CN1057928C - Medicine for ulcer and its preparation - Google Patents

Abstract

The present invention relates to a traditional Chinese medical preparation for treating diseases such as canker, etc. and a preparation method thereof. The traditional Chinese medical preparation is composed of 10 to 50 portions of arnebia root, 2 to 10 portions of pearl, 10 to 50 portions of borneol and 100 to 1000 portions of vegetable oil by weight. First, the pearl is pulverized into fine powder; the arnebia root is moistened and is arranged into the vegetable oil to be heated to 90 to 125 DEG C; extraction can be carried out once or twice, and each time of the extraction lasts 0.5 to 2 hours; obtain materials are filtered; borneol is added into filter liquor and is melted in the filter liquor; pearl powder is added into the obtained materials and is uniformly mixed, and finished products are obtained. The traditional Chinese medical preparation of the present invention has the advantages of conspicuous curative effect, easy manufacture and convenient application.

Description

A kind of medicine for the treatment of ulcer and preparation method thereof

The present invention relates to a kind of medicine for the treatment of ulcer and preparation method thereof, be specially adapted to treat a kind of Chinese medicine preparation and preparation method thereof of the difficult wound healing mouth such as trauma infection contamination, skin infection, mucocutaneous ulcer, burn and scald of infections section illness.

At present, mainly adopt two kinds of methods for the skin diabrosis of infections section illness, the treatment of skin infection wound surface, a kind of is to carry out diagnosis and treatment with Western medicine, and a kind of is to carry out diagnosis and treatment with Chinese medicine.Mostly the setting of existing health care institutions at different levels and the talent's training are based on western medicine and medical practitioners, so often adopt oral or intramuscular injection or intravenous drip antibiotic, the part is deposited is treated with ethacridine etc.Select the problems such as Drug resistance of improper and antibacterial as antibiotic, then can make ulcer surface be difficult to control,, often slowly make wound surface be difficult to healing because of granulation tissue forms again just both bacterial infection was controlled.Particularly in the rural area during with doctor trained in Western medicine division of Western drugs reason infections section illness, normal for want of strict gnotobasis and necessary appointed condition and can not finely carry out the work, the means of handling sometimes can make slight skin injury cause severe infections.And adopt Chinese medicine is main body, changing dressings then is the main means of treatment infections section illness, used medicine mostly is traditional unguentum, powder, as Radix Et Rhizoma Rhei cream, Shengji Yuhong Gao, SHENGJISAN etc., though in clinical, use these preparations better curative effect is arranged, because of its drug distribution inequality, be difficult in the damaged tissue of infiltration, malabsorption disadvantage such as can not use to the treatment of deep wound, so the scope of application has tangible limitation.

Purpose of the present invention just provides a kind of medicine for the treatment of ulcer and preparation method thereof, and it cures mainly skin and mucosa traumatic infection, and ulcer, the prolonged diseases such as skin infection, carbuncle, burn and scald that do not heal are not only evident in efficacy, and preparation technology is simple, uses conveniently.

The object of the present invention is achieved like this: each material component weight proportion of this medicine is: Radix Arnebiae (Radix Lithospermi) 10-50 part, Margarita 2-10 part, Borneolum Syntheticum 10-50 part, vegetable oil 100-1000 part, also can add Radix Angelicae Sinensis 10-50 part according to the actual therapeutic needs, its preparation method is earlier that crushing pearl 120-200 purpose fine powder is standby, Radix Angelicae Sinensis, the wetted Radix Arnebiae (Radix Lithospermi) of water adds in the vegetable oil heats 90-125 ℃, extract once or twice, each extraction time 0.5-2 hour, extract for the first time, get 60% of vegetable oil full dose, after extracting filtration, filtering residue is immersed in reheat extraction filtration in the remaining vegetable oil, merge filtrate twice, add Borneolum Syntheticum then, make it fusing, be blended into the Margarita powder mixing, get product.

