CN105749121A - Folium-artemisiae-argyi-containing traditional Chinese medicine preparation for treating habitual abortion and preparation method thereof - Google Patents
Folium-artemisiae-argyi-containing traditional Chinese medicine preparation for treating habitual abortion and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine and particularly relates to a folium-artemisiae-argyi-containing traditional Chinese medicine preparation for treating habitual abortion and a preparation method thereof.The traditional Chinese medicine preparation comprises folium artemisiae argyi, corn stigma, ramie roots, caulis bambusae in taeniam, radix scutellariae, rhizoma dioscoreae, Chinese wolfberry fruits, radix angelica sinensis, cortex lycii radicis, fructus amomi, fructus aurantii and liquorice roots.The traditional Chinese medicine preparation has the functions of tonifying qi, nourishing blood, tonifying the kidney and preventing miscarriage and further has the curative effects of warming the kidney, tonifying the spleen and soothing and regulating qi-blood, when the traditional Chinese medicine preparation is used for treating habitual abortion, effectiveness is achieved fast, the curative effect is good, toxic and side effects are small, after the traditional Chinese medicine preparation is developed into a finished preparation which is convenient to take, general applicability is good, the curative effect is still remarkable, the production process is simple, and the preparation is easy to apply and popularize.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of habitual abortion containing Folium Artemisiae Argyi and preparation method thereof.
Background technology
All gestation was less than 20 weeks, and fetal weight is termination person less than 500 grams, claimed miscarriage.Habitual abortion refers to and recurs more than 3 times persons.The clinical manifestation of habitual abortion is identical with general miscarriage, is also experience threatened abortion, inevitable abortion, incomplete or artificial abortion several stage.It is hemorrhage a little that early stage can behave as vagina, or has the hidden pain of slight lower abdomen, and the bleeding time can last for days or several weeks, and blood volume is less.Once vaginal hemorrhage is increased, abdomen pain increases the weight of, and checks the existing expansion of cervix uteri mouth, during even visible foetal sac blocking eck, miscarries inevitable.
According to the time that habitual abortion occurs, miscarriage can be divided into early stage habitual abortion and late abortion.Early stage habitual abortion means that miscarriage occurred before pregnant 12 weeks, and general many and inherited genetic factors, female endocrine disturbance and immunology factor etc. are relevant；Late period, habitual abortion referred to that miscarriage occurs after pregnant 12 weeks more, many with uterine malformation, cervical dysplasias is bad, blood group incompatibility and mother suffer from the disease etc., and factor is relevant.
At present, due to western medicine habitual abortion poor effect, and easily recurring, and long-term taking Western medicine has more side effect, therefore, be there is very big demand by people in the Chinese medicine effectively treating habitual abortion.The traditional Chinese medical science think recurrent abortion be " vim and vigour are not enough, thus can not fetus nourishing institute so that tire number is fallen ".Deficiency of kidney-QI includes two aspects, and one is the vital essence of father and mother, if deficiency, though negative and positive can in conjunction with shaping, but liability to abortion, or have deformity, cause miscarriage eventually, even frequency falls；Two is that parent is weak, deficiency of kidney-QI.Weakness of the spleen and stomach mainly results in the deficiency of QI and blood, and the deficiency of vital energy can not carry tire, blood deficiency can not fetus nourishing, so miscarriage.Spleen kidney is double; two to be lost, and vim and vigour are not enough, are the Etiologicals of habitual abortion.Therefore, Chinese traditional treatment habitual abortion focuses on dialectical.Due to habitual abortion many because of deficient qi and blood, suffer from a deficiency of the kidney, heat in blood and wound, cause that endocrine is not enough, the not good miscarriage of qi-blood circulating.So in treatment must with QI invigorating, reinforce the kidney, nourish blood, heat clearing away, the therapy prescriptions such as invigorate blood circulation.In the traditional Chinese medical science, this disease has void to have reality.Deficiency syndrome be suffer from a deficiency of the kidney, deficient qi and blood, it is impossible to supplement nutrition in embryo；Excess syndrome is caused by the cause of disease such as heat in blood, blood stasis damage fetus.According to theory of Chinese medical science, deficiency syndrome should the kidney invigorating, benefiting QI and nourishing blood；Excess syndrome should nourishing YIN to lower pathogenic fire, blood stasis dispelling.
