CN105616518A - Injection for treating epidemic cerebrospinal meningitis - Google Patents

Injection for treating epidemic cerebrospinal meningitis Download PDF

Info

Publication number
CN105616518A
CN105616518A CN201610159135.1A CN201610159135A CN105616518A CN 105616518 A CN105616518 A CN 105616518A CN 201610159135 A CN201610159135 A CN 201610159135A CN 105616518 A CN105616518 A CN 105616518A
Authority
CN
China
Prior art keywords
filter
injection liquid
medicinal material
treatment
time
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201610159135.1A
Other languages
Chinese (zh)
Inventor
不公告发明人
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CN105616518A publication Critical patent/CN105616518A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Insects & Arthropods (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses injection for treating epidemic cerebrospinal meningitis. The injection is mainly prepared from the following active pharmaceutical ingredients by weight: 1.2 to 2.0 parts of honeysuckle, 0.4 to 1.6 parts of cyrtomium fortunei, 0.5 to 1.2 parts of fructus forsythiae, 0.4 to 1.0 part of uroctea, and 0.3 to 0.6 part of herb of smallflower galinsoga. The formula of the injection is obtained via analytic demonstration of pathogenesis of epidemic cerebrospinal meningitis, combination of symptoms and development; the main efficacies of the injection are clearing heat to remove toxicity and diminishing inflammation to relieve pain, and can inhibit the activity of pathogenic fungi in a body. The injection is obvious in curative effect; clinical tests show that the effective rate of obtained products can reach up to 93.3 percent.

Description

It is used for the treatment of the injection liquid of epidemic meningitis
Divide case application, original applying number 2014106536239, applying date 2014.11.18, the injection liquid of title treatment epidemic meningitis and preparation method.
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of injection liquid and its preparation method for the treatment of epidemic meningitis.
Background technology
Meningococcal meningitis is called for short epidemic meningitis, is the purulent meningitis caused by meningococcus. Pathogenic bacterium invade circulation of blood by pharynx nasalis, form septicemia, are finally confined to meninx and spinal cord film, form suppurative meninges pathology. Main clinical manifestation has heating, and the meninxes such as headache, vomiting, skin petechia and stiffness of the neck stimulate to be levied, and cerebrospinal fluid is suppurative change. In addition, meningococcus can not be invaded meninx and only be shown as septicemia, and wherein severe one can the outbreak in fulminant type. Infecting also to occur in upper and lower respiratory tract, joint, the position such as pericardium and eye. This disease all over seeing countries in the world, in distributing or large and small popular, take child morbidity as height. The state of an illness of epidemic meningitis is complicated and changeable, and weight differs, and generally can show as three Clinical types, i.e. coventional type, fulminant type and chronic septicemia. In addition, still there is atypical presentation person. In 1��7 day latent period, it is generally 2��3 days. This disease has two types: coventional type and fulminant type, coventional type epidemic meningitis development process, upper respiratory tract infection phase, septicemia phase and meningitis phase three phases can be divided into, but clinical on be difficult to divide. Sometimes the state of an illness terminates occurring in the septicemia phase without meningitis, and the meningitis phase then has septicemia to exist simultaneously; Fulminant type: it is hurried that small number of patients plays disease, patient's condition is dangerous, as rescued not in time, often even can jeopardize life in 24h in 6h. Epidemic meningitis is transmissible disease caused by the bacteria, uses a large amount of Antibiotics medicine emergence therapeutic during treatment, as injected a large amount of penicillin, cephalosporin antibiotic, ceftazidime. The state of an illness does not belong to tight danger, adopts treatment by Chinese herbs, and effect is more stable, safer. The traditional Chinese medical science, to the dialectical treatmert of this disease, has wind drug-pedlar's illness that has not attacked the vital organs of the human body, lassitude, dislikes wind, grade fever, headache, and poor appetite, photophobia, fear sound, there are numbness, itch or worm row sense in former wound, light red tongue, white and thin fur, floating and tense pulse. Another is liver-wind stirring up internally card: then frightened on hearing the news or tic, even hears the underwater sound, water breakthrough or talks about then throat spasm of drinking water, haves the fidgets, and hidrosis salivates, difficult defecation of urinating, and the red tongue of tongue is white, arteries and veins string.
Publication number CN101537135A(application number 200810102462.9) Chinese patent literature disclose a kind of Chinese medicine preparation treating epidemic meningitis, by antelope gusset plate, Folium Mori, capital tendril-leaved fritillary bulb, the fresh dried rhizome of rehmannia, Ramulus Uncariae macrophyllae, chrysanthemum, pine among the Tuckahoe, grow radix paeoniae alba, Radix Glycyrrhizae, the capsule of weeping forsythia, reed rhizome, henon bamboo the raw material such as eats and obtains. Publication number CN104001108A(application number 201410213008.6) Chinese patent literature disclose treatment meningococcal meningitis traditional Chinese medicine oral liquid, its by plaster stone 30 parts, rhinoceros horn 10 parts, the coptis 5 parts, 10 parts, the dried rhizome of rehmannia, the root of large-flowered skullcap 10 parts, Bulbus Allii Fistulosi 15 parts, radix scrophulariae 9 parts, root tuber of aromatic turmeric 10 parts, Radix Panacis Quinquefolii 15 parts, dark plum 10 parts, oyster 20 parts, golden cypress 10 parts obtain. Notification number CN103830523A(application number 201410082018.0) Chinese patent literature disclose treatment meningococcal meningitis Chinese medicine composition, Root of Indigowoad 10-15g drawn together by its Central Plains cartridge bag, root of large-flowered skullcap 3-5g, golden cypress 3-5g, cape jasmine 3-5g, Concha rapanae thomasianae 10-15g, leech 1.5-3g, coral 9-12g, Radix Glycyrrhizae 5-9g, wind-weed 10-15 gram, windproof 10-15g, Tree Peony Bark 10-15 gram, red ginseng 9-12g, Radix Angelicae Sinensis 9-12g, bighead atractylodes rhizome 9-12g, tuber of pinellia 5-9g, hawthorn 25g, akebi 25g, rattletop 25g, cinnabar 3-5g.
At present, this sick published formula comparatively small amt of Chinese medicine, and it is mostly some prescriptions without clinical safety certification, report about the traditional Chinese medicine injection for the treatment of epidemic meningitis does not have substantially, therefore, traditional Chinese medical science formula about treatment epidemic meningitis also needs further research, and the vomiting, the curative effect such as heating that epidemic meningitis are occurred also await further raising.
Summary of the invention
For the defect of prior art, it is an object of the invention to provide the injection liquid of a kind for the treatment of epidemic meningitis preparing simple, instant effect and its preparation method. This injection liquid stable curative effect, and safe without toxic side effect.
The technical scheme of the present invention is:
The injection liquid for the treatment of epidemic meningitis, is prepared from primarily of following bulk drugs, is weight part: Japanese Honeysuckle 1.2-2.0, rhizome of cyrtomium 0.4-1.6, capsule of weeping forsythia 0.5-1.2, wall money 0.4-1.0, Herba galinsogae parviflorae 0.3-0.6.
In preferred scheme, Japanese Honeysuckle 1.2-2.0, rhizome of cyrtomium 0.4-1.6, capsule of weeping forsythia 0.5-1.2, wall money 0.4-1.0, Herba galinsogae parviflorae 0.3-0.6.
More preferably, Japanese Honeysuckle 1.2-2.0, rhizome of cyrtomium 0.4-1.6, capsule of weeping forsythia 0.5-1.2, wall money 0.4-1.0, Herba galinsogae parviflorae 0.3-0.6.
The preparation method of the injection liquid of described treatment epidemic meningitis is:
(1) by Japanese Honeysuckle and capsule of weeping forsythia decon, pulverize, it is placed in wet distillation device, adds water distillation and extraction three times, collect distillate;
(2) slightly being soaked by rhizome of cyrtomium clear water, section, is then placed in pot together with rice, constantly turns over stir-fry medicinal material, and it is deep yellow that slow fire is fried to rice, and rhizome of cyrtomium is smoked to yellow, goes out pot, and sieve removes rice, dries in the air cool;
(3) get wall money decon, it is placed in appropriate vessel, dries with slow fire, take out, cool;
(4) medicinal material obtained by step (2) (3) is placed in marmite together with Herba galinsogae parviflorae, warm water dipping 40-60 minute (preferred, warm water immersion 50 minutes), then big fire is boiled, and turns little fire and decocts 30-70 minute (preferred, to turn little fire and decoct 50 minutes), filter, collect filtrate, remaining filter residue is watered, decoct and boil 40 minutes, filter, collect filtrate, again filter residue is watered for two times, decoct and boil 30 minutes, filter, merge three filtrates;
(5) step (4) gained filtrate decompression is concentrated 1/2nd to original volume, three times are processed with alcohol settling, in solution, alcohol content is 70% for the first time, second time is 80%, third time 85%, all place 12h every time, filter, filtrate decompression concentrates to without alcohol taste, add the gac of appropriate water for injection and 0.5%, heating in water bath 30 minutes, cool, refrigeration 24h, filter, add step (1) gained distillate, stir even, by 5% sodium hydroxide solution adjust ph, finally add the phenylcarbinol of liquor capacity 0.1%, filter, embedding, high pressure steam sterilization, obtain injection liquid.
The injection liquid of described treatment epidemic meningitis, step (1) adds water and distills 5 times into medicinal material weight that add water for the first time, and second time is 4 times, and third time is 3 times.
The injection liquid of described treatment epidemic meningitis, the weight ratio of step (2) rice and medicinal material is 1:2.
The injection liquid of described treatment epidemic meningitis, step (4) heat the water yield be medicinal material weight 5-8 doubly (preferred, the water yield of heating be medicinal material weight 6-7 doubly, more preferably, the water yield of heating is 6.5 times of medicinal material weight).
The injection liquid of described treatment epidemic meningitis, step (5) bath temperature is 90-100 DEG C (preferred, bath temperature is 93-97 DEG C, and more preferably, bath temperature is 95 DEG C).
The injection liquid of described treatment epidemic meningitis, step (5) adjust ph to 6.5-7.5 (preferred, adjust ph to 6.8-7.2, more preferably, adjust ph to 7.0).
The pharmacology of the present invention's main Chinese medicine material used is as follows:
Japanese Honeysuckle: nature and flavor: sweet; Cold. Gui Jing: lung; Stomach warp. Effect: clearing heat and detoxicating. Cure mainly: warm disease is generated heat; Toxic-heat and blood stasis; Carbuncle swells furunculosis; Larynx numbness and multiple infectious diseases.
Rhizome of cyrtomium: base is former: be Dryopteridaceae plant dryopteris crassirhizoma, female dragon section plant moth eyebrows fern, Qiu Zi fern section plant pod fern, Osmundaceae plant osmund, the rhizome of blechnoid section plant blechnoid, sago cycas fern, chain fern etc. Nature and flavor: bitter, cool. Gui Jing: enter liver, stomach warp. Function cures mainly: kill ascarid, silk ribbon, pinworm, heat-clearing, removing toxic substances, cool blood, hemostasis. Control common cold due to wind-heat. Warm macula, spits blood, bleeding from five sense organs or subcutaneous tissue, discharging fresh blood stool, bloody flux, metrorrhagia, and under band, sore, hematuria, menorrhagia, knife wound is hemorrhage, roundworm, rich worm, teniasis, artificial abortion, postpartum hemorrhage.
The capsule of weeping forsythia: base is former: be the fruit of the Oleaceae plants capsule of weeping forsythia. Nature and flavor: bitter, micro-cold. Gui Jing: return lung, the heart, small intestine warp. Function cures mainly: clearing heat and detoxicating, dispersing swelling and dissipating binds, dispelling wind and heat pathogens. For ulcer, scrofula, acute mastitis, erysipelas, common cold due to wind-heat, warm disease is sought from the beginning of, warm people, high hot polydipsia, and coma sends out spot, and heat drenches puckery pain.
Wall money: base is former: Bi Qian section animal wall money worm. Nature and flavor: hardship salty, micro-, cool in nature. Gui Jing: lung, liver, large intestine channel. Function cures mainly: clearing heat and detoxicating, hemostasis. For pharyngolaryngitis, tonsillitis, oral cavity, gum ulcer, nosebleed epistaxis and metal-inflicted wound are hemorrhage.
Herba galinsogae parviflorae: base is former: be the full grass of feverfew Herba galinsogae parviflorae. Nature and flavor: light are flat. Function cures mainly: hemostasis, anti-inflammatory. Cure mainly tonsillitis, pharyngolaryngitis, acute icterohepatitis; Wound hemorrhage is controlled in external application.
The injection liquid scientific formula for the treatment of epidemic meningitis provided by the invention, preparation is simple, and products obtained therefrom is safe and reliable. In addition, the excellent results of the present invention also shows:
1, from causing, the cause of disease of epidemic meningitis carries out analytic demonstration in the present invention, and in conjunction with illness, development is filled a prescription;
