CN105727179A - Heart calming medicine and preparation method thereof - Google Patents
Heart calming medicine and preparation method thereof Download PDFInfo
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- CN105727179A CN105727179A CN201610139603.9A CN201610139603A CN105727179A CN 105727179 A CN105727179 A CN 105727179A CN 201610139603 A CN201610139603 A CN 201610139603A CN 105727179 A CN105727179 A CN 105727179A
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Abstract
The invention discloses a heart calming medicine and a preparation method thereof.The medicine comprises medicinal materials including Poria Cocos, Semen Armeniacae Amarum, raw Semen Coicis, Flos Inulae, Radix et Rhizoma Rubiae, Flos Carthami, Radix Salviae Miltiorrhizae, Caulis Perillae, Radix Notoginseng, Radix Curcumae, Bulbus Fritillariae Cirrhosae, Fructus Trichosanthis, Radix Glycyrrhizae Preparata, Bulbus Lilii, Arillus Longan, Folium Eriobotryae, Herba Eupatorii Lindleyani, Semen Agriophylli Squarrosi, Fructus Perillae, radix Peucedani, Semen Raphani, Semen Persicae, Ramulus Euonymi, Herba Salviae Chinensis, agilawood and Radix Cynoglossi Amabilis.The heart calming medicine has a major function of treating symptoms including palpitation, chest stuffiness, chest pain, breath shortness and the like caused by coronary insufficiency.The heart calming medicine prepared from the medicinal materials is extensive in source, low in cost, less prone to tolerance, safe, effective and timely in illness condition control, the cure rate is increased, and integral body immunity is improved.
Description
Technical field
The present invention relates to pharmaceutical technology, relate to a kind of medicine with all worries set aside and preparation method, particularly to medicine and the preparation method of a kind of nervous, uncomfortable in chest, chest pain treating that coronary insufficiency causes.
Background technology
The each histoorgan of human body to maintain its normal vital movement, it is necessary to heart ceaselessly beats to ensure that blood is transported.And heart is as the flesh working organ of a pump blood, itself being also required to enough nutrition and the energy, the vascular system of supply cardiotrophin, it is simply that coronary artery and vein, also referred to as coronary circulation.Coronary artery is supplied with the tremulous pulse of heart blood, arises from aortic root, and point two, left and right, row is in heart surface.Under normal circumstances, it is only small to the resistance of blood, less than the 5% of overall coronary resistance, enters the blood vessel of heart wall from epicardial arteries, and a class is outer, the midmyocardium of plexi dispersion domination ventricle wall；One class is that diameter subtracts hardly, and constitutes arciform network with other perforating branches under endocardium, then separates arteriole and blood capillary again vertically under the through endocardium of locular wall (i.e. perforating branches).Clump and perforating branches form abundant capillary network between cardiac muscle fiber, supply myocardial blood.Though coronary artery is little, but blood flow is very big.Accounting for the 5% of cardiac output, this guarantees heart has enough nutrition, maintains it and effectively around the clock beats.If coronary insufficiency blocks suddenly, it is impossible to quickly set up Doppler flow mapping, usually can cause nervous, uncomfortable in chest, chest pain, the disease such as breathe hard, the concurrent coronary heart diseases and angina pectoris of severe patient cocoa, heart infarction, even threat to life.
Simple western medical treatment widely applies chemical synthetic drug, and untoward reaction is more, but such as symptom management, the then life security of entail dangers to patient not in time；Non-drug therapy is then traumatic relatively big, and costly, body recovery is slow.Nervous, uncomfortable in chest, chest pain that Chinese medicine coronary insufficiency causes, the disease such as breathe hard, can make up the deficiency of doctor trained in Western medicine, adopt Chinese crude drug, and medicine source is extensive, price is low, is not likely to produce drug resistance, safely and effectively, timely symptom management, improves cure rate, improves the immunity that body is overall.
Summary of the invention
The technical problem to be solved in the present invention is in that to provide a kind of medicine with all worries set aside, nervous, uncomfortable in chest, the chest pain that cures mainly that coronary insufficiency causes, the disease such as breathe hard.The present invention adopts Chinese crude drug, and medicine source is extensive, and price is low, is not likely to produce drug resistance, safely and effectively, regulates QI and blood, improves blood circulation, timely symptom management, improves cure rate, improves the immunity that body is overall.
In order to realize foregoing invention purpose, the invention provides a kind of medicine with all worries set aside, it is characterized in that, including following raw medicinal material: Poria, Semen Armeniacae Amarum, raw pearl barley, Flos Inulae, Radix Rubiae, Flos Carthami, Radix Salviae Miltiorrhizae, Caulis Perillae, Radix Notoginseng, Radix Curcumae, Bulbus Fritillariae Uninbracteatae, Fructus Trichosanthis, Radix Glycyrrhizae Preparata, Bulbus Lilii, Arillus Longan, Folium Eriobotryae, Herba Eupatorii Lindleyani, east, Fructus Perillae, drought Radix Peucedani, Semen Raphani, Semen Persicae, Ramulus Euonymi, Herba Salviae Chinensis, Lignum Aquilariae Resinatum and JIZHUASHEN.
In described medicine, the ratio of weight and number of each raw medicinal material is: Poria 10-30 part, Semen Armeniacae Amarum 3-20 part, raw pearl barley 10-30 part, Flos Inulae 10-20 part, Radix Rubiae 10-30 part, Flos Carthami 1-20 part, Radix Salviae Miltiorrhizae 10-30 part, Caulis Perillae 10-20 part, Radix Notoginseng 1-10 part, Radix Curcumae 10-20 part, Bulbus Fritillariae Uninbracteatae 10-20 part, Fructus Trichosanthis 1-20 part, Radix Glycyrrhizae Preparata 3-15 part, Bulbus Lilii 11-21 part, Arillus Longan 8-17 part, Folium Eriobotryae 2-19 part, Herba Eupatorii Lindleyani 12-23 part, the sub-4-18 part in east, Fructus Perillae 11-29 part, drought Radix Peucedani 2-19 part, Semen Raphani 7-24 part, Semen Persicae 13-27 part, Ramulus Euonymi 3-14 part, Herba Salviae Chinensis 6-18 part, Lignum Aquilariae Resinatum 10-27 part and JIZHUASHEN 5-19 part.
In described medicine, the ratio of weight and number of each raw medicinal material is: Poria 15-25 part, Semen Armeniacae Amarum 5-17 part, raw pearl barley 16-27 part, Flos Inulae 12-17 part, Radix Rubiae 15-27 part, Flos Carthami 3-16 part, Radix Salviae Miltiorrhizae 14-26 part, Caulis Perillae 13-18 part, Radix Notoginseng 3-8 part, Radix Curcumae 12-17 part, Bulbus Fritillariae Uninbracteatae 13-18 part, Fructus Trichosanthis 4-17 part, Radix Glycyrrhizae Preparata 6-12 part, Bulbus Lilii 14-19 part, Arillus Longan 10-15 part, Folium Eriobotryae 5-14 part, Herba Eupatorii Lindleyani 16-20 part, the sub-6-14 part in east, Fructus Perillae 14-26 part, drought Radix Peucedani 5-15 part, Semen Raphani 10-20 part, Semen Persicae 15-24 part, Ramulus Euonymi 5-11 part, Herba Salviae Chinensis 9-15 part, Lignum Aquilariae Resinatum 14-24 part and JIZHUASHEN 7-16 part.
In described medicine, the ratio of weight and number of each raw medicinal material is: 25 parts of Poria, 5 parts of Semen Armeniacae Amarum, raw pearl barley 23 parts, Flos Inulae 12 parts, 27 parts of Radix Rubiae, 3 parts of Flos Carthami, Radix Salviae Miltiorrhizae 26 parts, Caulis Perillae 15 parts, Radix Notoginseng 3 parts, Radix Curcumae 17 parts, Bulbus Fritillariae Uninbracteatae 18 parts, Fructus Trichosanthis 10 parts, Radix Glycyrrhizae Preparata 6 parts, Bulbus Lilii 15 parts, Arillus Longan 10 parts, Folium Eriobotryae 5 parts, Herba Eupatorii Lindleyani 20 parts, east 14 parts, Fructus Perillae 26 parts, drought Radix Peucedani 8 parts, Semen Raphani 20 parts, 19 parts of Semen Persicae, Ramulus Euonymi 5 parts, Herba Salviae Chinensis 12 parts, Lignum Aquilariae Resinatum 24 parts and JIZHUASHEN 11 parts.
In described medicine, the ratio of weight and number of each raw medicinal material is: 21 parts of Poria, 17 parts of Semen Armeniacae Amarum, raw pearl barley 27 parts, Flos Inulae 15 parts, 20 parts of Radix Rubiae, 16 parts of Flos Carthami, Radix Salviae Miltiorrhizae 23 parts, Caulis Perillae 18 parts, Radix Notoginseng 8 parts, Radix Curcumae 15 parts, Bulbus Fritillariae Uninbracteatae 13 parts, Fructus Trichosanthis 4 parts, Radix Glycyrrhizae Preparata 12 parts, Bulbus Lilii 19 parts, Arillus Longan 15 parts, Folium Eriobotryae 8 parts, Herba Eupatorii Lindleyani 16 parts, east 6 parts, Fructus Perillae 23 parts, drought Radix Peucedani 15 parts, Semen Raphani 10 parts, 15 parts of Semen Persicae, Ramulus Euonymi 11 parts, Herba Salviae Chinensis 15 parts, Lignum Aquilariae Resinatum 19 parts and JIZHUASHEN 7 parts.
In described medicine, the ratio of weight and number of each raw medicinal material is: 15 parts of Poria, 9 parts of Semen Armeniacae Amarum, raw pearl barley 16 parts, Flos Inulae 17 parts, 15 parts of Radix Rubiae, 13 parts of Flos Carthami, Radix Salviae Miltiorrhizae 14 parts, Caulis Perillae 13 parts, Radix Notoginseng 5 parts, Radix Curcumae 12 parts, Bulbus Fritillariae Uninbracteatae 15 parts, Fructus Trichosanthis 17 parts, Radix Glycyrrhizae Preparata 9 parts, Bulbus Lilii 14 parts, Arillus Longan 12 parts, Folium Eriobotryae 14 parts, Herba Eupatorii Lindleyani 18 parts, east 9 parts, Fructus Perillae 14 parts, drought Radix Peucedani 5 parts, Semen Raphani 15 parts, 24 parts of Semen Persicae, Ramulus Euonymi 8 parts, Herba Salviae Chinensis 9 parts, Lignum Aquilariae Resinatum 14 parts and JIZHUASHEN 16 parts.
When the dosage form of described medicine is decoction, its preparation method comprises the following steps:
Step one: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to the dipped medical material upper surface 2-5cm of clear water, soak 3-10 hour；
Step 2: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts 30-50 minute slowly, filter, obtain filtrate a, standby；
Step 3: residue medicinal residues are added clear water again, to the dipped medical material upper surface 2-3cm of clear water, soaks 3-10 hour；
Step 4: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts 25-35 minute slowly, filter, obtain filtrate b, mixed by filtrate a and filtrate b.
When the dosage form of described endo-medicine is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that alcohol volumetric concentration is 85%～95% relative to 4～8 times of mixture, heat to boiling reflux 3～5 hours, filter, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa is the mastic of 1.04～1.10, spray drying, the inlet temperature of spray dryer 160～175 DEG C, leaving air temp 80～85 DEG C, it is ground into powder subsequently, makes dried cream powder；
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.2～0.4 times and 0.1～0.2 times in the dried cream powder obtained, make granule, dries in 40～50 DEG C, it is thus achieved that granule.
Medicine is decocted decoction in use and is taken, and every day 1 dose, decocting is taken at twice；When this Chinese medicine is granule use, an oral 10g, every day 2-3 time.
Nervous, uncomfortable in chest, chest pain that technical scheme provided by the invention has the benefit that medicine of the present invention cures mainly that coronary insufficiency causes, the disease such as breathe hard.The present invention adopts Chinese crude drug, and medicine source is extensive, and price is low, is not likely to produce drug resistance, safely and effectively, regulates QI and blood, improves blood circulation, timely symptom management, improves cure rate, improves the immunity that body is overall.
Detailed description of the invention
The invention provides a kind of medicine with all worries set aside, including following raw medicinal material: Poria, Semen Armeniacae Amarum, raw pearl barley, Flos Inulae, Radix Rubiae, Flos Carthami, Radix Salviae Miltiorrhizae, Caulis Perillae, Radix Notoginseng, Radix Curcumae, Bulbus Fritillariae Uninbracteatae, Fructus Trichosanthis, Radix Glycyrrhizae Preparata, Bulbus Lilii, Arillus Longan, Folium Eriobotryae, Herba Eupatorii Lindleyani, east, Fructus Perillae, drought Radix Peucedani, Semen Raphani, Semen Persicae, Ramulus Euonymi, Herba Salviae Chinensis, Lignum Aquilariae Resinatum and JIZHUASHEN.
The pharmacology of each raw medicinal material is as follows:
Poria: another name Poria, Cortex Sclerotii Poriae, Poria block, Poria, Poria.This product is the dry sclerotia of On Polyporaceae Poria.Excavate more than 7～JIUYUE, remove silt after digging out, bank up after " diaphoresis ", spread out and dry in the air to dry tack free, then " diaphoresis ", after repeatedly scattering and disappearing to now wrinkle, the big portion of internal moisture for several times, dry in the shade, be called " Poria "；Or fresh Poria is pressed different parts cutting, dry in the shade, be called " Cortex Sclerotii Poriae " and " Poria block ".Sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.
Bulbus Lilii: another name Herba Crotalariae sessiliflorae, cone, BULBUS LILII, medicine Bulbus Lilii, family Bulbus Lilii.This product is the dry meat scale leaf of liliaceous plant tiger lily, Bulbus Lilii or Lilium tenuifolium.Autumn excavates, and cleans, strips scale leaf, put in boiling water slightly boiling hot, dry.Sweet, cold.GUIXIN, lung meridian.Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.
Arillus Longan: another name Arillus Longan, Arillus Longan, circle eye.This product is the aril of Sapindaceae Euphoria plant Arillus Longan.Summer, mature fruit of gathering in season in autumn two, dry, remove shell, core, shine and do not stick to dry and comfortable.Sweet, temperature.GUIXIN, spleen channel.Invigorating the heart and spleen, nourishing blood to tranquillize the mind.
Semen Armeniacae Amarum: another name almond core, Fructus Pruni, wood is begun, Semen Armeniacae Amarum, Prunus mume var.bungo Makino core.Dry seed for bitter in the mouth such as rosaceous plant Fructus Pruni or Prunus armeniaca L.var.ansu Maxim..Pluck during fruit maturation in summer, remove sarcocarp and nucleocapsid, take kernel, dry.Put shady and cool dry place, Anti-moth-eating.Hardship, temperature.Enter lung, large intestine channel.Expelling phlegm for arresting cough, relievings asthma, intestine moistening.
Folium Eriobotryae: call wide rake leaf, Ba Ye.The leaf of rosaceous plant Folium Eriobotryae.Bitter in the mouth, cold nature.Return lung meridian, stomach warp.Clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.
Herba Eupatorii Lindleyani: another name point Herba Eupatorii, Herba Eupatorii, hoary hair mother-in-law.The dry aerial parts of feverfew Eupatorium lindleyanum.Property is put down, bitter in the mouth.Return lung meridian.Expectorant cough suppressant and anti-asthmatic.
Raw pearl barley: another name Semen Coicis, Semen Coicis, NLIUGU, for the kernel of grass Semen Coicis.Cool in nature, sweet in the mouth, light, enter spleen, lung, kidney channel.Diuretic, spleen invigorating, eliminating impediment, clearing away heat and discharging pus.
East: call husky fluffy rice, husky rice, step on relevant, step on foxtail millet, lucky thorn.For the husky fluffy seed of chenopod.Sweet；Property is put down.Return lung；Spleen；Stomach warp.Strengthening the spleen to promote digestion；Deliver antipyretic；Diuretic.Main eating accumulation；Dysphagia and regurgitation；Cat fever；Nephritis.1. supplement to the Herbal: QI invigorating is made light of one's life by commiting suicide, hard muscles and bones.2. " a little free time lattice thing of Kangxu is compiled ": property warms up, strengthening the spleen stomach, it is easy to digestion, does not tell well person, and polyphagia is useful.3. " property of medicine is examined ": heat clearing away pathogenic wind expelling.4. " detailed outline is picked up any lost article from the road ": tonneau large intestine, disappear dyspepsia, controls dysphagia and regurgitation.
Flos Inulae: another name Herba Inulae, June chrysanthemum, drum flower, drip drip Hemerocallis citrina Baroni golden, little son, money flower, donkey dish.This product is the dry capitulum of feverfew Flos Inulae or Inula britannica.Summer, season in autumn two, the flowers are in blossom gathers when putting, and removes impurity, dries in the shade or dry.Hardship, pungent, salty, tepor.Return lung, spleen, stomach, large intestine channel.Sending down the abnormal ascending QI, expectorant, row water, preventing or arresting vomiting.
Fructus Perillae: another name Fructus Perillae, FRUCTUS PERILLAE.This product is the dry mature fruit of labiate Folium Perillae.Gather during fruit maturation in autumn, remove impurity, dry.Pungent, temperature.Return lung meridian.Sending down the abnormal ascending QI expectorant, relievings asthma, intestine moistening.
Drought Radix Peucedani: Radix Peucedani, red Radix Peucedani, plumage split Rhizoma Ligustici, Yunnan Radix Peucedani.Root for samphire plumage bud Rhizoma Ligustici.Bitter in the mouth；Pungent；Cool in nature.Dissipate wind heat clearing away；Therapeutic method to keep the adverse QI flowing downwards expectorant；Promoting blood flow to regulate menstruation.
Semen Raphani: Semen Raphani.This product is the dry mature seed of crucifer Radix Raphani.Tap plant during fruit maturation in summer, dry, rub seed, remove impurity, then dry.Pungent, sweet, flat.Return lung, spleen, stomach warp.Help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.
Radix Rubiae: another name Galium spurium L., uproot plants after their edible portions have been harvested, HUOXUECAO, red Radix Rubiae, carriage, extension draw bean, red line grass, Radix seu Caulis Schisandrae Sinensis, Herba Chenopodii Hybridi.This product is the dry root and rhizome of Maguireothamnus speciosus Radix Rubiae.Spring, season in autumn two excavate, and remove silt, dry.Hardship, cold.Return Liver Channel.Removing heat from blood, hemostasis, blood stasis dispelling, stimulates the menstrual flow.
Flos Carthami: another name Flos Carthami.This product is the dried floral of feverfew Flos Carthami.Summer flower by xanthochromia red time pluck and take tubular flower, notes the ovary not hindering base portion, removes impurity, drying in the shade or low baking temperature drying, now matter is softer, the red the best of color depth.(gather flower time, should dew in morning is not dry as early as possible, the sharp thorn of bract carries out time softer, but also unsuitable too early.) pungent, temperature.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.
Radix Salviae Miltiorrhizae: another name Arisaema balansae Engl., Radix Campylotropis Hirtella (Herba Myrsines Africanae), Herba Wedeliae Wallichii root, blood mountain root, RADIX SALVIAE MILTIORRHIZAE, Radix Salviae Miltiorrhizae.This product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.Spring, season in autumn two excavate, and remove silt, dry.Hardship, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.
Caulis Perillae: another name Caulis Perillae.This product is the dry stem of labiate Folium Perillae.Autumn taps after fruit maturation, removes impurity, dries, or take advantage of fresh slices, dry.Pungent, temperature.Return lung, spleen channel.Regulating the flow of QI to ease the stomach, pain relieving, antiabortive.
Herba Salviae Chinensis: another name Herba Salviae Chinensis, Herba Salviae Chinensis, red below the moon.Herb for labiate China rat-tail.Gather during fall flowering, dry.Property flat, bitter in the mouth, pungent.Heat-clearing and toxic substances removing, blood circulation promoting regulates qi pain relieving.
Lignum Aquilariae Resinatum: another name Lignum Aquilariae Resinatum, Aquilaria sinensis (Lour.) Spreng., Nv Erxiang.Isolated From Thymelaeaceae Species Lignum Aquilariae Resinatum contains the timber of resin.Acrid in the mouth, hardship, slightly warm in nature.Return kidney channel, spleen channel, stomach warp.Promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma.
Radix Notoginseng: product are the dry root of panax araliaceae plant.Autumn excavates before the flowers are in blossom, cleans, separately main root, supporting root and stem foot, dry.Supporting root is practised and is claimed " rib ", and stem foot is practised and claimed " clip ".Hardship sweet, micro-, temperature.Return liver, stomach warp.Dissipating blood stasis stops blooding, subduing swelling and relieving pain.
Semen Persicae: another name Radix Fici Hirtae core, almond core, big Semen Persicae.The mature seed of rosaceous plant Fructus Persicae.Property flat, bitter in the mouth, sweet.GUIXIN warp, Liver Channel, large intestine channel.Activating blood circulation and dissipating phlegm, loosening bowel to relieve constipation.
Ramulus Euonymi: call four ribs arrow excellent, terrible, winged euonymus.The band wing twig of Celastraceae plant winged euonymus or branch wing.Cold in nature, bitter in the mouth.Return Liver Channel, spleen channel.Promoting the circulation of blood is stimulated the menstrual flow, eliminating stasis to stop pain.
Radix Curcumae: another name radix curcumae, white silk Radix Curcumae.This product is the dried root of zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary or Rhizoma Curcumae.The above two practise title " RADIX CURCUMAE " and " Radix Curcuma " respectively, and all the other are practised by character difference and claim " osmanthus Radix Curcumae " or " green filament Radix Curcumae ".Winter, stem and leaf was excavated after withering, and removes silt and radicula, steams or boil to the saturating heart, dry.Pungent, bitter, cold.Return liver, the heart, lung meridian.Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.
Bulbus Fritillariae Uninbracteatae: another name Bulbus Fritillariae Cirrhosae, Bulbus Fritillariae Cirrhosae.This product is the dry bulb of liliaceous plant Bulbus Fritillariae Cirrhosae, Fritillaria unibracteata, Gansu Bulbus Fritillariae Uninbracteatae or Bulbus Fritillariae cirrhosae.Former three practises title " pine shellfish " and " blue or green shellfish " respectively by character difference, and the latter practises title " lubei ".Excavate when summer, Qiu Erji or snow melting, remove fibrous root, rough bark and silt, dry or cold drying.Bitter, sweet, it is slightly cold.Return lung, heart channel.Clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.
Fructus Trichosanthis: this product is the dry mature fruit of cucurbitaceous plant Fructus Trichosanthis or trichosanthes rosthornii Harms.During fruit maturation in autumn, even carpopodium is cut, and puts ventilation and dries in the shade.Hardship sweet, micro-, cold.Return lung, stomach, large intestine channel.Clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturize laxation.
Radix Glycyrrhizae Preparata: this product is the Preparation process product of Radix Glycyrrhizae.Sweet, flat.GUIXIN, lung, spleen, stomach warp.Spleen reinforcing stomach function regulating, Yiqi and vein recovery.
JIZHUASHEN: the wild Leptoradix Ginseng of another name.Root and rhizome for the blunt leaf Streptopus simplex D. Don of liliaceous plant.Sweet；Temperature.Spleen reinforcing stomach function regulating；Analgesia.
Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
The decoction of embodiment 1 present invention
Take Poria 25g, Semen Armeniacae Amarum 5g, raw pearl barley 23g, Flos Inulae 12g, Radix Rubiae 27g, Flos Carthami 3g, Radix Salviae Miltiorrhizae 26g, Caulis Perillae 15g, Radix Notoginseng 3g, Radix Curcumae 17g, Bulbus Fritillariae Uninbracteatae 18g, Fructus Trichosanthis 10g, Radix Glycyrrhizae Preparata 6g, Bulbus Lilii 15g, Arillus Longan 10g, Folium Eriobotryae 5g, Herba Eupatorii Lindleyani 20g, eastern sub-14g, Fructus Perillae 26g, drought Radix Peucedani 8g, Semen Raphani 20g, Semen Persicae 19g, Ramulus Euonymi 5g, Herba Salviae Chinensis 12g, Lignum Aquilariae Resinatum 24g and JIZHUASHEN 11g.
Its preparation method comprises the following steps:
Step one: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to the dipped medical material upper surface 5cm of clear water, soak 6 hours；
Step 2: be placed on fire by purple casserole, after intense fire boils, using the slow fire pan-fried 50 minutes dosage to medicinal liquid slowly instead is 200ml, filters, obtains filtrate a, standby；
Step 3: residue medicinal residues are added clear water again, to the dipped medical material upper surface 3cm of clear water, soaks 6 hours；
Step 4: be placed on fire by purple casserole, after intense fire boils, using the slow fire pan-fried 30 minutes dosage to medicinal liquid slowly instead is 300ml, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
The granule of embodiment 2 present invention
Take Poria 21g, Semen Armeniacae Amarum 17g, raw pearl barley 27g, Flos Inulae 15g, Radix Rubiae 20g, Flos Carthami 16g, Radix Salviae Miltiorrhizae 23g, Caulis Perillae 18g, Radix Notoginseng 8g, Radix Curcumae 15g, Bulbus Fritillariae Uninbracteatae 13g, Fructus Trichosanthis 4g, Radix Glycyrrhizae Preparata 12g, Bulbus Lilii 19g, Arillus Longan 15g, Folium Eriobotryae 8g, Herba Eupatorii Lindleyani 16g, eastern sub-6g, Fructus Perillae 23g, drought Radix Peucedani 15g, Semen Raphani 10g, Semen Persicae 15g, Ramulus Euonymi 11g, Herba Salviae Chinensis 15g, Lignum Aquilariae Resinatum 19g and JIZHUASHEN 7g.
Its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that alcohol volumetric concentration is 95% relative to 5 times of mixture, heat to boiling reflux 4 hours, filter, adopt percolation with the speed slowly percolation of 2ml per minute, collect percolate, being evaporated to relative density when 60 DEG C subsequently under vacuum 0.09Mpa is the mastic of 1.10, spray drying, the inlet temperature of spray dryer 175 DEG C, leaving air temp 85 DEG C, it is ground into powder subsequently, makes dried cream powder；
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.4 times and 0.2 times in the dried cream powder obtained, make granule, dries in 50 DEG C, it is thus achieved that granule.
The granule of embodiment 3 present invention
Take Poria 15g, Semen Armeniacae Amarum 9g, raw pearl barley 16g, Flos Inulae 17g, Radix Rubiae 15g, Flos Carthami 13g, Radix Salviae Miltiorrhizae 14g, Caulis Perillae 13g, Radix Notoginseng 5g, Radix Curcumae 12g, Bulbus Fritillariae Uninbracteatae 15g, Fructus Trichosanthis 17g, Radix Glycyrrhizae Preparata 9g, Bulbus Lilii 14g, Arillus Longan 12g, Folium Eriobotryae 14g, Herba Eupatorii Lindleyani 18g, eastern sub-9g, Fructus Perillae 14g, drought Radix Peucedani 5g, Semen Raphani 15g, Semen Persicae 24g, Ramulus Euonymi 8g, Herba Salviae Chinensis 9g, Lignum Aquilariae Resinatum 14g and JIZHUASHEN 16g.
Its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that alcohol volumetric concentration is 90% relative to 6 times of mixture, heat to boiling reflux 5 hours, filter, adopt percolation with the speed slowly percolation of 1ml per minute, collect percolate, being evaporated to relative density when 50 DEG C subsequently under vacuum 0.06Mpa is the mastic of 1.04, spray drying, the inlet temperature of spray dryer 160 DEG C, leaving air temp 80 DEG C, it is ground into powder subsequently, makes dried cream powder；
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.2 times and 0.2 times in the dried cream powder obtained, make granule, dries in 40 DEG C, it is thus achieved that granule.
Toxicity test:
Acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 17～24g, carries out acute toxicity test.Mice is randomly divided into two groups, often group 20, i.e. matched group and administration group, fasting 12 hours before experiment；Decoction prepared by embodiments of the invention 1, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, within one day, is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Test result indicate that: compare with matched group, after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Decoction LD50 > 28.7 crude drugs/the kg of the Mouse oral gavage present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.The Chinese medicine clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: 745 times that the dosis tolerata of the Chinese medicine of mice (average weight with 21g) the oral administration gavage present invention is quantity.Therefore the Chinese medicine acute toxicity of the present invention is low, clinical drug safety.
Long term toxicity test: by the granule of the embodiment of the present invention 2 to mice by 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 4 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by Chinese medicine preparation of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety.
Long term toxicity test: by the granule of the embodiment of the present invention 3 to mice by 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 4 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by Chinese medicine preparation of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety.
Clinical data:
Select nervous, uncomfortable in chest, the chest pain that certain institute causes, inpatient 130 example breathed hard due to coronary insufficiency.Wherein male 53 example, women 77 example；32 examples of one full year of life at age 40～50,57 examples of 51～60 one full year of life, 21 examples of 61～70 one full year of life, 20 more than 70 one full year of life examples.
Clinical manifestation:
Cardiopalmus, uncomfortable in chest, breathe hard, one of angina pectoris and ECG alteration item or several, all can except acute myocardial infarction, unstable angina pectoris, severe arrhythmia, serious respiratory system disease, hepatic and renal function injure, electrolyte serious diseases, type 2 diabetes mellitus, and cardiac function is all at II～III grade.
Divide following treatment group, four groups of ages, sex no significant differences.
Decoction treatment group: 34 people, male 15 people, female 19 people.
Granules in Treating group 1:31 people, male 14 people, female 17 people.
Granules in Treating group 2:35 people, male 13 people, female 22 people.
Western medicine group: 30 people, male 11 people, female 19 people.
Therapeutic Method:
Decoction treatment group: taking the decoction of the embodiment of the present invention 1, every day 1 dose, decocting is taken at twice, 1 month is 1 course for the treatment of；
Granules in Treating group 1: take the granule of the embodiment of the present invention 2, an oral 10g, every day 2-3 time, 1 month is 1 course for the treatment of；
Granules in Treating group 2: take the granule of the embodiment of the present invention 3, an oral 10g, every day 2-3 time, 1 month is 1 course for the treatment of；
Western medicine group: traditional oral Bayaspirin Enteric-coated 0.1g, every day 1 time, simvastatin 20mg, every night once.
All treat a course for the treatment of for four groups.
Observation index
Inspection blood, urine, stool routine examination is carried respectively before and after treatment, TC, TG, hepatic and renal function, coagulation function analytical review, before and after treatment and treatment respectively do 1 resting electrocardiogram and compare mid-term, observe uncomfortable in chest, cardiopalmus, breathe hard, angina pectoris attacks number of times and degree, persistent period, the untoward reaction of the rhythm of the heart, changes in heart rate and treatment.
Efficacy assessment standard:
Formulate with reference to angina pectoris and ECG curative effect evaluation criteria:
1, curative effect to treat angina pectoris evaluation criteria
Effective: angina pectoris symptom reduces by 2 grades respectively, it was that I grade, II grade person's angina pectoris disappears substantially originally；
Take a turn for the better: angina pectoris symptom reduces by 1 grade；
Invalid: angina pectoris symptom is without change or has minimizing, but not up to improving degree.
2, uncomfortable in chest, cardiopalmus, symptom of breathing hard improve criterion of therapeutical effect
Effective: uncomfortable in chest, cardiopalmus, breathe hard 7 days in disappear；
Take a turn for the better: uncomfortable in chest, cardiopalmus, breathing hard 8-14 days disappears or take a turn for the better；
Invalid: within more than 15 days, to have no improvement.
3, ECG curative effect standard
Effective: electrocardiogram recovers normal, ST-T recovers normal.
Take a turn for the better: more than reduction in ST segment depression 0.05mV after treatment, but normal, shoal (reaching more than 50%) at the negative T wave that mainly leads, or T ripple is transferred to uprightly by smooth；
Invalid: before and after treatment, ST section, T section are without change.
Effectively add improvement for effective.
Therapeutic outcome:
Referring to table 1, table 2, from table 1, table 2 it can be seen that nervous, uncomfortable in chest, chest pain, the cardiopalmus that adopt that the Drug therapy coronary insufficiency of the present invention causes patient, the disease such as breathe hard, relative to, in western medicine effect, having and be markedly improved.
1 four groups of table is nervous, chest pain, uncomfortable in chest, cardiopalmus, clinical symptoms of breathing hard comparitive study example (%)
| Group | Number of cases | Effective | Take a turn for the better | Invalid | Effective percentage | Inefficiency |
| Decoction treatment group | 34 | 30 | 4 | 0 | 100% | 0% |
| Granules in Treating group 1 | 31 | 28 | 3 | 0 | 100% | 0% |
| Granules in Treating group 2 | 35 | 32 | 3 | 0 | 100% | 0% |
| Western medicine group | 30 | 15 | 8 | 7 | 76.7% | 23.3% |
2 four groups of ECG curative effect comparative examples (%) of table
| Group | Number of cases | Effective | Take a turn for the better | Invalid | Effective percentage | Inefficiency |
| Decoction treatment group | 34 | 32 | 2 | 0 | 100% | 0% |
| Granules in Treating group 1 | 31 | 28 | 3 | 0 | 100% | 0% |
| Granules in Treating group 2 | 35 | 31 | 4 | 0 | 100% | 0% |
| Western medicine group | 30 | 10 | 11 | 9 | 70% | 30% |
According to the clinical statistics in above table it can be seen that Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety is high, the advantage that has no side effect.According to nervous, chest pain, uncomfortable in chest, cardiopalmus, treatment data of breathing hard, 34 examples that are simultaneously that decoction treatment group is effective and that take a turn for the better, effective 31 examples with improvement of granule group treatment group 1, effective 35 examples with improvement of granule group treatment group 2, and western medicine group is effective and the 23 example follow-up of patients 1 year that takes a turn for the better, result is added up:
The effective 34 example patients with improvement of decoction treatment group, effective 30 example patients are without recurrence, and 4 example patients of improvement are without recurrence, and relapse rate is 0%；
The effective 31 example patients with improvement of granule group treatment group 1,28 effective example patients are without recurrence, and 3 example patients of improvement are without recurrence, and relapse rate is 0%；
The effective 35 example patients with improvement of granule group treatment group 2,32 effective example patients are without recurrence, and 3 example patients of improvement are without recurrence, and relapse rate is 0%；
The effective 23 example patients with improvement of western medicine group, 15 effective example patients, without recurrence, recur 5 examples in 8 example patients of improvement, and relapse rate is 21.7%.
Model case: Lee, man, 45 years old, within continuous three months, causeless nervous, uncomfortable in chest, chest pain occurs, breathes hard, it is coronary insufficiency after diagnosing, with the decoction of the embodiment of the present invention 1, every day 1 dose, decocting is taken at twice, after treating 3 days, uncomfortable in chest, cardiopalmus, disappearance of breathing hard, after treating 15 days, symptom is completely eliminated, and visits 2 years without recurrence.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.
Claims (8)
1. medicine one kind with all worries set aside, it is characterized in that, including following raw medicinal material: Poria, Semen Armeniacae Amarum, raw pearl barley, Flos Inulae, Radix Rubiae, Flos Carthami, Radix Salviae Miltiorrhizae, Caulis Perillae, Radix Notoginseng, Radix Curcumae, Bulbus Fritillariae Uninbracteatae, Fructus Trichosanthis, Radix Glycyrrhizae Preparata, Bulbus Lilii, Arillus Longan, Folium Eriobotryae, Herba Eupatorii Lindleyani, east, Fructus Perillae, drought Radix Peucedani, Semen Raphani, Semen Persicae, Ramulus Euonymi, Herba Salviae Chinensis, Lignum Aquilariae Resinatum and JIZHUASHEN.
null2. medicine according to claim 1，It is characterized in that，In described medicine, the ratio of weight and number of each raw medicinal material is: Poria 10-30 part、Semen Armeniacae Amarum 3-20 part、Raw pearl barley 10-30 part、Flos Inulae 10-20 part、Radix Rubiae 10-30 part、Flos Carthami 1-20 part、Radix Salviae Miltiorrhizae 10-30 part、Caulis Perillae 10-20 part、Radix Notoginseng 1-10 part、Radix Curcumae 10-20 part、Bulbus Fritillariae Uninbracteatae 10-20 part、Fructus Trichosanthis 1-20 part、Radix Glycyrrhizae Preparata 3-15 part、Bulbus Lilii 11-21 part、Arillus Longan 8-17 part、Folium Eriobotryae 2-19 part、Herba Eupatorii Lindleyani 12-23 part、The sub-4-18 part in east、Fructus Perillae 11-29 part、Drought Radix Peucedani 2-19 part、Semen Raphani 7-24 part、Semen Persicae 13-27 part、Ramulus Euonymi 3-14 part、Herba Salviae Chinensis 6-18 part、Lignum Aquilariae Resinatum 10-27 part and JIZHUASHEN 5-19 part.
null3. medicine according to claim 1 and 2，It is characterized in that，In described medicine, the ratio of weight and number of each raw medicinal material is: Poria 15-25 part、Semen Armeniacae Amarum 5-17 part、Raw pearl barley 16-27 part、Flos Inulae 12-17 part、Radix Rubiae 15-27 part、Flos Carthami 3-16 part、Radix Salviae Miltiorrhizae 14-26 part、Caulis Perillae 13-18 part、Radix Notoginseng 3-8 part、Radix Curcumae 12-17 part、Bulbus Fritillariae Uninbracteatae 13-18 part、Fructus Trichosanthis 4-17 part、Radix Glycyrrhizae Preparata 6-12 part、Bulbus Lilii 14-19 part、Arillus Longan 10-15 part、Folium Eriobotryae 5-14 part、Herba Eupatorii Lindleyani 16-20 part、The sub-6-14 part in east、Fructus Perillae 14-26 part、Drought Radix Peucedani 5-15 part、Semen Raphani 10-20 part、Semen Persicae 15-24 part、Ramulus Euonymi 5-11 part、Herba Salviae Chinensis 9-15 part、Lignum Aquilariae Resinatum 14-24 part and JIZHUASHEN 7-16 part.
4. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: 25 parts of Poria, 5 parts of Semen Armeniacae Amarum, raw pearl barley 23 parts, Flos Inulae 12 parts, 27 parts of Radix Rubiae, 3 parts of Flos Carthami, Radix Salviae Miltiorrhizae 26 parts, Caulis Perillae 15 parts, Radix Notoginseng 3 parts, Radix Curcumae 17 parts, Bulbus Fritillariae Uninbracteatae 18 parts, Fructus Trichosanthis 10 parts, Radix Glycyrrhizae Preparata 6 parts, Bulbus Lilii 15 parts, Arillus Longan 10 parts, Folium Eriobotryae 5 parts, Herba Eupatorii Lindleyani 20 parts, east 14 parts, Fructus Perillae 26 parts, drought Radix Peucedani 8 parts, Semen Raphani 20 parts, 19 parts of Semen Persicae, Ramulus Euonymi 5 parts, Herba Salviae Chinensis 12 parts, Lignum Aquilariae Resinatum 24 parts and JIZHUASHEN 11 parts.
5. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: 21 parts of Poria, 17 parts of Semen Armeniacae Amarum, raw pearl barley 27 parts, Flos Inulae 15 parts, 20 parts of Radix Rubiae, 16 parts of Flos Carthami, Radix Salviae Miltiorrhizae 23 parts, Caulis Perillae 18 parts, Radix Notoginseng 8 parts, Radix Curcumae 15 parts, Bulbus Fritillariae Uninbracteatae 13 parts, Fructus Trichosanthis 4 parts, Radix Glycyrrhizae Preparata 12 parts, Bulbus Lilii 19 parts, Arillus Longan 15 parts, Folium Eriobotryae 8 parts, Herba Eupatorii Lindleyani 16 parts, east 6 parts, Fructus Perillae 23 parts, drought Radix Peucedani 15 parts, Semen Raphani 10 parts, 15 parts of Semen Persicae, Ramulus Euonymi 11 parts, Herba Salviae Chinensis 15 parts, Lignum Aquilariae Resinatum 19 parts and JIZHUASHEN 7 parts.
6. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: 15 parts of Poria, 9 parts of Semen Armeniacae Amarum, raw pearl barley 16 parts, Flos Inulae 17 parts, 15 parts of Radix Rubiae, 13 parts of Flos Carthami, Radix Salviae Miltiorrhizae 14 parts, Caulis Perillae 13 parts, Radix Notoginseng 5 parts, Radix Curcumae 12 parts, Bulbus Fritillariae Uninbracteatae 15 parts, Fructus Trichosanthis 17 parts, Radix Glycyrrhizae Preparata 9 parts, Bulbus Lilii 14 parts, Arillus Longan 12 parts, Folium Eriobotryae 14 parts, Herba Eupatorii Lindleyani 18 parts, east 9 parts, Fructus Perillae 14 parts, drought Radix Peucedani 5 parts, Semen Raphani 15 parts, 24 parts of Semen Persicae, Ramulus Euonymi 8 parts, Herba Salviae Chinensis 9 parts, Lignum Aquilariae Resinatum 14 parts and JIZHUASHEN 16 parts.
7. according to the arbitrary described medicine of claim 1-6, it is characterised in that when the dosage form of described medicine is decoction, its preparation method comprises the following steps:
Step one: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to the dipped medical material upper surface 2-5cm of clear water, soak 3-10 hour；
Step 2: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts 30-50 minute slowly, filter, obtain filtrate a, standby；
Step 3: residue medicinal residues are added clear water again, to the dipped medical material upper surface 2-3cm of clear water, soaks 3-10 hour；
Step 4: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts 25-35 minute slowly, filter, obtain filtrate b, mixed by filtrate a and filtrate b.
8. according to the arbitrary described medicine of claim 1-6, it is characterised in that when the dosage form of described endo-medicine is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that alcohol volumetric concentration is 85%～95% relative to 4～8 times of mixture, heat to boiling reflux 3～5 hours, filter, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa is the mastic of 1.04～1.10, spray drying, the inlet temperature of spray dryer 160～175 DEG C, leaving air temp 80～85 DEG C, it is ground into powder subsequently, makes dried cream powder；
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.2～0.4 times and 0.1～0.2 times in the dried cream powder obtained, make granule, dries in 40～50 DEG C, it is thus achieved that granule.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610139603.9A CN105727179A (en) | 2016-03-14 | 2016-03-14 | Heart calming medicine and preparation method thereof |
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| CN201610139603.9A Pending CN105727179A (en) | 2016-03-14 | 2016-03-14 | Heart calming medicine and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657806A (en) * | 2012-05-18 | 2012-09-12 | 李承平 | Combination tablets for dissipating bruise, promoting the circulation of qi, activating yang and removing stasis |
| CN104173987A (en) * | 2014-09-03 | 2014-12-03 | 河南科技大学第一附属医院 | Traditional Chinese medicine for treating postpartum hemorrhage caused by blood stasis and qi obstruction and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657806A (en) * | 2012-05-18 | 2012-09-12 | 李承平 | Combination tablets for dissipating bruise, promoting the circulation of qi, activating yang and removing stasis |
| CN104173987A (en) * | 2014-09-03 | 2014-12-03 | 河南科技大学第一附属医院 | Traditional Chinese medicine for treating postpartum hemorrhage caused by blood stasis and qi obstruction and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 谢吟灵: "清脉汤加减辅助治疗肥胖型胸痹心痛临床研究", 《吉林中医药》 * |
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