nullChina applies for a patent 201310662360.3 and discloses a kind of medicine treating habitual abortion，What this medicine included following weight portion prepares raw material: Fructus Crataegi 25-35 gram，Radix Paeoniae Alba 25-35 gram，Cortex Eucommiae 25-35 gram，Rhizoma Cibotii 15-25 gram，Rhizoma Chuanxiong 5-15 gram，Cornu Cervi Degelatinatum 5-15 gram，Rhizoma Cyperi 15-25 gram，Herba Agrimoniae 5-15 gram，5-15 gram of Auricularia，15-25 gram of Radix Rubiae，Semen juglandis 5-15 gram，Herba Leonuri 5-15 gram，Herba Cistanches 15-25 gram，Fructus Amomi 5-15 gram，Radix Dipsaci 5-15 gram，Radix Morindae Officinalis 10-20 gram，Radix Scutellariae 10-20 gram，Poria cum Radix Pini 10-20 gram，10-20 gram of Fructus Jujubae，Herba Epimedii 10-20 gram，Fructus Rubi 10-20 gram，Rhizoma Cimicifugae 15-25 gram，Fructus Evodiae 5-15 gram，5-15 gram of Poria，Terra Flava Usta 10-20 gram，Rhizoma Atractylodis Macrocephalae 10-20 gram，Cortex Ailanthi 10-20 gram，Radix Ophiopogonis 10-20 gram，Radix Bupleuri 10-20 gram，Rhizoma Curculiginis 10-20 gram，Endoconcha Sepiae 25-35 gram，Fructus Alpiniae Oxyphyllae 25-35 gram，Arillus Longan 25-35 gram，Radix Isatidis 25-35 gram and Caulis Perillae 25-35 gram.It is supporing yang that this invention medicine has qi-restoratives, during circulation of qi promoting is adjusted, and the function that tonifying liver is antiabortive, but its medication and preparation method are complicated, and in warming the kidney and strengthening the spleen and thin QI and blood regulating, specific aim is not strong, therefore still need to invent more efficiently medicine further.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art, it is provided that the Chinese medicine preparation of a kind for the treatment of habitual abortion containing Folium Artemisiae Argyi, this Chinese medicine preparation not only has benefiting QI and nourishing blood, kidney tonifying and miscarriage prevention, also there is warming the kidney and strengthening the spleen and the effect of thin QI and blood regulating, be used for treating habitual abortion instant effect, good effect, toxic and side effects is little, and after developing into the finished product preparation conveniently taken, it is common to the suitability is good, curative effect is still notable, production technology is simple, it is easy to popularization and application.
What Chinese medicine preparation of the present invention included following weight portion prepares raw material: Folium Artemisiae Argyi 18-25 part, Stigma Maydis 17-22 part, Radix Boehmeriae 15-19 part, Caulis Bambusae In Taenia 13-17 part, Radix Scutellariae 11-16 part, Rhizoma Dioscoreae 13-19 part, Fructus Lycii 9-16 part, Radix Angelicae Sinensis 8-13 part, Cortex Lycii 6-11 part, Fructus Amomi 5-11 part, Fructus Aurantii 9-14 part and Radix Glycyrrhizae 6-13 part.
Further, what described Chinese medicine preparation included following weight portion prepares raw material: Folium Artemisiae Argyi 18 parts, Stigma Maydis 17 parts, Radix Boehmeriae 15 parts, Caulis Bambusae In Taenia 13 parts, Radix Scutellariae 11 parts, Rhizoma Dioscoreae 13 parts, Fructus Lycii 9 parts, Radix Angelicae Sinensis 8 parts, Cortex Lycii 6 parts, Fructus Amomi 5 parts, Fructus Aurantii 9 parts and 6 parts of Radix Glycyrrhizae.
Further, what described Chinese medicine preparation included following weight portion prepares raw material: Folium Artemisiae Argyi 25 parts, Stigma Maydis 22 parts, Radix Boehmeriae 19 parts, Caulis Bambusae In Taenia 17 parts, Radix Scutellariae 16 parts, Rhizoma Dioscoreae 19 parts, Fructus Lycii 16 parts, Radix Angelicae Sinensis 13 parts, Cortex Lycii 11 parts, Fructus Amomi 11 parts, Fructus Aurantii 14 parts and 13 parts of Radix Glycyrrhizae.
Further, what described Chinese medicine preparation included following weight portion prepares raw material: Folium Artemisiae Argyi 20 parts, Stigma Maydis 19 parts, Radix Boehmeriae 17 parts, Caulis Bambusae In Taenia 15 parts, Radix Scutellariae 14 parts, Rhizoma Dioscoreae 15 parts, Fructus Lycii 13 parts, Radix Angelicae Sinensis 10 parts, Cortex Lycii 9 parts, Fructus Amomi 8 parts, Fructus Aurantii 10 parts and 9 parts of Radix Glycyrrhizae.
Correspondingly, the preparation method that the present invention also provides for described Chinese medicine preparation, comprise the following steps: take the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, adding volumetric concentration according to 5～8 times of coarse powder gross weight is the alcoholic solution of 60%～90%, reflux, extract, 2～3 times, and return time is 2～5h, filter, merging filtrate, filtrate recycling ethanol, concentrating under reduced pressure, dry, it is ground into fine powder, crosses 80～100 mesh sieves, obtain Chinese medicine preparation crude drug fine powder of the present invention.
Further, in raw material of Chinese medicine medicine fine powder, add suitable adjuvant, make dosage form needed for clinic with modern Chinese medicine preparation common process, such as capsule, tablet, powder, granule, oral liquid or pill.
The source of component, nature and flavor used by Chinese medicine preparation of the present invention, return through and effect:
Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort；Acrid in the mouth, hardship, warm in nature；Return liver,spleen,kidney warp；Dispersing cold for relieving pain, warming the meridian for stopping bleeding.
Stigma Maydis: this product is style and the fresh idea of grass family Zea plant Zea mays；Sweet in the mouth, light, property is put down；Return bladder, liver, gallbladder meridian；Inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting.
Radix Boehmeriae: this product is the root for contrayerva Boehmeria；Sweet in the mouth, cold in nature；Clearing away heat and promoting diuresis, antiabortive hemostasis, removing toxic substances.
Caulis Bambusae In Taenia: this product is the dry intermediate layer of the stem stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle；Sweet in the mouth, cold nature；Attach to the lung and stomach meridians；Removing heat-phlegm, relieves restlessness and prevents vomiting.
Radix Scutellariae: this product is the dry root of labiate Radix Scutellariae；Bitter in the mouth, cold in nature；Return lung, gallbladder, spleen, large intestine, small intestine meridian；Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.
Rhizoma Dioscoreae: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae；Sweet in the mouth, property is put down；Return spleen, lung, kidney channel；Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.
Fructus Lycii: this product is the dry mature fruit of plant of Solanaceae lycium barbarum；Sweet in the mouth, property is put down；Return liver, kidney channel；Nourishing the liver and kidney, replenishing vital essence to improve eyesight.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica；Sweet in the mouth, pungent, warm in nature；Return liver, the heart, spleen channel；Replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Cortex Lycii: this product is the dry root bark of matrimony vine of solanaceae plant or lycium barbarum；Sweet in the mouth, cold in nature；Return lung, liver, kidney channel；Removing heat from blood is except steaming, lung heat clearing pathogenic fire reducing.
Fructus Amomi: this product is the dry mature fruit of zingiberaceous plant Fructus Amomi, green shell sand or SEMEN AMOMI LONGILIGULA；Acrid in the mouth, warm in nature；Return spleen, stomach, kidney channel；Removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.
