CN105796442B - Multi-functional frost - Google Patents
Multi-functional frost Download PDFInfo
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- CN105796442B CN105796442B CN201610305346.1A CN201610305346A CN105796442B CN 105796442 B CN105796442 B CN 105796442B CN 201610305346 A CN201610305346 A CN 201610305346A CN 105796442 B CN105796442 B CN 105796442B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Abstract
The invention discloses a kind of multi-functional frosts, the multi-functional frost includes the first component, the second component and third component, first component includes the first skin conditioner and emulsifier, and the first skin conditioner includes vaseline, white pond flower seed oil, dimethyl silicone polymer and tocopherol acetate；Second component includes the second skin conditioner and Second addition, and the second skin conditioner includes bisabolol, N- palmityl hydroxy-proline cetyl, stearic acid, campesterol class and ginger-root extract；The third component includes water, glycerol, third skin conditioner and third additive, and the third skin conditioner includes dipotassium glycyrrhizinate, hydroxyisoleucine, pot marigold seed oil, Sodium Hyaluronate and hydrolysed rice albumen；Have the effect of it is mild it is non-stimulated, used suitable for baby.
Description
Technical field
The present invention relates to daily chemical product technical field, in particular to multi-functional frost.
Background technique
With the improvement of people ' s living standards and the concern to infantile health, enterprise are making great efforts to develop production relevant to baby
Product.The daily chemical product of baby is more in the market existing, but many parents still cannot select a kind of satisfaction for the child of oneself
Product.
Firstly, the average surface area of the skin of baby is 2500cm2, average weight 5kg, the ratio between the two is 1: 500, is formed
The average surface area of application on human skin is 18000cm2, and average weight 65kg, the ratio between the two is 1: 270, so washing for same amount
Shield product baby absorbs must be more than adult, meanwhile, it is also much strong to the reaction of allergin or toxic substance；Secondly, baby's skin
The sweat gland and blood vessel of skin are easy to produce hot miliaria when environment temperature increases also in development；In addition, the immune system of baby is still
It is imperfect, it is vulnerable, it is easier to skin allergy occur, such as erythema, papule, blister.However most of daily use chemicals on the market are used
There are stimulating component, part infant skins the allergic phenomenas such as erythema occurs for product.
The Chinese patent that application publication number is CN105395465A, data of publication of application is on March 16th, 2016 discloses one
Kind moisturizing whitening cream.It is by the material composition of following parts by weight: 5-8 parts of glycerol, 3-5 parts of Aloe essential liquid, green tea seed oil
5-8 parts, 8-15 parts of pearl powder, 3-5 parts of vitamin e acetate, 2-5 parts of lecithin wax, 5-8 parts of candelila wax, refining shea butter
8-15 parts, 8-20 parts of refined coconut oil, -8 parts of vitamin B3,1-5 parts of stearoxyl trimethyl silane, 3-15 parts of hyaluronic acid,
5-15 parts of microstage walnut powder, 5-8 parts of marine algae extract, 8-15 parts of molecular distillation monoglyceride, 10-15 parts of olive oil, arbutin 3-8
Part, 3-8 parts of saualane.
It is in place of the deficiencies in the prior art, when contacting the substances such as lecithin wax, candelila wax and microstage walnut powder, part
The skin of baby is stimulated, and will appear erythema allergy, so the face cream is not suitable for baby.
Therefore, developing a kind of mild non-stimulated multi-functional frost, there is certain production application to be worth.
Summary of the invention
The object of the present invention is to provide a kind of multi-functional frosts, which solve infant skin vulnerable to thorn after contacting daily chemical product
Sharp and anaphylactic problem, have the effect of it is mild it is non-stimulated, used suitable for baby.
Above-mentioned technical purpose of the invention has the technical scheme that
A kind of multi-functional frost, including the first component, the second component and third component,
First component includes the first skin conditioner and emulsifier, and the first skin conditioner includes vaseline, white
Pond flower seed oil, dimethyl silicone polymer and tocopherol acetate；
Second component includes the second skin conditioner and Second addition, and the second skin conditioner includes red not having
Medicine alcohol, N- palmityl hydroxy-proline cetyl, stearic acid, campesterol class and ginger-root extract；
The third component includes water, glycerol, third skin conditioner and third additive, the third skin conditioner
Including dipotassium glycyrrhizinate, hydroxyisoleucine, pot marigold seed oil, Sodium Hyaluronate and hydrolysed rice albumen.
