CN105748868A

CN105748868A - Traditional Chinese medicine for treating herpes simplex viral keratitis and preparation method thereof

Info

Publication number: CN105748868A
Application number: CN201610236277.3A
Authority: CN
Inventors: 王鑫磊
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-04-15
Filing date: 2016-04-15
Publication date: 2016-07-13

Abstract

The invention provides traditional Chinese medicine for treating herpes simplex viral keratitis and a preparation method thereof.The traditional Chinese medicine comprises Indian strawberry root, Stachys sieboldi, Cremastra appendiculata, Acanthopanax root, Ternstroemia gymnanthera, asparagus fern, tabasheer, pagoda leaf, Berberis dasystachya, root of Soulie barberry, Botrychium ternatum, Artemisia japonica, short-leaf kyllinga herb, Chinese pearleaf crabapplke herb, Spiraea root, rubus root, Cordyceps cicadae and Herba piperis sarmentosi.The traditional Chinese medicine has the advantages that the traditional Chinese medicine is combined with Western medicine to treat herpes simplex viral keratitis, and is convenient to use, better in treatment effect, free of toxic and side effect and adverse reaction, quick in action, less prone to causing recurrence and simple in preparation process.

Description

A kind of Chinese medicine treating herpes simplex keratitis and preparation method thereof

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine treating herpes simplex keratitis and preparation method thereof.

Background technology

Herpes simplex virus (Herpessimplexvirus, HSV) is that nature is widely present the infective virus infecting the mankind.The Corneal inflammation that herpes simplex infections causes is called herpes simplex keratitis (Herpessimplexkeratitis, HSK).Eye HSV infects and is mainly caused by HSV-1.HSV-1 keratitis is common, serious keratopathy, occupies the first place of keratopathy sickness rate and causes of blindness.It is the complexity oculopathy by viral infection, immunity and inflammatory reaction participation, corneal damage and ocular organizational structure, is also endanger one of serious infectious eye disease now.

The Corneal inflammation that herpes simplex infections causes is called herpes simplex keratitis (Herpessimplexkeratitis, HSK).HSV-1 keratitis is common, serious keratopathy, occupies the first place of keratopathy sickness rate and causes of blindness.Herpes simplex keratitis is common keratopathy the most serious at present, had in recent years and substantially rises and aggravation trend.Due to the extensive use of antibiotic and corticosteroid, its sickness rate is on the rise.The often serious harm visual function because of recurrent exerbation, clinic there is no the medicine of effective Control in recurring, thus becomes a kind of global important causes of blindness.

The traditional Chinese medical science is referred to as " dendritic keratitis ", this finding disease, and black eyeball wind wheel has punctate keratitis, poly-or scattered, and cluster arranges, once punctate keratitis ulceration, merges in flakes, and in tree-shaped image, then the traditional Chinese medical science is also known as " keratomalacia ".Primary disease belongs to wind wheel disease, wind wheel planted agent's liver and gall, therefore the formation of primary disease is correlated with more than liver and gall.All affection due to external wind and heat (wind and cold) poison is evil, and endogenous cause of ill liver fire exuberance, wind-fire pyretic toxicity is fought mutually, above attacks in order；Or taste accumulate long-pending damp and hot, stifling black eyeball；Or the hepatic and renal YIN deficiency, hyperactivity of deficient fire, this all can be caused sick.Liver lung is hot and suffocating, and again by ailment said due to cold or exposure, wind-fire is fanned mutually, above attacks in wind wheel as suffering from, also has in liver dampness-heat in the spleen and stop up, and stifling black eyeball is fallen ill.Common photophobia is shed tears, and pain looks paste, protracted course of disease, and black eyeball leaves cataracta in the future, lifelong depending on sticking with paste.

Summary of the invention

The technical problem to be solved is in that, utilizes the theory of Chinese medical science that China is traditional, it is provided that Chinese medicine for the treatment of herpes simplex keratitis that a kind of therapeutic effect is good and free of toxic effects and preparation method thereof.

In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine treating herpes simplex keratitis, described Chinese medicine includes following raw medicinal material: Radix duchesneae indicae, Rhizoma Humatae Tyermanni, Cremastra appendiculata, Radix Kalopanacis, Ternstroemia gymnanthera, Herba Asparagi Setacei, Concretio silicea Bambusae seu schizostachyi, Japanese pagodatree leaf, Cortex berberidis dasystachyae, little Rhizoma Coptidis thorn, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Herba Artemisiae Japonicae, Herba Kyllingae, Folium Mali Asiaticae, Radix spiraeae japonicae, Radix Rubi, Periostracum cicadae and vacation.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Radix duchesneae indicae 15～30 parts, Rhizoma Humatae Tyermanni 15～25 parts, Cremastra appendiculata 30～40 parts, Radix Kalopanacis 10～25 parts, Ternstroemia gymnanthera 5～15 parts, Herba Asparagi Setacei 25～35 parts, Concretio silicea Bambusae seu schizostachyi 15～25 parts, Japanese pagodatree leaf 10～20 parts, Cortex berberidis dasystachyae 15～30 parts, little Rhizoma Coptidis stings 20～35 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 30～40 parts, Herba Artemisiae Japonicae 15～25 parts, Herba Kyllingae 5～15 parts, Folium Mali Asiaticae 20～30 parts, Radix spiraeae japonicae 5～15 parts, Radix Rubi 20～30 parts, Periostracum cicadae 25～35 parts and vacation 15～25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Radix duchesneae indicae 20～25 parts, Rhizoma Humatae Tyermanni 15～20 parts, Cremastra appendiculata 35～40 parts, Radix Kalopanacis 20～25 parts, Ternstroemia gymnanthera 10～15 parts, Herba Asparagi Setacei 25～30 parts, Concretio silicea Bambusae seu schizostachyi 15～20 parts, Japanese pagodatree leaf 10～15 parts, Cortex berberidis dasystachyae 25～30 parts, little Rhizoma Coptidis stings 20～25 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 30～35 parts, Herba Artemisiae Japonicae 20～25 parts, Herba Kyllingae 10～15 parts, Folium Mali Asiaticae 20～25 parts, Radix spiraeae japonicae 5～10 parts, Radix Rubi 20～25 parts, Periostracum cicadae 25～30 parts and vacation 15～20 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Radix duchesneae indicae 21 parts, Rhizoma Humatae Tyermanni 18 parts, Cremastra appendiculata 36 parts, Radix Kalopanacis 25 parts, Ternstroemia gymnanthera 12 parts, Herba Asparagi Setacei 28 parts, Concretio silicea Bambusae seu schizostachyi 16 parts, Japanese pagodatree leaf 15 parts, Cortex berberidis dasystachyae 26 parts, little Rhizoma Coptidis sting 25 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 32 parts, Herba Artemisiae Japonicae 25 parts, Herba Kyllingae 12 parts, Folium Mali Asiaticae 25 parts, Radix spiraeae japonicae 7 parts, Radix Rubi 25 parts, Periostracum cicadae 26 parts and vacation 19 parts.

When the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:

The first step, Radix duchesneae indicae, Rhizoma Humatae Tyermanni, Cremastra appendiculata, Radix Kalopanacis, Ternstroemia gymnanthera, Herba Asparagi Setacei, Concretio silicea Bambusae seu schizostachyi, Japanese pagodatree leaf, Cortex berberidis dasystachyae and little Rhizoma Coptidis thorn is mixed in proportion, add relative to the alcohol reflux that mixture 3 times～5 times amount determining alcohol is 55%～65% 2 times～4 times, each 2 hours～3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30～1.32, standby；

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils 2～4 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27～1.29；

3rd step, the mastic mixing first step, second step obtained, 55 DEG C～65 DEG C reduced vacuum dry, and get dry extract powder；

4th step, carries out mixing process by described dried cream powder and starch, obtains mastic mixture；Described mastic and the weight ratio of starch are 1: 0.01～0.02；Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained；

5th step, is sequentially carried out described mastic compound particles and Pulvis Talci, magnesium stearate mixing process, tabletting process, Cotton seeds, obtains Chinese medicinal tablet finished product；Described granule, Pulvis Talci, magnesium stearate weight ratio be 100: 1～3: 0.15～0.3.

When the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

The first step, Radix duchesneae indicae, Rhizoma Humatae Tyermanni, Cremastra appendiculata, Radix Kalopanacis, Ternstroemia gymnanthera and Herba Asparagi Setacei are mixed in described ratio, add the water extraction volatile oil relative to 4～6 times of mixture, the volatile oil beta-cyclodextrin inclusion compound that will obtain, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3～6, stirs 75 minutes～90 minutes, temperature 30 DEG C～50 DEG C, obtain volatile oil clathrate compound, standby；It is the clear paste of 1.15～1.17 that aqueous extract is separately concentrated into relative density when 60 DEG C；

Second step, Concretio silicea Bambusae seu schizostachyi, Japanese pagodatree leaf, Cortex berberidis dasystachyae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Herba Artemisiae Japonicae and Herba Kyllingae are mixed in described ratio, add relative to the alcohol reflux that mixture 6～8 times amount determining alcohol is 80%～90% 3～5 times, each 2～3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into relative density when 60 DEG C is the clear paste of 1.20～1.22, standby；

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8～10 times amount water, boil 6～8 hours, filter, and being concentrated into relative density when 65 DEG C is the clear paste of 1.28～1.30；

4th step, mixes the clear paste of the first step, second step, the 3rd step, and 60 DEG C～70 DEG C reduced vacuum dry, and get dry extract powder；

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is sufficiently mixed, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 5～8 weight portion carboxymethyl starch sodium, 10～50 weight starch mix homogeneously, adding 150～200 weight portion determining alcohols is 80%～90% alcohol granulation, dry, granulate, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3～5 weight portion magnesium stearate, are then charged in gelatine capsule.

Beneficial effects of the present invention: the Chinese medicine associating western medicine herpes simplex keratitis of the present invention, easy to use, therapeutic effect is better, has no side effect and untoward reaction, and instant effect not easily recurs, and preparation technology is simple.

Detailed description of the invention

The invention provides a kind of Chinese medicine treating herpes simplex keratitis, Chinese medicine includes following raw medicinal material: Radix duchesneae indicae, Rhizoma Humatae Tyermanni, Cremastra appendiculata, Radix Kalopanacis, Ternstroemia gymnanthera, Herba Asparagi Setacei, Concretio silicea Bambusae seu schizostachyi, Japanese pagodatree leaf, Cortex berberidis dasystachyae, little Rhizoma Coptidis thorn, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Herba Artemisiae Japonicae, Herba Kyllingae, Folium Mali Asiaticae, Radix spiraeae japonicae, Radix Rubi, Periostracum cicadae and vacation.

The pharmacology of various raw medicinal materials is as follows:

Radix duchesneae indicae: [another name] three skin wind root, Serpentis bubble grass roots.[source] medical material Ji Yuan: for the root of rosaceous plant Herba Duchesneae Indicae.[nature and flavor] are bitter, sweet；Cold.[return through] lung；Liver；Stomach warp.[function cures mainly] clearing away heat-fire；Removing toxic substances and promoting subsidence of swelling.Main calentura, water infantile convulsion, conjunctival congestion is red and swollen, mumps, gingival swelling and pain, laryngopharynx swelling and pain, pathopyretic ulcer.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Humatae Tyermanni: [another name] Chinese artichoke, drip dew, Stachys geobombycis C. Y. Wu, Chinese artichoke, soil common house centipede, Chinese artichoke, snail dish, eupolyphage sece steleophaga grass, Radix Talini Paniculati, soil stamen, hair dish, wind is careless, Myrmeleonmicans Mac Lachlan careless, knob, screw dish.[source] comes from supplementary Amplifications of the Compendium of Materia Medica.[source] medical material Ji Yuan: for tuber and the herb of labiate Rhizoma Humatae Tyermanni.Gather and store: spring, autumn gather.Take tuber, clean, dry.[nature and flavor] sweet in the mouth；Property is put down.[return through] returns lung；Liver；Spleen channel.[function cures mainly] induces sweat lung heat clearing；Eliminating damp, detoxifying；Qi-restoratives spleen invigorating.Main anemopyretic cold；Cough due to consumptive disease；Jaundice；Stranguria；Sore swells and ache；Venom.[extracts] " China's book on Chinese herbal medicine "

Cremastra appendiculata: [another name] dragon gulps down pearl, Long Xuguo, Shen Xianguo, fragrant flower fruit, Fructus Fici Beecheyanae.[source] medical material Ji Yuan: for Herb or the fruit of Passifloraceae plant Cremastra appendiculata.[nature and flavor] sweet in the mouth；Acid；Property is put down.[function cures mainly] heat-clearing and toxic substances removing；Clearing away lung-heat to relieve cough.Main cough due to lung-heat；Turbid urine；Ulcerative carbuncle toxic swelling；Traumatic eye keratitis；Lymphadenitis, [each discussion] " Nanning City's medicine will ": Herb: heat clearing away, removing toxic substances, diuretic.Control cough due to lung-heat, edema, nebulousurine.Apply rotten foot ulcerative carbuncle.[extracts] " China's book on Chinese herbal medicine "

Radix Kalopanacis: [another name] thorn root white skin, Ramulus Kalopanacis seu Araliae root bark, nail ebon root, Radix Et Caulis Acanthopanacis Senticosi, Kalopanax septemlobum root.[source] comes from " Traditional Chinese Medicine in Sichuan will ".[source] medical material Ji Yuan: for root or the root bark of Araliaceae Kalopanax septemlobum.Gather and store: excavating more than at the beginning of autumn late summer, cleaning, cut into slices or strip root bark section, using fresh herb or dry.[nature and flavor] bitter in the mouth；Micro-pungent；Property is put down.[function cures mainly] cool the blood dissipate blood stasis；Expelling wind and removing dampness；Removing toxic substances.Main discharging fresh blood stool；Beriberoid pyretic arthralgia；Traumatic injury；Fracture；Wealth body edema；Sore swollen toxin；Scrofula；Hemorrhoid.[each discussion] 1. " conventional glossary of Herbs and Drugs among the people ": control hemorrhoid, heat-clearing and toxic substances removing.2. " Traditional Chinese Medicine in Sichuan will ": dissipating blood, heat clearing away, except rheumatism.Control discharging fresh blood stool, traumatic injury and rheumatic ostalgia.3. " Shaanxi Chinese herbal medicine ": heat clearing away, removing heat from blood, except rheumatism, evacuation of pus granulation promoting.[extracts] " China's book on Chinese herbal medicine "

Ternstroemia gymnanthera: [another name] Fructus seu Flos Ternstroemiae Gymnantherae, weighing lever is red, Mo Hong cuts, Flos Camelliae Japonicae tree, Sanguis sus domestica bavin, QI and blood rattan, big five tastes rattan.[source] Ternstroemia gymnanthera begins to be loaded in " Zhiwu Mingshi Tukao ", meaning: " in raw mountain, Yunnan, the sliding leaf of little tree, such as SHANZHIZI, open five lobes and spend in vain; micro-round and round lack, gather closely together between branch, slightly fragrance, red calyx is like prunus mume (sieb.) sieb.et zucc.; thick lobe such as wax, opens in dog days, the southern regions of the Yunnan Province summer, in four Flos Chimonanthi Praecocis person on sale namely this.".Only meaning is opened five lobes and is spent in vain, with this product flower for faint yellow slightly different.[source] medical material Ji Yuan: for leaf or the Herb of plant of theaceae Ternstroemia gymnanthera.Gather and store: the whole year all can gather, chopping, dry or using fresh herb.[nature and flavor] are bitter；Cool；Slightly poisonous.[function cures mainly] heat-clearing and toxic substances removing；Dissipating blood stasis for subsidence of swelling.Main sore and toxic；Acute mastitis.[extracts] " China's book on Chinese herbal medicine "

Herba Asparagi Setacei: [another name] Peng Lai bamboo, Radix Asparagi Officinalis.[source] comes from " Fujian traditional herbal medicine ".[source] medical material Ji Yuan: for tuber or the Herb of liliaceous plant Herba Asparagi Setacei.Gather and store: prescinding viticula, lifted root autumn, remove earth, with decocting in water or steam to rhagades of the skin, peelling off crust, cutting, dry.Herb all can be adopted the whole year, using fresh herb or dry.[nature and flavor] sweet in the mouth；Micro-hardship；Cold in nature.[function cures mainly] nourishing the lung to arrest cough；Removing heat from blood leads to woods.Main lung-dryness syndrome due to deficiency of YIN；Cough；Spitting of blood；Dribbling urination.[extracts] " China's book on Chinese herbal medicine "

Concretio silicea Bambusae seu schizostachyi: [another name] phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle Huang, ZHUSANQI, XUESANQI, bamboo ginseng, red dumpling, the red dumpling of bamboo, the red plaque of bamboo, light Flos Chrysanthemi, Concretio silicea Bambusae seu schizostachyi, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle, bamboo, bamboo cocoon.[source] comes from Zhejiang.[source] medical material Ji Yuan: for Stroma and the spore of Hypocreaceae Fungus Zhuhuang.[nature and flavor] are lightly seasoned；Pungent；Flat.[return through] lung；Liver Channel.[function cures mainly] preventing phlegm from forming and stopping coughing；Promoting blood circulation by removing wind；Dampness removing.Main cough with copious phlegm；Pertussis；Leukorrhagia；Stomachache；Rheumatic arthralgia；Infantile convulsion；Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Japanese pagodatree leaf: [source] medical material Ji Yuan: for the leaf of leguminous plant Chinese scholartree.[nature and flavor] bitter in the mouth；Property is put down.[return through] liver；Stomach warp.[function cures mainly] purging liver-fire；Removing pathogenic heat from blood and toxic substance from the body；Removing dampness and killing parasites.Main pediatric epilepsy scared；High fever；Hemorrhoidal hamorrhage；Hematuria；Hemorrhoid；Eczema；Scabies；Ulcerative carbuncle furuncle swells.[extracts] " China's book on Chinese herbal medicine "

Cortex berberidis dasystachyae: [another name] yellow three thorns, Cortex Phellodendri, thorn Cortex Phellodendri, mountain Cortex Phellodendri, yellow three peroniums, Ji Gaer, Herba Kyllingae.[source] comes from " Chinese herbal medicine handbook is commonly used in Qinghai ".[source] medical material Ji Yuan: for root and the branch endothelium of the straight fringe Radix Berberidis Amurensis of Berberidaceae plant, cadmium yellow Radix Berberidis Amurensis and kansu barberry bark.Gather and store: root is excavated autumn, going fibrous root and earth, bark fetching, section, dry.When stem sprouted between the 4-5 month, cut and take thicker stem, scrape off rough bark, remove core, extracting yellow cortex and bast zone, dry.[nature and flavor] are bitter；Cold in nature.[return through] lung；Stomach；Large intestine channel.[function cures mainly] clearing away damp-heat；Relieving heat toxin.Main hygropyretic dysentery；Jaundice；Leukorrhagia；Pyretic toxicity carbuncle.[extracts] " China's book on Chinese herbal medicine "

Little Rhizoma Coptidis is stung: [another name] CIHUANQIN, Radix Ilicis Pernyi, Cortex Phellodendri thorn, little Cortex Phellodendri thorn, Ilex pernyi, Herba Kyllingae.[source] comes from " Shaanxi Chinese herbal medicine will ".[source] medical material Ji Yuan: for root and the stem branch of Berberidaceae plant cone flower Radix Berberidis Amurensis.Gather and store: gather in spring, autumn root and stem branch, scraping off rough bark, section, dry.[nature and flavor] bitter in the mouth；Cold in nature.[function cures mainly] heat clearing and damp drying；Eliminating fire and detoxication.Main damp-heat dysentery；Acute catarrhal conjunctivitis swells and ache；Pyretic stranguria, leukorrhagia；Carbuncle sore tumefacting virus；Eczema.[extracts] " China's book on Chinese herbal medicine "

Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw.: [another name] YIDUOYUN, Herba pteridii latiusculi.[source] comes from " Shaanxi Chinese herbal medicine ".[source] medical material Ji Yuan: for root or the herb of Botrychiaceae plant Herba pteridii latiusculi beanstalk.Gather and store: spring excavates, cleaning, dry or using fresh herb.[nature and flavor] are bitter；Puckery；Cool；Sweet；It is slightly cold.[return through] lung；Liver Channel.[function cures mainly] heat-clearing and toxic substances removing；Suppressing the hyperactive liver eliminating stagnation；Expelling wind for relieving convulsion.Main lung abscess；Venom；Conjunctival congestion；Scrofula；Cough；Snake venom；Acute infantile convulsion wind；Rheumatic arthralgia；Traumatic injury.[each discussion] 1. " Shaanxi Chinese herbal medicine ": heat-clearing and toxic substances removing, suppressing the hyperactive liver eliminating stagnation.Control lung abscess, conjunctivitis, impairment caused by overstrain, venom, scrofula.2. Nanchuan " conventional Chinese herbal medicine handbook ": qi-restoratives lung moistening, relieving cough and resolving phlegm.Control cough, weak and celostomia after being ill.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Herba Artemisiae Japonicae: [another name] is flush Artemisia, water hot food, distribute food among the guests, soil Radix Bupleuri, monkey palm grass, stream urine Artemisia, Common Rue Herb, gram head green grass or young crops, oil Chinese mugwort, oil Artemisia, oil are fluffy, milk infantile malnutrition medicine, flower Folium Artemisiae Argyi, Serissa foetida, crow, horse lotus Artemisia, Ma Genchai, goose medical herbs, subdigitate wormwood herb, spend Artemisia in vain, Pedis Ursus grass, chrysanthemum Ye Chaihu, sole Artemisia, Hua Dengcao, spoon leaf end.[source] comes from " Mingyi Bielu ".[source] medical material Ji Yuan: for the herb of feverfew Herba Artemisiae Japonicae.Gather and store: herb of gathering between summer, autumn, drying or using fresh herb.[nature and flavor] bitter in the mouth；Micro-sweet；Cool in nature.[function cures mainly] heat clearing away；Removing heat from blood；Removing toxic substances.Main summer catches a cold；Pulmonary tuberculosis hectic fever；Spitting of blood；Children's's infantile malnutrition with fever；Epistaxis；Have blood in stool；Metrorrhagia；Leukorrhagia；Icterohepatitis；Erysipelas；Venom.[extracts] " China's book on Chinese herbal medicine "

Herba Kyllingae: [another name] myriogyne minuta, valida limaciopsis, three pod grass, Herba Polygalae Telephioidis, cold grass, gold button grass, rub night grass, cross grass, Rhizoma Zingiberis Recens Cordyceps, Radix Cyanotis vagae, Babalus bubalis L. grass, three steps are jumped, cold expelling grass, Rhizoma Zingiberis Recens wheatgrass, cold muscle grass, water Rhizoma Cyperi, Yan Hanzhu, diaphoresis grass, mountain Scolopendra, Rhizoma Cyperi without a head, Clerodendrum thomsonae Balf., three JIACAO, water Rhizoma et radix valerianae, one granular snow, Herba Chlorophyti Laxi, land Fructus Myricae rubrae, three arrow grass, bulb grass, Thunder God grass, Herba seu Fructus Luzulae Multiflorae, three people shoulder pearl, cold and heat head grass, one pearl, nine perfume (or spice), Phyllostachys congesta alms bowl, one pass, Canis familiaris L. public affairs grass, Radix Linderae Chunii, land Hirudo, Rhizoma Sparganii ring, one particle grass, Huang Gutou draws, water Dendrobium nobile Lindl, water and soil is fragrant, steel fist, Lian Gencao, grass is containing pearl.[source] comes from " Zhiwu Mingshi Tukao ".[source] medical material Ji Yuan: for the sedge Herba Kyllingae herb with rhizome.[nature and flavor] acrid in the mouth；Micro-hardship；Sweet；Property is put down.[return through] lung；Liver Channel.[function cures mainly] dispelling wind detoxifies；Clearing away heat-damp and promoting diuresis；Promoting blood circulation and detoxication.Main cold, fever is had a headache；Acute bronchitis；Pertussis；Malaria；Jaundice；Dysentery；Chyluria；Sore swollen toxin；Skin pruritus；Venom；Rheumatic arthritis；Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Folium Mali Asiaticae: [another name] Fructus Mali Asiaticae.[source] medical material Ji Yuan: for the leaf of rosaceous plant premium.[nature and flavor] are pungent；Tepor.[return through] lung meridian [function cures mainly] purging pathogenic fire and improving eyesight, parasite killing detoxifies..Dominant eye bluish eyes is blind, pterygium, children's's scabies.[extracts] " China's book on Chinese herbal medicine "

Radix spiraeae japonicae: [another name] burns point, Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori).[source] medical material Ji Yuan: for the root of rosaceous plant pink blossom Ramulus et Folium Spiraeae Salicifolia, light leaf Ramulus et Folium Spiraeae Salicifolia.[nature and flavor] are bitter, pungent；Cool；Nontoxic.[return through] lung；Liver Channel.[function cures mainly] expelling wind and clearing away heat, improving acuity of vision and removing nebula.Main cough, headache, toothache, cataract.[each discussion] 1. " Guizhou folk medicine ": cough-relieving, analgesia, control nebula improving eyesight.[extracts] " China's book on Chinese herbal medicine "

Radix Rubi: [source] medical material Ji Yuan: for the root of rosaceous plant Fructus Rubi.[nature and flavor] are bitter；Flat.[return through] stomach；Liver Channel.[function cures mainly] wind-expelling pain-stopping, improving acuity of vision and removing nebula, stomach function regulating preventing or arresting vomiting.Cardinal teeth pain, rheumatic arthralgia, corneal nebula, vomiting.[extracts] " China's book on Chinese herbal medicine "