Fructus Aurantii: this product is the dry immature fruit of rutaceae Citrus aurantium Linn. and variety thereof；Bitter in the mouth, pungent, sour, warm in nature；Return spleen, stomach warp；Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.；Sweet in the mouth, property is put down；GUIXIN, lung, spleen, stomach warp；Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.The compatibility analysis of Chinese medicine preparation prescription of the present invention:
The Chinese medicine preparation prescription of the present invention foundation traditional Chinese medical science dialectical cognition to treatment habitual abortion, it then follows the compatibility theory of Chinese medicine, in order to make the preparation facilitating easy-to-use and stable curative effect, what enhance medical material makes consumption.This prescription is with Folium Artemisiae Argyi, Radix Boehmeriae and Rhizoma Dioscoreae for monarch drug, and warming the kidney and strengthening the spleen, thin QI and blood regulating and tonifying liver are antiabortive；With Stigma Maydis, Caulis Bambusae In Taenia, Radix Scutellariae and Fructus Lycii for ministerial drug, qi-restoratives is supporing yang, circulation of qi promoting adjust in；With Radix Angelicae Sinensis, Cortex Lycii, Fructus Amomi and Fructus Aurantii for adjuvant drug, menstruction regulating and pain relieving, regulate the flow of vital energy antiabortive；With Radix Glycyrrhizae for making medicine, the coordinating the actions of various ingredients in a prescription property of medicine, all medicines coordinate, and complement each other, synergism, have very significant curative effect in treatment habitual abortion.
Compared with prior art, the present invention has following technical advantage:
(1) Chinese medicine preparation of the present invention not only has benefiting QI and nourishing blood, kidney tonifying and miscarriage prevention, also there is warming the kidney and strengthening the spleen and the curative effect of thin QI and blood regulating, be used for treating habitual abortion instant effect, good effect, toxic and side effects is little, and after developing into the finished product preparation conveniently taken, it is common to the suitability is good, curative effect is still notable, production technology is simple, it is easy to popularization and application.
(2) compared with the chemotherapeutic agent of Current therapeutic habitual abortion, Chinese medicine preparation of the present invention is that natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and Chinese medicine preparation effect of the present invention is comprehensive, and medication effect is more preferably.
(3) cure rate of Chinese medicine preparation of the present invention is 62.5%, total effective rate is 95.0%, total effective rate apparently higher than comparison medicine 55.0%, clinical trial results proves that Chinese medicine preparation of the present invention treatment habitual abortion effect is notable, technical advantage is obvious, therefore can as the drug use of clinical treatment habitual abortion, clinical generalization value is high.
Detailed description of the invention
The present invention is further described below by way of specific embodiment, the present invention is not limited only to following example, within the scope of the invention or without departing from present disclosure, spirit and scope, change, combination or the replacement that the present invention is carried out, will be apparent to the person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
What the embodiment of the present invention 1 Chinese medicine preparation included following parts by weight prepares raw material: Folium Artemisiae Argyi 18 parts, Stigma Maydis 17 parts, Radix Boehmeriae 15 parts, Caulis Bambusae In Taenia 13 parts, Radix Scutellariae 11 parts, Rhizoma Dioscoreae 13 parts, Fructus Lycii 9 parts, Radix Angelicae Sinensis 8 parts, Cortex Lycii 6 parts, Fructus Amomi 5 parts, Fructus Aurantii 9 parts and 6 parts of Radix Glycyrrhizae.
Preparation method: take the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, adding volumetric concentration according to 6 times of coarse powder gross weight is the alcoholic solution of 70%, reflux, extract, 3 times, return time is 3h, filters, merging filtrate, filtrate recycling ethanol, concentrating under reduced pressure, dry, it is ground into fine powder, crosses 80 mesh sieves, obtain Chinese medicine preparation crude drug fine powder of the present invention, add suitable adjuvant, utilizing modern general Chinese medicine preparation technology, gained Chinese medicine preparation is made capsule, amounting to crude drug content is 1.08g crude drug/capsules.
Embodiment 2
What the embodiment of the present invention 2 Chinese medicine preparation included following parts by weight prepares raw material: Folium Artemisiae Argyi 25 parts, Stigma Maydis 22 parts, Radix Boehmeriae 19 parts, Caulis Bambusae In Taenia 17 parts, Radix Scutellariae 16 parts, Rhizoma Dioscoreae 19 parts, Fructus Lycii 16 parts, Radix Angelicae Sinensis 13 parts, Cortex Lycii 11 parts, Fructus Amomi 11 parts, Fructus Aurantii 14 parts and 13 parts of Radix Glycyrrhizae.
Preparation method: take the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, adding volumetric concentration according to 8 times of coarse powder gross weight is the alcoholic solution of 80%, reflux, extract, 3 times, return time is 3h, filters, merging filtrate, filtrate recycling ethanol, concentrating under reduced pressure, dry, it is ground into fine powder, crosses 80 mesh sieves, obtain Chinese medicine preparation crude drug fine powder of the present invention, add suitable adjuvant, utilizing modern general Chinese medicine preparation technology, gained Chinese medicine preparation is made capsule, amounting to crude drug content is 1.08g crude drug/capsules.
Embodiment 3
What the embodiment of the present invention 3 Chinese medicine preparation included following parts by weight prepares raw material: Folium Artemisiae Argyi 20 parts, Stigma Maydis 19 parts, Radix Boehmeriae 17 parts, Caulis Bambusae In Taenia 15 parts, Radix Scutellariae 14 parts, Rhizoma Dioscoreae 15 parts, Fructus Lycii 13 parts, Radix Angelicae Sinensis 10 parts, Cortex Lycii 9 parts, Fructus Amomi 8 parts, Fructus Aurantii 10 parts and 9 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 2.
Embodiment 4
What the embodiment of the present invention 4 Chinese medicine preparation included following parts by weight prepares raw material: Folium Artemisiae Argyi 22 parts, Stigma Maydis 19 parts, Radix Boehmeriae 17 parts, Caulis Bambusae In Taenia 15 parts, Radix Scutellariae 13 parts, Rhizoma Dioscoreae 16 parts, 12 parts of parts of Fructus Lycii, Radix Angelicae Sinensis 10 parts, Cortex Lycii 8 parts, Fructus Amomi 7 parts, Fructus Aurantii 11 parts and 9 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 2.
The beneficial effect of of the present invention Chinese medicine preparation is expanded on further below by way of test example, these tests include animal toxicity test report and the clinical observation material of Chinese medicine preparation of the present invention.
Test example 1, Chinese medicine capsules agent of the present invention animal toxicity test
One, acute toxicity test
1. test medicine: the capsule prepared by the embodiment of the present invention 3, is deployed into the suspension that concentration is 0.8g/ml by content water after the softgel shell that removes photoresist, standby.
2. experimental animal: regular grade NIH mice 10, body weight 19g ± 6g, male and female half and half, female mice is all without pregnant.
3. the solution of mouse stomach Chinese medicine capsules preparation of the present invention, when given low reaches 840.0g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, result of the test shows that this medicine acute toxicity is extremely low, clinical drug safety.
Two, long-term toxicity test for animals
1. experimental animal: regular grade SD rat 40, body weight 230g ± 15g, male and female half and half, female rats, all without pregnant, is divided into 4 groups, often group 10.
2. trial drug and dosage regimen:
The embodiment of the present invention 3 gained Chinese medicine capsules water is deployed into the suspension that concentration is 0.8g/ml, 0.6g/ml and 0.4g/ml, standby.Take 3 groups of rats, it is labeled as high dose group (3.2g/kg), middle dosage group (2.4g/kg) and low dose group (1.6g/kg), high dose group concentration is the drug suspension of 0.8g/ml, middle dosage group concentration is the drug suspension of 0.6g/ml, and low dose group concentration is the drug suspension of 0.4g/ml；Remain one group as a control group: gavage isometric(al) normal saline；Continuous gavage 180 days.
3. result of the test:
Observing animal general toxic reaction and the order of severity, place after death checks each position by rule of operation, and carries out hematology, the pathological examination of the main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach；Through long-term feeding, all there is not toxic reaction in 3 groups of rats, physically well develop, macroscopic appearance and main organs no abnormality seen, peripheral hemogram and Serum ALT, BUN compare without all not significant changes such as pathologic change, the pathological replacement heart, liver, spleen, lung, kidney, stomaches with matched group, therefore, thinking through proved by pathology, animal is showed by this Chinese medicine capsules without chronic toxicity.
By two above toxicity test, it was demonstrated that the Chinese medicine capsules that the present invention is prepared by embodiment 3 is safe, has no side effect, it is possible to taken by patient.
