CN105796670A - Traditional Chinese medicine composition for treating headaches after spinal anesthesia - Google Patents
Traditional Chinese medicine composition for treating headaches after spinal anesthesia Download PDFInfo
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- 206010019233 Headaches Diseases 0.000 title claims abstract description 36
- 231100000869 headache Toxicity 0.000 title claims abstract description 36
- 239000003814 drug Substances 0.000 title claims abstract description 33
- 238000002693 spinal anesthesia Methods 0.000 title claims abstract description 25
- 239000000203 mixture Substances 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 claims abstract description 13
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
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- A—HUMAN NECESSITIES
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- A61K2236/50—Methods involving additional extraction steps
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- A—HUMAN NECESSITIES
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Abstract
The invention relates to traditional Chinese medicine composition for treating headaches after spinal anesthesia. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 18-25 parts of shrubby breynia, 20-28 parts of actaea roots, 15-20 parts of nothopanax delavayi, 10-16 parts of roots of griffith streptocaulon, 20-30 parts of garden euphorbia herbs and 15-20 parts of desmodium triflorum. The invention further discloses a preparation method. The traditional Chinese medicine composition can treat the headaches after spinal anesthesia.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, treat the Chinese drug-treated group of headache after spinal anesthesia in particular to a kind of
Compound.
Background technology
After spinal anesthesia, headache is one of common complication of subarachnoid anesthesia (lumbar anesthesia), often caused by puncture needle
The pin hole stayed on spinal dura mater constantly spills cerebrospinal fluid and is caused.Typical case's headache can be sent out in 6-12h after piercing
Raw, majority is fallen ill the 1-3d after ridge fiber crops.Spinal headache is persistently spilt by puncturing hole mainly due to cerebrospinal fluid, brain ridge
Hydraulic coupling reduces, so that meningovascular and cranial nerve are by caused by tractive.Patient is through infusion and symptomatic treatment a couple of days for major part
Interior symptom can be alleviated, but small part heavy type patient is the best through general treatment, even recurrent exerbation.
Summary of the invention
The invention provides and a kind of treat Chinese medicine composition of headache and preparation method thereof after spinal anesthesia.
The present invention realizes particular by following technical scheme:
A kind of treat the Chinese medicine composition of headache after spinal anesthesia, the crude drug of following weight portion be prepared from: Folium et cacumen Breyniae Fruticosae
18-25 part, Rhizoma actaeae asiaticae 20-28 part, Herba seu Radix Nothopanacis delavayi 15-20 part, Radix Streptocauli Griffithii 10-16 part, Ramulus et Folium Bauhiniae Faberi 20-30 part,
3 gold grass 15-20 parts.
After described treatment spinal anesthesia, the Chinese medicine composition of headache, is prepared from by the crude drug of following weight portion: black
20 parts of face leaf, Rhizoma actaeae asiaticae 24 parts, Herba seu Radix Nothopanacis delavayi 17 parts, Radix Streptocauli Griffithii 13 parts, Ramulus et Folium Bauhiniae Faberi 25 parts, 3 gold grass 18
Part.
The Chinese medicine composition of headache after described treatment spinal anesthesia, dosage form is granule, tablet, oral liquid, capsule.
The Chinese medicine composition of headache after described treatment spinal anesthesia, preparation method comprises the steps: that taking above-mentioned medical material closes
And, boiling twice, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, adds ethanol, stirs,
Make alcohol content by volume percentage calculation reach 65-85%, stand, filter, relative density during filtrate reduced in volume to 65 DEG C
For 1.20-1.30 and reclaim ethanol, being spray-dried by concentrated solution, gained granular powder is broken into dry extract, adds adjuvant,
Make required preparation.
The Chinese medicine composition of headache after described treatment spinal anesthesia, in described preparation method, decocting condition is: add for the first time
The water yield is the 8-12 times amount of medical material weight, decocts 1-2h, and amount of water is the 6-10 times amount of medical material weight for the second time, decocts
Boil 1-2h.
The Chinese medicine composition of headache after described treatment spinal anesthesia, in described preparation method, spray drying condition is: air intake
Temperature is 90-110 DEG C, and leaving air temp is 60-90 DEG C, and temperature of charge is 60-90 DEG C, and atomizing pressure is 0.2-0.5
MPa, spray velocity is 1-10ml/s.
The Chinese medicine composition of headache application in preparation treatment headache medicine after described treatment spinal anesthesia.