Further preferably are as follows: first component: the second component: the weight fraction ratio of third component be 1: 1~1.5: 5~
20；
In first component, the weight fraction ratio of the first skin conditioner and emulsifier is 1: 1.2~3, the first skin
Conditioner by the vaseline of 10~40wt%, the white pond flower seed oil of 20~30wt%, 20~30wt% dimethyl silicone polymer and
The tocopherol acetate of tocopherol acetate and 20~30wt% composition.
Further preferably are as follows: the emulsifier by 25~75wt% cetyl PEG/PPG-10/1 dimethyl silicone polymer
It is constituted with the smooth isostearate of sorb of 25~75wt%.
Further preferably are as follows: in the second component, the weight fraction ratio of the second skin conditioner and Second addition is 1
: 1.5~5；The second skin conditioner is by the bisabolol of 20~40wt%, the N- palmityl hydroxyl dried meat ammonia of 15~20wt%
Sour cetyl, the stearic acid of 15~20wt%, the campesterol class of 15~20wt% and 15~20wt% ginger-root extract structure
At；Second addition is by the Nexbase 2004 of 10~30wt%, -18 hectorite of quaternary ammonium salt, the 10~25wt% of 10~25wt%
Vinyldimethicone/polymethyl siloxane silsesquioxane cross-linked polymer and 20~50wt% second dilution
Agent is constituted.
Further preferably are as follows: second diluent is gathered by the cyclohexasiloxane of 15~25wt%, the ring of 15~25wt%
Dimethyl siloxane, the ring five dimethyl silicone polymer of 15~25wt%, 15~25wt% cyclotetrapolydimethylsiloxane and
The hexyl decyl alcohol of 15~25wt% is constituted.
Further preferably are as follows: in third component, the weight of the water, glycerol, third skin conditioner and third additive
Portion rate is 1: 0.5~0.6: 0.05~0.3: 0.4~0.8；The third skin conditioner by 15~25wt% glycyrrhizic acid
Dipotassium, the hydroxyisoleucine of 15~25wt%, the pot marigold seed oil of 15~25wt%, 15~25wt% Sodium Hyaluronate and
The hydrolysed rice albumen of 15~25wt% is constituted；The third additive is by the sodium chloride of 20~35wt%, 20~35wt%
The third diluent of polyethylene glycol and 30~60wt% are constituted.
Further preferably are as follows: the third diluent by 25~75wt% butanediol and 25~75wt% 1,2- oneself two
Alcohol is constituted.
Further preferably are as follows: the Sodium Hyaluronate includes that the HA and Mr that Mr is (1~2) × 106 are (1~8) × 104
HA。
Further preferably are as follows: the multi-functional frost is prepared by the following method:
Step 1, the preparation of the first component fusant: measuring the first skin conditioner and emulsifier by formula, be dispersed with stirring,
It is heated to 55~68 DEG C and keeps the temperature, obtain the first component under finely dispersed molten condition；
Step 2, the preparation of oily phase: Second addition is measured by formula and is uniformly dispersed, is added to step 1 obtains first
In the fusant of component, it is dispersed with stirring；In the second skin conditioner that formula ratio is wherein added, it is dispersed with stirring, obtains oily phase；
Step 3, formula ratio water intaking, glycerol, third skin conditioner and third additive, stirring point the preparation of water phase: are pressed
It dissipates, is heated to 40~50 DEG C and keeps the temperature, obtain the water phase of dissolved clarification；
Step 4, emulsion process: the water phase that step 3 is obtained is slowly added into the oily phase that step 2 obtains, and is dispersed with stirring simultaneously
Homogeneous to get.
Further preferably are as follows: in the step 2, the finely dispersed degree of Second addition are as follows: add second after dispersion
Agent is added to be dispersed to spreadable grainless on coverslip.