Test example 2, Chinese medicine capsules of the present invention clinical effectiveness test
1, subjects data
Experimenter is all from certain maternity & child care center of city, for the female patient suffering from habitual abortion that this hospital accepted for medical treatment in April, 2014 in February, 2013, therefrom select applicable clinical trial and agree to participate in as clinical volunteers the patient 80 for the treatment of, age 23-36 year, all it is diagnosed as habitual abortion by hospital, and prepares pregnancy person.At random all patients being divided into treatment group and matched group, often organize each 40 examples, respectively 30.2 years old and 30.8 years old mean age, two groups of patients, at the physical data no significant difference such as age, the state of an illness, meet packet condition.
2, trial drug
Treatment group: take the Chinese medicine capsules of the present invention of the embodiment of the present invention 3 preparation.
Matched group: take curing capsule of preventing miscarriage (the quasi-word Z20060004 of traditional Chinese medicines, Gansu Huangfu Mi Pharmaceutical Co).
3, test method
The oral Chinese medicine capsules of the present invention obtained by embodiment 4 for the treatment of group, each 2, every day 2 times；Oral curing capsule (the quasi-word Z20060004 of traditional Chinese medicines that prevents miscarriage of matched group, Gansu Huangfu Mi Pharmaceutical Co), each 3, every day 3 times, within one month, it is a course for the treatment of, 3 courses for the treatment of of treatment continuously, records the health after patient takes medicine, unpregnancy person records official holiday situation, and in therapeutic process, the person of becoming pregnant records patient's pregnancy period response situation, anemia of pregnant woman's associated hormone inspection.All patients are paid a return visit in treatment after terminating 1 year, add up motherhood situation.
4, test evaluation standard
1. cure: patient's habitual abortion related symptoms is wholly absent, and spends the habitual abortion phase smoothly, and gives birth to healthy babies.
2. effective: habitual abortion related symptoms partial disappearance, health takes a turn for the better, but still needs to further treatment.
3. invalid: habitual abortion related symptoms does not have any improvement, even more serious.
5, result of the test statistical analysis
1. physical attributes record: untoward reaction symptom all do not occur in all experimenters, and medication person's health all take a favorable turn, bleeding disappears, lower abdomen pendant pain takes a turn for the better, middle gas foot, and gather colour is paid a return visit display, had the patient of more than half to give birth to healthy baby.
2. result of the test statistical analysis: after the test of all cases, result is carried out statistical analysis calculating, as shown in table 1:
Table 1: the observation of curative effect taken Chinese medicine preparation of the present invention with take routine medication habitual abortion
6, conclusion (of pressure testing)
For this disease of habitual abortion, current doctor trained in Western medicine does not have the treatment of good method, and many employing hormones are prevented miscarriage, and often side effect is big, poor effect, and allows patient body make the matter worse sometimes, and the state of an illness is difficult to control to more.The cure rate of Chinese medicine preparation of the present invention is 62.5%, total effective rate is 95.0%, total effective rate apparently higher than comparison medicine 55.0%, clinical trial results proves that Chinese medicine preparation of the present invention treatment habitual abortion effect is notable, technical advantage is obvious, therefore can as the drug use of clinical treatment habitual abortion, clinical generalization value is high.
Claims (6)
1. the Chinese medicine preparation of the treatment habitual abortion containing Folium Artemisiae Argyi, it is characterized in that, what described Chinese medicine preparation included following weight portion prepares raw material: Folium Artemisiae Argyi 18-25 part, Stigma Maydis 17-22 part, Radix Boehmeriae 15-19 part, Caulis Bambusae In Taenia 13-17 part, Radix Scutellariae 11-16 part, Rhizoma Dioscoreae 13-19 part, Fructus Lycii 9-16 part, Radix Angelicae Sinensis 8-13 part, Cortex Lycii 6-11 part, Fructus Amomi 5-11 part, Fructus Aurantii 9-14 part and Radix Glycyrrhizae 6-13 part.
2. the Chinese medicine preparation of the treatment habitual abortion containing Folium Artemisiae Argyi as claimed in claim 1, it is characterized in that, what described Chinese medicine preparation included following weight portion prepares raw material: Folium Artemisiae Argyi 18 parts, Stigma Maydis 17 parts, Radix Boehmeriae 15 parts, Caulis Bambusae In Taenia 13 parts, Radix Scutellariae 11 parts, Rhizoma Dioscoreae 13 parts, Fructus Lycii 9 parts, Radix Angelicae Sinensis 8 parts, Cortex Lycii 6 parts, Fructus Amomi 5 parts, Fructus Aurantii 9 parts and 6 parts of Radix Glycyrrhizae.
3. the Chinese medicine preparation of the treatment habitual abortion containing Folium Artemisiae Argyi as claimed in claim 1, it is characterized in that, what described Chinese medicine preparation included following weight portion prepares raw material: Folium Artemisiae Argyi 25 parts, Stigma Maydis 22 parts, Radix Boehmeriae 19 parts, Caulis Bambusae In Taenia 17 parts, Radix Scutellariae 16 parts, Rhizoma Dioscoreae 19 parts, Fructus Lycii 16 parts, Radix Angelicae Sinensis 13 parts, Cortex Lycii 11 parts, Fructus Amomi 11 parts, Fructus Aurantii 14 parts and 13 parts of Radix Glycyrrhizae.
4. the Chinese medicine preparation of the treatment habitual abortion containing Folium Artemisiae Argyi as claimed in claim 1, it is characterized in that, what described Chinese medicine preparation included following weight portion prepares raw material: Folium Artemisiae Argyi 20 parts, Stigma Maydis 19 parts, Radix Boehmeriae 17 parts, Caulis Bambusae In Taenia 15 parts, Radix Scutellariae 14 parts, Rhizoma Dioscoreae 15 parts, Fructus Lycii 13 parts, Radix Angelicae Sinensis 10 parts, Cortex Lycii 9 parts, Fructus Amomi 8 parts, Fructus Aurantii 10 parts and 9 parts of Radix Glycyrrhizae.
5. the Chinese medicine preparation of the treatment habitual abortion containing Folium Artemisiae Argyi as claimed in claim 1, it is characterised in that described Chinese medicine preparation is made into capsule, tablet, powder, granule, oral liquid or pill.
6. the preparation method of the Chinese medicine preparation of the treatment habitual abortion containing Folium Artemisiae Argyi as described in as arbitrary in claim 1-4, it is characterized in that, the preparation method of described Chinese medicine preparation comprises the following steps: takes the above-mentioned Chinese crude drug of recipe quantity and is broken into coarse powder, adding volumetric concentration according to 5～8 times of coarse powder gross weight is the alcoholic solution of 60%～90%, reflux, extract, 2～3 times, return time is 2～5h, filter, merging filtrate, filtrate recycling ethanol, concentrating under reduced pressure, dry, it is ground into fine powder, crosses 80～100 mesh sieves, obtain Chinese medicine preparation crude drug fine powder of the present invention.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653590A (en) * | 2009-09-14 | 2010-02-24 | 柴瑞强 | Medicine for treating habitual abortion and preparation method thereof |
| CN104510970A (en) * | 2014-12-02 | 2015-04-15 | 广东聚智诚科技有限公司 | Use of traditional Chinese medicine preparation in preparation of drug for treatment of habitual abortion |
| CN105213948A (en) * | 2015-11-10 | 2016-01-06 | 浙江锦天生物科技有限公司 | A kind of Chinese medicine composition and preparation method and its usage for the treatment of habitual abortion |
-
2016
- 2016-03-29 CN CN201610188957.2A patent/CN105749121A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653590A (en) * | 2009-09-14 | 2010-02-24 | 柴瑞强 | Medicine for treating habitual abortion and preparation method thereof |
| CN104510970A (en) * | 2014-12-02 | 2015-04-15 | 广东聚智诚科技有限公司 | Use of traditional Chinese medicine preparation in preparation of drug for treatment of habitual abortion |
| CN105213948A (en) * | 2015-11-10 | 2016-01-06 | 浙江锦天生物科技有限公司 | A kind of Chinese medicine composition and preparation method and its usage for the treatment of habitual abortion |
Non-Patent Citations (1)
| Title |
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| 漆浩: "《健康新概念：保健偏方验方手册》", 28 February 2000 * |
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