CN105688259A - 一种治疗褥疮生物敷料的制备方法 - Google Patents

一种治疗褥疮生物敷料的制备方法 Download PDF

Info

Publication number
CN105688259A
CN105688259A CN201610140668.5A CN201610140668A CN105688259A CN 105688259 A CN105688259 A CN 105688259A CN 201610140668 A CN201610140668 A CN 201610140668A CN 105688259 A CN105688259 A CN 105688259A
Authority
CN
China
Prior art keywords
preparation
powder
biological dressing
alginate
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610140668.5A
Other languages
English (en)
Inventor
李苏扬
李文遐
徐勤霞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suzhou Bec Biological Technology Co Ltd
Original Assignee
Suzhou Bec Biological Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suzhou Bec Biological Technology Co Ltd filed Critical Suzhou Bec Biological Technology Co Ltd
Priority to CN201610140668.5A priority Critical patent/CN105688259A/zh
Publication of CN105688259A publication Critical patent/CN105688259A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

本发明公开了一种治疗褥疮生物敷料的制备方法，该制备方法先按重量份计，称取各原料置于反应器中，超声高速分散；然后将分散后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。通过本发明的方法制备的生物敷料采用中药配方，刺激性小，无毒副作用，不易复发，具有生物相容性好。抗菌消炎止血效果好，水率高、扯断和撕裂强度好、阻止渗液溢出，促进肉芽组织和上皮组织的形成，皮肤组织愈合和修复快，对褥疮引起的出血、肿胀、疼痛等均有很好的疗效。

Description

一种治疗褥疮生物敷料的制备方法
技术领域
本发明属于医用生物新材料领域，涉及一种治疗褥疮生物敷料的制备方法。
技术背景
褥疮又称压迫性溃疡或压疮，是内科常见的并发症之一，是由于神经及血液循环障碍、局部组织持续缺血、营养不良而发生的软组织坏死，其发生是机体受内因和外因共同作用引起的复杂病理过程，是一种十分难治的疾病，一旦发生，疗程长，易复发，可造成从表皮到皮下组织、肌肉，甚至骨与关节的破坏，给患者带来极大的痛苦，严重者可继发感染，引起败血症而导致死亡。我国人口众多，卧床病人多，褥疮发病率也一直处于高数值。对于褥疮治疗，国内外都做了大量研究工作，但至今为止，仍然没有找到非常有效的治疗及护理的药物和方法。由于在如下的一系列疾病患者中，包括Ⅰ、Ⅱ、Ⅲ和Ⅳ期糖尿病患者、脑损伤后引起昏迷、半身不遂、偏瘫或截瘫患者、颈椎骨折脱位合并截瘫患者、胸椎骨折脱位合并截瘫、腰椎爆裂骨折合并截瘫患者、骨质疏松引起骨折患者、晚期肿瘤患者及其他患病治疗中较长期卧床的患者等，都有大量出现并发褥疮情况，因此,褥疮的预防治疗以及护理成为一项艰巨而重要的工作,也是护理工作中长期存在而未完全解决的一大难题。
目前，临床上治疗褥疮常用的方法包括手术治疗方法，药物治疗方法和外敷方法。手术治疗主要是采用彻底清创后皮瓣转移修复，但该方法对于许多病人并不适合；药物疗法，包括内服药和外用药，也普遍存在效果不够明显的缺点。由于外敷方法简单易操作，且对病人的伤害最小，因此，许多临床研究也给以极大关注。传统创伤敷料包括棉纱绷带、绷带/卷装绷带、专用敷料、浸渍棉纱、豁合条带制品以及应急处理敷料杂品等，主要体现止血、防菌、防止伤口粘连和简单的包扎功能。显然，传统创伤敷料在褥疮治疗中无法满足要求。
生物敷料是在Winter等提出的创伤修复“湿润愈合”理论基础上发展起来的新型创面修复及保护材料。与传统敷料相比，生物敷料具有降低感染、提高创面愈合质量、减轻病人的痛苦以及方便医护人员操作等优点，因此得到了人们的青睐。目前，我国市场具有自主知识产权的并用于褥疮修复的敷料还很少，几乎是空白。因此，研究新型的用于治疗褥疮的敷料与制备方法，具有极其重要的意义。
发明内容
本发明的目的在于针对现有技术的不足，提供一种治疗褥疮生物敷料的制备方法。
本发明的目的是通过以下技术方案实现的：一种治疗褥疮生物敷料的制备方法，该制备方法包括以下步骤：按重量份计，称取透明质酸30-40份、天然胶乳30-34份、海藻酸盐5-12份、大黄粉14-20份、香薷粉6-10份、苦地丁粉10-18份、白芷粉10-20份、墨旱莲粉8-12份、蒲公英粉8-12份、甘草酸二钾6-10份、透明质酸钠10-14份、乳化剂11-17份和水30-40份置于反应器中，超声高速分散，超声波频率为30-40KHz，分散速度5000-5400r/min，分散时间为30-40min；然后将分散后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
所述基布层为无纺布或PU防水透气膜。
所述粘结剂为压敏胶。
所述海藻酸盐为海藻酸钾、海藻酸钠或海藻酸钙。
所述乳化剂为硬脂酸单甘油脂或十二烷基硫酸钠。
本发明具有以下有益效果：通过本发明的方法制备的生物敷料采用中药配方，刺激性小，无毒副作用，不易复发，具有生物相容性好。抗菌消炎止血效果好，水率高、扯断和撕裂强度好、阻止渗液溢出，促进肉芽组织和上皮组织的形成，皮肤组织愈合和修复快，对褥疮引起的出血、肿胀、疼痛等均有很好的疗效。
具体实施方式
实施例1
一种治疗褥疮生物敷料的制备方法，该制备方法包括以下步骤：按重量份计，称取透明质酸30份、天然胶乳30份、海藻酸盐5份、大黄粉14份、香薷粉6份、苦地丁粉10份、白芷粉10份、墨旱莲粉8份、蒲公英粉8份、甘草酸二钾6份、透明质酸钠10份、乳化剂11份和水30份置于反应器中，超声高速分散，超声波频率为30-40KHz，分散速度5000-5400r/min，分散时间为30-40min；然后将分散后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
所述基布层为无纺布或PU防水透气膜。
所述粘结剂为压敏胶。
所述海藻酸盐为海藻酸钾、海藻酸钠或海藻酸钙。
所述乳化剂为硬脂酸单甘油脂或十二烷基硫酸钠。
实施例2
一种治疗褥疮生物敷料的制备方法，该制备方法包括以下步骤：按重量份计，称取透明质酸40份、天然胶乳34份、海藻酸盐12份、大黄粉20份、香薷粉10份、苦地丁粉18份、白芷粉20份、墨旱莲粉12份、蒲公英粉12份、甘草酸二钾10份、透明质酸钠14份、乳化剂17份和水40份置于反应器中，超声高速分散，超声波频率为30-40KHz，分散速度5000-5400r/min，分散时间为30-40min；然后将分散后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
所述基布层为无纺布或PU防水透气膜。
所述粘结剂为压敏胶。
所述海藻酸盐为海藻酸钾、海藻酸钠或海藻酸钙。
所述乳化剂为硬脂酸单甘油脂或十二烷基硫酸钠。
实施例3
一种治疗褥疮生物敷料的制备方法，该制备方法包括以下步骤：按重量份计，称取透明质酸35份、天然胶乳32份、海藻酸盐8份、大黄粉16份、香薷粉8份、苦地丁粉14份、白芷粉15份、墨旱莲粉10份、蒲公英粉10份、甘草酸二钾8份、透明质酸钠12份、乳化剂14份和水35份置于反应器中，超声高速分散，超声波频率为30-40KHz，分散速度5000-5400r/min，分散时间为30-40min；然后将分散后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
所述基布层为无纺布或PU防水透气膜。
所述粘结剂为压敏胶。
所述海藻酸盐为海藻酸钾、海藻酸钠或海藻酸钙。
所述乳化剂为硬脂酸单甘油脂或十二烷基硫酸钠。

Claims (5)

1.一种治疗褥疮生物敷料的制备方法，其特征在于该制备方法包括以下步骤：按重量份计，称取透明质酸30-40份、天然胶乳30-34份、海藻酸盐5-12份、大黄粉14-20份、香薷粉6-10份、苦地丁粉10-18份、白芷粉10-20份、墨旱莲粉8-12份、蒲公英粉8-12份、甘草酸二钾6-10份、透明质酸钠10-14份、乳化剂11-17份和水30-40份置于反应器中，超声高速分散，超声波频率为30-40KHz，分散速度5000-5400r/min，分散时间为30-40min；然后将分散后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
2.根据权利要求1所述一种治疗褥疮生物敷料的制备方法，其特征在于：所述基布层为无纺布或PU防水透气膜。
3.根据权利要求1所述一种治疗褥疮生物敷料的制备方法，其特征在于：所述粘结剂为压敏胶。
4.根据权利要求1所述一种治疗褥疮生物敷料的制备方法，其特征在于：所述海藻酸盐为海藻酸钾、海藻酸钠或海藻酸钙。
5.根据权利要求1所述一种治疗褥疮生物敷料的制备方法，其特征在于：所述乳化剂为硬脂酸单甘油脂或十二烷基硫酸钠。
CN201610140668.5A 2016-03-14 2016-03-14 一种治疗褥疮生物敷料的制备方法 Pending CN105688259A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610140668.5A CN105688259A (zh) 2016-03-14 2016-03-14 一种治疗褥疮生物敷料的制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610140668.5A CN105688259A (zh) 2016-03-14 2016-03-14 一种治疗褥疮生物敷料的制备方法

