, black brave 7 45～55 parts and Herba Christiae 10～20 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterised in that the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Seu Radix Peperomiae Tetraphyllae 10～15 parts, Herba Sidae Rhombifoliae 30～35 parts, Mu Dali king 5～10 parts, little a thousand pieces of gold 15～20 parts, Herba Hedyotidis Chrysotrichae 5～10 parts, the mountain Cortex Eucommiae 45～50 parts, Yunnan Rohdea japonica 10～15 parts, Herba Astragali Sinici 30～35 parts, Radix Primulae forrestii 15～20 parts, Herba saussureae stellae 10～15 parts, Caulis Mappianthi Iodoidis 5～10 parts, Herba Droserae Lunatae 5～10 parts, black brave 7 45～50 parts and Herba Christiae 10～15 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterised in that the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Seu Radix Peperomiae Tetraphyllae 14 parts, Herba Sidae Rhombifoliae 33 parts, Mu Dali king 9 parts, little a thousand pieces of gold 18 parts, Herba Hedyotidis Chrysotrichae 7 parts, the mountain Cortex Eucommiae 46 parts, Yunnan Rohdea japonica 11 parts, Herba Astragali Sinici 31 parts, Radix Primulae forrestii 16 parts, Herba saussureae stellae 12 parts, Caulis Mappianthi Iodoidis 6 parts, Herba Droserae Lunatae 8 parts, black brave 7 49 parts and Herba Christiae 13 parts.

5. the Chinese medicine as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

6. the Chinese medicine as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

7. the preparation method of Chinese medicine described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

8. the preparation method of Chinese medicine described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps: