CN105770740A - Spray for fast relieving postoperation pain - Google Patents
Spray for fast relieving postoperation pain Download PDFInfo
- Publication number
- CN105770740A CN105770740A CN201610217801.2A CN201610217801A CN105770740A CN 105770740 A CN105770740 A CN 105770740A CN 201610217801 A CN201610217801 A CN 201610217801A CN 105770740 A CN105770740 A CN 105770740A
- Authority
- CN
- China
- Prior art keywords
- parts
- spray
- preparation
- pain
- gained
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to spray for fast relieving postoperation pain. The spray is prepared from, by weight, 5-10 parts of zanthoxylum bungeanum seeds, 8-12 parts of pseudo-ginseng, 10-15 parts of diverse wormwood herb, 12-18 parts of cuttlebone, 15-20 parts of fructus viticis, 6-9 parts of radix curcumae longae, 1-5 parts of radix aconite, 8-12 parts of radix clematidis, 10-20 parts of honeysuckle flower, 8-16 parts of frankincense and 9-17 parts of rhizoma dioscoreae nipponicae. The spray is scientific in formula, mild in drug property, free of toxic and side effects, and capable of taking effect fast being in a spray dosage form.
Description
Divisional application, original applying number 2014102881174, applying date 2014.06.25, title one quickly alleviates postoperative
The spray of pain and preparation method.
Technical field
The present invention relates to a kind of spray quickly alleviating postoperative pain and preparation method, belong to traditional Chinese medicine field,
It is mainly used in quickly alleviating postoperative pain.
Background technology
All mentioning to perform an operation, and few people do not fear, one of reason is the insufferable pain of Post operation.Investigation is sent out
Existing, pain can be feared and cause worry, anxiety and uneasiness by the surgical patient of about 95%, and some then causes nervous, blood pressure increasing
High.Postoperative dare not firmly breathe, cough and rotate position because of pain, secretions is difficult to discharge, and causes pulmonary atelectasis and pulmonary's sense
Dye etc..For a long time, it is believed that postoperative pain is inevitable, traditional analgesia method the most simply injects morphine, pethidine
Deng analgesic drug product, but it is short to there is analgesia time, needs the shortcomings such as medication repeatedly.
In the invention of the existing Chinese medicine preparation alleviating postoperative pain, application publication number CN 103735867 A(application number
201410044132.4) Chinese patent literature disclose a kind of granule for children with postoperative pain and preparation method thereof.
Its preparation method includes: (1) by Folium fici wightianae (Ficus wightiana Wall), Semen Armeniacae Amarum, Ramulus Cinnamomi, Herba Sarcandrae, Folium eucalypti globueli (Eucalyptus globulus Labill.), Myriogyne minuta coarse powder respectively with vapor distillation
Method extracts mixing for standby use after volatile oil, and collection, and medicinal residues are continued to employ;(2) Nostoc, Herba Calystegiae Japonicae, Herba Dendrobii, Fructus Trichosanthis, Semen Celosiae, wood
In melon, and step 1, gained medicinal residues mix and add 10 times of water yields, boiling 2 times, each 1 hour, and collecting decoction stands;So
Afterwards toward the ethanol of the 95% of 3 ~ 4 times of medicinal liquids of addition in decocting liquid, stand 15 minutes, be then centrifuged 20 points with 3000rpm/min
Clock, takes clear liquid, is spray-dried after concentration, draws just material;(3) by material at the beginning of gained volatile oil sprays into step 3 gained in step 1,
Pulverizing 60 mesh sieves, subpackage forms.Authorization Notice No. CN 102579579 B(application number 201210076086.7) China
Patent documentation discloses the pharmaceutical composition of a kind of perianal anaesthetic analgesia of postoperation, and preferred scheme is that said composition includes following
The raw material of weight proportion: procaine 2 ~ 8 parts;Eugenol 2 ~ 8 parts;Natural gum 10 ~ 20 parts;Borneolum Syntheticum 1 ~ 5 part;Litsea cubeba oil
10 ~ 20 parts;Thalcimine 1 ~ 3 part.
At present, the prior art including above-mentioned patent documentation remains deficiency in terms of solving to alleviate postoperative pain, than
As uncertain therapeutic efficacy is cut, with high costs etc..A kind of spray quickly alleviating postoperative pain is badly in need of in clinical practice.
Summary of the invention
For the present situation of postoperative pain, it is an object of the invention to provide a kind of spray quickly alleviating postoperative pain and
Preparation method.
The above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of spray quickly alleviating postoperative pain, takes off and states the primary raw material of weight proportion and be prepared from: Pericarpium Zanthoxyli 5-10 part,
Radix Notoginseng 8-12 part, Herba Artemisiae Anomalae 10-15 part, Endoconcha Sepiae 12-18 part, Fructus Viticis 15-20 part, Rhizoma Curcumae Longae 6-9 part, Radix Aconiti Kusnezoffii 1-5 part, prestige
Radix Clematidis 8-12 part, Flos Lonicerae 10-20 part, Olibanum 8-16 part, Rhizoma Dioscoreae Nipponicae 9-17 part.
Above-mentioned a kind of spray quickly alleviating postoperative pain, preferred scheme, take off the primary raw material stating weight proportion
It is prepared from: Pericarpium Zanthoxyli 6-9 part, Radix Notoginseng 9-11 part, Herba Artemisiae Anomalae 11-14 part, Endoconcha Sepiae 13-17 part, Fructus Viticis 16-19 part, Rhizoma Curcumae Longae
7-8 part, Radix Aconiti Kusnezoffii 2-4 part, Radix Clematidis 9-11 part, Flos Lonicerae 13-17 part, Olibanum 10-14 part, Rhizoma Dioscoreae Nipponicae 12-14 part.
One of the above quickly alleviates the spray of postoperative pain, and more preferably preferably scheme, takes off and state the main of weight proportion
Raw material is prepared from: 8 parts of Pericarpium Zanthoxyli, Radix Notoginseng 10 parts, Herba Artemisiae Anomalae 13 parts, Endoconcha Sepiae 15 parts, Fructus Viticis 18 parts, 8 parts of Rhizoma Curcumae Longae, Radix Aconiti Kusnezoffii
3 parts, Radix Clematidis 10 parts, Flos Lonicerae 15 parts, Olibanum 12 parts, Rhizoma Dioscoreae Nipponicae 13 parts.
According to any of the above described spray, its preparation methods steps is as follows:
(1) being pulverized by Pericarpium Zanthoxyli, cross 80-100 mesh sieve, load in extraction kettle, the temperature of extraction kettle is 35-45 DEG C (preferably 40 DEG C),
Pressure is the preferred 22.5MPa of 15-30MPa(), being passed through flow in extraction kettle is the preferred 27.5L/h of 15-40L/h() CO2And
Extracting 3-5 hour, after extraction, gained Fructus Zanthoxyli oil is collected in decompression;
(2) Endoconcha Sepiae, Radix Aconiti Kusnezoffii and Fructus Viticis are pulverized, with the soaking in Chinese liquor 5-10 day of 40-50 DEG C, take out, dry, stand-by;
(3) Olibanum taking cleaning is placed in marmite, heats with slow fire, fries to smoldering, and surface is micro-molten, sprays rice vinegar in pot, then
Frying and show glossy gloss to surface, taking-up cools, standby;
(4) by Radix Notoginseng, Rhizoma Curcumae Longae, Radix Clematidis and Flos Lonicerae warm water soaking 30 minutes, 5-10 times amount soak by water is added 1-2 hour, mistake
Filter, adds the Olibanum after Herba Artemisiae Anomalae, Rhizoma Dioscoreae Nipponicae and step (3) after cleaning process in gained filtrate, and intense fire is decocted to boiling, then
With slow fire boiling 1-3 hour (preferably 2 hours), after decoction, carry out centrifugation, take supernatant, add step (2) gained medicated powder,
Stand-by;
(5) step (1) gained Fructus Zanthoxyli oil is added in step (4) gained mixture, agitated rear mix homogeneously, it is aided with pharmaceutically
Acceptable carrier packs to obtain spray.
According to preparation method recited above, preferred scheme is, step (1) crosses 85-95 mesh sieve (preferably 90 mesh sieve).
According to preparation method recited above, preferred scheme is, step (1) extraction time is 4 hours.
According to preparation method recited above, preferred scheme is, the temperature of step (2) described Chinese liquor be 43-47 DEG C (excellent
Select 45 DEG C).
According to preparation method recited above, preferred scheme is, step (2) soak time is 6-9 day (preferably 7 days).
According to preparation method recited above, preferred scheme is, step (4) described amount of water is 7-8 times and (preferably adds water
Amount is 8 times).
According to preparation method recited above, preferred scheme is, step (4) decocting time for the first time is 1.5 hours.
Using method: for making the present invention reach optimal using effect, during use, sprays Chinese medicine of the present invention when pain occurs
Mist agent is sprayed at rapidly affected part, the most in right amount, sprays 3-8 minute, and situation severe patient sprays 15-30 minute, and one for several times, 5 days
It it is a course for the treatment of.
A kind of spray quickly alleviating postoperative pain, the pharmacological effect of each raw material is respectively as follows:
Pericarpium Zanthoxyli: pungent, temperature, mild toxicity.Return spleen, stomach, kidney channel.Effect: warming middle-JIAO to relieve pain, dehumidify antidiarrheal, killing parasites for relieving itching.Cure mainly Deficiency and coldness of spleen and stomach
Type coldness and pain in the epigastrium, ascarid suffers from abdominal pain, and vomiting has loose bowels, lung cold cough with asthma, toothache due to dental caries, pudendal pruritus leukorrhagia, eczema skin pruritus.
Radix Notoginseng: hardship sweet, micro-, temperature.Return liver, lung, the heart, large intestine channel.Effect: hemostasis dissipating blood stasis, subduing swelling and relieving pain.Cure mainly haematemesis, cough
Blood, hematuria, have blood in stool, dysentery, metrorrhagia, postpartum hemorrhage, traumatic hemorrhage, injury from falling down, obstruction of qi in the chest and cardialgia, the most bitterly, abdominal mass amasss block to the gastral cavity side of body,
Blood stasis amenorrhea, dysmenorrhea, puerperal the stagnant stomachache of the stasis of blood, sore, carbuncle and painful swelling.
Herba Artemisiae Anomalae: for the wounded in the battle herb of Compositae sagebruss artemisia anomalas.The property of medicine: bitter, pungent, temperature.GUIXIN, liver, spleen channel.Effect: removing blood stasis
Dysmenorrhea, removing food stagnancy, hemostasia and detumescence.Cure mainly amenorrhea due to stagnation of blood, dysmenorrhea, puerperal the stagnant stomachache of the stasis of blood, abdominal mass, abdominal pain due to retention of food, traumatic injury, incised wound
Hemorrhage, hematuria, carbuncle poison, scald.
Endoconcha Sepiae: for the inner shell of the multiple sepiellae seu sepiaes such as Sepiidae sepiella maindroni de Rochebrune, Sepia animal golden cuttlefish.The property of medicine: salty, puckery,
Temperature.Return liver, kidney channel.Effect: astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.Cure mainly haematemesis, hematemesis, metrorrhagia, just
Blood, epistaxis, wound hemorrhage, emission due to deficiency of the kidney spermatorrhea, leucorrhea with red and white discharge, have a stomachache noisy, belch pantothenic acid, eczema ulcer.
Fructus Viticis: for Verenaceae Du's chaste tree platymiscium Vitex rotundifolia and the fruit of wild pepper.The property of medicine: pungent, bitter, is slightly cold.Return lung,
Liver, stomach warp.Effect: dispelling wind and heat pathogens, the clear profit head.Cure mainly affection due to external wind and heat, dizzy headache, migraine, gingival swelling and pain, conjunctival congestion and swelling pain
Many tears, pain in mesh eyeball, dim not clear, arthralgia chiefly caused by damp pathogen contracture.
Rhizoma Curcumae Longae: bitter, pungent, temperature.Return spleen, Liver Channel.Effect: removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.Cure mainly all cards of stagnation of QI and blood, chest and abdomen
Hypochondriac pain, dysmenorrhes, amenorrhea, puerperal the stagnant stomachache of the stasis of blood, rheumatic arthralgia, traumatic injury, carbuncle, all skin ulcer tinea nascent sufferings.
Radix Aconiti Kusnezoffii: for the tuber of Ranunculaceae aconitum plant Aconitum carmichjaelii Debx. (wild species), Aconitum kusnezoffii Reichb etc..The property of medicine: pungent, bitter, heat, greatly
Poison.GUIXIN, liver, spleen channel.Effect: expelling wind and removing dampness, dispelling cold by warming the meridian, reducing swelling and alleviating pain.Cure mainly anemofrigid-damp arthralgia, arthralgia, wind syndrome of head head
Bitterly, apoplectic dyscinesia, trusted subordinate's cold type of pain, colic of cold type has a pain, traumatic injury, swelling and pain due to blood stasis, resistance carbuncle poison etc..And can be used for narcotic analgesic.
Radix Clematidis: for Ranunculaceae Actions of Clematis Species Radix Clematidis, Clematis hexapetala, the root and rhizome of northeast clematis.Medicine
Property: hardship pungent, salty, micro-, temperature, mild toxicity.Return bladder, Liver Channel.Effect: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.Cure mainly rheumatic arthralgia, limbs fiber crops
Wood, muscle arteries and veins contracture, joint stuffiness, tinea pedis swells and ache, malaria, and bone is choked with sobs larynx.And control phlegm retention accumulation.
Flos Lonicerae: sweet, cold.Attach to the lung and stomach meridians.Effect: heat-clearing and toxic substances removing.Cure mainly affection due to external wind and heat or epidemic febrile disease heating, heatstroke, pyretic toxicity
Dysentery, carbuncle furuncle, sore throat, multi-infection disease.
Olibanum: the factice tree oozed out for skin zones such as Burseraceae Boswellia Boswellia carterii, Bao Da Boswellia carterii, wild Boswellia carteriis
Fat.The property of medicine: pungent, bitter, temperature.GUIXIN, liver, spleen channel.Effect: invigorate blood circulation, circulation of qi promoting, pain relieving.Cure mainly trusted subordinate's pain, amenorrhea, dysmenorrhea, puerperal
The stagnant stomachache of the stasis of blood, traumatic injury stasis of blood pain, swollen ulcer drug, the sore being festered and unhealed.
Rhizoma Dioscoreae Nipponicae: for Dioscoreaceae yam Dioscorea nipponica Mak. Ningpo Yam Rhizome and the rhizome of bavin Dioscorea zingiberensis.The property of medicine: bitter, flat.Return liver, lung meridian.
Effect: expelling wind and removing dampness, invigorates blood circulation, cough-relieving.Cure mainly rheumatic arthralgia, numb limbs and tense tendons, rheumatic fever, obstruction of qi in the chest and cardialgia, stomachache, Chronic Airway
Inflammation, traumatic injury, strain, malaria, carbuncle, chilblain.
It is an advantage of the current invention that:
A kind of quickly spray alleviating postoperative pain that the present invention provides and preparation method thereof, the Herba Artemisiae Anomalae in prescription, sea Piao
Octopus ocellatus Gray, Radix Aconiti Kusnezoffii, Radix Clematidis, Olibanum and Rhizoma Dioscoreae Nipponicae all have effect of astringing to arrest bleeding and reducing swelling and alleviating pain, by playing synergism
Effectively alleviate postoperative pain symptom;Flos Lonicerae has heat-clearing toxin-expelling functions, both can eliminate the poison of other drug in this prescription
Property, avoid again the property of medicine excessively to warm, damage health;And Pericarpium Zanthoxyli, Radix Notoginseng, Fructus Viticis and the Rhizoma Curcumae Longae in this prescription had both strengthened this medicine
The analgesic activity of side, again in the property of medicine and the efficacy of a drug of returning classical prescription this medicine of face balance;Chinese medicine contained by the present invention is made and pharmaceutically can connect
The spray being subject to, is sprayed at affected part when panic attacks, pain can be made to alleviate at once with fast onset.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited by this.
Embodiment 1 one kinds quickly alleviates the spray of postoperative pain, takes off and states the primary raw material of weight proportion and be prepared from
5 parts of (every part takes 8g) Pericarpium Zanthoxyli, Radix Notoginseng 8 parts, Herba Artemisiae Anomalae 10 parts, Endoconcha Sepiae 12 parts, Fructus Viticis 15 parts, 6 parts of Rhizoma Curcumae Longae, Radix Aconiti Kusnezoffii 1 part,
Radix Clematidis 8 parts, Flos Lonicerae 10 parts, Olibanum 8 parts, Rhizoma Dioscoreae Nipponicae 9 parts.
The preparation method of above-mentioned a kind of spray quickly alleviating postoperative pain, step is as follows:
(1) being pulverized by Pericarpium Zanthoxyli, cross 80 mesh sieves, load in extraction kettle, the temperature of extraction kettle is 35 DEG C, and pressure is 15MPa, to extraction
Still is passed through the CO that flow is 15L/h2And extract 3 hours, after extraction, gained Fructus Zanthoxyli oil is collected in decompression;
(2) Endoconcha Sepiae, Radix Aconiti Kusnezoffii and Fructus Viticis are pulverized, with the soaking in Chinese liquor 5 days of 40 DEG C, taking-up, dry, stand-by;
(3) Olibanum taking cleaning is placed in marmite, heats with slow fire, fries to smoldering, and surface is micro-molten, sprays rice vinegar in pot, then
Frying and show glossy gloss to surface, taking-up cools, standby;
(4) by Radix Notoginseng, Rhizoma Curcumae Longae, Radix Clematidis and Flos Lonicerae warm water soaking 30 minutes, add 5 times amount soak by water 1 hour, filter, to
Adding the Olibanum after Herba Artemisiae Anomalae, Rhizoma Dioscoreae Nipponicae and step (3) after cleaning process in gained filtrate, intense fire boils to boiling, then with civilian
Fire decocts 1 hour, carries out centrifugation after decoction, takes supernatant, adds step (2) gained medicated powder, stand-by;
(5) step (1) gained Fructus Zanthoxyli oil is added in step (4) gained mixture, agitated rear mix homogeneously, it is aided with pharmaceutically
Acceptable carrier packs to obtain spray of the present invention.
Typical case one Lee XX, man, 56 years old.Because of traffic accident before first quarter moon, left side fracture of scapula, after underwent operative, affected part is often felt
Feeling to insufferable pain, particularly under kinestate, movable upper limb all can produce pain, the most just when even walking
It is often that behavioral activity is restricted, has a strong impact on the orthobiosis of patient.
Embodiment 1 gained medicinal herb spray, when pain occurs, is sprayed at rapidly at omoplate, every time spraying 3-8 minute.Use
After 10 days, panic attacks reduces, and after coating, pain alleviates rapidly;After using 15 days, during non-injured limb activity, affected part is no longer sent out
Very painful pain, livelihood restoration is normal.
