CN105687839A - Traditional Chinese medicine composition for treating lung cancer, cough and hemoptysis - Google Patents

Traditional Chinese medicine composition for treating lung cancer, cough and hemoptysis Download PDF

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Publication number
CN105687839A
CN105687839A CN201610107982.3A CN201610107982A CN105687839A CN 105687839 A CN105687839 A CN 105687839A CN 201610107982 A CN201610107982 A CN 201610107982A CN 105687839 A CN105687839 A CN 105687839A
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parts
radix
herba
chinese medicine
medicine composition
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李朝彬
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to a traditional Chinese medicine composition for treating a lung cancer, a cough and hemoptysis. The traditional Chinese medicine composition is prepared from, by weight, radix codonopsis, milkvetch roots, poria cocos, rhizoma atractylodis macrocephalae, common yam rhizomes, roots of straight ladybell, lilies, radix ophiopogonis, Chinese magnoliavine fruit, honey-fried licorice roots, radix scutellariae, India madder roots, dried rehamnnia roots, cacumen biotae, colla corii asini, white mulberry root-bark, almond kernels, cortex lycii radicis, sea clam meal, sweet wormwood herb, root-bark of tree peony, fructus gardeniae, lalang grass rhizomes, hairyvein agrimonia herb and buds, herba ecliptae, radix gentianae, common bletilla tuber powder, panax notoginseng powder, tendril-leaved fritillary bulbs, radix angelica sinensis, lotus rhizome nodes, lotus leaves, rhizoma paridis, barbed skullcap herb, Chinese lobelia herb, spreading hedyotis herb, black nightshade herb, muskroot-like semiaquilegia roots and dandelions. According to the traditional Chinese medicine composition for treating the lung cancer, the cough and the hemoptysis, the effects of dissolving blood stasis, achieving detoxication, reinforcing the lung to replenish qi, tonifying the spleen, regulating qi and tonifying the stomach serve as therapeutic principles, the whole body mechanism is regulated, nidi are removed, both symptoms and root causes are treated, therefore, cachexia is improved, the life quality is improved, and the lifetime is prolonged.

Description

A kind of Chinese medicine composition treating pulmonary carcinoma, cough, spitting of blood
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of Chinese medicine composition treating pulmonary carcinoma, cough, spitting of blood.
Background technology
Pulmonary carcinoma is that M & M growth is the fastest, one of malignant tumor maximum to population health and life threat. the many countries of immediate and mid-term all report that the M & M of pulmonary carcinoma all substantially increases, male lung cancer M & M all accounts for first of all malignant tumor, women sickness rate accounts for second, mortality rate accounts for second. and the cause of disease of pulmonary carcinoma is so far still not exclusively clearly, great mass of data shows, long-term a large amount of smoking has very close relationship with pulmonary carcinoma. and existing research proves: the probability that long-term a large amount of smokers suffer from pulmonary carcinoma is 10～20 times of non-smoker, the age starting smoking is more little, the probability suffering from pulmonary carcinoma is more high. in addition, smoking not only directly affects my healthy, also the health of surrounding population is produced harmful effect, causing that involuntary smoker's pulmonary carcinoma prevalence substantially increases. the sickness rate of urbanite's pulmonary carcinoma is higher than rural area, this is likely to relevant containing carcinogen with urban atmospheric pollution and flue dust. therefore should advocate non-smoking, and strengthen city environmental hygiene work. for this, it is bursting to and develops more medicine safely and effectively treating pulmonary carcinoma and meet the needs of clinical treatment.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition treating pulmonary carcinoma, cough, spitting of blood.
In order to realize the purpose of the present invention, the present invention provides one to treat pulmonary carcinoma, cough, the Chinese medicine composition of spitting of blood, it comprises the material of following weight portion: Radix Codonopsis 15-30 part, Radix Astragali 15-30 part, Poria 15-20 part, Rhizoma Atractylodis Macrocephalae 15-30 part, Rhizoma Dioscoreae 30 parts, Radix Adenophorae (Radix Glehniae) 12-15 part, Bulbus Lilii 12-15 part, Radix Ophiopogonis 12-15 part, Fructus Schisandrae Chinensis 10-15 part, Radix Glycyrrhizae Preparata 5-15 part, Radix Scutellariae 15-30 part, Radix Rubiae 12-15 part, Radix Rehmanniae 15-20 part, Cacumen Platycladi 12-15 part, Colla Corii Asini 5-15 part, Cortex Mori 12-15 part, Semen Armeniacae Amarum 10-15 part, Cortex Lycii 10-15 part, sea clam powder 5-15 part, Herba Artemisiae Annuae 5-15 part, Cortex Moutan 10-20 part, Fructus Gardeniae 10-20 part, Rhizoma Imperatae 20-40 part, Herba Agrimoniae 15-30 part, Herba Ecliptae 15-30 part, Radix Gentianae 10-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 10-12 part, Radix Notoginseng powder 6-12 part, Bulbus Fritillariae Cirrhosae 5-15 part, Radix Angelicae Sinensis 5-15 part, Nodus Nelumbinis Rhizomatis 15-30 part, Folium Nelumbinis 12-15 part, Rhizoma Paridis 5-15 part, Herba Scutellariae Barbatae 15-30 part, Herba Lobeliae Chinensis 15-30 part, Herba Hedyotidis Diffusae 15-30 part, Herba Solani Nigri 15-30 part, Radix Semiaquilegiae 10-20 part and Herba Taraxaci 15-30 part.
Preferably, treatment pulmonary carcinoma of the present invention, cough, the Chinese medicine composition of spitting of blood comprises the material of following weight portion: Radix Codonopsis 20 parts, the Radix Astragali 20 parts, 18 parts of Poria, the Rhizoma Atractylodis Macrocephalae 20 parts, Rhizoma Dioscoreae 30 parts, Radix Adenophorae (Radix Glehniae) 13 parts, Bulbus Lilii 13 parts, Radix Ophiopogonis 13 parts, Fructus Schisandrae Chinensis 12 parts, Radix Glycyrrhizae Preparata 10 parts, Radix Scutellariae 20 parts, 13 parts of Radix Rubiae, 18 parts of the Radix Rehmanniae, Cacumen Platycladi 13 parts, 10 parts of Colla Corii Asini, Cortex Mori 13 parts, 12 parts of Semen Armeniacae Amarum, Cortex Lycii 12 parts, 10 parts of sea clam powder, Herba Artemisiae Annuae 10 parts, Cortex Moutan 10-20 part, Fructus Gardeniae 10-20 part, Rhizoma Imperatae 30 parts, Herba Agrimoniae 20 parts, Herba Ecliptae 20 parts, Radix Gentianae 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 11 parts, Radix Notoginseng powder 10 parts, Bulbus Fritillariae Cirrhosae 10 parts, Radix Angelicae Sinensis 10 parts, Nodus Nelumbinis Rhizomatis 20 parts, 13 parts of Folium Nelumbinis, Rhizoma Paridis 10 parts, Herba Scutellariae Barbatae 20 parts, Herba Lobeliae Chinensis 20 parts, Herba Hedyotidis Diffusae 20 parts, Herba Solani Nigri 20 parts, Radix Semiaquilegiae 15 parts and Herba Taraxaci 20 parts.
It is highly preferred that treatment pulmonary carcinoma of the present invention, cough, spitting of blood Chinese medicine composition also comprise the material of following weight portion: the material with following structural of 0.1 part:
Preferably, described Chinese medicine composition can be lotion, ointment or powder.
The present invention also provides for the material with following structural and treats the purposes in the medicine of pulmonary carcinoma, cough, spitting of blood in preparation:
The present invention regulates the flow of vital energy stomach invigorating for Therapeutic Principle with dissolving blood stasis and detoxication, invigorating the lung and benefiting vital QI, spleen invigorating, from conditioning general physical mechanism, to except focus, treating both the principal and secondary aspects of a disease, thus improving cachexia, and quality of making the life better, extend life cycle.
Detailed description of the invention
Further illustrate the present invention by the examples below. it should be understood that; embodiments of the invention are an illustration for the present invention rather than limitation of the present invention. broadly fall into the scope of protection of present invention according to the simple modifications that the present invention is carried out by the essence of the present invention. unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment 1
Weigh Radix Codonopsis 20 grams, the Radix Astragali 20 grams, 18 grams of Poria, the Rhizoma Atractylodis Macrocephalae 20 grams, Rhizoma Dioscoreae 30 grams, Radix Adenophorae (Radix Glehniae) 13 grams, Bulbus Lilii 13 grams, Radix Ophiopogonis 13 grams, Fructus Schisandrae Chinensis 12 grams, Radix Glycyrrhizae Preparata 10 grams, Radix Scutellariae 20 grams, 13 grams of Radix Rubiae, 18 grams of the Radix Rehmanniae, Cacumen Platycladi 13 grams, Ah limb 10 grams, Cortex Mori 13 grams, 12 grams of Semen Armeniacae Amarum, Cortex Lycii 12 grams, 10 grams of sea clam powder, Herba Artemisiae Annuae 10 grams, Cortex Moutan 10-20 gram, Fructus Gardeniae 10-20 gram, Rhizoma Imperatae 30 grams, Herba Agrimoniae 20 grams, Herba Ecliptae 20 grams, Radix Gentianae 12 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 11 grams, Radix Notoginseng powder 10 grams, Bulbus Fritillariae Cirrhosae 10 grams, Radix Angelicae Sinensis 10 grams, Nodus Nelumbinis Rhizomatis 20 grams, 13 grams of Folium Nelumbinis, Rhizoma Paridis 10 grams, Herba Scutellariae Barbatae 20 grams, Herba Lobeliae Chinensis 20 grams, Herba Hedyotidis Diffusae 20 grams, Herba Solani Nigri 20 grams, Radix Semiaquilegiae 15 grams and Herba Taraxaci 20 grams, pulverize, add 10000 milliliters of water, the heating 3 hours when backflow, filter, filtrate is made to be cooled to room temperature, then through the filtering with microporous membrane of 0.22 μm, obtain solution 1.
Embodiment 2
Weigh 0.1 gramAdd 50000 ml sterile waters, ultrasonic 30 minutes, the then filtering with microporous membrane of 0.22 μm, obtain solution 2.
Experimental example
MTT (available from Sigma) physiological saline solution, is configured to the working solution of 5mg/mL ,-20 DEG C of preservations；Dimethyl sulfoxide (DMSO) produces for Xi'an chemical reagent factory, analytical pure.
Method of testing
Take the logarithm the tumor cell of trophophase, cell density is adjusted to 2 × 105Individual/mL, is added in 96 porocyte culture plates by every hole 200 μ L, passes into 5%CO in 37 DEG C2Incubator in cultivate 4h. sample set 5 Concentraton gradient respectively, each concentration sets 3 Duplicate Samples, set the positive, negative control simultaneously, every hole adds sample liquid or each 2 μ L of blank solution, cultivate 72h, then every hole adds MTT liquid 10 μ L, continue to cultivate 4h, 37 DEG C, 2000r/min is centrifuged 8min, sucking supernatant. every hole adds each 100 μ L of DMSO and vibrate on micro oscillator 15min, after being completely dissolved to crystallization, the light absorption value (OD value) at microplate reader mensuration 570nm place, every hole. take three hole mean OD value by IR%=(ODComparison-ODSample)/ODComparison× 100% suppression ratio (IR%) calculating sample on cell proliferation.
Human small cell lung carcinoma cell strain NCI-H446, purchased from Bei Nuo bio tech ltd, Shanghai, adopts mtt assay, carries out anti tumor activity in vitro evaluation with amycin for positive control drug, and result is as follows:
Sample Concentration (μM) OD value Suppression ratio % 2-->
Blank group 112±0.05
Matched group 109±0.03
Amycin 05 0.25±0.01 77.06
Solution 1 50 0.39±0.01 64.22
Solution 2 50 0.31±0.01 66.67
For human small cell lung carcinoma cell strain NCI-H446, be there is In-vitro Inhibitory Effect from the above results, solution 1 and solution 2。

Claims (5)

1. a treatment pulmonary carcinoma, cough, the Chinese medicine composition of spitting of blood, it is characterised in that it comprises the material of following weight portion: Radix Codonopsis 15-30 part, Radix Astragali 15-30 part, Poria 15-20 part, Rhizoma Atractylodis Macrocephalae 15-30 part, Rhizoma Dioscoreae 30 parts, Radix Adenophorae (Radix Glehniae) 12-15 part, Bulbus Lilii 12-15 part, Radix Ophiopogonis 12-15 part, Fructus Schisandrae Chinensis 10-15 part, Radix Glycyrrhizae Preparata 5-15 part, Radix Scutellariae 15-30 part, Radix Rubiae 12-15 part, Radix Rehmanniae 15-20 part, Cacumen Platycladi 12-15 part, Colla Corii Asini 5-15 part, Cortex Mori 12-15 part, Semen Armeniacae Amarum 10-15 part, Cortex Lycii 10-15 part, sea clam powder 5-15 part, Herba Artemisiae Annuae 5-15 part, Cortex Moutan 10-20 part, Fructus Gardeniae 10-20 part, Rhizoma Imperatae 20-40 part, Herba Agrimoniae 15-30 part, Herba Ecliptae 15-30 part, Radix Gentianae 10-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 10-12 part, Radix Notoginseng powder 6-12 part, Bulbus Fritillariae Cirrhosae 5-15 part, Radix Angelicae Sinensis 5-15 part, Nodus Nelumbinis Rhizomatis 15-30 part, Folium Nelumbinis 12-15 part, Rhizoma Paridis 5-15 part, Herba Scutellariae Barbatae 15-30 part, Herba Lobeliae Chinensis 15-30 part, Herba Hedyotidis Diffusae 15-30 part, Herba Solani Nigri 15-30 part, Radix Semiaquilegiae 10-20 part and Herba Taraxaci 15-30 part。
2. treatment pulmonary carcinoma according to claim 1, cough, the Chinese medicine composition of spitting of blood, it is characterized in that, it comprises the material of following weight portion: Radix Codonopsis 20 parts, the Radix Astragali 20 parts, 18 parts of Poria, the Rhizoma Atractylodis Macrocephalae 20 parts, Rhizoma Dioscoreae 30 parts, Radix Adenophorae (Radix Glehniae) 13 parts, Bulbus Lilii 13 parts, Radix Ophiopogonis 13 parts, Fructus Schisandrae Chinensis 12 parts, Radix Glycyrrhizae Preparata 10 parts, Radix Scutellariae 20 parts, 13 parts of Radix Rubiae, 18 parts of the Radix Rehmanniae, Cacumen Platycladi 13 parts, 10 parts of Colla Corii Asini, Cortex Mori 13 parts, 12 parts of Semen Armeniacae Amarum, Cortex Lycii 12 parts, 10 parts of sea clam powder, Herba Artemisiae Annuae 10 parts, Cortex Moutan 10-20 part, Fructus Gardeniae 10-20 part, Rhizoma Imperatae 30 parts, Herba Agrimoniae 20 parts, Herba Ecliptae 20 parts, Radix Gentianae 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 11 parts, Radix Notoginseng powder 10 parts, Bulbus Fritillariae Cirrhosae 10 parts, Radix Angelicae Sinensis 10 parts, Nodus Nelumbinis Rhizomatis 20 parts, 13 parts of Folium Nelumbinis, Rhizoma Paridis 10 parts, Herba Scutellariae Barbatae 20 parts, Herba Lobeliae Chinensis 20 parts, Herba Hedyotidis Diffusae 20 parts, Herba Solani Nigri 20 parts, Radix Semiaquilegiae 15 parts and Herba Taraxaci 20 parts。
3. the Chinese medicine composition for the treatment of pulmonary carcinoma according to claim 2, cough, spitting of blood, it is characterised in that it also comprises the material of following weight portion: the material with following structural of 0.1 part:
。
4. the Chinese medicine composition for the treatment of pulmonary carcinoma according to claim 3, cough, spitting of blood, it is characterised in that described Chinese medicine composition can be lotion, ointment or powder。
5. the material with following structural treats the purposes in the medicine of pulmonary carcinoma, cough, spitting of blood in preparation:
。
CN201610107982.3A 2016-02-29 2016-02-29 Traditional Chinese medicine composition for treating lung cancer, cough and hemoptysis Pending CN105687839A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106237076A (en) * 2016-08-26 2016-12-21 余迎春 A kind of Chinese medicine formula treating pulmonary carcinoma and preparation method thereof
CN106621065A (en) * 2017-01-22 2017-05-10 贾庆国 Health-preserving back jacket
CN108686142A (en) * 2018-08-08 2018-10-23 赵友得 A kind of drug that treating lung cancer, preparation method and applications
CN114377088A (en) * 2020-10-22 2022-04-22 江苏省中医院 Traditional Chinese medicine composition for treating or preventing qi and yin deficiency of pulmonary diseases and preparation method and application thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103550718A (en) * 2013-11-18 2014-02-05 梁轶聪 Traditional Chinese medicine composition for treating lung cancer
CN104189859A (en) * 2014-09-23 2014-12-10 李玉富 Traditional Chinese medicine for treating lung cancer
CN105213911A (en) * 2015-10-30 2016-01-06 山东省立医院 A kind of Chinese medicine composition for the treatment of pulmonary carcinoma

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103550718A (en) * 2013-11-18 2014-02-05 梁轶聪 Traditional Chinese medicine composition for treating lung cancer
CN104189859A (en) * 2014-09-23 2014-12-10 李玉富 Traditional Chinese medicine for treating lung cancer
CN105213911A (en) * 2015-10-30 2016-01-06 山东省立医院 A kind of Chinese medicine composition for the treatment of pulmonary carcinoma

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106237076A (en) * 2016-08-26 2016-12-21 余迎春 A kind of Chinese medicine formula treating pulmonary carcinoma and preparation method thereof
CN106621065A (en) * 2017-01-22 2017-05-10 贾庆国 Health-preserving back jacket
CN108686142A (en) * 2018-08-08 2018-10-23 赵友得 A kind of drug that treating lung cancer, preparation method and applications
CN114377088A (en) * 2020-10-22 2022-04-22 江苏省中医院 Traditional Chinese medicine composition for treating or preventing qi and yin deficiency of pulmonary diseases and preparation method and application thereof

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