CN105748108A - Device - Google Patents
Device Download PDFInfo
- Publication number
- CN105748108A CN105748108A CN201610101022.6A CN201610101022A CN105748108A CN 105748108 A CN105748108 A CN 105748108A CN 201610101022 A CN201610101022 A CN 201610101022A CN 105748108 A CN105748108 A CN 105748108A
- Authority
- CN
- China
- Prior art keywords
- cavity
- moving element
- fluid
- carrier
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48714—Physical analysis of biological material of liquid biological material by electrical means for determining substances foreign to the organism, e.g. drugs or heavy metals
Abstract
The invention relates to a device used for collecting and detecting a fluid sample.The device comprises a first cavity and a second cavity, wherein the first cavity is located in and communicated with the second cavity, and the first cavity and the second cavity can rotate relative to each other, so that fluid is made to flow between the first cavity and the second cavity, and the first cavity is provided with a first position and a second position in the second cavity.By means of the device, fluid in the second cavity can be fully mixed, the purpose of uniformly mixing the fluid is achieved, and thereby it is helpful for subsequent detection.
Description
The application is Chinese invention patent application, application number: the divisional application of 201210409899.3.
Technical field
The present invention relates to a kind of device, especially for the device collecting and detecting fluid sample.
Background technology
Following background technology is adapted to assist in the reader understanding present invention, and is not construed as prior art.
In our society, illicit drug use has had become as a social problem generally acknowledged and increasingly worsen.2003, U.S. Department of Health and Human Service investigation discovery there are about 19,500,000 Americans or 8.2% age crowd more than 12 years old is sucking illicit drugs." use illicit drugs recently " and refer to carry out investigating in the previous moon at U.S. Department of Health and Human Service and use a kind of illicit drugs.Fructus Cannabis is found to be the most frequently used illicit drugs, accounts for 6.2% (14,600,000).Estimating that 2,300,000 people (1.0%) are currently in use cocaine now, 604,000 people employ KUAIKE, have 1,000,000 people to use hallucinogen, and estimate that 119,000 people are currently in use heroin.
US Patent No. 2004/0184954 and US2004/0237674 disclose other and collect saliva and carry out whether containing in detection saliva the device of illicit drugs composition.In the two patent, both provide the apparatus and method collected and detect saliva, in these devices, after sample is sampled on catcher, by applying external force, the sample in absorption piece on catcher is expressed in collecting chamber, then detects again.But, sample collection rod is coordinating in extrusion process with collecting chamber, it is possible to has sample contact and pollutes to operator or infect；Further, when running into sample and needing first and detect after buffer mixing again, such collection device just seems not very convenient.
It is thus desirable to sample is collected and detects by better method and device.
Summary of the invention
The present invention provides new device, it is possible to makes sample and buffer liquid be sufficiently mixed, facilitates next step detection.
On the one hand, the present invention provides a kind of device, this device includes: the first cavity and the second cavity, wherein, first cavity is positioned at the second cavity, and the first cavity and the second cavity are connected, described first cavity and the second cavity can relatively move and make fluid flow between the first cavity and the second cavity.
Preferably, the first cavity and the second cavity fluid are connected, and namely fluid can carry out circulating or transmitting between the first cavity and the second cavity.Including the opening of connection the first cavity and the second cavity on the first cavity, fluid is flowed in the second cavity by this opening.
In some preferred modes, the first cavity has primary importance and the second position in the second cavity.
In the preferred mode of other, when the first cavity is moved to the second position by primary importance relative to the second cavity, space or the volume of the first cavity change, and the change of volume promotes fluid to be flowed into the second cavity from the first cavity.
In some preferred modes, at the first cavity in the process of space or change in volume, make way for the fluid in the first cavity and be flowed in the second cavity.In some modes, the first cavity, in the process of space or change in volume, is made way for the fluid in the first cavity and is irreversibly flowed in the second cavity.
In some preferred modes, the first cavity space and/or change in volume are volume and/or space diminishes.
In some preferred modes, when the first cavity is turned to the second position by primary importance relative to the second cavity, the space of the first cavity diminishes, and makes way for the fluid in the first cavity and be flowed in the second cavity in the process that this space diminishes；Or, when the first cavity is turned to primary importance by the second position, the space of the first cavity returns to original state, and time namely the first cavity is in primary importance, fluid can also be flowed into the first cavity in the second cavity.
In some preferred specific embodiments, the first cavity is by the opening on open sidewall or the first cavity wall and the second cavity configured in fluid communication.In other specific embodiments, this device also includes the moving element of activity, for instance draw-in groove, and moving element is connected the opening on wall can move in the first cavity and allow the first cavity volume diminish.In preferred mode, movable element is positioned at the first cavity.In some modes, when the first cavity is in primary importance relative to the second cavity time, moving element is away from the first cavity, in time moving relative to the second cavity, in the process of movement, moving element moves closer to or enters in the first cavity, extrude the first cavity or enter the first cavity allow the volume of the first cavity change, for instance diminishing, the change of volume make way for the fluid in the first cavity from the first cavity stream to the second cavity.In some modes, a part for movable draw-in groove is positioned in the opening of wall of the first cavity, another part of draw-in groove and the contact internal walls of the second cavity, the first cavity allows draw-in groove be entered into by opening relative to the movement of the second cavity to allow the volume of the first cavity diminish in the first cavity.
In one embodiment, moving element, for instance on draw-in groove, there is the projection coordinated with the second cavity, when the first cavity and the second cavity rotate, the second cavity promotes projection to make moving element move to the first inside cavity, thus allowing the volume of the first cavity diminish.In some modes, the first cavity includes two symmetrical openings, is in fluid communication by this opening and the second cavity, correspondingly, includes two symmetrical mobilizable moving elements or draw-in groove on two symmetrical openings.When the first cavity is mobile in the second cavity time, symmetrical moving element enters in the first cavity or allows the volume of the first cavity change in extruding the first cavity, for instance diminishes, makes way for the fluid in the first cavity and be flowed in the second cavity.In some modes, symmetrical moving element, such as draw-in groove, between flexible member can be installed, for instance spring, it is in process close to each other, the spacing of draw-in groove reduces, thus allowing the first cavity volume reduce, or directly compression is positioned at the fluid sample absorption carrier in the first cavity, otherwise, then increase the volume of the first cavity or reduce the compression to carrier.
In some preferred modes, it is positioned at the carrier adsorption that the fluid sample of the first cavity can be extruded or compress, in its natural state, fluid sample is attracted in carrier, without flowing, when carrier is compressed time, the fluid sample being positioned on carrier is squeezed out outside carrier.Some embodiments in conjunction with top, owing to the volume of the first cavity there occurs change, such as reduce, it is possible to extruding is in carrier in the first cavity, thus allowing the fluid on carrier by slit flow reserved between draw-in groove and the first cavity wall upper shed in the second cavity.In some preferred modes, movable draw-in groove directly extrudes the carrier being adsorbed with fluid sample.
In other embodiments, this device also includes sample collection rod, collects the carrier that rod includes being compressed.This carrier that can be compressed has fluid sample for absorption or collection.In some specific embodiments, sample collection rod coordinates with the first cavity, enables the first cavity and the second cavity mutually to rotate.
In specific embodiment, moving element includes allowing fluid flow into the passage of the second cavity from the first cavity.Namely draw-in groove has the groove that fluid can be allowed to flow, is flowed in the second cavity in the first cavity by fluid by groove.
In another specific embodiment, draw-in groove has the card article that can coordinate with the first cavity wall.
In other embodiments, this device also includes the 3rd cavity being connected with the first cavity and connecting.In preferred mode, the first cavity and the 3rd cavity are fixed and are connected, it is possible to allow the first cavity and the 3rd cavity move in the second cavity together simultaneously.In preferred mode, the 3rd cavity lateral wall has puncturing elements, for instance lamellar is protruding.Being more highly preferred to, lamellar projection is positioned at the monosymmetric position in the 3rd chamber.In some embodiments, this device also includes the seal being punctured equipped with fluid or buffer fluid (buffer solution), and this seal is between the second cavity and the 3rd cavity.The functions such as fluid or buffer fluid mainly process fluid sample, for instance dilution, and eluting extracts, the impurity in removing fluid sample.The seal that can be punctured can be had lamellar projection on the 3rd cavity lateral wall and be punctured.
In other mode, the seal that can be punctured is positioned at the first cavity, seal can be punctured when draw-in groove enters the moving process of the first cavity, thus discharging fluid therein, this fluid can be directly entered in the second cavity, can also mix with the fluid sample on carrier, the fluid sample etc. on eluting carrier, be flowed into together in the second cavity then as fluid sample.
In some specific embodiments, the first cavity also includes the 3rd position in the second cavity；When the first cavity is turned to three positions by the second position, size is recovered in the space of the first cavity, and fluid is flowed into the first cavity in the second cavity；When the first cavity is turned to the second position by the 3rd position, the space of the first cavity diminishes, and fluid is flowed into the second cavity from the first cavity.
Some preferred embodiment in, when the first cavity is turned to the second position or four positions by primary importance or the 3rd position, two draw-in grooves move to the inside of the first cavity so that it is space diminishes, extruding is positioned at the carrier of the first cavity, and makes fluid be flowed into the second cavity from the first cavity.
More specifically in embodiment, when the first cavity by the second position turn to primary importance by or when the 4th position moves to three positions, carrier makes two draw-in grooves be displaced outwardly by the first inside cavity, original state is recovered in the space making the first cavity, such as volume is the same with primary importance, and makes fluid be flowed into the first cavity from the second cavity again.
In another specific embodiment, the first cavity also includes the 4th position in the second cavity；When the first cavity is turned to four positions by primary importance or the 3rd position, the space of the first cavity diminishes, and fluid is flowed into the second cavity from the first cavity.
In another embodiment, when the first cavity moves primary importance or three positions from four-position rotation, size is recovered in the space of the first cavity, and fluid is flowed into the first cavity from the second cavity.
In some specific embodiments, when the first cavity is turned to the second position or four positions by primary importance or the 3rd position, lamellar projection pokes the seal being positioned between the second cavity and the 3rd cavity.
In other embodiments, this device also includes the test chamber containing testing element, this test chamber and the second cavity configured in fluid communication.
In the present invention, in order to allow the first cavity relative motion in the second cavity, allow the moving element being between the first cavity and the second cavity, such as movable draw-in groove, enter or removal the first cavity, thus allowing the volume of the first cavity change, the fluid made way in the first cavity that the change of volume can be direct or indirect, such as fluid sample, is flowed into the second cavity from the first cavity.In some modes, the mode of movement is rotating manner.This mode being mutually shifted is when arranging, as long as allow moving element when the first cavity is in primary importance with the first cavity be in the second position time, moving element there occurs change in the position on the first cavity, for instance closer to or deeper into just passable in the first cavity.Such as, on the second cavity inner wall line distance between any the first two for a and additionally line distance between any the second two be b, wherein a is more than b, and the distance sum between length and the moving element of moving element itself is c, and wherein c is more than b.So, when moving element moves to shorter line from other position time, owing to, on the line that the length of moving element itself is shorter more than the second cavity with the length of their spacing, so necessarily making the distance between moving element reduce, the minimizing of distance can compression vehicle.In some preferred modes, on moving element be in the second cavity when primary importance any longer line of the first two, for instance line a；When moving element is in the second position time, moving element is in the second cavity additionally on the line length b of any the second two.Such setting is except arranging the second irregular shape of cavity, this mode allowing moving element position change can be set projection or recessed parts at the inwall of the second cavity, allow the line between the second cavity inner wall arbitrfary point apart from unequal, thus can realize the movement of moving element, change the distance between moving element.In some preferred modes, the movement of the mobile drive moving element of the first cavity or transfer.In preferred mode, the movement driving moving element of the mobile synchronization of the first cavity, for instance moving element is attached in the first cavity.
In other embodiments, second cavity is Elliptic Cylinder, first cavity is rectangular structure, when the first cavity is in primary importance time, the distance of moving element is on the range line that Elliptic Cylinder is the longest, when the first cavity is in the second position time, the distance of moving element is on the range line that Elliptic Cylinder is the shortest.
On the other hand, in the preferred mode of other, the present invention provides a kind of device, when the first cavity is moved to the second position by primary importance relative to the second cavity, space or the volume of the first cavity do not change, and the moving element made way between the first cavity and the second cavity moves, the moving element compression of movement is positioned at the carrier that can be compressed in the second cavity, makes way for the fluid sample on carrier and is flowed in the second cavity.
Such as, in a specific embodiment, the present invention provides a device that, this device includes: the first cavity and the second cavity, wherein, the first cavity is positioned at the second cavity, and the first cavity and the second cavity are connected, and the moving element between the first cavity and the second cavity, described first cavity and the second cavity can relatively move and make the distance between moving element reduce.
In a preferred mode, between moving element, it is provided with the carrier that can be compressed being adsorbed with liquid sample.Compression vehicle after distance minimizing between moving element.In some preferred modes, piecemeal activity element is positioned on the first cavity, and the rotation in the second cavity of first cavity drives moving element to move.The movement of this moving element is the motion entering the first cavity, and in the present embodiment, the carrier that can be compressed can be located in the first cavity in advance, and when moving element enters the first cavity in opposite directions time, compression vehicle allows the liquid sample in carrier flow out.In some preferred modes, the first cavity includes some openings, and moving element is entered in the first cavity by opening.Certainly, in some preferred modes, the compressible carrier being adsorbed with fluid sample may be located on fluid specimen collection device, first collect fluid sample with carrier, mouth such as, is collected saliva, be then inserted in the first cavity, allow carrier between moving element or, the position can compressed by moving element.
Such as, it is provided that a kind of device, including: for housing the first cavity that compressible collection has the carrier of liquid sample；Second cavity, and the moving element between the first cavity and the second cavity, wherein, first cavity is positioned at the second cavity, and the first cavity and the second cavity fluid are connected, first cavity drives moving element to rotate in the second cavity, the carrier in rotary compression first cavity of moving element.
Including opening on the wall of the first cavity, one end of moving element is positioned at the first cavity through opening, and the other end is near the inwall of the second cavity.
Described moving element is two and is oppositely arranged, and the moving element being oppositely arranged has the first distance in primary importance and the second distance in the second position, and wherein the first distance is more than second distance.When moving element is positioned at primary importance time, moving element is on the second inside cavities wall on line between the first two；When moving element is positioned at the second position time, moving element on the second inside cavities wall on line between the second two, wherein the distance between the first two more than the second two between distance.
The carrier that can be compressed is between the moving element that opposition is arranged.This device also includes sample collection rod, collects the carrier that rod comprises described collection fluid sample.Described sample collection rod coordinates with the first cavity, drives the first cavity to rotate in the second cavity.The rigidity of moving element is more than the rigidity of compressible carrier.
Moving element moves to the second position from primary importance, and the distance between the moving element that opposition is arranged reduces, and collecting, thus compressing, the carrier having fluid sample, allowing fluid sample be flowed in cavity from carrier.
Described fluid is entered in the second cavity by the opening on the inwall of the first cavity.
On the other hand, the present invention provides a kind of detection method, including: providing one detection dress, this detecting device includes the second cavity and is positioned at the first cavity of the second cavity kind, and this first cavity is used for housing fluid sample；Allow the first cavity rotate relative to the second cavity, allow the volume of the first cavity change by rotating；Wherein, the change of this volume allows the fluid sample in the first cavity enter in the second cavity.In some preferred modes, this detecting device includes moving element, and the first cavity drives moving element to rotate in the second cavity, and the rotation of moving element allows the volume of the first cavity reduce.It is furthermore preferred that described fluid sample is attracted on compressible carrier, described carrier is compressed in the rotation of moving element.Preferably, the rotation of moving element allows moving element compress described carrier.
Beneficial effect
Assembly of the invention can simpler collection fluid sample, conveniently storage and transport；It addition, the fluid in the first cavity flows in the second cavity fully, and making the fluid being positioned at the second cavity be sufficiently mixed, particularly sample and buffer liquid can be sufficiently mixed, and reach the purpose of fluid mix homogeneously, thus being more beneficial for next step detection.
Accompanying drawing explanation
Fig. 1 is the schematic perspective view of a device of the present invention；
Fig. 2 is the sectional view of apparatus of the present invention；
Fig. 3 is the explosive decomposition figure of apparatus of the present invention；
Fig. 4 is the schematic diagram of moving element draw-in groove in apparatus of the present invention；
Fig. 5 is the schematic diagram of the another side of moving element draw-in groove in apparatus of the present invention；
Fig. 6 is the first cavity and the 3rd cavity schematic diagram in apparatus of the present invention；
Fig. 7 is the sample collection rod schematic diagram of the present invention；
Fig. 8 is the connection diagram of apparatus of the present invention the second cavity and detecting device；
Fig. 9 is the position relationship schematic diagram (primary importance or the 3rd position) of the first cavity and the second cavity；
Figure 10 is one view of apparatus of the present invention (primary importance or the 3rd position)；
Figure 11 is the A-A profile schematic diagram of Figure 10 state；
Figure 12 is another view of apparatus of the present invention (second position or the 4th position)；
Figure 13 is the A-A profile schematic diagram of Figure 12 state；
Figure 14 is the schematic diagram of one embodiment of the present invention.Figure 14 A represents that the first cavity is in initial first position, and moving element 51 is initial position, and Figure 14 B represents that the first cavity is in the second position, and moving element 51 moves and compression vehicle in the first cavity.From this figure, it can be seen that due to the setting different with position relationship with the shape of the first cavity of the shape of the second cavity, along with relative movement, thus allowing the position of moving element change, finally allow the direct compression vehicle of moving element discharge fluid sample.
Figure 15 is the schematic diagram of one embodiment of the present invention.Figure 15 A represents that the first cavity is in initial first position, and moving element 51 is initial position, and Figure 15 B represents that the first cavity is in the second position, and moving element 51 moves and compression vehicle in the first cavity.Although from this figure, it can be seen that allowing moving element move and compression vehicle owing to the shape of the second cavity does not have to change different with first cavity position relationship in the second cavity.Along with relative movement, thus allowing the position of moving element change, the direct compression vehicle of moving element is finally allowed to discharge fluid sample.
Description of reference numerals:
nullSample collection and detecting device 500，Assembly of the invention 510，Sample collection rod 520，Detecting device 530，First cavity 512，The sidewall of the first cavity opening or the opening 5121 of sidewall，The sidewall 5122 of the first cavity，Second cavity 511，3rd cavity 513，Draw-in groove 515，Draw-in groove projection 5151，Card article 5152 on draw-in groove，Draw-in groove upper groove 5153，Packing ring 516，Second cavity upper cover 517，Second cavity bottom pad 518，Buffer seal 5132，3rd cavity lateral part projection 5131，3rd inside cavities wall projection 5133，The portion of being affectedly bashful 521 of sample collection rod，The carrier 522 of sample collection rod，It is affectedly bashful the connecting rod 523 in portion and carrier，It is affectedly bashful portion's groove 524，Detecting device upper plate 531，Detecting device lower plate 532，Detecting device is in the projection 533 of apparatus of the present invention corresponding position，Primary importance 801，The second position 802，3rd position 803，4th position 804；Moving element 51；
Detailed description of the invention
Below the structure that the present invention relates to or these technical terms used are described further.
Sample
" sample " that the present invention refers to refers to any material needing chemical examination whether to there is and (or) analyze analyte concentration, or it needs to be determined that whether one or more samples exist and (or) the material of the analyte of quantity, or need to carry out the material of qualitative evaluation.Sample can be fluid sample, for instance fluid sample.Fluid sample includes body fluid, such as blood, serum, blood plasma, saliva, urine, tear, seminal fluid and bone marrow；Fluid sample can also be water sample, such as sea water, river, river etc., or from domestic water, municipal water use or industry water resource, runoff water or sewage；Sample can be food sample, such as milk and wine.Mucus, semisolid or solid sample can be used to make fluid, eluate, suspension or leachate equal samples.Such as, throat or genitals sample may be dipped in and make sample in fluid.Sample can include mixture or any relevant mixture, the cell suspending liquid in such as diluent or solution of fluid, solid and gas.Sample includes biological substance, such as cell, microorganism, organelle and biochemical complexes.Fluid sample solid, semisolid or the high-viscosity material such as nonfluid sample can be produced from such as soil, feces, tissue, organ, biological fluid or other nature.Such as, these solids or semi-solid samples can mix by the solution suitable with diluent one class.Sample can be macerated, freezing and defrosting, or other extracting method form fluid sample.Remaining particulate material can use the method that filtration or precipitation etc. are traditional to remove.
Testing element
" testing element " is any element performing test.In one embodiment, testing element is test strip.This test strip may be included on it has specific binding material pair for immunoassay.Test strip can be a kind of change by color upon completion of the assays or the test chemical bar of other signal intensity judged results.It is suitable for the sample that the present invention carries out detecting and includes but not limited to body fluid, the sample separated from biological tissue or body fluid.Such as, sample can be saliva, blood, serum, blood plasma, urine, Excreta, spinal fluid, vaginal secretion, mucus and tissue.Testing element is not limited to one, it is possible to be that two or more testing element is arranged in detecting device simultaneously, respectively different component in test sample.
Sample collection rod 520
The present invention also provides for sample collection rod 520.In one embodiment, sample collection rod 520 has an absorption carrier 522 and is affectedly bashful portion 521.Absorb carrier 522 to be generally made up of the other sponge of medical grade commonly used in the art or plastic foam material.But many other materials may be made as absorbing carrier, for instance Cotton Gossypii or paper, or other any materials with water absorbing properties.Absorb carrier 522 there is certain elasticity, when being subject to external force pressure, can compression stroke and diminish, and when external force reduce or disappear time, absorb carrier can progressively restore to the original state.Sample collection rod can soak containing stimulating in the salivary solution of tester in advance.So that be easier to collect saliva when collecting rod and putting in tester's mouth.The portion of being affectedly bashful is usually rigidity, is conducive to the operation absorbing carrier.The portion of being affectedly bashful can be made up of material commonly used in the art, for instance plastics, timber, metal or cardboard.
In the following detailed description, the subsidiary reference word of legend is a part here, and it is to illustrate that the present invention can illustrate in the way of actable specific concrete scheme.We are not precluded from the present invention and can also carry out other concrete scheme and change the structure of the present invention when without prejudice to the use scope of the present invention.
As shown in figure 14, in a specific embodiment of the present invention, in the second cavity 510, include carrier 522 and the moving element 51 being correspondingly arranged with carrier, now moving element is in primary importance relative to the second cavity, during this time, moving element is compression vehicle not, Figure 14 A.Distance H and the length (A+B) of moving element itself between this time moving element are on the axis C of the second cavity length.When along the direction of arrow rotary moveable element time, moving element is close to centre due to the pressure being subject to the second cavity inner wall, compression vehicle, the fluid sample in carrier is allowed to be compressed out from carrier, Figure 14 A, this time, moving element was on the axis D that the second cavity is short, the wherein length of the C length more than D.
Equally, in fig .15, moving element is in the distance that the interior arbitrfary point line of the second cavity is longer when primary importance, this time moving element not compression vehicle, when rotary moveable element time, moving element moves to the position that the interior arbitrfary point line of the second cavity is shorter from the position that the interior arbitrfary point line of the second cavity is longer, this time moving element compression vehicle, thus the fluid on carrier is compressed out.Equally, in above specific embodiment, carrier can be placed later, corresponding with the position of moving element；It addition, carrier and moving element can also be housed in the first cavity, the wall on the first cavity being opened some openings, allow one end of moving element be positioned in the first cavity, the other end is positioned in the second cavity and close with the inwall of cavity.Here, moving element has more rigid for carrier, so can be effectively compressed carrier.
In mode described in Figure 14 and 15, carrier may be accommodated in the first cavity, the contact that moving element can be direct or indirect by the carrier in the opening of the first cavity and the first cavity.The movement of such moving element can allow the volume of the first cavity reduce and compression vehicle or directly contact carrier and compression vehicle, thus allowing the carrier extruding carrier being adsorbed with fluid sample.
In other specific embodiment, as it is shown on figure 3, in an embodiment, this device 510 includes the first cavity 512 and the second cavity 511, and wherein, the first cavity 512 is positioned at the second cavity 511, as shown in Fig. 2 sectional view, and the first cavity 512 is connected with the second cavity 511.In a specific embodiment, the two is connected by the opening 5121 on the first cavity wall.The shape of the first cavity 512 and the second cavity 511 is not limit, have only to meet the second cavity 511 can hold the first cavity 512 and ensure the first cavity 512 can rotation freely in the second cavity 511, such as: cylinder, cube shaped, cuboid-type, and cone etc..As shown in Figure 6, the first cavity 512 is the structure of cuboid, and in four sidewalls, it is open for having two corresponding sidewalls 5121, and namely symmetrical both sides are without sidewall.And the second cavity 511 is Elliptic Cylinder structure, inner hollow, and, the minor axis of this Elliptic Cylinder is sized slightly larger than the length and width of the cuboid of the first cavity.First cavity 512 is connected by the sidewall 5121 of the opening on the first cavity with the second cavity 511.More specifically, when the first cavity 512 and the second cavity 511 rotate mutually, fluid in first cavity 512 is flowed in the second cavity 511 by the sidewall 5121 that the two is open, or, the fluid in the second cavity 511 is flowed in the first cavity 512 by the two sidewall 5121.
First cavity 512 is free to rotate in the second cavity 511, and, when two cavitys rotate mutually, the fluid in two cavitys can be flowed mutually by mutually rotating of cavity.In some specific embodiments, when the first cavity 512 rotates in the second cavity 511, there is primary importance 801 and the second position 802 relative to the second cavity 511, as shown in Figure 9.When the initial position of the first cavity and the second cavity is primary importance 801, namely when the first cavity is positioned at the primary importance 801 of the second cavity, for original state.And when the first cavity 512 is turned to the second position 802 by primary importance 801, the space of the first cavity 512 diminishes, fluid is flowed into the second cavity 511 from the first cavity 512.Because the space in the first cavity 512 diminishes, the fluid that intracavity holds also will tail off, and therefore, originally the fluid in the first cavity 512 is flowed in the second cavity 511 by its open medial wall 5121.And when the first cavity 512 is proceeded to primary importance 801 by the second position 802, namely during initial position, then original size is recovered in the interior space of the first cavity 512.Now, the fluid in the second cavity 511 is then flowed in the first cavity 512 again through open medial wall 5121.Thus, the fluid in first, two cavitys achieves circulation intercommunication.In other further embodiments, first cavity 512 also includes the 3rd position 803 and the 4th position 804 in the second cavity 511, also shown in FIG. 9,3rd position is positioned at after the second position 802 along 803 times, 4th position 804 is positioned at after the 3rd position 803, and namely the 4th position 804 is primary importance 801 below.In specific embodiment, when the first cavity 512 is turned to three positions 803 by the second position 802, size is recovered in the space of the first cavity 512, and fluid is flowed into the first cavity 512 in the second cavity 511；When the first cavity 512 is turned to the second position 802 by the 3rd position 803, the space of the first cavity 512 diminishes, and fluid is flowed into the second cavity 511 from the first cavity 512.And when the first cavity 512 is turned to four positions 804 by primary importance 801 or the 3rd position 803, the space of the first cavity 512 diminishes, fluid is flowed into the second cavity 511 from the first cavity 812.
In some embodiments, sidewall 5121 place in the opening of the first cavity, there are two corresponding moving elements, such as movable draw-in groove 515, the two draw-in groove position is mobilizable, and the height of draw-in groove 515 is highly identical with open medial wall 5121, when original state, draw-in groove 515 is positioned at sidewall 5122 edge, and a part is positioned at the second cavity 511.As shown in Figure 4 and Figure 5, draw-in groove 515 has the card article 5152 coordinated with the first cavity wall 5122, this card article 5152 with draw-in groove 515 for being flexibly connected, so, card article 5152 has field on draw-in groove 515, the end of card article 5152 has dogleg section, and when initial position, draw-in groove 515 is buckled on the sidewall 5122 of the first cavity by this dogleg section.In the bottom of draw-in groove 515, there is groove 5153, the fluid in first cavity 512 and the second cavity 511 can be made by this groove 5153 mutually to circulate.Additionally, the top of this draw-in groove 515 has protruding 5151, when draw-in groove 515 is positioned at the initial position 801 of the first cavity 512, prominent projection 5151 is positioned at the second cavity 511.nullIn some embodiments，When the first cavity 512 and the second cavity 511 rotate，It is positioned at the draw-in groove 515 of the first cavity 512 to follow the first cavity 512 and rotate，When turning to certain position，Projection 5151 on draw-in groove 515 touches the medial wall of the second cavity 511，When being further continued for rotating，Protruding 5151 are oppressed by the second cavity 511 medial wall，Owing to the sidewall of the second cavity is fixing，And the position that draw-in groove 515 is in the first cavity 512 is moveable，Thus including the draw-in groove 515 of protruding 5151 because of the stop of the second cavity 511 medial wall and pressure，Card article 5152 is whole to be compressed inwardly，Dogleg section departs from the sidewall 5122 of the first cavity，Draw-in groove 515 is internal mobile to the first cavity 512，Extrude the first cavity 512 inner space，Its space is made to diminish.When the first cavity 512 arrives and is positioned at the second position 802 or four positions 804 of the second cavity 511, now, the projection 5151 of draw-in groove is sitting at the minor axis place of the second cavity 511 of Elliptic Cylinder, and now, namely draw-in groove 515 is positioned at the first cavity 512 deepest inside.In one specific embodiment, now, the inner space of the first cavity 512 is all taken by two draw-in grooves 515, and namely two draw-in grooves 515 contact with each other.Now, the groove 5153 being arranged on the fluid of the first cavity 512 open sidewall 5121 by the first cavity and draw-in groove is flowed into the second cavity 511.Then when relative second cavity 511 of the first cavity 512 rotates again, structure due to Elliptic Cylinder, projection 5151 on draw-in groove is moved to major diameter place by the minor axis of Elliptic Cylinder, namely protruding 5151 are discharged by the medial wall of the second cavity gradually, and draw-in groove 515 slowly ejects from the first cavity 512 is internal.When the first cavity 512 turns to the 3rd position 803 or primary importance 801, namely draw-in groove 515 faces the major diameter place of the Elliptic Cylinder of the second cavity 511, draw-in groove 515 ejects completely from the first cavity 512, card article 5152 on draw-in groove after ejection also recovers elastic automatically, its dogleg section is snapped on the medial wall 5122 of the first cavity again, thus draw-in groove 515 returns to original position.
In one specific embodiment, first cavity 512 also comprises the 3rd cavity 513,3rd cavity 513 is connected with the first cavity 512, and, first cavity 512 is connected with the inner chamber body of the 3rd cavity 513, to ensure that sample collection rod 520 can pass through the 3rd cavity 513 and arrive in the first cavity 512.As shown in Figure 6, one more specifically in embodiment, the 3rd cavity 513 is the cylinder of hollow, is fixedly connected on the first cavity 512.On the lateral wall of the 3rd cavity, comprising the lamellar projection 5131 of symmetry, more specifically, projection 5131 position of the 3rd cavity is corresponding above the unopened sidewall 5122 of the first cavity, as shown in Figure 6.In one embodiment, the 3rd cavity 513 is similarly positioned in the second cavity 512, and, in the space that the 3rd cavity 513 and the second cavity 511 are formed, also lay a seal 5132.The one side of this seal 5132 is made up of the aluminium foil that can poke.Fluid reagent it is sealed with in seal.In one specific embodiment, this fluid reagent is buffer solution.When the first cavity 512 rotates in the second cavity 511, it is fixed on the 3rd cavity 513 on the first cavity 512 and rotates in the second cavity 511 along with the first cavity 512,3rd cavity 513 in being turned to the process of the second position 802 of the second cavity 511 by primary importance 801, lamellar projection 5131 on 3rd cavity can touch and because of the aluminium foil of pressure extrusion seal 5132 in rotation, thus poking aluminium foil, the buffer solution in seal 5132 is made to be flowed in the second cavity 511.Further, meanwhile, the fluid in the first cavity 512 is flowed in the second cavity 511 because of the extruding of draw-in groove, and this fluid mixes in the second cavity 511 with buffer solution.
In some embodiments, this device also includes sample collection rod 520, as it is shown in fig. 7, this sample collection rod 520 includes the portion of being affectedly bashful 521, that collects sample absorbs carrier 522 and by the connecting rod 523 of the two connection.In practical operation, the carrier 522 of sample collection rod is put into collection sample in the oral cavity needing tester, then, the rod 520 of collecting collecting full sample is put into the 3rd cavity 513 and finally made the carrier 522 of collection rod be entirely located in the first cavity 512.Some are more specifically in embodiment, and sample collection rod 520 is combined closely with the 3rd cavity 513, and, sample collection rod 520 is rotation in the second cavity 511 together with the 3rd cavity 513 and the first cavity 512.As shown in Figure 6 and Figure 7, in the portion of being affectedly bashful 521 of sample collection rod, there is groove 524, and on the medial wall of the 3rd cavity 513, have matched projection 5133, after in sample collection rod 520 insertion the 3rd 513 and the first cavity 512, groove 524 is mutually clamped with protruding 5133, makes sample collection rod 520 be fixed in the 3rd cavity 513 and the first cavity 512.nullWhen the first cavity 512 is turned to the second position 802 or four positions 804 by primary importance 801 or the 3rd position 803，When namely sample collection rod 520 is turned to the second position 802 or four positions 804 by primary importance 801 or the 3rd position 803 together with the 3rd cavity 513 and the first cavity 512，Interior two draw-in grooves 515 of first cavity 512 move to the inside of the first cavity 512 under the extruding of the second cavity 511，Its space is made to diminish，Thus extruding is positioned at the carrier 522 of the first cavity 512，Now，Carrier 522 is collected and has fluid sample，Such as saliva，Carrier 522 is extruded compression，The saliva being arranged in carrier 522 is just flowed out from carrier，It is flowed in the second cavity 511 by the groove 5153 on the sidewall 5121 of the opening of the first cavity and draw-in groove.Meanwhile, due to the rotation of the 3rd cavity 513, the lamellar projection 5131 on the 3rd cavity lateral wall pokes the seal 5132 between the second cavity 511 and the 3rd cavity 513, and the buffer solution in seal is also flowed in the second cavity 511.Buffer solution mixes in the second cavity 511 with saliva.In order to make the two mixing more abundant, by sample collection rod 520 and the 3rd cavity 513, first cavity 512 is turned to primary importance 801 or the 3rd position 803 by the second position 802 or the 4th position 804 again, now from the distress resolves of the second cavity 511 sidewall on draw-in groove 515, also the carrier 522 that no longer extruding sample collection is excellent, carrier 522 is due to the original size of elastic return, thus carrier 522 makes two draw-in grooves 515 be displaced outwardly by the first cavity 512 is internal, size is recovered in the space finally making the first cavity 512, and, the mixed liquor loaded body 522 being arranged in the second cavity 511 absorbs, it is flowed into the first cavity 512 from the second cavity 511.
In another specific embodiment, this device changes and includes test chamber 530, as shown in Fig. 1, Fig. 3 and Fig. 8.Test chamber 530 is made up of upper cavity 531 and lower chamber 532, can place testing element in the middle of two cavitys.On upper cavity 531, having protruding 533, this projection 533, for coordinating with bottom the second cavity 511, makes the fluid in the second cavity 511 be flowed in test chamber 530.Specifically, having a hole bottom the second cavity 511, pad 518 is positioned at Shang Bingshi hole, hole and seals.Test chamber 530 projection 533 can poke pad 518.Additionally, this projection 533 is corresponding to the sample application zone of testing element in test chamber 530.Protruding 533 is hollow, an aperture is had on protruding 533 tops, when, behind protruding 533 bottoms being inserted into the second cavity 511, the projection 533 that the mixed liquor in the second cavity 511 is flowed into hollow by the aperture of protruding 533 is internal, and then is flowed in the test chamber 530 corresponding with projection.
Below a complete operating process is described with regard to assembly of the invention 500.As shown in Figure 1, Figure 2 and Figure 3, first cavity 512 of cuboid is fixed together with the 3rd cylindrical cavity 513, two draw-in grooves 515 are positioned at sidewall 5121 place of the opening of the first cavity, the bending part of two card articles 5152 on each draw-in groove 515 is fastened on sidewall 5122 place of the first cavity, as shown in Figure 11 profile, wherein, projection 5151 part of draw-in groove is positioned at open sidewall 5121 top, and the groove 5153 of draw-in groove is positioned at the bottom of open sidewall 5121.The bottom of the first cavity 512 is positioned at the bottom of the second cavity 511, and a trumpet type groove is arranged at the bottom of the second cavity 511, facilitates the rotation therein of the first cavity 512.Being a circular hole at the osculum place of loudspeaker, circular hole has a rubber washer 518, this packing ring 518 diameter is identical with Circularhole diameter or is a bit larger tham Circularhole diameter, to seal circular hole.Having the lamellar projection 5131 of symmetry on the 3rd cavity 513, as shown in Figure 3 and Figure 6, lamellar projection 5131 is 4,2, every limit, and this projection 5131 is positioned at above the sidewall 5122 of the first cavity.Accent place at the 3rd cavity 513, it is connected to seal washer 516, packing ring 516 has the upper cover 517 closely sealed with the second cavity 511, so, 3rd cavity 513 and the first cavity 512 are sealed in the second cavity 511, to ensure that the fluid being positioned at these cavitys can not leak.Certainly, between the second cavity 511 and the 3rd cavity 513, also including a seal 5132 with buffer solution, this seal 5132 is positioned at the side protruding without lamellar of the 3rd cavity 513, namely is positioned at the major diameter place of the second cavity 511.Further, seal 5132 has the one side of the aluminium foil that can poke facing to the 3rd cavity 513.As shown in Figure 3 and Figure 7, the portion of being affectedly bashful 521 of sample collection rod 520 has the oval shape that the upper cover 517 with the second cavity matches.
