CN105748914A - Traditional Chinese medicine composition for assisting in treatment of nausea and vomiting after chemotherapy of gynecologic malignant tumor - Google Patents
Traditional Chinese medicine composition for assisting in treatment of nausea and vomiting after chemotherapy of gynecologic malignant tumor Download PDFInfo
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- CN105748914A CN105748914A CN201610152287.9A CN201610152287A CN105748914A CN 105748914 A CN105748914 A CN 105748914A CN 201610152287 A CN201610152287 A CN 201610152287A CN 105748914 A CN105748914 A CN 105748914A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/616—Echinodermata, e.g. starfish, sea cucumbers or sea urchins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
Abstract
The invention discloses a traditional Chinese medicine composition for assisting in treatment of nausea and vomiting after chemotherapy of gynecologic malignant tumor. The traditional Chinese medicine composition is prepared from raw materials as follows: beechey fig roots, Yunnan starwort roots, rhizomes of whorledleaf solomonseal, scurrula parasitica, herbs of hairystalk loosestrife, comphortree roots, Notholirion bulbuliferum, viscera of sea cucumber and Asterias amurensis. The provided traditional Chinese medicine composition for assisting in treatment of nausea and vomiting after chemotherapy of gynecologic malignant tumor makes up the defects of western medicines for treating nausea and vomiting after chemotherapy of gynecologic malignant tumor, has definite curative efficacy, particularly has a better treatment effect on tardive vomiting, is convenient to take, has no side effects and is low in price. With the adoption of the provided traditional Chinese medicine composition for assisting in treatment of nausea and vomiting after chemotherapy of gynecologic malignant tumor, a water decoction can treat 40 cases of patients, the total efficiency of a treatment group is 92.50%, the total efficiency of a control group is 67.50%, and the total efficiency of the treatment group is remarkably superior to that of the control group (P is smaller than 0.05).
Description
Technical field
The present invention relates to Chinese medicine sciemtifec and technical sphere, particularly to the Chinese medicine composition of nausea and vomiting after a kind of auxiliary treatment gynecologic malignant tumor chemotherapy.
Background technology
Chemotherapy is the treatment means that gynecologic malignant tumor is important, and nausea and vomiting is untoward reaction the most common in chemotherapy, and wherein the scheme containing platinum-based chemotherapy causes the rate of vomitting up to more than 90%.Chemotherapeutics not only directly stimulating gastrointestinal road cause nausea vomiting, it is also possible to act on oblongata vomiting center and cause vomiting.Owing to misery is heavier, some patients refusal accepts chemotherapy and therapy discontinued, thus control during chemotherapy nausea and vomiting be doctor must faced by a difficult problem.Conventional 5-HT clinically3Receptor blocking agent (such as ondansetron) suppresses the nausea and vomiting that chemotherapeutics causes, and antiemetic effect is more satisfactory, but also has unsatisfactory part, and as safety is troubling, price is costly, invalid etc. to delayed emesis.Treatment by Chinese herbs mechanism plays a role from too many levels, multiple location, it is shown that significantly multi-target effect, treats this disease and has unique advantage.Research and development can make up the Chinese medicine composition of nausea and vomiting after the auxiliary treatment gynecologic malignant tumor chemotherapy that Western medicine is not enough, has important clinical significance.The present inventor inquires into the traditional Chinese medical science pathogeny of nausea and vomiting after gynecologic malignant tumor chemotherapy, sums up years'experiences and develops the Chinese medicine composition of nausea and vomiting, satisfactory effect after a kind of auxiliary treatment gynecologic malignant tumor chemotherapy.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency existing in prior art, namely the Chinese medicine composition of nausea and vomiting after a kind of auxiliary treatment gynecologic malignant tumor chemotherapy is provided.
In order to realize foregoing invention purpose, the invention provides techniques below scheme: the Chinese medicine composition of nausea and vomiting after a kind of auxiliary treatment gynecologic malignant tumor chemotherapy, be made up of the crude drug of following mass ratio: Radix Fici beecheyanae 30～50 parts, Radix Stellariae Yunnanensis 15～25 parts, Rhizoma Polygonati Verticillati 6～10 parts, Ramulus Scurmlae Parasificae 20～40 parts, Herba lysimachiae capillipedis 9～15 parts, Radix Cinnamomi Camphorae 6～10 parts, Bullus Notholirionis Bulbuliferi 2～4 parts, 8～12 parts of Stichopus japonicus internal organs, starfish 9～15 parts.