2, this prescription is taking clearing heat and detoxicating, anti-inflammatory analgetic as primary efficacy;
3, the present invention is evident in efficacy, and clinical trial proves, products obtained therefrom has efficiency can reach 93.3%.
Embodiment
The technical scheme of the present invention is described in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
Embodiment 1The injection liquid for the treatment of epidemic meningitis, is prepared from (getting 20g for every part) primarily of following bulk drugs: Japanese Honeysuckle 1.2 parts, rhizome of cyrtomium 0.4 part, the capsule of weeping forsythia 0.5 part, wall money 0.4 part, Herba galinsogae parviflorae 0.3 part.
The preparation method of the injection liquid of above-mentioned treatment epidemic meningitis is:
(1) by Japanese Honeysuckle and capsule of weeping forsythia decon, pulverizing, be placed in wet distillation device, add water distillation and extraction three times, (add water into medicinal material weight 5 times for the first time, and second time is 4 times, and third time is 3 times), collects distillate;
(2) slightly being soaked by rhizome of cyrtomium clear water, section, the weight ratio being then placed in pot, rice and medicinal material together with rice is 1:2, constantly turns over stir-fry medicinal material, and it is deep yellow that slow fire is fried to rice, and rhizome of cyrtomium is smoked to yellow, goes out pot, and sieve removes rice, dries in the air cool;
(3) get wall money decon, it is placed in appropriate vessel, dries with slow fire, take out, cool;
(4) medicinal material obtained by step (2) (3) being placed in marmite together with Herba galinsogae parviflorae, add the warm water immersion 40 minutes of medicinal material weight 5 times, then big fire is boiled, turn little fire to decoct 30 minutes, filter, collect filtrate, remaining filter residue is watered, decoct and boil 40 minutes, filter, collect filtrate, again filter residue is watered for two times, decoct and boil 30 minutes, filter, merge three filtrates;
(5) step (4) gained filtrate decompression is concentrated 1/2nd to original volume, three times are processed with alcohol settling, in solution, alcohol content is 70% for the first time, second time is 80%, third time 85%, all place 12h every time, filter, filtrate decompression concentrates to without alcohol taste, inject the gac with water and 0.5%, water-bath 90 DEG C, heat 30 minutes, cool, refrigeration 24h, filter, add step (1) gained distillate, stir even, by 5% sodium hydroxide solution adjust ph to 6.5, finally add the phenylcarbinol of liquor capacity 0.1%, filter, embedding, high pressure steam sterilization, obtain injection liquid.
Embodiment 2The injection liquid for the treatment of epidemic meningitis, is prepared from (getting 10g for every part) primarily of following bulk drugs: Japanese Honeysuckle 2.0 parts, rhizome of cyrtomium 1.6 parts, the capsule of weeping forsythia 1.2 parts, wall money 1.0 parts, Herba galinsogae parviflorae 0.6 part.
The preparation method of the injection liquid for the treatment of epidemic meningitis is:
(1) by Japanese Honeysuckle and capsule of weeping forsythia decon, pulverizing, be placed in wet distillation device, add water distillation and extraction three times, (add water into medicinal material weight 5 times for the first time, and second time is 4 times, and third time is 3 times), collects distillate;
(2) slightly being soaked by rhizome of cyrtomium clear water, section, the weight ratio being then placed in pot, rice and medicinal material together with rice is 1:2, constantly turns over stir-fry medicinal material, and it is deep yellow that slow fire is fried to rice, and rhizome of cyrtomium is smoked to yellow, goes out pot, and sieve removes rice, dries in the air cool;
(3) get wall money decon, it is placed in appropriate vessel, dries with slow fire, take out, cool;
(4) medicinal material obtained by step (2) (3) being placed in marmite together with Herba galinsogae parviflorae, add the warm water immersion 60 minutes of medicinal material weight 8 times, then big fire is boiled, turn little fire to decoct 70 minutes, filter, collect filtrate, remaining filter residue is watered, decoct and boil 40 minutes, filter, collect filtrate, again filter residue is watered for two times, decoct and boil 30 minutes, filter, merge three filtrates;
(5) step (4) gained filtrate decompression is concentrated 1/2nd to original volume, three times are processed with alcohol settling, in solution, alcohol content is 70% for the first time, second time is 80%, third time 85%, all place 12h every time, filter, filtrate decompression concentrates to without alcohol taste, inject the gac with water and 0.5%, water-bath 100 DEG C, heat 30 minutes, cool, refrigeration 24h, filter, add step (1) gained distillate, stir even, by 5% sodium hydroxide solution adjust ph to 7.5, finally add the phenylcarbinol of liquor capacity 0.1%, filter, embedding, high pressure steam sterilization, obtain injection liquid.
Model case: xxx, man, 64 years old. This morning starts heating without obvious inducement, headache, and rear vomiting is in injection, and companion slightly shivers with cold, sore all over. Patient has coronary heart disease medical history, dare not arbitrarily medication, then arrive examination in hospital, time medical, body temperature 39.5 DEG C, body temperature raises without evident regularity, and mind is clear, and luminous reflectance is responsive, slight pharyngalgia, cough, health other have no malaise symptoms, make a definite diagnosis after further examination as epidemic meningitis.
The injection liquid of injection the present embodiment gained treatment epidemic meningitis, each 3-5ml, every day 1 time, 7 days courses for the treatment of. Injecting after two days, body temperature is down to normal range, and katzeniammer slows down, and vomiting stops, and continues injection after 5 days, and the every reaction of patient is all good, and without malaise symptoms, consolidate curative effect continues to have injected again 3 days, and clinical symptom completely dissolve, did not recur in half a year.
Embodiment 3The injection liquid for the treatment of epidemic meningitis, is prepared from (getting 30g for every part) primarily of following bulk drugs: Japanese Honeysuckle 1.4 parts, rhizome of cyrtomium 0.8 part, the capsule of weeping forsythia 0.7 part, wall money 0.6 part, Herba galinsogae parviflorae 0.4 part.
The preparation method of the injection liquid for the treatment of epidemic meningitis is:
(1) by Japanese Honeysuckle and capsule of weeping forsythia decon, pulverizing, be placed in wet distillation device, add water distillation and extraction three times, (add water into medicinal material weight 5 times for the first time, and second time is 4 times, and third time is 3 times), collects distillate;
(2) slightly being soaked by rhizome of cyrtomium clear water, section, the weight ratio being then placed in pot, rice and medicinal material together with rice is 1:2, constantly turns over stir-fry medicinal material, and it is deep yellow that slow fire is fried to rice, and rhizome of cyrtomium is smoked to yellow, goes out pot, and sieve removes rice, dries in the air cool;
(3) get wall money decon, it is placed in appropriate vessel, dries with slow fire, take out, cool;
(4) medicinal material obtained by step (2) (3) being placed in marmite together with Herba galinsogae parviflorae, add the warm water immersion 40 minutes of medicinal material weight 6 times, then big fire is boiled, turn little fire to decoct 30 minutes, filter, collect filtrate, remaining filter residue is watered, decoct and boil 40 minutes, filter, collect filtrate, again filter residue is watered for two times, decoct and boil 30 minutes, filter, merge three filtrates;
(5) step (4) gained filtrate decompression is concentrated 1/2nd to original volume, three times are processed with alcohol settling, in solution, alcohol content is 70% for the first time, second time is 80%, third time 85%, all place 12h every time, filter, filtrate decompression concentrates to without alcohol taste, inject the gac with water and 0.5%, water-bath 93 DEG C, heat 30 minutes, cool, refrigeration 24h, filter, add step (1) gained distillate, stir even, by 5% sodium hydroxide solution adjust ph to 6.8, finally add the phenylcarbinol of liquor capacity 0.1%, filter, embedding, high pressure steam sterilization, obtain injection liquid.
Model case: xxx, man, 3 years old. Before two days, infant starts without obvious inducement to occur crying and screaming afternoon, father and mother find that its high heat is with shiver with cold, after start vomiting, then go to see a doctor, body temperature 39.9 DEG C time medical, infant expression is dull, lower limb are mucocutaneous dark or red-purple petechia ecchymosis, making a definite diagnosis as coventional type epidemic meningitis through hospital diagnosis inspection, hospital adopts western medical treatment, within 3 days, has no improvement.
Recommend to adopt the injection liquid of the present embodiment gained treatment epidemic meningitis by people, adopt once a day, each 3-5ml, 7 days courses for the treatment of. Injecting after 3 days, infant body temperature is normal, and spirit is improved, and stops vomiting, continues injection 5 days, and all malaise symptoms all disappear, and petechia ecchymosis becomes light and not easily just sees, continuing to strengthen treatment 4 days, infant clinical symptom completely dissolve, does not recur so far.
Embodiment 4The injection liquid for the treatment of epidemic meningitis, is prepared from (getting 30g for every part) primarily of following bulk drugs: Japanese Honeysuckle 1.8 parts, rhizome of cyrtomium 1.2 parts, the capsule of weeping forsythia 1.0 parts, wall money 0.8 part, Herba galinsogae parviflorae 0.5 part.
The preparation method of the injection liquid for the treatment of epidemic meningitis is:
(1) by Japanese Honeysuckle and capsule of weeping forsythia decon, pulverizing, be placed in wet distillation device, add water distillation and extraction three times, (add water into medicinal material weight 5 times for the first time, and second time is 4 times, and third time is 3 times), collects distillate;
(2) slightly being soaked by rhizome of cyrtomium clear water, section, the weight ratio being then placed in pot, rice and medicinal material together with rice is 1:2, constantly turns over stir-fry medicinal material, and it is deep yellow that slow fire is fried to rice, and rhizome of cyrtomium is smoked to yellow, goes out pot, and sieve removes rice, dries in the air cool;
(3) get wall money decon, it is placed in appropriate vessel, dries with slow fire, take out, cool;
(4) medicinal material obtained by step (2) (3) being placed in marmite together with Herba galinsogae parviflorae, add the warm water immersion 60 minutes of medicinal material weight 7 times, then big fire is boiled, turn little fire to decoct 70 minutes, filter, collect filtrate, remaining filter residue is watered, decoct and boil 40 minutes, filter, collect filtrate, again filter residue is watered for two times, decoct and boil 30 minutes, filter, merge three filtrates;
(5) step (4) gained filtrate decompression is concentrated 1/2nd to original volume, three times are processed with alcohol settling, in solution, alcohol content is 70% for the first time, second time is 80%, third time 85%, all place 12h every time, filter, filtrate decompression concentrates to without alcohol taste, inject the gac with water and 0.5%, water-bath 97 DEG C, heat 30 minutes, cool, refrigeration 24h, filter, add step (1) gained distillate, stir even, by 5% sodium hydroxide solution adjust ph to 7.2, finally add the phenylcarbinol of liquor capacity 0.1%, filter, embedding, high pressure steam sterilization, obtain injection liquid.
Embodiment 5The injection liquid for the treatment of epidemic meningitis, is prepared from (getting 20g for every part) primarily of following bulk drugs: Japanese Honeysuckle 1.6 parts, rhizome of cyrtomium 1.0 parts, the capsule of weeping forsythia 0.85 part, wall money 0.7 part, Herba galinsogae parviflorae 0.45 part.