Periostracum cicadae: [another name] worm flower, hat Cicadae, flower.[source] medical material Ji Yuan: for the coremium of Clavicipitaceae fungus Cicadae Isaria bacterium, the Stroma of big Cicadae grass and altogether parasitic polypide.[nature and flavor] are sweet；Cold；Nontoxic.[return through] lung, Liver Channel.[function cures mainly] dispelling wind and heat pathogens；Rash；Relieving spasm by subduing liver-wind；Improving acuity of vision and removing nebula.Main affection due to external wind and heat；Heating；Dizzy；Pharyngalgia；The single board computer rash initial stage；Rash goes out not smooth；Infantile convulsion；Conjunctival congestion and swelling pain；Pterygium；Night cry.[extracts] " China's book on Chinese herbal medicine "

False: [another name] clam, smelly beach wormwood, mountain beach wormwood, Horse hoof beach wormwood.[source] medical material Ji Yuan: for the stem of Piperaceae plant vacation, leaf or herb.[nature and flavor] are bitter；Warm in nature.[return through] heart；Lung；Spleen；Large intestine channel.[function cures mainly] expelling wind and cold；Promoting the circulation of QI to relieve pain；Active；Detumescence.Main air is trembled with fear cough with asthma；Rheumatic arthralgia；Distension and fullness in the abdomen；Dysentery；Puerperal swelling of the feet；Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

When the dosage form of described Chinese medicine is tablet, it comprises the following steps:

When the dosage form of described Chinese medicine is capsule, it comprises the following steps:

Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.

Embodiment 1: tablet prepared by the present invention

Take Radix duchesneae indicae 210g, Rhizoma Humatae Tyermanni 180g, Cremastra appendiculata 360g, Radix Kalopanacis 250g, Ternstroemia gymnanthera 120g, Herba Asparagi Setacei 280g, Concretio silicea Bambusae seu schizostachyi 160g, Japanese pagodatree leaf 150g, Cortex berberidis dasystachyae 260g, little Rhizoma Coptidis thorn 250g, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 320g, Herba Artemisiae Japonicae 250g, Herba Kyllingae 120g, Folium Mali Asiaticae 250g, Radix spiraeae japonicae 70g, Radix Rubi 250g, Periostracum cicadae 260g and false 190g.

Its preparation method comprises the following steps:

The first step, Radix duchesneae indicae, Rhizoma Humatae Tyermanni, Cremastra appendiculata, Radix Kalopanacis, Ternstroemia gymnanthera, Herba Asparagi Setacei, Concretio silicea Bambusae seu schizostachyi, Japanese pagodatree leaf, Cortex berberidis dasystachyae and little Rhizoma Coptidis thorn is mixed in proportion, add relative to the alcohol reflux that mixture 3 times amount determining alcohol is 65% 2 times, each 3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, standby；

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4 times amount water, boils 4 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.29；

3rd step, the mastic mixing first step, second step obtained, 60 DEG C of reduced vacuum dry, and get dry extract powder；

4th step, carries out mixing process by described dried cream powder and starch, obtains mastic mixture；Described mastic and the weight ratio of starch are 1: 0.01；Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained；

5th step, is sequentially carried out described mastic compound particles and Pulvis Talci, magnesium stearate mixing process, tabletting process, Cotton seeds, obtains Chinese medicinal tablet finished product；Described granule, Pulvis Talci, magnesium stearate weight ratio be 100: 1.6: 0.24.

Embodiment 2: capsule prepared by the present invention

Take Radix duchesneae indicae 230g, Rhizoma Humatae Tyermanni 160g, Cremastra appendiculata 390g, Radix Kalopanacis 220g, Ternstroemia gymnanthera 150g, Herba Asparagi Setacei 260g, Concretio silicea Bambusae seu schizostachyi 180g, Japanese pagodatree leaf 120g, Cortex berberidis dasystachyae 290g, little Rhizoma Coptidis thorn 210g, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 350g, Herba Artemisiae Japonicae 210g, Herba Kyllingae 150g, Folium Mali Asiaticae 210g, Radix spiraeae japonicae 90g, Radix Rubi 230g, Periostracum cicadae 280g and false 160g.

Its preparation method comprises the following steps:

The first step, Radix duchesneae indicae, Rhizoma Humatae Tyermanni, Cremastra appendiculata, Radix Kalopanacis, Ternstroemia gymnanthera and Herba Asparagi Setacei are mixed in described ratio, add the water extraction volatile oil relative to 5 times of mixture, the volatile oil beta-cyclodextrin inclusion compound that will obtain, the ratio of volatile oil and beta-schardinger dextrin-is 1: 4, stirs 80 minutes, temperature 40 DEG C, obtain volatile oil clathrate compound, standby；It is the clear paste of 1.16 that aqueous extract is separately concentrated into relative density when 60 DEG C；

Second step, Concretio silicea Bambusae seu schizostachyi, Japanese pagodatree leaf, Cortex berberidis dasystachyae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Herba Artemisiae Japonicae and Herba Kyllingae are mixed in described ratio, add relative to the alcohol reflux that mixture 6 times amount determining alcohol is 85% 4 times, each 3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into relative density when 60 DEG C is the clear paste of 1.20, standby；

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 9 times amount water, boil 8 hours, filter, and being concentrated into relative density when 65 DEG C is the clear paste of 1.28；

