CN105770973A - 一种医用褥疮生物敷料的制备方法 - Google Patents

一种医用褥疮生物敷料的制备方法 Download PDF

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CN105770973A
CN105770973A CN201610140642.0A CN201610140642A CN105770973A CN 105770973 A CN105770973 A CN 105770973A CN 201610140642 A CN201610140642 A CN 201610140642A CN 105770973 A CN105770973 A CN 105770973A
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李苏扬
李文遐
徐勤霞
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Suzhou Bec Biological Technology Co Ltd
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Abstract

本发明公开了一种医用褥疮生物敷料的制备方法，该制备方法先按重量份计，称取各原料置于反应器中搅拌均匀后，并加热；然后将加热后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。通过本发明的方法制备的生物敷料采用中药配方，刺激性小，无毒副作用，不易复发，具有生物相容性好。抗菌消炎止血效果好，水率高、扯断和撕裂强度好、阻止渗液溢出，促进肉芽组织和上皮组织的形成，皮肤组织愈合和修复快，对褥疮引起的出血、肿胀、疼痛等均有很好的疗效。

Description

一种医用褥疮生物敷料的制备方法
技术领域
本发明属于医用生物新材料领域，涉及一种医用褥疮生物敷料的制备方法。
技术背景
褥疮又称压迫性溃疡或压疮，是内科常见的并发症之一，是由于神经及血液循环障碍、局部组织持续缺血、营养不良而发生的软组织坏死，其发生是机体受内因和外因共同作用引起的复杂病理过程，是一种十分难治的疾病，一旦发生，疗程长，易复发，可造成从表皮到皮下组织、肌肉，甚至骨与关节的破坏，给患者带来极大的痛苦，严重者可继发感染，引起败血症而导致死亡。我国人口众多，卧床病人多，褥疮发病率也一直处于高数值。对于褥疮治疗，国内外都做了大量研究工作，但至今为止，仍然没有找到非常有效的治疗及护理的药物和方法。由于在如下的一系列疾病患者中，包括Ⅰ、Ⅱ、Ⅲ和Ⅳ期糖尿病患者、脑损伤后引起昏迷、半身不遂、偏瘫或截瘫患者、颈椎骨折脱位合并截瘫患者、胸椎骨折脱位合并截瘫、腰椎爆裂骨折合并截瘫患者、骨质疏松引起骨折患者、晚期肿瘤患者及其他患病治疗中较长期卧床的患者等，都有大量出现并发褥疮情况，因此,褥疮的预防治疗以及护理成为一项艰巨而重要的工作,也是护理工作中长期存在而未完全解决的一大难题。
目前，临床上治疗褥疮常用的方法包括手术治疗方法，药物治疗方法和外敷方法。手术治疗主要是采用彻底清创后皮瓣转移修复，但该方法对于许多病人并不适合；药物疗法，包括内服药和外用药，也普遍存在效果不够明显的缺点。由于外敷方法简单易操作，且对病人的伤害最小，因此，许多临床研究也给以极大关注。传统创伤敷料包括棉纱绷带、绷带/卷装绷带、专用敷料、浸渍棉纱、豁合条带制品以及应急处理敷料杂品等，主要体现止血、防菌、防止伤口粘连和简单的包扎功能。显然，传统创伤敷料在褥疮治疗中无法满足要求。
生物敷料是在Winter等提出的创伤修复“湿润愈合”理论基础上发展起来的新型创面修复及保护材料。与传统敷料相比，生物敷料具有降低感染、提高创面愈合质量、减轻病人的痛苦以及方便医护人员操作等优点，因此得到了人们的青睐。目前，我国市场具有自主知识产权的并用于褥疮修复的敷料还很少，几乎是空白。因此，研究新型的用于褥疮修复的敷料与制备方法，具有极其重要的意义。
发明内容
本发明的目的在于针对现有技术的不足，提供一种医用褥疮生物敷料的制备方法。
本发明的目的是通过以下技术方案实现的：一种医用褥疮生物敷料的制备方法，该制备方法包括以下步骤：按重量份计，称取医用明胶40-50份、壳聚糖30-40份、风藤草粉8-13份、浮萍粉8-14份、海藻酸盐7-12份、刺蒺藜粉8-14份、白鲜皮粉9-12份、蒲公英粉8-12份、甘草酸二钾6-10份、透明质酸钠10-14份、川芎粉3-10份、乳化剂11-17份和水30-40份置于反应器中搅拌均匀后，加热到55~70℃，加热时间为15~25min；将加热后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
所述基布层为无纺布或PU防水透气膜。
所述粘结剂为压敏胶。
所述海藻酸盐为海藻酸钾、海藻酸钠或海藻酸钙。
所述乳化剂为硬脂酸单甘油脂或十二烷基硫酸钠。
本发明具有以下有益效果：通过本发明的方法制备的生物敷料采用中药配方，刺激性小，无毒副作用，不易复发，具有生物相容性好。抗菌消炎止血效果好，水率高、扯断和撕裂强度好、阻止渗液溢出，促进肉芽组织和上皮组织的形成，皮肤组织愈合和修复快，对褥疮引起的出血、肿胀、疼痛等均有很好的疗效。
具体实施方式
实施例1
一种医用褥疮生物敷料的制备方法，该制备方法包括以下步骤：按重量份计，称取医用明胶40份、壳聚糖30份、风藤草粉8份、浮萍粉8份、海藻酸盐7份、刺蒺藜粉8份、白鲜皮粉9份、蒲公英粉8份、甘草酸二钾6份、透明质酸钠10份、川芎粉3份、乳化剂11份和水30份置于反应器中搅拌均匀后，加热到55~70℃，加热时间为15~25min；将加热后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
所述基布层为无纺布或PU防水透气膜。
所述粘结剂为压敏胶。
所述海藻酸盐为海藻酸钾、海藻酸钠或海藻酸钙。
所述乳化剂为硬脂酸单甘油脂或十二烷基硫酸钠。
实施例2
一种医用褥疮生物敷料的制备方法，该制备方法包括以下步骤：按重量份计，称取医用明胶50份、壳聚糖40份、风藤草粉13份、浮萍粉14份、海藻酸盐12份、刺蒺藜粉14份、白鲜皮粉12份、蒲公英粉12份、甘草酸二钾10份、透明质酸钠14份、川芎粉10份、乳化剂17份和水40份置于反应器中搅拌均匀后，加热到55~70℃，加热时间为15~25min；将加热后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
所述基布层为无纺布或PU防水透气膜。
所述粘结剂为压敏胶。
所述海藻酸盐为海藻酸钾、海藻酸钠或海藻酸钙。
所述乳化剂为硬脂酸单甘油脂或十二烷基硫酸钠。
实施例3
一种医用褥疮生物敷料的制备方法，该制备方法包括以下步骤：按重量份计，称取医用明胶45份、壳聚糖35份、风藤草粉11份、浮萍粉11份、海藻酸盐11份、刺蒺藜粉12份、白鲜皮粉11份、蒲公英粉11份、甘草酸二钾8份、透明质酸钠12份、川芎粉6份、乳化剂14份和水35份置于反应器中搅拌均匀后，加热到55~70℃，加热时间为15~25min；将加热后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
所述基布层为无纺布或PU防水透气膜。
所述粘结剂为压敏胶。
所述海藻酸盐为海藻酸钾、海藻酸钠或海藻酸钙。
所述乳化剂为硬脂酸单甘油脂或十二烷基硫酸钠。