The preparation method of the injection liquid for the treatment of epidemic meningitis is:
(1) by Japanese Honeysuckle and capsule of weeping forsythia decon, pulverizing, be placed in wet distillation device, add water distillation and extraction three times, (add water into medicinal material weight 5 times for the first time, and second time is 4 times, and third time is 3 times), collects distillate;
(2) slightly being soaked by rhizome of cyrtomium clear water, section, the weight ratio being then placed in pot, rice and medicinal material together with rice is 1:2, constantly turns over stir-fry medicinal material, and it is deep yellow that slow fire is fried to rice, and rhizome of cyrtomium is smoked to yellow, goes out pot, and sieve removes rice, dries in the air cool;
(3) get wall money decon, it is placed in appropriate vessel, dries with slow fire, take out, cool;
(4) medicinal material obtained by step (2) (3) being placed in marmite together with Herba galinsogae parviflorae, add the warm water immersion 50 minutes of medicinal material weight 6.5 times, then big fire is boiled, turn little fire to decoct 50 minutes, filter, collect filtrate, remaining filter residue is watered, decoct and boil 40 minutes, filter, collect filtrate, again filter residue is watered for two times, decoct and boil 30 minutes, filter, merge three filtrates;
(5) step (4) gained filtrate decompression is concentrated 1/2nd to original volume, three times are processed with alcohol settling, in solution, alcohol content is 70% for the first time, second time is 80%, third time 85%, all place 12h every time, filter, filtrate decompression concentrates to without alcohol taste, inject the gac with water and 0.5%, water-bath 95 DEG C, heat 30 minutes, cool, refrigeration 24h, filter, add step (1) gained distillate, stir even, by 5% sodium hydroxide solution adjust ph to 7.0, finally add the phenylcarbinol of liquor capacity 0.1%, filter, embedding, high pressure steam sterilization, obtain injection liquid.
Test example 1The clinical application of the injection liquid of embodiment 5 gained treatment meningococcal meningitis: in December ,-2013 in February, 2012,264 routine common meningococcal meningitis outpatient service patients are screened in 4 hospitals, wherein women 128 example, the male sex 136 example, the oldest 21 years old, minimal ages 1 years old, 10.7 years old mean age. Case definition: how (1) falls ill at spring and summer and early autumn, often has virus infection history. (2) there is heating, headache, vomiting, diarrhoea, the disturbance of consciousness, even the symptoms such as convulsions stupor. Before infant, fontanel is full. (3) positive is levied in meninx stimulation, sometimes can draw pathology reflection. (4) cerebrospinal fluid outward appearance is limpid or micro-muddy, and pressure slightly increases, and cell count is mostly between 10��500/mm3, and lymphocyte occupies the majority. Albumen slightly increases, and sugar and muriate are normal. Minority case cerebrospinal fluid is without obvious change. The person of having ready conditions can do virus purification and Serological testing. (5) electroencephalogram: diffusivity slow wave often occurs.
Patient is divided at random two groups, experimental group 164 example and control group 100 example, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability. Experimental group takes embodiment 5 products obtained therefrom, and every day injects once, intramuscular injection, and each 3-5m1(adjusts to some extent depending on particular case), 7 days courses for the treatment of, control group injects other medicine (the conventional medicine such as Sulphadiazine Sodium, penicillin G, penbritin). Between medication period, two groups of patients are observed continuously, record symptom and change.
Curative effect situation criterion: cure: clinical symptom all disappears, health physical and chemical index inspection is normal, observes and within three months, has no repeatedly; Effective: clinical symptom relief, the state of an illness is controlled, health physical and chemical index inspection improvement or normal; Invalid: clinical symptom is without obviously taking a turn for the better or increases the weight of.
Treatment result: the experimental group patient of the injection liquid of injection embodiment 5 gained treatment epidemic meningitis, cure 102(62.2%), effective 51(31.1%), invalid 11(6.7%), the efficiency that always has of experimental group is 93.3%, the healing of control group and effective number of cases are respectively 54 examples and 33 examples, always have efficiency to be 87%. Experimental group is relatively better than control group result for the treatment of, and during treatment, untoward reaction does not occur in experimental group patient, and control group has small number of patients that medicament occurs slight untoward reaction, it is seen that the relatively conventional Western medicine of experimental group injection liquid is safer.
In the present invention, Japanese Honeysuckle and rhizome of cyrtomium have clearing heat and detoxicating, cooling blood for hemostasis effect; The capsule of weeping forsythia has dispersing swelling and dissipating binds, dispelling wind and heat pathogens effect; Wall money has clearing heat and detoxicating, anastalsis; Herba galinsogae parviflorae has hemostasis and anti-inflammation effect, and several Chinese medicine material acting in conjunction, plays clearing heat and detoxicating altogether, anti-inflammatory analgetic effect, pathogenic bacteria in purged body, strengthens body immunity.
It should be appreciated that the embodiment more representational example that is the present invention, it is clear that the technical scheme of the present invention is not limited to above-described embodiment, it is also possible to have a lot of distortion. The those of ordinary skill of this area, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (7)

1. treat the injection liquid of epidemic meningitis, it is characterised in that, it is prepared from primarily of following bulk drugs, it is weight part: Japanese Honeysuckle 1.4, rhizome of cyrtomium 0.8, the capsule of weeping forsythia 0.7, wall money 0.6, Herba galinsogae parviflorae 0.4.
2. the preparation method of the injection liquid for the treatment of epidemic meningitis as claimed in claim 1, it is characterised in that, step is:
(1) by Japanese Honeysuckle and capsule of weeping forsythia decon, pulverize, it is placed in wet distillation device, adds water distillation and extraction three times, collect distillate;
(2) slightly being soaked by rhizome of cyrtomium clear water, section, is then placed in pot together with rice, constantly turns over stir-fry medicinal material, and it is deep yellow that slow fire is fried to rice, and rhizome of cyrtomium is smoked to yellow, goes out pot, and sieve removes rice, dries in the air cool;
(3) get wall money decon, it is placed in appropriate vessel, dries with slow fire, take out, cool;
(4) medicinal material obtained by step (2) (3) is placed in marmite together with Herba galinsogae parviflorae, warm water dipping 40-60 minute (preferred, warm water immersion 50 minutes), then big fire is boiled, and turns little fire and decocts 30-70 minute (preferred, to turn little fire and decoct 50 minutes), filter, collect filtrate, remaining filter residue is watered, decoct and boil 40 minutes, filter, collect filtrate, again filter residue is watered for two times, decoct and boil 30 minutes, filter, merge three filtrates;
(5) step (4) gained filtrate decompression is concentrated 1/2nd to original volume, three times are processed with alcohol settling, in solution, alcohol content is 70% for the first time, second time is 80%, third time 85%, all place 12h every time, filter, filtrate decompression concentrates to without alcohol taste, inject the gac with water and 0.5%, heating in water bath stirs 30 minutes, cool, refrigeration 24h, filter, add step (1) gained distillate, stir even, by 5% sodium hydroxide solution adjust ph, finally add the phenylcarbinol of liquor capacity 0.1%, filter, embedding, high pressure steam sterilization, obtain injection liquid.
3. the injection liquid for the treatment of epidemic meningitis as claimed in claim 2, it is characterised in that, step (1) adds water and distills 5 times into medicinal material weight that add water for the first time, and second time is 4 times, and third time is 3 times.
4. the injection liquid for the treatment of epidemic meningitis as claimed in claim 2, it is characterised in that, the weight ratio of step (2) rice and medicinal material is 1:2.
5. the injection liquid for the treatment of epidemic meningitis as claimed in claim 2, it is characterised in that, step (4) heat the water yield be medicinal material weight 5-8 doubly (preferred, the water yield of heating be medicinal material weight 6-7 doubly, more preferably, the water yield of heating is 6.5 times of medicinal material weight).
6. the injection liquid for the treatment of epidemic meningitis as claimed in claim 2, it is characterised in that, step (5) bath temperature is 90-100 DEG C (preferred, bath temperature is 93-97 DEG C, and more preferably, bath temperature is 95 DEG C).
7. the injection liquid for the treatment of epidemic meningitis as claimed in claim 2, it is characterised in that, step (5) adjust ph to 6.5-7.5 (preferred, adjust ph to 6.8-7.2, more preferably, adjust ph to 7.0).
CN201610159135.1A 2014-11-18 2014-11-18 Injection for treating epidemic cerebrospinal meningitis Withdrawn CN105616518A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410653623.9A CN104352571B (en) 2014-11-18 2014-11-18 The injection for the treatment of epidemic encephalitis and preparation method

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201410653623.9A Division CN104352571B (en) 2014-11-18 2014-11-18 The injection for the treatment of epidemic encephalitis and preparation method

Publications (1)

Publication Number Publication Date
CN105616518A true CN105616518A (en) 2016-06-01

Family

ID=52519944

Family Applications (5)

Application Number Title Priority Date Filing Date
CN201610159133.2A Withdrawn CN105687333A (en) 2014-11-18 2014-11-18 Injection for treating epidemic cerebrospinal meningitis
CN201410653623.9A Active CN104352571B (en) 2014-11-18 2014-11-18 The injection for the treatment of epidemic encephalitis and preparation method
CN201610159132.8A Withdrawn CN105687332A (en) 2014-11-18 2014-11-18 Injection for treating epidemic cerebrospinal meningitis
CN201610159136.6A Withdrawn CN105687334A (en) 2014-11-18 2014-11-18 Injection capable of treating epidemic cerebrospinal meningitis and preparation method thereof
CN201610159135.1A Withdrawn CN105616518A (en) 2014-11-18 2014-11-18 Injection for treating epidemic cerebrospinal meningitis

Family Applications Before (4)

Application Number Title Priority Date Filing Date
CN201610159133.2A Withdrawn CN105687333A (en) 2014-11-18 2014-11-18 Injection for treating epidemic cerebrospinal meningitis
CN201410653623.9A Active CN104352571B (en) 2014-11-18 2014-11-18 The injection for the treatment of epidemic encephalitis and preparation method
CN201610159132.8A Withdrawn CN105687332A (en) 2014-11-18 2014-11-18 Injection for treating epidemic cerebrospinal meningitis
CN201610159136.6A Withdrawn CN105687334A (en) 2014-11-18 2014-11-18 Injection capable of treating epidemic cerebrospinal meningitis and preparation method thereof

Country Status (1)

Country Link
CN (5) CN105687333A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103830523A (en) * 2014-03-07 2014-06-04 王玉芳 Traditional Chinese medicine composition for treating epidemic cerebrospinal meningitis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102119994B (en) * 2010-01-12 2012-05-23 冯陆冰 Traditional Chinese medicine enema for treating exogenous fever of infants
CN104523863B (en) * 2014-12-03 2019-03-01 中国农业科学院兰州畜牧与兽药研究所 A kind of traditional Chinese medicine infusion solution and its preparation method and application

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103830523A (en) * 2014-03-07 2014-06-04 王玉芳 Traditional Chinese medicine composition for treating epidemic cerebrospinal meningitis

Also Published As

Publication number Publication date
CN104352571A (en) 2015-02-18
CN105687332A (en) 2016-06-22
CN105687334A (en) 2016-06-22
CN104352571B (en) 2016-08-10
CN105687333A (en) 2016-06-22

Similar Documents

Publication Publication Date Title
CN102139030B (en) Oral Chinese herbal preparation for treating gingivitis and preparation method thereof
CN102579824B (en) Method for preparing traditional Chinese medicine lotion for treating ecthyma caused by addiction to chillies
CN103798472B (en) A kind of health protection tea and health care's preparation
CN105056078A (en) Traditional Chinese medicine composition for treating stomach fire exuberance, toothache and ozostomia
CN104666689A (en) Medicine for treating hypertension
CN105616518A (en) Injection for treating epidemic cerebrospinal meningitis
CN102451249B (en) Drug for treating burn and scald, and application thereof
CN105106651A (en) Traditional Chinese medicine for treating clear qi failing to ascend type nerve deafness
CN105521026A (en) Injection for treating epidemic cerebrospinal meningitis
CN105521335A (en) Traditional Chinese medicine for treating paroxysmal supraventricular tachycardia and preparation method of traditional Chinese medicine
CN104825887A (en) Medicament composition for preventing and treating bovine foot and mouth disease and preparation method of medicament composition
CN105535819A (en) Traditional Chinese medicine for cleaning blood and enhancing body immunity
CN104906416B (en) A kind of Chinese medicine composition for treating type of hyperactivity of fire caused by deficiency of YIN purpura
CN105616559A (en) Composition for treating acute bacillary dysentery
CN104524305A (en) Mouth wash relieving toothache and preparation method thereof
CN102614362A (en) Preparation method for traditional Chinese medicine lotion for treating smoking type ecthyma
CN107243047A (en) It is a kind of to treat the Chinese medicine composition that caused swelling and aching of gum and carious tooth pain are contained in fiery poison
CN105943794A (en) Traditional Chinese medicine for treating insomnia by combining acupuncture and moxibustion and preparation method thereof
CN106727820A (en) Prevent and treat the pharmaceutical composition of optic atrophy
CN106727940A (en) A kind of health protection tea with treatment headache due to pathogenic wind-heat effect and preparation method thereof
CN106511865A (en) Pharmaceutical for treating halitosis and preparation method thereof
CN105770523A (en) Medicinal composition for treating optic atrophy
CN106692235A (en) Pharmaceutical composition for preventing and treating keratitis
CN105582173A (en) Traditional Chinese medicine preparation for treating epistaxis and preparation method
CN105288331A (en) Traditional Chinese medicine composition for treating hordeolum

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information
CB02 Change of applicant information

Address after: Beijing District of Gansu province Ludongming 730900 Baiyin District No. 4 1-502

Applicant after: Hao Jianyou

Address before: Huaiyin District of Ji'nan City, Shandong province 250000 Ji Qi Road No. 112

Applicant before: Hao Jianyou

WW01 Invention patent application withdrawn after publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20160601