Embodiment 2 one kinds quickly alleviates the spray of postoperative pain, takes off and states the primary raw material of weight proportion and be prepared from
(every part takes 4g): 10 parts of Pericarpium Zanthoxyli, Radix Notoginseng 12 parts, Herba Artemisiae Anomalae 15 parts, Endoconcha Sepiae 18 parts, Fructus Viticis 20 parts, 9 parts of Rhizoma Curcumae Longae, Radix Aconiti Kusnezoffii 5
Part, Radix Clematidis 12 parts, Flos Lonicerae 20 parts, Olibanum 16 parts, Rhizoma Dioscoreae Nipponicae 17 parts.
The preparation method of above-mentioned a kind of spray quickly alleviating postoperative pain, step is as follows:
(1) being pulverized by Pericarpium Zanthoxyli, cross 100 mesh sieves, load in extraction kettle, the temperature of extraction kettle is 45 DEG C, and pressure is 30MPa, Xiang Cui
Take and still is passed through the CO that flow is 40L/h2And extract 5 hours, after extraction, gained Fructus Zanthoxyli oil is collected in decompression;
(2) Endoconcha Sepiae, Radix Aconiti Kusnezoffii and Fructus Viticis are pulverized, with the soaking in Chinese liquor 10 days of 50 DEG C, taking-up, dry, stand-by;
(3) Olibanum taking cleaning is placed in marmite, heats with slow fire, fries to smoldering, and surface is micro-molten, sprays rice vinegar in pot, then
Frying and show glossy gloss to surface, taking-up cools, standby;
(4) by Radix Notoginseng, Rhizoma Curcumae Longae, Radix Clematidis and Flos Lonicerae warm water soaking 30 minutes, add 10 times amount soak by water 2 hours, filter, to
Adding the Olibanum after Herba Artemisiae Anomalae, Rhizoma Dioscoreae Nipponicae and step (3) after cleaning process in gained filtrate, intense fire is decocted to boiling, then with civilian
Fire decocts 3 hours, carries out centrifugation after decoction, takes supernatant, adds step (2) gained medicated powder, stand-by;
(5) step (1) gained Fructus Zanthoxyli oil is added in step (4) gained mixture, agitated rear mix homogeneously, it is aided with pharmaceutically
Acceptable carrier packs to obtain spray of the present invention.
Embodiment 3 one kinds quickly alleviates the spray of postoperative pain, takes off and states the primary raw material of weight proportion and be prepared from
(every part takes 20g): 6 parts of Pericarpium Zanthoxyli, Radix Notoginseng 9 parts, Herba Artemisiae Anomalae 11 parts, Endoconcha Sepiae 13 parts, Fructus Viticis 16 parts, 7 parts of Rhizoma Curcumae Longae, Radix Aconiti Kusnezoffii 2
Part, Radix Clematidis 9 parts, Flos Lonicerae 13 parts, Olibanum 10 parts, Rhizoma Dioscoreae Nipponicae 12 parts.
The preparation method of above-mentioned a kind of spray quickly alleviating postoperative pain, step is as follows:
(1) being pulverized by Pericarpium Zanthoxyli, cross 85 mesh sieves, load in extraction kettle, the temperature of extraction kettle is 35 DEG C, and pressure is 15MPa, to extraction
Still is passed through the CO that flow is 15L/h2And extract 3-5 hour, after extraction, gained Fructus Zanthoxyli oil is collected in decompression;
(2) Endoconcha Sepiae, Radix Aconiti Kusnezoffii and Fructus Viticis are pulverized, with the soaking in Chinese liquor 6 days of 43 DEG C, taking-up, dry, stand-by;
(3) Olibanum taking cleaning is placed in marmite, heats with slow fire, fries to smoldering, and surface is micro-molten, sprays rice vinegar in pot, then
Frying and show glossy gloss to surface, taking-up cools, standby;
(4) by Radix Notoginseng, Rhizoma Curcumae Longae, Radix Clematidis and Flos Lonicerae warm water soaking 30 minutes, add 7 times amount soak by water 1-2 hour, filter,
Adding the Olibanum after Herba Artemisiae Anomalae, Rhizoma Dioscoreae Nipponicae and step (3) after cleaning process in gained filtrate, intense fire is decocted to boiling, then is used
Slow fire boiling 1 hour, carries out centrifugation after decoction, take supernatant, adds step (2) gained medicated powder, stand-by;
(5) step (1) gained Fructus Zanthoxyli oil is added in step (4) gained mixture, agitated rear mix homogeneously, it is aided with pharmaceutically
Acceptable carrier packs to obtain spray of the present invention.
Embodiment 4 one kinds quickly alleviates the spray of postoperative pain, takes off and states the primary raw material of weight proportion and be prepared from
(every part takes 15g): Pericarpium Zanthoxyli 6-9 part, Radix Notoginseng 9-11 part, Herba Artemisiae Anomalae 11-14 part, Endoconcha Sepiae 13-17 part, Fructus Viticis 16-19 part, Rhizoma Zingiberis Recens
Yellow 7-8 part, Radix Aconiti Kusnezoffii 2-4 part, Radix Clematidis 9-11 part, Flos Lonicerae 13-17 part, Olibanum 10-14 part, Rhizoma Dioscoreae Nipponicae 12-14 part.
The preparation method of above-mentioned a kind of spray alleviating postoperative pain, step is as follows:
(1) being pulverized by Pericarpium Zanthoxyli, cross 95 mesh sieves, load in extraction kettle, the temperature of extraction kettle is 45 DEG C, and pressure is 30MPa, to extraction
Still is passed through the CO that flow is 40L/h2And extract 5 hours, after extraction, gained Fructus Zanthoxyli oil is collected in decompression;
(2) Endoconcha Sepiae, Radix Aconiti Kusnezoffii and Fructus Viticis are pulverized, with the soaking in Chinese liquor 9 days of 47 DEG C, taking-up, dry, stand-by;
(3) Olibanum taking cleaning is placed in marmite, heats with slow fire, fries to smoldering, and surface is micro-molten, sprays rice vinegar in pot, then
Frying and show glossy gloss to surface, taking-up cools, standby;
(4) by Radix Notoginseng, Rhizoma Curcumae Longae, Radix Clematidis and Flos Lonicerae warm water soaking 30 minutes, add 5-10 times amount soak by water 2 hours, filter,
Adding the Olibanum after Herba Artemisiae Anomalae, Rhizoma Dioscoreae Nipponicae and step (3) after cleaning process in gained filtrate, intense fire is decocted to boiling, then is used
Slow fire boiling 3 hours, carries out centrifugation after decoction, take supernatant, adds step (2) gained medicated powder, stand-by;
(5) step (1) gained Fructus Zanthoxyli oil is added in step (4) gained mixture, agitated rear mix homogeneously, it is aided with pharmaceutically
Acceptable carrier packs to obtain spray of the present invention.
Typical case two grandson XX, man, 37 years old.March, cause unexpected was injured by a crashing object left side chest and back by stone, felt pain, uncomfortable in chest and
The symptoms such as dyspnea, accompanies cough, expectoration and sputum mixed with blood, has slight nervous, tachypnea, Nausea and vomiting, and with intermittent confused
Fan, Survive the perils of life after emergency operation.The pain of postoperative patients causes muscular tension to increase, and ventilatory function reduces, and lung is suitable
Answering property declines.Patient limits cough function because of wound pain, affects the discharge of respiratory secretions, occurs after promoting operation in patients
Pulmonary infection and pulmonary atelectasis.
Gained medicinal herb spray in embodiment 4, every day is early, middle and late is respectively sprayed at surgical wound 1 time, each 30 minutes,
Spray 8 minutes in sore place during acute pain episodes, reach the effect alleviated rapidly.Using 35 days, respiratory system recovers substantially
Normally;Using 60 days, complication and pain are wholly absent, and surgical wound recovers normal.
Embodiment 5 one kinds alleviates the spray of postoperative pain, takes off and states the primary raw material of weight proportion and be prepared from (every
Part takes 18g): 8 parts of Pericarpium Zanthoxyli, Radix Notoginseng 10 parts, Herba Artemisiae Anomalae 13 parts, Endoconcha Sepiae 15 parts, Fructus Viticis 18 parts, 8 parts of Rhizoma Curcumae Longae, Radix Aconiti Kusnezoffii 3 parts,
Radix Clematidis 10 parts, Flos Lonicerae 15 parts, Olibanum 12 parts, Rhizoma Dioscoreae Nipponicae 13 parts.
The preparation method of above-mentioned a kind of spray alleviating postoperative pain, step is as follows:
(1) being pulverized by Pericarpium Zanthoxyli, cross 90 mesh sieves, load in extraction kettle, the temperature of extraction kettle is 40 DEG C, and pressure is 23MPa, to extraction
Still is passed through the CO that flow is 27.5L/h2And extract 4 hours, after extraction, gained Fructus Zanthoxyli oil is collected in decompression;
(2) Endoconcha Sepiae, Radix Aconiti Kusnezoffii and Fructus Viticis are pulverized, with the soaking in Chinese liquor 7 days of 45 DEG C, taking-up, dry, stand-by;
(3) Olibanum taking cleaning is placed in marmite, heats with slow fire, fries to smoldering, and surface is micro-molten, sprays rice vinegar in pot, then
Frying and show glossy gloss to surface, taking-up cools, standby;
(4) by Radix Notoginseng, Rhizoma Curcumae Longae, Radix Clematidis and Flos Lonicerae warm water soaking 30 minutes, add 8 times amount soak by water 1.5 hours, filter,
Adding the Olibanum after Herba Artemisiae Anomalae, Rhizoma Dioscoreae Nipponicae and step (3) after cleaning process in gained filtrate, intense fire is decocted to boiling, then is used
Slow fire boiling 2 hours, carries out centrifugation after decoction, take supernatant, adds step (2) gained medicated powder, stand-by;
(5) step (1) gained Fructus Zanthoxyli oil is added in step (4) gained mixture, agitated rear mix homogeneously, it is aided with pharmaceutically
Acceptable carrier packs to obtain spray of the present invention.
Experimental example
One, experiment basic document:
In order to verify that the Chinese medicine preparation of the present invention has definite curative effect to quickly alleviating postoperative pain, randomly drawed 328 postoperative
Pain patients, the mean age is 43 years old, minimum 18 years old, maximum 65 years old.It is divided into administration group and matched group according to the state of an illness and pathology,
Often organize each 164 people, it is ensured that administration group and matched group situation are basically identical.
Administration group uses the embodiment of the present invention 5 gained medicinal herb spray every day, for making medicinal herb spray of the present invention reach
Good therapeutic effect, by medicinal herb spray direct spraying in affected part, early, middle and late each spraying 1 time every day, one time 8-20 minute, 5 days
It it is a course for the treatment of.Matched group uses other Conventional analgesics (such as acetaminophen and nonsteroidal antiinflammatory drug etc.).
Two, efficacy determination method and standard:
1, decision method: numeric pain intensity scale, uses numerical grade rating scale, and 0 represents the most bitterly, and 10 expressions are the most acutely ached
Bitterly, patient oneself is allowed to iris out a numeral that can represent its pain degree.
2, criterion: the most effective: pain degree is 0-3, and pain alleviates rapidly, and complication is wholly absent;
The most effective: pain degree is 4-7, pain relief, attack times significantly reduces before relatively treating, and complication disappears substantially;
The most invalid: pain degree be 8-10, pain degree and complication all without improve, even increase the weight of.
Observe 50 days time limits, observed once every 10 days, record and add up symptom and the correlation circumstance of all patients.
Three, experimental result and analysis:
Matched group uses other to alleviate the medicine of postoperative pain and administration group uses medicinal herb spray Comparison of therapeutic of the present invention, result
As shown in table 1:
Table 1
Analyze: from table 1 it follows that use medicinal herb spray effective percentage of the present invention to be up to 98.8%, obvious effective rate is up to 97%, and
Not occurring occurring the patient of untoward reaction, effect is substantially good than using other to alleviate the medicine of postoperative pain.
Administration group and matched group all can reach quickly to alleviate the purpose of postoperative pain within the observation period, but in the middle part of matched group
Divide patient after using medicine, to there will be the untoward reaction such as Nausea and vomiting, dizziness, drowsiness, perspiration and xerostomia, and Chinese medicine of the present invention sprays
Mist agent is then because being prepared by natural Chinese medicines, so without any side effects.
Claims (8)
1. the spray quickly alleviating postoperative pain, it is characterised in that take off state weight proportion primary raw material preparation and
Become: 5 parts of Pericarpium Zanthoxyli, Radix Notoginseng 8 parts, Herba Artemisiae Anomalae 10 parts, Endoconcha Sepiae 12 parts, Fructus Viticis 15 parts, 6 parts of Rhizoma Curcumae Longae, Radix Aconiti Kusnezoffii 1 part, Radix Clematidis 8
Part, Flos Lonicerae 10 parts, Olibanum 8 parts, Rhizoma Dioscoreae Nipponicae 9 parts.
The preparation method of spray the most according to claim 1, it is characterised in that step is as follows:
(1) being pulverized by Pericarpium Zanthoxyli, cross 80-100 mesh sieve, load in extraction kettle, the temperature of extraction kettle is 35-45 DEG C (preferably 40 DEG C),
Pressure is the preferred 22.5MPa of 15-30MPa(), being passed through flow in extraction kettle is the preferred 27.5L/h of 15-40L/h() CO2And
Extracting 3-5 hour, after extraction, gained Fructus Zanthoxyli oil is collected in decompression;
(2) Endoconcha Sepiae, Radix Aconiti Kusnezoffii and Fructus Viticis are pulverized, with the soaking in Chinese liquor 5-10 day of 40-50 DEG C, take out, dry, stand-by;
(3) Olibanum taking cleaning is placed in marmite, heats with slow fire, fries to smoldering, and surface is micro-molten, sprays rice vinegar in pot, then
Frying and show glossy gloss to surface, taking-up cools, standby;
(4) by Radix Notoginseng, Rhizoma Curcumae Longae, Radix Clematidis and Flos Lonicerae warm water soaking 30 minutes, 5-10 times amount soak by water is added 1-2 hour, mistake
Filter, adds the Olibanum after Herba Artemisiae Anomalae, Rhizoma Dioscoreae Nipponicae and step (3) after cleaning process in gained filtrate, and intense fire is decocted to boiling, then
With slow fire boiling 1-3 hour (preferably 2 hours), after decoction, carry out centrifugation, take supernatant, add step (2) gained medicated powder,
Stand-by;
(5) step (1) gained Fructus Zanthoxyli oil is added in step (4) gained mixture, agitated rear mix homogeneously, it is aided with pharmaceutically
Acceptable carrier packs to obtain spray of the present invention.