Publications (1)

Publication Number Publication Date
CN105688259A true CN105688259A (zh) 2016-06-22

Family

ID=56221429

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610140668.5A Pending CN105688259A (zh) 2016-03-14 2016-03-14 一种治疗褥疮生物敷料的制备方法

Country Status (1)

Country Link
CN (1) CN105688259A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110353883A (zh) * 2019-07-10 2019-10-22 重庆市人民医院 用于治疗褥疮的复合敷料层及带有复合敷料层的褥疮贴

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101461960A (zh) * 2007-12-18 2009-06-24 王淑琳 褥疮生物敷料
US20120064145A1 (en) * 2010-09-09 2012-03-15 China Medical University Wound dressing
CN104208743A (zh) * 2014-08-18 2014-12-17 朱世真 一种止血镇痛敷料
CN104324411A (zh) * 2014-09-28 2015-02-04 张亚峰 一种医用天然海洋生物敷料
CN104874008A (zh) * 2015-05-22 2015-09-02 苏州市贝克生物科技有限公司 一种医用生物抗菌敷料的制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101461960A (zh) * 2007-12-18 2009-06-24 王淑琳 褥疮生物敷料
US20120064145A1 (en) * 2010-09-09 2012-03-15 China Medical University Wound dressing
CN104208743A (zh) * 2014-08-18 2014-12-17 朱世真 一种止血镇痛敷料
CN104324411A (zh) * 2014-09-28 2015-02-04 张亚峰 一种医用天然海洋生物敷料
CN104874008A (zh) * 2015-05-22 2015-09-02 苏州市贝克生物科技有限公司 一种医用生物抗菌敷料的制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110353883A (zh) * 2019-07-10 2019-10-22 重庆市人民医院 用于治疗褥疮的复合敷料层及带有复合敷料层的褥疮贴

Similar Documents

Publication Publication Date Title
CN106581736B (zh) 原料为娃娃鱼体表黏液的医用粘合剂及制备方法
CN201333128Y (zh) 一种保健型创口贴
CN103933603B (zh) 一种壳聚糖促人表皮生长生物医用胶及其制备方法
CN103316261A (zh) 一种医用抗菌液及其制备方法
CN107320768A (zh) 用于创伤修复含有干细胞提取物的敷料及其制备方法
CN1481833A (zh) 一种治疗烧烫伤的外用药
CN103055107A (zh) 一种芦荟伤口贴及其制备方法
CN101757347B (zh) 断血创可贴及其制备方法
CN105726400A (zh) 一种美白护肤生物敷料的制备方法
TW200942270A (en) Chinese medicine composition for treatment of wounds or bedsore, and method for producing preparation thereof
CN105688259A (zh) 一种治疗褥疮生物敷料的制备方法
CN100363016C (zh) 一种外伤快速愈合复方中药散剂及其制备方法
CN205252142U (zh) 一种外科手术消毒复合纱布
CN105770973A (zh) 一种医用褥疮生物敷料的制备方法
CN103690903B (zh) 一种治疗烧烫伤褥疮等外伤疾病的复方中药制剂
CN105688262A (zh) 一种祛疤生物敷料的制备方法
CN202458908U (zh) 新型创可贴
CN105770974A (zh) 一种医用痔疮生物敷料的制备方法
CN105726399A (zh) 一种用于疤痕修复生物敷料的制备方法
CN104983936A (zh) 一种临床护理上用于治疗三期褥疮的中药膏剂
CN105709261A (zh) 一种治疗痔疮生物敷料的制备方法
CN104436276A (zh) 一种用于女士卫生纸内裤上的弱酸粉体
CN115645476A (zh) 一种刀枪外伤拔毒生肌散的使用方法、刀枪外伤拔毒生肌散和制备方法
CN105687087A (zh) 一种紧肤袪斑生物敷料的制备方法
CN203042644U (zh) 一种芦荟伤口贴

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20160622