CN105713066A - 在升高的温度下合成肽的改进偶联方法 - Google Patents

在升高的温度下合成肽的改进偶联方法 Download PDF

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Publication number
CN105713066A
CN105713066A CN201510959243.2A CN201510959243A CN105713066A CN 105713066 A CN105713066 A CN 105713066A CN 201510959243 A CN201510959243 A CN 201510959243A CN 105713066 A CN105713066 A CN 105713066A
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CN
China
Prior art keywords
coupling
carbodiimide
activation
peptide
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510959243.2A
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English (en)
Chinese (zh)
Inventor
J·M·柯林斯
S·K·辛格
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CEM Corp
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CEM Corp
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Filing date
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Publication of CN105713066A publication Critical patent/CN105713066A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/084—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
CN201510959243.2A 2014-12-19 2015-12-18 在升高的温度下合成肽的改进偶联方法 Pending CN105713066A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201462094420P 2014-12-19 2014-12-19
US62/094,420 2014-12-19
US201562111817P 2015-02-04 2015-02-04
US62/111,817 2015-02-04
US201562132847P 2015-03-13 2015-03-13
US62/132,847 2015-03-13
US14/969,004 2015-12-15
US14/969,004 US10308677B2 (en) 2014-12-19 2015-12-15 Coupling method for peptide synthesis at elevated temperatures

Publications (1)

Publication Number Publication Date
CN105713066A true CN105713066A (zh) 2016-06-29

Family

ID=55310608

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510959243.2A Pending CN105713066A (zh) 2014-12-19 2015-12-18 在升高的温度下合成肽的改进偶联方法

Country Status (6)

Country Link
US (1) US10308677B2 (https=)
EP (1) EP3037430B1 (https=)
JP (1) JP6348102B2 (https=)
CN (1) CN105713066A (https=)
AU (2) AU2015271886B2 (https=)
CA (1) CA2915484C (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114736286A (zh) * 2021-12-27 2022-07-12 杭州诺泰澳赛诺医药技术开发有限公司 一种多肽杂质单硫化物的合成方法
CN118812623A (zh) * 2024-07-02 2024-10-22 中肽生化有限公司 一种alpha取代氨基酸和氮烷基类甘氨酸相连多肽序列的固相合成方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
CA2907454C (en) 2013-03-21 2021-05-04 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
US9969769B2 (en) 2014-12-19 2018-05-15 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
AU2017221772B2 (en) * 2016-09-02 2018-07-05 Cem Corporation Use of excess carbodiimide for peptide synthesis at elevated temperatures
US10858390B2 (en) * 2016-09-02 2020-12-08 Cem Corporation Use of excess carbodiimide for peptide synthesis at elevated temperatures
CN113655133B (zh) * 2021-06-29 2023-03-10 北京诺康达医药科技股份有限公司 一种检测n,n-二异丙基碳二酰亚胺的方法及应用
WO2023195516A1 (ja) * 2022-04-08 2023-10-12 中外製薬株式会社 ペプチド化合物の製造方法

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GB673639A (en) 1948-07-02 1952-06-11 Ward Blenkinsop & Co Ltd Process for the production of acyl derivatives of amino hydroxybenzene carboxylic acids
GB812543A (en) 1954-12-06 1959-04-29 Roussel Uclaf Improvements in or relating to ª‡-amino acids and peptides derived therefrom
US4507230A (en) 1982-05-12 1985-03-26 Research Corporation Peptide synthesis reagents and method of use
JPS6393796A (ja) 1986-10-09 1988-04-25 Shin Etsu Chem Co Ltd ペプチド合成の脱保護基用薬剤
EP0322348B1 (de) 1987-12-22 1994-02-02 Hoechst Aktiengesellschaft Säurelabile Ankergruppen zur Synthese von Peptidamiden mittels Festphasenmethode
DE4124283A1 (de) 1991-07-15 1993-01-21 Degussa Umesterung von peptiden
PL338457A1 (en) 1997-07-31 2000-11-06 Elan Pharm Inc Sulphonylated dipeptidic compounds capable to inhibit adhesion of leucocytes through the mediation of vla-4
MXPA02007231A (es) 2000-01-27 2002-12-09 Lilly Co Eli Proceso para solubilizar los compuestos de peptido 1 similares a glucagon.
CZ299141B6 (cs) 2000-12-22 2008-04-30 Ipsen Manufacturing Ireland Limited Zpusob syntézy peptidu LHRH
GB0227876D0 (en) 2002-11-29 2003-01-08 Avecia Ltd Process and supports
US7393920B2 (en) * 2003-06-23 2008-07-01 Cem Corporation Microwave-assisted peptide synthesis
ATE376556T1 (de) 2003-12-31 2007-11-15 Hoffmann La Roche Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel
DE102004053410A1 (de) 2004-11-05 2006-05-11 Bayer Healthcare Ag Cyclische Nonadepsipeptidamide
JP6112011B2 (ja) 2011-05-31 2017-04-12 味の素株式会社 ペプチドの製造方法
US20140206841A1 (en) 2013-01-18 2014-07-24 Protein Technologies, Inc. Peptide Synthesis Apparatus and Methods Using Infrared Energy

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JONATHAN M COLLINS ET AL: "High-efficiency solid phase peptide synthesis(HE-SPPS)", 《ORGANIC LETTERS》 *
M BEYERMANN ET AL: "Effect of tertiary amine on the carbodiimide-mediated peptide synthesis", 《INT J PEPTIDE PROTEIN RES》 *
RAMON SUBIROS-FUNOSAS ET AL: "Oxyma:an efficient additive for peptide synthesis to replace the benzotriazole-based HOBt and HOAt with lower risk of explosion", 《CHEM EUR J》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114736286A (zh) * 2021-12-27 2022-07-12 杭州诺泰澳赛诺医药技术开发有限公司 一种多肽杂质单硫化物的合成方法
CN118812623A (zh) * 2024-07-02 2024-10-22 中肽生化有限公司 一种alpha取代氨基酸和氮烷基类甘氨酸相连多肽序列的固相合成方法

Also Published As

Publication number Publication date
JP6348102B2 (ja) 2018-06-27
EP3037430A1 (en) 2016-06-29
AU2017204172B2 (en) 2017-10-05
CA2915484A1 (en) 2016-06-19
JP2016138090A (ja) 2016-08-04
US10308677B2 (en) 2019-06-04
EP3037430B1 (en) 2019-12-04
US20160176918A1 (en) 2016-06-23
AU2017204172A1 (en) 2017-07-13
CA2915484C (en) 2019-01-15
AU2015271886A1 (en) 2016-07-07
AU2015271886B2 (en) 2017-08-03

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Effective date of abandoning: 20201127