Preparation method the most according to claim 2, it is characterised in that step (1) crosses 85-95 mesh sieve (preferably 90 mesh sieve).
Preparation method the most according to claim 2, it is characterised in that step (1) extraction time is 4 hours.
Preparation method the most according to claim 2, it is characterised in that the temperature of step (2) described Chinese liquor is 43-47 DEG C
(preferably 45 DEG C).
Preparation method the most according to claim 2, it is characterised in that step (2) soak time is 6-9 day (preferably 7 days).
Preparation method the most according to claim 2, it is characterised in that step (4) described amount of water is 7-8 times and (preferably adds
The water yield is 8 times).
Preparation method the most according to claim 2, it is characterised in that step (4) decocting time for the first time is 1.5 hours.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610217801.2A CN105770740A (en) | 2014-06-25 | 2014-06-25 | Spray for fast relieving postoperation pain |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610217801.2A CN105770740A (en) | 2014-06-25 | 2014-06-25 | Spray for fast relieving postoperation pain |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410288117.4A Division CN104027746B (en) | 2014-06-25 | 2014-06-25 | A kind of spray quickly alleviating postoperative pain and preparation method |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105770740A true CN105770740A (en) | 2016-07-20 |
Family
ID=56395091
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610217801.2A Pending CN105770740A (en) | 2014-06-25 | 2014-06-25 | Spray for fast relieving postoperation pain |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105770740A (en) |
-
2014
- 2014-06-25 CN CN201610217801.2A patent/CN105770740A/en active Pending
Non-Patent Citations (3)
Title |
---|
吴章等: "中药热敷加半导体激光治疗腹股沟疝术后疼痛48例", 《四川中医》 * |
张晓: "术后疼痛的研究现状", 《贵阳中医学院学报》 * |
王纪常等: "痛证用药论析", 《安徽中医学院学报》 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104208245B (en) | Tinea manus and pedis Traditional Chinese medicine medicated bath and preparation method | |
CN104825905A (en) | Traditional Chinese medicine preparation for treating blood transfusion reaction and method for manufacturing traditional Chinese medicine preparation | |
CN104027746B (en) | A kind of spray quickly alleviating postoperative pain and preparation method | |
CN104740443A (en) | Traditional Chinese medicine compound essential oil | |
CN104548020A (en) | Application of medicine composition in preparing medicine curing senile dementia | |
CN104189608B (en) | Traditional Chinese medicine preparation for recurrent oral ulcer and preparation method thereof | |
CN103989767B (en) | A kind of treat verruca plana pharmaceutical composition and preparation technology and application | |
CN105770740A (en) | Spray for fast relieving postoperation pain | |
CN105709180A (en) | Spray capable of rapidly relieving postoperative pain and preparation method | |
CN105797069A (en) | Spray for relieving postoperative pain quickly and preparation method of spray | |
CN106729443A (en) | A kind of Chinese medicine composition for swelling and pain relieving and preparation method thereof | |
CN106138740A (en) | A kind of Chinese medicine decoction for treating Qi deficiency blood stasis type cerebral infarction | |
CN104383027A (en) | Chinese medicinal ointment with efficacies of promoting tissue regeneration and setting broken bone and preparation method thereof | |
CN104042851A (en) | Traditional Chinese medicinal liquid for reliving incision pain after anesthesia disappearance and preparation method thereof | |
CN105616559A (en) | Composition for treating acute bacillary dysentery | |
CN104435176B (en) | Soothing the liver medicament and the preparation method of expelling the heat-evil of stamp hypertension on liver-heat | |
CN104383057A (en) | Paste for mainly treating traumatic injury and preparation method of paste for mainly treating traumatic injury | |
CN104474058A (en) | Traditional Chinese medicine liquor for mainly treating traumatic injury and preparation method of traditional Chinese medicine liquor | |
CN104043048A (en) | Medicinal sponge for relieving incision pain after anesthesia disappears and preparation method thereof | |
CN103861062A (en) | Traditional Chinese medicine composition for treating rheumatoid diseases and preparation method thereof | |
CN103784587A (en) | Medicine composition for treating skin diseases of horses | |
CN103656219A (en) | Medicine for treating wound and preparation method of medicine | |
CN106266613A (en) | A kind of Chinese medicine decoction for treating phlegm-heat accumulation type cerebral infarction | |
CN106166263A (en) | The traditional Chinese drug inspissation ball of radical cure malaria | |
CN106237095A (en) | A kind of Chinese medicinal capsule for treating cerebral infarction |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB02 | Change of applicant information |
Address after: 741000 Gansu province Tianshui District Huangcheng Road No. 138 Building 5 room 6-601 Applicant after: Chen Wenling Address before: 250014 Ji'nan Province, Lixia District, Shandong Road, No. 26, No. 1 home, home, building, culture and culture, No. 1201 Applicant before: Chen Wenling |
|
CB02 | Change of applicant information | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160720 |
|
RJ01 | Rejection of invention patent application after publication |