Claims (5)

1.一种医用褥疮生物敷料的制备方法，其特征在于该制备方法包括以下步骤：按重量份计，称取医用明胶40-50份、壳聚糖30-40份、风藤草粉8-13份、浮萍粉8-14份、海藻酸盐7-12份、刺蒺藜粉8-14份、白鲜皮粉9-12份、蒲公英粉8-12份、甘草酸二钾6-10份、透明质酸钠10-14份、川芎粉3-10份、乳化剂11-17份和水30-40份置于反应器中搅拌均匀后，加热到55~70℃，加热时间为15~25min；将加热后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
2.根据权利要求1所述一种医用褥疮生物敷料的制备方法，其特征在于：所述基布层为无纺布或PU防水透气膜。
3.根据权利要求1所述一种医用褥疮生物敷料的制备方法，其特征在于：所述粘结剂为压敏胶。
4.根据权利要求1所述一种医用褥疮生物敷料的制备方法，其特征在于：所述海藻酸盐为海藻酸钾、海藻酸钠或海藻酸钙。
5.根据权利要求1所述一种医用褥疮生物敷料的制备方法，其特征在于：所述乳化剂为硬脂酸单甘油脂或十二烷基硫酸钠。
CN201610140642.0A 2016-03-14 2016-03-14 一种医用褥疮生物敷料的制备方法 Pending CN105770973A (zh)

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