CN105767587A - Traditional Chinese medicine microecological preparation for improving laying hen performance and preparation method of traditional Chinese medicine microecological preparation for improving laying hen performance - Google Patents
Traditional Chinese medicine microecological preparation for improving laying hen performance and preparation method of traditional Chinese medicine microecological preparation for improving laying hen performance Download PDFInfo
- Publication number
- CN105767587A CN105767587A CN201610278338.2A CN201610278338A CN105767587A CN 105767587 A CN105767587 A CN 105767587A CN 201610278338 A CN201610278338 A CN 201610278338A CN 105767587 A CN105767587 A CN 105767587A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- parts
- preparation
- strain
- medicine microecological
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 90
- 238000002360 preparation method Methods 0.000 title claims abstract description 81
- 239000009636 Huang Qi Substances 0.000 claims abstract description 32
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 28
- 150000004676 glycans Chemical class 0.000 claims abstract description 27
- 239000005017 polysaccharide Substances 0.000 claims abstract description 27
- 210000005253 yeast cell Anatomy 0.000 claims abstract description 26
- 239000002994 raw material Substances 0.000 claims abstract description 22
- 238000000855 fermentation Methods 0.000 claims abstract description 21
- 230000004151 fermentation Effects 0.000 claims abstract description 21
- 241000194108 Bacillus licheniformis Species 0.000 claims abstract description 20
- 244000063299 Bacillus subtilis Species 0.000 claims abstract description 20
- 235000014469 Bacillus subtilis Nutrition 0.000 claims abstract description 20
- 240000006024 Lactobacillus plantarum Species 0.000 claims abstract description 20
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims abstract description 20
- 229940072205 lactobacillus plantarum Drugs 0.000 claims abstract description 20
- 238000004519 manufacturing process Methods 0.000 claims description 53
- 241000287828 Gallus gallus Species 0.000 claims description 51
- 241000894006 Bacteria Species 0.000 claims description 41
- 241000194032 Enterococcus faecalis Species 0.000 claims description 19
- 229940032049 enterococcus faecalis Drugs 0.000 claims description 19
- 239000000843 powder Substances 0.000 claims description 17
- 239000012467 final product Substances 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 5
- 230000006870 function Effects 0.000 abstract description 15
- 229940079593 drug Drugs 0.000 abstract description 10
- 230000001976 improved effect Effects 0.000 abstract description 6
- 239000003640 drug residue Substances 0.000 abstract description 5
- 206010059866 Drug resistance Diseases 0.000 abstract description 4
- 231100000678 Mycotoxin Toxicity 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 4
- 230000036039 immunity Effects 0.000 abstract description 4
- 239000002636 mycotoxin Substances 0.000 abstract description 4
- 238000011109 contamination Methods 0.000 abstract description 3
- 230000001580 bacterial effect Effects 0.000 abstract description 2
- 241000194031 Enterococcus faecium Species 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 230000017448 oviposition Effects 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 235000013330 chicken meat Nutrition 0.000 description 43
- 230000000694 effects Effects 0.000 description 16
- 230000000968 intestinal effect Effects 0.000 description 15
- 239000000047 product Substances 0.000 description 12
- 230000002265 prevention Effects 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 7
- 230000036750 egg laying performance Effects 0.000 description 6
- 230000012010 growth Effects 0.000 description 6
- 239000006041 probiotic Substances 0.000 description 6
- 235000018291 probiotics Nutrition 0.000 description 6
- 238000010298 pulverizing process Methods 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 210000003734 kidney Anatomy 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 230000000529 probiotic effect Effects 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 229920002498 Beta-glucan Polymers 0.000 description 3
- 102000002322 Egg Proteins Human genes 0.000 description 3
- 108010000912 Egg Proteins Proteins 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 239000003674 animal food additive Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 3
- 238000009395 breeding Methods 0.000 description 3
- 230000001488 breeding effect Effects 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 210000003278 egg shell Anatomy 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 235000021050 feed intake Nutrition 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 230000036737 immune function Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000001850 reproductive effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000035882 stress Effects 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 239000003390 Chinese drug Substances 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- TZJALUIVHRYQQB-XFDQAQKOSA-N Icariin Natural products O(C)c1ccc(C2=C(O[C@H]3[C@@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)C(=O)c3c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)c(C/C=C(\C)/C)c3O2)cc1 TZJALUIVHRYQQB-XFDQAQKOSA-N 0.000 description 2
- 102000014150 Interferons Human genes 0.000 description 2
- 108010050904 Interferons Proteins 0.000 description 2
- 102000009151 Luteinizing Hormone Human genes 0.000 description 2
- 108010073521 Luteinizing Hormone Proteins 0.000 description 2
- 241000295644 Staphylococcaceae Species 0.000 description 2
- 230000003266 anti-allergic effect Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- TZJALUIVHRYQQB-UHFFFAOYSA-N icariine Natural products C1=CC(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(C)O2)O)C(=O)C2=C(O)C=C(OC3C(C(O)C(O)C(CO)O3)O)C(CC=C(C)C)=C2O1 TZJALUIVHRYQQB-UHFFFAOYSA-N 0.000 description 2
- 229940079322 interferon Drugs 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 239000002932 luster Substances 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 230000007721 medicinal effect Effects 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 235000013594 poultry meat Nutrition 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241001061264 Astragalus Species 0.000 description 1
- 108010001478 Bacitracin Proteins 0.000 description 1
- 108010062877 Bacteriocins Proteins 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- 241000186016 Bifidobacterium bifidum Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000005787 Cistanche Species 0.000 description 1
- 241000756943 Codonopsis Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000991587 Enterovirus C Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 229920000057 Mannan Polymers 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 102000003946 Prolactin Human genes 0.000 description 1
- 108010057464 Prolactin Proteins 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 235000006533 astragalus Nutrition 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229960003071 bacitracin Drugs 0.000 description 1
- 229930184125 bacitracin Natural products 0.000 description 1
- CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 230000003177 cardiotonic effect Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- RKLXDNHNLPUQRB-TVJUEJKUSA-N chembl564271 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]2C(C)SC[C@H](N[C@@H](CC(N)=O)C(=O)NC(=O)[C@@H](NC2=O)CSC1C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NC(=C)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@H]1NC(=O)C(=C\C)/NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]2NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@H]3N[C@@H](CC(C)C)C(=O)NC(=O)C(=C)NC(=O)CC[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC=4C5=CC=CC=C5NC=4)CSC3)C(O)=O)C(C)SC2)C(C)C)C(C)SC1)C1=CC=CC=C1 RKLXDNHNLPUQRB-TVJUEJKUSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- -1 demethyl icariin Chemical compound 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000020764 fibrinolysis Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000008217 follicular development Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- TZJALUIVHRYQQB-XLRXWWTNSA-N icariin Chemical compound C1=CC(OC)=CC=C1C1=C(O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)C(=O)C2=C(O)C=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C(CC=C(C)C)=C2O1 TZJALUIVHRYQQB-XLRXWWTNSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000002440 industrial waste Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000008944 intestinal immunity Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000000527 lymphocytic effect Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229940097325 prolactin Drugs 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 108010082567 subtilin Proteins 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000004233 talus Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/169—Plantarum
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a traditional Chinese medicine microecological preparation for improving laying hen performance and a preparation method of the traditional Chinese medicine microecological preparation for improving the laying hen performance. The traditional Chinese medicine microecological preparation is prepared from fermentative strains and raw materials by means of mixed fermentation, wherein the raw materials include, by weight, 15-20 parts of Radix Astragali, 7-10 parts of Herba Epimedii, 50-60 parts of Folium Artemisiae Argyi, 8-12 parts of Fructus Jujubae and 7-10 parts of yeast cell wall polysaccharide, and as for every 15-20 g of Radix Astragali, 10-15 mL of bacillus subtilis, 3-5 mL of bacillus licheniformis, 5-10 mL of lactobacillus plantarum and 20-25 mL of enterococcus faecium are added correspondingly. The traditional Chinese medicine microecological preparation has the advantages that the traditional Chinese medicine microecological preparation is high in drug utilization ratio and remarkable in efficacy and solves the problems of bacterial drug resistance, drug residue, contamination of mycotoxins to feed and the like, laying hen immunity and intestinal tract digestion-absorption functions are enhanced, egg laying rate of laying hens is increased while egg quality is improved, and elimination time is prolonged, so that the laying hen performance is improved on the whole.
Description
Technical field
The invention belongs to traditional Chinese medicine for livestock microbial ecological agent technical field, be specifically related to a kind of Chinese medicine microecological preparation for improving production performance of layer chicken, the preparation method also relating to a kind of Chinese medicine microecological preparation for improving production performance of layer chicken.
Background technology
Egg production is to weigh the important indicator of performance in layers, is also the key affecting breeding layer chicken economic benefit.Egg Production of Laying Hens enters middle and late stage, on the one hand, the Intervention of its internal secretion reproductive hormone day by day fails, various reproductive hormones such as follicule-stimulating hormone (FSH), interstitialcellstimulating hormone (ICSH) isoconcentration are gradually lowered, and follicular development has the prolactin level of direct repression constantly rise, causing that in egg fowl ovary, the growth promoter of follicle is suppressed gradually, ovulation amount reduces, and laying rate declines；On the other hand, the production of high intensity makes laying hen be in stress sensitive state, and the immunologic function of body, function of intestinal canal etc. reduce, and the sensitivity of pathogenic microorganism is improved, and sickness rate and death rate raise.
The method in the past solving the problems such as egg laying performance decline, sickness rate rising mainly adds antibiotic in feedstuff and drinking-water, but the interpolation of long-term, high-dose result in a lot of problem, as the generation of Resistant strain, egg drug residue exceed standard, cause serious environmental pollution and threaten the health of people.Chinese herbal medicine replaces antibiotic can effectively reduce drug residue problem in animal feeding process.
nullIn prior art，CN103704515B discloses a kind of feed additive for improving Layer Production Performance，It is made up of the raw medicinal material of following parts by weight: Herba Epimedii 10-20 part、Radix Morindae Officinalis 10-20 part、Herba Leonuri 15-25 part、Fructus Ligustri Lucidi 10-20 part、Flos Rosae Chinensis 10-20 part、Fructus Psoraleae 15-25 part、Radix Codonopsis 10-20 part、Radix Rehmanniae Preparata 15-20 part、Radix Angelicae Sinensis 10-20 part、Fructus Jujubae 10-20 part、Herba Cistanches 15-20 part、Semen Cuscutae 10-15 part、Fructus Lycii 10-20 part、Rhizoma Atractylodis Macrocephalae 10-20 part、Radix Astragali 10-20 part、Folium Artemisiae Argyi 10-20 part、Radix Glycyrrhizae 10-20 part、DAWANHUA 10-20 part、Swing skin ginseng 15-25 part、Stigma Croci 10-15 part、Fructus Aurantii 15-20 part and Herba Oryzae Reproductii 10-20 part；Its preparation method is to adopt twice water to carry rear merging filtrate, and concentration gets dry extract, and is crushed to less than 30 μm, it is thus achieved that feed additive powder.This feed additive improves Layer Production Performance to a certain extent, has pure natural, has no drug resistance, the advantage that toxic and side effects is little.
But, due to the restriction of the digestive system of laying hen, traditional Chinese herbal and crude drugs preparations exists that action effect is slow, utilization rate is low, the unconspicuous problem of medicinal effects；And the appearance of biofermentation traditional Chinese medicine technology, make the drug effect of Chinese herbal medicine be greatly improved, and show comparatively significantly effect gradually in prevention disease and raising production performance etc..
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine microecological preparation for improving production performance of layer chicken, absorbance is high, and medicinal effects is notable, it is possible to significantly improve the economic benefit of breeding layer chicken.
The preparation method that second purpose of the present invention is to provide a kind of Chinese medicine microecological preparation for improving production performance of layer chicken.
In order to realize object above, the technical solution adopted in the present invention is:
A kind of Chinese medicine microecological preparation for improving production performance of layer chicken, is made up of the raw material mixed fermentation of fermented bacterium and following parts by weight: the Radix Astragali 15～20 parts, Herba Epimedii 7～10 parts, Folium Artemisiae Argyi 50～60 parts, 8～12 parts of Fructus Jujubae, yeast cell wall polysaccharide 7～10 parts；The consumption of described fermented bacterium is: the Radix Astragali correspondence of every 15～20g adds Bacillus subtilis strain 10～15mL, Bacillus licheniformis strain 3～5mL, Lactobacillus plantarum strain 5～10mL, enterococcus faecalis strain 20～25mL.
Preferably, the described Chinese medicine microecological preparation for improving production performance of layer chicken, it is made up of the raw material mixed fermentation of fermented bacterium and following parts by weight: the Radix Astragali 18 parts, Herba Epimedii 7 parts, Folium Artemisiae Argyi 60 parts, 12 parts of Fructus Jujubae, yeast cell wall polysaccharide 10 parts；The consumption of described fermented bacterium is: the Radix Astragali correspondence of every 18g adds Bacillus subtilis strain 15mL, Bacillus licheniformis strain 3mL, Lactobacillus plantarum strain 5mL, enterococcus faecalis strain 25mL.
Described fermentation is solid fermentation.
The viable count of described Bacillus subtilis strain is (1.0～3.0) × 109CFU/mL, the viable count of Bacillus licheniformis strain is (1.0～3.0) × 109CFU/mL, the viable count of Lactobacillus plantarum strain is (1.0～5.0) × 108CFU/mL, the viable count of enterococcus faecalis strain is (1.0～5.0) × 108CFU/mL。
Preferably, the viable count of described Bacillus subtilis strain is 1.5 × 109CFU/mL, the viable count of Bacillus licheniformis strain is 2.0 × 109CFU/mL, the viable count of Lactobacillus plantarum strain is 1.0 × 108CFU/mL, the viable count of enterococcus faecalis strain is 4.0 × 108CFU/mL。
Wherein, the component content (mass percent) of described yeast cell wall polysaccharide is: protein≤35%, beta glucan 20%～40%, total sugar >=40%, moisture≤9%.
The Chinese medicine microecological preparation for improving production performance of layer chicken of the present invention, the characteristic of each raw material is as follows:
The Radix Astragali: warm in nature, sweet in the mouth；Return lung, spleen channel；There is tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, effect of promoting pus discharge and tissue regeneration strengthening.Modern pharmacological research shows, its Main Function composition is astragalus polysaccharides, flavone, saponin etc., and its Main Function has: strengthens normal heart and shrinks, and the heart of exhaustion is had cardiotonic, expands whole body peripheral vessel, improve microcirculation；Protect the liver and protect kidney, neutralize a toxin；Promote the growth of immune organ, improve the activity of immunocyte, improve the effect of vaccine immunity；Intestinal beneficial bacterium is had facilitation, improves intestinal microenvironment；Antiviral, it is possible to stimulate the generation of interferon, the pathogen such as escherichia coli are had inhibitory action.
Herba Epimedii: warm in nature, acrid in the mouth, sweet；Return liver, kidney channel；There is kidney invigorating and YANG supporting, expelling wind and removing dampness, effect of relieving cough and asthma.Modern pharmacological research shows, its Main Function composition is icariin, demethyl icariin etc., and its Main Function has: blood pressure lowering, improves microcirculation and hypoglycemic effect；Can promote and two-ways regulation immunologic function；Antibacterial, the antiinflammatory of energy, and inducement interferon, significantly inhibit effect to poliovirus；Promote bone growth, stop calcium loss, pre-preventing bone rarefaction；Still there are defying age, antioxidation, antineoplastic prospect.
Folium Artemisiae Argyi: warm in nature, bitter in the mouth, pungent；Return liver,spleen,kidney warp；There is warming the meridian for stopping bleeding, cold expelling regulating menstruation, antiabortive effect.Modern pharmacological research shows, its Main Function composition is volatile oil, has cineole, linalool etc., and its Main Function has: reduces capillary permeability, fibrinolysis, plays anastalsis；There is the effect of obvious antitussive, calmness and eliminating phlegm and relieving asthma；Staphylococcus aureus, beta hemolytic streptococcus and escherichia coli etc. are all killed or inhibitory action by antiallergic.
Fructus Jujubae: warm in nature, sweet in the mouth；Return spleen, stomach warp；There is invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, relax effect of the property of medicine.Modern study shows, its primary medicinal component is alkaloids, flavonoid, amino acids, organic acid and vitamin, can put on weight and muscular strength, protect the liver, antiallergic and sedation.
Yeast cell wall polysaccharide: the macromole carbohydrate polymer extracted from yeast cell wall, mainly has glucosan and mannan.Main Function has: the immunologic function of enhancing body, lymphocytic propagation in stimulating animal body, strengthens the action function of macrophage, natural killer cell；Promote the propagation of intestinal beneficial bacterium, regulate animal alimentary canal microecological balance, improve function of intestinal canal；Mycotoxin in feedstuff there is stronger adsorption；Prevention and adjuvant treatment of diseases, promote ill poultry rehabilitation, reduce antibiotic use.
Bacillus subtilis, Bacillus licheniformis: belong to aerobic-type antibacterial, can breed rapidly when aerobic, the oxygen consumed in environment causes anaerobic environment, and can produce to promote the beneficial bacteria factor of lactic acid bacteria, bifidobacterium growth, thus maintaining the superiority of the intrinsic bacterium of the intestinal such as lactic acid bacteria, bacillus bifidus, keep the balance of intestinal microenvironment；Sweat produces various enzyme, is conducive to fermentation substrate and the degraded of intestinal food, increases operation rate；Such as pathogenic microorganism is had inhibitory action to metabolite by subtilin, bacitracin；The generation of ammonia can be reduced, improve the environment of growth of animals or poultry.
Lactobacillus plantarum, enterococcus faecalis: belong to anaerobic type antibacterial, metabolic process produces organic acid and the digestive enzyme such as substantial amounts of acetic acid, propanoic acid, reducing gastrointestinal pH, contribute to activation and improve pepsic activity, sour environment can effectively suppress growth of pathogenic bacteria to breed；Escherichia coli, Salmonella etc. are had suppression or killing action by the lactein in metabolite；Improve intestinal microenvironment, stimulate the growth of intestinal immune tissue, improve intestinal immunity.
The Chinese medicine microecological preparation for improving production performance of layer chicken of the present invention, the Radix Astragali selected by raw material, Fructus Jujubae etc. are mainly QI invigorating qi-restoratives, protect the liver the Chinese medicine protecting kidney class, with four kinds of probiotic bacterias, Chinese medicine composition medicated powder is carried out solid fermentation, first, can effectively degrade Chinese medicinal plant cell wall, it is beneficial to the release of effective ingredient, utilization rate and the drug effect of medicine can be improved, reduce dosage；Secondly, fermentation probiotic bacteria strain and laying hen intestinal autochthonous flora are respectively provided with growth promoting function by the Radix Astragali, it is possible to improve the quantity of probiotic bacteria in this preparation, and improve laying hen intestinal microenvironment, promote intestinal microbial population balance；Finally, probiotic bacteria produces the metabolites such as organic acid, bacteriocin and vitamin during the fermentation, has biologic activity widely, the raising of Layer Production Performance is had facilitation.
The Chinese medicine microecological preparation for improving production performance of layer chicken of the present invention, adopts the Radix Astragali, Herba Epimedii, Folium Artemisiae Argyi, this 4 taste Chinese medicine of Fructus Jujubae to coordinate with yeast cell wall polysaccharide, utilizes fermented bacterium to make through solid fermentation.Side reuses Folium Artemisiae Argyi, warming the meridian for stopping bleeding, cold expelling regulating menstruation, antiabortive, improve eggshell, yolk color, improve egg size and also improve pouity dwelling place abnormal smells from the patient；The Radix Astragali, Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind；Herba Epimedii and the same use of the Radix Astragali, synergism each other, tonifying Qi and lifting yang, expelling wind and removing dampness, hidroschesis consolidating superficial resistance.The Chinese medicine microecological preparation prepared through probiotics fermention after each taste Chinese medicine and yeast cell wall polysaccharide composite, from the aspect of medication, improves the effect of former Chinese medicine, extends its action function and the problem solving drug residue and drug resistance after fermentation；From the aspect of nutrition, yeast cell wall polysaccharide component can absorbing mycotoxin, improve feed quality；Applying effect aspect from laying hen itself, improve the immunity of body, improve the balance of function that intestinal digests and assimilates and flora, its integral production efficiency is improved.
The Chinese medicine microecological preparation for improving production performance of layer chicken of the present invention, select 4 kinds and can improve blood circulation, slow down aging, improve the Chinese medicine of reproductive capability and immunocompetence, cooperation has feedstuff and takes off the polysaccharide of mould effect, utilize microbial solid fermentation technology Chinese herbal medicine, probiotic bacteria to be combined, make the Chinese medicine microecological preparation of a kind of fermented type.This Chinese medicine microecological preparation utilization ratio of drug is high, drug effect is notable, rapid-action, first solves the problem that Chinese traditional herbs action effect is slow, utilization rate is low；Secondly, it is possible to reduce antibiotic application, make bacterial drug resistance, drug residue and feedstuff are readily solved by problems such as mycotoxin contaminations；Finally, enhance immunity of layer chicken and intestinal digestive and absorptive functions so that it is body is in health status, and then improves the quality of laying rate of laying hen and egg, postpone the time of eliminating, reach on the whole to improve performance in layers, create the purpose of economic worth for breeding layer chicken industry.
The preparation method of a kind of above-mentioned Chinese medicine microecological preparation for improving production performance of layer chicken, after mixing including the raw material and fermented bacterium that take formula ratio, under 25～40 DEG C of conditions, sealed fermenting 7～30 days, to obtain final product.
Preferably, the preparation method of the described Chinese medicine microecological preparation for improving production performance of layer chicken, after mixing including the raw material and fermented bacterium that take formula ratio, under 32 DEG C of conditions, sealed fermenting 20 days, to obtain final product.
The Radix Astragali in described raw material, Herba Epimedii, Folium Artemisiae Argyi, Fructus Jujubae are pulverized in advance and cross 100～200 mesh sieves, obtain medicated powder standby.Gained medicated powder is mixed with yeast cell wall polysaccharide and fermented bacterium again and ferments.
Preferably, the Radix Astragali in described raw material, Herba Epimedii, Folium Artemisiae Argyi, Fructus Jujubae are pulverized in advance and cross 200 mesh sieves, obtain medicated powder standby.
Wherein, the component content (mass percent) of yeast cell wall polysaccharide used is: protein≤35%, beta glucan 20%～40%, total sugar >=40%, moisture≤9%.
The preparation method of the Chinese medicine microecological preparation for improving production performance of layer chicken of the present invention, is Chinese medicine, yeast cell wall polysaccharide are made through solid fermentation after mixing with fermented bacterium；The method is easy and simple to handle, and without harmful substances such as three industrial wastes after fermentation, utilization rate is high, and feasibility is good, it is adaptable to large-scale industrial production, has good application value.
The usage of the Chinese medicine microecological preparation for improving production performance of layer chicken of the present invention is: when prevention performance in layers reduces, feedstuff per ton adds this product 2000g, is used in conjunction 7～10 days every time, every 10～15 days repeated drug takings once；Treatment performance in layers reduce time, feedstuff per ton adds this product 4000g, within 7～10 days, is a course for the treatment of, each course for the treatment of 3 days, interval.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further illustrated.
In detailed description of the invention, the component content (mass percent) of yeast cell wall polysaccharide used is: protein≤35%, beta glucan 20%～40%, total sugar >=40%, moisture≤9%.
Embodiment 1
The Chinese medicine microecological preparation for improving production performance of layer chicken of the present embodiment, is made up of the raw material mixed fermentation of fermented bacterium and following parts by weight: the Radix Astragali 15 parts, Herba Epimedii 7 parts, Folium Artemisiae Argyi 50 parts, 8 parts of Fructus Jujubae, yeast cell wall polysaccharide 7 parts；The consumption of described fermented bacterium is: the Radix Astragali correspondence of every 15g adds Bacillus subtilis strain 10mL, Bacillus licheniformis strain 3mL, Lactobacillus plantarum strain 5mL, enterococcus faecalis strain 20mL.
Wherein, the viable count of described Bacillus subtilis strain is 1.0 × 109CFU/mL, the viable count of Bacillus licheniformis strain is 3.0 × 109CFU/mL, the viable count of Lactobacillus plantarum strain is 1.0 × 108CFU/mL, the viable count of enterococcus faecalis strain is 5.0 × 108CFU/mL。
The preparation method of the Chinese medicine microecological preparation for improving production performance of layer chicken of the present embodiment is: crosses 100 mesh sieves after taking the former material pulverizing of Chinese medicine of formula ratio, obtains medicated powder；After being mixed homogeneously with yeast cell wall polysaccharide and fermented bacterium by gained medicated powder, under 25 DEG C of conditions, sealed fermenting 30 days, to obtain final product.
The usage of the Chinese medicine microecological preparation for improving production performance of layer chicken of the present embodiment is: when prevention performance in layers reduces, feedstuff per ton adds this product 2000g, is used in conjunction 7～10 days every time, every 10～15 days repeated drug takings once；Treatment performance in layers reduce time, feedstuff per ton adds this product 4000g, within 7～10 days, is a course for the treatment of, each course for the treatment of 3 days, interval.
Embodiment 2
The Chinese medicine microecological preparation for improving production performance of layer chicken of the present embodiment, is made up of the raw material mixed fermentation of fermented bacterium and following parts by weight: the Radix Astragali 20 parts, Herba Epimedii 10 parts, Folium Artemisiae Argyi 60 parts, 12 parts of Fructus Jujubae, yeast cell wall polysaccharide 10 parts；The consumption of described fermented bacterium is: the Radix Astragali correspondence of every 20g adds Bacillus subtilis strain 15mL, Bacillus licheniformis strain 5mL, Lactobacillus plantarum strain 10mL, enterococcus faecalis strain 25mL.
Wherein, the viable count of described Bacillus subtilis strain is 3.0 × 109CFU/mL, the viable count of Bacillus licheniformis strain is 1.0 × 109CFU/mL, the viable count of Lactobacillus plantarum strain is 5.0 × 108CFU/mL, the viable count of enterococcus faecalis strain is 1.0 × 108CFU/mL。
The preparation method of the Chinese medicine microecological preparation for improving production performance of layer chicken of the present embodiment is: crosses 120 mesh sieves after taking the former material pulverizing of Chinese medicine of formula ratio, obtains medicated powder；After being mixed homogeneously with yeast cell wall polysaccharide and fermented bacterium by gained medicated powder, under 40 DEG C of conditions, sealed fermenting 7 days, to obtain final product.
The usage of the Chinese medicine microecological preparation for improving production performance of layer chicken of the present embodiment is: when prevention performance in layers reduces, feedstuff per ton adds this product 2000g, is used in conjunction 7～10 days every time, every 10～15 days repeated drug takings once；Treatment performance in layers reduce time, feedstuff per ton adds this product 4000g, within 7～10 days, is a course for the treatment of, each course for the treatment of 3 days, interval.
Embodiment 3
The Chinese medicine microecological preparation for improving production performance of layer chicken of the present embodiment, is made up of the raw material mixed fermentation of fermented bacterium and following parts by weight: the Radix Astragali 17 parts, Herba Epimedii 8 parts, Folium Artemisiae Argyi 55 parts, 10 parts of Fructus Jujubae, yeast cell wall polysaccharide 8 parts；The consumption of described fermented bacterium is: the Radix Astragali correspondence of every 17g adds Bacillus subtilis strain 13mL, Bacillus licheniformis strain 4mL, Lactobacillus plantarum strain 7mL, enterococcus faecalis strain 23mL.
Wherein, the viable count of described Bacillus subtilis strain is 2.0 × 109CFU/mL, the viable count of Bacillus licheniformis strain is 2.0 × 109CFU/mL, the viable count of Lactobacillus plantarum strain is 4.0 × 108CFU/mL, the viable count of enterococcus faecalis strain is 3.0 × 108CFU/mL。
The preparation method of the Chinese medicine microecological preparation for improving production performance of layer chicken of the present embodiment is: crosses 150 mesh sieves after taking the former material pulverizing of Chinese medicine of formula ratio, obtains medicated powder；After being mixed homogeneously with yeast cell wall polysaccharide and fermented bacterium by gained medicated powder, under 37 DEG C of conditions, sealed fermenting 15 days, to obtain final product.
The usage of the Chinese medicine microecological preparation for improving production performance of layer chicken of the present embodiment is: when prevention performance in layers reduces, feedstuff per ton adds this product 2000g, is used in conjunction 7～10 days every time, every 10～15 days repeated drug takings once；Treatment performance in layers reduce time, feedstuff per ton adds this product 4000g, within 7～10 days, is a course for the treatment of, each course for the treatment of 3 days, interval.
Embodiment 4
The Chinese medicine microecological preparation for improving production performance of layer chicken of the present embodiment, is made up of the raw material mixed fermentation of fermented bacterium and following parts by weight: the Radix Astragali 18 parts, Herba Epimedii 7 parts, Folium Artemisiae Argyi 60 parts, 12 parts of Fructus Jujubae, yeast cell wall polysaccharide 10 parts；The consumption of described fermented bacterium is: the Radix Astragali correspondence of every 18g adds Bacillus subtilis strain 15mL, Bacillus licheniformis strain 3mL, Lactobacillus plantarum strain 5mL, enterococcus faecalis strain 25mL.
Wherein, the viable count of described Bacillus subtilis strain is 1.5 × 109CFU/mL, the viable count of Bacillus licheniformis strain is 2.0 × 109CFU/mL, the viable count of Lactobacillus plantarum strain is 1.0 × 108CFU/mL, the viable count of enterococcus faecalis strain is 4.0 × 108CFU/mL。
The preparation method of the Chinese medicine microecological preparation for improving production performance of layer chicken of the present embodiment is: crosses 200 mesh sieves after taking the former material pulverizing of Chinese medicine of formula ratio, obtains medicated powder；After being mixed homogeneously with yeast cell wall polysaccharide and fermented bacterium by gained medicated powder, under 32 DEG C of conditions, sealed fermenting 20 days, to obtain final product.
The usage of the Chinese medicine microecological preparation for improving production performance of layer chicken of the present embodiment is: when prevention performance in layers reduces, feedstuff per ton adds this product 2000g, is used in conjunction 7～10 days every time, every 10～15 days repeated drug takings once；During treatment, feedstuff per ton adds this product 4000g, within 7～10 days, is a course for the treatment of, each course for the treatment of 3 days, interval.
Embodiment 5
The Chinese medicine microecological preparation for improving production performance of layer chicken of the present embodiment, is made up of the raw material mixed fermentation of fermented bacterium and following parts by weight: the Radix Astragali 15 parts, Herba Epimedii 7 parts, Folium Artemisiae Argyi 60 parts, 10 parts of Fructus Jujubae, yeast cell wall polysaccharide 10 parts；The consumption of described fermented bacterium is: the Radix Astragali correspondence of every 15g adds Bacillus subtilis strain 10mL, Bacillus licheniformis strain 5mL, Lactobacillus plantarum strain 10mL, enterococcus faecalis strain 25mL.
Wherein, the viable count of described Bacillus subtilis strain is 1.0 × 109CFU/mL, the viable count of Bacillus licheniformis strain is 1.5 × 109CFU/mL, the viable count of Lactobacillus plantarum strain is 3.0 × 108CFU/mL, the viable count of enterococcus faecalis strain is 2.0 × 108CFU/mL。
The preparation method of the Chinese medicine microecological preparation for improving production performance of layer chicken of the present embodiment is: crosses 200 mesh sieves after taking the former material pulverizing of Chinese medicine of formula ratio, obtains medicated powder；After being mixed homogeneously with yeast cell wall polysaccharide and fermented bacterium by gained medicated powder, under 30 DEG C of conditions, sealed fermenting 25 days, to obtain final product.
The usage of the Chinese medicine microecological preparation for improving production performance of layer chicken of the present embodiment is: when prevention performance in layers reduces, feedstuff per ton adds this product 2000g, is used in conjunction 7～10 days every time, every 10～15 days repeated drug takings once；Treatment performance in layers reduce time, feedstuff per ton adds this product 4000g, within 7～10 days, is a course for the treatment of, each course for the treatment of 3 days, interval.
Comparative example
The Chinese medicine preparation of this comparative example is made up of the raw material of following parts by weight: the Radix Astragali 18 parts, Herba Epimedii 7 parts, Folium Artemisiae Argyi 60 parts, 12 parts of Fructus Jujubae, yeast cell wall polysaccharide 10 parts；200 mesh sieves crossed by the former material of Chinese medicine after pulverizing, mix homogeneously and get final product.The same above-described embodiment of usage.
Experimental example
The Chinese medicine microecological preparation the improving production performance of layer chicken performance of preventing and treating in laying hen feeds that is used for of embodiment 1-5 gained is detected by this experimental example.
(1) in prevention laying rate reduction:
Within 2015, carry out contrast experiment in Hebi City laying hen field, Henan Province, 700 60 weeks laying hens of navigating are randomly divided into 7 groups, often group 100, organize the feedstuff of the 1-5 method feeding successively according to the embodiment 1-5 Chinese medicine microecological preparation containing embodiment 1-5, group 6 then feeding is containing the feedstuff of comparative example Chinese medicine preparation, and using method is identical with group 1-5's.Group 7 is blank group, the not any medicine of feeding.Recording the egg laying performance of laying hen after 1 week, continuously record 1 week, preventive effect is table 1 such as.
Table 1 is respectively organized preventive effect and is compared
(note: laying rate raising value is the laying rate absolute value with the difference of the laying rate of group 7 of group 1-6, egg size raising value is the average egg weight absolute value with the difference of group 7 average egg weights of group 1-6)
As it can be seen from table 1 compared with conventional Chinese drug-treated group and blank group, after taking the Chinese medicine microecological preparation of embodiment 1-5, the laying rate of laying hen does not improve in 5.28%-7.71% scope not etc., average egg production raising 6.48%；Egg size improves at 3.29-5.05g, and average egg weight improves 4.04g.Test result indicate that, the Chinese medicine microecological preparation of the present invention has remarkable result in prevention laying rate of laying hen reduction, egg laying performance decline.
Type testing example 1:2015 carries out contrast test in laying hen field, Neihuang County, Henan Province, 6000 65 weeks blue brown laying hens in sea are randomly divided into 2 groups, respectively test group and matched group, often group 3000, test group feeds the feedstuff of the Chinese medicine microecological preparation containing embodiment 3, and method method as described in Example 3 feeds；Matched group feeding Normal Goods feedstuff, feeding and management is scheduled for by field.The egg laying performance of laying hen is recorded, continuously record 1 week after 1 week.Result is as follows, the average egg production of test group and egg size respectively 83.26%, 65.21g, the average egg production of matched group and egg size respectively 72.68%, 61.63g.Compared with matched group, the average egg production of test group and egg size have been respectively increased 10.58%, 3.58g.
(2) in treatment performance in layers reduction:
Within 2015, in laying hen field, Neihuang County, Henan Province, the 48 blue brown laying hen sudden onset in week old seas, feed intake declines, and the mental status is deteriorated, laying rate decline 20%-30%, and eggshell is without color and luster, and broken egg, soft egg increases, and is the egg drop syndrome of chicken through Disease Diagnosis of Veterinary.Randomly selecting 700 sick chickens and be divided into 7 groups, often group 100, organize the feedstuff of the 1-5 method feeding successively according to the embodiment 1-5 Chinese medicine microecological preparation containing embodiment 1-5, group 6 then feeding is containing the feedstuff of comparative example Chinese medicine preparation, and using method is identical with group 1-5's.Group 7 is blank group, the not any medicine of feeding.Recording the egg laying performance of laying hen after 1 week, continuously record 1 week, therapeutic effect is table 2 such as.
The therapeutic effect that table 2 is respectively organized
(note: laying rate raising value, average egg weight raising value and residual egg rate decreasing value respectively organize the absolute value of the laying rate of 1-6, average egg weight and residual egg rate and the difference of the laying rate of group 7, average egg weight and residual egg rate)
From table 2 it can be seen that compared with conventional Chinese drug-treated group and blank group, after taking the Chinese medicine microecological preparation of embodiment 1-5, laying rate of laying hen does not improve in 17.71%-20.29% scope not etc., average egg production raising 19.03%；Egg size improves at 4.66-5.38g, and average egg weight improves 4.98g, and residual egg rate reduces at 3.71%-3.94%, average out to 3.84%.Result of the test shows, the Chinese medicine microecological preparation of the present invention has remarkable result in treatment Layer Production Performance decline.
Type testing example 2:2015 is in laying hen field, Shouguang county of Shandong Province, 35 week old are navigated laying hen sudden onset, feed intake declines, diarrhoea, indivedual chickens have cough with asthma symptom, and laying rate declines about 25%, egg size alleviates, eggshell is without color and luster, and broken egg, soft egg, abnormal-shape egg increase, and is reload suddenly to cause that the egg laying performance that stress cause declines through Disease Diagnosis of Veterinary.Adopting the Chinese medicine microecological preparation of embodiment 5, feedstuff per ton adds 4kg, is used in conjunction 4 days, and full group's laying hen disease disappears, and laying rate is recovered to premorbid, is about 87%, and egg size average out to 63.56g, residual egg rate is down to 2.3%.
Type testing example 3:2015 is in common chicken field, Taiqian County, Henan Province, 45 week old left and right chicken sudden onset, laying rate falls to approximately 40% from about 70%, full group's chicken spirit is depressed, through understanding the state of an illness, reason be mainly change in weather stress caused by, add feedstuff and caused chicken house to fall ill by mould contamination, the reason such as unclean of drinking water.Adopting the Chinese medicine microecological preparation of embodiment 4, feedstuff per ton adds 4kg, is used in conjunction 3 days, and full group's chicken spirit takes a turn for the better, and feed intake increases, and after 5 days, laying rate is recovered to premorbid, is about 70%, egg size average out to 50g.
Claims (8)
1. the Chinese medicine microecological preparation being used for improving production performance of layer chicken, it is characterised in that: it is made up of the raw material mixed fermentation of fermented bacterium and following parts by weight: the Radix Astragali 15～20 parts, Herba Epimedii 7～10 parts, Folium Artemisiae Argyi 50～60 parts, 8～12 parts of Fructus Jujubae, yeast cell wall polysaccharide 7～10 parts；The consumption of described fermented bacterium is: the Radix Astragali correspondence of every 15～20g adds Bacillus subtilis strain 10～15mL, Bacillus licheniformis strain 3～5mL, Lactobacillus plantarum strain 5～10mL, enterococcus faecalis strain 20～25mL.
2. the Chinese medicine microecological preparation for improving production performance of layer chicken according to claim 1, it is characterised in that: it is made up of the raw material mixed fermentation of fermented bacterium and following parts by weight: the Radix Astragali 18 parts, Herba Epimedii 7 parts, Folium Artemisiae Argyi 60 parts, 12 parts of Fructus Jujubae, yeast cell wall polysaccharide 10 parts；The consumption of described fermented bacterium is: the Radix Astragali correspondence of every 18g adds Bacillus subtilis strain 15mL, Bacillus licheniformis strain 3mL, Lactobacillus plantarum strain 5mL, enterococcus faecalis strain 25mL.
3. the Chinese medicine microecological preparation for improving production performance of layer chicken according to claim 1 and 2, it is characterised in that: the viable count of described Bacillus subtilis strain is (1.0～3.0) × 109CFU/mL, the viable count of Bacillus licheniformis strain is (1.0～3.0) × 109CFU/mL, the viable count of Lactobacillus plantarum strain is (1.0～5.0) × 108CFU/mL, the viable count of enterococcus faecalis strain is (1.0～5.0) × 108CFU/mL。
4. the Chinese medicine microecological preparation for improving production performance of layer chicken according to claim 3, it is characterised in that: the viable count of described Bacillus subtilis strain is 1.5 × 109CFU/mL, the viable count of Bacillus licheniformis strain is 2.0 × 109CFU/mL, the viable count of Lactobacillus plantarum strain is 1.0 × 108CFU/mL, the viable count of enterococcus faecalis strain is 4.0 × 108CFU/mL。
5. an as claimed in claim 1 preparation method for improving the Chinese medicine microecological preparation of production performance of layer chicken, it is characterised in that: after the raw material including taking formula ratio and fermented bacterium mixing, under 25～40 DEG C of conditions, sealed fermenting 7～30 days, to obtain final product.
6. the preparation method of the Chinese medicine microecological preparation for improving production performance of layer chicken according to claim 5, it is characterised in that: the raw material including taking formula ratio and after fermented bacterium mixing, under 32 DEG C of conditions, sealed fermenting 20 days, to obtain final product.
7. the preparation method of the Chinese medicine microecological preparation for improving production performance of layer chicken according to claim 5 or 6, it is characterised in that: the Radix Astragali in described raw material, Herba Epimedii, Folium Artemisiae Argyi, Fructus Jujubae are pulverized in advance and cross 100～200 mesh sieves, obtain medicated powder standby.
8. the preparation method of the Chinese medicine microecological preparation for improving production performance of layer chicken according to claim 7, it is characterised in that: the Radix Astragali in described raw material, Herba Epimedii, Folium Artemisiae Argyi, Fructus Jujubae are pulverized in advance and cross 200 mesh sieves, obtain medicated powder standby.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610278338.2A CN105767587B (en) | 2016-04-29 | 2016-04-29 | A kind of Chinese medicine microecological preparation and preparation method thereof for improving production performance of layer chicken |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610278338.2A CN105767587B (en) | 2016-04-29 | 2016-04-29 | A kind of Chinese medicine microecological preparation and preparation method thereof for improving production performance of layer chicken |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105767587A true CN105767587A (en) | 2016-07-20 |
| CN105767587B CN105767587B (en) | 2019-05-10 |
Family
ID=56399073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610278338.2A Expired - Fee Related CN105767587B (en) | 2016-04-29 | 2016-04-29 | A kind of Chinese medicine microecological preparation and preparation method thereof for improving production performance of layer chicken |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105767587B (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106191044A (en) * | 2016-08-05 | 2016-12-07 | 福建农林大学 | A kind of gene engineering method improving lactein plnK yield |
| CN106343262A (en) * | 2016-08-30 | 2017-01-25 | 武汉华扬动物药业有限责任公司 | Method for immune enhancing agent for raising procambarus clarkii and the preparing method thereof and application |
| CN106994157A (en) * | 2017-03-24 | 2017-08-01 | 哈尔滨中科生物工程有限公司 | A kind of herb fermenting preparation, its preparation method and application for improving performance in layers |
| CN107467404A (en) * | 2017-10-23 | 2017-12-15 | 潍坊华光数码设备有限公司 | A kind of feed addictive for laying hen health care and preparation method thereof |
| CN108576479A (en) * | 2018-05-17 | 2018-09-28 | 杨凌职业技术学院 | A kind of feed addictive of layer chicken and preparation method thereof |
| CN110338141A (en) * | 2019-07-17 | 2019-10-18 | 湖北华大瑞尔科技有限公司 | A kind of application of the whole process nonreactive cultural technique scheme in breeding layer chicken |
| CN110463856A (en) * | 2019-09-05 | 2019-11-19 | 广东驱动力生物科技股份有限公司 | A kind of feed addictive improving Layer Production Performance |
| CN113080335A (en) * | 2021-05-18 | 2021-07-09 | 郑州赛科药业科技有限公司 | Fermented traditional Chinese medicine additive for improving egg poultry production performance and preparation method thereof |
| CN114617202A (en) * | 2022-03-29 | 2022-06-14 | 江苏三仪生物工程有限公司 | Compound microecological preparation for improving disease resistance and production performance of ducks as well as preparation method and application of compound microecological preparation |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104161206A (en) * | 2013-07-17 | 2014-11-26 | 河南联合英伟饲料有限公司 | Feed additive for increasing egg yield of hens and preparation method thereof |
| CN104171421A (en) * | 2014-08-08 | 2014-12-03 | 河南牧翔动物药业有限公司 | Feed additive for conditioning intestines of animals |
| CN104739919A (en) * | 2015-03-30 | 2015-07-01 | 山东宝来利来生物工程股份有限公司 | Fermented astragalus composite preparation as well as preparation method and application thereof |
| CN105053593A (en) * | 2015-07-15 | 2015-11-18 | 北京生泰尔科技股份有限公司 | Traditional Chinese medicine residues prepared poultry feed additive and preparation method thereof |
| CN105076864A (en) * | 2015-09-14 | 2015-11-25 | 石家庄维尔利动物药业有限公司 | Compound preparation used for improving quality of egg shells and preparation method of compound preparation |
| CN105146205A (en) * | 2013-08-20 | 2015-12-16 | 沈阳科丰牧业科技有限公司 | Method for improving broiler chicken production performance by means of microecological preparations for broiler chickens |
-
2016
- 2016-04-29 CN CN201610278338.2A patent/CN105767587B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104161206A (en) * | 2013-07-17 | 2014-11-26 | 河南联合英伟饲料有限公司 | Feed additive for increasing egg yield of hens and preparation method thereof |
| CN105146205A (en) * | 2013-08-20 | 2015-12-16 | 沈阳科丰牧业科技有限公司 | Method for improving broiler chicken production performance by means of microecological preparations for broiler chickens |
| CN104171421A (en) * | 2014-08-08 | 2014-12-03 | 河南牧翔动物药业有限公司 | Feed additive for conditioning intestines of animals |
| CN104739919A (en) * | 2015-03-30 | 2015-07-01 | 山东宝来利来生物工程股份有限公司 | Fermented astragalus composite preparation as well as preparation method and application thereof |
| CN105053593A (en) * | 2015-07-15 | 2015-11-18 | 北京生泰尔科技股份有限公司 | Traditional Chinese medicine residues prepared poultry feed additive and preparation method thereof |
| CN105076864A (en) * | 2015-09-14 | 2015-11-25 | 石家庄维尔利动物药业有限公司 | Compound preparation used for improving quality of egg shells and preparation method of compound preparation |
Non-Patent Citations (4)
| Title |
|---|
| 乔宏兴等: "黄芪－枯草芽孢杆菌复合发酵制剂对肉鸡生产性能及免疫功能的影响", 《中国兽医学报》 * |
| 武书庚等: "酵母培养物对产蛋鸡生产性能和蛋品质的影响", 《动物营养学报》 * |
| 赵晓静等: "酵母多糖的生理功能及其在鸡生产中的应用", 《饲料博览》 * |
| 高明燕等: "微生态制剂对蛋鸡生产性能及蛋品质的影响", 《黑龙江畜牧兽医》 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106191044A (en) * | 2016-08-05 | 2016-12-07 | 福建农林大学 | A kind of gene engineering method improving lactein plnK yield |
| CN106343262A (en) * | 2016-08-30 | 2017-01-25 | 武汉华扬动物药业有限责任公司 | Method for immune enhancing agent for raising procambarus clarkii and the preparing method thereof and application |
| CN106994157A (en) * | 2017-03-24 | 2017-08-01 | 哈尔滨中科生物工程有限公司 | A kind of herb fermenting preparation, its preparation method and application for improving performance in layers |
| CN107467404A (en) * | 2017-10-23 | 2017-12-15 | 潍坊华光数码设备有限公司 | A kind of feed addictive for laying hen health care and preparation method thereof |
| CN108576479A (en) * | 2018-05-17 | 2018-09-28 | 杨凌职业技术学院 | A kind of feed addictive of layer chicken and preparation method thereof |
| CN110338141A (en) * | 2019-07-17 | 2019-10-18 | 湖北华大瑞尔科技有限公司 | A kind of application of the whole process nonreactive cultural technique scheme in breeding layer chicken |
| CN110463856A (en) * | 2019-09-05 | 2019-11-19 | 广东驱动力生物科技股份有限公司 | A kind of feed addictive improving Layer Production Performance |
| CN113080335A (en) * | 2021-05-18 | 2021-07-09 | 郑州赛科药业科技有限公司 | Fermented traditional Chinese medicine additive for improving egg poultry production performance and preparation method thereof |
| CN114617202A (en) * | 2022-03-29 | 2022-06-14 | 江苏三仪生物工程有限公司 | Compound microecological preparation for improving disease resistance and production performance of ducks as well as preparation method and application of compound microecological preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105767587B (en) | 2019-05-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105767587A (en) | Traditional Chinese medicine microecological preparation for improving laying hen performance and preparation method of traditional Chinese medicine microecological preparation for improving laying hen performance | |
| CN102657292B (en) | Compound feed for 0-21-days-old broiler chicken and preparation method of compound feed | |
| CN106798862B (en) | Traditional Chinese medicine microecological preparation for improving immunity of chicks, preparation method and use method thereof | |
| CN105230568A (en) | Breeding method of high-immunity and high-quality live pigs | |
| CN112568324B (en) | Composite probiotics fermented traditional Chinese medicine feed additive and preparation method and application thereof | |
| CN103156061B (en) | Compound microbial active additive | |
| CN112494577B (en) | Traditional Chinese medicine microecological preparation for treating piglet diarrhea and preparation method thereof | |
| CN105746898A (en) | Chinese herbal medicine feed additive with Folium Callicarpae Nudiflorae and preparation method and application thereof | |
| CN105767543A (en) | Stomach-strengthening and digestion-promoting traditional Chinese medicine micro-ecological preparation for piglet and preparation method thereof | |
| CN108308450A (en) | A kind of feed addictive and preparation method thereof of broiler chicken prophyiaxis and promoting growth | |
| CN108719637A (en) | A kind of growing-finishing pigs Synbiotic feed additive and preparation method and application | |
| CN105876129B (en) | A kind of fermentation of Chinese herbal medicine preparation of alternative antibiotic and its preparation method and application | |
| CN108261515A (en) | It is a kind of to be used to prevent Chinese medicine composition, Chinese medicine microecological preparation of cad pig and its preparation method and application | |
| CN106889329A (en) | One kind is for fattening growth promotion composite biological agent and preparation method thereof | |
| CN113907191A (en) | Traditional Chinese medicine biological fermentation feed, preparation method and application thereof | |
| CN109589361A (en) | A kind of Chinese medicine composition for improving sow fertility rate, Chinese materia medica preparation and preparation method thereof | |
| CN105395674B (en) | A kind of Traditional Chinese medicine probiotic compound formulation and preparation method thereof for preventing and treating fowl gland ventriculitis | |
| CN106135748A (en) | A kind of fowl Chinese herbal medicine microorganism composite feed additive | |
| CN109221697A (en) | Weaned piglets probiotic feed and preparation method thereof | |
| CN113080335A (en) | Fermented traditional Chinese medicine additive for improving egg poultry production performance and preparation method thereof | |
| CN114176170A (en) | Functional feed additive and preparation method and application thereof | |
| CN110521786A (en) | Probiotics fermention yin-nourishing function of relaxing bowel food and its preparation | |
| CN104489261A (en) | Herbal biologic feed additive and preparation method thereof | |
| CN108029878A (en) | A kind of feed addictive and its production method for preventing hog cholera | |
| CN105231017A (en) | Composition promoting growing and fattening of livestock and poultry and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190510 Termination date: 20210429 |