First, operator holds the portion of being affectedly bashful 521 of sample collection rod, is partially placed in the mouth needing tester by the carrier 522 collecting rod, sucks 1-5 minute, make absorption carrier 522 be full of saliva sample.Then, the carrier end of sample collection rod 520 is inserted perpendicularly in apparatus of the present invention down, now, the carrier 522 collecting rod is positioned in the middle of two draw-in grooves 515 of the first cavity 512, as shown in figure 11, the groove 524 collected in the connecting rod 523 of rod engages with the projection 5133 inside the 3rd cavity 513, makes collection rod 520 and the 3rd cavity 513 and the first cavity 512 be fixed together.Further, the upper cover 517 in the portion of being affectedly bashful 521 and the second cavity of collecting rod is fully integrated together, as shown in Figure 10.Now sample collection rod 520 and the 3rd cavity 513 and the first cavity 512 are positioned at the primary importance 801 of the second cavity 511, i.e. initial position, its state is as shown in Figure 10 and Figure 11.
Then, that pins sample collection rod 520 is affectedly bashful position 521, as it is shown in figure 9, rotate sample collection rod 520 by primary importance 801 to the second position 802.In the process rotated, the projection 5151 of draw-in groove 515 touches the medial wall of the second cavity 511 and is extruded by the medial wall of the second cavity 511 gradually, when pressure reaches after to a certain degree, the card article 5152 on draw-in groove 515 is extruded retraction, and then draw-in groove 515 is internal mobile to the first cavity 512.Draw-in groove 515 compressing moved inward is positioned at the absorption carrier 522 of the sample collection rod 520 of the first cavity 512.The saliva sample being arranged on carrier 522 is discharged from carrier 522 after being extruded, and is flowed in the first cavity 512, and is flowed in the second cavity 511 by the open sidewall 5121 of the first cavity and the groove 5153 of draw-in groove.When sample collection rod 520 turns to the second position 802 of the second cavity 511, as shown in figure 12, the upper cover 517 one-tenth plumbness of portion of being affectedly bashful 521 and second cavity 511 of sample collection rod.Now, draw-in groove 515 is because being positioned at the second cavity 511 diameter the shortest (minor axis place) place, and pressure experienced is maximum, and draw-in groove 515 is internal completely into the first cavity 512, is compressed to minimum by carrier 522.Saliva sample on carrier 522 is discharged completely and flows ultimately in the second cavity 511.As shown in Figure 13 profile, now the card article 5152 of draw-in groove 515 is positioned at draw-in groove 515, and two draw-in grooves 515 are fully located in the first cavity 512.Simultaneously, turn in the process of the second position 802 of the second cavity 511 at sample collection rod 520,3rd cavity 513 is same to be rotated in the second cavity 511, thus the seal 5132 being positioned at the second cavity 511 major diameter place touches the lamellar projection 5131 on the 3rd cavity 513, because of the restriction in space, the aluminium foil part of the protruding 5131 crush seal bodies 5132 of lamellar is also poked.Buffer solution in seal 5132 is flowed out by the aluminium foil opening being punctured, and finally flows in the second cavity 511, mixes with the saliva sample being flowed in the second cavity 511 in the first cavity 512.
In order to make saliva sample and the mixing of buffer solution fully, then the sample collection rod 520 that will be located in the second position 802 turns to the 3rd position 803, as shown in Figure 9.Now, the state of sample collection rod 520 and the second cavity 511 is as shown in Figure 10.In the process rotated, draw-in groove 515 in first cavity 512 leaves the minor axis of the second cavity 511 gradually, move to major diameter direction, the pressure that second cavity 511 medial wall is brought is gradually reduced, the projection of draw-in groove is also released gradually, accordingly, draw-in groove 515 be applied to absorb carrier 522 pressure also progressively reduce.Lose the carrier after pressure 522 because of the elasticity of self, progressively recover original size.Reinstatement along with carrier 522, draw-in groove 515 is oppressed to be moved to the outside of the first cavity 512, when draw-in groove move to the bending part of its card article 5152 arrive the sidewall 5122 of the first cavity outer time, card article 5152 recovers elastic, eject from draw-in groove 515 and its bending part is engaged on sidewall 5122, draw-in groove 515 is fixed, as shown in figure 11.Now, the liquid level of the mixed liquor in the second cavity 511 is higher, bottom more than the first cavity 512, and carrier 522 is because of restorable reason, having very strong absorbability, therefore by the open sidewall 5121 of the first cavity and the groove 5153 of draw-in groove flows into the first cavity 512 to the fluid-mixing in the second cavity 511 and loaded body 522 absorbs.Mixed liquor after loaded body 522 absorption mixes fully in carrier 522.
Again rotate collection well 520, it is made to arrive the 4th position 804 from the 3rd present position 803, now, it is the same that the draw-in groove 515 of the first cavity 512 is turned to the second position 802 with sample collection rod 520 before by primary importance 801, finally all move in the first cavity 512, extruding carrier 522, makes the mixed liquor on carrier 522 all discharge and is flowed in the second cavity 511.
In some more specifically mode, it is also possible to allow and assembly of the invention is connected in a test chamber 530, detect.Specifically, by projection 533 place at the sample reception zone position place of corresponding for the pad 518 of the bottom of the second cavity 511 test chamber 530.This projection 533 is inner hollow, and the part of hollow is connected with the sample region of acceptance of test chamber 530 close beta element.On the top of protruding 533, having an aperture, this aperture connects with the hollow space of projection 533.Projection 533 in test chamber is poked the pad 518 of the second cavity and is entered in the second cavity 511, in second cavity 511, well-mixed mixed liquor is flowed on the testing element of test chamber 530 by the aperture of protruding 533, testing element complete corresponding detection.
Claims (13)
1. the device collecting fluid sample, including the first cavity and the second cavity, wherein, first cavity is positioned at the second cavity, and the first cavity and the second cavity fluid are connected, described first cavity and the second cavity relatively rotate and make fluid flow between the first cavity and the second cavity, and the first cavity has primary importance and the second position in the second cavity.
2. device according to claim 1, it is characterised in that described first cavity also includes two symmetrical moving elements, in second cavity, the wire length of any two points is a and b, wherein a is more than b, and the distance sum between length and the moving element of moving element itself is c, and wherein c is more than b.
