CN105732756B - 一种脂溶性地塞米松衍生物的纯化方法 - Google Patents
一种脂溶性地塞米松衍生物的纯化方法 Download PDFInfo
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- CN105732756B CN105732756B CN201610065324.2A CN201610065324A CN105732756B CN 105732756 B CN105732756 B CN 105732756B CN 201610065324 A CN201610065324 A CN 201610065324A CN 105732756 B CN105732756 B CN 105732756B
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- dexamethasone
- ethyl acetate
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- mixed liquor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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Claims (10)
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CN201610065324.2A CN105732756B (zh) | 2016-01-29 | 2016-01-29 | 一种脂溶性地塞米松衍生物的纯化方法 |
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CN201610065324.2A CN105732756B (zh) | 2016-01-29 | 2016-01-29 | 一种脂溶性地塞米松衍生物的纯化方法 |
Publications (2)
Publication Number | Publication Date |
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CN105732756A CN105732756A (zh) | 2016-07-06 |
CN105732756B true CN105732756B (zh) | 2017-11-03 |
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CN201610065324.2A Active CN105732756B (zh) | 2016-01-29 | 2016-01-29 | 一种脂溶性地塞米松衍生物的纯化方法 |
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CN (1) | CN105732756B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN110041391B (zh) * | 2019-04-01 | 2021-12-07 | 江苏远大仙乐药业有限公司 | 一种地塞米松棕榈酸酯的合成方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4427649A (en) * | 1976-03-19 | 1984-01-24 | Imperial Chemical Industries Limited | Pharmaceutical compositions |
CN101410098A (zh) * | 2006-01-23 | 2009-04-15 | 耶路撒冷希伯来大学伊森姆研究发展公司 | 包括含亲脂性药物的纳米胶囊的微球 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995017309A1 (fr) * | 1993-12-22 | 1995-06-29 | Seiko Epson Corporation | Imprimante de bandes |
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2016
- 2016-01-29 CN CN201610065324.2A patent/CN105732756B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4427649A (en) * | 1976-03-19 | 1984-01-24 | Imperial Chemical Industries Limited | Pharmaceutical compositions |
CN101410098A (zh) * | 2006-01-23 | 2009-04-15 | 耶路撒冷希伯来大学伊森姆研究发展公司 | 包括含亲脂性药物的纳米胶囊的微球 |
Non-Patent Citations (4)
Title |
---|
Liposome-incorporated dexamethasone palmitate:Chemical and physical properties;H. Benameur 等;《International Journal of Pharmaceutics》;19930331;第89卷(第3期);第157-167页 * |
Use of a lipid emulsion as a novel carrier for corticosteroids;Y.MIZUSHIMA 等;《J. Pharm. Pharmacol.》;19810511;第34卷;第49-50页 * |
地塞米松棕榈酸酯的合成;张兰英 等;《山东医药工业》;20010131;第20卷(第1期);第1页 * |
地塞米松棕榈酸酯的合成工艺改进;李春钢 等;《中国城乡企业卫生》;20120228(第1期);第85-86页 * |
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CN105732756A (zh) | 2016-07-06 |
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Effective date of registration: 20210618 Address after: Room 1424, 4 / F, Mudan Chuangye building, 2 Huayuan Road, Haidian District, Beijing Patentee after: Beijing Zhonglian Technology Service Co.,Ltd. Address before: 100048 No. 105 West Third Ring Road North, Beijing, Haidian District Patentee before: Capital Normal University Effective date of registration: 20210618 Address after: 224500 No.53 private enterprise Pioneer Park, Tongyu Town, Binhai County, Yancheng City, Jiangsu Province Patentee after: Binhai Yangma technical service studio Address before: Room 1424, 4 / F, Mudan Chuangye building, 2 Huayuan Road, Haidian District, Beijing Patentee before: Beijing Zhonglian Technology Service Co.,Ltd. |
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Effective date of registration: 20210629 Address after: 110027 No.1-3, No.10 Road, Shenyang Economic and Technological Development Zone, Liaoning Province Patentee after: SHENYANG SUNSHINE PHARMACEUTICAL Co.,Ltd. Address before: 224500 No.53 private enterprise Pioneer Park, Tongyu Town, Binhai County, Yancheng City, Jiangsu Province Patentee before: Binhai Yangma technical service studio |