In conclusion the invention has the following advantages:
The raw material that the application uses is non-stimulated or low stimulation, and does not generate irritation product after its mixing, in skin urgency
The result of sexual stimulus test and multiple skin irritatin test be it is nonirritant, it is mild non-stimulated, be suitable for baby and use；
The application uses multiple moisturizer, in addition to skin and external environment is isolated, reduces the loss of moisture, moreover it is possible to utilize load
Interaction between body and moisturizer, carrier and skin transports part moisturizer to skin, and skin is made to obtain deep layer
Moist and moisturizing from this and puts on the ability to improve its moisturizing water lock；It finds, is used in combination in normal individual trial test
Afterwards, the multi-functional frost of the application has better moisture retention, the skin that can preferably protect baby tender；Meanwhile the application
Multicomponent all have the function of moisturizing, the feeling of baby feel comfortable can be given, further increase the quality of product；
The application uses multiple antiallergic ingredient, situations such as in addition to that can prevent infantile eczema, milk moss and be chapped from the cold, milk moss and/
Or normal individual trial test discovery of being chapped from the cold, after being used in combination, the multi-functional frost of the application also has treatment eczema, milk moss and/or chapped
The effect split can preferably safeguard the tender skin of baby；
For the application using a variety of nonirritant emulsifiers, additive etc., a combination thereof acts on other raw materials of the application
Afterwards, product is stable and quality is controllable (referring to stability test)；It is prepared simultaneously using the preparation method of the application multi-functional
Frost can be further improved its stability, find during stability test, and property is substantially unchanged, relatively stable.
Specific embodiment
This specific embodiment is only explanation of the invention, is not limitation of the present invention, those skilled in the art
Member can according to need the modification that not creative contribution is made to the present embodiment after reading this specification, but as long as at this
All by the protection of Patent Law in the scope of the claims of invention.
Embodiment 1-5: multi-functional frost is prepared by the following method:
Step 1, the preparation of the first component fusant: measuring the first skin conditioner and emulsifier by formula, be dispersed with stirring,
It is heated to 55~68 DEG C and keeps the temperature, obtain the first component under finely dispersed molten condition；
Step 2, the preparation of oily phase: measuring Second addition by formula and be uniformly dispersed, the finely dispersed journey of Second addition
Degree are as follows: the Second addition after dispersion is dispersed to spreadable grainless on coverslip；Finely dispersed Second addition is added
In the fusant of the first component obtained to step 1, it is dispersed with stirring；In the second skin conditioner that formula ratio is wherein added, stir
Dispersion is mixed, oily phase is obtained；
Step 3, formula ratio water intaking, glycerol, third skin conditioner and third additive, stirring point the preparation of water phase: are pressed
It dissipates, is heated to 40~50 DEG C and keeps the temperature, obtain the water phase of dissolved clarification；
Step 4, emulsion process: the water phase that step 3 is obtained is slowly added into the oily phase that step 2 obtains, and is dispersed with stirring simultaneously
Homogeneous to get；
Wherein, the first skin conditioner includes vaseline, white pond flower seed oil, dimethyl silicone polymer and tocopheryl acetate
Ester；The emulsifier includes cetyl PEG/PPG-10/1 dimethyl silicone polymer and the smooth isostearate of sorb,
The second skin conditioner includes bisabolol, N- palmityl hydroxy-proline cetyl, stearic acid, rape steroid
Alcohols and ginger-root extract；Second addition includes Nexbase 2004, -18 hectorite of quaternary ammonium salt, vinylpolydimethyl silicon oxygen
Alkane/polymethyl siloxane silsesquioxane cross-linked polymer and the second diluent；Second diluent include cyclohexasiloxane,
Cyclomethicone, ring five dimethyl silicone polymer, cyclotetrapolydimethylsiloxane and hexyl decyl alcohol；
The third skin conditioner include dipotassium glycyrrhizinate, hydroxyisoleucine, pot marigold seed oil, Sodium Hyaluronate and
Hydrolysed rice albumen；The third additive includes sodium chloride, polyethylene glycol and third diluent, and Sodium Hyaluronate includes Mr
For (1~2) × 106HA and Mr be (1~8) × 104HA；The third diluent includes butanediol and 1,2- hexylene glycol；
The formula of embodiment 1-5 is as shown in table 1-3.
Each ingredient and its parts by weight (unit: part) in the first component of 1 embodiment 1-5 of table
Each ingredient and its parts by weight (unit: part) in the second component of 2 embodiment 1-5 of table
Each ingredient and its parts by weight (unit: part) in the third component of 3 embodiment 1-5 of table
Embodiment 6-12: multi-functional frost, difference from Example 1 are, select and emulsify as shown in table 4 or table 5
Agent, Second addition and third additive.
Emulsifier, Second addition and the third additive information of 4 embodiment 6-9 of table
Emulsifier, Second addition and the third additive information of 5 embodiment 10-12 of table
Embodiment 13: multi-functional frost, difference from Example 1 are, are prepared by the following method: by formula ratio
Take all raw materials, be dispersed with stirring, be gradually heated to 65~75 DEG C and keep the temperature 1~2hr to get.
Comparative example
1. the preparation of control sample
(1) control sample 1: preparing with reference to embodiment 1 in CN105395465A, specifically: take 5 parts of glycerol, aloe essence
3 parts of liquid, 5 parts of green tea seed oil, 8 parts of pearl powder, 3 parts of vitamin e acetate, 2 parts of lecithin wax, 5 parts of candelila wax, the wooden fruit of refining cream
8 parts of oil, refined coconut oily 8 parts, vitamin B3 part, 1 part of stearoxyl trimethyl silane, 3 parts of hyaluronic acid, microstage walnut powder 5
Part, 5 parts of marine algae extract, 8 parts of molecular distillation monoglyceride, 10 parts of olive oil, 3 parts of arbutin, 3 parts of saualane, are uniformly dispersed, i.e.,
?.
(2) control sample 2-4: the commercially available multi-functional frost of 3 different brands is selected at random.
2. acute skin irritation test
(1) test specimen: respectively with the multi-functional frost of embodiment 1-13 preparation for test sample, control sample 1-4 is referring to sample
Compare test；
(2) it content of the test: is tested referring to " cosmetics health specification (2007) version " regulation, each test specimen is flat
The healthy albino guinea-pig of row selection 10 is tested, and test temperature and humidity is 20-25 DEG C/60-70RH%；About for 24 hours r before testing, will
Experimental animal back backbone two sides coat is cut, and unhairing range is respectively 2cm × 3cm, and application area is 2.5cm × 2.5cm；Take by
Examination object 0.1g is coated directly on skin, is covered, then fixed with nonirritant adhesive plaster, is applied with oilpaper and two layers of gauze after smearing
With 24 hours.Residual tested material is removed with warm water after the test.Observation in 1,24,48 and 72 hour is smeared after removing tested material
Area skin reaction carries out dermoreaction scoring by table 6, with the average value progress overall merit of animal subject integral, according to 24,
48 and 72 hours each observation time point top mean values, determine skin irritatin intensity by table 7.Oilpaper and two layers of gauze are covered,
Nonirritant adhesive plaster is used to be subject to fixed processing method as control again.
6 skin wound repair of table scoring reference standard
7 skin irritatin strength grading reference standard of table
| Integral mean value | Strength grading |
| 0- < 0.5 | It is nonirritant |
| 0.5- < 2.0 | Slight stimulation |
| 2.0- < 6.0 | Medium irritation |
| 6.0- < 8.0 | Strong and stimulating |
(3) test result: as shown in table 8, table 8 shows that the properties of samples of embodiment 1-13 is mild, skin acute irritation
Test result is nonirritant.
8 acute skin irritation test result of table
More than 3. skin irritatin test
(1) test specimen: respectively with the multi-functional frost of embodiment 1-13 preparation for test sample, control sample 1-4 is referring to sample
Compare test；
(2) it content of the test: is tested referring to " cosmetics health specification (2007) version " regulation, each test specimen is flat
The healthy albino guinea-pig of row selection 10 is tested, and test temperature and humidity is 20-25 DEG C/60-70RH%；About for 24 hours r before testing, will
Experimental animal back backbone two sides coat is cut, and unhairing range is respectively 2cm × 3cm, and application area is 2.5cm × 2.5cm；Take by
Examination object 0.1g is coated directly on skin, is covered after smearing with oilpaper and two layers of gauze, then fixed with nonirritant adhesive plaster, often
It smears primary, continuous 14 days smearings, smears the observation of the latter hour every time as a result, by the scoring of table 6, according to daily every animal
Average integral determines skin irritatin intensity by table 7.Cropping is answered before smearing every time, skin must not be damaged and guarantee tested material and skin
It comes into full contact with.Residual tested material is removed with warm water after the test.By oilpaper and the covering of two layers gauze, then with nonirritant adhesive plaster
It is subject to fixed processing method as control.
(3) test result: as shown in table 9, table 9 shows that the properties of samples of embodiment 1-13 is mild, multiple skin irritatin
Test result is nonirritant.
More than 9 skin irritatin test results of table
4. normal individual trial is tested
(1) test specimen: respectively with the multi-functional frost of embodiment 1-13 preparation for test sample, control sample 1-4 is referring to sample
Compare test；
(2) content of the test: each sample selects 100 babies to test in parallel at random；Subject washes one's face with conventional
After milk washes away foul on the face, using 0.5ml tested material, any other chemical product is not used during test.Respectively at 0 day, 7
It, 30 days and 180 days, observe the skin conditions of subject.Wherein, change of skin situation is with the skin at tested initial stage
For control.
(3) test result: as shown in table 10, table 10 shows that the properties of samples of embodiment 1-13 is mild, and normal individual trial is surveyed
It is compared in examination with control sample, the multi-functional frost of the application has better moisture retention, the flesh that can preferably protect baby tender
Skin.
10 normal individual trial test result of table
4. milk moss and/or the normal individual trial that is chapped from the cold test
(1) test specimen: respectively with the multi-functional frost of embodiment 1-13 preparation for test sample, control sample 1-4 is referring to sample
Compare test；
(2) content of the test: each sample selects the baby of 100 performance milk moss and/or clinical symptoms of being chapped from the cold in parallel at random
It is tested；Subject, using 0.5ml tested material, does not use after washing away foul on the face with conventional facial cleanser during test
Any other chemical product.Respectively at 0 day, 7 days and 30 days, the skin conditions of subject are observed.Wherein, change of skin situation is
It is control with the skin at tested initial stage.
(3) test result: as shown in table 11, table 11 shows that the properties of samples of embodiment 1-13 is mild, milk moss and/or
It is compared in the normal individual trial that is chapped from the cold test with control sample, the multi-functional frost of the application has preferably prevention and treatment milk moss and/or is chapped from the cold
Effect, can preferably safeguard the tender skin of baby.
11 milk moss of table and/or normal individual trial test result of being chapped from the cold
5. stability test
(1) test specimen: respectively with the multi-functional frost of embodiment 1-13 preparation for test sample, control sample 1-4 is referring to sample
Compare test；
(2) content of the test: being tested for each test specimen parallel 5 times, and each sample is placed following environment respectively
In: 0 DEG C/20%RH/ sealing, 20 DEG C/60%RH/ sealing and 40 DEG C/75%RH/ sealing；Respectively at 0 day, 30 days and 360 days into
Row test, test item include appearance and each component content test, wherein content measuring take face cream not with air contact portion.
(3) test result: test result and 0 day test result be compared, test result as shown in table 12-14,
Table 12-14 shows that the sample of embodiment 1-13 is stablized, and quality is controllable；Its its property in placement process of especially embodiment 1-5
Matter is substantially unchanged.
12 stability test result of table (0 DEG C/20%RH/ sealing)
13 stability test result of table (20 DEG C/60%RH/ sealing)
14 stability test result of table (40 DEG C/75%RH/ sealing)
Claims (4)
1. multi-functional frost, which is characterized in that including the first component, the second component and third component,
First component includes the first skin conditioner and emulsifier, and the first skin conditioner includes vaseline, Bai Chihua
Seed oil, dimethyl silicone polymer and tocopherol acetate；
Second component includes the second skin conditioner and Second addition, and the second skin conditioner includes opopanax
Alcohol, N- palmityl hydroxy-proline cetyl, stearic acid, campesterol class and ginger-root extract；
The third component includes water, glycerol, third skin conditioner and third additive, and the third skin conditioner includes
Dipotassium glycyrrhizinate, hydroxyisoleucine, pot marigold seed oil, Sodium Hyaluronate and hydrolysed rice albumen；
First component: the second component: the weight fraction ratio of third component is 1:1 ~ 1.5:5 ~ 20；
In first component, the weight fraction ratio of the first skin conditioner and emulsifier is 1:1.2 ~ 3,
First skin conditioner by the vaseline of 10 ~ 40wt%, the white pond flower seed oil of 20 ~ 30wt%, 20 ~ 30wt% poly dimethyl silicon
The tocopherol acetate of oxygen alkane and 20 ~ 30wt% composition；
The emulsifier is smooth by the cetyl PEG/PPG-10/1 dimethyl silicone polymer of 25 ~ 75wt% and the sorb of 25 ~ 75wt%
Isostearate is constituted；
In second component, the weight fraction ratio of the second skin conditioner and Second addition is 1:1.5 ~ 5；
The second skin conditioner is by the bisabolol of 20 ~ 40wt%, the N- palmityl hydroxy-proline spermaceti of 15 ~ 20wt%
Ester, the stearic acid of 15 ~ 20wt%, the campesterol class of 15 ~ 20wt% and 15 ~ 20wt% ginger-root extract constitute；
Second addition by the Nexbase 2004 of 10 ~ 30wt%, -18 hectorite of quaternary ammonium salt of 10 ~ 25wt%, 10 ~ 25wt% ethylene
The second diluent of base dimethyl silicone polymer/polymethyl siloxane silsesquioxane cross-linked polymer and 20 ~ 50wt% are constituted；
Second diluent is by the cyclohexasiloxane of 15 ~ 25wt%, the cyclomethicone of 15 ~ 25wt%, 15 ~ 25wt%
Ring five dimethyl silicone polymer, 15 ~ 25wt% cyclotetrapolydimethylsiloxane and 15 ~ 25wt% hexyl decyl alcohol constitute；
In third component, the water, glycerol, third skin conditioner and third additive weight fraction ratio be 1:0.5 ~ 0.6:
0.05 ~ 0.3:0.4 ~ 0.8；The third skin conditioner is different bright by dipotassium glycyrrhizinate, the hydroxyl of 15 ~ 25wt% of 15 ~ 25wt%
The hydrolysed rice albumen composition of propylhomoserin, the pot marigold seed oil of 15 ~ 25wt%, the Sodium Hyaluronate of 15 ~ 25wt% and 15 ~ 25wt%；
The third additive by the sodium chloride of 20 ~ 35wt%, the polyethylene glycol of 20 ~ 35wt% and 30 ~ 60wt% third diluent
It constitutes；
The third diluent is made of the 1,2- hexylene glycol of the butanediol of 25 ~ 75wt% and 25 ~ 75wt%.
2. multi-functional frost according to claim 1, which is characterized in that the Sodium Hyaluronate includes that Mr is (1 ~ 2) × 106
Sodium Hyaluronate and Mr be (1 ~ 8) × 104Sodium Hyaluronate.
3. multi-functional frost according to claim 1, which is characterized in that the multi-functional frost is prepared by the following method:
Step 1, the preparation of the first component fusant: the first skin conditioner and emulsifier are measured by formula, is dispersed with stirring, is heated
It to 55 ~ 68 DEG C and keeps the temperature, obtains the first component under finely dispersed molten condition；
Step 2, the preparation of oily phase: Second addition is measured by formula and is uniformly dispersed, the first component that step 1 obtains is added to
Fusant in, be dispersed with stirring；In the second skin conditioner that formula ratio is wherein added, it is dispersed with stirring, obtains oily phase；
Step 3, the preparation of water phase: formula ratio water intaking, glycerol, third skin conditioner and third additive are pressed, is dispersed with stirring, adds
Heat is to 40 ~ 50 DEG C and keeps the temperature, and obtains the water phase of dissolved clarification；
Step 4, emulsion process: the water phase that step 3 is obtained is slowly added into the oily phase that step 2 obtains, and is dispersed with stirring simultaneously homogeneous,
To obtain the final product.
4. multi-functional frost according to claim 3, which is characterized in that in the step 2, Second addition is finely dispersed
Degree are as follows: the Second addition after dispersion is dispersed to spreadable grainless on coverslip.
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| CN107811950B (en) * | 2017-12-06 | 2021-03-02 | 达威控股有限公司 | Hip-protecting cream with nursing effect on skin of baby and preparation method thereof |
| CN108272692A (en) * | 2018-04-10 | 2018-07-13 | 广东卡维达商务集团有限公司 | A kind of foster long-acting bi-component BB frosts and preparation method thereof for holding adornment of unification of adornment |
| CN108392438A (en) * | 2018-04-10 | 2018-08-14 | 广东卡维达商务集团有限公司 | A kind of moisturizing condensation and preparation method thereof, application |
| CN111544564B (en) * | 2020-04-29 | 2023-07-28 | 娇时日化（杭州）股份有限公司 | Ointment for treating infant diaper dermatitis and preparation method thereof |
| CN112494377A (en) * | 2020-09-22 | 2021-03-16 | 福建省梦娇兰日用化学品有限公司 | Infant repair cream containing rape-derived phytosterol and preparation method thereof |
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| CN105395465A (en) * | 2015-12-31 | 2016-03-16 | 周雷雷 | Moisture-retaining whitening face cream |
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