The pharmacological action of raw material of Chinese medicine medicine of the present invention is as follows:
Radix Fici beecheyanae: sweet, pungent, warm.Invigorating the spleen and benefiting QI, promoting blood circulation to remove obstruction in the collateral, expelling wind and removing dampness.Curing mainly overstrain weak, lack of appetite, breast is few, insufficiency of the spleen leucorrhea, proctoptosis, menoxenia, wind syndrome of head pain, traumatic injury, rheumatic arthritis.
Radix Stellariae Yunnanensis: sweet, flat.Strengthening spleen and nourishing blood, invigorating the liver and kidney, detumescence.Cure mainly anemia, dizzy nervous, tinnitus hectic fever, the soreness of waist, seminal emission, menoxenia, leukorrhagia, fracture, mastitis.
Rhizoma Polygonati Verticillati: hardship sweet, micro-, cool.Spleen reinforcing lung moistening, suppressing the hyperactive liver, removing toxicity for eliminating carbuncles.Cure mainly weakness of the spleen and stomach, xeropulmonary cough, dizziness, headache, sore, carbuncle and painful swelling.
Ramulus Scurmlae Parasificae: pungent, bitter is flat.Wind-damp dispelling, bone and muscle strengthening, promoting blood circulation and detoxication.Cure mainly rheumatic arthralgia, soreness of the waist and knees, stomachache, hypogalactia, traumatic injury, sore swollen toxin.
Herba lysimachiae capillipedis: sweet, nontoxic, flat.Dispel the wind, promoting the circulation of QI to relieve pain, regulating menstruation.Cure mainly flu, cough, rheumatic arthralgia, abdominal distention, menoxenia, furuncle, venom.
Radix Cinnamomi Camphorae: pungent, warm, returns liver, spleen channel.Warming middle-JIAO to relieve pain, and in, damp eliminating.Curing mainly gastralgia, cholera is vomited and diarrhoea, rheumatic arthralgia, skin pruritus etc..
Bullus Notholirionis Bulbuliferi: pungent, bitter, tepor.The chest stuffiness relieving promoting the circulation of QI, stomach invigorating, preventing or arresting vomiting, analgesia, cough-relieving.Cure mainly stomachache abdominal distention, uncomfortable in chest, vomit regurgitation, cough due to wind and cold, infantile convulsion.
Stichopus japonicus internal organs: relieving convulsion, stomach function regulating, rash of detoxifying, promoting regeneration of the tissue and arresting bleeding.Cure mainly epilepsy, infantile dyspepsia, gastric and duodenal ulcers, measles, furuncle, wound.
Starfish: flat, salty, returns liver, stomach, kidney channel.Checking hyperfunction of the liver for relieving convulsion, antacid stomach function regulating, heat-clearing and toxic substances removing.Cure mainly epilepsy, acid regurgitation of having a stomachache, diarrhoea, thyromegaly, otitis media.
Chinese medicine thinks the card that gynecologic malignant tumor is weakened body resistance poison Shengs, and the healthy energy of human body, while killing tumor cell, is also had very big injury by chemotherapeutics, especially to spleen and stomach function injury relatively greatly, causes adverse rising of stomach-QI, nausea and vomiting；Simultaneously because painful, heavier to cause patient greatly alarmed.Therefore invigoration spleen qi, stomach function regulating preventing or arresting vomiting, dissolving blood stasis and detoxication, tranquillizing the mind by relieving convulsion are worked as in treatment.The present invention adopts Radix Fici beecheyanae invigorating the spleen and benefiting QI, blood circulation promoting and blood stasis dispelling；Radix Stellariae Yunnanensis, Rhizoma Polygonati Verticillati strengthening spleen and nourishing blood, removing toxicity for eliminating carbuncles；Ramulus Scurmlae Parasificae qi-restoratives, promoting blood circulation and detoxication；Herba lysimachiae capillipedis promoting the circulation of QI to relieve pain；Radix Cinnamomi Camphorae, Bullus Notholirionis Bulbuliferi invigorating the spleen and regulating the stomach, relieving convulsion preventing or arresting vomiting；Stichopus japonicus internal organs, starfish are relieving convulsion, stomach function regulating, removing toxic substances.All medicines share, and hit pathogenesis.
Preferably, after described auxiliary treatment gynecologic malignant tumor chemotherapy, the Chinese medicine composition of nausea and vomiting is made up of the crude drug of following mass ratio:
Radix Fici beecheyanae 40 parts, Radix Stellariae Yunnanensis 20 parts, Rhizoma Polygonati Verticillati 8 parts, Ramulus Scurmlae Parasificae 30 parts, Herba lysimachiae capillipedis 12 parts, Radix Cinnamomi Camphorae 8 parts, Bullus Notholirionis Bulbuliferi 3 parts, 10 parts of Stichopus japonicus internal organs, starfish 12 parts.
After described auxiliary treatment gynecologic malignant tumor chemotherapy, the Chinese medicine composition of nausea and vomiting can adopt existing Chinese medicine preparation technology to prepare into any conventional oral preparations, such as decocting can be adopted to obtain water decoction said components, it is also possible to by other existing Chinese medicine preparation technology, the Chinese medicine preparation of nausea and vomiting after described auxiliary treatment gynecologic malignant tumor chemotherapy to be prepared into honeyed pill, condensed water honeyed pill, the watered pill, granule, capsule, tablet, powder, unguentum, oral liquid.
Compared with prior art, beneficial effects of the present invention
The Chinese medicine composition of nausea and vomiting after auxiliary treatment gynecologic malignant tumor chemotherapy provided by the invention, compensate for the deficiency of nausea and vomiting after western medicine gynecologic malignant tumor chemotherapy, curative effect is certainly, particularly delayed emesis is had good therapeutical effect, and taking convenience, have no side effect, cheap.
The Chinese medicine composition of nausea and vomiting after a kind of auxiliary treatment gynecologic malignant tumor chemotherapy, clinical efficacy is summed up
1 physical data
Choose Radiotherapy for Gynecologic Malignancy patient 80 example, be randomly divided into treatment group and each 40 examples of matched group.Treatment group 40 example, 39.11 ± 4.51 years old age；Cancer types: cervical cancer 20 example, carcinoma of endometrium 7 example, carcinoma of fallopian tube 2 example, sarcoma of uterus 11 example.Matched group 40 example, 38.90 ± 5.13 years old age；Cancer types: cervical cancer 19 example, carcinoma of endometrium 9 example, carcinoma of fallopian tube 2 example, sarcoma of uterus 10 example.Two groups of physical data such as patient age, cancer types, through statistical analysis, no significant difference (P > 0.05), have comparability.
2 Therapeutic Method
30min ondansetron 8mg intravenous injection before matched group chemotherapy, continuously injection 3 days, treatment group is oral Chinese medicine composition water decoction provided by the invention on the basis of matched group:
Radix Fici beecheyanae 40 grams, Radix Stellariae Yunnanensis 20 grams, Rhizoma Polygonati Verticillati 8 grams, Ramulus Scurmlae Parasificae 30 grams, Herba lysimachiae capillipedis 12 grams, Radix Cinnamomi Camphorae 8 grams, Bullus Notholirionis Bulbuliferi 3 grams, 10 grams of Stichopus japonicus internal organs, starfish 12 grams, conventionally Chinese medicine preparation technology makes water decoction, within first 1 day, take in chemotherapy, everyone every day 1 dose, it serve on 5 days.
3 therapeutic outcomes
3.1 criterions of therapeutical effect: reference World Health Organization (WHO) (WHO) standard (Zhou Jichang. practical Internal Medicine-Oncology. Beijing: People's Health Publisher, 2000:22-24.), it is classified as effective often less by nausea and vomiting: without nausea and vomiting in 24 hours；Effective: n or V 2-3 time in 24 hours；Invalid: n or V > 4 times in 24 hours.
3.2 results: effective 25 examples for the treatment of group, effective 12 examples, invalid 3 examples, total effective rate 92.50%；Effective 16 examples of matched group, effective 11 examples, invalid 13 examples, total effective rate 67.50%.Two groups of total effective rates are compared, difference statistically significant (P < 0.05).
4 model cases
Jiang, female, 48 years old, because of cervical cancer row chemotherapy.30min ondansetron 8mg intravenous injection before chemotherapy, continuously injection 3 days, start oral Chinese medicine composition water decoction provided by the invention for first 1 day in chemotherapy simultaneously, every day 1 dose, serve on 5 days.The gastrointestinal reactions such as nausea and vomiting do not occur during Chemotherapy in Patients.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in further detail.But this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to below example, and all technology realized based on present invention belong to the scope of the present invention.
Embodiment 1, the Chinese medicine composition of nausea and vomiting after a kind of auxiliary treatment gynecologic malignant tumor chemotherapy, it is by Radix Fici beecheyanae 50 grams, Radix Stellariae Yunnanensis 25 grams, Rhizoma Polygonati Verticillati 10 grams, Ramulus Scurmlae Parasificae 40 grams, Herba lysimachiae capillipedis 15 grams, Radix Cinnamomi Camphorae 10 grams, Bullus Notholirionis Bulbuliferi 4 grams, 12 grams of Stichopus japonicus internal organs, starfish 15 grams, conventionally Chinese medicine preparation technology makes water decoction, within first 1 day, take in chemotherapy, everyone every day 1 dose, it serve on 5 days.