Folium et cacumen Breyniae Fruticosae is the browse of euphorbia plant Folium et cacumen Breyniae Fruticosae.Upright shrub, high 2～3 meters.Bark taupe brown, branch
Cylindric, multi-fork sigmoid, there is white tiny hole skin on surface.Heat-clearing and toxic substances removing, dissipating blood stasis, pain relieving, antipruritic.Root: acute
Gastroenteritis, tonsillitis, bronchitis, lithangiuria, puerperal uterine contraction pain, rheumatic arthritis.Leaf: outer
With controlling burn and scald, eczema, allergic dermatitis, skin itching, vaginitis.
Rhizoma actaeae asiaticae is Ranunculaceae baneberry cohosh Actaea asiatica Hara, with root stock and
All herbal medicine.Autumn gathers, and dries respectively.Clearing away lung-heat to relieve cough, heat-clearing and toxic substances removing.For headache due to common cold, pertussis.External
Control lyssodexis.The present invention uses all herbal medicine.
Herba seu Radix Nothopanacis delavayi is Herb or the root of Araliaceae Nothopanax, gathers in spring, summer, cleans using fresh herb or dries use.
Heat-clearing and toxic substances removing, relaxing muscles and tendons to promote blood circulation.For acute pharyngitis, acute conjunctivitis, dyspepsia, lumbago, skelalgia of rheumatism；Bone is controlled in external
Folding, traumatic injury.The present invention is used as medicine with Herb.
Radix Streptocauli Griffithii is that trailing plants rattan Ke Malian saddle platymiscium horse connects saddle Streptoculon griffithii Hook.f. and enters with root
Medicine.The whole year can adopt, using fresh herb or dry use.Heat-clearing and toxic substances removing, scattered silt pain relieving.For cat fever, enteritis, dysentery, stomach
Bitterly, treating swelling and pain by traumatic injury, venom.
Ramulus et Folium Bauhiniae Faberi is the dry herb of Ramulus et Folium Bauhiniae Faberi Euphorbia hirta Linn., annual herb, Herba Euphoubiae Hirtae decocting
Agent all has inhibitory action to staphylococcus aureus, bacillus pyocyaneus.There are diuresis and moderate catharsis effect.Heat-clearing and toxic substances removing, profit
Wet antipruritic.For bacillary dysentery, amebic dysentery, enteritis, intestinal infusorian, dyspepsia, bronchitis, renal pelvis
Nephritis；Eczema, dermatitis, skin pruritus are controlled in external.
3 gold grass, formal name used at school: Desmodium triflorum (L.) DC.), pulse family, Papillionoideae, Desmodium racemosum Thunb.
Race, promoting the circulation of QI to relieve pain, dispelling cold by warming the meridian, removing toxic substances.For heatstroke suffer from abdominal pain, colicky, menoxenia, dysmenorrhea, puerperal joint
Bitterly, rabies.The present invention is with all herbal medicine.
Compared with prior art, Folium et cacumen Breyniae Fruticosae of the present invention, Rhizoma actaeae asiaticae, Herba seu Radix Nothopanacis delavayi heat-clearing and toxic substances removing, dissipating blood stasis, pain relieving is monarch drug,
Radix Streptocauli Griffithii, Ramulus et Folium Bauhiniae Faberi heat-clearing and toxic substances removing are ministerial drug, 3 gold grass promoting the circulation of QI to relieve pain adjuvants, have a headache after being used for treating spinal anesthesia.
Specific embodiment
Following example further describe beneficial effects of the present invention, and embodiment is only used for the purpose of illustration, is not intended to this
Bright protection domain, those of ordinary skill in the art is obviously changed according to what the present invention made and modifies also simultaneously
Comprise within the scope of the present invention.
Embodiment 1: weigh medical material Folium et cacumen Breyniae Fruticosae 18 parts, Rhizoma actaeae asiaticae 28 parts, Herba seu Radix Nothopanacis delavayi 15 parts, Radix Streptocauli Griffithii 10 parts, fly upward
Careless 30 parts, 3 golden careless 15 parts, mixing, boiling twice, add water 8 times amount into medical material weight for the first time, decoction
1.5h, add water 6 times amount into medical material weight for the second time, decocts 1h, collecting decoction, filters, and filtrate is concentrated into the closeest
Degree 1.10 (65 DEG C), add ethanol in proper amount and make alcohol content (volume fraction) reach 65%, stir, stand 24 hours, filter,
Filtrate recycling ethanol is also concentrated into the concentrated solution of relative density 1.20 (65 DEG C), and spray-dried (condition is inlet temperature
Being 100 DEG C, leaving air temp is 80 DEG C, and temperature of charge is 80 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.),
It is ground into dry extract, adds suitable dextrin, mix homogeneously, with appropriate 80% ethanol wet, soft material processed, cross 14 mesh
Sieve series grain, 70 DEG C are dried, and 60 mesh granulate obtain granule.
