CN1099277A

CN1099277A - Rhinitis drops and its preparation

Info

Publication number: CN1099277A
Application number: CN 93116469
Authority: CN
Inventors: 刘文英
Original assignee: Individual
Current assignee: Individual
Priority date: 1993-08-21
Filing date: 1993-08-21
Publication date: 1995-03-01
Anticipated expiration: 2013-08-21
Also published as: CN1048880C

Abstract

The nose drops are prepared by mixing and smashing herba asari, flower bud of magnolia, plant soot, calamus, mulberry bark, honeylocust and ephedra, soaking with distilled water and filtering, then mixing the filtrate with camphor in alcohol solution, and adding a small amount of musk, it is used for treatment and prevention of dizziness, headache, rhinorrhea caused by acute and chronic rhinitis, rhinoantritis.

Description

Rhinitis drops and its preparation

The present invention relates to a kind of medicine for the treatment of rhinitis, particularly a kind ofly be mainly used in that treatment and prevention acute or chronic rhinitis, the caused giddy of sinusitis, headache, nasal obstruction are obstructed, the drop of watery nasal discharge etc.

The breathing of lung is had one's ideas straightened out in nose, and nose is the door of breathing.The nasal disease kind is more, and the most commonly acute or chronic rhinitis, sinusitis, cardinal symptom are that dizzy, headache, nasal obstruction are obstructed, watery nasal discharge etc., and rhinitis patient easily catches a cold, and suffers from rhinitis, all makes troubles for life, work, obstinate, consequence is with even more serious.The method of treatment rhinitis is divided two kinds of Drug therapy and operative treatments; Operative therapy is painful big, wound is arranged, be difficult for being accepted by the patient, therefore people adopt pharmacotherapy more, and medicine commonly used has BIYANKANG, HUODAN WAN and naphazoline etc., and naphazoline is the solution of naphcon, as drop the vasoconstrictive effect is arranged, be used for rhinitis, nasal congestion, the effect of paying is very big, and life-time service may cause atrophic rhinitis etc., also have a lot of taboos, use is restricted.BIYANKANG, HUODAN WAN two side's principal agents are identical, are Radix agastaches, Fel Sus domestica, are the oral medicine class, and they are obstructed to the treatment nasal obstruction, watery nasal discharge etc. has certain effect, but they are only with heat-clearing and toxic substances removing, and it is sensible to decide lung, and promoting blood circulation and detumescence is a principle, can not fundamentally cure.

The object of the present invention is to provide a kind of phinamide of pure Chinese medicine.Be a kind of no pain, no wound, old, children's all can use, and nontoxic, pair effect, fundamentally treats the medicine of rhinitis.

The present invention also aims to provide a kind of preparation method of phinamide.

The objective of the invention is to realize in the following manner.

The active ingredient of phinamide of the present invention is the leaching liquid of following material, and material consists of: Herba Asari, Flos Magnoliae, Pulvis Fumi Carbonisatus, Rhizoma Acori Graminei, Cortex Mori.

Also can comprise Fructus Gleditsia, Herba Ephedrae in the material, also can add a small amount of Camphora in the leaching liquid, also can add a small amount of Moschus in the leaching liquid.

Material composition of the present invention is with the pharmacology of these raw materials and definite through testing in a large number.With Herba Ephedrae, the hot warm cold expelling of Herba Asari is we's main batching, and Moschus, Flos Magnoliae, Fructus Gleditsia, Rhizoma Acori Graminei, Camphora consciousness restoring are auxilliary, Cortex Mori, Pulvis Fumi Carbonisatus heat-clearing and toxic substances removing, and the profit of holding concurrently is closed key and is ended nose bleeding, in order to restrain the hot dry too for helping of Herba Ephedrae, Herba Asari etc.

Particularly the composition of phinamide of the present invention have following several, with reference to ratio following (weight ratio):

Herba Asari: Pulvis Fumi Carbonisatus: Flos Magnoliae: Rhizoma Acori Graminei: Cortex Mori=1: 1: 0.5-2: 0.05-0.2: 0.5-2; Or

Herba Asari: Pulvis Fumi Carbonisatus: Flos Magnoliae: Rhizoma Acori Graminei: Cortex Mori: Fructus Gleditsia: Herba Ephedrae=1: 1: 0.5-2: 0.05-0.2: 0.5-2: 0-0.05: 0.1-0.2.

Above two kinds to cooperate the leaching liquid of compositions promptly be the most basic formation of phinamide of the present invention.In addition, also can add the Camphora of 0-0.02 in the leaching liquid, addition is the reference ratio (weight ratio) with above-mentioned composition mode.

Add a small amount of Moschus in the leaching liquid, addition is approximately the 0-0.002(weight ratio generally with reference to other inventory).

Above each component ratio all refers to weight ratio.

