CN105617101A - Traditional Chinese medicine composition for treating lung cancer - Google Patents

Traditional Chinese medicine composition for treating lung cancer Download PDF

Info

Publication number
CN105617101A
CN105617101A CN201610094596.5A CN201610094596A CN105617101A CN 105617101 A CN105617101 A CN 105617101A CN 201610094596 A CN201610094596 A CN 201610094596A CN 105617101 A CN105617101 A CN 105617101A
Authority
CN
China
Prior art keywords
parts
herba
radix
chinese medicine
medicine composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610094596.5A
Other languages
Chinese (zh)
Inventor
席新进
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610094596.5A priority Critical patent/CN105617101A/en
Publication of CN105617101A publication Critical patent/CN105617101A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483—Gleditsia (locust)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/51—Gentianaceae (Gentian family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967—Lilium, e.g. tiger lily or Easter lily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to a traditional Chinese medicine composition for treating lung cancer.The traditional Chinese medicine composition is prepared from, by weight, 12 parts of bittersweet herb, 15 parts of herba ajugae, 10 parts of honeysuckle flowers, 15 parts of reed roots, 15 parts of whorlleaf stonecrop herb, 12 parts of tylophora fl ribunda, 10 parts of herba gerberae piloselloidis, 15 parts of lalang grass rhizomes, 10 parts of herba tripterospermi, 10 parts of herb of Ainsliaea fragrans champ, 12 parts of radix semiaquilegiae, 12 parts of herba houttuyniae, 10 parts of boat-fruited scaphium seeds, 10 parts of radix platycodi, 10 parts of cocklebur fruits, 12 parts of the root, stem and leaf of premna microphylla, 12 parts of radix ophiopogonis, 10 parts of the root of red-rooted salvia, 10 parts of rhizoma polygoni cuspidati, 12 parts of spina gleditsiae, 10 parts of herb of sharpfruit calanthodes, 12 parts of rhizoma acori graminei, 20 parts of radix asparagi, 10 parts of radix polygni multiflori, 12 parts of hemiboea subcapitata, 15 parts of whitebackleaf mallotus roots, 12 parts of lily flowers, 10 parts of Japanese thistle herb or roots and 12 parts of Nandina domestica Thunb.The medicine is safe and reliable, all the medicine materials are in proper portion, the effects of promoting dampness and phlegm elimination, tonifying the spleen and regulating qi and the like are achieved, and the traditional Chinese medicine composition has the advantages of being definite in curative effect, rapid in effect taking, high in cure rate, free of side effects and the like when treating the lung cancer.

Description

A kind of Chinese medicine composition treating pulmonary carcinoma
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of Chinese medicine composition treating pulmonary carcinoma.
Background technology
Pulmonary carcinoma is that M & M increases the soonest, one of malignant tumor maximum to population health and life threat. The many countries of immediate and mid-term all report that the M & M of pulmonary carcinoma all substantially increases, and male lung cancer M & M all accounts for first of all malignant tumor, and women sickness rate accounts for second, and mortality rate accounts for second. So far still not exclusively clearly, great mass of data shows the cause of disease of pulmonary carcinoma, and long-term a large amount of smokings have very close relationship with pulmonary carcinoma. Existing research proves: the probability that long-term a large amount of smokers suffer from pulmonary carcinoma is 10��20 times of non-smoker, and the age starting smoking is more little, and the probability suffering from pulmonary carcinoma is more high.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition treating pulmonary carcinoma.
In order to realize the purpose of the present invention, the present invention provides a kind of Chinese medicine composition treating pulmonary carcinoma, it comprises the material of following weight portion: Herba Solani Lyrati 12 parts, Herba Ajugae 15 parts, Flos Lonicerae 10 parts, root of phragmites communis 15 parts, Herba Hylothelephii Verticillati 15 parts, Radix tylophorae floribundae 12 parts, Herba Gerberae Piloselloidis 10 parts, Rhizoma Imperatae 15 parts, Herba Tripterospermi 10 parts, Fructus Pruni perfume (or spice) Herba Ainsliaeae Glabrae 10 parts, Radix Semiaquilegiae 12 parts, Herba Houttuyniae 12 parts, Semen Sterculiae Lychnophorae 10 parts, Radix Platycodonis 10 parts, Fructus Xanthii 10 parts, Herba Premnae Microphyllae 12 parts, Radix Ophiopogonis 12 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Polygoni Cuspidati 10 parts, Spina Gleditsiae 12 parts, Herba Calathodis Oxycarpae 10 parts, Rhizoma Acori Graminei 12 parts, Radix Asparagi 20 parts, purple 10 parts of rattan of crow, Herba Hemiboeae 12 parts, Folium Malloti Apeltae 15 parts, Bulbus Lilii 12 parts, Radix Cirsii Japonici 10 parts and Fructus Nandinae Domesticae 12 parts.
Preferably, the Chinese medicine composition for the treatment of pulmonary carcinoma of the present invention also comprises the material of following weight portion: the material with following structural of 0.1 part:
It is highly preferred that described Chinese medicine composition can be lotion, ointment or powder.
The present invention also provides for compound purposes in the medicine of preparation treatment pulmonary carcinoma, and this compound has having structure:
The present invention also provides for compound purposes in the medicine of preparation vitro inhibition human small cell lung carcinoma cell strain NCI-H446, and this compound has having structure:
The safety of medicine of present invention medicine phase reliable, all and, there is promotion drying dampness to eliminate phlegm, spleen invigorating and the effect such as regulate the flow of vital energy, the features such as treatment pulmonary carcinoma has determined curative effect, instant effect, cure rate is high, have no side effect.
Detailed description of the invention
Further illustrate the present invention by the examples below. It should be understood that embodiments of the invention are an illustration for the present invention rather than limitation of the present invention. The simple modifications that the present invention is carried out by the essence according to the present invention broadly falls into the scope of protection of present invention. Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment 1
Weigh Herba Solani Lyrati 12 grams, Herba Ajugae 15 grams, Flos Lonicerae 10 grams, root of phragmites communis 15 grams, Herba Hylothelephii Verticillati 15 grams, Radix tylophorae floribundae 12 grams, Herba Gerberae Piloselloidis 10 grams, Rhizoma Imperatae 15 grams, Herba Tripterospermi 10 grams, Fructus Pruni perfume (or spice) Herba Ainsliaeae Glabrae 10 grams, Radix Semiaquilegiae 12 grams, Herba Houttuyniae 12 grams, Semen Sterculiae Lychnophorae 10 grams, Radix Platycodonis 10 grams, Fructus Xanthii 10 grams, Herba Premnae Microphyllae 12 grams, Radix Ophiopogonis 12 grams, Radix Salviae Miltiorrhizae 10 grams, Rhizoma Polygoni Cuspidati 10 grams, Spina Gleditsiae 12 grams, Herba Calathodis Oxycarpae 10 grams, Rhizoma Acori Graminei 12 grams, Radix Asparagi 20 grams, purple 10 grams of rattan of crow, Herba Hemiboeae 12 grams, Folium Malloti Apeltae 15 grams, Bulbus Lilii 12 grams, Radix Cirsii Japonici 10 grams and Fructus Nandinae Domesticae 12 grams, pulverize, add 100000 milliliters of water, the heating 3 hours when backflow, filter, filtrate is made to be cooled to room temperature, then through the filtering with microporous membrane of 0.22 ��m, obtain solution 1.
Embodiment 2
Weigh 0.1 gramAdd 80000 ml sterile waters, ultrasonic 30 minutes, the then filtering with microporous membrane of 0.22 ��m, obtain solution 2.
Experimental example
MTT (available from Sigma) physiological saline solution, is configured to the working solution of 5mg/mL ,-20 DEG C of preservations; Dimethyl sulfoxide (DMSO) produces for Xi'an chemical reagent factory, analytical pure.
Mtt assay principle
MTT is that one can accept H+Weld. In living cells mitochondrial respiratory chain, succinate dehydrogenase and cytochrome C can make the tetrazole ring opening of MTT, generate hepatic formazan crystallization. And without this dehydrogenase in dead cell. The growing amount of Formazan crystallization is directly proportional to viable count, and the DMSO solution of this crystallization has maximum absorption band at 570nm place, so, the impact of medicine on cell proliferation can be evaluated by detecting the amount of formazan crystallization.
Method of testing
Take the logarithm the tumor cell of trophophase, cell density is adjusted to 2 �� 105Individual/mL, is added in 96 porocyte culture plates by every hole 200 �� L, passes into 5%CO in 37 DEG C2Incubator in cultivate 4h. Sample sets 5 Concentraton gradient respectively, and each concentration sets 3 Duplicate Samples, sets the positive, negative control simultaneously, and every hole adds sample liquid or each 2 �� L of blank solution, cultivating 72h, then every hole adds MTT liquid 10 �� L, continues to cultivate 4h, 37 DEG C, 2000r/min is centrifuged 8min, sucks supernatant. Every hole adds each 100 �� L of DMSO and vibrate on micro oscillator 15min, after being completely dissolved to crystallization, and the light absorption value (OD value) at microplate reader mensuration 570nm place, every hole. Take three hole mean OD value by IR%=(ODComparison-ODSample)/ODComparison�� 100% suppression ratio (IR%) calculating sample on cell proliferation.
Human small cell lung carcinoma cell strain NCI-H446, purchased from Bei Nuo bio tech ltd, Shanghai, adopts mtt assay, carries out anti tumor activity in vitro evaluation with amycin for positive control drug, and result is as follows:
Sample Concentration (��M) OD value Suppression ratio % 2-->
Blank group 1.12��0.05
Matched group 1.09��0.03
Amycin 0.5 0.26��0.01 76.15
Solution 1 50 0.38��0.01 65.14
Solution 2 50 0.30��0.01 72.48
For human small cell lung carcinoma cell strain NCI-H446, be there is In-vitro Inhibitory Effect from the above results, solution 1 and solution 2.

Claims (5)

1. the Chinese medicine composition treating pulmonary carcinoma, it is characterized in that, it comprises the material of following weight portion: Herba Solani Lyrati 12 parts, Herba Ajugae 15 parts, Flos Lonicerae 10 parts, root of phragmites communis 15 parts, Herba Hylothelephii Verticillati 15 parts, Radix tylophorae floribundae 12 parts, Herba Gerberae Piloselloidis 10 parts, Rhizoma Imperatae 15 parts, Herba Tripterospermi 10 parts, Fructus Pruni perfume (or spice) Herba Ainsliaeae Glabrae 10 parts, Radix Semiaquilegiae 12 parts, Herba Houttuyniae 12 parts, Semen Sterculiae Lychnophorae 10 parts, Radix Platycodonis 10 parts, Fructus Xanthii 10 parts, Herba Premnae Microphyllae 12 parts, Radix Ophiopogonis 12 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Polygoni Cuspidati 10 parts, Spina Gleditsiae 12 parts, Herba Calathodis Oxycarpae 10 parts, Rhizoma Acori Graminei 12 parts, Radix Asparagi 20 parts, purple 10 parts of rattan of crow, Herba Hemiboeae 12 parts, Folium Malloti Apeltae 15 parts, Bulbus Lilii 12 parts, Radix Cirsii Japonici 10 parts and Fructus Nandinae Domesticae 12 parts.
2. the Chinese medicine composition for the treatment of pulmonary carcinoma according to claim 1, it is characterised in that it also comprises the material of following weight portion: the material with following structural of 0.1 part:
3. the Chinese medicine composition for the treatment of pulmonary carcinoma according to claim 2, it is characterised in that described Chinese medicine composition can be lotion, ointment or powder.
4. compound purposes in the medicine of preparation treatment pulmonary carcinoma, it is characterised in that this compound has having structure:
5. compound purposes in the medicine of preparation vitro inhibition human small cell lung carcinoma cell strain NCI-H446, it is characterised in that this compound has having structure:
CN201610094596.5A 2016-02-22 2016-02-22 Traditional Chinese medicine composition for treating lung cancer Pending CN105617101A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610094596.5A CN105617101A (en) 2016-02-22 2016-02-22 Traditional Chinese medicine composition for treating lung cancer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610094596.5A CN105617101A (en) 2016-02-22 2016-02-22 Traditional Chinese medicine composition for treating lung cancer

Publications (1)

Publication Number Publication Date
CN105617101A true CN105617101A (en) 2016-06-01

Family

ID=56032708

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610094596.5A Pending CN105617101A (en) 2016-02-22 2016-02-22 Traditional Chinese medicine composition for treating lung cancer

Country Status (1)

Country Link
CN (1) CN105617101A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001131163A (en) * 1999-11-05 2001-05-15 Yamanouchi Pharmaceut Co Ltd Indenothiazol derivative
CN105267890A (en) * 2015-12-01 2016-01-27 青岛市肿瘤医院 Traditional Chinese medicine formula for treating lung cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001131163A (en) * 1999-11-05 2001-05-15 Yamanouchi Pharmaceut Co Ltd Indenothiazol derivative
CN105267890A (en) * 2015-12-01 2016-01-27 青岛市肿瘤医院 Traditional Chinese medicine formula for treating lung cancer

Similar Documents

Publication Publication Date Title
Van Wyk A review of Khoi-San and Cape Dutch medical ethnobotany
CN111150792A (en) Chinese medicinal composition with effect of resisting novel coronavirus SARS-Cov-2, and preparation method and application thereof
CN111569035B (en) Traditional Chinese medicine composition and application thereof in preparation of medicine for treating new coronary pneumonia, especially asymptomatic infected patients
CN105687839A (en) Traditional Chinese medicine composition for treating lung cancer, cough and hemoptysis
CN103385980A (en) Decoction for treating pneumonia
CN102836368A (en) Chinese medicine composite for treating bee diseases and preparation method thereof
CN102335373B (en) Chinese medicinal composition for treating upper respiratory tract infection, and preparation method thereof
CN102552509B (en) Traditional Chinese medicine combination for reducing heat and relieving cough
CN101716300B (en) Cough relief traditional Chinese medicine compound preparation and preparation method thereof
CN106943561A (en) It is a kind of that there is shield lung, anti-PM2.5 to injure herbal prescription of effect and preparation method thereof
CN105664052A (en) Traditional Chinese medicine composition for treating breast cancer, breast cyst, breast mass and breast pain
CN105748979A (en) Traditional Chinese medicine compound extract for resisting RSV (respiratory syncytial virus) virus as well as preparation method and application thereof
CN105617101A (en) Traditional Chinese medicine composition for treating lung cancer
CN101642501A (en) Medicine used for wind heat disease of cold for clearing away heat and toxic materials, dispelling wind and relieving exterior syndrome and preparation method thereof
CN101721614A (en) Pharmaceutical composition with effects of clearing throat, reducing swelling and alleviating pain
CN102198192B (en) Traditional Chinese medicine composition for treating HINI and application thereof
CN103417872A (en) TCM composition for treatment of lung cancer and preparation method thereof
CN105395941A (en) A heat clearing and detoxifying traditional Chinese medicine oral liquid
CN105535657A (en) Traditional Chinese medicine composition for treating colon cancer
CN105797092B (en) Yiyuan anti-cold mixture
CN103142954A (en) Medicine for treating asthma
CN107137619A (en) Anti-breast cancer health products containing Rice Bran Flavonoid
CN107158286A (en) It is a kind of to be used to treat Chinese medicine composition that haze causes respiratory tract injury to induce disease and preparation method thereof
CN105012391B (en) Medicine for treating viral influenza and preparation method thereof
CN105833190A (en) Traditional Chinese medicine composition for treating nasopharyngeal carcinoma

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20160601

RJ01 Rejection of invention patent application after publication