Embodiment 2: weigh medical material Folium et cacumen Breyniae Fruticosae 25 parts, Rhizoma actaeae asiaticae 20 parts, Herba seu Radix Nothopanacis delavayi 20 parts, Radix Streptocauli Griffithii 10 parts, fly upward
Grass 30 parts, 3 gold grass 15 parts, mixing, boiling twice, the 10 times amount into medical material weight that add water, decoct 2h,
Add water 8 times amount into medical material weight for the second time, decocts 1h, collecting decoction, filters, and filtrate is concentrated into relative density 1.15
(65 DEG C), add ethanol in proper amount and make alcohol content (volume fraction) reach 75%, stir, stand 24 hours, filter, filtrate
Reclaiming ethanol and be concentrated into the concentrated solution of relative density 1.25 (65 DEG C), spray-dried (condition is that inlet temperature is
120 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 80 DEG C, and atomizing pressure is 0.3 MPa, and spray velocity is 7.5/s.),
It is ground into dry extract, adds appropriate Icing Sugar, mix homogeneously, with appropriate 80% ethanol wet, soft material processed, cross 30 mesh
Sieve series grain, is dried in 70～80 DEG C, and with 60 mesh sieve granulate, tabletting, sugar coating, subpackage, outer package, censorship is qualified,
Obtain finished product.
Embodiment 3: weigh medical material Folium et cacumen Breyniae Fruticosae 20 parts, Rhizoma actaeae asiaticae 24 parts, Herba seu Radix Nothopanacis delavayi 17 parts, Radix Streptocauli Griffithii 13 parts, fly upward
Careless 25 parts, 3 golden careless 18 parts, mixing, boiling twice, add water 12 times amount into medical material weight for the first time, decoction
2h, add water 10 times amount into medical material weight for the second time, decocts 2h, collecting decoction, filters, and filtrate is concentrated into relative density
1.20 (65 DEG C), add ethanol in proper amount and make alcohol content (volume fraction) reach 85%, stir, stand 24 hours, filter,
Filtrate recycling ethanol is also concentrated into the concentrated solution of relative density 1.30 (65 DEG C), with sucrose, propanoic acid 0.1% or benzoic acid
Sodium 0.1%～0.25% etc., as preservative, obtain oral liquid finished product.
Embodiment 4: weigh medical material Folium et cacumen Breyniae Fruticosae 20 parts, Rhizoma actaeae asiaticae 24 parts, Herba seu Radix Nothopanacis delavayi 17 parts, Radix Streptocauli Griffithii 13 parts, fly upward
Careless 25 parts, 3 golden careless 18 parts, mixing, boiling twice, add water 10 times amount into medical material weight for the first time, decoction
1.5h, add water 8 times amount into medical material weight for the second time, decocts 1.5h, collecting decoction, filters, and filtrate is concentrated into relatively
Density 1.15 (65 DEG C), adds ethanol in proper amount and makes alcohol content (volume fraction) reach 75%, stir, stand 24 hours, filter
Crossing, filtrate recycling ethanol is also concentrated into the extractum of relative density 1.25 (65 DEG C), and spray-dried (condition is air intake temperature
Degree is 120 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 90 DEG C, and atomizing pressure is 0.4 MPa, and spray velocity is
7.5/s.), be ground into dry extract, cross No. 6 sieves, reinstall No. 1 capsule finished product.
Embodiment 5: clinical trial data of the present invention
Clinical case: headache person 60 example after spinal anesthesia.Have a headache after spinal anesthesia patient age 24～63 years old, averagely
38.5 years old age；Male patient 30 example, female patient 30 example.Get rid of and there is psychiatric history or severe cardiovascular disease
Medical history person；All patients are without history of previously having a headache for a long time.60 examples are postoperative 1-3d and headache syndromes occur, its spy that has a headache
Levying and all have substantial connection with position, when sitting up or be upright, headache increases the weight of, especially with rear pillow part and head surrounding pain, some patients
With Nausea and vomiting, when lying on the back, headache alleviates, and all patients are all without heating or upper respiratory tract infection performance, blood pressure, the heart
Rate, all in normal range, gets rid of application headache caused by vasoactive agent.
Medicament selection: treatment group is taken the preparation method of above-described embodiment 1 and prepared medicine of the present invention, oral, every day 2
Secondary, the most each 1 time, each 10g, after meal warm water delivery service；Within 12 days, it is 1 course for the treatment of, can fully recover from an illness 2～4 courses for the treatment of
More, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.Matched group takes placebo, oral, bfore meals.