The present invention is on the basis of inheriting old docter of TCM's clinical experience, at the present Chinese and western drugs problem that treatment exists to infective wound surface, the drug effect evidence of the existing modern medicine of developing---antibacterial anti-inflammatory, reducing swelling and alleviating pain, promotion granulation tissue are grown, and logos foundation---the newtype drug of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the granulation promoting that gets rid of illness of theory of Chinese medical science is arranged again.This medicine cures mainly traumatic infection, skin and mucosal ulcer, prolonged skin infection, the burn and scald etc. of not healing.Skin infection is the surgery common disease, divide because of diseases caused by exogenous pathogenic factor or internal injury, wherein with " pyretic toxicity " or " fire-toxin " for seeing more, show as clinical more and pent up red because of pyretic toxicity; Meridians block, coagulation of QI-blood and swelling; Excessive noxious heat is warm then; The QI and blood swelling stagnates, blocking barrier, stagnation of QI and blood may bring about pain.Or intenseness of heat hollow heart ulcer then, it is controlled and works as heat-clearing and toxic substances removing, reducing swelling and alleviating pain, putrefaction-removing granulation-promoting.The first-selected sweet in the mouth alkalescence of this medicine is cold, and the key medicine Radix Arnebiae (Radix Lithospermi) of " promoting blood circulation and cooling blood " is a monarch drug.This medicine work of concentrating one's efforts does not hard outward all have by means of its removing pathogenic heat from blood and toxic substance from the body in Compendium of Material Medica, " Lu ", and the disappear merit of pain of invigorating blood circulation is contained the record of carbuncle skin infection to control the heat in blood poison.At the pathomechanism of plant sore, clinical change characteristics, its purpose are changed congestion detumescence pain in heat clearing away poison, removing heat from blood heat.Margarita is a ministerial drug in the side.Get its sweet in the mouth and become cold property, the merit of using that can obtain " poison that unhitches, change malignant boil, receive the internal ulceration junk " is so can cure mainly all malicious cellulitis skin ulcers, wear the routed network of muscle, pus and blood is dripping, the disease that ulcer is not received.So auxilliary monarch drug, to increase heat-clearing and toxic substances removing, the effect of the pain granulation promoting that disappears.Also can add the hot sweet using warming therapy Radix Angelicae Sinensis of enlisting in the side, this medicine can " broken stagnant blood, foster fresh blood ", " granulation promoting meat ".Increase the drug effect of monarch, ministerial drug, help the invigorate blood circulation power of putrefaction-removing granulation-promoting of all medicines of the monarch and his subjects, cross cold fraud with all medicines of its hot using warming therapy assistant system the monarch and his subjects.The present invention selects Borneolum Syntheticum for use, gets the property of its " hot with eliminating stagnation, bitter cold is purged heat, the kind fire stagnation that looses ", can receive the merit of " granulation promoting pain relieving ", and power that again can its saturating key is drawn the through sick institute of all medicines, with the performance drug effect.The sweet cold of Oleum Sesami nature and flavor has the effect of moistening dryness for relaxing bowels, scattered inflammatory swelling and granulation promoting.Its skin of both can having moistened, the blocking external irritant, the protection skin surface has the effect of softening crust, cleaning wound surface again.All medicines share the effect of common receipts heat-clearing and toxic substances removing, reducing swelling and alleviating pain, antibacterial anti-inflammatory, putrefaction-removing granulation-promoting, the growth of promotion granulation tissue.This medication is imitated significantly, makes easily, uses conveniently.

This medicine carries out animal experiment through units such as preclinical medicine institute of Chinese Medical Sciences University, medical biotechnology institutes to its pharmacology, drug effect, toxic and side effects etc., and its result is as follows:

One, bacteriostatic test

Adopt Muller-llinton agar plate and blood agar plating medium place aseptic mould firmly to encircle in cup, add the method that is subjected to the reagent thing, result of the test sees Table 1.