The preparation method of phinamide of the present invention is as follows:

The Flos Magnoliae of use level, Herba Asari, Pulvis Fumi Carbonisatus, Rhizoma Acori Graminei, Cortex Mori etc. being mixed pulverize, with distilled water immersion more than 50 ℃, carry out diafiltration again to get first liquid, also is phinamide of the present invention.

Further, Camphora is dissolved into second liquid with ethanol, and with above-mentioned first liquid mix homogeneously (third liquid), phinamide.

Moschus being ground to form fine flour be dissolved in the above-mentioned first liquid or third liquid, also is phinamide.

When leaching first liquid, can add Herba Ephedrae and Fructus Gleditsia in the material.

Phinamide provided by the present invention has been obtained comparatively ideal therapeutic effect in clinical practice.According to the 300 routine clinical practice statistics that complete case is arranged, 231 people that fully recover account for 71%, and 78 people that take a turn for the better account for 26%, and invalid 9 people account for 3%, and total effective rate is 97%.

Phinamide of the present invention uses no pain, no wound, and old, juvenile all can use, life-time service, and nontoxic, nothing is paid effect.

The following examples are in order to explanation the present invention.

Embodiment one:

Consisting of of phinamide: Herba Asari: Pulvis Fumi Carbonisatus: Flos Magnoliae: Rhizoma Acori Graminei: Cortex Mori=1: 1: 1: 0.1: 1.

Preparation:

The material of said ratio is ground into powdery,, again it is carried out diafiltration, get filtrate promptly with 60 ℃ of distilled water immersions 24 hours.

Embodiment two:

Consisting of of phinamide:

Herba Asari: Pulvis Fumi Carbonisatus: Flos Magnoliae: Rhizoma Acori Graminei: Cortex Mori: Fructus Gleditsia: Herba Ephedrae=1: 1: 1: 0.1: 1: 0.05: 0.1.

Preparation:

Above material is mixed by use level, is ground into powdery, with 70 ℃ of distilled water immersions 36 hours, diafiltration it, get filtrate promptly.

Embodiment three:

Consisting of of phinamide:

Herba Asari: Pulvis Fumi Carbonisatus: Flos Magnoliae: Rhizoma Acori Graminei: Cortex Mori: Fructus Gleditsia: Herba Ephedrae: Camphora: Moschus=1: 1: 1: 0.1: 1: 0.05: 0.1: 0.02: 0.002.

Preparation:

1, it is even to get the mixing of materials except that Camphora and Moschus of above-mentioned use level, is broken into powdery, with 60-80 ℃ of distilled water immersion 24 hours, diafiltration first liquid.

2, with the Camphora of use level with 50% ethanol dissolving becoming second liquid.

3, Jiang Jia, second liquid are mixed into third liquid, and stir.

4, the Moschus with use level is ground into fine flour, is dissolved in the first liquid that mixes or third liquid promptly.

The proportioning of the foregoing description is weight ratio.

Claims

1, a kind of phinamide is characterized in that its active ingredient comprises: Herba Asari, Pulvis Fumi Carbonisatus, Flos Magnoliae, Rhizoma Acori Graminei, Cortex Mori, forming weight ratio is 1: 1: 0.5-2: 0.05-0.2: 0.5-2.

2, by the described phinamide of claim 1, it is characterized in that also comprising Fructus Gleditsia and Herba Ephedrae, each components by weight is: Herba Asari: Pulvis Fumi Carbonisatus: Flos Magnoliae: Rhizoma Acori Graminei: Cortex Mori: Fructus Gleditsia: Herba Ephedrae=1: 1: 0.5-2: 0.05-0.2: 0.5-2: 0-0.05: 0.1-0.2.

3, by claim 1 or 2 described phinamides, it is characterized in that also comprising in the active ingredient Camphora, addition is the 0-0.02 part (weight ratio) with reference to ratio.

4, by claim 1 or 2 described phinamides, it is characterized in that also comprising in the active ingredient Moschus, addition is the 0-0.002 part (weight ratio) with reference to ratio.

5, by the described phinamide of claim 3, it is characterized in that also comprising in the active ingredient Moschus, add weight in 0-0.002 part (weight ratio) with reference to ratio.

6, a kind of preparation method of phinamide is characterized in that Flos Magnoliae, Herba Asari, Pulvis Fumi Carbonisatus, Rhizoma Acori Graminei, the Cortex Mori mixed material of use level are pulverized, and with the distilled water immersion more than 50 ℃, carries out diafiltration again, gets filtrate promptly.

7,, it is characterized in that adding in the material Herba Ephedrae and Fructus Gleditsia by the described method of claim 7.

8, by claim 6 or 7 described methods, it is characterized in that:

A, each mixing of materials of use level is pulverized,, carried out diafiltration again and get first liquid with distilled water immersion more than 50 ℃;

B, Camphora is dissolved into second liquid with ethanol;

C, a, b liquid are mixed into third liquid promptly.

9,, it is characterized in that Moschus is ground to form fine flour to be dissolved in the first liquid or third liquid promptly by the described method of claim 8.