Efficacy determination: cure: transference cure checks normal without recurrence, laboratory；Effective: symptom alleviates, experiment
Room checks and makes moderate progress；Invalid: symptom and lab testing are all without improving.Therapeutic effect: be shown in Table 1.
1 liang of table group comparitive study
| Group | n | Cure | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 30 | 6 | 20 | 4 | 86.7 |
| Matched group | 30 | 1 | 2 | 27 | 10 |
The visible present invention has good therapeutic effect to headache after spinal anesthesia, and toxic and side effects does not occurs during treatment.
Claims (7)
1. the Chinese medicine composition having a headache after treating spinal anesthesia, it is characterised in that by the crude drug of following weight portion
Be prepared from: Folium et cacumen Breyniae Fruticosae 18-25 part, Rhizoma actaeae asiaticae 20-28 part, Herba seu Radix Nothopanacis delavayi 15-20 part, Radix Streptocauli Griffithii 10-16 part,
Ramulus et Folium Bauhiniae Faberi 20-30 part, 3 gold grass 15-20 parts.
2. the Chinese medicine composition of headache after treatment spinal anesthesia as claimed in claim 1, it is characterised in that by following heavy
Amount part crude drug be prepared from: Folium et cacumen Breyniae Fruticosae 20 parts, Rhizoma actaeae asiaticae 24 parts, Herba seu Radix Nothopanacis delavayi 17 parts, Radix Streptocauli Griffithii 13 parts,
Ramulus et Folium Bauhiniae Faberi 25 parts, 3 gold grass 18 parts.
3. the Chinese medicine composition having a headache after treating spinal anesthesia as claimed in claim 1, it is characterised in that dosage form is granule
Agent, tablet, oral liquid, capsule.
4. the Chinese medicine composition having a headache after treating spinal anesthesia as claimed in claim 1, it is characterised in that preparation method bag
Include following steps: taking above-mentioned medical material and merge, boiling twice, collecting decoction, when being concentrated into 65 DEG C, relative density is
1.10-1.20, adds ethanol, stirring, makes alcohol content by volume percentage calculation reach 65-85%, stand, filter, filter
When liquid is evaporated to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, is spray-dried by concentrated solution, gained granule
It is ground into dry extract, adds adjuvant, make required preparation.
5. the Chinese medicine composition having a headache after treating spinal anesthesia as claimed in claim 4, it is characterised in that described preparation
In method, decocting condition is: amount of water is the 8-12 times amount of medical material weight for the first time, decocts 1-2h, for the second time amount of water
For the 6-10 times amount of medical material weight, decoct 1-2h.
6. the Chinese medicine composition having a headache after treating spinal anesthesia as claimed in claim 4, it is characterised in that described preparation
In method, spray drying condition is: inlet temperature is 90-110 DEG C, and leaving air temp is 60-90 DEG C, and temperature of charge is
60-90 DEG C, atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
7. the Chinese medicine composition of headache application in treating headache medicine after treating spinal anesthesia as claimed in claim 1.
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Citations (4)
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|---|---|---|---|---|
| CN102614280A (en) * | 2012-04-23 | 2012-08-01 | 卞毓平 | Chinese medicinal composition with blood fat reducing effect, and preparation method and application thereof |
| CN104645149A (en) * | 2015-02-11 | 2015-05-27 | 王桂霞 | Traditional Chinese medicine composition for treating headache after spinal anesthesia |
| CN104784618A (en) * | 2015-04-23 | 2015-07-22 | 淄博齐鼎立专利信息咨询有限公司 | Traditional Chinese medicine composition for treating headache |
| CN105106440A (en) * | 2015-09-07 | 2015-12-02 | 陈红 | Traditional Chinese medicine composition for treating headache and dizziness induced by lumbar anesthesia |
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2016
- 2016-04-04 CN CN201610204547.2A patent/CN105796670A/en not_active Withdrawn
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|---|---|---|---|---|
| CN102614280A (en) * | 2012-04-23 | 2012-08-01 | 卞毓平 | Chinese medicinal composition with blood fat reducing effect, and preparation method and application thereof |
| CN104645149A (en) * | 2015-02-11 | 2015-05-27 | 王桂霞 | Traditional Chinese medicine composition for treating headache after spinal anesthesia |
| CN104784618A (en) * | 2015-04-23 | 2015-07-22 | 淄博齐鼎立专利信息咨询有限公司 | Traditional Chinese medicine composition for treating headache |
| CN105106440A (en) * | 2015-09-07 | 2015-12-02 | 陈红 | Traditional Chinese medicine composition for treating headache and dizziness induced by lumbar anesthesia |
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