CN105745226B - 包含抗-磷脂酶d4抗体的药物 - Google Patents

包含抗-磷脂酶d4抗体的药物 Download PDF

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Publication number
CN105745226B
CN105745226B CN201480047721.6A CN201480047721A CN105745226B CN 105745226 B CN105745226 B CN 105745226B CN 201480047721 A CN201480047721 A CN 201480047721A CN 105745226 B CN105745226 B CN 105745226B
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seq
antibody
variable region
heavy chain
light chain
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Chinese (zh)
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CN105745226A (zh
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山崎智英
远藤真由木
石田晃司
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SBI Biotech Co Ltd
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SBI Biotech Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201480047721.6A 2013-07-30 2014-07-30 包含抗-磷脂酶d4抗体的药物 Active CN105745226B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013-158258 2013-07-30
JP2013158258 2013-07-30
PCT/JP2014/070661 WO2015016386A1 (en) 2013-07-30 2014-07-30 Medicament comprising anti-phospholipase d4 antibody

Publications (2)

Publication Number Publication Date
CN105745226A CN105745226A (zh) 2016-07-06
CN105745226B true CN105745226B (zh) 2020-03-06

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CN201480047721.6A Active CN105745226B (zh) 2013-07-30 2014-07-30 包含抗-磷脂酶d4抗体的药物

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Country Link
US (2) US20160168266A1 (https=)
EP (1) EP3027656B1 (https=)
JP (3) JP6431523B2 (https=)
KR (1) KR102367760B1 (https=)
CN (1) CN105745226B (https=)
AU (1) AU2014297217B2 (https=)
BR (1) BR112016002001B1 (https=)
CA (1) CA2919736C (https=)
DK (1) DK3027656T3 (https=)
ES (1) ES2736324T3 (https=)
HU (1) HUE044469T2 (https=)
MX (1) MX381725B (https=)
PL (1) PL3027656T3 (https=)
RU (1) RU2709741C2 (https=)
SG (2) SG10201800592SA (https=)
TR (1) TR201910330T4 (https=)
WO (1) WO2015016386A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20210044A1 (ar) 2010-12-30 2017-06-16 Takeda Pharmaceuticals Co الأجسام المضادة لـ cd38
EP3431504B1 (en) * 2012-01-31 2021-03-24 SBI Biotech Co., Ltd. Anti-phospholipase d4 antibody
MX381725B (es) * 2013-07-30 2025-03-13 Sbi Biotech Co Ltd Medicamento que comprende anticuerpo anti-fosfolipasa d4.
MA45674A (fr) 2016-07-15 2019-05-22 Takeda Pharmaceuticals Co Méthodes et matériaux permettant d'évaluer une réponse à des traitements de déplétion de plasmoblastes et de plasmocytes
KR20210006321A (ko) 2018-01-12 2021-01-18 다케다 야쿠힌 고교 가부시키가이샤 항-cd38 항체의 피하 투여
JP7140367B2 (ja) * 2018-05-31 2022-09-21 国立大学法人 東京大学 ヒト由来サンプルにおける可溶型ｔｌｒ７の分析

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000011015A1 (en) * 1998-08-24 2000-03-02 Alphagene, Inc. Secreted proteins and polynucleotides encoding them

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD1367C2 (ro) * 1992-11-13 2000-11-30 Idec Pharmaceuticals Corporation Metode de tratament al limfomului celulelor B, anticorpi anti-CD20, hibridom.
US20020146686A1 (en) * 2000-12-07 2002-10-10 Millennium Pharmaceuticals, Inc. Methods and compositions for the diagnosis and treatment of viral disease using 55092
JP2013052781A (ja) 2011-09-05 2013-03-21 Tokai Rika Co Ltd 車両用ミラー装置
EP3431504B1 (en) * 2012-01-31 2021-03-24 SBI Biotech Co., Ltd. Anti-phospholipase d4 antibody
MX381725B (es) * 2013-07-30 2025-03-13 Sbi Biotech Co Ltd Medicamento que comprende anticuerpo anti-fosfolipasa d4.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000011015A1 (en) * 1998-08-24 2000-03-02 Alphagene, Inc. Secreted proteins and polynucleotides encoding them

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Affinity improvement of single antibody VH domains: residues in all three hypervariable regions affect antigen binding;DAVIES J ET AL;《IMMUNOTECHNOLOGY,》;19960901;第2卷(第3期);169-179 *
Phospholipase D Family Member 4, a Transmembrane Glycoprotein with No Phospholipase D Activity, Expression in Spleen and Early Postnatal Microglia;Fumio Yoshikawa ET AL;《PLoS ONE》;20101111;第5卷(第11期);e13932 *
PLD4 ls Involved in Phagocytosis of Microglia: Expression and Localization Changes of PLD4 Are Correlated with Activation State of MicrogIia;Yoshinori Otani ET AL;《PLoS ONE》;20111115;第6卷(第11期);e27544 *

Also Published As

Publication number Publication date
DK3027656T3 (da) 2019-08-05
CN105745226A (zh) 2016-07-06
EP3027656B1 (en) 2019-06-26
RU2016106708A (ru) 2017-09-01
US20210130493A1 (en) 2021-05-06
JP2019214621A (ja) 2019-12-19
JP2016534022A (ja) 2016-11-04
AU2014297217B2 (en) 2020-01-16
MX2016001193A (es) 2016-05-26
SG10201800592SA (en) 2018-03-28
EP3027656A1 (en) 2016-06-08
BR112016002001B1 (pt) 2023-04-25
KR102367760B1 (ko) 2022-02-24
AU2014297217A1 (en) 2016-02-18
RU2016106708A3 (https=) 2018-03-30
SG11201600666SA (en) 2016-02-26
JP6431523B2 (ja) 2018-11-28
ES2736324T3 (es) 2019-12-27
JP6843449B2 (ja) 2021-03-17
WO2015016386A1 (en) 2015-02-05
JP2019014759A (ja) 2019-01-31
CA2919736A1 (en) 2015-02-05
KR20160034934A (ko) 2016-03-30
MX381725B (es) 2025-03-13
RU2709741C2 (ru) 2019-12-19
US20160168266A1 (en) 2016-06-16
HUE044469T2 (hu) 2019-10-28
PL3027656T3 (pl) 2019-10-31
BR112016002001A2 (pt) 2017-08-29
TR201910330T4 (tr) 2019-07-22
CA2919736C (en) 2022-03-22

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