Table 1 is tried thing and is tried concentration test number (TN) test strain

(extension rate)

Staphylococcus aureus beta hemolytic streptococcus colon bacillus Pseudomonas aeruginosa

The tested medicine stock solution 18 100 94 94 100 of the antibacterial positive rate of the antibacterial positive rate of the antibacterial positive rate of antibacterial positive rate (%) (%) (%) (%)

2 times 18 94 94 100 94

4 times 18 94 100 94 100

40 times 18 100 100 94 94

400 times of 18 94 94 100 94 positive drug penicillin 500 μ g/ml 18 100 100

250μg/ml 18 100 100

125 μ g/ml, 18 100 100 sulphuric acid are celebrated 500 μ g/ml, 18 100 100 big mycin 250 μ g/ml 18 100 100

125 μ g/ml, 18 100 100 negative control thing sesame oil, 18 000 0DHSO+ Tween-80s, 18 0000 physiological saline 18 0000

Conclusion (of pressure testing): this medicine is to G ⁽⁺⁾Coccus: golden yellow Fructus Vitis viniferae pearl bacterium and G ^(-)Bacillus: B-mode (β) Hemolytic streptococcus, colon bacillus and Pseudomonas aeruginosa have stronger inhibitory action.

Two, Oleum Tiglii is brought out the influence of mice ear inflammation

Select 60 of healthy mices, body weight 18-20g, ♂ ♀ half and half is divided into 5 groups at random, and 12 every group, bring out mice ear edema with Oleum Tiglii, be coated with medicament of the present invention, hydrocortisone ointment, Oleum Sesami, normal saline then, it the results are shown in Table 2.

Table 2

Group number of animals dosage ear swelling weight suppression ratio P

(only) (mg/kg) (X ± SDmg) (%) and saline than and the Oleum Sesami ratio

Normal saline 12 capacity such as grade 16.32 ± 2.70---

Oleum Sesami 12 capacity such as grade 10.32 ± 2.58 36.76＜0.001-

Hydrocortisone 12 25 8.85 ± 2.90 45.77＜0.001＞0.05

This medicine low dose of 12 50 12.09 ± 5.30 25.91＜0.001＞0.05

This medicine heavy dose of 12 250 6.06 ± 2.76 62.87＜0.001＜0.001

Conclusion (of pressure testing): this medicine brings out mice ear inflammation to Oleum Tiglii therapeutical effect.

Three, to the influence of the damaging non-infectious wound healing of Cavia porcellus

Select 60 of albino guinea-pigs, body weight 266 ± 32g, ♂ ♀ half and half, be divided into 5 groups at random by body weight and sex, 12 every group, lose hair or feathers in spinal column both sides, back, cut a circular incision, after 24 hours, the beginning administration, with dosage be respectively 40,200mg/kg medicament of the present invention and normal saline, Oleum Sesami, libano medicine hinder the face administration for respectively 5 groups of Cavia porcelluss, once a day, observe the wound healing situation, each group is many to heal in 5-7 days, and its wound dwindles percent relatively as table 3.

Before the routine number administration of table 3 group (mg/kg) after the administration minification (%) and YD high dose group relatively (%) physiological saline 12 7.7 ± 0.6 2.7 ± 1.5 65.2-19.4 sesame oil 12 8.0 ± 2.0 2.4 ± 2.1 69.6-15.0 libano 2 12 8.3 ± 1.5 2.2 ± 1.9 73.9-10.7 low dose of 40 12 8.0 ± 1.5 2.0 ± 1.9 75.0-9.6 heavy dose of 200 12 7.8 ± 1.3 1.2 ± 1.3 84.6*-

Numerical value is X ± SDmm in the table; * P＜0.05 (with Oleum Sesami or normal saline comparison)

Conclusion (of pressure testing); This medicine has the healing of promotion effect to the damaging non-skin infection wound surface of Cavia porcellus.

Four, observe the analgesic activity of this medicine with hot plate method to mice

Select 56 of Healthy female mices, body weight 18-21g is divided into 4 groups at random, and 14 every group, difference gastric infusion (0.5ml/kg); The large and small dosage of this medicine, bucinnazine, Oleum Sesami.Every day 2 times, continuous 2 days, and, survey the threshold of pain time respectively, its result such as table 4 in last administration before and after 1,1.5,2 hour.

Before the table 4 group dosage number of animals medicine with medicine after different hours threshold of pain time differences (second)

(g/kg) 1 1.5 2 contrasts are with low dose of 1.250 14 1.1 ± 3.4 10.8 ± 6.9 9.1 ± 8.8 heavy dose of 2.500 14 15.0 ± 4.6** 19.2 ± 7.8 25.8 ± 7.8, volume 14-1.4 ± 1.1 7.5 ± 8.2 7.0 ± 7.3 bucinnazine, 0.009 14 17.2 ± 4.3** 16.2 ± 5.0 18.4 ± 5.1

Numerical value is X ± SDmm in the table; * P＜0.01 (comparing) with matched group

Conclusion (of pressure testing); This medicine has certain prevention and inhibitory action to the chmice acute burning pain.

Five, animal acute toxicity test

(1), maximum tolerance determination:

Select 40 of healthy mices, fasting was divided into two groups at random by sex after 8 hours, and (maximum volume is 1ml/20g to pour into this medicine 20g/kg to gastric respectively; Cmax is 0.4g/ml), 2000 times of quite clinical people's ampoule 0.6g/60kg), observe the toxic reaction in 7 days after the administration.

Select 40 of healthy mices, be divided into two groups at random, inject this medicine 10g/kg (0.5ml/20g is equivalent to 1000 times of clinical people's ampoule) respectively through the abdominal cavity, observe the toxic reaction in 7 days behind the single administration by sex.

Behind two kinds of administrations, feed of mice outward appearance and activity etc. are all normal, do not see the overt toxicity reaction.

Conclusion (of pressure testing), the maximum tolerated dose of this medicine per os and intraperitoneal administration is greater than 10g/kg.

(2), skin acute toxicity test:

Select 12 of albino guinea-pigs, be divided into 3 groups at random, right side, back unhairing, be coated with Oleum Sesami after 24 hours respectively, this medicine low dose (concentration 100% clinical practice concentration), heavy dose of group (concentration 400%), each 1ml, every day 3 times, in 14 days to Cavia porcellus intact skin non-toxic reaction, in back part of animal right side unhairing, and scratch skin, immediately at damaged position coating with blade, and with matched group relatively, the behavior of Cavia porcellus in 14 days, activity, diet, fur gloss and body weight have no effect, and do not have dead and any acute toxic reaction.

Conclusion (of pressure testing): this medicine is used for the complete sum damaged skin under 100% (clinical practice concentration) and 400% concentration, Cavia porcellus is not all caused acute toxic reaction.

Six, long-term toxicity test for animals

Select 60 of rats, be divided into 3 groups (20 every group) at random by sex and body weight, the back depilation is coated with Oleum Sesami respectively, this medicine low dose 100% (clinical practice concentration), heavy dose of 400%, 1ml/ time, 3 times/day, continuous 30 days, the conventional raising, observe the general performance of rat, the variation of record, body weight, hemogram, liver, renal function and histological examination, its result is shown in table 5,6,7.

The situation of change of table 5 body weight (X ± SDg)

Week 01234

Heavy dose of 226 ± 23 258 ± 33 280 ± 57 290 ± 59 310 ± 50

Low dose of 210 ± 21 244 ± 31 278 ± 60 289 ± 59 300 ± 57

Oleum Sesami group 222 ± 27 258 ± 40 281 ± 45 294 ± 42 311 ± 56

The influence of table 6 pair hemogram (the neutral pillar cells lymphocyte of the group RBC number hemoglobin reticulated red blood cells leukocyte count of X ± SDg) platelet

(* 10 °/L), (g/L), (* 10 °/L), (* 10 °/L), (* 10 °/L) heavy dose of 5.23 ± 0.45 155 ± 13 0.012 ± 0.011 9.70 ± 2.17 0.16 ± 0.08 0.84 ± 0.08 0.39 ± 0.14 low doses 5.03 ± 0.35 154 ± 14 0.012 ± 0.011 9.60 ± 2.27 0.17 ± 0.05 0.81 ± 0.08 0.39 ± 0.12 sesame oil group 5.33 ± 0.29 157 ± 9 0.005 ± 0.003 9.12 ± 3.34 0.13 ± 0.06 0.86 ± 0.06 0.38 ± 0.11

The influence of table 7 pair liver function and kidney merit (X ± SDg)

Group glutamate pyruvate transaminase carbamide ammonia

(nmol·Sl/L) (mmol/L)

Heavy dose of 327 ± 59 6.75 ± 1.65

Low dose of 315 ± 63 6.86 ± 1.12

Oleum Sesami group 303 ± 109 6.13 ± 1.11

Conclusion (of pressure testing): this medicine 100% concentration (clinical practice concentration), continuous 30 days skin coatings of 400% concentration, rat body weight growth, hemogram, liver function, renal function and matched group are not relatively had obvious influence, the heart, liver, spleen, lung, kidney, adrenal gland, lymph node, testis, ovary and skin histology structure are not had influence.

