CN105687333A - Injection for treating epidemic cerebrospinal meningitis - Google Patents
Injection for treating epidemic cerebrospinal meningitis Download PDFInfo
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- CN105687333A CN105687333A CN201610159133.2A CN201610159133A CN105687333A CN 105687333 A CN105687333 A CN 105687333A CN 201610159133 A CN201610159133 A CN 201610159133A CN 105687333 A CN105687333 A CN 105687333A
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses injection for treating epidemic cerebrospinal meningitis, being prepared from the following raw material medicines in parts by weight: 1.2-2.0 parts of honeysuckle flower, 0.4-1.6 parts of cyrtomium rhizome, 0.5-1.2 parts of fructus forsythiae, 0.4-1.0 part of gossamer urocteae and 0.3-0.6 part of galinsoga parviflora. According to the injection, analytic demonstration is carried out according to the causes of the epidemic cerebrospinal meningitis, and a formula is developed by combining the symptoms of the disease; the formula has main effects of clearing away heat and toxic materials as well as diminishing inflammation and relieving pain, and is capable of inhibiting the activity of pathogenic bacteria in the body; the injection is remarkable in curative effect, and clinical tests prove that the effective rate of the product reaches 93.3%.
Description
Divisional application, original applying number 2014106536239, applying date 2014.11.18, the injection of title treatment epidemic encephalitis and preparation method。
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of injection treating epidemic encephalitis and preparation method thereof。
Background technology
Epidemic cerebrospinal meningitis is called for short epidemic encephalitis, is the purulent meningitis caused by meningococcus。Pathogenic bacterium are invaded blood circulation by nasopharynx part, form septicemia, are finally confined to meninges and membrane of spinal cord, form suppurative meninges pathological changes。Main clinical manifestation has the meningeal irritation signs such as heating, headache, vomiting, skin petechia and stiffness of the neck, and cerebrospinal fluid is suppurative change。Additionally, meningococcus can not be invaded meninges and is showed only as septicemia, wherein severe one can be fulminant type outbreak。Infect and also can betide upper and lower respiratory tract, joint, the position such as pericardium and eye。Primary disease is all over seeing countries in the world, in distributing or large and small popular, with child morbidity for height。The state of an illness of epidemic encephalitis is complicated and changeable, and weight differs, and generally can behave as three Clinical types, i.e. plain edition, fulminant type and chronic septicemia。Additionally, still there is atypical presentation person。1～7 day incubation period, it is generally 2～3 days。Primary disease has two types: plain edition and fulminant type, plain edition epidemic encephalitis evolution, can be divided into upper respiratory tract infection phase, septicemia phase and meningitis phase three phases, but be difficult to clinically divide。Sometimes the state of an illness terminates at the septicemia phase and occurs without meningitis, and the meningitis phase then has septicemia to exist simultaneously；Fulminant type: small number of patients onset is hurried, and patient's condition is dangerous, as rescued not in time, often even at getting final product threat to life in 6h in 24h。Epidemic encephalitis is infectious disease caused by the bacteria, uses a large amount of Antibiotics medicine emergence therapeutic during treatment, as injected substantial amounts of penicillin, cephalo-type antibiotics, ceftazidime。The state of an illness is not belonging to tight danger, adopts treatment by Chinese herbs, and effect is more stable, safer。The traditional Chinese medical science dialectical treatmert to this disease, has pathogenic wind toxic to violate exterior syndrome, lassitude, aversion to wind, grade fever, and headache, inappetence, photophobia, phonophobia, there are numbness, pruritus or worm row sense, light red tongue, white and thin fur, floating and tense pulse in former wound。Another is syndrome of liver wind stirring up internally: then frightened on hearing the news or tic, even hears the underwater sound, water breakthrough or talks about then throat spasm of drinking water, and dysphoria, hyperhidrosis sialorrhea, difficult defecation of urinating, red tongue tongue is white, stringy pulse。
Publication number CN101537135A(application number 200810102462.9) Chinese patent literature disclose a kind of Chinese medicine preparation treating epidemic encephalitis, by antelope gusset plate, Folium Mori, Bulbus Fritillariae Cirrhosae, the fresh Radix Rehmanniae, Ramulus Uncariae macrophyllae, Flos Chrysanthemi, Lignum Poria, Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Forsythiae, Rhizoma Phragmitis, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle the raw material such as eats and prepares。Publication number CN104001108A(application number 201410213008.6) Chinese patent literature disclose treatment epidemic cerebrospinal meningitis Chinese medicine oral liquid, its by Gypsum Fibrosum 30 parts, Cornu rhinocerotis 10 parts, Rhizoma Coptidis 5 parts, 10 parts of the Radix Rehmanniae, Radix Scutellariae 10 parts, Bulbus Allii Fistulosi 15 parts, Radix Scrophulariae 9 parts, Radix Curcumae 10 parts, Radix Panacis Quinquefolii 15 parts, Fructus Mume 10 parts, Concha Ostreae 20 parts, Cortex Phellodendri 10 parts prepare。Notification number CN103830523A(application number 201410082018.0) Chinese patent literature disclose treatment epidemic cerebrospinal meningitis Chinese medicine composition, its Central Plains medicine includes Radix Isatidis 10-15g, Radix Scutellariae 3-5g, Cortex Phellodendri 3-5g, Fructus Gardeniae 3-5g, Concha rapanae thomasianae 10-15g, Hirudo 1.5-3g, Corallium Japonicum Kishinouye 9-12g, Radix Glycyrrhizae 5-9g, Rhizoma Anemarrhenae 10-15 gram, Radix Saposhnikoviae 10-15g, Cortex Moutan 10-15 gram, Radix Ginseng Rubra 9-12g, Radix Angelicae Sinensis 9-12g, Rhizoma Atractylodis Macrocephalae 9-12g, Rhizoma Pinelliae 5-9g, Fructus Crataegi 25g, Caulis Akebiae 25g, Rhizoma Cimicifugae 25g, Cinnabaris 3-5g。
At present, this sick published formula negligible amounts of Chinese medicine, and it is mostly some prescriptions without clinical safety certification, report about the Chinese medicine injection for the treatment of epidemic encephalitis is substantially free of, therefore, traditional Chinese medical science formula about treatment epidemic encephalitis also needs further research, and the curative effects such as the vomiting of epidemic encephalitis appearance, heating are also awaited further raising。
Summary of the invention
For the defect of prior art, it is an object of the invention to provide a kind of injection for the treatment of epidemic encephalitis preparing simple, instant effect and preparation method thereof。This injection stable curative effect, and safe without toxic side effect。
The technical scheme is that
The injection for the treatment of epidemic encephalitis, is mainly prepared from by following bulk drugs, is weight portion: Flos Lonicerae 1.2-2.0, Rhizoma Osmundae 0.4-1.6, Fructus Forsythiae 0.5-1.2, Uroctea compatilis Koch. 0.4-1.0, Herba galinsogae parviflorae 0.3-0.6。
In preferred scheme, Flos Lonicerae 1.2-2.0, Rhizoma Osmundae 0.4-1.6, Fructus Forsythiae 0.5-1.2, Uroctea compatilis Koch. 0.4-1.0, Herba galinsogae parviflorae 0.3-0.6。
More preferably, Flos Lonicerae 1.2-2.0, Rhizoma Osmundae 0.4-1.6, Fructus Forsythiae 0.5-1.2, Uroctea compatilis Koch. 0.4-1.0, Herba galinsogae parviflorae 0.3-0.6。
The preparation method of the injection of described treatment epidemic encephalitis is:
(1) by Flos Lonicerae and Fructus Forsythiae decontamination, pulverize, be placed in vapor distillation device, add water distillation and extraction three times, collect distillate；
(2) slightly being soaked by Rhizoma Osmundae clear water, section, be then placed in together with rice in pot, constantly stir-fry medical material, and it is buff that slow fire is fried to rice, and Rhizoma Osmundae is smoked to yellow, takes the dish out of the pot, and sieve removes rice, dries in the air cool；
(3) take Uroctea compatilis Koch. decontamination, be placed in appropriate vessel, dry with slow fire, take out, cool；
(4) being placed in together with Herba galinsogae parviflorae in marmite by medical material obtained by step (2) (3), warm water impregnates 40-60 minute (preferred, warm water immersion 50 minutes), then big fire is boiled, and turns little fire and decocts 30-70 minute (preferred, to turn little fire and decoct 50 minutes), filter, collect filtrate, remaining filtering residue is watered, decoct 40 minutes, filter, collect filtrate, again filtering residue secondary is watered, decoct 30 minutes, filter, merge three filtrates；
(5) by step (4) gained filtrate reduced in volume to 1/2nd of original volume, by ethanol precipitation process three times, in first time solution, alcohol content is 70%, second time is 80%, third time 85%, all place 12h every time, filter, filtrate reduced in volume is to without alcohol taste, add the activated carbon of appropriate water for injection and 0.5%, heating in water bath 30 minutes, cool, cold preservation 24h, filter, add step (1) gained distillate, stir evenly, pH value is regulated with 5% sodium hydroxide solution, it is eventually adding the benzyl alcohol of liquor capacity 0.1%, filter, embedding, high pressure steam sterilization, obtain injection。
The injection of described treatment epidemic encephalitis, step (1) adds water and distills 5 times into medical material weight that add water for the first time, and second time is 4 times, and third time is 3 times。
The weight ratio of the injection of described treatment epidemic encephalitis, step (2) rice and medical material is 1:2。
The injection of described treatment epidemic encephalitis, step (4) heat that the water yield is medical material weight 5-8 times (preferred, the water yield of heating is 6-7 times of medical material weight, it is more preferable to, the water yield of heating is 6.5 times of medical material weight)。
The injection of described treatment epidemic encephalitis, step (5) bath temperature be 90-100 DEG C (preferred, bath temperature is 93-97 DEG C, it is more preferable to, bath temperature is 95 DEG C)。
The injection of described treatment epidemic encephalitis, step (5) regulate pH value to 6.5-7.5 (preferred, regulate pH value to 6.8-7.2, it is more preferable to, regulate pH value to 7.0)。
The pharmacology of the present invention main raw material of Chinese medicine used is as follows:
Flos Lonicerae: nature and flavor: sweet；Cold。Gui Jing: lung；Stomach warp。Effect: heat-clearing and toxic substances removing。Cure mainly: epidemic febrile disease is generated heat；Toxic-heat and blood stasis；Carbuncle furuncle；Sore throat and multi-infection disease。
Rhizoma Osmundae: base: for Dryopteridaceae plant dryopteris crassirhizoma, Athyriaceae plant lunathyrium acrostichoidesChing, ball Pteridiaceae plant Matteuccia strthiopteris, Osmundaceae plant osmund, the rhizome of Blechnaceae plant Blechnum orientale Linn., Brainea insignis, Rhizoma Osmundae etc.。Nature and flavor: bitter are cool。Gui Jing: enter liver, stomach warp。Function cures mainly: kill ascarid, silk ribbon, pinworm, heat clearing away, removing toxic substances, removing heat from blood, hemostasis。Control anemopyretic cold。Warm macule, spits blood, epistaxis, discharging fresh blood stool, dysentery, metrorrhagia, leukorrhagia, skin infection, hematuria, menorrhagia, and knife injury is hemorrhage, ascarid, rich worm, taeniasis, artificial abortion, postpartum hemorrhage。
Fructus Forsythiae: base: for the fruit of Oleaceae plants Fructus Forsythiae。Nature and flavor: bitter, are slightly cold。Gui Jing: return lung, the heart, small intestine meridian。Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens。For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warm people battalion, high hot excessive thirst, coma sends out speckle, the puckery pain of pyretic stranguria。
Uroctea compatilis Koch.: base: Uroctea compatilis Koch. section animal Uroctea compatilis Koch. worm。Nature and flavor: hardship salty, micro-, cool in nature。Gui Jing: lung, liver, large intestine channel。Function cures mainly: heat-clearing and toxic substances removing, hemostasis。For pharyngolaryngitis, tonsillitis, oral cavity, gingival ulcer, epistaxis and incised wound are hemorrhage。
Herba galinsogae parviflorae: base: for the herb of feverfew Herba galinsogae parviflorae。Nature and flavor: light are flat。Function cures mainly: hemostasis, antiinflammatory。Cure mainly tonsillitis, pharyngolaryngitis, acute icterohepatitis；Wound hemorrhage is controlled in external。
The injection scientific formula for the treatment of epidemic encephalitis provided by the invention, preparation is simple, and products obtained therefrom is safe and reliable。In addition, the excellent results of the present invention is also manifested by:
1, the present invention is analyzed demonstration from the cause of disease causing epidemic encephalitis, in conjunction with disease, develops and obtains formula；
2, this prescription is with heat-clearing and toxic substances removing, anti-inflammatory analgetic for primary efficacy；
3, the present invention is evident in efficacy, and clinical trial proves, products obtained therefrom effective percentage is up to 93.3%。
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this。
Embodiment 1 treats the injection of epidemic encephalitis, is mainly prepared from (every part takes 20g) by following bulk drugs: Flos Lonicerae 1.2 parts, Rhizoma Osmundae 0.4 part, Fructus Forsythiae 0.5 part, Uroctea compatilis Koch. 0.4 part, Herba galinsogae parviflorae 0.3 part。
The preparation method of the injection of above-mentioned treatment epidemic encephalitis is:
(1) by Flos Lonicerae and Fructus Forsythiae decontamination, pulverize, be placed in vapor distillation device, add water distillation and extraction three times, (add water into medical material weight 5 times for the first time, and second time is 4 times, and third time is 3 times), collect distillate；
(2) slightly being soaked by Rhizoma Osmundae clear water, section, be then placed in together with rice in pot, the weight ratio of rice and medical material is 1:2, and constantly stir-fry medical material, and it is buff that slow fire is fried to rice, and Rhizoma Osmundae is smoked to yellow, takes the dish out of the pot, and sieve removes rice, dries in the air cool；
(3) take Uroctea compatilis Koch. decontamination, be placed in appropriate vessel, dry with slow fire, take out, cool；
(4) being placed in together with Herba galinsogae parviflorae in marmite by medical material obtained by step (2) (3), add the warm water immersion 40 minutes of medical material weight 5 times, then big fire is boiled, turn little fire to decoct 30 minutes, filter, collect filtrate, remaining filtering residue is watered, decoct 40 minutes, filter, collect filtrate, again filtering residue secondary is watered, decoct 30 minutes, filter, merge three filtrates；
(5) by step (4) gained filtrate reduced in volume to 1/2nd of original volume, by ethanol precipitation process three times, in first time solution, alcohol content is 70%, second time is 80%, third time 85%, all place 12h every time, filter, filtrate reduced in volume is to without alcohol taste, inject the activated carbon with water and 0.5%, water-bath 90 DEG C, heat 30 minutes, cool, cold preservation 24h, filter, add step (1) gained distillate, stir evenly, pH value is regulated to 6.5 with 5% sodium hydroxide solution, it is eventually adding the benzyl alcohol of liquor capacity 0.1%, filter, embedding, high pressure steam sterilization, obtain injection。
Embodiment 2 treats the injection of epidemic encephalitis, is mainly prepared from (every part takes 10g) by following bulk drugs: Flos Lonicerae 2.0 parts, Rhizoma Osmundae 1.6 parts, Fructus Forsythiae 1.2 parts, Uroctea compatilis Koch. 1.0 parts, Herba galinsogae parviflorae 0.6 part。
The preparation method of the injection for the treatment of epidemic encephalitis is:
(1) by Flos Lonicerae and Fructus Forsythiae decontamination, pulverize, be placed in vapor distillation device, add water distillation and extraction three times, (add water into medical material weight 5 times for the first time, and second time is 4 times, and third time is 3 times), collect distillate；
(2) slightly being soaked by Rhizoma Osmundae clear water, section, be then placed in together with rice in pot, the weight ratio of rice and medical material is 1:2, and constantly stir-fry medical material, and it is buff that slow fire is fried to rice, and Rhizoma Osmundae is smoked to yellow, takes the dish out of the pot, and sieve removes rice, dries in the air cool；
(3) take Uroctea compatilis Koch. decontamination, be placed in appropriate vessel, dry with slow fire, take out, cool；
(4) being placed in together with Herba galinsogae parviflorae in marmite by medical material obtained by step (2) (3), add the warm water immersion 60 minutes of medical material weight 8 times, then big fire is boiled, turn little fire to decoct 70 minutes, filter, collect filtrate, remaining filtering residue is watered, decoct 40 minutes, filter, collect filtrate, again filtering residue secondary is watered, decoct 30 minutes, filter, merge three filtrates；
(5) by step (4) gained filtrate reduced in volume to 1/2nd of original volume, by ethanol precipitation process three times, in first time solution, alcohol content is 70%, second time is 80%, third time 85%, all place 12h every time, filter, filtrate reduced in volume is to without alcohol taste, inject the activated carbon with water and 0.5%, water-bath 100 DEG C, heat 30 minutes, cool, cold preservation 24h, filter, add step (1) gained distillate, stir evenly, pH value is regulated to 7.5 with 5% sodium hydroxide solution, it is eventually adding the benzyl alcohol of liquor capacity 0.1%, filter, embedding, high pressure steam sterilization, obtain injection。
Model case: xxx, man, 64 years old。This morning starts heating, headache without obvious inducement, and rear vomiting is injection, companion is slight shiver with cold, systemic pain。Patient has history of coronary heart disease, dare not arbitrarily medication, then arrive examination in hospital, time medical, body temperature 39.5 DEG C, body temperature raises without evident regularity, sanity, and luminous reflectance is sensitive, slight pharyngalgia, coughs, health other have no malaise symptoms, be diagnosed as epidemic encephalitis after further examination。
The injection of injection the present embodiment gained treatment epidemic encephalitis, each 3-5ml, every day 1 time, 7 days courses for the treatment of。Two days later, body temperature is down to normal range, and katzeniammer slows down in injection, and vomiting stops, and after continuing injection 5 days, the every reaction of patient is all good, without malaise symptoms, consolidates curative effect and continues again to have injected 3 days, and clinical symptoms is wholly absent, and does not recur in half a year。
Embodiment 3 treats the injection of epidemic encephalitis, is mainly prepared from (every part takes 30g) by following bulk drugs: Flos Lonicerae 1.4 parts, Rhizoma Osmundae 0.8 part, Fructus Forsythiae 0.7 part, Uroctea compatilis Koch. 0.6 part, Herba galinsogae parviflorae 0.4 part。
The preparation method of the injection for the treatment of epidemic encephalitis is:
(1) by Flos Lonicerae and Fructus Forsythiae decontamination, pulverize, be placed in vapor distillation device, add water distillation and extraction three times, (add water into medical material weight 5 times for the first time, and second time is 4 times, and third time is 3 times), collect distillate；
(2) slightly being soaked by Rhizoma Osmundae clear water, section, be then placed in together with rice in pot, the weight ratio of rice and medical material is 1:2, and constantly stir-fry medical material, and it is buff that slow fire is fried to rice, and Rhizoma Osmundae is smoked to yellow, takes the dish out of the pot, and sieve removes rice, dries in the air cool；
(3) take Uroctea compatilis Koch. decontamination, be placed in appropriate vessel, dry with slow fire, take out, cool；
(4) being placed in together with Herba galinsogae parviflorae in marmite by medical material obtained by step (2) (3), add the warm water immersion 40 minutes of medical material weight 6 times, then big fire is boiled, turn little fire to decoct 30 minutes, filter, collect filtrate, remaining filtering residue is watered, decoct 40 minutes, filter, collect filtrate, again filtering residue secondary is watered, decoct 30 minutes, filter, merge three filtrates；
(5) by step (4) gained filtrate reduced in volume to 1/2nd of original volume, by ethanol precipitation process three times, in first time solution, alcohol content is 70%, second time is 80%, third time 85%, all place 12h every time, filter, filtrate reduced in volume is to without alcohol taste, inject the activated carbon with water and 0.5%, water-bath 93 DEG C, heat 30 minutes, cool, cold preservation 24h, filter, add step (1) gained distillate, stir evenly, pH value is regulated to 6.8 with 5% sodium hydroxide solution, it is eventually adding the benzyl alcohol of liquor capacity 0.1%, filter, embedding, high pressure steam sterilization, obtain injection。
Model case: xxx, man, 3 years old。Before two days, infant starts without obvious inducement to occur crying and screaming afternoon, father and mother find that its high heat is with shiver with cold, after start vomiting, then go to see a doctor, body temperature 39.9 DEG C time medical, infant has a dull expression on one's face, skin of lower extremity mucosa has dark or aubergine petechia ecchymosis, being diagnosed as plain edition epidemic encephalitis through hospital diagnosis inspection, hospital adopts western medical treatment, within 3 days, has no improvement。
Recommend to adopt the injection of the present embodiment gained treatment epidemic encephalitis by people, adopt once a day, each 3-5ml, 7 days courses for the treatment of。After injecting 3 days, infant body temperature is normal, and spirit is improved, and stops vomiting, continues injection 5 days, and all malaise symptoms all disappear, and petechia ecchymosis is thin out not easily just to be seen, continues to strengthen treatment 4 days, and infant clinical symptoms is wholly absent, and does not recur so far。
Embodiment 4 treats the injection of epidemic encephalitis, is mainly prepared from (every part takes 30g) by following bulk drugs: Flos Lonicerae 1.8 parts, Rhizoma Osmundae 1.2 parts, Fructus Forsythiae 1.0 parts, Uroctea compatilis Koch. 0.8 part, Herba galinsogae parviflorae 0.5 part。
The preparation method of the injection for the treatment of epidemic encephalitis is:
(1) by Flos Lonicerae and Fructus Forsythiae decontamination, pulverize, be placed in vapor distillation device, add water distillation and extraction three times, (add water into medical material weight 5 times for the first time, and second time is 4 times, and third time is 3 times), collect distillate；
(2) slightly being soaked by Rhizoma Osmundae clear water, section, be then placed in together with rice in pot, the weight ratio of rice and medical material is 1:2, and constantly stir-fry medical material, and it is buff that slow fire is fried to rice, and Rhizoma Osmundae is smoked to yellow, takes the dish out of the pot, and sieve removes rice, dries in the air cool；
(3) take Uroctea compatilis Koch. decontamination, be placed in appropriate vessel, dry with slow fire, take out, cool；
(4) being placed in together with Herba galinsogae parviflorae in marmite by medical material obtained by step (2) (3), add the warm water immersion 60 minutes of medical material weight 7 times, then big fire is boiled, turn little fire to decoct 70 minutes, filter, collect filtrate, remaining filtering residue is watered, decoct 40 minutes, filter, collect filtrate, again filtering residue secondary is watered, decoct 30 minutes, filter, merge three filtrates；
(5) by step (4) gained filtrate reduced in volume to 1/2nd of original volume, by ethanol precipitation process three times, in first time solution, alcohol content is 70%, second time is 80%, third time 85%, all place 12h every time, filter, filtrate reduced in volume is to without alcohol taste, inject the activated carbon with water and 0.5%, water-bath 97 DEG C, heat 30 minutes, cool, cold preservation 24h, filter, add step (1) gained distillate, stir evenly, pH value is regulated to 7.2 with 5% sodium hydroxide solution, it is eventually adding the benzyl alcohol of liquor capacity 0.1%, filter, embedding, high pressure steam sterilization, obtain injection。
Embodiment 5 treats the injection of epidemic encephalitis, is mainly prepared from (every part takes 20g) by following bulk drugs: Flos Lonicerae 1.6 parts, Rhizoma Osmundae 1.0 parts, Fructus Forsythiae 0.85 part, Uroctea compatilis Koch. 0.7 part, Herba galinsogae parviflorae 0.45 part。
The preparation method of the injection for the treatment of epidemic encephalitis is:
(1) by Flos Lonicerae and Fructus Forsythiae decontamination, pulverize, be placed in vapor distillation device, add water distillation and extraction three times, (add water into medical material weight 5 times for the first time, and second time is 4 times, and third time is 3 times), collect distillate；
(2) slightly being soaked by Rhizoma Osmundae clear water, section, be then placed in together with rice in pot, the weight ratio of rice and medical material is 1:2, and constantly stir-fry medical material, and it is buff that slow fire is fried to rice, and Rhizoma Osmundae is smoked to yellow, takes the dish out of the pot, and sieve removes rice, dries in the air cool；
(3) take Uroctea compatilis Koch. decontamination, be placed in appropriate vessel, dry with slow fire, take out, cool；
(4) being placed in together with Herba galinsogae parviflorae in marmite by medical material obtained by step (2) (3), add the warm water immersion 50 minutes of medical material weight 6.5 times, then big fire is boiled, turn little fire to decoct 50 minutes, filter, collect filtrate, remaining filtering residue is watered, decoct 40 minutes, filter, collect filtrate, again filtering residue secondary is watered, decoct 30 minutes, filter, merge three filtrates；
(5) by step (4) gained filtrate reduced in volume to 1/2nd of original volume, by ethanol precipitation process three times, in first time solution, alcohol content is 70%, second time is 80%, third time 85%, all place 12h every time, filter, filtrate reduced in volume is to without alcohol taste, inject the activated carbon with water and 0.5%, water-bath 95 DEG C, heat 30 minutes, cool, cold preservation 24h, filter, add step (1) gained distillate, stir evenly, pH value is regulated to 7.0 with 5% sodium hydroxide solution, it is eventually adding the benzyl alcohol of liquor capacity 0.1%, filter, embedding, high pressure steam sterilization, obtain injection。
The clinical practice of injection of test example 1 embodiment 5 gained treatment epidemic cerebrospinal meningitis: in February, 2012 in December ,-2013, the 264 common epidemic cerebrospinal meningitis out-patients of example are screened in 4 hospitals, wherein women 128 example, male 136 example, oldest 21 years old, minimal ages 1 years old, 10.7 years old mean age。Diagnostic criteria: how (1) falls ill at spring and summer and early autumn, often has virus infection history。(2) there is heating, headache, vomiting, diarrhoea, disturbance of consciousness, even the symptoms such as convulsions stupor。Infant bregma is full。(3) meningeal irritation sign is positive, sometimes can draw pathologic reflex。(4) cerebrospinal fluid outward appearance is limpid or micro-muddy, and pressure slightly increases, and cell number is mostly between 10～500/mm3, and lymphocyte occupies the majority。Albumen slightly increases, and sugar and chloride are normal。Minority case cerebrospinal fluid is without obvious change。The person of having ready conditions can make virus purification and Serological testing。(5) electroencephalogram: diffused inactive echoes often occurs。
Patient is randomly divided into two groups, experimental group 164 example and matched group 100 example, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability。Experimental group takes embodiment 5 products obtained therefrom, and every day injects once, and intramuscular injection, each 3-5m1(adjusts to some extent depending on concrete condition), 7 days courses for the treatment of, matched group injects other medicine conventional medication such as () sulfadiazine, benzylpenicillin, ampicillin。During taking medicine, two groups of patients are carried out Continuous Observation, record symptom and change。
Curative effect situation criterion: cure: clinical symptoms all disappears, health physical and chemical index inspection is normal, observes and has no repeatedly for three months；Effective: clinical symptom relief, the state of an illness is controlled, and health physical and chemical index inspection improves or normal；Invalid: clinical symptoms is without being clearly better or increasing the weight of。
Therapeutic outcome: the experimental group patient of the injection of injection embodiment 5 gained treatment epidemic encephalitis, cures 102(62.2%), effective 51(31.1%), invalid 11(6.7%), the total effective rate of experimental group is 93.3%, the healing of matched group and effective number of cases respectively 54 examples and 33 examples, and total effective rate is 87%。Experimental group is relatively better than matched group therapeutic effect, and during treatment, untoward reaction does not occur in experimental group patient, and matched group has small number of patients that medicament is occurred slight untoward reaction, it is seen that the more common Western medicine of experimental group injection is safer。
In the present invention, Flos Lonicerae and Rhizoma Osmundae have heat-clearing and toxic substances removing, cooling blood for hemostasis effect；Fructus Forsythiae has dispersing swelling and dissipating binds, dispelling wind and heat pathogens effect；Uroctea compatilis Koch. has heat-clearing and toxic substances removing, anastalsis；Herba galinsogae parviflorae has hemostasis and anti-inflammation effect, several raw material of Chinese medicine combineds effect, plays heat-clearing and toxic substances removing, anti-inflammatory analgetic effect, pathogen in purged body altogether, strengthens body immunity。
It should be pointed out that, the detailed description of the invention more representational example that is the present invention, it is clear that technical scheme is not limited to above-described embodiment, it is also possible to have many variations。Those of ordinary skill in the art, with the present invention undoubted the obtaining of clearly disclosed or according to file written description, be all considered as this patent scope of the claimed。
Claims (7)
1. treat the injection of epidemic encephalitis, it is characterised in that be mainly prepared from by following bulk drugs, be weight portion: Flos Lonicerae 1.8, Rhizoma Osmundae 1.2, Fructus Forsythiae 1.0, Uroctea compatilis Koch. 0.8, Herba galinsogae parviflorae 0.5。
2. the preparation method of the injection treating epidemic encephalitis as claimed in claim 1, it is characterised in that step is:
(1) by Flos Lonicerae and Fructus Forsythiae decontamination, pulverize, be placed in vapor distillation device, add water distillation and extraction three times, collect distillate；
(2) slightly being soaked by Rhizoma Osmundae clear water, section, be then placed in together with rice in pot, constantly stir-fry medical material, and it is buff that slow fire is fried to rice, and Rhizoma Osmundae is smoked to yellow, takes the dish out of the pot, and sieve removes rice, dries in the air cool；
(3) take Uroctea compatilis Koch. decontamination, be placed in appropriate vessel, dry with slow fire, take out, cool；
(4) being placed in together with Herba galinsogae parviflorae in marmite by medical material obtained by step (2) (3), warm water impregnates 40-60 minute (preferred, warm water immersion 50 minutes), then big fire is boiled, and turns little fire and decocts 30-70 minute (preferred, to turn little fire and decoct 50 minutes), filter, collect filtrate, remaining filtering residue is watered, decoct 40 minutes, filter, collect filtrate, again filtering residue secondary is watered, decoct 30 minutes, filter, merge three filtrates；
(5) by step (4) gained filtrate reduced in volume to 1/2nd of original volume, by ethanol precipitation process three times, in first time solution, alcohol content is 70%, second time is 80%, third time 85%, all place 12h every time, filter, filtrate reduced in volume is to without alcohol taste, inject the activated carbon with water and 0.5%, heating in water bath stirs 30 minutes, cool, cold preservation 24h, filter, add step (1) gained distillate, stir evenly, pH value is regulated with 5% sodium hydroxide solution, it is eventually adding the benzyl alcohol of liquor capacity 0.1%, filter, embedding, high pressure steam sterilization, obtain injection。
3. the injection treating epidemic encephalitis as claimed in claim 2, it is characterised in that step (1) adds water and distills 5 times into medical material weight that add water for the first time, and second time is 4 times, and third time is 3 times。
4. the injection treating epidemic encephalitis as claimed in claim 2, it is characterised in that the weight ratio of step (2) rice and medical material is 1:2。
5. the as claimed in claim 2 injection treating epidemic encephalitis, it is characterised in that step (4) heat that the water yield is medical material weight 5-8 times (preferably, the water yield of heating is 6-7 times of medical material weight, it is more preferable to, the water yield of heating is 6.5 times of medical material weight)。
6. the as claimed in claim 2 injection treating epidemic encephalitis, it is characterised in that step (5) bath temperature be 90-100 DEG C (preferred, bath temperature is 93-97 DEG C, it is more preferable to, bath temperature is 95 DEG C)。
7. the as claimed in claim 2 injection treating epidemic encephalitis, it is characterised in that step (5) regulate pH value to 6.5-7.5 (preferred, regulate pH value to 6.8-7.2, it is more preferable to, regulate pH value to 7.0)。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610159133.2A CN105687333A (en) | 2014-11-18 | 2014-11-18 | Injection for treating epidemic cerebrospinal meningitis |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610159133.2A CN105687333A (en) | 2014-11-18 | 2014-11-18 | Injection for treating epidemic cerebrospinal meningitis |
| CN201410653623.9A CN104352571B (en) | 2014-11-18 | 2014-11-18 | The injection for the treatment of epidemic encephalitis and preparation method |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410653623.9A Division CN104352571B (en) | 2014-11-18 | 2014-11-18 | The injection for the treatment of epidemic encephalitis and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105687333A true CN105687333A (en) | 2016-06-22 |
Family
ID=52519944
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610159133.2A Withdrawn CN105687333A (en) | 2014-11-18 | 2014-11-18 | Injection for treating epidemic cerebrospinal meningitis |
| CN201410653623.9A Active CN104352571B (en) | 2014-11-18 | 2014-11-18 | The injection for the treatment of epidemic encephalitis and preparation method |
| CN201610159132.8A Withdrawn CN105687332A (en) | 2014-11-18 | 2014-11-18 | Injection for treating epidemic cerebrospinal meningitis |
| CN201610159136.6A Withdrawn CN105687334A (en) | 2014-11-18 | 2014-11-18 | Injection capable of treating epidemic cerebrospinal meningitis and preparation method thereof |
| CN201610159135.1A Withdrawn CN105616518A (en) | 2014-11-18 | 2014-11-18 | Injection for treating epidemic cerebrospinal meningitis |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410653623.9A Active CN104352571B (en) | 2014-11-18 | 2014-11-18 | The injection for the treatment of epidemic encephalitis and preparation method |
| CN201610159132.8A Withdrawn CN105687332A (en) | 2014-11-18 | 2014-11-18 | Injection for treating epidemic cerebrospinal meningitis |
| CN201610159136.6A Withdrawn CN105687334A (en) | 2014-11-18 | 2014-11-18 | Injection capable of treating epidemic cerebrospinal meningitis and preparation method thereof |
| CN201610159135.1A Withdrawn CN105616518A (en) | 2014-11-18 | 2014-11-18 | Injection for treating epidemic cerebrospinal meningitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (5) | CN105687333A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830523A (en) * | 2014-03-07 | 2014-06-04 | 王玉芳 | Traditional Chinese medicine composition for treating epidemic cerebrospinal meningitis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102119994B (en) * | 2010-01-12 | 2012-05-23 | 冯陆冰 | Traditional Chinese medicine enema for treating exogenous fever of infants |
| CN104523863B (en) * | 2014-12-03 | 2019-03-01 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of traditional Chinese medicine infusion solution and its preparation method and application |
-
2014
- 2014-11-18 CN CN201610159133.2A patent/CN105687333A/en not_active Withdrawn
- 2014-11-18 CN CN201410653623.9A patent/CN104352571B/en active Active
- 2014-11-18 CN CN201610159132.8A patent/CN105687332A/en not_active Withdrawn
- 2014-11-18 CN CN201610159136.6A patent/CN105687334A/en not_active Withdrawn
- 2014-11-18 CN CN201610159135.1A patent/CN105616518A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830523A (en) * | 2014-03-07 | 2014-06-04 | 王玉芳 | Traditional Chinese medicine composition for treating epidemic cerebrospinal meningitis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104352571A (en) | 2015-02-18 |
| CN105687332A (en) | 2016-06-22 |
| CN105687334A (en) | 2016-06-22 |
| CN104352571B (en) | 2016-08-10 |
| CN105616518A (en) | 2016-06-01 |
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Address after: Beijing District of Gansu province Ludongming 730900 Baiyin District No. 4 1-502 Applicant after: Hao Jianyou Address before: Huaiyin District of Ji'nan City, Shandong province 250000 Ji Qi Road No. 112 Applicant before: Hao Jianyou |
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Application publication date: 20160622 |