3. device according to claim 1, it is characterised in that the first cavity is connected by sidewall and second cavity of opening；Described first cavity also includes two symmetrical moving elements, and when the first cavity is turned to the second position by primary importance, the first cavity drive moving element enters the first cavity by opening and causes the space of described first cavity to diminish.
4. the device according to Claims 2 or 3, it is characterised in that include the projection coordinated with the second cavity on moving element, when the first cavity and the second cavity rotate, the inwall of the second cavity promotes projection to make moving element move to the first inside cavity.
5. the device according to Claims 2 or 3, it is characterised in that moving element includes allowing fluid flow into the passage of the second cavity from the first cavity.
6. according to the device one of claim 1-5 Suo Shu, it is characterised in that can be also used for housing in the first cavity and collect the carrier that can be compressed having fluid sample, the carrier that compression is described when moving element enters the first cavity time.
7. device according to claim 6, it is characterised in that this device also includes sample collection rod, collects rod and comprises the described carrier that can be compressed.
8. device according to claim 7, it is characterised in that described sample collection rod coordinates with the first cavity, drives the first cavity to rotate in the second cavity.
9. device according to claim 1, it is characterised in that this device also includes the seal equipped with buffer solution, this seal is arranged in the first cavity, punctures described seal when moving element enters the first cavity time.
10. device according to claim 1, it is characterised in that this device also includes fixing the 3rd cavity being connected with the first cavity, and this seal, between the second cavity and the 3rd cavity, includes the puncturing elements of projection at the 3rd chamber outer wall.
11. device according to claim 10, it is characterised in that when the first cavity is turned to the second position by primary importance, puncturing elements punctures the seal being positioned between the second cavity and the 3rd cavity.
12. device according to claim 1, it is characterised in that this device also includes the test chamber for holding testing element, this test chamber and the second cavity configured in fluid communication.
13. the device according to Claims 2 or 3, it is characterized in that, time moving element is in primary importance, moving element is on the line length a of any two points in the second cavity, time moving element is in the second position, moving element is in the second cavity on the long length b of the line of any two points.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610101022.6A CN105748108B (en) | 2012-10-24 | 2012-10-24 | A kind of device |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210409899.3A CN103776660B (en) | 2012-10-24 | 2012-10-24 | A kind of device |
| CN201610101022.6A CN105748108B (en) | 2012-10-24 | 2012-10-24 | A kind of device |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210409899.3A Division CN103776660B (en) | 2012-10-24 | 2012-10-24 | A kind of device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105748108A true CN105748108A (en) | 2016-07-13 |
| CN105748108B CN105748108B (en) | 2019-04-05 |
Family
ID=56331114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610101022.6A Active CN105748108B (en) | 2012-10-24 | 2012-10-24 | A kind of device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105748108B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021227380A1 (en) * | 2020-05-11 | 2021-11-18 | 广州达安基因股份有限公司 | Preservation tube for sampling swab |
| WO2023029054A1 (en) * | 2021-09-06 | 2023-03-09 | 皮乐迪有限公司 | Acquisition assembly |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1823273A (en) * | 2003-07-11 | 2006-08-23 | 香港澳维有限公司 | Compact analyte testing cassette with true positive and negative analyte controls |
| CN101498655A (en) * | 2005-10-25 | 2009-08-05 | 艾康生物技术(杭州)有限公司 | Detecting instrument for liquid sample |
| CN101961520A (en) * | 2009-07-21 | 2011-02-02 | 崇仁(厦门)医疗器械有限公司 | Water collecting bottle |
| WO2011106384A1 (en) * | 2010-02-23 | 2011-09-01 | Genturadx, Inc. | Apparatus and methods for integrated sample preparation, reaction and detection |
-
2012
- 2012-10-24 CN CN201610101022.6A patent/CN105748108B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1823273A (en) * | 2003-07-11 | 2006-08-23 | 香港澳维有限公司 | Compact analyte testing cassette with true positive and negative analyte controls |
| CN101498655A (en) * | 2005-10-25 | 2009-08-05 | 艾康生物技术(杭州)有限公司 | Detecting instrument for liquid sample |
| CN101961520A (en) * | 2009-07-21 | 2011-02-02 | 崇仁(厦门)医疗器械有限公司 | Water collecting bottle |
| WO2011106384A1 (en) * | 2010-02-23 | 2011-09-01 | Genturadx, Inc. | Apparatus and methods for integrated sample preparation, reaction and detection |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021227380A1 (en) * | 2020-05-11 | 2021-11-18 | 广州达安基因股份有限公司 | Preservation tube for sampling swab |
| US11839877B2 (en) | 2020-05-11 | 2023-12-12 | Da An Gene Co., Ltd. | Preservation tube for sampling swab |
| WO2023029054A1 (en) * | 2021-09-06 | 2023-03-09 | 皮乐迪有限公司 | Acquisition assembly |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105748108B (en) | 2019-04-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104956197B (en) | A kind of device collected and detect analyte in liquid fluid sample | |
| CN203083845U (en) | Collecting device | |
| US20230204468A1 (en) | Sample collection and detection device and method | |
| CN110366682B (en) | Fecal sampling and occult blood detection integrated device | |
| CN107238697B (en) | A method of it collects and detects sample | |
| CN104634611B (en) | A method of the device of quantitative shunting is carried out to liquid sample and uses the device | |
| AU2021200665B2 (en) | Device and method for collecting and detecting samples | |
| JP2001503858A (en) | Liquid sample collection method for analytical testing | |
| CN105829861A (en) | A device and method for using the device | |
| CN102379724A (en) | Device for collecting fluid samples | |
| US9404910B2 (en) | Body fluid testing apparatus with testing and storing functions | |
| CN102466581B (en) | A kind of device | |
| CN202928839U (en) | Sample collection device | |
| CN107036848A (en) | The device that a kind of sample is collected and detected | |
| CN105748108A (en) | Device | |
| CN208140386U (en) | Fecal sample integral collecting device | |
| CN103575575A (en) | Device | |
| CN202119661U (en) | Device and box for treating samples | |
| CN206847996U (en) | Sample is collected and the device of detection | |
| CN202141619U (en) | Sample processing device and box employing same | |
| CN210401424U (en) | Sample collection member | |
| CN206847995U (en) | Applicator | |
| CN217543122U (en) | Sample collecting bottle | |
| CN210401425U (en) | Sample collecting and detecting device | |
| CN212514605U (en) | Detection device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |