CN105770260A - Traditional Chinese medicine composition for treating allergic rhinitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating allergic rhinitis and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A61K9/00—Medicinal preparations characterised by special physical form
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Abstract
The invention discloses a traditional Chinese medicine composition for treating the allergic rhinitis.The traditional Chinese medicine composition is prepared from Herba Ephedrae, Rhizoma Acori Tatarinowii, radix aconiti preparata, Cortex Mori, rhizoma pinelliae preparata and radix angelicae dahuricae and is further prepared from Michelia alba Dc.and radix astragali.The invention further discloses a preparation method of the traditional Chinese medicine composition.On the aspect of treating the allergic rhinitis, the traditional Chinese medicine composition has the advantages of being good in treatment effect, low in cost, high in cure rate, free of adverse reactions and the like.The traditional Chinese medicine composition has functions of dispelling wind and removing obstruction in meridians and removing moisture and reducing phlegm, is short in treatment course, not prone to relapse, mild in medicine property, free of toxic and side effects, free of harms after long-term use, safe and reliable, and can be largely applied to clinical practice.
Description
Technical field
The present invention relates to a kind of medicinal preparation, particularly relate to a kind of for Chinese medicine composition treating allergic rhinitis and preparation method thereof.
Background technology
Nasal cavity is important respiratory apparatus and the organum olfactorium of human body.Allergic rhinitis is the disease of a series of allergic symptoms caused by respiratory tract because of physical property or chemical substance, concrete symptom is as follows: suddenly continuously sneeze, flow thin nasal discharge, have a stuffy nose obstructed or have the symptoms such as rhinocnesmus, year of a specified duration, unhealed may result in allergic asthma, concurrent core pulmonale and right heart failure then.
Allergic rhinitis is one of the commonly encountered diseases of China each department people, frequently-occurring disease.Patient's nasal cavity dysfunction time serious, loses autonomous respiration ability.Currently, seeking the medicine of the little treatment allergic rhinitis of efficient, quick, safety, side effect is extremely urgent task.
Therefore, allergic rhinitis treat field need badly a kind of good effect is provided, cost is low, cure rate is high, have no adverse reaction, expelling pathogenic wind and restoring the functions of orifices in face, dehumidifying are reduced phlegm, short treating period, not easily recurrence, mild in medicine property and, have no side effect, clothes are without the Chinese medicine composition of fraud, safe and reliable, the treatment allergic rhinitis that can apply in a large number in clinical practice for a long time.
Summary of the invention
In order to solve the problems referred to above, the present invention provides that a kind of good effect, cost are low, cure rate is high, has no adverse reaction, expelling pathogenic wind and restoring the functions of orifices in face, dehumidifying are reduced phlegm, short treating period, not easily recurrence, mild in medicine property and, have no side effect, clothes are without the Chinese medicine composition of fraud, safe and reliable, the treatment allergic rhinitis that can apply in a large number in clinical practice for a long time.
The technical solution used in the present invention is: described in a kind of Chinese medicine composition treating allergic rhinitis, each component of Chinese medicine composition is Herba Ephedrae, Rhizoma Acori Graminei, Radix Aconiti Preparata, Cortex Mori, Rhizoma Pinelliae, the Radix Angelicae Dahuricae；
Further, the ratio of weight and number of various components is Herba Ephedrae 5-15 part, Rhizoma Acori Graminei 5-15 part, Radix Aconiti Preparata 5-15 part, Cortex Mori 5-15 part, Rhizoma Pinelliae 5-15 part, Radix Angelicae Dahuricae 10-20 part；
Further, the ratio of weight and number of various components is Herba Ephedrae 5-10 part, Rhizoma Acori Graminei 5-10 part, Radix Aconiti Preparata 5-10 part, Cortex Mori 5-10 part, Rhizoma Pinelliae 5-10 part, Radix Angelicae Dahuricae 10-15 part；
Further, described Chinese medicine also includes Flos micheliae Albae 5-10 part, Radix Astragali 5-10 part；
Further, the dosage form of described Chinese medicine composition is: powder.
The preparation method that present invention also offers the Chinese medicine composition of above-mentioned treatment allergic rhinitis, when the dosage form of described Chinese medicine is powder, concrete steps include:
Being dried by each crude drug, the processing of each crude drug pulverized respectively with pulverizer, 80-100 order sieves, in proportion bag distribution packaging, stores in shady and cool ventilation dries when.
Herba Ephedrae, the cold expelling that induces sweat, depressed lung-energy dispersing, logical nine orifices, loosing the interspaces of skin and muscles.
Rhizoma Acori Graminei, expelling wind and removing dampness, by expectorant removing food stagnancy, activating YANG to wake up the patient from unconciousness.
Cortex Mori, dredging water passages, profit large intestine, lung qi dyspnea with fullness of the chest, steam edema, because of the lung and the large intestine being interior-exteriorly related, the allergic asthma that allergic rhinitis is concurrent can be treated.
Radix Aconiti Preparata, searches wind prevailing over dampness, chases after wind and invigorates blood circulation.
The Radix Angelicae Dahuricae, gas warm in nature is thick, and fragrance is up to, and property is kind dispels the wind, sensible row table.
Rhizoma Pinelliae, lung heat clearing, drying dampness to eliminate phlegm.
Flos micheliae Albae, bitter in the mouth, pungent, slightly warm in nature, removing dampness by means of aromatics, diuresis, relieving cough and resolving phlegm.
The Radix Astragali, sweet in the mouth, warm in nature, return lung, spleen channel, invigorating QI to consolidate the body surface resistance.
Beneficial effects of the present invention:
Relative to the medicine with treatment allergic rhinitis effect of the prior art, adopt the advantages such as this kind of Chinese medicine composition has good effect in treatment allergic rhinitis, cost is low, cure rate is high, have no adverse reaction.The Chinese medicine composition expelling pathogenic wind and restoring the functions of orifices in face of the present invention, dehumidifying reduce phlegm, short treating period, not easily recur, mild in medicine property and, have no side effect, clothes are without fraud for a long time, safe and reliable, can apply in clinical practice in a large number.
The Chinese medicine composition of the present invention is also fine with the clinical therapeutic efficacy of card for different disease, hypertrophic inferior turbinate, deviation of nasal septum and Nasal Polyps Patients, the same allergic rhinitis symptoms of its clinical symptoms, additionally, the patient throughout the year crossed with Western medicine nasal drop collunarium and use aerosol therapy, may result in nasal mucosa atrophy, affect permeability and the gas exchange of intraor extracellular, above disease is also effective, but can not thorough treatment.So must be that simple Allergic Rhinitis can be only achieved therapeutic purposes.It addition, this medicine can play beyond thought good effect equally for the patient of the common cold initial stage of affection of exogenous wind-cold exterior deficiency syndrome, stuffy nose with watery discharge.
Above a few herbs, through reasonable compatibility, science is concocted, extraction and cleaning, the merit sensible to reach expelling wind and removing dampness, refreshment, recovers the gaseous metabolism of lung and nose, adjusts waterway, and the normal water liquid of through lung and kidney regulates, to reach the purpose treated.
Detailed description of the invention
Embodiment 1:
(1) a kind of Chinese medicine treating allergic rhinitis, is formed by following raw material medicaments in part by weight proportioning:
10 parts of Herba Ephedrae, Rhizoma Acori Graminei 10 parts, Radix Aconiti Preparata 10 parts, Cortex Mori 10 parts, Rhizoma Pinelliae 10 parts, the Radix Angelicae Dahuricae 15 parts.
(2) preparation method:
Being dried by each crude drug, the processing of each crude drug pulverized respectively with pulverizer, 80-100 order sieves, in proportion bag distribution packaging, stores in shady and cool ventilation dries when.
(3) using method:
Prepare little binder one volume, Oleum sesami, toothpick.Take appropriate medicated powder, dip in a little Oleum sesami with toothpick, mixing, cut binder one blockage, put the medicated powder mixed up, wrap up with line, plug side, nostril or bilateral, reserve the clear snot of volume, continue beyond the Great Wall after cleaning after ten minutes, not intermittent use, plug is put continuously, until nose ventilation, not flowing clear snot just can drug withdrawal, it is considered as curing, if runny nose is a lot, one day replaceable one to twice.
Taboo: avoid pungent food during medication, raw meat, stimulation food.
Embodiment 2:
(1) a kind of Chinese medicine treating allergic rhinitis, is formed by following raw material medicaments in part by weight proportioning:
10 parts of Herba Ephedrae, Rhizoma Acori Graminei 10 parts, Radix Aconiti Preparata 10 parts, Cortex Mori 10 parts, Rhizoma Pinelliae 10 parts, the Radix Angelicae Dahuricae 15 parts, Flos micheliae Albae 5 parts, the Radix Astragali 5 parts.
(2) preparation method:
Being dried by each crude drug, the processing of each crude drug pulverized respectively with pulverizer, 80-100 order sieves, in proportion bag distribution packaging, stores in shady and cool ventilation dries when.
(3) using method:
Prepare little binder one volume, Oleum sesami, toothpick.Take appropriate medicated powder, dip in a little Oleum sesami with toothpick, mixing, cut binder one blockage, put the medicated powder mixed up, wrap up with line, plug side, nostril or bilateral, reserve the clear snot of volume, continue beyond the Great Wall after cleaning after ten minutes, not intermittent use, plug is put continuously, until nose ventilation, not flowing clear snot just can drug withdrawal, it is considered as curing, if runny nose is a lot, one day replaceable one to twice.
Taboo: avoid pungent food during medication, raw meat, stimulation food.
Embodiment 3:
1, long term toxicity test process:
Experimental agents is set as high, medium and low three dosage by application Wistar rat (Beijing Vital River Experimental Animals Technology Co., Ltd.'s offer), respectively capsule 8g/kg, 4g/kg, 2g/kg of embodiment 2 formula.Calculate with dosage 0.1g/kg/ sky-backing by people, be 80 times of people's effective dose, 40 times and 20 times respectively；Separately set a matched group, after continuous gastric infusion 90 days, 180 days and Some Animals drug withdrawal 10 days, observe the impact on the every physiology of rat, biochemical indicator.Test result indicate that: by various dose to rat continuous oral 180 days, food-intake and body weight on rat increase all without affecting.Hepatic and renal function is not all found overt toxicity effect.Routine blood test, blood biochemistry, urine biochemistry and bone marrow sheet etc. are showed no and significantly affect, between each group, compare no significant difference with matched group.
2, acute toxicity test process:
Application ICR mice (Beijing Vital River Experimental Animals Technology Co., Ltd.'s offer) 40, body weight, at 25-30 gram, carries out acute toxicity testing.Mice is randomly divided into two groups, namely matched group, administration group, fasting 12 hours before experiment, the Chinese medicine capsules suspension of the present invention then giving to prepare such as embodiment 2 (capsule is dissolved in water acquisition suspension) gavage, the median lethal dose(LD 50) (LD to administration50) carry out test determination, but do not measure LD50, therefore carried out mtd test.Result: with Cmax (60%), maximum dosage-feeding (120ml/kg, in one day, part gives for four times) 100g/kg gavage, be equivalent to crude drug amount 60g/kg, be equivalent to clinical 300 times (by the 75kg) intending daily dosage that are grown up, none death of mice in seven days, puts to death each internal organs of mice anatomic observation and does not find toxic reaction, and administration group and control group mice are without any difference.
Embodiment 4:
The clinical treatment observation of the present invention is as follows:
(1) patient 210 example, wherein 110 examples are male, and 100 examples are women.
(2) diagnostic criteria:
1, with nasal obstruction, sneeze repeatedly, stream clear water sample or mucus nasal mucus for cardinal symptom, with feeling of fullness in the head, headache；
2, nasal cavity inspection: nasal decongestion, concha nasalis enlargement, nasal cavity secretions increase.
(3) Therapeutic Method: 1 group: adopting the powder 100g as embodiment 1 preparation method prepares, be divided into 10 parts, every morning uses portion, 10 days is a course for the treatment of, takes two courses for the treatment of continuously；2 groups: adopting the powder 100g as embodiment 2 preparation method prepares, be divided into 10 parts, every morning uses portion, within 10 days, is a course for the treatment of, takes two courses for the treatment of continuously；Separately set a matched group.
(4) efficacy assessment standard:
Criterion of therapeutical effect:
Overall efficacy evaluation is with reference to " new Chinese medicine guideline of clinical investigations " relevant criterion:
Cure: whole body and local symptom and sign disappear；
Effective: whole body and local symptom and sign have clear improvement or have improvement；
Invalid: symptom and sign are not improved.
(5) therapeutic outcome is shown inTable 1:
Table 1Therapeutic outcome
| Group | Recovery from illness | Effectively | Invalid |
| Matched group | 0 | 0 | 70 |
| 1 group | 68 | 1 | 1 |
| 2 groups | 69 | 1 | 0 |
(6) case summary:
1, grandson patient: female, at 46 years old age, season in spring and autumn is to pollen hypersensitivity whenever, causes nasal obstruction obstructed, and stream thin nasal discharge, sneeze repeatedly, ill more than 10 years, are treated about 20 days with this medicine, and above symptom is wholly absent, and follows up a case by regular visits to and does not recur for more than 2 years.
2, Wang: man, at 16 years old age, suffers from allergic rhinitis more than 5 years, rise morning every day chance cold, continuous sneeze, stream thin nasal discharge, rhinocnesmus, because of attend class can not every day continuous use, classes are over and the time break medication such as festivals or holidays, cured completely through about 20 days, follows up a case by regular visits to 3 years and do not recur.
3, Zhang: female, 60 years old, suffers from more than 20 years of allergic rhinitis, through treating nearly one month, cures completely, follows up a case by regular visits to 5 years and do not recur.
4, morning so-and-so: man, 28 years old, Hok-lo, bridegroom's or husband's side dampness weight, temperature were high, to damp-heat air allergy, flow clear snot throughout the year, and sneeze repeatedly, affect normal operation, seeks medical advice from network, then posts this medicine one box, through timely medication, within nearly one month, fully recover, follow up a case by regular visits to and do not recur for many years.
5, king so-and-so: female, 48 years old, its son 18 years old, student, suffer from allergic rhinitis 2 years, intermittent treatment fully recover after one month, has now worked and has not recurred so far, by often purchasing medicine to Henan, native place friend, successively purchased medicine more than 50 box, cure rate 100%.
6, teacher Li in Qingdao two: allergic rhinitis buys 5 boxes on behalf for other five teachers again after curing, through following up a case by regular visits to whole healing.
7, Zhang: female, 42 years old, people from Laiwu, finds the professional presentations of this medicine from " Traditional Chinese Medicine " magazine, and Please ring for assistance, it is to cold air allergy, ill 6 years and with allergic asthma, fast drug delivery one box, treated through one week, allergic rhinitis and allergic asthma are cured simultaneously, and send picture and express thanks.
8, certain snow: female, 22 years old, to dust, or to acarid allergy, suffer from allergic rhinitis 3 years, 3 purchase medicine one bag, through treatment recovery from illness in 20 days, then purchase medicine 6 bags for friend again, all cure through following up a case by regular visits to.
9, weighing certain: female, doctor, Shanghai relatives suffer from allergic rhinitis for many years, then post this medicine one bag, just send wechat next day, very pleased, medication one day, and nose ventilation on that night, sleep quality improves, medication about 20 days, recovery from illness.
10, Wang: man, its female Zhang Xiulan, after healing; household is very pleased, because it is company manager, and resident Japan; Flos Pruni yedoensis is a lot; the people of pollen hypersensitivity is a lot, and every spring, pollen four was raised, and migrant person must band mask; so; come back home every year and be on home leave, before leaving, band is treated the medicine bag up to a hundred of allergic rhinitis.
We belong to secret prescription handed down in the family from generation to generation, sheerly Chinese medicine preparation, without any side effects, are adapted to the allergic rhinitis that a variety of causes causes, and processing technology is simple, and easy to use, all different crowds all can use, and are the domestic and international extensive patients good medicine that is prone to accept.
Above-described embodiment, simply to illustrate that the technology of the present invention is conceived and feature, its objective is to be in that to allow one of ordinary skilled in the art will appreciate that present disclosure and to implement according to this, can not limit the scope of the invention with this.The change of every equivalence done by the essence of present invention or modification, all should be encompassed in protection scope of the present invention.
Claims (6)
1. the Chinese medicine composition treating allergic rhinitis, it is characterised in that: each component of described Chinese medicine composition is Herba Ephedrae, Rhizoma Acori Graminei, Radix Aconiti Preparata, Cortex Mori, Rhizoma Pinelliae, the Radix Angelicae Dahuricae..
2. Chinese medicine composition as claimed in claim 1, it is characterised in that: the ratio of weight and number of various components is Herba Ephedrae 5-15 part, Rhizoma Acori Graminei 5-15 part, Radix Aconiti Preparata 5-15 part, Cortex Mori 5-15 part, Rhizoma Pinelliae 5-15 part, Radix Angelicae Dahuricae 10-20 part.
3. Chinese medicine composition as claimed in claim 1, it is characterised in that: the ratio of weight and number of various components is Herba Ephedrae 5-10 part, Rhizoma Acori Graminei 5-10 part, Radix Aconiti Preparata 5-10 part, Cortex Mori 5-10 part, Rhizoma Pinelliae 5-10 part, Radix Angelicae Dahuricae 10-15 part.
4. the Chinese medicine composition as according to any one of claim 1-3, it is characterised in that: described Chinese medicine also includes Flos micheliae Albae 5-10 part, Radix Astragali 5-10 part.
5. as according to any one of claim 1-4, treat the Chinese medicine composition of allergic rhinitis, it is characterised in that the dosage form of described Chinese medicine composition is: powder.
6. the preparation method of the Chinese medicine composition treating allergic rhinitis as according to any one of claim 1-4, it is characterised in that: when the dosage form of described Chinese medicine is powder, including:
Being dried by each crude drug, the processing of each crude drug pulverized respectively with pulverizer, 80-100 order sieves, in proportion bag distribution packaging, stores in shady and cool ventilation dries when.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618640A (en) * | 2021-01-20 | 2021-04-09 | 周桂兰 | Traditional Chinese medicine for treating allergic rhinitis by dredging orifices and removing dampness and using method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1099277A (en) * | 1993-08-21 | 1995-03-01 | 刘文英 | Rhinitis drops and its preparation |
| CN102205106A (en) * | 2011-05-20 | 2011-10-05 | 济南金鼎信息技术有限公司 | Chinese medicinal composition for treating allergic rhinitis |
| CN102526681A (en) * | 2012-02-20 | 2012-07-04 | 钟弦 | Traditional Chinese medicinal composition for treating allergic rhinitis |
-
2016
- 2016-02-19 CN CN201610110798.4A patent/CN105770260A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1099277A (en) * | 1993-08-21 | 1995-03-01 | 刘文英 | Rhinitis drops and its preparation |
| CN102205106A (en) * | 2011-05-20 | 2011-10-05 | 济南金鼎信息技术有限公司 | Chinese medicinal composition for treating allergic rhinitis |
| CN102526681A (en) * | 2012-02-20 | 2012-07-04 | 钟弦 | Traditional Chinese medicinal composition for treating allergic rhinitis |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618640A (en) * | 2021-01-20 | 2021-04-09 | 周桂兰 | Traditional Chinese medicine for treating allergic rhinitis by dredging orifices and removing dampness and using method thereof |
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