CN105687399A - Antipyretic Chinese herb composition including herba centellae and preparation of antipyretic Chinese herb composition including herba centellae - Google Patents
Antipyretic Chinese herb composition including herba centellae and preparation of antipyretic Chinese herb composition including herba centellae Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention discloses an antipyretic Chinese herb composition including herba centellae and a preparation of the antipyretic Chinese herb composition including herba centellae. The antipyretic Chinese herb composition is prepared from herba centellae, herba hedyotideae and triquetrous tadehagi herb at the ratio of (0.8-1.2):(0.8-1.2):( 0.8-1.2) by weight. The composition has the effects of clearing away heat and prompting diuresis, and relieving swelling and clearing away toxic materials, is used for antipyresis and is an oral medicine with a lasting medicine effect. In addition, according to the composition, geo-authentic crude medicine materials of the south of the Five ridges are adopted, raw materials are easy to obtain, and the extraction process of the effective ingredients of the medicine materials is easy and convenient to implement.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of containing Herba Centellae and for antipyretic Chinese medicine composition and its application in Chinese medicine preparation。
Background technology
Heating refer to pyrogen directly act on heat production that thermotaxic centre, heat center dysfunction or a variety of causes cause too much, heat radiation reduce, cause that body temperature increases to over the situation of normal range。When weather drastic change, inside and outside human body, function does not adapt to, and pathogen takes advantage of a weak point in opponent's defence to be entered by fur, mouth and nose, it is easy to causing a series of heating paresthesia, the four seasons all can occur, and infectiousness is relatively strong, is affect health of people and the most commonly seen a kind of disease of normal social life。Additionally, the teenager of under-18s, the child that Aspirin is likely to make to have a high fever breaks out Lei Shi syndrome, and this is a kind of fatefulue sacred disease。
Therefore, research and development have refrigeration function and the longer Chinese medicine fever allaying prepn of duration of efficacy, to extensive patients, particularly to adolescent patient, have great importance。
Summary of the invention
It is an object of the invention to provide a kind of for antipyretic containing Herba Centellae Chinese medicine composition, it derives from south of the Five Ridges Chinese herbal medicine, and the medicinal raw material related to is easy to get, and drug effect is comparatively mild and the persistent period is longer, it is possible to make up the shortcoming that chemical drugs duration of efficacy is shorter。
The object of the present invention is achieved like this: a kind of for antipyretic containing Herba Centellae Chinese medicine composition, its formula is composed of the following components: the weight ratio of Herba Centellae, Caulis et Folium hedyotis hedyotideae and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) is 0.8-1.2:0.8-1.2:0.8-1.2。
Preferably, formula is composed of the following components: the weight ratio of Herba Centellae, Caulis et Folium hedyotis hedyotideae and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) is 0.9-1.1:0.9-1.1:0.9-1.1。
Most preferred, formula is composed of the following components: the weight ratio of Herba Centellae, Caulis et Folium hedyotis hedyotideae and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) is 1:1:1。
Described Chinese medicine composition is decoction。
A kind of for antipyretic containing Herba Centellae Chinese medicine preparation, be that the extract of component is effective ingredient in described Traditional Chinese medicine composition formula, add the preparation that pharmaceutic adjuvant prepares。
The dosage form of described preparation is tablet, capsule, granule, oral liquid or drop pill。
Described extract is water extract。
The medicine of the present invention has the effect of clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating, is a kind of for antipyretic and that drug effect is comparatively lasting oral medicine。And the present invention adopts south of the Five Ridges genuine medicinal materials, raw material is easy to get, and the extraction process of effective ingredient is easy。
Accompanying drawing explanation
Fig. 1 is that dry yeast is caused rat fever Temperature changing situation comparison diagram by experimental example different pharmaceutical of the present invention。
Detailed description of the invention
The present invention be a kind of for antipyretic containing Herba Centellae Chinese medicine composition, its formula is composed of the following components: the weight ratio of Herba Centellae, Caulis et Folium hedyotis hedyotideae and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) is 0.8-1.2:0.8-1.2:0.8-1.2。Preferably, formula is composed of the following components: the weight ratio of Herba Centellae, Caulis et Folium hedyotis hedyotideae and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) is 0.9-1.1:0.9-1.1:0.9-1.1。Most preferred, formula is composed of the following components: the weight ratio of Herba Centellae, Caulis et Folium hedyotis hedyotideae and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) is 1:1:1。
Described Chinese medicine composition can be decoction。Or, the convenience taken for patient and the characteristic according to extract, it is possible to making preparation, in described Traditional Chinese medicine composition formula, the extract of component is for effective ingredient, adds corresponding pharmaceutic adjuvant, prepares into any oral formulations according to Chinese medicine conventional formulation technique。The dosage form of preparation can be tablet, capsule, granule, oral liquid or drop pill etc.。Wherein extract is preferably water extract, can prepare by extraction process by water routinely, such as: the medical material taking formula mixes according to monarch prescription ratio, every time by the water of 6～12 times of medical material deals, heating and refluxing extraction 1～3 hour, extract 1～3 time, filter, merging filtrate, is concentrated to every milliliter contained 1.0～5.0g, to obtain final product。Add corresponding pharmaceutic adjuvant to extract again and can prepare into any oral formulations。
In formula, Herba Centellae, have another name called and collapse jorum, for the herb of Umbelliferae Centella Herba Centellae Centellaasiatica (L.) Urban。Hardship, pungent, cold。Clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating, be used for catch a cold high heat, jaundice due to damp-heat, furuncle carbuncle poison, traumatic injury etc.。Shennong's Herbal: " main big heat, malignant boil, carbuncle, contamination, red, skin is red, fever of the body。"
Caulis et Folium hedyotis hedyotideae, for the dry root of Rubiaceae cerastium Caulis et Folium hedyotis hedyotideae Hedyotishedyotidea (DC.) Merr.。Sweet, light, cool。Clearing away summer-heat, dispelling, collateral-activating, reducing swelling and alleviating pain, for heatstroke, cold, fever, cough, vomiting and diarrhoea etc.。
Herba Desmodii Triquetri (Herba Tadehagi Triquetri), for the Herb of pulse family tadehagi ohashi Herba Desmodii Triquetri (Herba Tadehagi Triquetri) Tadehagitriquetrum (L.) Ohashi。Micro-hardship, puckery, cool。Heat-clearing and toxic substances removing, strengthening the spleen to promote digestion and diuresis, for heatstroke excessive thirst, cold, fever, laryngopharynx swelling and pain, pneumonopathy hemoptysis, nephritis, infantile malnutrition, jaundice, have loose bowels, dysentery, rheumatic arthritis etc.。
We, using Herba Centellae and Caulis et Folium hedyotis hedyotideae as the monarch and his subjects' medicine in prescription, play its clearing away heat-damp and promoting diuresis, the effect of subduing swelling and detoxicating, and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) is as the medicine that makes in prescription, after high heat while auxiliary temperature-reducing, play spleen invigorating, diuresis, strengthen metabolic condition in the patient。
The following example will be further illustrated the preparation method of the present invention and the present invention applies in Chinese medicine preparation, and all technology realized based on foregoing of the present invention belong to the scope of the present invention。Preferred embodiments 1。
Embodiment 1 takes Herba Centellae 108g, Caulis et Folium hedyotis hedyotideae 108g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 108g, shreds, and adds the water of 10 times of medical material weight, reflux, extract, 1.5 hours, extracts 2 times, united extraction liquid, filters, merging filtrate, is concentrated to 250ml, obtains decoction。
Embodiment 2 takes Herba Centellae 108g, Caulis et Folium hedyotis hedyotideae 108g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 108g, shreds, and adds the water of 12 times of medical material weight, reflux, extract, 3 hours, extracts 3 times, united extraction liquid, filters, merging filtrate, is concentrated to 250ml, obtains decoction。
Embodiment 3 takes Herba Centellae 108g, Caulis et Folium hedyotis hedyotideae 108g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 108g, shreds, and adds the water of 8 times of medical material weight, reflux, extract, 1 hour, extracts 1 time, united extraction liquid, filters, merging filtrate, is concentrated to 250ml, obtains decoction。
Embodiment 4 takes Herba Centellae 108g, Caulis et Folium hedyotis hedyotideae 108g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 108g, shreds, and adds the water of 10 times of medical material weight, reflux, extract, 2 hours, extracts 2 times, united extraction liquid, filters, merging filtrate, is concentrated to 250ml, obtains decoction。
Embodiment 5 takes Herba Centellae 108g, Caulis et Folium hedyotis hedyotideae 108g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 108g, shreds, and adds the water of 8 times of medical material weight, reflux, extract, 3 hours, extracts 1 time, united extraction liquid, filters, merging filtrate, is concentrated to 250ml, obtains decoction。
Embodiment 6 takes Herba Centellae 108g, Caulis et Folium hedyotis hedyotideae 108g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 108g, shreds, and adds the water of 12 times of medical material weight, reflux, extract, 1 hour, extracts 2 times, united extraction liquid, filters, merging filtrate, is concentrated to 250ml, obtains decoction。
Embodiment 7 takes Herba Centellae 97.2g, Caulis et Folium hedyotis hedyotideae 108g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 108g, and preparation method is with embodiment 1。
Embodiment 8 takes Herba Centellae 97.2g, Caulis et Folium hedyotis hedyotideae 97.2g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 108g, and preparation method is with embodiment 1。
Embodiment 9 takes Herba Centellae 118.8g, Caulis et Folium hedyotis hedyotideae 97.2g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 97.2g, and preparation method is with embodiment 1。
Embodiment 10 takes Herba Centellae 108g, Caulis et Folium hedyotis hedyotideae 86.4g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 97.2g, and preparation method is with embodiment 1。
Embodiment 11 takes Herba Centellae 129.6g, Caulis et Folium hedyotis hedyotideae 108g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 108g, and preparation method is with embodiment 1。
Embodiment 11 takes Herba Centellae 129.6g, Caulis et Folium hedyotis hedyotideae 129.6g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 108g, and preparation method is with embodiment 1。
Embodiment 13 takes above-described embodiment 1 gained decoction, adds suitable quantity of water, and agitating heating is boiled, boil 30 minutes, to be cooled to 30～40 DEG C time, add appropriate chitosan and potassium sorbate, be stirred to dissolve uniformly, filter, finally add pure water to adjust to 1000ml, filter, subpackage, sterilizing, obtains oral liquid。Every oral liquid 10ml。
Embodiment 14 takes above-described embodiment 1 gained decoction, concentration, dry, obtains dry extract；Take dry extract 17.5g, add appropriate propylene glycol, lecithin and soybean oil, vibromill ultra micro 20 minutes, make mixing, make soft capsule 100, obtain soft capsule。Every containing content 0.4g。
Embodiment 15 takes above-described embodiment 1 gained decoction, concentration, dry, obtains dry extract；Take dry extract 23.8g, be ground into fine powder, add appropriate medical starch and magnesium stearate, mix homogeneously, sieve, load capsule, make 100, obtain hard capsule。The tolerant heavy 0.3g of every intragranular。
Embodiment 16 takes above-described embodiment 1 gained decoction, concentration, dry, obtains dry extract；Take dry extract 17.6g, be ground into fine powder, add appropriate medical starch and micropowder silica gel, mixing, cross 14 mesh sieves and granulate, 65 DEG C dry, carry out granulate after 14 mesh sieves, be subsequently adding appropriate magnesium stearate, and mixing is pressed into 100, obtains tablet。Every tablet weight 0.3g。
Embodiment 17 takes above-described embodiment 1 gained decoction, concentration, dry, obtains dry extract；Take dry extract 12.0g, it is ground into fine powder, with appropriate calcium hydrogen phosphate, microcrystalline Cellulose, sucralose, polyvinylpolypyrrolidone and carboxymethyl starch sodium, mixing, 3% povidone solution is binding agent, crossing 14 mesh sieves to granulate, 65 DEG C dry, carry out granulate after 14 mesh sieves, it is subsequently adding appropriate magnesium stearate, mixing, is pressed into 100, obtains dispersible tablet。Dispersible tablet every 0.5g。
Embodiment 18 takes above-described embodiment 1 gained decoction, concentration, dry, obtains dry extract；Take dry extract 20.2g, be ground into fine powder, add appropriate dextrin and lactose, mixing, granulate, 65 DEG C dry, and cross 14 mesh sieves and carry out granulate, subpackage, prepare 100 bags, obtain granule。Often bag weight 5g。
Embodiment 19 takes above-described embodiment 1 gained decoction, concentration, dry, obtains dry extract；Take dry extract 18.7g, be ground into fine powder；Separately take appropriate Macrogol 4000 and add heat fusing, add above-mentioned dry extract, mixing, instill in the liquid paraffin of cooling, make drop pill, obtain drop pill。Every ball weight 0.4g。
Experimental example
Take above-described embodiment 1 gained decoction, continue to be condensed into 100ml, then be configured to high and low two dosage successively, carry out zoopery as Test Drug Dosages, prove the curative effect of the present invention with this。
Take rat 60, body weight 180～220g, survey anus temperature every day 1 time, continuous 2 days, make rat adapt to the operation of this thermometric。Morning on the same day was first surveyed animal basal body temperature in experiment, then 1ml/100g dorsal sc injection is pressed with dry yeast suspension, after 4h survey body temperature, according to body temperature after modeling balanced with the difference of basal body temperature be grouped, respectively blank group, model group, positive drug group, drug extract high and low dose group。Blank group, model control group: gavage normal saline (10ml/kg)；Medicine high and low dose: the test medicine medicinal liquid (10ml/kg) of the high and low concentration of gavage；Positive controls: gavage aspirin 0.2g/kg；Chinese patent medicine group: gavage multi-arch retaining structure solution 0.375g/kg。Measure the anus temperature of 0.5h, 1h, 2h, 3h, 4h after being administered respectively, the index being Temperature changing with the difference of different time surveyed anus temperature with each basis anus temperature。All experimental datas are used that SPSS23.0 statistical software processes。Counting index adoptsRepresenting, wherein result P < 0.05 has statistical significance。Analysis result is as follows:
Table 1 prescriptions of Chinese medicine extract dry yeast is caused rat fever impact (N=10)
Note: compare with model group: * P < 0.05, represents have statistical significance。
According to interpretation, it will thus be seen that compared with model group, blank group each time period is respectively provided with significant difference (P < 0.05), it was shown that sterilised yeast suspension causes the success of rat fever model；After modeling, animal keeps high-temperature situation；Compared with model group, decoction high dose group prepared by prescriptions of Chinese medicine has significant difference (P < 0.05) in 2h and the 4h the two time period, showing that this prescription high dose group rat to yeast pyrogenicity can play refrigeration function in 2h～4h, the effective drug duration pointing out this prescription drug is longer。
Claims (7)
1., for antipyretic containing a Herba Centellae Chinese medicine composition, its formula is composed of the following components: the weight ratio of Herba Centellae, Caulis et Folium hedyotis hedyotideae and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) is 0.8-1.2:0.8-1.2:0.8-1.2。
2. according to claim 1 for antipyretic containing Herba Centellae Chinese medicine composition, it is characterised in that: described formula is composed of the following components: the weight ratio of Herba Centellae, Caulis et Folium hedyotis hedyotideae and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) is 0.9-1.1:0.9-1.1:0.9-1.1。
3. according to claim 1 for antipyretic containing Herba Centellae Chinese medicine composition, it is characterised in that: described formula is composed of the following components: the weight ratio of Herba Centellae, Caulis et Folium hedyotis hedyotideae and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) is 1:1:1。
4. according to claim 1 for antipyretic containing Herba Centellae Chinese medicine composition, it is characterised in that: described Chinese medicine composition is decoction。
5., for antipyretic containing a Herba Centellae Chinese medicine preparation, it is that the extract of component, for effective ingredient, adds the preparation that pharmaceutic adjuvant prepares in Traditional Chinese medicine composition formula described in claim 1,2 or 3。
6. according to claim 5 for antipyretic containing Herba Centellae Chinese medicine preparation, it is characterised in that: the dosage form of described preparation is tablet, capsule, granule, oral liquid or drop pill。
7. according to claim 5 for antipyretic containing Herba Centellae Chinese medicine preparation, it is characterised in that: described extract is water extract。
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105076601A (en) * | 2015-07-17 | 2015-11-25 | 冯爱丽 | Herb tea with centella and preparation method of the herb tea with centella |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105076601A (en) * | 2015-07-17 | 2015-11-25 | 冯爱丽 | Herb tea with centella and preparation method of the herb tea with centella |
Non-Patent Citations (1)
| Title |
|---|
| 中山医学院革命委员会: "《农村常见病防治手册》", 31 May 1970, 广东人民出版社 * |
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Application publication date: 20160622 |