Skin anaphylactic test:

20 of albino guinea-pigs, body weight 365 ± 19g is divided into three groups, 10 every group, male and female half and half are coated with Oleum Sesami respectively, this medicine 100% (clinical concentration), positive control DNFB after the depilation of back, later every interval was coated with once in 7 days, and it is coated with secondary, and observed result after 14 days is as shown in table 8.

Table 8

Grouping number of animals erythema integration edema integration highest point total value sensitization incidence rate (%)

This medicine group 10 0.1 ± 0.3 0 0.1 ± 0.3 10

Oleum Sesami group 10 0.1 ± 0.3 0 0.1 ± 0.3 10

DNFB organizes 10 3.6 ± 0.5 2.6 ± 0.5 6.2 ± 1.0 100

Conclusion (of pressure testing): this medicine external does not have skin allergy to Cavia porcellus.

These medicinal treatment traumatic infection 1260 routine clinical observation result:

Treat unit through provincial hospital; No.1 Clinical College, China Medical Univ., Hospital Attached to Liaoning Inst. of Traditional Chinese Medicine; City-level is treated the doctor unit; Shenyang 242 hospitals, city women and infants hospital etc. carry out clinical observation to 1260 routine patients.Man's 752 examples, women 508 examples, minimal ages three months, maximum 82 years old age, the course of disease 15 days-1 year, method, the conventional debridement, disinfection of wound surface, abscess is cut in good time, sinus tract is scraped fistula, removes dense sexual secretion and slough, and the sterile gauze that is soaked with this medicine oil preparation is spread on wound surface, add a cover the dressing wrapping, or direct coating is in affected part.Every day or the next day change dressings 1 time, two weeks were a course of treatment.Observed result: through a course of therapy, in 1260 examples, 1215 example recoveries from illness, produce effects 31 examples, the recovery from illness obvious effective rate is 98.9%, and the clinical meaning of highly significant is arranged.

In sum, this medicine has determined curative effect, safe without toxic side effect, widely applicable advantage through a large amount of tests and clinical proof.

The invention will be further described below in conjunction with embodiment.

Embodiment 1

Take by weighing 20 kilograms of Radix Arnebiae (Radix Lithospermi)s, 10 kilograms of Margaritas, 20 kilograms of Borneolum Syntheticums, 600 kilograms in Oleum Glycines respectively, earlier Margarita powder is broken into 120-200 order fine powder, standby, the wetted Radix Arnebiae (Radix Lithospermi) of water is put into 360 kilograms of Oleum Glycines, be heated to 90 ℃, continue 2 hours, filter, filtering residue is immersed in the remaining Oleum Glycines, be heated to 100 ℃, extracted 1 hour, and filtered, merge filtrate twice, put into Borneolum Syntheticum then and make it fusing, be blended into the Margarita fine powder, mixing, packing gets product.The outstanding poison that unhitches of this medicine, change malignant boil, receipts internal ulceration, the merit of junk has produce effects to carbuncle.

Embodiment 2

Take by weighing 10 kilograms of Radix Arnebiae (Radix Lithospermi)s, 2 kilograms of Margaritas, 15 kilograms of Borneolum Syntheticums, 1000 kilograms in Oleum Sesami respectively, earlier Margarita powder is broken into 120-200 order fine powder, wetted Radix Arnebiae (Radix Lithospermi) is added in 600 kilograms of Oleum Sesami, be heated to 100 ℃, extracted 1 hour, filter, filtering residue immerses in the remaining Oleum Sesami again, carries out second extraction, is heated to 100 ℃, extract half an hour, filter, twice filtrate is merged, add Borneolum Syntheticum and make it fusing, be blended into Margarita powder, mixing gets product.This medicine all has produce effects to acute and chronic traumatic infection, ulcer.

Embodiment 3

Take by weighing 50 kilograms of Radix Arnebiae (Radix Lithospermi)s, 10 kilograms of Margaritas, 50 kilograms of Borneolum Syntheticums, 1000 kilograms of Oleum Arachidis hypogaeae semen respectively, earlier Margarita powder is broken into 120-200 order fine powder, wetted Radix Arnebiae (Radix Lithospermi) is added in 600 kilograms of Oleum Arachidis hypogaeae semen, is heated to 125 ℃, extracted 1 hour, filter, Borneolum Syntheticum is put into filtrate, make it fusing, be blended into Margarita powder again, mixing gets product.This medicine analgesic effect is obvious, is suitable for to swell and ache acute stage.

Embodiment 4

Take by weighing 20 kilograms of Radix Arnebiae (Radix Lithospermi)s, 3 kilograms of Margaritas, 20 kilograms of Borneolum Syntheticums, 100 kilograms of Oleum Brassicae campestriss respectively, earlier Margarita powder is broken into 120-200 order fine powder, wetted Radix Arnebiae (Radix Lithospermi) added be put in the Oleum Brassicae campestris, be heated to 110 ℃, extracted 1 hour, filter, Borneolum Syntheticum is put into filtrate, make it fusing, be blended into Margarita powder again, mixing gets product.The outstanding poison that unhitches of this medicine, change malignant boil have produce effects to carbuncle.

Embodiment 5

Take by weighing 40 kilograms of Radix Arnebiae (Radix Lithospermi)s, 5 kilograms of Margaritas, 10 kilograms of Borneolum Syntheticums, 500 kilograms in Oleum Sesami respectively, earlier that crushing pearl 120-200 order fine powder is standby, the wetted Radix Arnebiae (Radix Lithospermi) of water is put into 300 kilograms of Oleum Sesami, be heated to 120 ℃, extract half an hour, filter, filtering residue is immersed in the remaining Oleum Sesami, is heated to 120 ℃, extracts half an hour, filter, merge extracted twice liquid, put into Borneolum Syntheticum and make it fusing, be blended into Margarita powder again, mixing gets product.This medicine is outstanding invigorates blood circulation, removing heat from blood, heat-clearing and toxic substances removing, evident in efficacy to the acute HIV infection wound surface.

Embodiment 6

Take by weighing 20 kilograms of Radix Arnebiae (Radix Lithospermi)s, 4 kilograms of Margaritas, 20 kilograms of Borneolum Syntheticums, 20 kilograms of Radix Angelicae Sinensis, 300 kilograms in Oleum Glycines respectively, it is standby earlier Margarita powder to be broken into 120-200 order fine powder, and Radix Arnebiae (Radix Lithospermi) is together added in 180 kilograms of Oleum Glycines with water-soaked and Radix Angelicae Sinensis, be heated to 95 ℃, extracted 1.5 hours, and filtered, filtering residue immerses in the remaining Oleum Glycines and is heated to 110 ℃, extracted 1.5 hours, filter, twice filtrate merges the adding Borneolum Syntheticum makes it fusing, is blended into Margarita powder again, mixing is finished product.This medicine heat-clearing and toxic substances removing, better to sinus tract, ulcus cruris effect, further improve the more treatment of wound surface of bursting for a long time.

Embodiment 7

Get 10 kilograms of Radix Arnebiae (Radix Lithospermi)s, 2 kilograms of Margaritas, 40 kilograms of Radix Angelicae Sinensis, 15 kilograms of Borneolum Syntheticums, 1000 kilograms in Oleum Sesami, earlier Margarita powder is broken into 120-200 order fine powder, Radix Arnebiae (Radix Lithospermi) is put into 600 kilograms of Oleum Sesami with water-soaked and Radix Angelicae Sinensis, be heated to 100 ℃, 1 hour, filter, filtering residue immerses in the remaining Oleum Sesami, be heated to 100 ℃, 0.5 hour, filter, merge twice filtrate adding Borneolum Syntheticum and make it fusing, be blended into the Margarita fine powder, mixing is finished product.

Embodiment 8

Get 40 kilograms of Radix Arnebiae (Radix Lithospermi)s, 10 kilograms of Margaritas, 10 kilograms of Radix Angelicae Sinensis, 50 kilograms of Borneolum Syntheticums, 800 kilograms of Oleum Arachidis hypogaeae semen, earlier Margarita powder is broken into 120-200 order fine powder, Radix Arnebiae (Radix Lithospermi) adds in the Oleum Arachidis hypogaeae semen with water-soaked and Radix Angelicae Sinensis once extracts, heat 100 ℃, 1.5 hours, filter, add Borneolum Syntheticum in the filtrate, make it fusing, be blended into Margarita powder, mixing.This medicine reducing swelling and alleviating pain, to acute stage the traumatic infection curative effect obvious.

Embodiment 9

Get 10 kilograms of Radix Arnebiae (Radix Lithospermi)s, 3 kilograms of Margaritas, 10 kilograms of Radix Angelicae Sinensis, 10 kilograms of Borneolum Syntheticums, 600 kilograms of Oleum Brassicae campestriss, Margarita is worn into fine powder, and wetted Radix Arnebiae (Radix Lithospermi) of water and Radix Angelicae Sinensis are put into oil, is heated to 95 ℃, 2 hours, filter, add Borneolum Syntheticum in the filtrate and make it fusing, be blended into Margarita powder, once extract mixing.This medicine is obvious to sinus tract, ulcus cruris therapeutic effect.

Embodiment 10

Get 30 kilograms of Radix Arnebiae (Radix Lithospermi)s, 10 kilograms of Margaritas, 25 kilograms of Radix Angelicae Sinensis, 10 kilograms of Borneolum Syntheticums, 300 kilograms in Oleum Sesami, at first Margarita is worn into fine powder, and wetted Radix Arnebiae (Radix Lithospermi) of water and Radix Angelicae Sinensis are put into Oleum Sesami, be heated to 100 ℃, 1 hour, filter, add Borneolum Syntheticum in the filtrate and make it fusing, be blended into the Margarita fine powder, mixing.

Show that through clinical practice this medicine is made solvent with Oleum Sesami, so lipotropy, permeability is good, is easy to be penetrated in the damaged tissue go, to heighten the effect of a treatment.In addition, this medical instrument has good mobility, can be evenly distributed on the whole wound surface, particularly the deep wound is more demonstrated superiority, is that unguentum, ointment or powder are incomparable.With the sticking wound surface of the impregnated pharmaceutical gauze of this medicine, patient's no pain when changing dressings, more superior is, the secretions of wound surface can be adsorbed onto on the gauze, makes wound surface keep pure and fresh, helps wound healing, also be water preparation can't be obtained.

Claims (4)

1, a kind of Chinese medicine preparation for the treatment of ulcer is characterized in that being made by the following weight proportion raw material, wherein: Radix Arnebiae (Radix Lithospermi) 10-50 part, Margarita powder 2-10 part, Borneolum Syntheticum 10-50 part and vegetable oil 100-1000 part.

2, a kind of Chinese medicine preparation of controlling ulcer is characterized in that being made by the following weight proportion raw material, wherein: Radix Arnebiae (Radix Lithospermi) 10-50 part, Margarita powder 2-10 part, Borneolum Syntheticum 10-50 part, Radix Angelicae Sinensis 10-50 part and vegetable oil 100-1000 part.

3, the preparation method of claim 1 and 2 described Chinese medicine preparation is characterized in that vegetable oil can be Oleum Sesami, Oleum Glycines, Oleum Arachidis hypogaeae semen, Oleum Brassicae campestris, preferentially select Oleum Sesami for use.

4, the preparation method of the described Chinese medicine preparation of claim 1, it is characterized in that pressing column weight amount proportioning and take by weighing each component: Radix Arnebiae (Radix Lithospermi) 10-50 part, Margarita 2-10 part, Borneolum Syntheticum 10-50 part, vegetable oil 100-1000 part, earlier that crushing pearl 120-200 order fine powder is standby, Radix Arnebiae (Radix Lithospermi) is put heating 90-125 degree in the vegetable oil into water-soaked, second extraction each extraction time 0.5-2 hour, is extracted each time, get 60% of vegetable oil full dose, after extracting filtration, filtering residue is immersed in reheat extraction filtration in the remaining vegetable oil, merges filtrate twice, add Borneolum Syntheticum then and make it fusing, be blended into Margarita powder, mixing gets product.