4th step, mixes the clear paste of the first step, second step, the 3rd step, and 65 DEG C of reduced vacuum dry, and get dry extract powder；

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is sufficiently mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, adding 6 weight portion carboxymethyl starch sodium, 30 weight starch mix homogeneously, adding 160 weight portion determining alcohols is 85% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 4 weight portion magnesium stearate, be then charged in gelatine capsule.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 18～36g, carries out acute toxicity test.Mice is randomly divided into two groups, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 8.73g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 43.65 crude drugs/kg), and matched group gives normal saline, within one day, it is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Test result indicate that: compare with matched group, after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Tablet LD50 > 43.65 crude drugs/the kg of the Mouse oral gavage present invention, every day, maximum dosage-feeding was 87.3 crude drugs/kg/ day.The Chinese medicine clinical application amount of the present invention be 8.43g crude drug/day/people, adult body weight in 60KG, average dosage is 0.141g crude drug/kg/ day.By weighing machine: 621 times that the dosis tolerata of the Chinese medicine of mice (average weight with 27g) the oral administration gavage present invention is quantity.Therefore the Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention to three groups of mices (often group 20) by 13.27,25.43 and 42.35g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 3 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by Chinese medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 15 weeks and drug withdrawal 3 weeks, Organs of Mice is all without substantially changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety.

Clinical data:

Case selection: all 152 example cases derive from this Out-patient Department and the herpes simplex keratitis patient being in hospital.All above patient is randomly divided into two groups, treatment group and each 76 example patients of matched group.Wherein, treatment group 76 example, male 41 examples, female 35 example；15～54 years old age；The course of disease 2 days～10 months；Simple eye morbidity 61 example, eyes are fallen ill 15 examples.Matched group 76 example, male 39 examples, female 37 example；16～56 years old age；The course of disease 2 days～9 months；Simple eye morbidity 62 example, eyes are fallen ill 14 examples.Treatment group compares no significant difference (P≤0.01) with matched group in sex, age, the course of disease and clinical symptoms etc., has comparability.

Diagnostic criteria: according to the diagnostic criteria of herpes simplex keratitis in " clinical disease diagnosis and curative effect judging standard " that hospital associate of Hunan Province writes.1, whole body is had to generate heat, preauricular lymph nodes enlargement, the viral infection medical history such as lip or skin bleb.2, cornea dendroid, map shape ulcer stove, or the sign such as plate-like interstitial keratitis.3, lab testing contributes to diagnosis, and as corneal epithelium scraping blade finds multinucleated giant cell, cornea focus is separated to herpes simplex virus, and monoclonal antibody histochemical stain finds virus antigen.Round pcr can detect the viral DNA in cornea, aqueous humor, vitreous body and in tear, is a quick and sensitive detection method of confirmation clinical diagnosis.

Therapeutic Method:

Matched group: give Eye Drops of Ganciclovir eye dripping, instills in eyelid, one time 2, every 2 hours are once, within 1st, are administered 7～8 times；Within 1 week, it is a course for the treatment of, treats two courses for the treatment of.

Treatment group: give Eye Drops of Ganciclovir eye dripping, instills in eyelid, one time 2, every 2 hours are once, within 1st, are administered 7～8 times；Oral Chinese medicine embodiment 1 tablet of the present invention simultaneously, each 3, every day 3 times；Within 1 week, it is a course for the treatment of, treats two courses for the treatment of.

Curative effect judging standard: clinical cure: irritated eyes and congested all disappearances, corneal ulcer heals, and fluorescein sodium is negative staining, and corneal edema disappears, and recovers normal thickness, and kp disappears or becomes brown, and aqueous flare is negative, vision restoration.Effective: irritated eyes and congested basic disappear, corneal ulcer heals substantially, the weakly stained positive of fluorescein sodium, or has shallow-layer point-like painted, and corneal edema disappears substantially, and KP becomes brown, and aqueous flare is negative, vision improve 4 row or more than.Effective: irritated eyes and hyperemia substantially alleviate, corneal ulcer more than 1/2 heal, fluorescein sodium stained positive, corneal edema alleviates, vision improve 2 row or more than.Invalid: to compare with before treatment and be not improved.

Therapeutic outcome: two groups treat 2 weeks respectively after, statistical result is referring to table 1 and table 2.

Clinical efficacy comparison (unit: example) after treating respectively 2 weeks organized by 1 liang of table

Group	n	Clinical cure	Effective	Effectively	Invalid	Total effective rate
							Treatment group	76	47	14	12	3	73 (96.05%)
Matched group	76	27	23	14	12	64 (84.21%)

As it can be seen from table 1 treatment group adopts the Chinese medicine of the present invention, coordinate western medicine herpes simplex keratitis, relative to matched group, on therapeutic effect, have and be markedly improved.

2 liang of table is organized clinical cure number and time after treating 2 weeks respectively and is compared (unit: example/%)

From table 2 it can be seen that treatment group adopts the Chinese medicine of the present invention, coordinate western medical treatment herpes simplex keratitis, relative to matched group, not only better efficacy, takes effect also faster.

Untoward reaction: during treatment, all there is not ophthalmic uncomfortable, hepatic and renal function injure or other untoward reaction in treatment group patient.Matched group has 3 example patients the ophthalmic uncomfortables such as slight blepharoedema, conjunctival congestion, pain occur, hepatic and renal function injure or other untoward reaction does not all occur

Relapse rate is added up: 27 that 47 and matched group for the treatment of group clinical cure are cured are followed up a case by regular visits to 6 months respectively, and result statistics, treatment group is without recurrence, and relapse rate is 0%；Matched group, recurs 5 people, relapse rate 18.52%.

Concrete case: Wei, man, 39 years old, patient before 1 month when orchard work left eye accidentally scratched by leaves, personal chloromycetin eye water spot eye.After 10 days, patient's right eye pain, photophobia, visual deterioration.Local county hospital diagnosis is " bacterial keratitis ", gives " ofloxacin collyrium ", " tobramycin collyrium ", 8 times/day, has no improvement after treating 3 weeks, arrives me subsequently and institute goes to a doctor, diagnoses as " viral keratitis ".Give Eye Drops of Ganciclovir eye dripping, instill in eyelid, one time 2, every 2 hours are once, within 1st, are administered 7～8 times；Oral Chinese medicine embodiment 1 tablet of the present invention simultaneously, each 3, every day 3 times；After treating 10 days, irritated eyes and hyperemia all disappear, and corneal ulcer heals, and fluorescein sodium is negative staining, and corneal edema disappears, and recover normal thickness, kp disappearance, and aqueous flare is negative, vision restoration, clinical cure, follow up a case by regular visits to 6 months without recurrence.

All above-mentioned primary these intellectual properties of enforcement, do not set this new product of enforcement or the new method that limit other forms.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But, all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, and any those skilled in the art are changed or be modified as the Equivalent embodiments of equivalent variations possibly also with the technology contents of the disclosure above.But every without departing from technical solution of the present invention content, according to any simple modification, equivalent variations and remodeling that above example is made by the technical spirit of the present invention, still fall within the protection domain of technical solution of the present invention.

Claims

1. the Chinese medicine treating herpes simplex keratitis, it is characterized in that, described Chinese medicine includes following raw medicinal material: Radix duchesneae indicae, Rhizoma Humatae Tyermanni, Cremastra appendiculata, Radix Kalopanacis, Ternstroemia gymnanthera, Herba Asparagi Setacei, Concretio silicea Bambusae seu schizostachyi, Japanese pagodatree leaf, Cortex berberidis dasystachyae, little Rhizoma Coptidis thorn, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Herba Artemisiae Japonicae, Herba Kyllingae, Folium Mali Asiaticae, Radix spiraeae japonicae, Radix Rubi, Periostracum cicadae and vacation.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Radix duchesneae indicae 15～30 parts, Rhizoma Humatae Tyermanni 15～25 parts, Cremastra appendiculata 30～40 parts, Radix Kalopanacis 10～25 parts, Ternstroemia gymnanthera 5～15 parts, Herba Asparagi Setacei 25～35 parts, Concretio silicea Bambusae seu schizostachyi 15～25 parts, Japanese pagodatree leaf 10～20 parts, Cortex berberidis dasystachyae 15～30 parts, little Rhizoma Coptidis sting 20～35 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 30～40 parts, Herba Artemisiae Japonicae 15～25 parts, Herba Kyllingae 5～15 parts, Folium Mali Asiaticae 20～30 parts, Radix spiraeae japonicae 5～15 parts, Radix Rubi 20～30 parts, Periostracum cicadae 25～35 parts and vacation 15～25 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Radix duchesneae indicae 20～25 parts, Rhizoma Humatae Tyermanni 15～20 parts, Cremastra appendiculata 35～40 parts, Radix Kalopanacis 20～25 parts, Ternstroemia gymnanthera 10～15 parts, Herba Asparagi Setacei 25～30 parts, Concretio silicea Bambusae seu schizostachyi 15～20 parts, Japanese pagodatree leaf 10～15 parts, Cortex berberidis dasystachyae 25～30 parts, little Rhizoma Coptidis sting 20～25 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 30～35 parts, Herba Artemisiae Japonicae 20～25 parts, Herba Kyllingae 10～15 parts, Folium Mali Asiaticae 20～25 parts, Radix spiraeae japonicae 5～10 parts, Radix Rubi 20～25 parts, Periostracum cicadae 25～30 parts and vacation 15～20 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Radix duchesneae indicae 21 parts, Rhizoma Humatae Tyermanni 18 parts, Cremastra appendiculata 36 parts, Radix Kalopanacis 25 parts, Ternstroemia gymnanthera 12 parts, Herba Asparagi Setacei 28 parts, Concretio silicea Bambusae seu schizostachyi 16 parts, Japanese pagodatree leaf 15 parts, Cortex berberidis dasystachyae 26 parts, little Rhizoma Coptidis sting 25 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 32 parts, Herba Artemisiae Japonicae 25 parts, Herba Kyllingae 12 parts, Folium Mali Asiaticae 25 parts, Radix spiraeae japonicae 7 parts, Radix Rubi 25 parts, Periostracum cicadae 26 parts and vacation 19 parts.

5. the Chinese medicine as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

6. the Chinese medicine as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

7. the preparation method of the Chinese medicine described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is tablet, and it comprises the following steps:

8. the preparation method of the Chinese medicine described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps: