CN105688069A - 一种治疗心肌缺血的中药组合物及其制备方法 - Google Patents
一种治疗心肌缺血的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明属于中医药技术领域,目的是根据中医对心肌缺血的认识机理而提供的一种治疗心肌缺血的中药组合物,所述药物的各个组分及其质量份比如下:党参、白芍、龙眼肉、陈皮、香附、郁金、生黄芪、西洋参、山药、甘草、石菖蒲、安息香、远志、熟地黄、何首乌、沙参、石斛、玉竹、天门、酸枣仁、丹参、红花、桃仁、川芎、神曲、麦芽、人参、白术、苏合香、冰片、生地黄、牡蛎(煅)、合欢皮、夜交藤、灵芝、柏子仁、莲子(去心);本发明提供的药物是一个标本兼治的中药组方。
Description
技术领域
本发明涉及中医药技术领域,具体涉及一种治疗心肌缺血的中药组合物,特别是供心肌缺血患者使用的中药组合物及其制备方法的领域。
背景技术
心肌缺血(myocardialischemia)是指心脏的血液灌注减少,导致心脏的供氧减少,心肌能量代谢不正常,不能支持心脏正常工作的一种病理状态。心脏活动所需要的能量几乎完全靠有氧代谢提供,所以即便在安静的时候,心肌的血氧摄取率也很高(为70%以上),正常情况下,机体可通过自身调节,促使血液供需相对恒定,保证心脏正常工作。当某种原因导致心肌血液供需失衡,就构成了真正意义上的心肌缺血。而冠心病是引起心肌缺血最主要、最常见的病因。随着人民生活水平的提高,目前心肌缺血在我国的患病率呈逐年上升的趋势,已成为中老年人的常见病和多发病,并且有一些20~30岁的年轻人也出现心肌缺血的表现。
那么,就如何找到一种可有效治疗心肌缺血的中药组合物,是我们目前急需要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗心肌缺血上,人们逐渐意识到了中医治疗上述心肌缺血的优点,且在治疗过程中毒副作用小、费用低等优势,针对现有西医治疗上述心肌缺血的现状,本发明的目的是在于提供一种治疗心肌缺血的中药组合物,以解决心肌缺血患者早日恢复健康的问题。该药物是以常见的中药为原料,具有见效快、疗效显著等特点,并可有效治疗上述心肌缺血一症。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种治疗心肌缺血的中药组合物及其制备方法,其特征在于,所述中药组合物的各个组分及其质量份比如下所示:
党参15~28g、白芍10~21g、龙眼肉10~18g、陈皮3~10g、香附8~16g、郁金8~16g、生黄芪9~32g、西洋参5~12g、山药15~30g、甘草3~9g、石菖蒲5~10g、安息香0.3~1.8g、远志3~10g、熟地黄12~32g、何首乌6~15g、沙参10~16g、石斛6~16g、玉竹10~16g、天门冬6~16g、酸枣仁6~16g、丹参8~16g、红花3~12g、桃仁8~16g、川芎3~10g、神曲10~16g、麦芽9~16g、人参3~16g、白术3~16g、苏合香0.3~1.2g、冰片0.15~0.35g、生地黄10~28g、牡蛎(煅)15~42g、合欢皮10~16g、夜交藤10~22g、灵芝10~16g、柏子仁3~16g、莲子(去心)3~18g。
一种治疗心肌缺血的中药组合物及其制备方法,其特征在于,所述中药组合物的各个组分及其质量份比如下所示:
党参18~25g、白芍12~18g、龙眼肉11~16g、陈皮6~9g、香附10~14g、郁金10~14g、生黄芪15~28g、西洋参8~11g、山药18~26g、甘草6~8g、石菖蒲6~9g、安息香0.5~1.5g、远志6~9g、熟地黄18~28g、何首乌8~13g、沙参11~14g、石斛10~14g、玉竹11~14g、天门冬10~14g、酸枣仁8~14g、丹参10~14g、红花8~11g、桃仁10~14g、川芎6~9g、神曲11~14g、麦芽10~14g、人参8~14g、白术6~14g、苏合香0.5~1.1g、冰片0.18~0.32g、生地黄15~25g、牡蛎(煅)18~36g、合欢皮11~14g、夜交藤12~20g、灵芝11~14g、柏子仁8~14g、莲子(去心)8~16g。
一种治疗心肌缺血的中药组合物及其制备方法,其特征在于,所述“最佳方案”的中药组合物的各个组分及其质量份比如下所示:
党参22g、白芍16g、龙眼肉15g、陈皮8g、香附13g、郁金13g、生黄芪25g、西洋参10g、山药23g、甘草7g、石菖蒲8g、安息香1.2g、远志8g、熟地黄25g、何首乌12g、沙参13g、石斛13g、玉竹13g、天门冬13g、酸枣仁13g、丹参13g、红花10g、桃仁13g、川芎8g、神曲13g、麦芽13g、人参13g、白术13g、苏合香1g、冰片0.30g、生地黄22g、牡蛎(煅)32g、合欢皮13g、夜交藤17g、灵芝13g、柏子仁13g、莲子(去心)15g。
一种治疗心肌缺血的中药组合物及其制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、将上述原料中药拣去杂质和粉尘后,按照质量份比共研为极细末待用;
B、按照传统制备中药水丸剂的方法,将上述研磨好的极细末药物过筛后,放入药器中混合拌均,然后制备成水丸剂(其水丸的粒度为:4.6mm-4.8mm),继而晒干,分装密封备用。
一种治疗心肌缺血的中药组合物及其制备方法,其特征在于,所述服用方法为:将制备好的水丸以每日二次服用,早晚各服一次,给药量5.5g/次,饭前服,服药15~45天,病情明显好转或痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
党参,性味:味甘、性平,具有健脾补肺、益气生津之功效,用于治疗脾胃虚弱、食少便溏、四肢乏力、肺虚喘咳、气短自汗、气微两亏等症;
白芍,性味:味苦、酸、性凉,具有疏肝理气、柔肝养血、缓中止痛、平肝敛阴之功效,用于治疗肝胃不和所致的胸胁胀痛、脘腹疼痛、月经不调、经行腹痛、崩漏,以及自汗、盗汗、头痛、眩晕等病症;
龙眼肉,性味:甘、温,具有补心脾、益气血、安心神之功效,用于治疗心脾两虚、气血不足所致的惊悸、怔忡、失眠、健忘、血虚萎黄、有经不调、崩漏;
陈皮,性味:苦、辛、温,具有理气健脾、调中、燥湿、化痰之功效,用于治疗脾胃气滞之脘腹胀满或疼痛、消化不良、湿浊阻中之胸闷腹胀、纳呆便溏、痰湿壅肺之咳嗽气喘、食少吐泻、咳嗽痰多等症;
香附,性味:味辛、微寒,无毒,具有理气解郁、调经止痛、安胎之功效,用于治疗胁肋胀痛、乳房胀育、疝气疼痛、月经不调、脘腹痞满疼痛、嗳气吞酸、呕恶、经行腹痛、崩漏带下、胎动不安、消化不良等症;
郁金,性味:味辛、苦、性寒,具有活血止痛、行气解郁、清心凉血、疏肝利胆之功效,用于治疗胸腹胁肋诸痛、妇女痛经、经闭、症瘕结块、热病神昏、癫狂、惊痫、吐血、衄备、血淋、砂淋、黄疸等症;
生黄芪,性味:甘、温,具有补气固表、利尿消肿、托毒排脓、敛疮生肌、生肌之功效,用于治疗气虚乏力、食少便溏、中气下陷、久泻脱肛、便血崩漏、表虚自汗、气虚水肿、痈疽难溃、久溃不敛、血虚痿黄、内热消渴、慢性肾炎蛋白尿、糖尿病;生黄芪多用于固表、托疮、利水等;蜜炙黄芪多用于补中益气;炒黄芪多用于益气健脾等病症;
西洋参,性味:味微苦、甘,具有益肺阴、清虚火、生津止渴之功效,用于治疗肺虚久嗽、失血、咽干口渴、虚热烦倦;
山药,性味:甘、平,具有补脾、养肺、固肾、益精之功效,用于治疗脾虚泄泻、食少浮肿、肺虚咳喘、消渴、遗精、带下、肾虚尿频,外用治痈肿、瘰疬等症;
甘草,性味:甘、平,具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药之功效,用于治疗倦怠食少、肌瘦面黄、心悸气短、腹痛便溏、四肢挛急疼痛、脏躁、咳嗽气喘、咽喉肿痛、痈疮肿痛、小儿胎毒及药物、食物中毒等症;
石菖蒲,性味:味辛、苦、性微温,具有化痰开窍、化湿行气、祛风利痹、消肿止痛之功效,用于治疗热病神昏、痰厥、健忘、耳鸣、耳聋、脘腹胀痛、噤口痢、风湿痹痛、跌打损伤、痈疽疥癣等症;
安息香,性味:辛、苦、性平,具有开窍醒神、豁痰辟秽、行气活血、止痛之功效,用于治疗中风痰劂、惊痫昏迷、产后血晕、心腹疼痛、风痹肢节痛;
远志,性味:苦、辛、微温,具有安神益智、祛痰、消肿之功效,用于治疗心肾不交引起的失眠多梦、健忘惊悸、神志恍惚、咳痰不爽、疮疡肿毒、乳房肿痛;
熟地黄,性味:甘、微温,具有滋阴补血、益精填髓之功效,用于治疗肝肾阴虚、腰膝酸软、骨蒸潮热、盗汗遗精、内热消渴、血虚萎黄、心悸怔忡、月经不调、崩漏下血、眩晕、耳鸣、须发早白;
何首乌,性味:甘、苦、涩、性温,具有解毒、消痈、润肠通便之功效,用于治疗瘰疠疮痈、风疹瘙痒、肠燥便秘、高血脂;
沙参,性味:味甘、微苦、性微寒,具有养阴清热、润肺化痰、益胃生津之功效,用于治疗阴虚久咳、痨嗽痰血、燥咳痰少、虚热喉痹、津伤口渴;
石斛,性味:微寒、甘,具有益胃生津、滋阴清热之功效,用于治疗阴伤津亏、口干烦渴、食少干呕、病后虚热、目暗不明;
玉竹,性味:甘、平,具有养阴、润燥、除烦、止渴之功效,用于治疗热病阴伤、咳嗽烦渴、虚劳发热、消谷易饥、小便频数等病症;
天门冬,性味:味甘苦、性寒,具有有滋阴、润燥、清肺、降火之功效,用于治疗阴虚发热、咳嗽吐血、肺痿、肺痈、咽喉肿痛、消渴、便秘;
酸枣仁,性味:甘、平,具有宁心安神、养肝、敛汗之功效,用于治疗虚烦不眠、惊悸怔忡、体虚自汗、盗汗;
丹参,性味:味苦、性微寒,具有活血祛瘀、调经止痛、养血安神、凉血消痈之功效,用于治疗妇女月经不调、痛经、经闭、产后瘀滞腹痛、心腹疼痛、症瘕积聚、热痹肿痛、跌打损伤、热入营血、烦躁不安、心烦失眠、痈疮肿毒等症;
红花,性味:性温、味辛,具有活血通经、散瘀止痛之功效,用于治疗经闭、痛经、跌打损伤、恶露不行,症瘕痞块,痔疮肿痛等病症;
桃仁,性味:苦甘、平,具有破血行瘀、润燥滑肠之功效,用于治疗经闭、癥瘕、热病蓄血、风痹、疟疾、跌打损伤、瘀血肿痛、血燥便秘;
川芎,性味:辛、温,具有活血行气、祛风止痛之功效,用于治疗安抚神经、正头风头痛、症瘕腹痛、胸胁刺痛、跌扑肿痛、头痛、风湿痹痛;
神曲,性味:苦、温,具有健脾消食、理气化湿、解表之功效,用于治疗伤食胸痞、腹痛吐泻、痢疾、感冒头痛、小儿伤饥失饱等病症;
麦芽,性味:味甘、性平,具有消食、和中、下气之功效,用于治疗食积不消、脘腹胀满、食欲不振、呕吐泄泻、乳胀不消等病症;
人参,性味:性平、味甘、微苦,具有大补元气、复脉固脱、补脾益肺、生津止渴、安神益智之功效,用于治疗劳伤虚损、食少、倦怠、反胃吐食、大便滑泄、虚咳喘促、自汗暴脱、惊悸、健忘、眩晕头痛、阳痿、尿频、消渴、妇女崩漏、小儿慢惊及久虚不复,一切气血津液不足之证;
白术,性味:味苦、甘、性温,具有健脾益气、燥湿利水、止汗、安胎之功效,用于治疗脾气虚弱、神疲乏力、食少少腹胀、大便溏薄、水饮内停、小便不利、水肿、痰饮眩晕、温痹酸痛、气虚自汗、胎动不安;
苏合香,性味:辛、甘、温,具有通窍辟秽、开郁豁痰、行气止痛之功效,用于治疗中风、痰厥、气厥之寒闭症、温疟、惊痫、湿浊吐利、心腹卒痛以及冻疮、疥癣;
冰片,性味:辛、苦、微寒,具有开窍醒神、清热止痛之功效,用于治疗热病神昏、痉厥、中风痰厥、气郁暴厥、中恶昏迷、目赤、口疮、咽喉肿痛、耳道流脓等症;
生地黄,性味:味甘、苦、性寒,具有清热、凉血之功效,用于治疗温热病热入营血、壮热神昏、口干舌绛;
牡蛎(煅),性味:味咸、性微寒,具有平肝潜阳、重镇安神、软坚散结、收敛固涩之功效,用于治疗眩晕耳鸣、惊悸失眠、瘰疬瘿瘤、症瘕痞块、自汗盗汗、遗精、崩漏、带下等症;
合欢皮,性味:甘、平,具有安神解郁、活血消痈之功效,用于治疗心神不安、忧郁、不眠、内外痈疡、跌打损伤;
夜交藤,性味:甘、微苦、性平,具有养心安神、祛风、通络之功效,用于治疗失眠、多梦、血虚身痛、肌肤麻木、风湿痹痛、风疹瘙痒;
灵芝,性味:甘、平,无毒,具有益气血、安心神、健脾胃之功效,用于治疗虚劳、心悸、失眠、头晕、神疲乏力、久咳气喘、冠心病、矽肺、肿瘤等症;
柏子仁,性味:甘、性平,具有养心安神、敛汗、润肠通便之功效,用于治疗惊悸怔忡、失眠健忘、盗汗、肠燥便秘;
莲子(去心),性味:性平、味甘、涩,具有补脾止泻、益肾涩清、养心安神之功效,用于治疗脾虚久泻、遗精带下、心悸失眠,主治夜寐多梦、失眠、健忘、心烦口渴、腰痛脚弱、耳目不聪、遗精、淋浊、久痢、虚泻、妇女崩漏带下以及胃虚不欲饮食等病症。
本发明药物是基于中医治疗心肌缺血的辨病与辨证相结合的原则,从药理作用及作用机制认为:就心肌缺血一症,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述心肌缺血的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个标本兼治的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种治疗心肌缺血的中药组合物,其特征在于,所述中药组合物的各个组分及质量份比如下所示:
党参22g、白芍16g、龙眼肉15g、陈皮8g、香附13g、郁金13g、生黄芪25g、西洋参10g、山药23g、甘草7g、石菖蒲8g、安息香1.2g、远志8g、熟地黄25g、何首乌12g、沙参13g、石斛13g、玉竹13g、天门冬13g、酸枣仁13g、丹参13g、红花10g、桃仁13g、川芎8g、神曲13g、麦芽13g、人参13g、白术13g、苏合香1g、冰片0.30g、生地黄22g、牡蛎(煅)32g、合欢皮13g、夜交藤17g、灵芝13g、柏子仁13g、莲子(去心)15g。
实施例2:
一种治疗心肌缺血的中药组合物,其特征在于,所述中药组合物的各个组分及质量份比如下所示:
党参25g、白芍18g、龙眼肉16g、陈皮9g、香附14g、郁金14g、生黄芪28g、西洋参11g、山药26g、甘草8g、石菖蒲9g、安息香1.5g、远志9g、熟地黄28g、何首乌13g、沙参14g、石斛14g、玉竹14g、天门冬14g、酸枣仁14g、丹参14g、红花11g、桃仁14g、川芎9g、神曲14g、麦芽14g、人参14g、白术14g、苏合香1.1g、冰片0.32g、生地黄25g、牡蛎(煅)36g、合欢皮14g、夜交藤20g、灵芝14g、柏子仁14g、莲子(去心)16g。
实施例3:
一种治疗心肌缺血的中药组合物,其特征在于,所述中药组合物的各个组分及质量份比如下所示:
党参28g、白芍21g、龙眼肉18g、陈皮10g、香附16g、郁金16g、生黄芪32g、西洋参12g、山药30g、甘草9g、石菖蒲10g、安息香1.8g、远志10g、熟地黄32g、何首乌15g、沙参16g、石斛16g、玉竹16g、天门冬16g、酸枣仁16g、丹参16g、红花12g、桃仁16g、川芎10g、神曲16g、麦芽16g、人参16g、白术16g、苏合香1.2g、冰片0.35g、生地黄28g、牡蛎(煅)42g、合欢皮16g、夜交藤22g、灵芝16g、柏子仁16g、莲子(去心)18g。
典型病例:
经临床诊断治疗心肌缺血患者共160例,年龄为55岁以上的107例,只有53例为55岁以下。160例患者中痊愈的95例,显效的65例,总有效率达100%。经治疗后,病情明显好转或痊愈。
Claims (3)
1.一种治疗心肌缺血的中药组合物,其特征在于,所述中药组合物的各个组分及其质量份比如下所示:
党参15~28g、白芍10~21g、龙眼肉10~18g、陈皮3~10g、香附8~16g、郁金8~16g、生黄芪9~32g、西洋参5~12g、山药15~30g、甘草3~9g、石菖蒲5~10g、安息香0.3~1.8g、远志3~10g、熟地黄12~32g、何首乌6~15g、沙参10~16g、石斛6~16g、玉竹10~16g、天门冬6~16g、酸枣仁6~16g、丹参8~16g、红花3~12g、桃仁8~16g、川芎3~10g、神曲10~16g、麦芽9~16g、人参3~16g、白术3~16g、苏合香0.3~1.2g、冰片0.15~0.35g、生地黄10~28g、牡蛎(煅)15~42g、合欢皮10~16g、夜交藤10~22g、灵芝10~16g、柏子仁3~16g、莲子(去心)3~18g。
2.根据权利要求1所述的治疗心肌缺血的中药组合物,其特征在于,所述中药组合物的各个组分及其质量份比如下所示:
党参18~25g、白芍12~18g、龙眼肉11~16g、陈皮6~9g、香附10~14g、郁金10~14g、生黄芪15~28g、西洋参8~11g、山药18~26g、甘草6~8g、石菖蒲6~9g、安息香0.5~1.5g、远志6~9g、熟地黄18~28g、何首乌8~13g、沙参11~14g、石斛10~14g、玉竹11~14g、天门冬10~14g、酸枣仁8~14g、丹参10~14g、红花8~11g、桃仁10~14g、川芎6~9g、神曲11~14g、麦芽10~14g、人参8~14g、白术6~14g、苏合香0.5~1.1g、冰片0.18~0.32g、生地黄15~25g、牡蛎(煅)18~36g、合欢皮11~14g、夜交藤12~20g、灵芝11~14g、柏子仁8~14g、莲子(去心)8~16g。
3.根据权利要求1至2所述的治疗心肌缺血的中药组合物,其特征在于,所述中药组合物的各个组分及其质量份比如下所示:
党参22g、白芍16g、龙眼肉15g、陈皮8g、香附13g、郁金13g、生黄芪25g、西洋参10g、山药23g、甘草7g、石菖蒲8g、安息香1.2g、远志8g、熟地黄25g、何首乌12g、沙参13g、石斛13g、玉竹13g、天门冬13g、酸枣仁13g、丹参13g、红花10g、桃仁13g、川芎8g、神曲13g、麦芽13g、人参13g、白术13g、苏合香1g、冰片0.30g、生地黄22g、牡蛎(煅)32g、合欢皮13g、夜交藤17g、灵芝13g、柏子仁13g、莲子(去心)15g。
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