Embodiment 2, the Chinese medicine composition of nausea and vomiting after a kind of auxiliary treatment gynecologic malignant tumor chemotherapy, it is by Radix Fici beecheyanae 40 grams, Radix Stellariae Yunnanensis 20 grams, Rhizoma Polygonati Verticillati 8 grams, Ramulus Scurmlae Parasificae 30 grams, Herba lysimachiae capillipedis 12 grams, Radix Cinnamomi Camphorae 8 grams, Bullus Notholirionis Bulbuliferi 3 grams, 10 grams of Stichopus japonicus internal organs, starfish 12 grams, conventionally Chinese medicine preparation technology makes water decoction, within first 1 day, take in chemotherapy, everyone every day 1 dose, it serve on 5 days.
Embodiment 3, the Chinese medicine composition of nausea and vomiting after a kind of auxiliary treatment gynecologic malignant tumor chemotherapy, it is by Radix Fici beecheyanae 30 grams, Radix Stellariae Yunnanensis 15 grams, Rhizoma Polygonati Verticillati 6 grams, Ramulus Scurmlae Parasificae 20 grams, Herba lysimachiae capillipedis 9 grams, Radix Cinnamomi Camphorae 6 grams, Bullus Notholirionis Bulbuliferi 2 grams, 8 grams of Stichopus japonicus internal organs, starfish 9 grams, conventionally Chinese medicine preparation technology makes water decoction, within first 1 day, take in chemotherapy, everyone every day 1 dose, it serve on 5 days.
Claims (3)
1. the Chinese medicine composition of nausea and vomiting after an auxiliary treatment gynecologic malignant tumor chemotherapy, it is characterised in that be made up of the crude drug of following mass ratio:
Radix Fici beecheyanae 30～50 parts, Radix Stellariae Yunnanensis 15～25 parts, Rhizoma Polygonati Verticillati 6～10 parts, Ramulus Scurmlae Parasificae 20～40 parts, Herba lysimachiae capillipedis 9～15 parts, Radix Cinnamomi Camphorae 6～10 parts, Bullus Notholirionis Bulbuliferi 2～4 parts, 8～12 parts of Stichopus japonicus internal organs, starfish 9～15 parts.
2. the Chinese medicine composition of nausea and vomiting after auxiliary treatment gynecologic malignant tumor chemotherapy as claimed in claim 1, it is characterised in that be made up of the crude drug of following mass ratio:
Radix Fici beecheyanae 40 parts, Radix Stellariae Yunnanensis 20 parts, Rhizoma Polygonati Verticillati 8 parts, Ramulus Scurmlae Parasificae 30 parts, Herba lysimachiae capillipedis 12 parts, Radix Cinnamomi Camphorae 8 parts, Bullus Notholirionis Bulbuliferi 3 parts, 10 parts of Stichopus japonicus internal organs, starfish 12 parts.
3. the preparation method of the Chinese medicine composition of nausea and vomiting after auxiliary treatment gynecologic malignant tumor chemotherapy as claimed in claim 1, it is characterised in that the Chinese medicinal components of described mass ratio is prepared into water decoction, honeyed pill, condensed water honeyed pill, the watered pill, granule, capsule, tablet, powder, unguentum, oral liquid.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107184926A (en) * | 2017-05-08 | 2017-09-22 | 黄河科技学院 | A kind of Chinese medicine composition of auxiliary treatment gynecologic malignant tumor |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104645302A (en) * | 2015-03-20 | 2015-05-27 | 济南鸿飞生物技术有限公司 | Medicine for alleviating postoperative chemotherapy-induced nausea and vomiting of patient with encephaloma and preparation method |
| CN104740206A (en) * | 2015-03-14 | 2015-07-01 | 武霞 | Traditional Chinese medicine preparation for preventing nausea and vomiting caused by tumor chemotherapy |
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- 2016-03-17 CN CN201610152287.9A patent/CN105748914A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104740206A (en) * | 2015-03-14 | 2015-07-01 | 武霞 | Traditional Chinese medicine preparation for preventing nausea and vomiting caused by tumor chemotherapy |
| CN104645302A (en) * | 2015-03-20 | 2015-05-27 | 济南鸿飞生物技术有限公司 | Medicine for alleviating postoperative chemotherapy-induced nausea and vomiting of patient with encephaloma and preparation method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107184926A (en) * | 2017-05-08 | 2017-09-22 | 黄河科技学院 | A kind of Chinese medicine composition of auxiliary treatment gynecologic malignant tumor |
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